Antibody data
- Antibody Data
- Antigen structure
- References [1]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 50-9745-42 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- S100A8 Monoclonal Antibody (CF-145), eFluor™ 660, eBioscience™
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- Description: The monoclonal antibody CF-145 recognizes human S100A8. S100A8, also known as migration inhibitory factor-related protein 8 (MRP-8) or Calgranulin-A, is a calcium binding protein and member of the S100 family of proteins. S100A8 is expressed by neutrophils, monocytes, macrophages, granulocytes, and epithelial cells during dermatoses, such as psoriasis. S100A8 forms a heterodimer with S100A9, which together is known as calprotectin. S100A8 has antimicrobial and pro-apoptotic properties and is a pro-inflammatory mediator in acute and chronic inflammation. Levels of S100A8 are elevated in patients with various inflammatory disorders such as cystic fibrosis, rheumatoid arthritis, and chronic bronchitis. Upregulation of S100A8 is also observed in many tumors, including skin, breast, colon, pancreatic, and ovarian cancers.
- Antibody clone number
- CF-145
- Concentration
- 5 µL/Test
Submitted references FcγRIIB potentiates differentiation of myeloid-derived suppressor cells to mediate tumor immunoescape.
Wu L, Xu Y, Zhao H, Zhou Y, Chen Y, Yang S, Lei J, Zhang J, Wang J, Wu Y, Li Y
Theranostics 2022;12(2):842-858
Theranostics 2022;12(2):842-858
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Supportive validation
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- Invitrogen Antibodies (provider)
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- Experimental details
- Normal human peripheral blood cells were incubated with Human Fc Receptor Binding Inhibitor Purified (Product # 14-9161-73) for 20 minutes, then stained with Anti-Human CD11b PE (Product # 12-0118-42) followed by fixation and permeabilization with the Intracellular Fixation and Permeabilization Buffer Set (Product # 88-8824-00) and protocol. The cells were then stained with Mouse IgG2b K Isotype Control eFluor® 660 (Product # 50-4732-82) (left) or Anti-Human S100A8 eFluor® 660 (right). Cells in the monocyte gate were used for analysis.