DISP1

The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A novel segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched and, based on sequence identity to its mouse counterpart, the encoded protein may play an essential role in Hh patterning activities in the early embryo. [provided by RefSeq, Jul 2008]

Description

Dispatched RND transporter family member 1

Tissue specificity

Low tissue specificity

Subcell location

Nuclear bodies

Predicted location

Intracellular, Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (222815022 - 223005995)

Ensembl ID

ENSG00000154309  (ver. 103.38)

Orthologs

Mouse Disp1: ENSMUSG00000030768

UniProt

Q96F81

neXtProt

NX_Q96F81

Human splice variants
Mouse splice variants

Protein structure