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- Antibody Data
- Antigen structure
- References [21]
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- Product number
- V3257 - Provider product page
- Provider
- NSJ Bioreagents
- Product name
- Desmoglein 3 Antibody / DSG3
- Antibody type
- Monoclonal
- Description
- Purified
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Antibody clone number
- 5H10
- Vial size
- 20 µg, 100 µg (with BSA, sodium azide), 100 µg (without BSA, sodium azide), 7 ml (prediluted for IHC)
- Concentration
- 0.2 mg/ml
- Storage
- Store the Desmoglein 3 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Submitted references Desmoglein 3 regulates membrane trafficking of cadherins, an implication in cell-cell adhesion.
Nuclear magnetic resonance titration of the interaction between pemphigus vulgaris autoantibodies and REWVKFAKPCRE, a therapeutic desmoglein 3 peptide.
Evidence for Dsg3 in regulating Src signaling by competing with it for binding to caveolin-1.
Pemphigus vulgaris autoimmune globulin induces Src-dependent tyrosine-phosphorylation of plakophilin 3 and its detachment from desmoglein 3.
DSG3 facilitates cancer cell growth and invasion through the DSG3-plakoglobin-TCF/LEF-Myc/cyclin D1/MMP signaling pathway.
Desmoglein 3 acting as an upstream regulator of Rho GTPases, Rac-1/Cdc42 in the regulation of actin organisation and dynamics.
Homology, similarity, and identity in peptide epitope immunodefinition.
Cardiac tissue-restricted deletion of plakoglobin results in progressive cardiomyopathy and activation of {beta}-catenin signaling.
Desmosome dynamics in migrating epithelial cells requires the actin cytoskeleton.
Novel multicellular organotypic models of normal and malignant breast: tools for dissecting the role of the microenvironment in breast cancer progression.
Apoptolysis: a novel mechanism of skin blistering in pemphigus vulgaris linking the apoptotic pathways to basal cell shrinkage and suprabasal acantholysis.
Cleavage of desmoglein 3 can explain its depletion from keratinocytes in pemphigus vulgaris.
Deregulation of keratinocyte differentiation and activation: a hallmark of venous ulcers.
IgG autoantibodies directed against desmoglein 3 cause dissociation of keratinocytes in canine pemphigus vulgaris and paraneoplastic pemphigus.
Non-redundant peptidomes from DAPs: towards "the vaccine"?
Defining Peptide Sequences: From Antigenicity to Immunogenicity Through Redundancy
Proteomic analysis in human breast cancer: identification of a characteristic protein expression profile of malignant breast epithelium.
Delineation of diversified desmoglein distribution in stratified squamous epithelia: implications in diseases.
The N-terminal fraction of desmoglein 3 encompassing its immunodominant domain is present in human serum: implications for pemphigus vulgaris autoimmunity.
Characterization of polyclonal antibodies raised against a linear peptide determinant of desmoglein-3.
Fate of desmosomal proteins in apoptotic epidermal cells.
Moftah H, Dias K, Apu EH, Liu L, Uttagomol J, Bergmeier L, Kermorgant S, Wan H
Cell adhesion & migration 2016 Jun 2;:1-22
Cell adhesion & migration 2016 Jun 2;:1-22
Nuclear magnetic resonance titration of the interaction between pemphigus vulgaris autoantibodies and REWVKFAKPCRE, a therapeutic desmoglein 3 peptide.
Lucchese A, Sinha AA
Clinical and experimental dermatology 2016 Aug;41(6):585-90
Clinical and experimental dermatology 2016 Aug;41(6):585-90
Evidence for Dsg3 in regulating Src signaling by competing with it for binding to caveolin-1.
Wan H, Lin K, Tsang SM, Uttagomol J
Data in brief 2015 Dec 3;6:124-34
Data in brief 2015 Dec 3;6:124-34
Pemphigus vulgaris autoimmune globulin induces Src-dependent tyrosine-phosphorylation of plakophilin 3 and its detachment from desmoglein 3.
Cirillo N, AlShwaimi E, McCullough M, Prime SS
Autoimmunity 2014 Mar;47(2):134-40
Autoimmunity 2014 Mar;47(2):134-40
DSG3 facilitates cancer cell growth and invasion through the DSG3-plakoglobin-TCF/LEF-Myc/cyclin D1/MMP signaling pathway.
Chen YJ, Lee LY, Chao YK, Chang JT, Lu YC, Li HF, Chiu CC, Li YC, Li YL, Chiou JF, Cheng AJ
PloS one 2013;8(5):e64088
PloS one 2013;8(5):e64088
Desmoglein 3 acting as an upstream regulator of Rho GTPases, Rac-1/Cdc42 in the regulation of actin organisation and dynamics.
Tsang SM, Brown L, Gadmor H, Gammon L, Fortune F, Wheeler A, Wan H
Experimental cell research 2012 Nov 1;318(18):2269-83
Experimental cell research 2012 Nov 1;318(18):2269-83
Homology, similarity, and identity in peptide epitope immunodefinition.
Kanduc D
Journal of peptide science : an official publication of the European Peptide Society 2012 Aug;18(8):487-94
Journal of peptide science : an official publication of the European Peptide Society 2012 Aug;18(8):487-94
Cardiac tissue-restricted deletion of plakoglobin results in progressive cardiomyopathy and activation of {beta}-catenin signaling.
Li J, Swope D, Raess N, Cheng L, Muller EJ, Radice GL
Molecular and cellular biology 2011 Mar;31(6):1134-44
Molecular and cellular biology 2011 Mar;31(6):1134-44
Desmosome dynamics in migrating epithelial cells requires the actin cytoskeleton.
Roberts BJ, Pashaj A, Johnson KR, Wahl JK 3rd
Experimental cell research 2011 Dec 10;317(20):2814-22
Experimental cell research 2011 Dec 10;317(20):2814-22
Novel multicellular organotypic models of normal and malignant breast: tools for dissecting the role of the microenvironment in breast cancer progression.
Holliday DL, Brouilette KT, Markert A, Gordon LA, Jones JL
Breast cancer research : BCR 2009;11(1):R3
Breast cancer research : BCR 2009;11(1):R3
Apoptolysis: a novel mechanism of skin blistering in pemphigus vulgaris linking the apoptotic pathways to basal cell shrinkage and suprabasal acantholysis.
Grando SA, Bystryn JC, Chernyavsky AI, Frusić-Zlotkin M, Gniadecki R, Lotti R, Milner Y, Pittelkow MR, Pincelli C
Experimental dermatology 2009 Sep;18(9):764-70
Experimental dermatology 2009 Sep;18(9):764-70
Cleavage of desmoglein 3 can explain its depletion from keratinocytes in pemphigus vulgaris.
Cirillo N, Campisi G, Gombos F, Perillo L, Femiano F, Lanza A
Experimental dermatology 2008 Oct;17(10):858-63
Experimental dermatology 2008 Oct;17(10):858-63
Deregulation of keratinocyte differentiation and activation: a hallmark of venous ulcers.
Stojadinovic O, Pastar I, Vukelic S, Mahoney MG, Brennan D, Krzyzanowska A, Golinko M, Brem H, Tomic-Canic M
Journal of cellular and molecular medicine 2008 Dec;12(6B):2675-90
Journal of cellular and molecular medicine 2008 Dec;12(6B):2675-90
IgG autoantibodies directed against desmoglein 3 cause dissociation of keratinocytes in canine pemphigus vulgaris and paraneoplastic pemphigus.
Nishifuji K, Olivry T, Ishii K, Iwasaki T, Amagai M
Veterinary immunology and immunopathology 2007 Jun 15;117(3-4):209-21
Veterinary immunology and immunopathology 2007 Jun 15;117(3-4):209-21
Non-redundant peptidomes from DAPs: towards "the vaccine"?
Kanduc D, Lucchese A, Mittelman A
Autoimmunity reviews 2007 Apr;6(5):290-4
Autoimmunity reviews 2007 Apr;6(5):290-4
Defining Peptide Sequences: From Antigenicity to Immunogenicity Through Redundancy
Kanduc D
Current Pharmacogenomics 2006 March;4(1):33-37
Current Pharmacogenomics 2006 March;4(1):33-37
Proteomic analysis in human breast cancer: identification of a characteristic protein expression profile of malignant breast epithelium.
Hudelist G, Singer CF, Pischinger KI, Kaserer K, Manavi M, Kubista E, Czerwenka KF
Proteomics 2006 Mar;6(6):1989-2002
Proteomics 2006 Mar;6(6):1989-2002
Delineation of diversified desmoglein distribution in stratified squamous epithelia: implications in diseases.
Mahoney MG, Hu Y, Brennan D, Bazzi H, Christiano AM, Wahl JK 3rd
Experimental dermatology 2006 Feb;15(2):101-9
Experimental dermatology 2006 Feb;15(2):101-9
The N-terminal fraction of desmoglein 3 encompassing its immunodominant domain is present in human serum: implications for pemphigus vulgaris autoimmunity.
Lanza A, Femiano F, De Rosa A, Cammarota M, Lanza M, Cirillo N
International journal of immunopathology and pharmacology 2006 Apr-Jun;19(2):399-407
International journal of immunopathology and pharmacology 2006 Apr-Jun;19(2):399-407
Characterization of polyclonal antibodies raised against a linear peptide determinant of desmoglein-3.
Angelini G, Bonamonte D, Lin MS, Lucchese A, Mittelman A, Serpico R, Simone S, Sinha AA, Kanduc D
Journal of experimental therapeutics & oncology 2005;5(1):1-7
Journal of experimental therapeutics & oncology 2005;5(1):1-7
Fate of desmosomal proteins in apoptotic epidermal cells.
Weiske J, Huber O
Methods in molecular biology (Clifton, N.J.) 2005;289:175-92
Methods in molecular biology (Clifton, N.J.) 2005;289:175-92
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Supportive validation
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- NSJ Bioreagents (provider)
- Main image
- Experimental details
- SDS-PAGE Analysis of Purified, BSA-Free Desmoglein 3 Antibody (clone 5H10). Confirmation of Integrity and Purity of the Antibody.
