Antibody data

Product number
10-7539
Provider
ABEOMICS Inc.
Product name
Anti-Desmoglein 3 Antibody
Provider product page
ABEOMICS Inc. - 10-7539
Antibody type
Monoclonal
Description
DSG3 (Desmoglein 3) is a calcium-binding transmembrane glycoprotein component of desmosomes, conferring strong cell-cell adhesion. Desmosomes are button-like points of intercellular contact that allow the attachment of cytoskeletal elements to the plasma membrane at sites of cell-cell adhesion. DSG3 is expressed in basal and immediate suprabasal layers of skin. To maintain cell-cell adhesion DSG3 interacts with other desmosomal proteins, such as plakoglobin. Plakoglobin is closely related to Beta-catenin, which is a well-known downstream effector molecule in the canonical Wnt signaling pathway.DSG3 also promotes cancer cell growth and invasion through a plakoglobin-mediated signaling pathway.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antigen sequence
A partial length recombinant Desmog
lein 3 protein (amino acids 328-526
) was used as the immunogen for thi
s antibody.
Isotype
IgG
Antibody clone number
ABM4A31
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing
Provider Type Product Number
- No reagents -