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- Antibody Data
- Antigen structure
- References [16]
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- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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- Product number
- 18847-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#18847-1-AP, RRID:AB_10598163
- Product name
- IRF2BP2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated IRF2BP2 antibody (Cat. #18847-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Therapy resistance in AML is mediated by cytoplasmic sequestration of the transcriptional repressor IRF2BP2.
miR‑155 promotes an inflammatory response in HaCaT cells via the IRF2BP2/KLF2/NF‑κB pathway in psoriasis.
IRF2BP2 binds to a conserved RxSVI motif of protein partners and regulates megakaryocytic differentiation.
SPOP point mutations regulate substrate preference and affect its function.
Malate initiates a proton-sensing pathway essential for pH regulation of inflammation.
Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts.
IRF2BP2 is a novel HNF4α co-repressor: Its role in gluconeogenic gene regulation via biochemically labile interaction.
Identification of proximal SUMO-dependent interactors using SUMO-ID.
IRF2BP2 prevents ox-LDL-induced inflammation and EMT in endothelial cells via regulation of KLF2.
Transient deSUMOylation of IRF2BP proteins controls early transcription in EGFR signaling.
The Sumo proteome of proliferating and neuronal-differentiating cells reveals Utf1 among key Sumo targets involved in neurogenesis.
Dual genome-wide CRISPR knockout and CRISPR activation screens identify mechanisms that regulate the resistance to multiple ATR inhibitors.
The Tumor Suppressor Interferon Regulatory Factor 2 Binding Protein 2 Regulates Hippo Pathway in Liver Cancer by a Feedback Loop in Mice.
Hypoxia-induced Changes in SUMO Conjugation Affect Transcriptional Regulation Under Low Oxygen.
Down-regulation of interferon regulatory factor 2 binding protein 2 suppresses gastric cancer progression by negatively regulating connective tissue growth factor.
Control of Pathological Cardiac Hypertrophy by Transcriptional Corepressor IRF2BP2 (Interferon Regulatory Factor-2 Binding Protein 2).
Althoff MJ, Minhajuddin M, Stevens BM, Gillen AE, Gipson S, Patel SB, Shelton IT, Miller R, Vujovic A, Krug A, Young T, Showers WM, Dzieciatkowska M, Stephenson D, Tyagi A, Ellegast JM, Wright T, Stegmaier K, Opferman JT, D'Alessandro A, Smith CA, Jordan CT
bioRxiv : the preprint server for biology 2025 May 24;
bioRxiv : the preprint server for biology 2025 May 24;
miR‑155 promotes an inflammatory response in HaCaT cells via the IRF2BP2/KLF2/NF‑κB pathway in psoriasis.
Chen L, Liu C, Xiang X, Qiu W, Guo K
International journal of molecular medicine 2024 Nov;54(5)
International journal of molecular medicine 2024 Nov;54(5)
IRF2BP2 binds to a conserved RxSVI motif of protein partners and regulates megakaryocytic differentiation.
Wang G, Lu T, Zhang L, Ding J
Nature communications 2024 Nov 30;15(1):10425
Nature communications 2024 Nov 30;15(1):10425
SPOP point mutations regulate substrate preference and affect its function.
Deng Y, Ding W, Ma K, Zhan M, Sun L, Zhou Z, Lu L
Cell death & disease 2024 Feb 26;15(2):172
Cell death & disease 2024 Feb 26;15(2):172
Malate initiates a proton-sensing pathway essential for pH regulation of inflammation.
Chen YJ, Shi RC, Xiang YC, Fan L, Tang H, He G, Zhou M, Feng XZ, Tan JD, Huang P, Ye X, Zhao K, Fu WY, Li LL, Bian XT, Chen H, Wang F, Wang T, Zhang CK, Zhou BH, Chen W, Liang TT, Lv JT, Kang X, Shi YX, Kim E, Qin YH, Hettinghouse A, Wang KD, Zhao XL, Yang MY, Tang YZ, Piao HL, Guo L, Liu CJ, Miao HM, Tang KL
Signal transduction and targeted therapy 2024 Dec 30;9(1):367
Signal transduction and targeted therapy 2024 Dec 30;9(1):367
Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts.
Ellegast JM, Alexe G, Hamze A, Lin S, Uckelmann HJ, Rauch PJ, Pimkin M, Ross LS, Dharia NV, Robichaud AL, Conway AS, Khalid D, Perry JA, Wunderlich M, Benajiba L, Pikman Y, Nabet B, Gray NS, Orkin SH, Stegmaier K
Cancer discovery 2022 Jul 6;12(7):1760-1781
Cancer discovery 2022 Jul 6;12(7):1760-1781
IRF2BP2 is a novel HNF4α co-repressor: Its role in gluconeogenic gene regulation via biochemically labile interaction.
Kouketsu T, Monma R, Miyairi Y, Sawatsubashi S, Shima H, Igarashi K, Sugawara A, Yokoyama A
Biochemical and biophysical research communications 2022 Jul 30;615:81-87
Biochemical and biophysical research communications 2022 Jul 30;615:81-87
Identification of proximal SUMO-dependent interactors using SUMO-ID.
Barroso-Gomila O, Trulsson F, Muratore V, Canosa I, Merino-Cacho L, Cortazar AR, Pérez C, Azkargorta M, Iloro I, Carracedo A, Aransay AM, Elortza F, Mayor U, Vertegaal ACO, Barrio R, Sutherland JD
Nature communications 2021 Nov 18;12(1):6671
Nature communications 2021 Nov 18;12(1):6671
IRF2BP2 prevents ox-LDL-induced inflammation and EMT in endothelial cells via regulation of KLF2.
Jiang Y, Shen Q
Experimental and therapeutic medicine 2021 May;21(5):481
Experimental and therapeutic medicine 2021 May;21(5):481
Transient deSUMOylation of IRF2BP proteins controls early transcription in EGFR signaling.
Barysch SV, Stankovic-Valentin N, Miedema T, Karaca S, Doppel J, Nait Achour T, Vasudeva A, Wolf L, Sticht C, Urlaub H, Melchior F
EMBO reports 2021 Mar 3;22(3):e49651
EMBO reports 2021 Mar 3;22(3):e49651
The Sumo proteome of proliferating and neuronal-differentiating cells reveals Utf1 among key Sumo targets involved in neurogenesis.
Correa-Vázquez JF, Juárez-Vicente F, García-Gutiérrez P, Barysch SV, Melchior F, García-Domínguez M
Cell death & disease 2021 Mar 22;12(4):305
Cell death & disease 2021 Mar 22;12(4):305
Dual genome-wide CRISPR knockout and CRISPR activation screens identify mechanisms that regulate the resistance to multiple ATR inhibitors.
Schleicher EM, Dhoonmoon A, Jackson LM, Clements KE, Stump CL, Nicolae CM, Moldovan GL
PLoS genetics 2020 Nov;16(11):e1009176
PLoS genetics 2020 Nov;16(11):e1009176
The Tumor Suppressor Interferon Regulatory Factor 2 Binding Protein 2 Regulates Hippo Pathway in Liver Cancer by a Feedback Loop in Mice.
Feng X, Lu T, Li J, Yang R, Hu L, Ye Y, Mao F, He L, Xu J, Wang Z, Liu Y, Zhang Y, Ji H, Zhao Y, Cheng S, Tian W, Zhang L
Hepatology (Baltimore, Md.) 2020 Jun;71(6):1988-2004
Hepatology (Baltimore, Md.) 2020 Jun;71(6):1988-2004
Hypoxia-induced Changes in SUMO Conjugation Affect Transcriptional Regulation Under Low Oxygen.
Chachami G, Stankovic-Valentin N, Karagiota A, Basagianni A, Plessmann U, Urlaub H, Melchior F, Simos G
Molecular & cellular proteomics : MCP 2019 Jun;18(6):1197-1209
Molecular & cellular proteomics : MCP 2019 Jun;18(6):1197-1209
Down-regulation of interferon regulatory factor 2 binding protein 2 suppresses gastric cancer progression by negatively regulating connective tissue growth factor.
Yao Y, Wang Y, Li L, Xiang X, Li J, Chen J, Liu Z, Huang S, Xiong J, Deng J
Journal of cellular and molecular medicine 2019 Dec;23(12):8076-8089
Journal of cellular and molecular medicine 2019 Dec;23(12):8076-8089
Control of Pathological Cardiac Hypertrophy by Transcriptional Corepressor IRF2BP2 (Interferon Regulatory Factor-2 Binding Protein 2).
Fang J, Li T, Zhu X, Deng KQ, Ji YX, Fang C, Zhang XJ, Guo JH, Zhang P, Li H, Wei X
Hypertension (Dallas, Tex. : 1979) 2017 Sep;70(3):515-523
Hypertension (Dallas, Tex. : 1979) 2017 Sep;70(3):515-523
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 18847-1-AP(IRF2BP2 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-IRF2BP2 (IP:18847-1-AP, 3ug; Detection:18847-1-AP 1:500) with K-562 cells lysate 2400ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The IRF2BP2 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human IRF2BP2. This antibody recognizes human, mouse antigen. The IRF2BP2 antibody has been validated for the following applications: ELISA, WB, IHC, IP analysis.
