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- Antibody Data
- Antigen structure
- References [15]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 14944-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14944-1-AP, RRID:AB_2110990
- Product name
- GGPS1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated GGPS1 antibody (Cat. #14944-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Comprehensive analysis of a real-world cohort identifies geranylgeranyl diphosphate synthase 1 as a predictor of chemoresistance in small cell lung cancer.
ENKD1 modulates innate immune responses through enhanced geranylgeranyl pyrophosphate synthase activity.
Periodontal ligament fibroblasts utilize isoprenoid intermediate farnesyl diphosphate for maintaining osteo/cementogenic differentiation abilities.
Deficiency of geranylgeranyl biphosphate synthase in kidney tubules causes cystic kidney disease.
miR-612 Enhances RSL3-Induced Ferroptosis of Hepatocellular Carcinoma Cells via Mevalonate Pathway.
Quantitative proteomic profiling identifies global protein network dynamics in murine embryonic heart development.
Therapeutic targeting of the mevalonate-geranylgeranyl diphosphate pathway with statins overcomes chemotherapy resistance in small cell lung cancer.
Cysteine-Rich LIM-Only Protein 4 (CRP4) Promotes Atherogenesis in the ApoE(-/-) Mouse Model.
Geranylgeranyl diphosphate synthase 1 knockdown suppresses NLRP3 inflammasome activity via promoting autophagy in sepsis-induced acute lung injury.
Conditional loss of geranylgeranyl diphosphate synthase alleviates acute obstructive cholestatic liver injury by regulating hepatic bile acid metabolism.
Inhibition of GGPPS1 attenuated LPS-induced acute lung injury and was associated with NLRP3 inflammasome suppression.
Evidence for a role of geranylgeranylation in renal angiomyolipoma and renal epithelioid angiomyolipoma.
Overexpression of geranylgeranyl diphosphate synthase contributes to tumour metastasis and correlates with poor prognosis of lung adenocarcinoma.
Geranylgeranyl Diphosphate Synthase Modulates Fetal Lung Branching Morphogenesis Possibly through Controlling K-Ras Prenylation.
GGPPS1 predicts the biological character of hepatocellular carcinoma in patients with cirrhosis.
Deng Y, Guo C, Zhang T, Chen Y, Zhang X, Ji H, Hu L
International journal of cancer 2025 Nov 15;157(10):2173-2186
International journal of cancer 2025 Nov 15;157(10):2173-2186
ENKD1 modulates innate immune responses through enhanced geranylgeranyl pyrophosphate synthase activity.
Zhang T, Wang Y, Nie X, Chen X, Jin Y, Sun L, Yang R, Wang J, Xu W, Song T, Xie W, Chen X, Li C, Zhou J, Wu S, Li Y, Li T
Cell reports 2025 Mar 25;44(3):115397
Cell reports 2025 Mar 25;44(3):115397
Periodontal ligament fibroblasts utilize isoprenoid intermediate farnesyl diphosphate for maintaining osteo/cementogenic differentiation abilities.
Wang X, Suzuki S, Yuan H, Hirata-Tsuchiya S, Fahreza RR, Nemoto E, Shiba H, Yamada S
Journal of dental sciences 2025 Jan;20(1):560-568
Journal of dental sciences 2025 Jan;20(1):560-568
Deficiency of geranylgeranyl biphosphate synthase in kidney tubules causes cystic kidney disease.
Shao X, Wang K, Wu J, Ma X, Zhao Y, Xu T, Dai C, Zhang F, Wang Y, Ren X, Lu K, Yin Z, Guo B, Cao C, Xu X, Xue B
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Sep 15;38(17):e23875
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Sep 15;38(17):e23875
miR-612 Enhances RSL3-Induced Ferroptosis of Hepatocellular Carcinoma Cells via Mevalonate Pathway.
Xing K, Bian X, Shi D, Dong S, Zhou H, Xiao S, Bai J, Wu W
Journal of hepatocellular carcinoma 2023;10:2173-2185
Journal of hepatocellular carcinoma 2023;10:2173-2185
Quantitative proteomic profiling identifies global protein network dynamics in murine embryonic heart development.
Edwards W, Greco TM, Miner GE, Barker NK, Herring L, Cohen S, Cristea IM, Conlon FL
Developmental cell 2023 Jun 19;58(12):1087-1105.e4
Developmental cell 2023 Jun 19;58(12):1087-1105.e4
Therapeutic targeting of the mevalonate-geranylgeranyl diphosphate pathway with statins overcomes chemotherapy resistance in small cell lung cancer.
Guo C, Wan R, He Y, Lin SH, Cao J, Qiu Y, Zhang T, Zhao Q, Niu Y, Jin Y, Huang HY, Wang X, Tan L, Thomas RK, Zhang H, Chen L, Wong KK, Hu L, Ji H
Nature cancer 2022 May;3(5):614-628
Nature cancer 2022 May;3(5):614-628
Cysteine-Rich LIM-Only Protein 4 (CRP4) Promotes Atherogenesis in the ApoE(-/-) Mouse Model.
Längst N, Adler J, Kuret A, Peter A, Ruth P, Boldt K, Lukowski R
Cells 2022 Apr 17;11(8)
Cells 2022 Apr 17;11(8)
Geranylgeranyl diphosphate synthase 1 knockdown suppresses NLRP3 inflammasome activity via promoting autophagy in sepsis-induced acute lung injury.
Li D, Li C, Wang T, Zhang C, Zhu Z, Zhang G, Fang B
International immunopharmacology 2021 Nov;100:108106
International immunopharmacology 2021 Nov;100:108106
Conditional loss of geranylgeranyl diphosphate synthase alleviates acute obstructive cholestatic liver injury by regulating hepatic bile acid metabolism.
Jia WJ, Tang QL, Jiang S, Sun SQ, Xue B, Qiu YD, Li CJ, Mao L
The FEBS journal 2020 Aug;287(15):3328-3345
The FEBS journal 2020 Aug;287(15):3328-3345
Inhibition of GGPPS1 attenuated LPS-induced acute lung injury and was associated with NLRP3 inflammasome suppression.
Xu WJ, Wang XX, Jin JJ, Zou Q, Wu L, Lv TF, Wan B, Zhan P, Zhu SH, Liu HB, Zhao NW, Li CJ, Song Y
American journal of physiology. Lung cellular and molecular physiology 2019 Mar 1;316(3):L567-L577
American journal of physiology. Lung cellular and molecular physiology 2019 Mar 1;316(3):L567-L577
Evidence for a role of geranylgeranylation in renal angiomyolipoma and renal epithelioid angiomyolipoma.
Zhao DD, Yuan J, Cheng Q, Qi YL, Lu K, Lai SS, Sun Q, Zhao Y, Fang L, Jin ML, Yu DC, Qiu YD, Li CJ, Chen J, Xue B
Oncology letters 2019 Feb;17(2):1523-1530
Oncology letters 2019 Feb;17(2):1523-1530
Overexpression of geranylgeranyl diphosphate synthase contributes to tumour metastasis and correlates with poor prognosis of lung adenocarcinoma.
Wang X, Xu W, Zhan P, Xu T, Jin J, Miu Y, Zhou Z, Zhu Q, Wan B, Xi G, Ye L, Liu Y, Gao J, Li H, Lv T, Song Y
Journal of cellular and molecular medicine 2018 Apr;22(4):2177-2189
Journal of cellular and molecular medicine 2018 Apr;22(4):2177-2189
Geranylgeranyl Diphosphate Synthase Modulates Fetal Lung Branching Morphogenesis Possibly through Controlling K-Ras Prenylation.
Jia WJ, Jiang S, Tang QL, Shen D, Xue B, Ning W, Li CJ
The American journal of pathology 2016 Jun;186(6):1454-65
The American journal of pathology 2016 Jun;186(6):1454-65
GGPPS1 predicts the biological character of hepatocellular carcinoma in patients with cirrhosis.
Yu DC, Liu J, Chen J, Shao JJ, Shen X, Xia HG, Li CJ, Xue B, Ding YT
BMC cancer 2014 Apr 9;14:248
BMC cancer 2014 Apr 9;14:248
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 14944-1-AP(GGPS1 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 14944-1-AP(GGPS1 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The GGPS1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human GGPS1. This antibody recognizes human,mouse,rat antigen. The GGPS1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
