11375-1-AP

antibody from Proteintech Group

Targeting: FH

Provider product page for 11375-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [22]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [1]

Submit

Product number: 11375-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#11375-1-AP, RRID:AB_763171
Product name: FH antibody
Antibody type: Polyclonal
Description: FH antibody (Cat. #11375-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

FH protein structure - 11375-1-AP shown in red.

Submitted references sPLA2-IB and PLA2R Mediate Aberrant Glucose Metabolism in Podocytes via Hyperactivation of the mTOR/HIF-1α Pathway.

Bao J, Dai B, Yang L, Liu Z, Jin Y, Zhao H, Pan Y
Cell biochemistry and biophysics 2025 Sep;83(3):3341-3351

Disease-specific tau polymorphs define unique protein interaction networks across proteinopathies.

Puangmalai N, Bhatt N, Suthprasertporn N, Miranda-Morales EG, Shchankin N, Samples M, Balci AE, Liew JY, Montalbano M, Zhao Y, Kayed R
bioRxiv : the preprint server for biology 2025 Sep 15;

Succinate dehydrogenase activity supports de novo purine synthesis.

Nengroo MA, Klein AT, Carr HS, Vidal-Cruchez O, Sahu U, McGrail DJ, Sahni N, Gao P, Asara JM, Shah H, Mendillo ML, Ben-Sahra I
bioRxiv : the preprint server for biology 2025 Mar 1;

P4HB, a novel succinated protein, is essential for fumarate-induced cancer metastasis.

Song X, Rao H, Huang C, Huang M, Ma Y, Xin J, Hou J, Hu Z, He L, Pan F, Yang L, Guo Z
International journal of biological macromolecules 2025 Jun;311(Pt 3):143885

TAMs-derived SPP1, regulated by HIF-1α/STAT3 signaling pathway, influences colorectal cancer malignant progression by activation of EMT via integrin αvβ3.

Qu Y, Wang X, Li J, Luo H, Liu H, Wang T, Han X
International immunopharmacology 2025 Jun 26;159:114947

Eosinophilic Solid and Cystic Renal Cell Carcinoma: Morphologic and Immunohistochemical Study of 18 Cases and Review of the Literature.

Guo Q, Yao X, Yang B, Qi L, Wang F, Guo Y, Liu Y, Cao Z, Wang Y, Wang J, Li L, Huang Q, Liu C, Qu T, Zhao W, Ren D, Yang M, Yan C, Meng B, Wang C, Cao W
Archives of pathology & laboratory medicine 2024 Oct 1;148(10):1126-1134

Macrophage MCT4 inhibition activates reparative genes and protects from atherosclerosis by histone H3 lysine 18 lactylation.

Zhang Y, Jiang H, Dong M, Min J, He X, Tan Y, Liu F, Chen M, Chen X, Yin Q, Zheng L, Shao Y, Li X, Chen H
Cell reports 2024 May 28;43(5):114180

Testicular ACE regulates sperm metabolism and fertilization through the transcription factor PPARγ.

Shibata T, Bhat SA, Cao D, Saito S, Bernstein EA, Nishi E, Medenilla JD, Wang ET, Chan JL, Pisarska MD, Tourtellotte WG, Giani JF, Bernstein KE, Khan Z
The Journal of biological chemistry 2024 Jan;300(1):105486

Fumarate induces LncRNA-MIR4435-2HG to regulate glutamine metabolism remodeling and promote the development of FH-deficient renal cell carcinoma.

Zhu L, Hong Y, Zhu Z, Huang J, Wang J, Li G, Wu X, Chen Y, Xu Y, Zheng L, Huang Y, Kong W, Xue W, Zhang J
Cell death & disease 2024 Feb 19;15(2):151

Colorectal cancer cells establish metabolic reprogramming with cancer-associated fibroblasts (CAFs) through lactate shuttle to enhance invasion, migration, and angiogenesis.

Wang X, Qu Y, Ji J, Liu H, Luo H, Li J, Han X
International immunopharmacology 2024 Dec 25;143(Pt 2):113470

Inhibition of fatty acid oxidation enables heart regeneration in adult mice.

Li X, Wu F, Günther S, Looso M, Kuenne C, Zhang T, Wiesnet M, Klatt S, Zukunft S, Fleming I, Poschet G, Wietelmann A, Atzberger A, Potente M, Yuan X, Braun T
Nature 2023 Oct;622(7983):619-626

Albumosomes formed by cytoplasmic pre-folding albumin maintain mitochondrial homeostasis and inhibit nonalcoholic fatty liver disease.

Ma B, Ju A, Zhang S, An Q, Xu S, Liu J, Yu L, Fu Y, Luo Y
Signal transduction and targeted therapy 2023 Jun 16;8(1):229

Circulating succinate-modifying metabolites accurately classify and reflect the status of fumarate hydratase-deficient renal cell carcinoma.

Zheng L, Zhu ZR, Sneh T, Zhang WT, Wang ZY, Wu GY, He W, Qi HG, Wang H, Wu XY, Fernández-García J, Abramovich I, Xu YZ, Zhang J, Gottlieb E
The Journal of clinical investigation 2023 Jun 1;133(11)

Dietary Salt Disrupts Tricarboxylic Acid Cycle and Induces Tau Hyperphosphorylation and Synapse Dysfunction during Aging.

Yuan M, Wang Y, Wen J, Jing F, Zou Q, Pu Y, Pan T, Cai Z
Aging and disease 2022 Oct 1;13(5):1532-1545

Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues.

Fan TW, Daneshmandi S, Cassel TA, Uddin MB, Sledziona J, Thompson PT, Lin P, Higashi RM, Lane AN
Journal of immunology (Baltimore, Md. : 1950) 2022 Nov 1;209(9):1674-1690

EBV(LMP1)-induced metabolic reprogramming inhibits necroptosis through the hypermethylation of the RIP3 promoter.

Shi F, Zhou M, Shang L, Du Q, Li Y, Xie L, Liu X, Tang M, Luo X, Fan J, Zhou J, Gao Q, Qiu S, Wu W, Zhang X, Bode AM, Cao Y
Theranostics 2019;9(9):2424-2438

Anti-senescence role of heterozygous fumarate hydratase gene knockout in rat lung fibroblasts in vitro.

Fan Z, Li L, Li X, Zhang M, Dou M, Zhao J, Cao J, Deng X, Zhang M, Li H, Suo Z
Aging 2019 Jan 21;11(2):573-589

Coupling of oxidative stress responses to tricarboxylic acid cycle and prostaglandin E(2) alterations in Caenorhabditis elegans under extremely low-frequency electromagnetic field.

Sun Y, Shi Z, Wang Y, Tang C, Liao Y, Yang C, Cai P
International journal of radiation biology 2018 Dec;94(12):1159-1166

CDC5L drives FAH expression to promote metabolic reprogramming in melanoma.

Gu Z, Zhang H, Li Y, Shen S, Yin X, Zhang W, Cheng R, Zhang Y, Zhang X, Chen H, Huang B, Cao Y
Oncotarget 2017 Dec 26;8(69):114328-114343

Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1.

Ma X, Li C, Sun L, Huang D, Li T, He X, Wu G, Yang Z, Zhong X, Song L, Gao P, Zhang H
Nature communications 2014 Oct 10;5:5212

Bioinformatics analysis and expression study of fumarate hydratase in lung cancer.

Ming Z, Jiang M, Li W, Fan N, Deng W, Zhong Y, Zhang Y, Zhang Q, Yang S
Thoracic cancer 2014 Nov;5(6):543-9

Proteomics of uveal melanomas suggests HSP-27 as a possible surrogate marker of chromosome 3 loss.

Coupland SE, Vorum H, Mandal N, Kalirai H, Honoré B, Urbak SF, Lake SL, Dopierala J, Damato B
Investigative ophthalmology & visual science 2010 Jan;51(1):12-20

No comments: Submit comment

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 11375-1-AP(FH antibody) at dilution of 1:1000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The FH antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human FH. This antibody recognizes human, mouse, rat antigen. The FH antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 11375-1-AP.pdf

: Show more