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- Antibody Data
- Antigen structure
- References [14]
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- Western blot [2]
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- Product number
- NB300-118 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB300-118, RRID:AB_10002447
- Product name
- Mouse Monoclonal NMDAR1 Antibody
- Antibody type
- Monoclonal
- Description
- Tissue culture supernatant. Specific for the ~120k NR1 subunit of the NMDA receptor.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Isotype
- IgG
- Vial size
- 0.015 mg
- Concentration
- LYOPH
- Storage
- Store at -20C. Avoid freeze-thaw cycles.
Submitted references Identification and therapeutic rescue of autophagosome and glutamate receptor defects in C9ORF72 and sporadic ALS neurons.
Loss of Frrs1l disrupts synaptic AMPA receptor function, and results in neurodevelopmental, motor, cognitive and electrographical abnormalities.
Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons.
2-methoxyestradiol impacts on amino acids-mediated metabolic reprogramming in osteosarcoma cells by its interaction with NMDA receptor.
Spontaneous Glutamatergic Synaptic Activity Regulates Constitutive COX-2 Expression in Neurons: OPPOSING ROLES FOR THE TRANSCRIPTION FACTORS CREB (cAMP RESPONSE ELEMENT BINDING) PROTEIN AND Sp1 (STIMULATORY PROTEIN-1).
Notch1 Regulates Hippocampal Plasticity Through Interaction with the Reelin Pathway, Glutamatergic Transmission and CREB Signaling.
An investigation of interactions between hypocretin/orexin signaling and glutamate receptor surface expression in the rat nucleus accumbens under basal conditions and after cocaine exposure.
Distribution of AMPA receptor subunits and TARPs in synaptic and extrasynaptic membranes of the adult rat nucleus accumbens.
Dextromethorphan attenuated the higher vulnerability to inflammatory thermal hyperalgesia caused by prenatal morphine exposure in rat offspring.
NMDA receptors are expressed in lymphocytes activated both in vitro and in vivo.
siRNA-mediated knockdown of the NR1 subunit gene of the NMDA receptor attenuates formalin-induced pain behaviors in adult rats.
Expression of spinal NMDA receptor and PKCgamma after chronic morphine is regulated by spinal glucocorticoid receptor.
Differential alterations in the expression of NMDA receptor subunits following chronic ethanol treatment in primary cultures of rat cortical and hippocampal neurones.
Differential alterations in the expression of NMDA receptor subunits following chronic ethanol treatment in primary cultures of rat cortical and hippocampal neurones.
Shi Y, Hung ST, Rocha G, Lin S, Linares GR, Staats KA, Seah C, Wang Y, Chickering M, Lai J, Sugawara T, Sagare AP, Zlokovic BV, Ichida JK
JCI insight 2019 Jul 16;5
JCI insight 2019 Jul 16;5
Loss of Frrs1l disrupts synaptic AMPA receptor function, and results in neurodevelopmental, motor, cognitive and electrographical abnormalities.
Stewart M, Lau P, Banks G, Bains RS, Castroflorio E, Oliver PL, Dixon CL, Kruer MC, Kullmann DM, Acevedo-Arozena A, Wells SE, Corrochano S, Nolan PM
Disease models & mechanisms 2019 Feb 22;12(2)
Disease models & mechanisms 2019 Feb 22;12(2)
Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons.
Shi Y, Lin S, Staats KA, Li Y, Chang WH, Hung ST, Hendricks E, Linares GR, Wang Y, Son EY, Wen X, Kisler K, Wilkinson B, Menendez L, Sugawara T, Woolwine P, Huang M, Cowan MJ, Ge B, Koutsodendris N, Sandor KP, Komberg J, Vangoor VR, Senthilkumar K, Hennes V, Seah C, Nelson AR, Cheng TY, Lee SJ, August PR, Chen JA, Wisniewski N, Hanson-Smith V, Belgard TG, Zhang A, Coba M, Grunseich C, Ward ME, van den Berg LH, Pasterkamp RJ, Trotti D, Zlokovic BV, Ichida JK
Nature medicine 2018 Mar;24(3):313-325
Nature medicine 2018 Mar;24(3):313-325
2-methoxyestradiol impacts on amino acids-mediated metabolic reprogramming in osteosarcoma cells by its interaction with NMDA receptor.
Gorska-Ponikowska M, Perricone U, Kuban-Jankowska A, Lo Bosco G, Barone G
Journal of cellular physiology 2017 Nov;232(11):3030-3049
Journal of cellular physiology 2017 Nov;232(11):3030-3049
Spontaneous Glutamatergic Synaptic Activity Regulates Constitutive COX-2 Expression in Neurons: OPPOSING ROLES FOR THE TRANSCRIPTION FACTORS CREB (cAMP RESPONSE ELEMENT BINDING) PROTEIN AND Sp1 (STIMULATORY PROTEIN-1).
Hewett SJ, Shi J, Gong Y, Dhandapani K, Pilbeam C, Hewett JA
The Journal of biological chemistry 2016 Dec 30;291(53):27279-27288
The Journal of biological chemistry 2016 Dec 30;291(53):27279-27288
Notch1 Regulates Hippocampal Plasticity Through Interaction with the Reelin Pathway, Glutamatergic Transmission and CREB Signaling.
Brai E, Marathe S, Astori S, Fredj NB, Perry E, Lamy C, Scotti A, Alberi L
Frontiers in cellular neuroscience 2015;9:447
Frontiers in cellular neuroscience 2015;9:447
An investigation of interactions between hypocretin/orexin signaling and glutamate receptor surface expression in the rat nucleus accumbens under basal conditions and after cocaine exposure.
Plaza-Zabala A, Li X, Milovanovic M, Loweth JA, Maldonado R, Berrendero F, Wolf ME
Neuroscience letters 2013 Dec 17;557 Pt B(0 0):101-6
Neuroscience letters 2013 Dec 17;557 Pt B(0 0):101-6
Distribution of AMPA receptor subunits and TARPs in synaptic and extrasynaptic membranes of the adult rat nucleus accumbens.
Ferrario CR, Loweth JA, Milovanovic M, Wang X, Wolf ME
Neuroscience letters 2011 Mar 3;490(3):180-4
Neuroscience letters 2011 Mar 3;490(3):180-4
Dextromethorphan attenuated the higher vulnerability to inflammatory thermal hyperalgesia caused by prenatal morphine exposure in rat offspring.
Tao PL, Chen CF, Huang EY
Journal of biomedical science 2011 Aug 23;18:64
Journal of biomedical science 2011 Aug 23;18:64
NMDA receptors are expressed in lymphocytes activated both in vitro and in vivo.
Mashkina AP, Cizkova D, Vanicky I, Boldyrev AA
Cellular and molecular neurobiology 2010 Aug;30(6):901-7
Cellular and molecular neurobiology 2010 Aug;30(6):901-7
siRNA-mediated knockdown of the NR1 subunit gene of the NMDA receptor attenuates formalin-induced pain behaviors in adult rats.
Garraway SM, Xu Q, Inturrisi CE
The journal of pain 2009 Apr;10(4):380-90
The journal of pain 2009 Apr;10(4):380-90
Expression of spinal NMDA receptor and PKCgamma after chronic morphine is regulated by spinal glucocorticoid receptor.
Lim G, Wang S, Zeng Q, Sung B, Yang L, Mao J
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005 Nov 30;25(48):11145-54
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005 Nov 30;25(48):11145-54
Differential alterations in the expression of NMDA receptor subunits following chronic ethanol treatment in primary cultures of rat cortical and hippocampal neurones.
Nagy J, Kolok S, Dezso P, Boros A, Szombathelyi Z
Neurochemistry international 2003 Jan;42(1):35-43
Neurochemistry international 2003 Jan;42(1):35-43
Differential alterations in the expression of NMDA receptor subunits following chronic ethanol treatment in primary cultures of rat cortical and hippocampal neurones.
Nagy J, Kolok S, Dezso P, Boros A, Szombathelyi Z
Neurochemistry international 2003 Jan;42(1):35-43
Neurochemistry international 2003 Jan;42(1):35-43
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: NMDAR1 Antibody (R1JHL) [NB300-118] - 10 ug of rat hippocampal lysate showing specific immunolabeling of the ~120 kDa NR1 subunit of the NMDA receptor.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: NMDAR1 Antibody (R1JHL) [NB300-118] - The blots show the examples of immunobands against NMDAR1 and beta-actin antibodies on the membrane, which was performed on the membrane protein prepared from the lumbar spinal cords of the offspring (P14) rats in different groups. Image collected and cropped by CiteAb from the following publication (http://www.jbiomedsci.com/content/18/1/64) licensed under a CC-BY licence.
