BS1783

antibody from Bioworld Technology, Inc
Targeting: RYR2 ARVC2, ARVD2, VTSIP
Provider product page for BS1783
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS1783 - Provider product page
Provider
Bioworld Technology, Inc
Proper citation
Bioworld Technology Cat#BS1783, RRID:AB_1662096
Product name
RyR2 (N2802) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic peptide, corresponding to amino acids 2770-2821of Human RyR2.
Description
Dihydropyridine receptor (DHPR) is a surface membrane protein critical for the excitation-contraction coupling of striated muscle. DHPR and the sarcoplasmic reticulum ryanodine receptor (RyR) are two key components of the intracellular junctions, where depolarization of the surface membrane is converted into the release of Ca2+ from internal stores. The Ï«1-subunit of the DHPR contains a cytoplasmic loop which is thought to be involved in the interactions with RyR. Phosphorylation of the DHPR Ï«1-subunit is also thought to play a role in the functional interaction of DHPR and RyR. Mutation in DHPR Ï«1 results in excitation-contraction uncoupling, leading to muscular dysgenesis, a complete inactivity in developing skeletal muscles. Cells that do not express RyR also lack excitation-contraction coupling and exhibit a severalfold reduction in Ca2+ current density.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
RYR2 protein structure - BS1783 shown in red.