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- Antibody Data
- Antigen structure
- References [25]
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- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 19765-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#19765-1-AP, RRID:AB_10637859
- Product name
- RYR2 antibody
- Antibody type
- Polyclonal
- Description
- RYR2 antibody (Cat. #19765-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Dynamin-related protein 1 is a critical regulator of mitochondrial calcium homeostasis during myocardial ischemia/reperfusion injury.
Zbtb16 increases susceptibility of atrial fibrillation in type 2 diabetic mice via Txnip-Trx2 signaling.
LncRNA CCRR maintains Ca(2+) homeostasis against myocardial infarction through the FTO-SERCA2a pathway.
Maternal exercise preserves offspring cardiovascular health via oxidative regulation of the ryanodine receptor.
Echinacoside Induces UCP1- and ATP-Dependent Thermogenesis in Beige Adipocytes via the Activation of Dopaminergic Receptors.
Whole exome sequencing in unexplained recurrent miscarriage families identified novel pathogenic genetic causes of euploid miscarriage.
Dopamine receptor D4 (DRD4) negatively regulates UCP1- and ATP-dependent thermogenesis in 3T3-L1 adipocytes and C2C12 muscle cells.
Patient-specific induced pluripotent stem cell properties implicate Ca(2+)-homeostasis in clinical arrhythmia associated with combined heterozygous RYR2 and SCN10A variants.
Ryanodine receptor 2 promotes colorectal cancer metastasis by the ROS/BACH1 axis.
Elevated Ca(2+) at the triad junction underlies dysregulation of Ca(2+) signaling in dysferlin-null skeletal muscle.
Oxidative stress activates Ryr2-Ca(2+) and apoptosis to promote PM(2.5)-induced heart injury of hyperlipidemia mice.
IL-6/STAT3 Signaling Promotes Cardiac Dysfunction by Upregulating FUNDC1-Dependent Mitochondria-Associated Endoplasmic Reticulum Membranes Formation in Sepsis Mice.
Fibroblast Growth Factor 21 Protects Against Atrial Remodeling via Reducing Oxidative Stress.
Endoplasmic Reticulum Stress/Ca(2+)-Calmodulin-Dependent Protein Kinase/Signal Transducer and Activator of Transcription 3 Pathway Plays a Role in the Regulation of Cellular Zinc Deficiency in Myocardial Ischemia/Reperfusion Injury.
Arsenic (III) and/or Antimony (III) induced disruption of calcium homeostasis and endoplasmic reticulum stress resulting in apoptosis in mice heart.
Applying cooperative module pair analysis to uncover compatibility mechanism of Fangjis: An example of Wenxin Keli decoction.
Loss of Camk2n1 aggravates cardiac remodeling and malignant ventricular arrhythmia after myocardial infarction in mice via NLRP3 inflammasome activation.
Direct Cardiac Actions of the Sodium Glucose Co-Transporter 2 Inhibitor Empagliflozin Improve Myocardial Oxidative Phosphorylation and Attenuate Pressure-Overload Heart Failure.
SERCA2a ameliorates cardiomyocyte T-tubule remodeling via the calpain/JPH2 pathway to improve cardiac function in myocardial ischemia/reperfusion mice.
Oxygenated polycyclic aromatic hydrocarbons from ambient particulate matter induce electrophysiological instability in cardiomyocytes.
Astragaloside IV attenuates chronic intermittent hypoxia-induced myocardial injury by modulating Ca(2+) homeostasis.
Atrial fibrillation and its arrhythmogenesis associated with insulin resistance.
Tachycardia-induced CD44/NOX4 signaling is involved in the development of atrial remodeling.
The harmful effects of acute PM(2.5) exposure to the heart and a novel preventive and therapeutic function of CEOs.
Protective role of heme oxygenase-1 in atrial remodeling.
Piao L, Fang YH, Fisher M, Hamanaka RB, Ousta A, Wu R, Mutlu GM, Garcia AJ 3rd, Archer SL, Sharp WW
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan;38(1):e23379
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan;38(1):e23379
Zbtb16 increases susceptibility of atrial fibrillation in type 2 diabetic mice via Txnip-Trx2 signaling.
Wei ZX, Cai XX, Fei YD, Wang Q, Hu XL, Li C, Hou JW, Yang YL, Chen TZ, Xu XL, Wang YP, Li YG
Cellular and molecular life sciences : CMLS 2024 Feb 13;81(1):88
Cellular and molecular life sciences : CMLS 2024 Feb 13;81(1):88
LncRNA CCRR maintains Ca(2+) homeostasis against myocardial infarction through the FTO-SERCA2a pathway.
Yang H, Xuan L, Wang S, Luo H, Duan X, Guo J, Cui S, Xin J, Hao J, Li X, Chen J, Sun F, Hu X, Li S, Zhang Y, Jiao L, Yang B, Sun L
Science China. Life sciences 2024 Aug;67(8):1601-1619
Science China. Life sciences 2024 Aug;67(8):1601-1619
Maternal exercise preserves offspring cardiovascular health via oxidative regulation of the ryanodine receptor.
Pinckard KM, Félix-Soriano E, Hamilton S, Terentyeva R, Baer LA, Wright KR, Nassal D, Esteves JV, Abay E, Shettigar VK, Ziolo MT, Hund TJ, Wold LE, Terentyev D, Stanford KI
Molecular metabolism 2024 Apr;82:101914
Molecular metabolism 2024 Apr;82:101914
Echinacoside Induces UCP1- and ATP-Dependent Thermogenesis in Beige Adipocytes via the Activation of Dopaminergic Receptors.
Haddish K, Yun JW
Journal of microbiology and biotechnology 2023 Oct 28;33(10):1268-1280
Journal of microbiology and biotechnology 2023 Oct 28;33(10):1268-1280
Whole exome sequencing in unexplained recurrent miscarriage families identified novel pathogenic genetic causes of euploid miscarriage.
Wang X, Shi W, Zhao S, Gong D, Li S, Hu C, Chen ZJ, Li Y, Yan J
Human reproduction (Oxford, England) 2023 May 2;38(5):1003-1018
Human reproduction (Oxford, England) 2023 May 2;38(5):1003-1018
Dopamine receptor D4 (DRD4) negatively regulates UCP1- and ATP-dependent thermogenesis in 3T3-L1 adipocytes and C2C12 muscle cells.
Haddish K, Yun JW
Pflugers Archiv : European journal of physiology 2023 Jun;475(6):757-773
Pflugers Archiv : European journal of physiology 2023 Jun;475(6):757-773
Patient-specific induced pluripotent stem cell properties implicate Ca(2+)-homeostasis in clinical arrhythmia associated with combined heterozygous RYR2 and SCN10A variants.
Zhou Y, Huang W, Liu L, Li A, Jiang C, Zhou R, Wang J, Tan X, Huang CL, Zhang Y
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2023 Jun 19;378(1879):20220175
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2023 Jun 19;378(1879):20220175
Ryanodine receptor 2 promotes colorectal cancer metastasis by the ROS/BACH1 axis.
Chen T, Zhang X, Ding X, Feng J, Zhang X, Xie D, Wang X
Molecular oncology 2023 Apr;17(4):695-709
Molecular oncology 2023 Apr;17(4):695-709
Elevated Ca(2+) at the triad junction underlies dysregulation of Ca(2+) signaling in dysferlin-null skeletal muscle.
Lukyanenko V, Muriel J, Garman D, Breydo L, Bloch RJ
Frontiers in physiology 2022;13:1032447
Frontiers in physiology 2022;13:1032447
Oxidative stress activates Ryr2-Ca(2+) and apoptosis to promote PM(2.5)-induced heart injury of hyperlipidemia mice.
Meng M, Jia R, Wei M, Meng X, Zhang X, Du R, Sun W, Wang L, Song L
Ecotoxicology and environmental safety 2022 Mar 1;232:113228
Ecotoxicology and environmental safety 2022 Mar 1;232:113228
IL-6/STAT3 Signaling Promotes Cardiac Dysfunction by Upregulating FUNDC1-Dependent Mitochondria-Associated Endoplasmic Reticulum Membranes Formation in Sepsis Mice.
Jiang T, Peng D, Shi W, Guo J, Huo S, Men L, Zhang C, Li S, Lv J, Lin L
Frontiers in cardiovascular medicine 2021;8:790612
Frontiers in cardiovascular medicine 2021;8:790612
Fibroblast Growth Factor 21 Protects Against Atrial Remodeling via Reducing Oxidative Stress.
Chen M, Zhong J, Wang Z, Xu H, Chen H, Sun X, Lu Y, Chen L, Xie X, Zheng L
Frontiers in cardiovascular medicine 2021;8:720581
Frontiers in cardiovascular medicine 2021;8:720581
Endoplasmic Reticulum Stress/Ca(2+)-Calmodulin-Dependent Protein Kinase/Signal Transducer and Activator of Transcription 3 Pathway Plays a Role in the Regulation of Cellular Zinc Deficiency in Myocardial Ischemia/Reperfusion Injury.
Zhao H, Liu D, Yan Q, Bian X, Yu J, Wang J, Cheng X, Xu Z
Frontiers in physiology 2021;12:736920
Frontiers in physiology 2021;12:736920
Arsenic (III) and/or Antimony (III) induced disruption of calcium homeostasis and endoplasmic reticulum stress resulting in apoptosis in mice heart.
Jiang X, Yu W, Wu S, Tang L, Zhong G, Wan F, Lan J, Zhang H, Pan J, Tang Z, Zhang X, Hu L, Huang R
Ecotoxicology and environmental safety 2021 Sep 1;220:112394
Ecotoxicology and environmental safety 2021 Sep 1;220:112394
Applying cooperative module pair analysis to uncover compatibility mechanism of Fangjis: An example of Wenxin Keli decoction.
Wang P, He T, Zheng R, Sun Y, Qiu R, Zhang X, Xing Y, Shang H
Journal of ethnopharmacology 2021 Oct 5;278:114214
Journal of ethnopharmacology 2021 Oct 5;278:114214
Loss of Camk2n1 aggravates cardiac remodeling and malignant ventricular arrhythmia after myocardial infarction in mice via NLRP3 inflammasome activation.
Wei Z, Fei Y, Wang Q, Hou J, Cai X, Yang Y, Chen T, Xu Q, Wang Y, Li YG
Free radical biology & medicine 2021 May 1;167:243-257
Free radical biology & medicine 2021 May 1;167:243-257
Direct Cardiac Actions of the Sodium Glucose Co-Transporter 2 Inhibitor Empagliflozin Improve Myocardial Oxidative Phosphorylation and Attenuate Pressure-Overload Heart Failure.
Li X, Lu Q, Qiu Y, do Carmo JM, Wang Z, da Silva AA, Mouton A, Omoto ACM, Hall ME, Li J, Hall JE
Journal of the American Heart Association 2021 Mar 16;10(6):e018298
Journal of the American Heart Association 2021 Mar 16;10(6):e018298
SERCA2a ameliorates cardiomyocyte T-tubule remodeling via the calpain/JPH2 pathway to improve cardiac function in myocardial ischemia/reperfusion mice.
Wang S, Zhou Y, Luo Y, Kan R, Chen J, Xuan H, Wang C, Chen J, Xu T, Li D
Scientific reports 2021 Jan 21;11(1):2037
Scientific reports 2021 Jan 21;11(1):2037
Oxygenated polycyclic aromatic hydrocarbons from ambient particulate matter induce electrophysiological instability in cardiomyocytes.
Ju S, Lim L, Jiao HY, Choi S, Jun JY, Ki YJ, Choi DH, Lee JY, Song H
Particle and fibre toxicology 2020 Jun 11;17(1):25
Particle and fibre toxicology 2020 Jun 11;17(1):25
Astragaloside IV attenuates chronic intermittent hypoxia-induced myocardial injury by modulating Ca(2+) homeostasis.
Jiang S, Jiao G, Chen Y, Han M, Wang X, Liu W
Cell biochemistry and function 2020 Aug;38(6):710-720
Cell biochemistry and function 2020 Aug;38(6):710-720
Atrial fibrillation and its arrhythmogenesis associated with insulin resistance.
Chan YH, Chang GJ, Lai YJ, Chen WJ, Chang SH, Hung LM, Kuo CT, Yeh YH
Cardiovascular diabetology 2019 Sep 26;18(1):125
Cardiovascular diabetology 2019 Sep 26;18(1):125
Tachycardia-induced CD44/NOX4 signaling is involved in the development of atrial remodeling.
Chen WJ, Chang SH, Chan YH, Lee JL, Lai YJ, Chang GJ, Tsai FC, Yeh YH
Journal of molecular and cellular cardiology 2019 Oct;135:67-78
Journal of molecular and cellular cardiology 2019 Oct;135:67-78
The harmful effects of acute PM(2.5) exposure to the heart and a novel preventive and therapeutic function of CEOs.
Dong L, Sun W, Li F, Shi M, Meng X, Wang C, Meng M, Tang W, Liu H, Wang L, Song L
Scientific reports 2019 Mar 5;9(1):3495
Scientific reports 2019 Mar 5;9(1):3495
Protective role of heme oxygenase-1 in atrial remodeling.
Yeh YH, Hsu LA, Chen YH, Kuo CT, Chang GJ, Chen WJ
Basic research in cardiology 2016 Sep;111(5):58
Basic research in cardiology 2016 Sep;111(5):58
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 19765-1-AP(RYR2 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Ryanodine Receptor 2 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human Ryanodine Receptor 2. This antibody recognizes human, mouse antigen. The Ryanodine Receptor 2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
