19765-1-AP

antibody from Proteintech Group

Targeting: RYR2 ARVC2, ARVD2, VTSIP

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

19765-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#19765-1-AP, RRID:AB_10637859

Product name

RYR2 antibody

Antibody type

Polyclonal

Description

RYR2 antibody (Cat. #19765-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB,ELISA.

Reactivity

Human, Mouse

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Divaroside alleviates barium chloride-induced arrhythmia by activating the Nrf2/HO-1 axis to modulate autophagy and calcium homeostasis.

Zhang C, Huang S, Zhang W, Teng H, Shao Y, Zhang Y, Ren S, Wu Q, Zhao Y, Yan Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158149

---

Spatial Transcriptional Heterogeneity in the Infarct Core and Its Surrounding Regions Targeting Piezo1 Signals in Rats With Myocardial Ischemia-Reperfusion Injury.

Li Z, Jiang F, Chen Y, Li Z, Wu Y, He Z, Wu D, Xiang H
MedComm 2026 Jan;7(1):e70537

---

NAT10 regulates heart development and function by maintaining the expression of genes related to fatty acid β-oxidation and heart contraction.

Shi L, Zhang M, Yang H, Li X, He S, Chu Y, Gao M, Zhang Z, Zhang JZ, Li Z, Chen Z
Cell death and differentiation 2026 Feb;33(2):358-373

---

Layer-specific proteomic analysis of human hearts in patients with sudden cardiac death.

Kakimoto Y, Guan X, Ueda A, Kimura Y, Akiyama T, Tanaka M, Ikeda H, Maeda K, Isozaki S
PloS one 2025;20(12):e0339886

---

Osmotic pressure-induced calcium response states.

Gao Z, Naruse K, Morimatsu M
FEBS open bio 2025 Oct;15(10):1714-1722

---

Pioglitazone mitigates high-fat diet-induced cardiac lipotoxicity and vulnerable arrhythmias by reducing excess lipid intermediates.

Yeh YH, Cheng ML, Yang CH, Chen WJ, Chan YH
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Nov;192:118672

---

The selenocysteine-containing protein SELENOT maintains dopamine signaling in the midbrain to protect mice from hyperactivity disorder.

Guo Q, Li ZF, Hu DY, Li PJ, Wu KN, Fan HH, Deng J, Wu HM, Zhang X, Zhu JH
The EMBO journal 2025 May;44(10):2906-2927

---

Intranasal Delivery of Lithium Salt Suppresses Inflammatory Pyroptosis in the Brain and Ameliorates Memory Loss and Depression-like Behavior in 5XFAD Mice.

Bhuiyan P, Zhang W, Liang G, Jiang B, Vera R, Chae R, Kim K, Louis LS, Wang Y, Liu J, Chuang DM, Wei H
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2025 Mar 17;20(1):26

---

Subcellular activation of β-adrenergic receptors using a spatially restricted antagonist.

Liccardo F, Morstein J, Lin TY, Pampel J, Lang D, Shokat KM, Irannejad R
Proceedings of the National Academy of Sciences of the United States of America 2024 Oct;121(40):e2404243121

---

Intranasal dantrolene nanoparticles inhibit inflammatory pyroptosis in 5XFAD mice brains.

Bhuiyan P, Zhang W, Chae R, Kim K, St Louis L, Wang Y, Liang G, Wei H
bioRxiv : the preprint server for biology 2024 Nov 25;

---

Dynamin-related protein 1 is a critical regulator of mitochondrial calcium homeostasis during myocardial ischemia/reperfusion injury.

Piao L, Fang YH, Fisher M, Hamanaka RB, Ousta A, Wu R, Mutlu GM, Garcia AJ 3rd, Archer SL, Sharp WW
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan;38(1):e23379

---

Zbtb16 increases susceptibility of atrial fibrillation in type 2 diabetic mice via Txnip-Trx2 signaling.

Wei ZX, Cai XX, Fei YD, Wang Q, Hu XL, Li C, Hou JW, Yang YL, Chen TZ, Xu XL, Wang YP, Li YG
Cellular and molecular life sciences : CMLS 2024 Feb 13;81(1):88

---

Intranasal Delivery of Lithium Salt Suppresses Inflammatory Pyroptosis in the brain and Ameliorates Memory Loss and Depression-like Behavior in 5XFAD mice.

Bhuiyan P, Zhang W, Liang G, Jiang B, Vera R, Chae R, Kim K, Louis LS, Wang Y, Liu J, Chuang DM, Wei H
bioRxiv : the preprint server for biology 2024 Dec 12;

---

LncRNA CCRR maintains Ca(2+) homeostasis against myocardial infarction through the FTO-SERCA2a pathway.

Yang H, Xuan L, Wang S, Luo H, Duan X, Guo J, Cui S, Xin J, Hao J, Li X, Chen J, Sun F, Hu X, Li S, Zhang Y, Jiao L, Yang B, Sun L
Science China. Life sciences 2024 Aug;67(8):1601-1619

---

Maternal exercise preserves offspring cardiovascular health via oxidative regulation of the ryanodine receptor.

Pinckard KM, Félix-Soriano E, Hamilton S, Terentyeva R, Baer LA, Wright KR, Nassal D, Esteves JV, Abay E, Shettigar VK, Ziolo MT, Hund TJ, Wold LE, Terentyev D, Stanford KI
Molecular metabolism 2024 Apr;82:101914

---

Echinacoside Induces UCP1- and ATP-Dependent Thermogenesis in Beige Adipocytes via the Activation of Dopaminergic Receptors.

Haddish K, Yun JW
Journal of microbiology and biotechnology 2023 Oct 28;33(10):1268-1280

---

Whole exome sequencing in unexplained recurrent miscarriage families identified novel pathogenic genetic causes of euploid miscarriage.

Wang X, Shi W, Zhao S, Gong D, Li S, Hu C, Chen ZJ, Li Y, Yan J
Human reproduction (Oxford, England) 2023 May 2;38(5):1003-1018

---

Dopamine receptor D4 (DRD4) negatively regulates UCP1- and ATP-dependent thermogenesis in 3T3-L1 adipocytes and C2C12 muscle cells.

Haddish K, Yun JW
Pflugers Archiv : European journal of physiology 2023 Jun;475(6):757-773

---

Patient-specific induced pluripotent stem cell properties implicate Ca(2+)-homeostasis in clinical arrhythmia associated with combined heterozygous RYR2 and SCN10A variants.

Zhou Y, Huang W, Liu L, Li A, Jiang C, Zhou R, Wang J, Tan X, Huang CL, Zhang Y
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2023 Jun 19;378(1879):20220175

---

Ryanodine receptor 2 promotes colorectal cancer metastasis by the ROS/BACH1 axis.

Chen T, Zhang X, Ding X, Feng J, Zhang X, Xie D, Wang X
Molecular oncology 2023 Apr;17(4):695-709

---

Elevated Ca(2+) at the triad junction underlies dysregulation of Ca(2+) signaling in dysferlin-null skeletal muscle.

Lukyanenko V, Muriel J, Garman D, Breydo L, Bloch RJ
Frontiers in physiology 2022;13:1032447

---

Oxidative stress activates Ryr2-Ca(2+) and apoptosis to promote PM(2.5)-induced heart injury of hyperlipidemia mice.

Meng M, Jia R, Wei M, Meng X, Zhang X, Du R, Sun W, Wang L, Song L
Ecotoxicology and environmental safety 2022 Mar 1;232:113228

---

IL-6/STAT3 Signaling Promotes Cardiac Dysfunction by Upregulating FUNDC1-Dependent Mitochondria-Associated Endoplasmic Reticulum Membranes Formation in Sepsis Mice.

Jiang T, Peng D, Shi W, Guo J, Huo S, Men L, Zhang C, Li S, Lv J, Lin L
Frontiers in cardiovascular medicine 2021;8:790612

---

Fibroblast Growth Factor 21 Protects Against Atrial Remodeling via Reducing Oxidative Stress.

Chen M, Zhong J, Wang Z, Xu H, Chen H, Sun X, Lu Y, Chen L, Xie X, Zheng L
Frontiers in cardiovascular medicine 2021;8:720581

---

Endoplasmic Reticulum Stress/Ca(2+)-Calmodulin-Dependent Protein Kinase/Signal Transducer and Activator of Transcription 3 Pathway Plays a Role in the Regulation of Cellular Zinc Deficiency in Myocardial Ischemia/Reperfusion Injury.

Zhao H, Liu D, Yan Q, Bian X, Yu J, Wang J, Cheng X, Xu Z
Frontiers in physiology 2021;12:736920

---

Arsenic (III) and/or Antimony (III) induced disruption of calcium homeostasis and endoplasmic reticulum stress resulting in apoptosis in mice heart.

Jiang X, Yu W, Wu S, Tang L, Zhong G, Wan F, Lan J, Zhang H, Pan J, Tang Z, Zhang X, Hu L, Huang R
Ecotoxicology and environmental safety 2021 Sep 1;220:112394

---

Applying cooperative module pair analysis to uncover compatibility mechanism of Fangjis: An example of Wenxin Keli decoction.

Wang P, He T, Zheng R, Sun Y, Qiu R, Zhang X, Xing Y, Shang H
Journal of ethnopharmacology 2021 Oct 5;278:114214

---

Loss of Camk2n1 aggravates cardiac remodeling and malignant ventricular arrhythmia after myocardial infarction in mice via NLRP3 inflammasome activation.

Wei Z, Fei Y, Wang Q, Hou J, Cai X, Yang Y, Chen T, Xu Q, Wang Y, Li YG
Free radical biology & medicine 2021 May 1;167:243-257

---

Direct Cardiac Actions of the Sodium Glucose Co-Transporter 2 Inhibitor Empagliflozin Improve Myocardial Oxidative Phosphorylation and Attenuate Pressure-Overload Heart Failure.

Li X, Lu Q, Qiu Y, do Carmo JM, Wang Z, da Silva AA, Mouton A, Omoto ACM, Hall ME, Li J, Hall JE
Journal of the American Heart Association 2021 Mar 16;10(6):e018298

---

SERCA2a ameliorates cardiomyocyte T-tubule remodeling via the calpain/JPH2 pathway to improve cardiac function in myocardial ischemia/reperfusion mice.

Wang S, Zhou Y, Luo Y, Kan R, Chen J, Xuan H, Wang C, Chen J, Xu T, Li D
Scientific reports 2021 Jan 21;11(1):2037

---

Oxygenated polycyclic aromatic hydrocarbons from ambient particulate matter induce electrophysiological instability in cardiomyocytes.

Ju S, Lim L, Jiao HY, Choi S, Jun JY, Ki YJ, Choi DH, Lee JY, Song H
Particle and fibre toxicology 2020 Jun 11;17(1):25

---

Astragaloside IV attenuates chronic intermittent hypoxia-induced myocardial injury by modulating Ca(2+) homeostasis.

Jiang S, Jiao G, Chen Y, Han M, Wang X, Liu W
Cell biochemistry and function 2020 Aug;38(6):710-720

---

Atrial fibrillation and its arrhythmogenesis associated with insulin resistance.

Chan YH, Chang GJ, Lai YJ, Chen WJ, Chang SH, Hung LM, Kuo CT, Yeh YH
Cardiovascular diabetology 2019 Sep 26;18(1):125

---

Tachycardia-induced CD44/NOX4 signaling is involved in the development of atrial remodeling.

Chen WJ, Chang SH, Chan YH, Lee JL, Lai YJ, Chang GJ, Tsai FC, Yeh YH
Journal of molecular and cellular cardiology 2019 Oct;135:67-78

---

The harmful effects of acute PM(2.5) exposure to the heart and a novel preventive and therapeutic function of CEOs.

Dong L, Sun W, Li F, Shi M, Meng X, Wang C, Meng M, Tang W, Liu H, Wang L, Song L
Scientific reports 2019 Mar 5;9(1):3495

---

Protective role of heme oxygenase-1 in atrial remodeling.

Yeh YH, Hsu LA, Chen YH, Kuo CT, Chang GJ, Chen WJ
Basic research in cardiology 2016 Sep;111(5):58

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

HeLa cells were subjected to SDS PAGE followed by western blot with 19765-1-AP(RYR2 antibody) at dilution of 1:500

Sample type

cell line

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The Ryanodine Receptor 2 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human Ryanodine Receptor 2. This antibody recognizes human, mouse antigen. The Ryanodine Receptor 2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.

Appendix

19765-1-AP.pdf

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