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- References [16]
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- Product number
- 16163-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#16163-1-AP, RRID:AB_2237805
- Product name
- Presenilin-1-Specific antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Presenilin-1-Specific antibody (Cat. #16163-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Electropositive Citric Acid-Polyethyleneimine Carbon Dots Carrying the PINK1 Gene Regulate ATP-Related Metabolic Dysfunction in APP/PS1-N2a Cells.
Apicidin attenuates memory deficits by reducing the Aβ load in APP/PS1 mice.
Bone Marrow-Derived GCA(+) Immune Cells Drive Alzheimer's Disease Progression.
The epilepsy-associated protein PCDH19 undergoes NMDA receptor-dependent proteolytic cleavage and regulates the expression of immediate-early genes.
Far infrared light irradiation enhances Aβ clearance via increased exocytotic microglial ATP and ameliorates cognitive deficit in Alzheimer's disease-like mice.
Metformin attenuates vascular pathology by increasing expression of insulin-degrading enzyme in a mixed model of cerebral amyloid angiopathy and type 2 diabetes mellitus.
BMP4 overexpression induces the upregulation of APP/Tau and memory deficits in Alzheimer's disease.
Bone marrow mesenchymal stem cells-derived exosomes reduce Aβ deposition and improve cognitive function recovery in mice with Alzheimer's disease by activating sphingosine kinase/sphingosine-1-phosphate signaling pathway.
Direct Activation of Protein Phosphatase 2A (PP2A) by Tricyclic Sulfonamides Ameliorates Alzheimer's Disease Pathogenesis in Cell and Animal Models.
Presenilin1 exerts antiproliferative effects by repressing the Wnt/β-catenin pathway in glioblastoma.
MMP13 inhibition rescues cognitive decline in Alzheimer transgenic mice via BACE1 regulation.
Memantine, a Noncompetitive N-Methyl-D-Aspartate Receptor Antagonist, Attenuates Cerebral Amyloid Angiopathy by Increasing Insulin-Degrading Enzyme Expression.
Liraglutide Ameliorates Hyperhomocysteinemia-Induced Alzheimer-Like Pathology and Memory Deficits in Rats via Multi-molecular Targeting.
CIP2A Causes Tau/APP Phosphorylation, Synaptopathy, and Memory Deficits in Alzheimer's Disease.
Rat embryonic fibroblasts immortalized by MRPS18-2 protein are target for NK-cells.
Maternal gestational betaine supplementation-mediated suppression of hepatic cyclin D2 and presenilin1 gene in newborn piglets is associated with epigenetic regulation of the STAT3-dependent pathway.
Yu S, Guo F, Luo Y, Zhang X, Wang C, Liu Y, Zhang H
Molecules (Basel, Switzerland) 2024 Apr 23;29(9)
Molecules (Basel, Switzerland) 2024 Apr 23;29(9)
Apicidin attenuates memory deficits by reducing the Aβ load in APP/PS1 mice.
Luo B, Chen J, Zhou GF, Xie XY, Tang J, Wen QX, Song L, Xie SQ, Long Y, Chen GJ, Hu XT
CNS neuroscience & therapeutics 2023 May;29(5):1300-1311
CNS neuroscience & therapeutics 2023 May;29(5):1300-1311
Bone Marrow-Derived GCA(+) Immune Cells Drive Alzheimer's Disease Progression.
Zhou R, Wang L, Chen L, Feng X, Zhou R, Xiang P, Wen J, Huang Y, Zhou H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Dec;10(36):e2303402
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Dec;10(36):e2303402
The epilepsy-associated protein PCDH19 undergoes NMDA receptor-dependent proteolytic cleavage and regulates the expression of immediate-early genes.
Gerosa L, Mazzoleni S, Rusconi F, Longaretti A, Lewerissa E, Pelucchi S, Murru L, Giannelli SG, Broccoli V, Marcello E, Kasri NN, Battaglioli E, Passafaro M, Bassani S
Cell reports 2022 May 24;39(8):110857
Cell reports 2022 May 24;39(8):110857
Far infrared light irradiation enhances Aβ clearance via increased exocytotic microglial ATP and ameliorates cognitive deficit in Alzheimer's disease-like mice.
Li Q, Peng J, Luo Y, Zhou J, Li T, Cao L, Peng S, Zuo Z, Wang Z
Journal of neuroinflammation 2022 Jun 14;19(1):145
Journal of neuroinflammation 2022 Jun 14;19(1):145
Metformin attenuates vascular pathology by increasing expression of insulin-degrading enzyme in a mixed model of cerebral amyloid angiopathy and type 2 diabetes mellitus.
Inoue Y, Masuda T, Misumi Y, Ando Y, Ueda M
Neuroscience letters 2021 Sep 25;762:136136
Neuroscience letters 2021 Sep 25;762:136136
BMP4 overexpression induces the upregulation of APP/Tau and memory deficits in Alzheimer's disease.
Zhang X, Li J, Ma L, Xu H, Cao Y, Liang W, Ma J, Wang ZP, Li Y
Cell death discovery 2021 Mar 15;7(1):51
Cell death discovery 2021 Mar 15;7(1):51
Bone marrow mesenchymal stem cells-derived exosomes reduce Aβ deposition and improve cognitive function recovery in mice with Alzheimer's disease by activating sphingosine kinase/sphingosine-1-phosphate signaling pathway.
Wang X, Yang G
Cell biology international 2021 Apr;45(4):775-784
Cell biology international 2021 Apr;45(4):775-784
Direct Activation of Protein Phosphatase 2A (PP2A) by Tricyclic Sulfonamides Ameliorates Alzheimer's Disease Pathogenesis in Cell and Animal Models.
Wei H, Zhang HL, Wang XC, Xie JZ, An DD, Wan L, Wang JZ, Zeng Y, Shu XJ, Westermarck J, Lu YM, Ohlmeyer M, Liu R
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2020 Jul;17(3):1087-1103
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2020 Jul;17(3):1087-1103
Presenilin1 exerts antiproliferative effects by repressing the Wnt/β-catenin pathway in glioblastoma.
Yang W, Wu PF, Ma JX, Liao MJ, Xu LS, Xu MH, Yi L
Cell communication and signaling : CCS 2020 Feb 11;18(1):22
Cell communication and signaling : CCS 2020 Feb 11;18(1):22
MMP13 inhibition rescues cognitive decline in Alzheimer transgenic mice via BACE1 regulation.
Zhu BL, Long Y, Luo W, Yan Z, Lai YJ, Zhao LG, Zhou WH, Wang YJ, Shen LL, Liu L, Deng XJ, Wang XF, Sun F, Chen GJ
Brain : a journal of neurology 2019 Jan 1;142(1):176-192
Brain : a journal of neurology 2019 Jan 1;142(1):176-192
Memantine, a Noncompetitive N-Methyl-D-Aspartate Receptor Antagonist, Attenuates Cerebral Amyloid Angiopathy by Increasing Insulin-Degrading Enzyme Expression.
Inoue Y, Ueda M, Masuda T, Misumi Y, Yamashita T, Ando Y
Molecular neurobiology 2019 Dec;56(12):8573-8588
Molecular neurobiology 2019 Dec;56(12):8573-8588
Liraglutide Ameliorates Hyperhomocysteinemia-Induced Alzheimer-Like Pathology and Memory Deficits in Rats via Multi-molecular Targeting.
Zhang Y, Xie JZ, Xu XY, Hu J, Xu T, Jin S, Yang SJ, Wang JZ
Neuroscience bulletin 2019 Aug;35(4):724-734
Neuroscience bulletin 2019 Aug;35(4):724-734
CIP2A Causes Tau/APP Phosphorylation, Synaptopathy, and Memory Deficits in Alzheimer's Disease.
Shentu YP, Huo Y, Feng XL, Gilbert J, Zhang Q, Liuyang ZY, Wang XL, Wang G, Zhou H, Wang XC, Wang JZ, Lu YM, Westermarck J, Man HY, Liu R
Cell reports 2018 Jul 17;24(3):713-723
Cell reports 2018 Jul 17;24(3):713-723
Rat embryonic fibroblasts immortalized by MRPS18-2 protein are target for NK-cells.
Mushtaq M, Pangigadde PN, Darekar S, Dissen E, Kashuba E
Oncotarget 2017 Sep 12;8(39):64907-64917
Oncotarget 2017 Sep 12;8(39):64907-64917
Maternal gestational betaine supplementation-mediated suppression of hepatic cyclin D2 and presenilin1 gene in newborn piglets is associated with epigenetic regulation of the STAT3-dependent pathway.
Cai D, Yuan M, Jia Y, Liu H, Hu Y, Zhao R
The Journal of nutritional biochemistry 2015 Dec;26(12):1622-31
The Journal of nutritional biochemistry 2015 Dec;26(12):1622-31
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Presenilin-1-Specific antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human Presenilin-1-Specific. This antibody recognizes human,mouse,rat antigen. The Presenilin-1-Specific antibody has been validated for the following applications: ELISA, WB analysis.
