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ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
- References [5]
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- Validations [0]
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- Product number
- ABIN966975 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B) (N-Term,pSer72) antibody
- Antibody type
- Polyclonal
- Antigen
- Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human RRM2B (Ribonucleoside-diphosphate reductase subunit M2B)
- Reactivity
- Human, Mouse
- Vial size
- 0.1mg
Submitted references The full-ORF clone resource of the German cDNA Consortium.
Wild-type p53 regulates human ribonucleotide reductase by protein-protein interaction with p53R2 as well as hRRM2 subunits.
Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells.
p53R2-dependent pathway for DNA synthesis in a p53-regulated cell cycle checkpoint.
A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage.
Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blöcker H, Heubner D, Hoerlein A, Michel G, Wedler H, Köhrer K, Ottenwälder B, Poustka A, Wiemann S, Schupp I
BMC genomics 2007 Oct 31;8:399
BMC genomics 2007 Oct 31;8:399
Wild-type p53 regulates human ribonucleotide reductase by protein-protein interaction with p53R2 as well as hRRM2 subunits.
Xue L, Zhou B, Liu X, Qiu W, Jin Z, Yen Y
Cancer research 2003 Mar 1;63(5):980-6
Cancer research 2003 Mar 1;63(5):980-6
Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells.
Guittet O, Håkansson P, Voevodskaya N, Fridd S, Gräslund A, Arakawa H, Nakamura Y, Thelander L
The Journal of biological chemistry 2001 Nov 2;276(44):40647-51
The Journal of biological chemistry 2001 Nov 2;276(44):40647-51
p53R2-dependent pathway for DNA synthesis in a p53-regulated cell cycle checkpoint.
Yamaguchi T, Matsuda K, Sagiya Y, Iwadate M, Fujino MA, Nakamura Y, Arakawa H
Cancer research 2001 Nov 15;61(22):8256-62
Cancer research 2001 Nov 15;61(22):8256-62
A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage.
Tanaka H, Arakawa H, Yamaguchi T, Shiraishi K, Fukuda S, Matsui K, Takei Y, Nakamura Y
Nature 2000 Mar 2;404(6773):42-9
Nature 2000 Mar 2;404(6773):42-9
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