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Protein structure
BGLAP
Bone gamma-carboxyglutamate proteinOCN
This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015]
Top validated antibodies |
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| R&D Systems |  MAB1419 |
23 references | Monoclonal |
ICC
IHC
FC
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| GeneTex | GTX13418 |
5 references | Monoclonal |
WB
EL
ICC
IHC
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| Novus Biologicals | MAB1419 |
24 references | Monoclonal |
ICC
IHC
FC
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| Proteintech Group | 23418-1-AP |
178 references | Polyclonal |
EL
ICC
IHC
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| Invitrogen Antibodies | PA5-96529 |
1 references | Polyclonal |
WB
EL
ICC
OA
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