Antibody data
- Antibody Data
- Antigen structure
- References [22]
- Comments [0]
- Validations
- Western blot [2]
- Immunohistochemistry [2]
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Validation data
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- Product number
- 12492-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12492-1-AP, RRID:AB_2063531
- Product name
- BMP4 antibody
- Antibody type
- Polyclonal
- Description
- BMP4 antibody (Cat. #12492-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Exercise attenuates high-fat diet-induced PVAT dysfunction through improved inflammatory response and BMP4-regulated adipose tissue browning.
Alpha-lipoic Acid Prevents Bone Loss in Type 2 Diabetes and Postmenopausal Osteoporosis Coexisting Conditions by Modulating the YAP/Glut4 Pathway.
Pectolinarigenin ameliorates osteoporosis via enhancing Wnt signaling cascade in PPARβ-dependent manner.
Directed osteogenic differentiation of human bone marrow mesenchymal stem cells via sustained release of BMP4 from PBVHx-based nanoparticles.
BMP4 Regulates EMT to be Involved in non-Syndromic Cleft lip With or Without Palate.
Ibrutinib Inhibits Angiogenesis and Tumorigenesis in a BTK-Independent Manner.
MiR-145 inhibits the differentiation and proliferation of bone marrow stromal mesenchymal stem cells by GABARAPL1 in steroid-induced femoral head necrosis.
Extracellular vesicles from the inflammatory microenvironment regulate the osteogenic and odontogenic differentiation of periodontal ligament stem cells by miR-758-5p/LMBR1/BMP2/4 axis.
Altered Expression of the Hedgehog Pathway Proteins BMP2, BMP4, SHH, and IHH Involved in Knee Cartilage Damage of Patients With Osteoarthritis and Kashin-Beck Disease.
Plakophilin-2 Promotes Lung Adenocarcinoma Development via Enhancing Focal Adhesion and Epithelial-Mesenchymal Transition.
BMP4 augments the survival of hepatocellular carcinoma (HCC) cells under hypoxia and hypoglycemia conditions by promoting the glycolysis pathway.
ICAM1 initiates CTC cluster formation and trans-endothelial migration in lung metastasis of breast cancer.
Let-7i-5p Regulation of Cell Morphology and Migration Through Distinct Signaling Pathways in Normal and Pathogenic Urethral Fibroblasts.
Single-cell Transcriptome Profiling reveals Dermal and Epithelial cell fate decisions during Embryonic Hair Follicle Development.
SERPINE2 promotes esophageal squamous cell carcinoma metastasis by activating BMP4.
Perinatal exposure to nonylphenol delayed myelination in offspring cerebellum.
Integrative Analysis of Methylome and Transcriptome Reveals the Regulatory Mechanisms of Hair Follicle Morphogenesis in Cashmere Goat.
Human induced pluripotent stem cell-derived mast cells useful for in vitro mast cell activation assay exhibiting phenotypes and morphological characteristics of human mast cells.
Optimization of the chicken chorioallantoic membrane assay as reliable in vivo model for the analysis of osteosarcoma.
Mitochondrial Dynamics Is Critical for the Full Pluripotency and Embryonic Developmental Potential of Pluripotent Stem Cells.
Overexpression of colorectal cancer oncogene CHRDL2 predicts a poor prognosis.
Regulation of Olig2 during astroglial differentiation in the subventricular zone of a cuprizone-induced demyelination mouse model.
Liu X, Jiang X, Hu J, Ding M, Lee SK, Korivi M, Qian Y, Li T, Wang L, Li W
Frontiers in nutrition 2024;11:1393343
Frontiers in nutrition 2024;11:1393343
Alpha-lipoic Acid Prevents Bone Loss in Type 2 Diabetes and Postmenopausal Osteoporosis Coexisting Conditions by Modulating the YAP/Glut4 Pathway.
Xu L, Zhang C, Bao J, Han G, Wang C, Cai Y, Xu G, Sun H, Liu M
Cell biochemistry and biophysics 2024 Jun;82(2):669-685
Cell biochemistry and biophysics 2024 Jun;82(2):669-685
Pectolinarigenin ameliorates osteoporosis via enhancing Wnt signaling cascade in PPARβ-dependent manner.
Qian J, Li Q, Song Y, Gong X, Hu K, Ge G, Sun Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155587
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155587
Directed osteogenic differentiation of human bone marrow mesenchymal stem cells via sustained release of BMP4 from PBVHx-based nanoparticles.
Huang XY, Zhou XX, Yang H, Xu T, Dao JW, Bian L, Wei DX
International journal of biological macromolecules 2024 Apr;265(Pt 1):130649
International journal of biological macromolecules 2024 Apr;265(Pt 1):130649
BMP4 Regulates EMT to be Involved in non-Syndromic Cleft lip With or Without Palate.
Hong JW, Yu Y, Wang LS, Li Z, Zhang R, Wang Q, Ding Z, Zhang JP, Zhang MR, Xu LC
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association 2023 Nov;60(11):1462-1473
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association 2023 Nov;60(11):1462-1473
Ibrutinib Inhibits Angiogenesis and Tumorigenesis in a BTK-Independent Manner.
Liu J, Liu Z, Zhang J, Chen X, Chen J, Sui L, Yu J
Pharmaceutics 2022 Sep 5;14(9)
Pharmaceutics 2022 Sep 5;14(9)
MiR-145 inhibits the differentiation and proliferation of bone marrow stromal mesenchymal stem cells by GABARAPL1 in steroid-induced femoral head necrosis.
Xu P, Chang J, Ma G, Liao F, Xu T, Wu Y, Yin Z
BMC musculoskeletal disorders 2022 Nov 26;23(1):1020
BMC musculoskeletal disorders 2022 Nov 26;23(1):1020
Extracellular vesicles from the inflammatory microenvironment regulate the osteogenic and odontogenic differentiation of periodontal ligament stem cells by miR-758-5p/LMBR1/BMP2/4 axis.
Yan C, Li N, Xiao T, Ye X, Fu L, Ye Y, Xu T, Yu J
Journal of translational medicine 2022 May 13;20(1):208
Journal of translational medicine 2022 May 13;20(1):208
Altered Expression of the Hedgehog Pathway Proteins BMP2, BMP4, SHH, and IHH Involved in Knee Cartilage Damage of Patients With Osteoarthritis and Kashin-Beck Disease.
Deng H, Xiao X, Chilufya MM, Qiao L, Lv Y, Guo Z, Lei J, Liu J, Zhao Y, Zhang J, Wang W, Han J, Qu C
Cartilage 2022 Jan-Mar;13(1):19476035221087706
Cartilage 2022 Jan-Mar;13(1):19476035221087706
Plakophilin-2 Promotes Lung Adenocarcinoma Development via Enhancing Focal Adhesion and Epithelial-Mesenchymal Transition.
Wu Y, Liu L, Shen X, Liu W, Ma R
Cancer management and research 2021;13:559-570
Cancer management and research 2021;13:559-570
BMP4 augments the survival of hepatocellular carcinoma (HCC) cells under hypoxia and hypoglycemia conditions by promoting the glycolysis pathway.
Zhong J, Kang Q, Cao Y, He B, Zhao P, Gou Y, Luo Y, He TC, Fan J
American journal of cancer research 2021;11(3):793-811
American journal of cancer research 2021;11(3):793-811
ICAM1 initiates CTC cluster formation and trans-endothelial migration in lung metastasis of breast cancer.
Taftaf R, Liu X, Singh S, Jia Y, Dashzeveg NK, Hoffmann AD, El-Shennawy L, Ramos EK, Adorno-Cruz V, Schuster EJ, Scholten D, Patel D, Zhang Y, Davis AA, Reduzzi C, Cao Y, D'Amico P, Shen Y, Cristofanilli M, Muller WA, Varadan V, Liu H
Nature communications 2021 Aug 11;12(1):4867
Nature communications 2021 Aug 11;12(1):4867
Let-7i-5p Regulation of Cell Morphology and Migration Through Distinct Signaling Pathways in Normal and Pathogenic Urethral Fibroblasts.
Zhang K, Yang R, Chen J, Qi E, Zhou S, Wang Y, Fu Q, Chen R, Fang X
Frontiers in bioengineering and biotechnology 2020;8:428
Frontiers in bioengineering and biotechnology 2020;8:428
Single-cell Transcriptome Profiling reveals Dermal and Epithelial cell fate decisions during Embryonic Hair Follicle Development.
Ge W, Tan SJ, Wang SH, Li L, Sun XF, Shen W, Wang X
Theranostics 2020;10(17):7581-7598
Theranostics 2020;10(17):7581-7598
SERPINE2 promotes esophageal squamous cell carcinoma metastasis by activating BMP4.
Zhang J, Luo A, Huang F, Gong T, Liu Z
Cancer letters 2020 Jan 28;469:390-398
Cancer letters 2020 Jan 28;469:390-398
Perinatal exposure to nonylphenol delayed myelination in offspring cerebellum.
Jiang Y, You M, Li S, Xu Y, Wang Y
Biochemical pharmacology 2020 Aug;178:114120
Biochemical pharmacology 2020 Aug;178:114120
Integrative Analysis of Methylome and Transcriptome Reveals the Regulatory Mechanisms of Hair Follicle Morphogenesis in Cashmere Goat.
Wang S, Li F, Liu J, Zhang Y, Zheng Y, Ge W, Qu L, Wang X
Cells 2020 Apr 14;9(4)
Cells 2020 Apr 14;9(4)
Human induced pluripotent stem cell-derived mast cells useful for in vitro mast cell activation assay exhibiting phenotypes and morphological characteristics of human mast cells.
Ikuno T, Ito S, Inoue T
The Journal of toxicological sciences 2019;44(11):789-797
The Journal of toxicological sciences 2019;44(11):789-797
Optimization of the chicken chorioallantoic membrane assay as reliable in vivo model for the analysis of osteosarcoma.
Kunz P, Schenker A, Sähr H, Lehner B, Fellenberg J
PloS one 2019;14(4):e0215312
PloS one 2019;14(4):e0215312
Mitochondrial Dynamics Is Critical for the Full Pluripotency and Embryonic Developmental Potential of Pluripotent Stem Cells.
Zhong X, Cui P, Cai Y, Wang L, He X, Long P, Lu K, Yan R, Zhang Y, Pan X, Zhao X, Li W, Zhang H, Zhou Q, Gao P
Cell metabolism 2019 Apr 2;29(4):979-992.e4
Cell metabolism 2019 Apr 2;29(4):979-992.e4
Overexpression of colorectal cancer oncogene CHRDL2 predicts a poor prognosis.
Sun J, Liu X, Gao H, Zhang L, Ji Q, Wang Z, Zhou L, Wang Y, Sui H, Fan Z, Li Q
Oncotarget 2017 Feb 14;8(7):11489-11506
Oncotarget 2017 Feb 14;8(7):11489-11506
Regulation of Olig2 during astroglial differentiation in the subventricular zone of a cuprizone-induced demyelination mouse model.
Chen LP, Li ZF, Ping M, Li R, Liu J, Xie XH, Song XJ, Guo L
Neuroscience 2012 Sep 27;221:96-107
Neuroscience 2012 Sep 27;221:96-107
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse heart tissue were subjected to SDS PAGE followed by western blot with 12492-1-AP( BMP4 Antibody) at dilution of 1:300
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- rat heart tissue were subjected to SDS PAGE followed by western blot with 12492-1-AP( BMP4 Antibody) at dilution of 1:600
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human lung using 12492-1-AP(BMP4 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The BMP4 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human BMP4. This antibody recognizes human,mouse,rat antigen. The BMP4 antibody has been validated for the following applications: ELISA, IHC, WB analysis.