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- Antibody Data
- Antigen structure
- References [33]
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- Western blot [2]
- Immunohistochemistry [2]
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- Product number
- 12492-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12492-1-AP, RRID:AB_2063531
- Product name
- BMP4 antibody
- Antibody type
- Polyclonal
- Description
- BMP4 antibody (Cat. #12492-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Astragalus membranaceus Polysaccharides Attenuate Osteoarthritis in Human Primary Chondrocytes and in Animal Model: Mechanism Study Using RNA-Seq and Network Pharmacology.
Dose-optimized HILT promotes peripheral nerve repair through BMP4-Smad9-mediated inhibition of neuroinflammation and oxidative stress.
Downregulation of MLL1 Promotes Intestinal Epithelial Barrier Repair Through Gata4/Bmp4 Activation to Ameliorate Crohn's Disease-Like Colitis in Mice.
Sr²⁺-coordinated asiatic acid/silk fibroin hybrid hydrogels for enhanced osteogenesis and antibacterial therapy in infective bone defects.
Electroacupuncture alleviates pain by activating the MD2/TLR4/NF-κB pathway in the ST36 acupoint.
Single-cell and spatial RNA sequencing identify divergent microenvironments and progression signatures in early- versus late-onset prostate cancer.
KIF26B promotes bladder cancer progression via activating Wnt/β-catenin signaling in a TRAF2-dependent pathway.
Strychni Semen and its active compounds promote axon regeneration following peripheral nerve injury by suppressing myeloperoxidase in the dorsal root ganglia.
Exercise attenuates high-fat diet-induced PVAT dysfunction through improved inflammatory response and BMP4-regulated adipose tissue browning.
A tantalum-containing zirconium-based metallic glass with superior endosseous implant relevant properties.
Alpha-lipoic Acid Prevents Bone Loss in Type 2 Diabetes and Postmenopausal Osteoporosis Coexisting Conditions by Modulating the YAP/Glut4 Pathway.
Stepwise dual-release microparticles of BMP-4 and SCF in induced pluripotent stem cell spheroids enhance differentiation into hematopoietic stem cells.
Pectolinarigenin ameliorates osteoporosis via enhancing Wnt signaling cascade in PPARβ-dependent manner.
NIR Laser Irradiation Promotes Osteogenic Differentiation of PDLSCs Through the Activation of TRPV1 Channels and Subsequent Calcium Signaling.
Directed osteogenic differentiation of human bone marrow mesenchymal stem cells via sustained release of BMP4 from PBVHx-based nanoparticles.
BMP4 Regulates EMT to be Involved in non-Syndromic Cleft lip With or Without Palate.
Ibrutinib Inhibits Angiogenesis and Tumorigenesis in a BTK-Independent Manner.
MiR-145 inhibits the differentiation and proliferation of bone marrow stromal mesenchymal stem cells by GABARAPL1 in steroid-induced femoral head necrosis.
Extracellular vesicles from the inflammatory microenvironment regulate the osteogenic and odontogenic differentiation of periodontal ligament stem cells by miR-758-5p/LMBR1/BMP2/4 axis.
Altered Expression of the Hedgehog Pathway Proteins BMP2, BMP4, SHH, and IHH Involved in Knee Cartilage Damage of Patients With Osteoarthritis and Kashin-Beck Disease.
Plakophilin-2 Promotes Lung Adenocarcinoma Development via Enhancing Focal Adhesion and Epithelial-Mesenchymal Transition.
BMP4 augments the survival of hepatocellular carcinoma (HCC) cells under hypoxia and hypoglycemia conditions by promoting the glycolysis pathway.
ICAM1 initiates CTC cluster formation and trans-endothelial migration in lung metastasis of breast cancer.
Let-7i-5p Regulation of Cell Morphology and Migration Through Distinct Signaling Pathways in Normal and Pathogenic Urethral Fibroblasts.
Single-cell Transcriptome Profiling reveals Dermal and Epithelial cell fate decisions during Embryonic Hair Follicle Development.
SERPINE2 promotes esophageal squamous cell carcinoma metastasis by activating BMP4.
Perinatal exposure to nonylphenol delayed myelination in offspring cerebellum.
Integrative Analysis of Methylome and Transcriptome Reveals the Regulatory Mechanisms of Hair Follicle Morphogenesis in Cashmere Goat.
Human induced pluripotent stem cell-derived mast cells useful for in vitro mast cell activation assay exhibiting phenotypes and morphological characteristics of human mast cells.
Optimization of the chicken chorioallantoic membrane assay as reliable in vivo model for the analysis of osteosarcoma.
Mitochondrial Dynamics Is Critical for the Full Pluripotency and Embryonic Developmental Potential of Pluripotent Stem Cells.
Overexpression of colorectal cancer oncogene CHRDL2 predicts a poor prognosis.
Regulation of Olig2 during astroglial differentiation in the subventricular zone of a cuprizone-induced demyelination mouse model.
Xu H, Li Y, Wang J, Xin Y, Xu Q, Qin X, Yang X, Yan Y, Chen Q, Chen Y, Zhang Y, Lu C, Xu K, Wang X
Phytotherapy research : PTR 2026 May;40(5):2249-2269
Phytotherapy research : PTR 2026 May;40(5):2249-2269
Dose-optimized HILT promotes peripheral nerve repair through BMP4-Smad9-mediated inhibition of neuroinflammation and oxidative stress.
Gong L, Li D, Zhao X, Qu Y, Song S, Liu J, Yue S
APL bioengineering 2026 Mar;10(1):016115
APL bioengineering 2026 Mar;10(1):016115
Downregulation of MLL1 Promotes Intestinal Epithelial Barrier Repair Through Gata4/Bmp4 Activation to Ameliorate Crohn's Disease-Like Colitis in Mice.
Song X, Li J, Chen Y, Li B, Yang Y, Guan X, Zhang X, Tao L, Geng Z, Zuo L, Wang Y, Wang L, Hu J
Cell proliferation 2026 Feb 24;:e70182
Cell proliferation 2026 Feb 24;:e70182
Sr²⁺-coordinated asiatic acid/silk fibroin hybrid hydrogels for enhanced osteogenesis and antibacterial therapy in infective bone defects.
Qin HJ, He SY, Zhao SB, Xiao TH, Cui FT, Zhang LY, Chen GY, Chen JY, Dai DM, Liu XY, Hu XJ
Colloids and surfaces. B, Biointerfaces 2026 Apr 7;265:115690
Colloids and surfaces. B, Biointerfaces 2026 Apr 7;265:115690
Electroacupuncture alleviates pain by activating the MD2/TLR4/NF-κB pathway in the ST36 acupoint.
Fu J, Cheng G, Lyu Z, Fan Z, Li F, Xu Z, Chen B, Guo Y, Liu Y, Zhang H, Xu Y, Guo Y
Frontiers in immunology 2025;16:1626755
Frontiers in immunology 2025;16:1626755
Single-cell and spatial RNA sequencing identify divergent microenvironments and progression signatures in early- versus late-onset prostate cancer.
Cheng Y, Liu B, Xin J, Wu X, Li W, Shang J, Wu J, Zhang Z, Xu B, Du M, Cheng G, Wang M
Nature aging 2025 May;5(5):909-928
Nature aging 2025 May;5(5):909-928
KIF26B promotes bladder cancer progression via activating Wnt/β-catenin signaling in a TRAF2-dependent pathway.
Wang JM, Zhang FH, Xie HY, Liu ZX, Tang YJ, Shu X, Wu YQ, Lu DH, Sun JZ, Ying YF, Ma XY, Zheng XY, Wang X, Liu B, Li JF, Xie LP, Luo JD
Cell reports 2025 May 27;44(5):115595
Cell reports 2025 May 27;44(5):115595
Strychni Semen and its active compounds promote axon regeneration following peripheral nerve injury by suppressing myeloperoxidase in the dorsal root ganglia.
Zhang Y, Zhao XY, Liu MT, Zhou ZC, Cheng HB, Jiang XH, Zheng YR, Chen Z
Journal of integrative medicine 2025 Mar;23(2):169-181
Journal of integrative medicine 2025 Mar;23(2):169-181
Exercise attenuates high-fat diet-induced PVAT dysfunction through improved inflammatory response and BMP4-regulated adipose tissue browning.
Liu X, Jiang X, Hu J, Ding M, Lee SK, Korivi M, Qian Y, Li T, Wang L, Li W
Frontiers in nutrition 2024;11:1393343
Frontiers in nutrition 2024;11:1393343
A tantalum-containing zirconium-based metallic glass with superior endosseous implant relevant properties.
Wu Y, Wang F, Huang Y, Zheng F, Zeng Y, Lu Z, Wang S, Sun B, Sun Y
Bioactive materials 2024 Sep;39:25-40
Bioactive materials 2024 Sep;39:25-40
Alpha-lipoic Acid Prevents Bone Loss in Type 2 Diabetes and Postmenopausal Osteoporosis Coexisting Conditions by Modulating the YAP/Glut4 Pathway.
Xu L, Zhang C, Bao J, Han G, Wang C, Cai Y, Xu G, Sun H, Liu M
Cell biochemistry and biophysics 2024 Jun;82(2):669-685
Cell biochemistry and biophysics 2024 Jun;82(2):669-685
Stepwise dual-release microparticles of BMP-4 and SCF in induced pluripotent stem cell spheroids enhance differentiation into hematopoietic stem cells.
Bello AB, Canlas KKV, Kim D, Park H, Lee SH
Journal of controlled release : official journal of the Controlled Release Society 2024 Jul;371:386-405
Journal of controlled release : official journal of the Controlled Release Society 2024 Jul;371:386-405
Pectolinarigenin ameliorates osteoporosis via enhancing Wnt signaling cascade in PPARβ-dependent manner.
Qian J, Li Q, Song Y, Gong X, Hu K, Ge G, Sun Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155587
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155587
NIR Laser Irradiation Promotes Osteogenic Differentiation of PDLSCs Through the Activation of TRPV1 Channels and Subsequent Calcium Signaling.
Zeng JH, Ma B, Shen XQ, Geng YM
Photobiomodulation, photomedicine, and laser surgery 2024 Dec;42(12):747-753
Photobiomodulation, photomedicine, and laser surgery 2024 Dec;42(12):747-753
Directed osteogenic differentiation of human bone marrow mesenchymal stem cells via sustained release of BMP4 from PBVHx-based nanoparticles.
Huang XY, Zhou XX, Yang H, Xu T, Dao JW, Bian L, Wei DX
International journal of biological macromolecules 2024 Apr;265(Pt 1):130649
International journal of biological macromolecules 2024 Apr;265(Pt 1):130649
BMP4 Regulates EMT to be Involved in non-Syndromic Cleft lip With or Without Palate.
Hong JW, Yu Y, Wang LS, Li Z, Zhang R, Wang Q, Ding Z, Zhang JP, Zhang MR, Xu LC
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association 2023 Nov;60(11):1462-1473
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association 2023 Nov;60(11):1462-1473
Ibrutinib Inhibits Angiogenesis and Tumorigenesis in a BTK-Independent Manner.
Liu J, Liu Z, Zhang J, Chen X, Chen J, Sui L, Yu J
Pharmaceutics 2022 Sep 5;14(9)
Pharmaceutics 2022 Sep 5;14(9)
MiR-145 inhibits the differentiation and proliferation of bone marrow stromal mesenchymal stem cells by GABARAPL1 in steroid-induced femoral head necrosis.
Xu P, Chang J, Ma G, Liao F, Xu T, Wu Y, Yin Z
BMC musculoskeletal disorders 2022 Nov 26;23(1):1020
BMC musculoskeletal disorders 2022 Nov 26;23(1):1020
Extracellular vesicles from the inflammatory microenvironment regulate the osteogenic and odontogenic differentiation of periodontal ligament stem cells by miR-758-5p/LMBR1/BMP2/4 axis.
Yan C, Li N, Xiao T, Ye X, Fu L, Ye Y, Xu T, Yu J
Journal of translational medicine 2022 May 13;20(1):208
Journal of translational medicine 2022 May 13;20(1):208
Altered Expression of the Hedgehog Pathway Proteins BMP2, BMP4, SHH, and IHH Involved in Knee Cartilage Damage of Patients With Osteoarthritis and Kashin-Beck Disease.
Deng H, Xiao X, Chilufya MM, Qiao L, Lv Y, Guo Z, Lei J, Liu J, Zhao Y, Zhang J, Wang W, Han J, Qu C
Cartilage 2022 Jan-Mar;13(1):19476035221087706
Cartilage 2022 Jan-Mar;13(1):19476035221087706
Plakophilin-2 Promotes Lung Adenocarcinoma Development via Enhancing Focal Adhesion and Epithelial-Mesenchymal Transition.
Wu Y, Liu L, Shen X, Liu W, Ma R
Cancer management and research 2021;13:559-570
Cancer management and research 2021;13:559-570
BMP4 augments the survival of hepatocellular carcinoma (HCC) cells under hypoxia and hypoglycemia conditions by promoting the glycolysis pathway.
Zhong J, Kang Q, Cao Y, He B, Zhao P, Gou Y, Luo Y, He TC, Fan J
American journal of cancer research 2021;11(3):793-811
American journal of cancer research 2021;11(3):793-811
ICAM1 initiates CTC cluster formation and trans-endothelial migration in lung metastasis of breast cancer.
Taftaf R, Liu X, Singh S, Jia Y, Dashzeveg NK, Hoffmann AD, El-Shennawy L, Ramos EK, Adorno-Cruz V, Schuster EJ, Scholten D, Patel D, Zhang Y, Davis AA, Reduzzi C, Cao Y, D'Amico P, Shen Y, Cristofanilli M, Muller WA, Varadan V, Liu H
Nature communications 2021 Aug 11;12(1):4867
Nature communications 2021 Aug 11;12(1):4867
Let-7i-5p Regulation of Cell Morphology and Migration Through Distinct Signaling Pathways in Normal and Pathogenic Urethral Fibroblasts.
Zhang K, Yang R, Chen J, Qi E, Zhou S, Wang Y, Fu Q, Chen R, Fang X
Frontiers in bioengineering and biotechnology 2020;8:428
Frontiers in bioengineering and biotechnology 2020;8:428
Single-cell Transcriptome Profiling reveals Dermal and Epithelial cell fate decisions during Embryonic Hair Follicle Development.
Ge W, Tan SJ, Wang SH, Li L, Sun XF, Shen W, Wang X
Theranostics 2020;10(17):7581-7598
Theranostics 2020;10(17):7581-7598
SERPINE2 promotes esophageal squamous cell carcinoma metastasis by activating BMP4.
Zhang J, Luo A, Huang F, Gong T, Liu Z
Cancer letters 2020 Jan 28;469:390-398
Cancer letters 2020 Jan 28;469:390-398
Perinatal exposure to nonylphenol delayed myelination in offspring cerebellum.
Jiang Y, You M, Li S, Xu Y, Wang Y
Biochemical pharmacology 2020 Aug;178:114120
Biochemical pharmacology 2020 Aug;178:114120
Integrative Analysis of Methylome and Transcriptome Reveals the Regulatory Mechanisms of Hair Follicle Morphogenesis in Cashmere Goat.
Wang S, Li F, Liu J, Zhang Y, Zheng Y, Ge W, Qu L, Wang X
Cells 2020 Apr 14;9(4)
Cells 2020 Apr 14;9(4)
Human induced pluripotent stem cell-derived mast cells useful for in vitro mast cell activation assay exhibiting phenotypes and morphological characteristics of human mast cells.
Ikuno T, Ito S, Inoue T
The Journal of toxicological sciences 2019;44(11):789-797
The Journal of toxicological sciences 2019;44(11):789-797
Optimization of the chicken chorioallantoic membrane assay as reliable in vivo model for the analysis of osteosarcoma.
Kunz P, Schenker A, Sähr H, Lehner B, Fellenberg J
PloS one 2019;14(4):e0215312
PloS one 2019;14(4):e0215312
Mitochondrial Dynamics Is Critical for the Full Pluripotency and Embryonic Developmental Potential of Pluripotent Stem Cells.
Zhong X, Cui P, Cai Y, Wang L, He X, Long P, Lu K, Yan R, Zhang Y, Pan X, Zhao X, Li W, Zhang H, Zhou Q, Gao P
Cell metabolism 2019 Apr 2;29(4):979-992.e4
Cell metabolism 2019 Apr 2;29(4):979-992.e4
Overexpression of colorectal cancer oncogene CHRDL2 predicts a poor prognosis.
Sun J, Liu X, Gao H, Zhang L, Ji Q, Wang Z, Zhou L, Wang Y, Sui H, Fan Z, Li Q
Oncotarget 2017 Feb 14;8(7):11489-11506
Oncotarget 2017 Feb 14;8(7):11489-11506
Regulation of Olig2 during astroglial differentiation in the subventricular zone of a cuprizone-induced demyelination mouse model.
Chen LP, Li ZF, Ping M, Li R, Liu J, Xie XH, Song XJ, Guo L
Neuroscience 2012 Sep 27;221:96-107
Neuroscience 2012 Sep 27;221:96-107
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse heart tissue were subjected to SDS PAGE followed by western blot with 12492-1-AP( BMP4 Antibody) at dilution of 1:300
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- rat heart tissue were subjected to SDS PAGE followed by western blot with 12492-1-AP( BMP4 Antibody) at dilution of 1:600
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human lung using 12492-1-AP(BMP4 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The BMP4 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human BMP4. This antibody recognizes human,mouse,rat antigen. The BMP4 antibody has been validated for the following applications: ELISA, IHC, WB analysis.
