13011-1-AP

antibody from Proteintech Group

Targeting: ETV5 ERM

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Antibody Data

Product number

13011-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#13011-1-AP, RRID:AB_2278092

Product name

ETV5 antibody

Antibody type

Polyclonal

Description

KD/KO validated ETV5 antibody (Cat. #13011-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

ETV5 improves ischemic stroke by targeting HACE1/Nrf2 axis to inhibit microglia M1 polarization and neuron pyroptosis.

Meng D, Su Q, Jia K, Jin M, Liu W, Yang S, Su Z
Biochemical pharmacology 2025 Oct;240:117057

---

Pyroptosis inhibition alleviates acute lung injury via E-twenty-six variant gene 5-mediated downregulation of gasdermin D.

Zhang W, Wang X, Ma C, Liang B, Ma L, Wang Y, Lin Y, Han S
Respiratory physiology & neurobiology 2025 Jan;331:104346

---

The repressor Capicua is a barrier to lung tumor development driven by Kras/Trp53 mutations.

Ballesteros-González I, Hernández-Navas I, Brehey O, Lechuga CG, Salmón M, Scotece M, Velasco-Vicente R, Flores-Gómez AA, Cebriá A, Simón-Carrasco L, Jiménez G, Musteanu M, Guerra C, Domínguez O, Caleiras E, Blanco-Aparicio C, Pons T, Ferrer I, Paz-Ares L, Torres-Ruiz R, Rodríguez-Perales S, Barbacid M, Drosten M
EMBO molecular medicine 2025 Dec;17(12):3377-3406

---

FGF-induced phospholipase Cγ signaling regulates lacrimal gland branching by competing with PI3K in phosphoinositide metabolism.

Wang Q, Tao C, Wu Y, Anderson KE, Makrides N, Hannan A, Peregrin J, Lin CS, Ding Z, Li W, Hawkins P, Stephens L, Zhang X
Cell reports 2025 Aug 26;44(8):116046

---

Identification of ETV5 as a prognostic marker related to epigenetic modification in pan-cancer and facilitates tumor progression in hepatocellular carcinoma.

Su H, Zhao L, Fang T, Han W, Fan H
Scientific reports 2024 Nov 29;14(1):29695

---

ETV5 facilitates tumor progression in head-neck squamous cell carcinoma.

Yu S, Ma Z, Chen T, Wang H, Yao Q, Li J, Cheng J
Oral diseases 2024 May;30(4):2004-2017

---

ERK signaling expands mammalian cortical radial glial cells and extends the neurogenic period.

Sun M, Gao Y, Li Z, Yang L, Liu G, Xu Z, Guo R, You Y, Yang Z
Proceedings of the National Academy of Sciences of the United States of America 2024 Mar 26;121(13):e2314802121

---

Microglial lipid droplet accumulation in tauopathy brain is regulated by neuronal AMPK.

Li Y, Munoz-Mayorga D, Nie Y, Kang N, Tao Y, Lagerwall J, Pernaci C, Curtin G, Coufal NG, Mertens J, Shi L, Chen X
Cell metabolism 2024 Jun 4;36(6):1351-1370.e8

---

FGF signaling modulates mechanotransduction/WNT signaling in progenitors during tooth root development.

Pei F, Guo T, Zhang M, Ma L, Jing J, Feng J, Ho TV, Wen Q, Chai Y
Bone research 2024 Jun 24;12(1):37

---

DDX20 is required for cell-cycle reentry of prospermatogonia and establishment of spermatogonial stem cell pool during testicular development in mice.

Zou D, Li K, Su L, Liu J, Lu Y, Huang R, Li M, Mang X, Geng Q, Li P, Tang J, Yu Z, Zhang Z, Chen D, Miao S, Yu J, Yan W, Song W
Developmental cell 2024 Jul 8;59(13):1707-1723.e8

---

ETV4 and ETV5 Orchestrate FGF-Mediated Lineage Specification and Epiblast Maturation during Early Mouse Development.

Simon CS, Garg V, Kuo YY, Niakan KK, Hadjantonakis AK
bioRxiv : the preprint server for biology 2024 Jul 24;

---

"Osteo-Organogenesis Niche" Hyaluronic Acid Engineered Materials Directing Re-Osteo-Organogenesis via Manipulating Macrophage CD44-MAPK/ERK-ETV1/5-MRC1 Axis.

Han Z, Lin Y, Guo X, Xu J, Gao X, Yang R, Zhao Y, Gui M, Zhang L, Guo Y, Chen Z
Advanced healthcare materials 2024 Dec;13(32):e2403122

---

Optimized lentiviral vector transduction of adherent cells and analysis in sulforhodamine B proliferation and chromatin immunoprecipitation assays.

Li L, Trent JC, Eid JE
STAR protocols 2023 Mar 17;4(1):102109

---

Isthmin-1 (Ism1) modulates renal branching morphogenesis and mesenchyme condensation during early kidney development.

Gao G, Li X, Jiang Z, Osorio L, Tang YL, Yu X, Jin G, Zhou Z
Nature communications 2023 Apr 25;14(1):2378

---

A small secreted protein NICOL regulates lumicrine-mediated sperm maturation and male fertility.

Kiyozumi D, Shimada K, Chalick M, Emori C, Kodani M, Oura S, Noda T, Endo T, Matzuk MM, Wreschner DH, Ikawa M
Nature communications 2023 Apr 24;14(1):2354

---

Inhibition of MAPK/ERK pathway activation rescues congenital anomalies of the kidney and urinary tract (CAKUT) in Robo2(PB/+) Gen1(PB/+) mice.

Du X, Yu M, Ju H, Xue S, Li Y, Wu X, Xu H, Shen Q
Biochemical and biophysical research communications 2023 Apr 23;653:153-160

---

ERK phosphorylation disrupts the intramolecular interaction of capicua to promote cytoplasmic translocation of capicua and tumor growth.

Park J, Park GY, Lee J, Park J, Kim S, Kim E, Park SY, Yoon JH, Lee Y
Frontiers in molecular biosciences 2022;9:1030725

---

The dynamic, combinatorial cis-regulatory lexicon of epidermal differentiation.

Kim DS, Risca VI, Reynolds DL, Chappell J, Rubin AJ, Jung N, Donohue LKH, Lopez-Pajares V, Kathiria A, Shi M, Zhao Z, Deep H, Sharmin M, Rao D, Lin S, Chang HY, Snyder MP, Greenleaf WJ, Kundaje A, Khavari PA
Nature genetics 2021 Nov;53(11):1564-1576

---

MAPK pathway activation selectively inhibits ASCL1-driven small cell lung cancer.

Caeser R, Hulton C, Costa E, Durani V, Little M, Chen X, Tischfield SE, Asher M, Kombak FE, Chavan SS, Shah NS, Ciampricotti M, de Stanchina E, Poirier JT, Rudin CM, Sen T
iScience 2021 Nov 19;24(11):103224

---

Long noncoding RNA LINC00284 facilitates cell proliferation in papillary thyroid cancer via impairing miR-3127-5p targeted E2F7 suppression.

Zhou B, Ge Y, Shao Q, Yang L, Chen X, Jiang G
Cell death discovery 2021 Jun 26;7(1):156

---

ETV5 Regulates Hepatic Fatty Acid Metabolism Through PPAR Signaling Pathway.

Mao Z, Feng M, Li Z, Zhou M, Xu L, Pan K, Wang S, Su W, Zhang W
Diabetes 2021 Jan;70(1):214-226

---

ETS variant transcription factor 5 and c-Myc cooperate in derepressing the human telomerase gene promoter via composite ETS/E-box motifs.

Zhang F, Wang S, Zhu J
The Journal of biological chemistry 2020 Jul 17;295(29):10062-10075

---

Capicua restricts cancer stem cell-like properties in breast cancer cells.

Yoe J, Kim D, Kim S, Lee Y
Oncogene 2020 Apr;39(17):3489-3506

---

Biological and RNA regulatory function of MOV10 in mammalian germ cells.

Fu K, Tian S, Tan H, Wang C, Wang H, Wang M, Wang Y, Chen Z, Wang Y, Yue Q, Xu Q, Zhang S, Li H, Xie J, Lin M, Luo M, Chen F, Ye L, Zheng K
BMC biology 2019 May 14;17(1):39

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Capicua regulates neural stem cell proliferation and lineage specification through control of Ets factors.

Ahmad ST, Rogers AD, Chen MJ, Dixit R, Adnani L, Frankiw LS, Lawn SO, Blough MD, Alshehri M, Wu W, Marra MA, Robbins SM, Cairncross JG, Schuurmans C, Chan JA
Nature communications 2019 May 1;10(1):2000

---

FAT4 Fine-Tunes Kidney Development by Regulating RET Signaling.

Zhang H, Bagherie-Lachidan M, Badouel C, Enderle L, Peidis P, Bremner R, Kuure S, Jain S, McNeill H
Developmental cell 2019 Mar 25;48(6):780-792.e4

---

Interaction of BRAF-induced ETS factors with mutant TERT promoter in papillary thyroid cancer.

Song YS, Yoo SK, Kim HH, Jung G, Oh AR, Cha JY, Kim SJ, Cho SW, Lee KE, Seo JS, Park YJ
Endocrine-related cancer 2019 Jun;26(6):629-641

---

Regulation of the ERK signalling pathway in the developing mouse blastocyst.

Azami T, Bassalert C, Allègre N, Valverde Estrella L, Pouchin P, Ema M, Chazaud C
Development (Cambridge, England) 2019 Jul 25;146(14)

---

Loss of Ataxin-1 Potentiates Alzheimer's Pathogenesis by Elevating Cerebral BACE1 Transcription.

Suh J, Romano DM, Nitschke L, Herrick SP, DiMarzio BA, Dzhala V, Bae JS, Oram MK, Zheng Y, Hooli B, Mullin K, Gennarino VA, Wasco W, Schmahmann JD, Albers MW, Zoghbi HY, Tanzi RE
Cell 2019 Aug 22;178(5):1159-1175.e17

---

ETV5 regulates GOAT/ghrelin system in an mTORC1-dependent manner.

Mao Z, Yang Q, Yin W, Su W, Lin H, Feng M, Pan K, Yin Y, Zhang W
Molecular and cellular endocrinology 2019 Apr 5;485:72-80

---

Transcription factor Etv5 is essential for the maintenance of alveolar type II cells.

Zhang Z, Newton K, Kummerfeld SK, Webster J, Kirkpatrick DS, Phu L, Eastham-Anderson J, Liu J, Lee WP, Wu J, Li H, Junttila MR, Dixit VM
Proceedings of the National Academy of Sciences of the United States of America 2017 Apr 11;114(15):3903-3908

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Ret and Etv4 Promote Directed Movements of Progenitor Cells during Renal Branching Morphogenesis.

Riccio P, Cebrian C, Zong H, Hippenmeyer S, Costantini F
PLoS biology 2016 Feb;14(2):e1002382

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A critical role for NF2 and the Hippo pathway in branching morphogenesis.

Reginensi A, Enderle L, Gregorieff A, Johnson RL, Wrana JL, McNeill H
Nature communications 2016 Aug 2;7:12309

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The ETV5 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human ETV5. This antibody recognizes human,mouse,rat antigen. The ETV5 antibody has been validated for the following applications: ELISA, WB analysis.

Appendix

13011-1-AP.pdf

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