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- Product number
- 20217-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#20217-1-AP, RRID:AB_10805766
- Product name
- SLIT2-Specific antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SLIT2-Specific antibody (Cat. #20217-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references A blood-brain barrier- and blood-brain tumor barrier-penetrating siRNA delivery system targeting gliomas for brain tumor immunotherapy.
CCN2/CTGF promotes liver fibrosis through crosstalk with the Slit2/Robo signaling.
An integrated single cell and spatial transcriptomic map of human white adipose tissue.
PIEZO2 promotes cell proliferation and metastasis in colon carcinoma through the SLIT2/ROBO1/VEGFC pathway.
Cancer associated fibroblast derived SLIT2 drives gastric cancer cell metastasis by activating NEK9.
RNA m6A reader IGF2BP3 promotes metastasis of triple-negative breast cancer via SLIT2 repression.
Synaptogenic activity of the axon guidance molecule Robo2 underlies hippocampal circuit function.
Mechanistic Targets of Diallyl Trisulfide in Human Breast Cancer Cells Identified by RNA-seq Analysis.
Role of Slit2 upregulation in recurrent miscarriage through regulation of stromal decidualization.
Crosstalk between the activated Slit2-Robo1 pathway and TGF-β1 signalling promotes cardiac fibrosis.
Deletion of Mea6 in Cerebellar Granule Cells Impairs Synaptic Development and Motor Performance.
Depression-/Anxiety-Like Behavior Alterations in Adult Slit2 Transgenic Mice.
Tumoural activation of TLR3-SLIT2 axis in endothelium drives metastasis.
Inhibition of miR-200b-3p alleviates hypoxia-ischemic brain damage via targeting Slit2 in neonatal rats.
Identification and validation of smoking-related genes in lung adenocarcinoma using an in vitro carcinogenesis model and bioinformatics analysis.
MEA6 Deficiency Impairs Cerebellar Development and Motor Performance by Tethering Protein Trafficking.
Slit2/Robo1 signaling is involved in angiogenesis of glomerular endothelial cells exposed to a diabetic-like environment.
Alterted SLIT2/ROBO1 signalling is linked to impaired placentation of missed and threatened miscarriage in early pregnancy.
Dendrite self-avoidance requires cell-autonomous slit/robo signaling in cerebellar purkinje cells.
Tang L, Zhang R, Wang Y, Liu M, Hu D, Wang Y, Yang L
Journal of controlled release : official journal of the Controlled Release Society 2024 May;369:642-657
Journal of controlled release : official journal of the Controlled Release Society 2024 May;369:642-657
CCN2/CTGF promotes liver fibrosis through crosstalk with the Slit2/Robo signaling.
Pi L, Sun C, Jn-Simon N, Basha S, Thomas H, Figueroa V, Zarrinpar A, Cao Q, Petersen B
Journal of cell communication and signaling 2023 Mar;17(1):137-150
Journal of cell communication and signaling 2023 Mar;17(1):137-150
An integrated single cell and spatial transcriptomic map of human white adipose tissue.
Massier L, Jalkanen J, Elmastas M, Zhong J, Wang T, Nono Nankam PA, Frendo-Cumbo S, Bäckdahl J, Subramanian N, Sekine T, Kerr AG, Tseng BTP, Laurencikiene J, Buggert M, Lourda M, Kublickiene K, Bhalla N, Andersson A, Valsesia A, Astrup A, Blaak EE, Ståhl PL, Viguerie N, Langin D, Wolfrum C, Blüher M, Rydén M, Mejhert N
Nature communications 2023 Mar 15;14(1):1438
Nature communications 2023 Mar 15;14(1):1438
PIEZO2 promotes cell proliferation and metastasis in colon carcinoma through the SLIT2/ROBO1/VEGFC pathway.
Shang H, Xu A, Yan H, Xu D, Zhang J, Fang X
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2023 Jul;32(7):763-776
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2023 Jul;32(7):763-776
Cancer associated fibroblast derived SLIT2 drives gastric cancer cell metastasis by activating NEK9.
Lu G, Du R, Dong J, Sun Y, Zhou F, Feng F, Feng B, Han Y, Shang Y
Cell death & disease 2023 Jul 13;14(7):421
Cell death & disease 2023 Jul 13;14(7):421
RNA m6A reader IGF2BP3 promotes metastasis of triple-negative breast cancer via SLIT2 repression.
Jiang T, He X, Zhao Z, Zhang X, Wang T, Jia L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Nov;36(11):e22618
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Nov;36(11):e22618
Synaptogenic activity of the axon guidance molecule Robo2 underlies hippocampal circuit function.
Blockus H, Rolotti SV, Szoboszlay M, Peze-Heidsieck E, Ming T, Schroeder A, Apostolo N, Vennekens KM, Katsamba PS, Bahna F, Mannepalli S, Ahlsen G, Honig B, Shapiro L, de Wit J, Losonczy A, Polleux F
Cell reports 2021 Oct 19;37(3):109828
Cell reports 2021 Oct 19;37(3):109828
Mechanistic Targets of Diallyl Trisulfide in Human Breast Cancer Cells Identified by RNA-seq Analysis.
Hahm ER, Kim SH, Mathan SV, Singh RP, Singh SV
Journal of cancer prevention 2021 Jun 30;26(2):128-136
Journal of cancer prevention 2021 Jun 30;26(2):128-136
Role of Slit2 upregulation in recurrent miscarriage through regulation of stromal decidualization.
Chen J, Liu J, Gao S, Qiu Y, Wang Y, Zhang Y, Gao L, Qi G, Wu Y, Lash GE, Li P
Placenta 2021 Jan 1;103:1-9
Placenta 2021 Jan 1;103:1-9
Crosstalk between the activated Slit2-Robo1 pathway and TGF-β1 signalling promotes cardiac fibrosis.
Liu Y, Yin Z, Xu X, Liu C, Duan X, Song Q, Tuo Y, Wang C, Yang J, Yin S
ESC heart failure 2021 Feb;8(1):447-460
ESC heart failure 2021 Feb;8(1):447-460
Deletion of Mea6 in Cerebellar Granule Cells Impairs Synaptic Development and Motor Performance.
Wang XT, Zhou L, Cai XY, Xu FX, Xu ZH, Li XY, Shen Y
Frontiers in cell and developmental biology 2020;8:627146
Frontiers in cell and developmental biology 2020;8:627146
Depression-/Anxiety-Like Behavior Alterations in Adult Slit2 Transgenic Mice.
Huang G, Wang S, Yan J, Li C, Feng J, Chen Q, Zheng X, Li H, He Y, Young AJ, Li H, Li W, Li J, Wang L
Frontiers in behavioral neuroscience 2020;14:622257
Frontiers in behavioral neuroscience 2020;14:622257
Tumoural activation of TLR3-SLIT2 axis in endothelium drives metastasis.
Tavora B, Mederer T, Wessel KJ, Ruffing S, Sadjadi M, Missmahl M, Ostendorf BN, Liu X, Kim JY, Olsen O, Welm AL, Goodarzi H, Tavazoie SF
Nature 2020 Oct;586(7828):299-304
Nature 2020 Oct;586(7828):299-304
Inhibition of miR-200b-3p alleviates hypoxia-ischemic brain damage via targeting Slit2 in neonatal rats.
Zhang N, Yang L, Meng L, Cui H
Biochemical and biophysical research communications 2020 Mar 19;523(4):931-938
Biochemical and biophysical research communications 2020 Mar 19;523(4):931-938
Identification and validation of smoking-related genes in lung adenocarcinoma using an in vitro carcinogenesis model and bioinformatics analysis.
Wang J, Chen T, Yu X, OUYang N, Tan L, Jia B, Tong J, Li J
Journal of translational medicine 2020 Aug 14;18(1):313
Journal of translational medicine 2020 Aug 14;18(1):313
MEA6 Deficiency Impairs Cerebellar Development and Motor Performance by Tethering Protein Trafficking.
Wang XT, Cai XY, Xu FX, Zhou L, Zheng R, Ma KY, Xu ZH, Shen Y
Frontiers in cellular neuroscience 2019;13:250
Frontiers in cellular neuroscience 2019;13:250
Slit2/Robo1 signaling is involved in angiogenesis of glomerular endothelial cells exposed to a diabetic-like environment.
Liu J, Hou W, Guan T, Tang L, Zhu X, Li Y, Hou S, Zhang J, Chen H, Huang Y
Angiogenesis 2018 May;21(2):237-249
Angiogenesis 2018 May;21(2):237-249
Alterted SLIT2/ROBO1 signalling is linked to impaired placentation of missed and threatened miscarriage in early pregnancy.
Li P, Shi Y, Shuai H, Cai Y, Lu W, Wang G, Gao L, Wang L, Fan X, Yang X
Histopathology 2017 Oct;71(4):543-552
Histopathology 2017 Oct;71(4):543-552
Dendrite self-avoidance requires cell-autonomous slit/robo signaling in cerebellar purkinje cells.
Gibson DA, Tymanskyj S, Yuan RC, Leung HC, Lefebvre JL, Sanes JR, Chédotal A, Ma L
Neuron 2014 Mar 5;81(5):1040-1056
Neuron 2014 Mar 5;81(5):1040-1056
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 20217-1-AP(SLIT2-Specific antibody) at dilution of 1:200
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human kidney using 20217-1-AP(SLIT2-Specific antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SLIT2-Specific antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human SLIT2-Specific. This antibody recognizes human,mouse,rat antigen. The SLIT2-Specific antibody has been validated for the following applications: ELISA, WB, IHC analysis.
