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Learn13431-1-AP
antibody from Proteintech Group
Targeting: CYP51A1
CP51, CYP51, CYPL1, LDM, P450-14DM, P450L1
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [22]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- 13431-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#13431-1-AP, RRID:AB_2088571
- Product name
- CYP51A1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CYP51A1 antibody (Cat. #13431-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references 7-Dehydrocholesterol dictates ferroptosis sensitivity.
Bicyclol attenuates high fat diet-induced non-alcoholic fatty liver disease/non-alcoholic steatohepatitis through modulating multiple pathways in mice.
Pregnane X receptor agonist nomilin extends lifespan and healthspan in preclinical models through detoxification functions.
Liver proteomics analysis reveals the differentiation of lipid mechanism and antioxidant enzyme activity during chicken embryonic development.
Schwann Cells Accelerate Osteogenesis via the Mif/CD74/FOXO1 Signaling Pathway In Vitro.
Effects and potential mechanism of Ca(2+)/calmodulin‑dependent protein kinase II pathway inhibitor KN93 on the development of ovarian follicle.
MMAB promotes negative feedback control of cholesterol homeostasis.
Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory.
Vascular biotransformation of organic nitrates is independent of cytochrome P450 monooxygenases.
POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturation.
Quality Control of ER Membrane Proteins by the RNF185/Membralin Ubiquitin Ligase Complex.
Quality Control of ER Membrane Proteins by the RNF185/Membralin Ubiquitin Ligase Complex.
The cholesterol synthesis enzyme lanosterol 14α-demethylase is post-translationally regulated by the E3 ubiquitin ligase MARCH6.
Elevated cellular cholesterol in Familial Alzheimer's presenilin 1 mutation is associated with lipid raft localization of β-amyloid precursor protein.
Endogenous sterol intermediates of the mevalonate pathway regulate HMGCR degradation and SREBP-2 processing.
Pharmacogenomics of Chemically Distinct Classes of Keap1-Nrf2 Activators Identify Common and Unique Gene, Protein, and Pathway Responses In Vivo.
Nitric oxide stimulates cellular degradation of human CYP51A1, the highly conserved lanosterol 14α-demethylase.
Lanosterol Modulates TLR4-Mediated Innate Immune Responses in Macrophages.
Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells.
CYB5D2 requires heme-binding to regulate HeLa cell growth and confer survival from chemotherapeutic agents.
Protective effects of dioscin against alcohol-induced liver injury.
Suppression of cytochrome P450 reductase (POR) expression in hepatoma cells replicates the hepatic lipidosis observed in hepatic POR-null mice.
Li Y, Ran Q, Duan Q, Jin J, Wang Y, Yu L, Wang C, Zhu Z, Chen X, Weng L, Li Z, Wang J, Wu Q, Wang H, Tian H, Song S, Shan Z, Zhai Q, Qin H, Chen S, Fang L, Yin H, Zhou H, Jiang X, Wang P
Nature 2024 Feb;626(7998):411-418
Nature 2024 Feb;626(7998):411-418
Bicyclol attenuates high fat diet-induced non-alcoholic fatty liver disease/non-alcoholic steatohepatitis through modulating multiple pathways in mice.
Wu J, Jia S, Xu B, Yao X, Shao J, Yao J, Cen D, Yao X
Frontiers in pharmacology 2023;14:1157200
Frontiers in pharmacology 2023;14:1157200
Pregnane X receptor agonist nomilin extends lifespan and healthspan in preclinical models through detoxification functions.
Fan S, Yan Y, Xia Y, Zhou Z, Luo L, Zhu M, Han Y, Yao D, Zhang L, Fang M, Peng L, Yu J, Liu Y, Gao X, Guan H, Li H, Wang C, Wu X, Zhu H, Cao Y, Huang C
Nature communications 2023 Jun 8;14(1):3368
Nature communications 2023 Jun 8;14(1):3368
Liver proteomics analysis reveals the differentiation of lipid mechanism and antioxidant enzyme activity during chicken embryonic development.
Shen N, Li C, Yang S, Ma Y, Wang HL
International journal of biological macromolecules 2023 Dec 31;253(Pt 7):127417
International journal of biological macromolecules 2023 Dec 31;253(Pt 7):127417
Schwann Cells Accelerate Osteogenesis via the Mif/CD74/FOXO1 Signaling Pathway In Vitro.
Li JQ, Jiang HJ, Su XY, Feng L, Zhan NZ, Li SS, Chen ZJ, Chang BH, Cheng PZ, Yang L, Pei GX
Stem cells international 2022;2022:4363632
Stem cells international 2022;2022:4363632
Effects and potential mechanism of Ca(2+)/calmodulin‑dependent protein kinase II pathway inhibitor KN93 on the development of ovarian follicle.
Yu J, Xie X, Ma Y, Yang Y, Wang C, Xia G, Ding X, Liu X
International journal of molecular medicine 2022 Oct;50(4)
International journal of molecular medicine 2022 Oct;50(4)
MMAB promotes negative feedback control of cholesterol homeostasis.
Goedeke L, Canfrán-Duque A, Rotllan N, Chaube B, Thompson BM, Lee RG, Cline GW, McDonald JG, Shulman GI, Lasunción MA, Suárez Y, Fernández-Hernando C
Nature communications 2021 Nov 8;12(1):6448
Nature communications 2021 Nov 8;12(1):6448
Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory.
Li X, Zhang J, Li D, He C, He K, Xue T, Wan L, Zhang C, Liu Q
Neuron 2021 Mar 17;109(6):957-970.e8
Neuron 2021 Mar 17;109(6):957-970.e8
Vascular biotransformation of organic nitrates is independent of cytochrome P450 monooxygenases.
Lopez M, Malacarne PF, Gajos-Draus A, Ding X, Daiber A, Lundberg JO, Offermanns S, Brandes RP, Rezende F
British journal of pharmacology 2021 Apr;178(7):1495-1506
British journal of pharmacology 2021 Apr;178(7):1495-1506
POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturation.
Xiao J, Xiong Y, Yang LT, Wang JQ, Zhou ZM, Dong LW, Shi XJ, Zhao X, Luo J, Song BL
Protein & cell 2021 Apr;12(4):279-296
Protein & cell 2021 Apr;12(4):279-296
Quality Control of ER Membrane Proteins by the RNF185/Membralin Ubiquitin Ligase Complex.
van de Weijer ML, Krshnan L, Liberatori S, Guerrero EN, Robson-Tull J, Hahn L, Lebbink RJ, Wiertz EJHJ, Fischer R, Ebner D, Carvalho P
Molecular cell 2020 Sep 3;79(5):768-781.e7
Molecular cell 2020 Sep 3;79(5):768-781.e7
Quality Control of ER Membrane Proteins by the RNF185/Membralin Ubiquitin Ligase Complex.
van de Weijer ML, Krshnan L, Liberatori S, Guerrero EN, Robson-Tull J, Hahn L, Lebbink RJ, Wiertz EJHJ, Fischer R, Ebner D, Carvalho P
Molecular cell 2020 Oct 15;80(2):374-375
Molecular cell 2020 Oct 15;80(2):374-375
The cholesterol synthesis enzyme lanosterol 14α-demethylase is post-translationally regulated by the E3 ubiquitin ligase MARCH6.
Scott NA, Sharpe LJ, Capell-Hattam IM, Gullo SJ, Luu W, Brown AJ
The Biochemical journal 2020 Jan 31;477(2):541-555
The Biochemical journal 2020 Jan 31;477(2):541-555
Elevated cellular cholesterol in Familial Alzheimer's presenilin 1 mutation is associated with lipid raft localization of β-amyloid precursor protein.
Cho YY, Kwon OH, Park MK, Kim TW, Chung S
PloS one 2019;14(1):e0210535
PloS one 2019;14(1):e0210535
Endogenous sterol intermediates of the mevalonate pathway regulate HMGCR degradation and SREBP-2 processing.
Chen L, Ma MY, Sun M, Jiang LY, Zhao XT, Fang XX, Man Lam S, Shui GH, Luo J, Shi XJ, Song BL
Journal of lipid research 2019 Oct;60(10):1765-1775
Journal of lipid research 2019 Oct;60(10):1765-1775
Pharmacogenomics of Chemically Distinct Classes of Keap1-Nrf2 Activators Identify Common and Unique Gene, Protein, and Pathway Responses In Vivo.
Wible RS, Tran QT, Fathima S, Sutter CH, Kensler TW, Sutter TR
Molecular pharmacology 2018 Apr;93(4):297-308
Molecular pharmacology 2018 Apr;93(4):297-308
Nitric oxide stimulates cellular degradation of human CYP51A1, the highly conserved lanosterol 14α-demethylase.
Park JW, Byrd A, Lee CM, Morgan ET
The Biochemical journal 2017 Sep 14;474(19):3241-3252
The Biochemical journal 2017 Sep 14;474(19):3241-3252
Lanosterol Modulates TLR4-Mediated Innate Immune Responses in Macrophages.
Araldi E, Fernández-Fuertes M, Canfrán-Duque A, Tang W, Cline GW, Madrigal-Matute J, Pober JS, Lasunción MA, Wu D, Fernández-Hernando C, Suárez Y
Cell reports 2017 Jun 27;19(13):2743-2755
Cell reports 2017 Jun 27;19(13):2743-2755
Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells.
Head SA, Shi W, Zhao L, Gorshkov K, Pasunooti K, Chen Y, Deng Z, Li RJ, Shim JS, Tan W, Hartung T, Zhang J, Zhao Y, Colombini M, Liu JO
Proceedings of the National Academy of Sciences of the United States of America 2015 Dec 29;112(52):E7276-85
Proceedings of the National Academy of Sciences of the United States of America 2015 Dec 29;112(52):E7276-85
CYB5D2 requires heme-binding to regulate HeLa cell growth and confer survival from chemotherapeutic agents.
Bruce A, Rybak AP
PloS one 2014;9(1):e86435
PloS one 2014;9(1):e86435
Protective effects of dioscin against alcohol-induced liver injury.
Xu T, Zheng L, Xu L, Yin L, Qi Y, Xu Y, Han X, Peng J
Archives of toxicology 2014 Mar;88(3):739-53
Archives of toxicology 2014 Mar;88(3):739-53
Suppression of cytochrome P450 reductase (POR) expression in hepatoma cells replicates the hepatic lipidosis observed in hepatic POR-null mice.
Porter TD, Banerjee S, Stolarczyk EI, Zou L
Drug metabolism and disposition: the biological fate of chemicals 2011 Jun;39(6):966-73
Drug metabolism and disposition: the biological fate of chemicals 2011 Jun;39(6):966-73
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The CYP51A1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CYP51A1. This antibody recognizes human, mouse, rat antigen. The CYP51A1 antibody has been validated for the following applications: ELISA, WB analysis.
