FNab00355

antibody from FineTest Biotech

Targeting: AMACR P504S, RACE

Western blot

ELISA

Immunohistochemistry

Antibody data

Submit

Validation data

Product number: FNab00355 - Provider product page
Provider: FineTest Biotech
Product name: AMACR/p504S antibody
Antibody type: Polyclonal
Antigen: Recombinant protein fragment
Description: AMACR(Alpha-methylacyl-CoA racemase) belongs to the CaiB/BaiF CoA-transferase family. It is a mitochondrial and peroxisomal enzyme that catalyzes the conversion of 2R stereoisomers of phytanic and pristanic acid to their S counterparts. AMACR has previously been shown to be a highly sensitive marker for colorectal and clinically localized prostate cancer(PCa). However, AMACR expression is down-regulated at the transcript and protein level in hormone-refractory metastatic PCa, suggesting a hormone-dependent expression of AMACR(PMID:12213712). It has 3 isoforms produced by alternative splicing ang it can form a a dimer of 70-75 kDa(PMID:21812041). Defects in AMACR are the cause of alpha-methylacyl-CoA racemase deficiency(AMACRD) and congenital bile acid synthesis defect type 4(CBAS4).
Reactivity: Human, Rat
Host: Rabbit
Conjugate: Unconjugated
Antigen sequence: alpha-methylacyl-CoA racemase
Epitope: IgG
Isotype: IgG
Vial size: 100¦Ìg
Concentration: Immunogen affinity purified
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
Handling: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)

AMACR protein structure - FNab00355 shown in red.