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- References [3101]
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- Product number
- 12789-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12789-1-AP, RRID:AB_2227948
- Product name
- BCL2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated BCL2 antibody (Cat. #12789-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: FC, IHC, IP, WB, ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Integrated single-cell transcriptomics and proteomics elucidate the molecular mechanisms and detoxification strategy of rifampicin-induced hepatotoxicity.
Hsa_circ_0000313/miR-1224-3p/MKNK2 Axis Modulates CD4(+) T Cells by Activating p38 MAPK Signaling in Myasthenia Gravis.
Targeting Pulmonary Hypertension: Elucidating Sophocarpine's Protective Role via Preclinical Models.
Epithelial Gab1 Restricts Sepsis-Induced Intestinal Injury by Orchestrating TNF/NF-κB Axis.
A cyclometalated iridium(III) complex induces paraptotic cell death via mitochondrial dysfunction and ER stress in triple-negative breast cancer cells.
Prognostic significance of calcium signaling-related genes in bladder cancer and the role of ATP2B4 in regulating mitochondrial calcium ion levels via the VDAC1/MCU pathway.
The brain imaging feature-related gene NRP2 drives the malignant progression of glioblastoma through the FAK pathway: a Mendelian randomization study.
PLOD2 Promotes Cutaneous Squamous Cell Carcinoma Progression in Association With STAT3-Related ERK and AKT Pathways.
miR-329-3p derived from mast cells-exosomes exacerbates intestinal ischemia-reperfusion injury by targeting ATG10 to regulate autophagy.
Seminal plasma extracellular vesicle-derived miR-296-3p targets PLA2G6 to enhance boar sperm motility by lowering Lys Phosphatidylcholine.
Exosomes derived from Bcl-2-engineered iPSC-cardiomyocytes mitigate aortic valve calcification and inhibit cardiomyocyte apoptosis.
Febrifugine dihydrochloride restricts porcine epidemic diarrhea virus replication by modulating the IGF1R-driven PI3K/AKT-apoptosis axis.
Eriodictyol mitigates polystyrene nanoplastic-induced ovarian toxicity via targeted inhibition of the TLR4/NF-κB/NLRP3 inflammatory axis.
Prenylterphenyllin, a regulator of P53, inhibits colorectal cancer progression through oxidative stress and energy metabolism pathway.
Development and characterization of endolysosomal trafficking targeting chimera degraders of α(1A)-adrenergic receptor.
Senolytic elimination of therapy-induced senescent cells by ABT-263 improves chemotherapeutic efficacy in esophageal squamous cell carcinoma.
Ubiquitin-specific peptidase 40 promotes cellular proliferation and inhibits apoptosis through deubiquitination-mediated stabilization of c-MYC in acute myeloid leukemia.
A triple combination strategy for nasopharyngeal carcinoma: Aptamer-guided liposomal chemotherapy, engineered NK cells, and Fc-enhanced PD-L1 antibody therapy.
AURKA Activates FOXO3a to Form a Positive Feedback Loop in the Proliferation and Migration of Keloid Fibroblasts.
Albiflorin Relieves Intervertebral Disc Degeneration Through Inhibiting Nucleus Pulposus Cell via the p38 MAPK/NF-κB Pathway.
DUSP4 mitigates doxorubicin-induced cardiotoxicity via the p38 MAPK/MK2 signaling pathway.
Acid Ceramidase Inhibition Disrupts Ceramide Homeostasis and Induces Mitochondrial Apoptosis in IDH1-Mutant Oligodendroglioma.
DIDS modulates VDAC1 oligomerization to suppress intrinsic apoptosis and attenuates in vitro and in vivo RSV infection.
Dual targeting of PI3Kδ and PPARα enhances antitumor activity via FoxO1 activation in follicular lymphoma.
Biomimetic Nanoplatform for Targeted Glioblastoma Therapy via Concurrently Triggering GPX4/DHODH Mediated Ferroptosis.
PEAR1/EAF1 deficiency impairs aspirin responsiveness in atherosclerotic endothelium: A novel mechanism of atypical aspirin resistance.
NRF2 Drives Aggressiveness and Chemoresistance in Ovarian Cancer Stem-like Cells.
FBXO3-mediated DUSP9 ubiquitination promotes leukemia stem cell maintenance and tyrosine kinase inhibitor resistance in chronic myeloid leukemia.
Study on the effects and mechanisms of M2 macrophages on PYCR1-promoted biological behavior of hepatocellular carcinoma cells.
Glycolytic metabolic reprogramming and mitochondrial dysfunction: A novel mechanism underlying PAEs-promoted cartilage inflammatory phenotype.
circKANSL1 promotes immature porcine Sertoli cell growth via recruiting the Vimentin to enhance its parental gene KANSL1 expression.
RRP9 suppresses hepatocellular carcinoma progression by inhibiting the PI3K/AKT/mTOR pathway.
Leveraging ANXA1 to enhance recombinant protein yields in CHO cells: A UPR-Mediated bioprocessing approach.
Therapeutic mechanism of Changyong Decoction in suppressing colorectal cancer progression and inducing ferroptosis via the PIEZO1-PI3K/AKT signaling axis.
Exploring the molecular mechanism of Shenling baizhu formula in the treatment of ulcerative colitis via the cGMP-PKG signaling pathway.
Mitochondria-targeting iridium(III) complex enhances anticancer activity via PDK inhibition and energy metabolism disruption.
Inhibition of endothelial ALOX12 mitigates cerebral ischemia-reperfusion injury by suppressing 12-HETE.
Primase subunit 2 regulates the proliferation and apoptosis of gastric cancer cells via MCM7/CDK4 and Bax/Bcl-2 pathways.
The function and molecular mechanism of HIF-1α interacted with p-STAT3 in promoting G6PD overexpression in chronic myelogenous leukemia cells.
CMTM6 promotes synovial proliferation and macrophage polarization by preventing ubiquitination of TAK1 in rheumatoid arthritis.
Lopinavir/ritonavir induces hepatotoxicity in HepG2 cells through inhibition of the Nrf2 pathway, resulting in oxidative stress, endoplasmic reticulum stress, and cell cycle arrest.
Narirutin Reprograms Fatty Acid Metabolism and Inhibits Tumorigenesis via Downregulating ADORA3 Expression in Colorectal Cancer.
Transcriptomic analysis identifies CXCL12 as a novel candidate gene for litter size in rabbits.
Neutrophil/Leukemia-Tropic Dual-Drug Nanomedicine Potentiates the Treatment of Acute Myeloid Leukemia.
TRIM32 promotes anoikis resistance and metastasis in NSCLC by degrading CHEK2 to enhance IL-6 secretion.
IMPDH2 facilitates CD4+ T cell activation through AKT/mTOR pathway by upregulating SRPK1 in myasthenia gravis.
Hesperadin sensitizes gastric cancer cells to cisplatin via NOX1-dependent oxidative stress.
Sesamin exerts protective effects against diquat-induced acute kidney injury by inhibiting oxidative stress, apoptosis and autophagy: A key role for the SIRT5/FOXO3a signaling pathway.
Mechanism of Brucella pathogenesis mediated by outer membrane protein Omp19: Synergistic activation of cytokine storm and dual apoptotic pathways.
The α5-nAChR/GINS4 axis contributed to nicotine-promoted lung adenocarcinoma progression.
Unraveling the role of host kinase PIM1 in Toxoplasma gondii infection: Implications for therapies.
Carnosic Acid Mediates Production of Reactive Oxygen Species to Regulate Mitogen-Activated Protein Kinase Pathway Phosphorylation and Induce Apoptosis in Human Breast Cancer Cells.
Paeoniflorin Ameliorates Spinal Cord Injury by Controlling Apoptosis and Ferroptosis in H(2)O(2)-Damaged PC12 Cells.
A pH-Responsive Biomimetic Antioxidant Nanoplatform with Dual Renal Targeting for Synergistic Therapy of Acute Kidney Injury.
Identifying C1orf122 as a potential HCC exacerbated biomarker dependently of SRPK1 regulates PI3K/AKT/GSK3β signaling pathway.
HSP90AA1 restrains clear cell renal cell carcinoma progression by promoting CADM1 expression and suppressing the PI3K-AKT pathway through interaction with FBXO7.
Cucurbitacin B Inhibits Hepatocellular Carcinoma by Inducing Ferroptosis and Activating the cGAS-STING Pathway.
SULT1E1 exerts a protective role in COPD by inhibiting the AKT pathway: an in vivo and in vitro study.
NUSAP1 Drives Endometrial Carcinoma via IP3R Phosphorylation, Calcium Dyshomeostasis, and ER-Stress-Mediated Apoptosis.
MMSA-1 is regulated by Wnt/TCF4 and involved in multiple myeloma progression and invasion via RAS/RAF signaling pathway.
Asiatic acid reverses cisplatin resistance in A549/DDP cells by activating the P38 MAPK/Slug pathway.
Saikosaponin D overcomes gemcitabine resistance in pancreatic cancer via AKT/mTOR pathway inhibition and synergistic induction of apoptosis and autophagy.
Inhibition of primary ciliogenesis enhances efficacy of EGFR‑TKIs against non‑small cell lung cancer cells.
USP3 stabilizes MIC19 by deubiquitination under hypoxic stress and promotes the progression of non-small cell lung cancer.
A novel biomimetic nanozyme orchestrates ulcerative colitis resolution by targeting KEAP1-NRF2-ARE pathway: Redox balance restoration, colonic barrier repair, immune homeostasis regulation.
FGF2 Enhances MSCs Secretome Therapy for Skin Photoaging by Delaying Senescence via iNAMPT/AMPK Signaling and Facilitating eNAMPT-Mediated Regenerative Crosstalk.
OCIAD2-IQGAP1 interaction promotes pancreatic cancer progression by suppressing oxidative stress and mitochondria-mediated apoptosis.
AI-Driven Acceleration of Fluorescence Probe Discovery.
A trifluoromethyl quinoline derivative targets SGK1 and modulates the PI3K/AKT pathway to inhibit prostate cancer progression.
Magnesium silicate nanosheets enable sustained hydrogen release to attenuate secondary brain injury following intracerebral hemorrhage.
Cardiac PTN-SIRT1 axis alleviates oxidative stress and promotes mitochondrial energy reprogramming to mitigate doxorubicin-induced cardiotoxicity through AMPK/PGC1α signaling.
Bioinformatic analysis and cellular functional assays uncover the role of NXPH4 in breast cancer.
Lidocaine potentiates thermal ablation in cholangiocarcinoma by modulating TRPV6-Driven Ca(2+)/PI3K/AKT/HSF-1 signaling pathway.
Cepharanthine alleviated chronic prostatitis/chronic pelvic pain syndrome by activating Nrf2 and inhibiting the NF-κB pathway.
FBXO22 targets ubiquitination and degradation of c-Cbl in leukemia.
Activated Rac1 promotes chondrocyte apoptosis through the NF-κB pathway in lumbar facet joint osteoarthritis.
A stimuli-responsive mitochondria-targeted nanoplatform for glioblastoma therapy: modulating the blood-brain barrier and delivering precise chemotherapy.
DNMT3b promotes proliferation and invasion by mediating HOPX DNA methylation in lung cancer.
Curcumin-loaded silk fibroin scaffold promotes cartilage regeneration by inhibiting angiogenesis via Drp1/ROS-mediated mitochondrial regulation.
A human patient-derived organoid biobank to model tumor heterogeneity and therapeutic vulnerability for oral squamous cell carcinoma.
A Novel Pyrazole Pyrimidine Derivative MBP346 Induces Cell Death via ROS-Mediated Mitochondrial Damage in Human Head and Neck Squamous Cell Carcinoma.
Growth differentiation factor 15 promotes the malignant progression of multiple myeloma via activation of PI3K/Akt/NF-κB signaling pathway.
CircRNA-TMEM71 Inhibits Human Aortic Smooth Muscle Cell Ferroptosis and Prevents Aortic Dissection Formation Through IGF2BP3-Mediated Stability of FSP1.
S100A10 promotes glycolysis and malignant progression of CCA by activating the HK2/ERK signaling pathway.
AFP confers the resistance of lenvatinib in hepatocellular carcinoma by activating PI3K/AKT/LDHA signaling axis.
Hijacking the Hydrogen Sulfide Axis: A Novel 4-Trifluoromethylquinoline Derivative Suppresses Glioblastoma via Cystathionine γ-Lyase Suppression.
14-3-3β knockdown inhibits migration and colony formation of esophageal squamous cell carcinoma cells and is associated with weakened p-AKT signaling.
T-cell apoptosis is more susceptible to overactivated neutrophils delivered-NETs-MPO/NE complex.
DNA Methylation-Regulated FAM107A Affects Colorectal Carcinogenesis by Inhibiting FOXM1.
RFRP-3 suppresses ovarian granulosa cell function in Tan sheep via dual signaling pathways: PI3K/AKT/mTOR and MAPK/ERK1/2.
Intermittent theta-burst stimulation promotes neurovascular unit remodeling after ischemic stroke in a mouse model.
Maintaining a balanced Bcl-2/Bax ratio and increased antioxidant capacity in tissue and mitochondria inhibits apoptosis in goose fatty liver.
NSUN3-Mediated ROS Accumulation Promotes Hepatocellular Carcinoma Proliferation and Activates PI3K/AKT Pathway.
Nanomagnetic Hyperthermia Sensitizes Gemcitabine Chemosensitivity in Pancreatic Cancer by Inhibiting HSPB1 to Amplify ACSL4-Mediated Ferroptosis.
Co-exposure to polystyrene nanoplastics and hexachlorocyclohexane induces enhanced human sperm toxicity in vitro.
GATA6 inhibits the periodontitis progression through regulating the Notch signaling pathway.
Antitumor Cytisine-Platinum(IV) Prodrugs Potentiate Crosstalk between Endoplasmic Reticulum and Mitochondria through Calcium Overload Accompanied by Immunogenic Cell Death.
MiR-93-5p Loaded Lipid Nanoparticles Break the Dry Eye Vicious Cycle via Targeting MAP3K8.
Discovery of indolinone-based covalent ULK1 inhibitors that suppressed autophagy and induced apoptosis against colorectal carcinoma.
Selective Radioprotection by the Fusion Antioxidant Enzyme GS1XR Via an MMP-2/9-Cleavable Cell-Penetrating Switch.
Triple-Targeted Peptide-Photosensitizer-Drug Conjugate Enables NIR-II Imaging-Guided Multimodal Therapy Against Osteosarcoma.
Cancer-Associated Fibroblast-Derived Sphingosine-1-Phosphate Activates a MALL-SDC4 Axis to Facilitate Perineural Invasion in Pancreatic Cancer.
KLOTHO Deficiency Drives Ovarian Aging by Inducing Granulosa Cell Senescence and Dysfunction.
Aberrant expression of TRIM26 suppresses ferroptosis through regulating GPX4 protein stability in colorectal cancer.
Methylation of tenascin XB mediated by methyltransferase-like 3 can effectively suppress neural injury and cellular apoptosis induced by ischemic stroke.
Phenethyl Isothiocyanate Suppresses Hepatocellular Carcinoma Progression and Immune Evasion via ZNF652 Regulation of PD-L1.
Recombinant tissue plasminogen activator protects neurons after intracerebral hemorrhage through activating the PI3K/AKT/mTOR pathway.
Inhibition of mitochondrial RNA polymerase sensitizes cancer cells to radiation by inhibiting mitochondrial respiration.
FR429 from Polygonum capitatum Demonstrates Potential as an Anti-hepatic Injury Agent by Modulating PI3K/Akt Signaling Pathway.
Terpinen-4-ol suppresses proliferation and motility of cutaneous squamous cell carcinoma cells by enhancing calpain-2 expression.
Effect of anemoside B4 on ameliorating cerebral ischemic/reperfusion injury.
Transcriptional enhanced associate domain factor 1 regulates cortactin-binding protein 2 N-terminal-like to control cell apoptosis in thyroid cancer.
Ailanthone inhibits bladder cancer tumor and cell proliferation, epithelial-mesenchymal transition, and activation of the Janus kinase/signal transducer and activator of transcription 3 signaling pathway.
BCLAF1 Regulates Osteoarthritic Cartilage Degradation Through Interaction with LAMTOR2.
Expression Profile of Urinary Exosomal miRNAs in Patients With Diabetic Kidney Disease and Their Association With Kidney Damage.
SphK1 Suppresses Human Dental Pulp Stem Cell Apoptosis by Promoting Glycolysis Under Simulated Microgravity.
Caffeine Alleviates Oxidative Damage of Retinal Pigment Epithelium Cells.
TRIM6 affects the prognosis of acute myeloid leukemia through the PI3K/AKT signaling pathway and is associated with immune infiltration.
Altered Bcl-2/Caspase signaling and hypoxia-induced apoptosis in primary human aniridia limbal stromal cells, in CoCl2 mediated hypoxic stress, in vitro.
PPARγ inhibitors enhance the efficacy of statin therapy for steroid-induced osteonecrosis of the femoral head by directly inhibiting apoptosis and indirectly modulating lipoprotein subfractions.
Downregulation of OIP5-AS1 inhibits apoptosis in myocardial ischemia/reperfusion injury via modulating the MiR-145-5p/ROCK1 axis.
High SRD5A3 expression is correlated with promotion of proliferation and inhibition of apoptosis in B-cell non-Hodgkin lymphoma and suggests a poor prognosis.
Antioxidative and anticancer effects of Tacca chantrieri extract enhancing cisplatin sensitivity in cholangiocarcinoma cells.
Lathyrol affects the expression of AR and PSA and inhibits the malignant behavior of RCC cells.
Polyallylamine Hydrochloride-Modified Bovine Serum Albumin Nanoparticles Loaded with α-Solanine for Chemotherapy of Pancreatic Cancer.
Hypericin Nanoparticles-Associated Photodynamic Therapy Modulates the Biological Behavior of Hepatocellular Carcinoma by SERPINE1.
Hepatic Stellate Cell TM4SF1 Accelerates Hepatic Fibrosis Progression via Interacting With the Tyrosine Kinase c-Src.
MFAP4 Deficiency Attenuates Liver Fibrosis by Regulating Hepatic Stellate Cell Fate Through Inhibition of the FAK/PI3K/NFκB Signaling Pathway.
RET Inhibitor SPP86 Triggers Apoptosis and Activates the DNA Damage Response Through the Suppression of Autophagy and the PI3K/AKT Signaling Pathway in Melanoma Cells.
Network Pharmacology, Molecular Docking, and in vitro Experiments Reveal the Role and Mechanism of Tanshinone IIA in Colorectal Cancer Treatment Through the PI3K/AKT Pathway.
Blockade of the Notch Pathway by Inhibition of Fucosylation Ameliorates Chondrocyte Inflammation and Extracellular Matrix Degradation.
Lasalocid inhibits melanoma by down-regulating FOXM1 through PI3K/AKT and JNK/P38 MAPK pathways.
Longikaurin A, a natural ent-kaurane, suppresses proliferation, invasion and tumorigenicity in oral squamous cell carcinoma cell by via inhibiting PI3K/Akt pathway in vitro and in vivo.
Cardamonin induces apoptosis of colorectal cancer cells via targeted inhibition of the JAK/STAT3/epithelial-mesenchymal transition (EMT) signaling axis.
Efferocytosis-associated genes serve as prognostic biomarkers for pancreatic ductal adenocarcinoma and identify P2RY6 as a therapeutic target.
Association of genetically instrumented HMGCR inhibition with the therapeutic role of prostate cancer: a Mendelian randomization study and supporting in vitro experiments.
Unveiling the novel value of TREM1 in the proneural-mesenchymal transition of glioma via tumor-associated macrophages.
Machine learning integration with multi-omics data constructs a robust prognostic model and identifies PTGES3 as a therapeutic target for precision oncology in lung adenocarcinoma.
Chrysin sensitizes glioblastoma cells and spheroids to temozolomide treatment by reducing EMT and stemness phenotypes, as well as targeting multidrug resistance proteins.
Analyzing the potential targets and mechanisms of liver damage induced by acetyl tributyl citrate plasticizer using network toxicology, molecular docking and in vitro experiments.
Ailanthone induces apoptosis in U-2OS cells through the endoplasmic reticulum stress.
The function of CD164 in breast cancer and its possibility as a molecular biomarker: bioinformatics analysis and experimental validation.
IGF-1 secreted by mesenchymal stem cells affects the function of lymphatic endothelial progenitor cells: a potential strategy for the treatment of lymphedema.
Targeting the BAG2/CHIP axis promotes gastric cancer apoptosis by blocking apoptosome assembly.
Androgen receptor inhibitor ameliorates pulmonary arterial hypertension by enhancing the apoptosis level through suppressing the Notch3/Hes5 pathway.
Congrong Shujing Granules ameliorates mitochondrial associated membranes to against MPP(+)-induced neurological damage in the cellular model of Parkinson's disease.
Genipin attenuates oxidative damage in periodontal tissues by alleviating mitochondrial dysfunction and abnormal glucose uptake through inhibition of UCP2.
Cyclic mechanical stretching enhances mitophagy and oxidative stress resistance in adipose-derived stem cells via the Piezo1/ATP axis to accelerate wound healing.
Oxidative stress-mediated PANoptosis and ferroptosis: Exploration of multimodal cell death triggered by an AIE-active nano-photosensitizer via photodynamic therapy.
Mechanism of active component β-sitosterol from Myristica fragrans inducing apoptosis in bladder cancer cells via regulating the BCL-2/BAX/caspase-3 pathway.
CMSP suppresses oral squamous cell carcinoma progression by targeting the JAK2/STAT3/c-Myc axis.
SATB2 promotes radiation resistance of esophageal squamous cell carcinoma by regulating epithelial-to-mesenchymal transition via the Wnt/β-catenin pathway.
Identification and functional characterization of m1A-related genes in colorectal cancer: implications for prognosis, immune infiltration, and therapeutic strategies.
Acetylated Dendrobium huoshanense polysaccharide: a novel inducer of apoptosis in colon cancer cells via Fas-FasL pathway activation and metabolic reprogramming.
BNC1 inhibits the development and progression of gastric cancer by regulating the CCL20/JAK-STAT axis.
Hydroxyurea mitigates diabetic kidney disease through mTOR-S6K signaling pathway in STZ-induced diabetic mice.
Knockdown of annexin A2 enhances the host cell apoptosis induced by Eimeria tenella.
Jianpi-Qinghua Formula alleviates liver dysfunction by suppression of HBV replication in HepG2.2.15 cells.
Synergistic Inhibition of Prostate Cancer Progression in Mice With a Combination of Curcumin and Ursolic Acid in the Diet.
Tremella fuciformis Polysaccharides Alleviate Early Brain Injury in Experimental Subarachnoid Hemorrhage by Inhibiting the KDR-Mediated P38 MAPK/NF-κB Pathway.
Oridonin Ameliorates Metabolic-Dysfunction-Associated Fatty Liver Disease by Inhibiting PANoptosis via Modulating SIRT2/NLRP3 Pathway.
A Small Molecular Weight Saccharide Fraction From Panax quinquefolium L. Inhibited Non-Small Cell Lung Cancer via Endoplasmic Reticulum-Stress Mediated Apoptosis.
Puerarin Attenuates Osteoarthritis via Multi-Target Regulation of Inflammation, Apoptosis, and ECM Degradation.
The m6A transferase METTL3 regulates high glucose-induced proliferation and apoptosis of human lens epithelial cells through the lncRNA TUG1/KHSRP/p38MAPK signaling axis.
PINK1-mediated mitochondrial autophagy protects lens epithelial cells by reducing ROS and apoptosis.
Mito-tempo ameliorates tubular injury of diabetic nephropathy via inhibiting mt-dsRNA release and PKR/eIF2α pathway activation.
Potent Anti-Cancer Activity of Benzo[d]Thiazole-Isatin Conjugates: Induces S Phase Arrest and Cell Necrosis in A549 and HepG2 Cells.
Zinc Transporter 9 (ZnT9) Improves Obesity-Induced Asthenospermia by Attenuating Endoplasmic Reticulum Stress (ERS).
Knockdown of STK39 inhibits lung cancer brain metastasis by suppressing the CPSF4/NFκB/COX2 pathway.
Magnolin Promotes PINK1-Parkin-mediated Mitophagy in Diffuse Large B-cell Lymphoma Cells via PPAR-γ Pathway.
Rhizoma Panacis Majoris ameliorates rheumatoid arthritis by restoring apoptosis and autophagy dysregulation through reducing HMGB1 expression.
Isodeoxyelephantopin Promotes Cell Death in Triple-Negative Breast Cancer by Blocking STAT3 Phosphorylation and Enhancing the Effectiveness of Paclitaxel.
Knocking Down SKA1 Inhibits Hepatocellular Carcinoma Progression via Apoptosis: Integrating Single-Cell Transcriptomics With In Vivo and In Vitro Validation.
Prepubertal Diabetes Stagnates Testicular Development by Skewing Autophagy Homeostasis in Leydig Cells.
LncRNA LOXL1-AS1 promotes ovarian cancer progression by enhanced BRIP1 mRNA stability.
Comparison of Quercetin and Isoquercitrin's Anti-Heart Failure Activity via MAPK Inflammatory Pathway and Caspase Apoptosis Pathway.
Synthesis and antitumor activity of steroid-based imidazolium salts.
Self-Assembling Amphiphilic Peptides Target the VDAC1-Hexokinase-II Complex to Induce Apoptosis in Cervical Carcinoma Cells.
Epalrestat, an aldose reductase inhibitor, mitigates doxorubicin-induced cardiotoxicity by inhibiting glycometabolism.
Transcriptomic bioinformatics analysis proposes a novel BCL2-MAPK14-TXN oxidative stress diagnostic model of sepsis and identifies TXN as an oxidative stress-related signature gene in sepsis.
Puerarin Inhibits Proliferation, Migration and Invasion of Colon Cancer Cells and Induces Apoptosis via Suppression of the PI3K/AKT Signaling Pathway.
Exploring the potential mechanisms of Jinglinzi powder in treating hepatocellular carcinoma based on LC-MS, network pharmacology, molecular docking, and experimental validation.
Dectin-1 Drives Diabetic Retinopathy via Inducing Microglia-Mediated Inflammation and Blood-Retinal Barrier Breakdown.
POM121 induces chemoresistance toward cisplatin in non-small cell lung cancer.
Glycyrrhizic Acid Inhibits Hippocampal Neuron Apoptosis by Activating the PI3K/ AKT Signaling Pathway.
Oxytocin Regulated Neuroinflammation through OTR/Mitochondria Mediated Pathway to Improve Hypoxia-Induced Brain Injury.
Ribociclib derivative Rib-CA suppresses breast cancer progression via p53-dependent apoptosis.
CCP1 Inhibits Pulmonary Fibrosis by Suppressing Fibrotic Progression Through the EIF4B/PI3K/AKT Pathways.
MiRNA-634 promotes apoptosis in HEI-OC1 cells by regulating AK4 and AKT/mTOR signaling pathways.
Aspirin-Inspired 6-O-Carboxymethyl-N-Acetylglucosamine: A potent antitumor agent with enhanced efficacy.
Honokiol protects against heavy-ion radiation-induced oxidative damage via the thioredoxin system.
Perfluorohexane sulfonate (PFHxS) induces liver cytotoxicity by activating autophagy and endoplasmic reticulum stress-regulated mitochondrial pathway apoptosis.
miR-204-5p Mitigates Disc Degeneration via SKI-Mediated Modulation of Apoptotic Signaling and Matrix Remodeling in Nucleus Pulposus.
Exploring the mechanism of Levistolide A in the treatment of lung cancer cells based on network analysis, molecular docking and experimental validation.
Dihydrocapsaicin attenuates oxidative stress and apoptosis in acute myocardial infarction via promoting Raf-1/ASK1 complex formation.
IL-10 alleviates ulcerative colitis by regulating mitochondrial function through reducing ISG15 expression.
Aerobic exercise alleviates chronic allergic airway inflammation by regulating the circMETTL9/EIF4A3/IGFBP3 axis.
BCL-2 Inhibitor Regulates Number, Function, and Antitumor Immunity of T Cells by Influencing Glycolysis in AML.
Arbutin improves lung injury in chicks induced by Mycoplasma gallisepticum infection.
Development of a CD9-Targeted Radiopharmaceutical for Imaging and Radionuclide Therapy in CD9-Positive Glioma.
Arginyl-fructosyl-glucose (AFG), a major Maillard reaction product of red ginseng, improved kidney and pancreatic injury in vitro and in vivo in type 2 diabetes mellitus.
Novel magnolol-sulforaphane hybrids as potent antitumor agents: synthesis and biological characterization.
Paeoniflorin inhibits glioblastoma proliferation and promotes autophagy through the AKT/mTOR pathway.
miR-7704-Enriched Stem Cell-Derived Extracellular Vesicles Attenuate Hyperoxia-Induced Apoptosis and Oxidation in Lung Epithelial Cells.
Eleutheroside E Ameliorates D-Gal-Induced Senescence in Human Skin Fibroblasts Through PI3K/AKT Signaling.
Mesenchymal stem cells inhibit mitochondrial fission by upregulating armadillo repeat containing 1, ameliorating oxidative stress in renal fibrosis.
Neuroprotective Effects and Mechanisms of Arecoline Against H(2)O(2)-Induced Damage in SH-SY5Y Cells.
Cephalomannine as in vitro and in vivo anticancer agent in mesothelioma cells: mechanisms of action.
TRAP1 inhibits KANSL3 acetylation to alleviate mitochondrial dysfunction by promoting mitophagy in cardiomyocytes under diabetic conditions.
Structural elucidation of an unusual acid heteropolysaccharide with moieties of glucuronogalactoarabinan and glucuronoarabinogalactan from young shoots of Aralia elata (Miq.) Seem.
Epigenetic regulation by WTAPP1 promotes trophoblast dysfunction in gestational diabetes via CNR1/NF-κB activation.
Novel E-F ring derivatives of aconitine scaffold as potent Hsp90 inhibitors for the treatment of colorectal cancer.
Pterostilbene as a pyroptosis inducer and tumor microenvironment regulator inhibits glioblastoma and enhances the efficacy of immunotherapy.
Rab26-mediated lysosomal translocation of eEF1A alleviates myocardial hypertrophy and cardiac remodeling.
Mangiferin targets PFKFB3 to inhibit glioblastoma progression by suppressing glycolysis and PI3K/AKT/mTOR signaling.
Harnessing TP73‑targeted nintedanib: A novel strategy to halt triple‑negative breast cancer via p53‑PPARα/PI3K‑Akt pathway suppression.
Exosomal gene signature in esophageal carcinoma: Insights from single-cell and bulk RNA sequencing.
Endoplasmic Reticulum Stress Is Involved in Prostaglandin F2α-Induced Goat Luteal Cell Apoptosis via the IRE1 Pathway.
Pachymic acid alleviates lipopolysaccharide-induced cystitis glandularis by inhibiting ferroptosis.
Caulerpin suppresses tumor-associated angiogenesis and tumor growth via Hippo signaling in cervical cancer.
Expression Patterns of Deubiquitinating Enzymes in Paclitaxel-Treated Lung Cancer Cells.
Hesperidin Inhibits Oxidative Stress and Apoptosis of Granulosa Cells in Polycystic Ovarian Syndrome Through the JAK2/STAT3 and PI3K/AKT Pathways.
PPM1G promotes chemoresistance in triple negative breast cancer by enhancing YAP signaling.
Protective Effect of Vinegar Powder on (60)Coγ Radiation-Injured Mice and Its Potential Mechanism.
PDCD4 exacerbates myocardial ischemia-reperfusion injury via AKT-mediated apoptosis.
GCN2 promotes fatty acid metabolism through the activation of PI3K/AKT signaling in gastric cancer.
DHCR7 Promotes Liver Metastasis of Pancreatic Cancer Through PI3K-Akt Signaling Pathway.
Hypoglycemic effect and the post-treatment benefits of carrot pulp fermented by Lactobacillus casei NCU215 in type 2 diabetic mice: insights from gut microbiota regulation and restoration of pancreatic islet function.
Fyn inhibition by TAE684: A synergistic strategy to suppress melanoma and reverse vemurafenib resistance.
Tetramethylpyrazine ameliorates 5-fluorouracil-Induced cardiotoxicity by inhibiting PANoptosis and suppressing the p38 MAPK/JNK/ERK signaling pathway.
H(2)S-Activated Theranostic Platform for Precise Photoablation of Colorectal Tumors with NIR-II Dual-Modal Phototherapy.
Combined Schisandrin B and Temozolomide Treatment Induces Mitochondrial Apoptosis in Glioma Cells.
ADRA2A contributes to airway inflammation and apoptosis in asthma through the ERK signaling in vitro and in vivo.
tiRNA: An efficient and controllable gene silencing technology via translation inhibition.
Pharmacological induction of acetyl-CoA carboxylase 1 autophagic degradation attenuates lipid accumulation and cholangiocarcinoma progression.
Eucommia ulmoides Oliver (Duzhong) extract ameliorates cerebral ischemic stroke in mice by remodeling intestinal microbiota and metabolites.
Jianpi Huayu decoction exerts antitumor effects in pancreatic cancer via SCD1-mediated lipid metabolism remodeling/ferroptosis axis.
hnRNP A1 inhibits colorectal cancer tumorigenesis and progression by regulating fatty acid metabolism and RNA stability.
Metformin mitigates cisplatin-induced premature ovarian insufficiency via Sirt1/Nrf2 activation.
Exploring ASPN as a pan-cancer biomarker with a focus on gastric cancer.
Influenza a(H1N1) virus infection impairs syncytiotrophoblast functions by promoting ferroptosis through the TNF-α/ISG15/EGR1 axis.
Knockdown of SUCLG2 inhibits glioblastoma proliferation and promotes apoptosis through LMNA acetylation and the mediation of H4K16la lactylation.
CDC5L facilitates cardiomyocyte proliferation and ameliorates myocardial ischemia-reperfusion injury via modulation of the FGF10-YAP axis.
GABA treatment promoting cell apoptosis in meningioma correlates with EGFR/BCL-2/BAX axis.
WTAP-mediated m(6)A modification of PTPN1 contributes to ulcerative colitis pathogenesis through regulating colonic epithelial cell phenotypes.
Large-scale multi-trait genome-wide analysis for inflammatory bowel disease reveals new insights into its molecular mechanisms and emphasizes the roles of systemic immune regulation.
Absence of astrocytic ceruloplasmin reverses the senescence process with aging of learning and memory abilities.
2-Dodecyl-6-Methoxycyclohexa-2,5-Diene-1,4-Dione from Averrhoa carambola L. roots: Suppressing hepatocellular carcinoma progression through ROS accumulation and p53 pathway-mediated apoptosis.
Daidzein Attenuates Cadmium-Induced Neurotoxicity via Inhibiting Apoptosis and Mitophagy in the Cerebral Cortex of Sprague-Dawley Rats.
Cyclic RGD modified dextran-quercetin polymer micelles for targeted therapy of breast cancer.
Combining photodynamic therapy and ATM inhibition using modified bovine serum albumin: A co-delivery nano platform for eliciting pyroptosis and apoptosis to fuel TNBC therapy.
HKDC1 promotes colorectal cancer progression by regulating RCOR1 expression to activate the Wnt/β-catenin pathway, enhancing proliferation, migration, and epithelial-mesenchymal transition.
ECHS1-NOX4 interaction suppresses rotenone-induced dopaminergic neurotoxicity through inhibition of mitochondrial ROS production.
Formosanin C inhibits triple-negative breast cancer progression by suppressing the phosphorylation of STAT3 and the polarization of M2 macrophages.
Nicotine Ameliorates α-Synuclein Preformed Fibril-Induced Behavioral Deficits and Pathological Features in Mice.
USP51/GRP78/ABCB1 axis confers chemoresistance through decreasing doxorubicin accumulation in triple-negative breast cancer cells.
Bisphenol AF induces cell cycle arrest and apoptosis in TM3 Leydig cells via the p53 signaling pathway.
Trehalose attenuates testicular aging by activating autophagy and improving mitochondrial quality.
LMTK2 and CRB1 are two novel risk genes for Alzheimer's disease in Han Chinese.
Icaritin Represses Autophagy to Promote Colorectal Cancer Cell Apoptosis and Sensitized Low-Temperature Photothermal Therapy via Targeting HSP90-TXNDC9 Interactions.
Transglutaminase 2 nuclear localization enhances glioblastoma radiation resistance.
Effect of periplocin on malignant behavior of oral squamous cell carcinoma cells.
AMH regulates granulosa cell function via ESR2/ p38-MAPK signaling pathway in sheep.
Potential mechanisms by which Jiawei Lianpu Yin inhibits Helicobacter pylori colonization and alleviates gastric mucosal inflammation and damage: Integrated transcriptomics, network pharmacology, and experimental validation.
Overexpression of c-Myc triggers p62 aggregation-mediated mitochondrial mitophagy in cabozantinib resistance of hepatocellular carcinoma.
Effects of venetoclax, a BCL2 inhibitor, in systemic chronic active Epstein-Barr virus disease.
Melatonin ameliorates ischemic brain injury in experimental stroke by regulation of miR-221 and ATG7 axis.
Long non-coding RNA HOXA11-AS inhibits apoptosis, induces proliferation, and promotes autophagy via the miR-214-3p/ATG12 axis in acute T lymphoblastic leukemia.
The oncogenic role of TIMM8A in cancer and the mechanistic insights into the function in breast cancer cells.
Integration of network pharmacology, transcriptomics, and experimental verification to investigate the mechanism of action of cepharanthine hydrochloride against prostate cancer.
Inhibitory Effect and Mechanism of the Down-Regulation of TRIM32 in Colorectal Cancer.
Epigenetic activation of PTEN by valproic acid inhibits PI3K/AKT signaling and Burkitt lymphoma cell growth.
USP14 inhibits mitophagy and promotes tumorigenesis and chemosensitivity through deubiquitinating BAG4 in microsatellite instability-high colorectal cancer.
Anlotinib enhances the efficacy of KRAS-G12C inhibitors through c-Myc/ORC2 axis inhibition in non-small cell lung cancer.
Therapeutic potential of Sweroside in postmenopausal osteoporosis: Inhibition of osteoclast differentiation and promotion of osteoclast apoptosis via NF-κB and MAPK pathways.
TRx0237 induces apoptosis and enhances anti-PD-1 immunotherapeutic efficacy in anaplastic thyroid Cancer.
Structural characterizations and antiaging activities of hydrolyzed low-molecular-weight polysaccharides from Polygoni Multiflori Radix Praeparata.
Research on the functions and potential mechanisms of STAT3 in chronic myelogenous leukemia.
Self-Assembly Oligomeric Anthocyanin-Based Core-Shell Structure of Nanoparticles Enhances the Delivery and Efficacy of Berberine in Osteoarthritis.
Screening Isodon rubescens-Derived Vesicles Harvested at Different Periods as Carriers for the Treatment of Colitis-Associated Cancer.
Liraglutide Inhibits Autophagy to Ameliorate Post-Cardiac Arrest Brain Injury and Ferroptosis in Rats.
Conditional sequential delivery of ginkgetin and rapamycin orchestrates inflammation and autophagy to alleviate intervertebral disc degeneration.
Geraniin attenuates isoproterenol-induced cardiac hypertrophy by inhibiting inflammation, oxidative stress and cellular apoptosis.
Inhibition of microRNA-139-5p by glucagon-like peptide-1 ameliorates oxidative stress-induced vascular endothelial cell damage via targeting SOD1/GCLc.
FABP3 promotes cell apoptosis and oxidative stress by regulating ferroptosis in lens epithelial cells.
Cellular heterogeneity and communication networks in gastric cancer: Single-cell analysis reveals β-hydroxybutyrylation-associated genes and immune infiltration characteristics.
Oleanolic acid improves the in vitro developmental competence of early porcine embryos by reducing oxidative stress and ameliorating mitochondrial function.
Shenmai Injection Reduces Cardiomyocyte Apoptosis Induced by Doxorubicin through miR-30a/Bcl-2.
CD39 Contributes to the Ability of Cell Invasion in Heterogeneity of Colorectal Cancer.
Mild hypothermia (35°C) reduces myocardial ischemia-reperfusion injury and attenuates hypoxia induced apoptosis of H9C2 cardiomyocytes by changing the phosphorylation level of Connexin43 (Cx43) protein.
Aerobic Exercise Affected Lymphocyte Apoptosis by Modulating ROS Release and NLRP3 Inflammasome Activation.
SEPT5 overexpression predicts poor prognosis and promotes progression through feedback regulation of HIF-1α in clear cell renal cell carcinoma.
Microglia-Derived Interleukin-6 Triggers Astrocyte Apoptosis in the Hippocampus and Mediates Depression-Like Behavior.
FABP4 Mediates Inflammation to Regulate Endometrial Epithelial Cell Function During Early Gestation in Sheep.
Oridonin Alleviates Doxorubicin-Induced Cardiotoxicity by Inhibiting p38 MAPK/MMP3 Signaling Pathway.
Cornuside as a promising therapeutic agent for diabetic kidney disease: Targeting regulation of Ca(2+) disorder-mediated renal tubular epithelial cells apoptosis.
Indole-3-Propionic Acid Attenuates Neuroinflammation and Cognitive Deficits by Inhibiting the RAGE-JAK2-STAT3 Signaling Pathway.
The LncRNA lnc-POTEM-4:14 promotes HCC progression by interacting with FOXK1.
Probiotic nanovesicles encapsulating baicalin: a strategy to overcome colorectal cancer.
PTPN23-dependent activation of PI3KC2α is a therapeutic vulnerability of BRAF-mutant cancers.
N-(3-Oxododecanoyl)-Homoserine Lactone Induces Intestinal Barrier Damage in Piglets via the Lipid Raft-Mediated Apoptosis Pathway.
Fatty acid synthase inhibitor cerulenin attenuates glioblastoma progression by reducing EMT and stemness phenotypes, inducing oxidative and ER stress response, and targeting PI3K/AKT/NF-κB axis.
FDX1 overexpression inhibits the growth and metastasis of clear cell renal cell carcinoma by upregulating FMR1 expression.
Resolvin D1 accelerates resolution of neuroinflammation by inhibiting microglia activation through the BDNF/TrkB signaling pathway.
S-nitrosylation of peroxiredoxin 2 exacerbates hyperuricemia-induced renal injury through regulation of mitochondrial homeostasis.
Self-assembled injectable Icariin@ Ti(3)C(2)Tx/doxorubicin hydrogel preserving osteogenesis while synergizing photodynamic and chemodynamic therapy for osteosarcoma.
Tasquinimod promotes the sensitivity of ovarian cancer cells to cisplatin by down-regulating the HDAC4/p21 pathway.
Modification of RNF183 via m6A Methylation Mediates Podocyte Dysfunction in Diabetic Nephropathy by Regulating PKM2 Ubiquitination and Degradation.
Silencing ribosome biogenesis regulator 1 homolog (RRS1) inhibits angiogenesis and cisplatin resistance of lung cancer cells by activating ferroptosis mediated by p53 pathway.
Administration with Yangxinshi ameliorates the progression of atrial fibrillation by affecting atrial remodeling and oxidative stress via the activation of the PI3K/AKT signaling.
Targeting MAD2B as a strategy for ischemic stroke therapy.
CtBP2 Regulates Wnt Signal Through EGR1 to Influence the Proliferation and Apoptosis of DLBCL Cells.
Melatonin ameliorates PM2.5-induced airway inflammation and apoptosis by PERK/eIF2α/ATF4/CHOP in chronic obstructive pulmonary disease mice.
Exogenous hydrogen sulfide improves non-alcoholic fatty liver disease by inhibiting endoplasmic reticulum stress/NLRP3 inflammasome pathway.
Hamayou () protein hydrolysate ameliorates depression by regulating the mitogen-activated protein kinase pathway.
Astaxanthin Alleviates Lung Injury by Regulating Oxidative Stress, Inflammatory Response, P2X7 Receptor, NF-κB, Bcl-2, and Caspase-3 in LPS-Induced Endotoxemia.
SKIL Promotes Pancreatic Cancer Metastasis by Inhibiting TSPYL2 to Activate the TGF-β Pathway.
Conjugated therapy with coaxially printed neural stem cell-laden microfibers and umbilical cord mesenchymal stem cell derived exosomes on complete transactional spinal cord defects.
A pectic polysaccharide from wax gourd peel improves ethanol-induced gastric ulcer injury in mice via the PI3K/AKT signaling pathway.
Ionized Angelica polysaccharides derivatives slow tumor growth in vivo and induce the apoptosis of HepG2 cells via mitochondria death receptor-mediated pathways in vitro.
Environmental responsive dual-drug synergistic and dual-targeted polymer micelles based on chondroitin sulfate for treatment of breast cancer.
Ochratoxin A-induced mitochondrial pathway apoptosis and ferroptosis by promoting glycolysis.
Mechanistic study of Liquiritigenin inhibiting bladder cancer cell proliferation and migration by regulating STING1.
LncRNA SNHG14 Regulated by ZNF460 Promotes Gastric Cancer Progression and Metastasis by Targeting the miR-206/FNDC3A Axis.
Spatial alteration of metabolites in diabetic cortical cataracts: New insight into lactate.
Irisin alleviates steroid-induced vascular dysfunction by regulating the αVβ5-c-Abl-Caveolin-1 signaling pathway.
Resveratrol interrupts Wnt/β-catenin signalling in cervical cancer by activating ten-eleven translocation 5-methylcytosine dioxygenase 1.
Both carvedilol and cimetidine alleviate cisplatin-induced nephrotoxicity via downregulating OCT2.
Fufang-Biejia-Ruangan tablet targeting both cancer-associated fibroblasts and tumor cells by HIPPO-PI3K/AKT cascades in intrahepatic cholangiocarcinoma treatment.
Schisandrin B regulates mitochondrial dynamics via AKT1 activation and mitochondrial targeting to ameliorate renal ischemia-reperfusion injury.
L-Theanine attenuates oxidative damage induced by heat stress through the PI3K/AKT/Nrf2 signaling pathway in skeletal muscle cells.
Acevaltrate overcomes myeloma resistance to bortezomib via pyroptosis by promoting BAX translocalization to mitochondria.
miR-210 Regulates Autophagy Through the AMPK/mTOR Signaling Pathway, Reduces Neuronal Cell Death and Inflammatory Responses, and Enhances Functional Recovery Following Cerebral Hemorrhage in Mice.
Exercise-induced irisin ameliorates cognitive impairment following chronic cerebral hypoperfusion by suppressing neuroinflammation and hippocampal neuronal apoptosis.
Cytohesin-4/ARF6 facilitates the progression of acute myeloid leukemia through activating PIK3R5/PI3K/AKT pathway.
Photothermal Hyperthermia Suppresses Liver Tumor Growth Via Hippo Signaling Pathway-Dependent Inhibition of Cell Proliferation and Induction of Apoptosis.
Halicin Reduces the Warburg Effect and Overcomes Drug Resistance by Activating the Pyruvate Kinase M2 Pathway for Triple-Negative Breast Cancer Treatment.
The miR-21-5p/DUSP8/MAPK signaling pathway mediates inflammation and apoptosis in vascular endothelial cells induced by intermittent hypoxia and contributes to the protective effects of N-acetylcysteine.
Genome-guided discovery of coublibactins from Nocardia coubleae and their gallium complexes with potent antileukemic activity.
Overexpression of the circadian gene Bmal1 regulates the Nrf2/HO-1 oxidative stress pathway to alleviate inflammation and apoptosis in PC12 cells following cerebral ischemia-reperfusion injury.
ATP-responsive tumor targeted lipid nanoparticle for enhanced siRNA delivery and improved treatment efficacy in melanoma.
AMPK-YAP signaling pathway-mediated mitochondrial dynamics and mitophagy participate in the protective effect of silibinin on HaCaT cells under high glucose conditions.
Potential of Ginger Oil to Prevent 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone-Induced Lung Cancer Through Gut Microbiota Modulation and Inflammatory Response Inhibition.
Single-cell RNA sequencing reveals anterograde trans-synaptic degeneration and exacerbated synaptic remodeling in myopia.
Estrogen inhibits hepatocellular carcinoma progression dependent on HOXA11-AS/HOXA11.
Metformin Improves Palmitate-Induced Follicular Granulosa Cell Dysfunction by Activating ULK1-Mediated Autophagy.
Sevoflurane: A dual modulator of miR‑211‑5p and mitochondrial apoptosis in glioma therapy.
Eburicoic acid inhibits endothelial cell pyroptosis and retards the development of atherosclerosis through the Keap1/Nrf2/HO‑1/ROS pathway.
LCMR1 deficiency exacerbates LPS‑induced lung injury in lung‑on‑a‑chip and mouse models.
UCP1 prevents the formation of thoracic aortic aneurysms and dissection by inhibiting the TLR4/NLRP3/IL-1β signaling pathway and VSMC phenotype switching in mice.
Transglutaminase 2 promotes breast cancer cell autophagy by targeting p53/ mTOR axis.
Discovery of a novel BCL-2 inhibitor GW806742X for the treatment of TNBC.
ApTOLL ameliorates cognitive dysfunction and brain injury in ischemic stroke by regulating the miR-335-5p/IRAK1 axis.
Kit-mediated autophagy suppression driven by a viral oncoprotein emerges as a crucial survival mechanism in Merkel cell carcinoma.
Design, synthesis, and antitumor activity of novel thioheterocyclic nucleoside derivatives by suppressing the c-MYC pathway.
Magnesium Lithospermate B Protects Against Ischemic AKI-to-CKD progression via regulating the KLF5/CDK1/Cyclin B1 pathway.
HOXD13 knockdown attenuates apoptosis in prostate cancer via the upregulation of MDM2/p53 signaling.
Isoliensinine Induces Ferroptosis in Urothelial Carcinoma Cells via the PI3K/AKT/HIF-1α Axis: Molecular Evidence from Next-Generation Sequencing.
Neferine induces cell growth inhibition and apoptosis via ROS-mediated activation of p38 in pancreatic ductal adenocarcinoma cells.
EPHX1 enhances drug resistance to regorafenib by activating the JAK/STAT signaling pathway in hepatocellular carcinoma cell lines.
Bovine lactoferrin drives cell cycle arrest and alters the transcriptomic profile of NSCLC cells.
Proteomics analysis reveals FEN1 as a promising therapeutic target against small cell neuroendocrine carcinoma of the cervix.
RhoJ promotes the progression of clear cell renal cell carcinoma via the TNF-α/NF-κB axis.
Demethylzeylasteral suppresses the expression of MESP1 by reducing H3K18la level to inhibit the malignant behaviors of pancreatic cancer.
Development of Antitumor Drugs Targeting c-MYC Pu27 and KRAS G-Quadruplexes.
Buzhong Yiqi decoction improves inflammation and oxidative damage in autoimmune thyroiditis by inhibiting apoptosis via the SIRT1-Mediated Nrf2/NF-κB axis.
Synthetic oleanolic acid derivative, RTA-408, overcome in TMZ-resistant glioblastoma cells by inducing apoptosis and G1 cell cycle arrest.
Identifying the crucial oncogenic mechanisms of DDX56 based on a machine learning-based integration model of RNA-binding proteins.
Copper/calcium co-doped carbon dots for targeted cancer therapy with dual-mode imaging and synergistic induction of cuproptosis and calcium-mediated apoptosis.
Secreted phosphoprotein 1 promotes the activation of keloid fibroblasts via the CD44/TGF-β1/Smad pathway.
Integration of scRNA-seq and bulk tissue RNA-seq data to identify cancer-associated fibroblast-related gene RGMA as a potential treatment target for esophageal cancer.
Tanshinone IIA induces oxidative stress in trophoblast cells and enhances copper dependent death.
Biomimetic cancer cell membrane engineered lipid nanoparticles for enhanced chemotherapy of homologous malignant tumor.
Hsa_circ_0016662 acts as a prognostic biomarker and promotes the progression of hepatocellular carcinoma via autophagy regulation.
Mitochondria-Targeted Microneedles Reverse Doxorubicin Resistance via Apoptosis-Ferroptosis Synergy.
Dehydrocostus lactone suppresses gastric cancer progression by targeting ACLY to inhibit fatty acid synthesis and autophagic flux.
Revitalizing premature ovarian failure: quercetin counteracts imatinib-induced apoptosis via the PI3K/AKT signaling pathway based on network pharmacology.
Indomethacin-encapsulated PLGA nanoparticles improve therapeutic efficacy by increasing apoptosis and reducing motility in glioblastoma cells.
Diagnostic and prognostic potential of FBXO8 expression in kidney renal clear cell carcinoma and its regulation of renal adenocarcinoma cells.
LINC00942 Alleviates NaAsO(2)-induced Apoptosis by Promoting GSH Synthesis Through Targeting miR-214-5p.
Unlocking the potential of LHPP: Inhibiting glioma growth and cell cycle via the MDM2/p53 pathway.
Inhibition of ACSS2 triggers glycolysis inhibition and nuclear translocation to activate SIRT1/ATG5/ATG2B deacetylation axis, promoting autophagy and reducing malignancy and chemoresistance in ovarian cancer.
HSP60 inhibits DF-1 apoptosis through its mitochondrial signal peptide.
Knockdown of integrin β1 inhibits proliferation and promotes apoptosis in bladder cancer cells.
ONC213: a novel strategy to resensitize resistant AML cells to venetoclax through induction of mitochondrial stress.
Gboxin Induced Apoptosis and Ferroptosis of Cervical Cancer Cells by Promoting Autophagy-Mediated Inhibition of Nrf2 Signaling Under Low-Glucose Conditions.
CASP5 associated with PANoptosis promotes tumorigenesis and progression of clear cell renal cell carcinoma.
Ginkgo biloba extract mediates HT22 cell proliferation and migration after oxygen-glucose deprivation/reoxygenation via regulating RhoA-ROCK2 signalling pathway.
Resveratrol Alleviates NEFA-Induced Oxidative Damage in Bovine Mammary Epithelial Cells by Restoring Mitochondrial Function.
Acrylamide Induces Antiapoptotic Autophagy and Apoptosis by Activating PERK Pathway in SH-SY5Y Cells.
Improving Targeted Delivery and Antitumor Efficacy of TRAIL through Fusion with a B7H3-Antagonistic Affibody.
Taraxasterol extracted from Ixeridium gramineum (Fisch.) Tzvel. Attenuated D-GalN/LPS-induced fulminant hepatitis by modulating the JAK/STAT and TNF signalling pathways.
A repeated strike loading organ culture model for studying compression-associated chronic disc degeneration.
Identification of a novel TOP2B::AFF2 fusion gene in B-cell acute lymphoblastic leukemia.
Discovery of a Potent and Selective GSPT1 Molecular Glue Degrader for the Treatment of Castration-Resistant Prostate Cancer.
Extracellular Matrix-Mimicking Hydrogel with Angiogenic and Immunomodulatory Properties Accelerates Healing of Diabetic Wounds by Promoting Autophagy.
Citrinin-Induced Cellular Damage: Insights from SH-SY5Y Cell Line Studies.
Stimulating Soluble Guanylyl Cyclase with the Clinical Agonist Riociguat Restrains the Development and Progression of Castration-Resistant Prostate Cancer.
Quercetin Alleviates Hyperglycemic-Generated Endoplasmic Reticulum Stress-Contacted Apoptosis of Rat Nucleus Pulposus Cells.
Peroxiredoxin 6 maintains mitochondrial homeostasis and promotes tumor progression through ROS/JNK/p38 MAPK signaling pathway in multiple myeloma.
Hypoxia and lipid metabolism related genes drive proliferation migration and immune infiltration mechanisms in colorectal cancer subtyping.
Heat Tolerance-Associated circRNA3685 Regulates Apoptosis and Autophagy in Bovine Mammary Epithelial Cells via Sponging bta-miR-138.
Diisooctyl phthalate (DIOP) exposure leads to cell apoptosis to HUVEC cells and toxicity to Caenorhabditis elegans through increasing the oxidative stress.
Discovery of a potent anticancer agent against pancreatic ductal adenocarcinoma targeting FAK with DFG-out state and JAK/Aurora kinases.
Molecule interacting with CasL-2 enhances tumor progression and alters radiosensitivity in cervical cancer.
Developmental exposure to perfluorooctane sulfonate(PFOS) impairs the endometrial receptivity.
Selenoprotein M protects cardiac endothelial cell integrity against high-glucose stress via enhancing Parkin-mediated mitophagy.
Effects of PPARG on the proliferation, apoptosis, and estrogen secretion in goat granulosa cells.
In vitro and in silico study of the synergistic anticancer effect of alpinumisoflavone with gemcitabine on pancreatic ductal adenocarcinoma through suppression of ribonucleotide reductase subunit-M1.
METTL5 Promotes Tumor Progression in Oral Squamous Cell Carcinoma by Activating the Myc Pathway.
The role of TMEM163 protein in thyroid microcarcinoma: expression pattern and clinical implications.
High-intensity acute noise exposure causes anxiety in female rats by inducing hippocampal neuron apoptosis.
Microplastic exposure induces HSP90α secretion and aggravates asthmatic airway remodeling via PI3K-Akt-mTOR pathway.
oar-miR-411a-5p Promotes Proliferation and Differentiation in Hu Sheep Myoblasts Under Heat Stress by Targeting SMAD2.
The effect and mechanism of atorvastatin regulating PI3K-Akt-mTOR pathway on radiosensitivity of hepatocellular carcinoma cells.
Insulin-like growth factor-1 promotes the testicular sperm production by improving germ cell survival and proliferation in high-fat diet-treated male mice.
In Situ Transformable Nanoparticle Effectively Suppresses Bladder Cancer by Damaging Mitochondria and Blocking Mitochondrial Autophagy Flux.
Integrated multiomics approach and pathological analyses provide new insights into hepatic injury and metabolic alterations in Saanen goats after dietary exposure to aflatoxin B(1).
Design and Synthesis of Novel MEK Inhibitors for the Treatment of Solid Tumors.
Therapeutic effect of dihydroartemisinin on Alzheimer's disease model mice with senile macular degeneration.
ARv7 promotes the escape of prostate cancer cells from androgen deprivation therapy-induced senescence by mediating the SKP2/p27 axis.
The Natural Antherea pernyi Sericin Protein Suppresses Gastric Cancer Formation by Inhibiting Cell Proliferation and Inducing Cell Apoptosis.
Trillin inhibits MAP3K11/NF-κB/COX-2 signaling pathways through upregulation of miR-145-5p in castration-resistant prostate cancer.
Anti-osteosarcoma activity of Corynoline via Src/JNK signaling-mediated cell cycle arrest and mitochondrial apoptosis.
Huqi formula suppresses hepatocellular carcinoma growth by modulating the PI3K/AKT/mTOR pathway and promoting T cell infiltration.
Metformin inhibits the growth of SCLC cells by inducing autophagy and apoptosis via the suppression of EGFR and AKT signalling.
Dihydroartemisinin inhibits EphA2/PI3K/Akt pathway-mediated malignant behaviors and vasculogenic mimicry in glioma stem cells.
Periplaneta americana Extract Protects Glutamate-Induced Nerve Cell Damage by Inhibiting N-Methyl-D-Aspartate Receptor Activation.
Bisdemethoxycurcumin and Curcumin Alleviate Inflammatory Bowel Disease by Maintaining Intestinal Epithelial Integrity and Regulating Gut Microbiota in Mice.
Inhibition Effects and Mechanism Study of rAj-HRP30, a Recombinant Histidine-Rich Peptide from Apostichopus japonicus, on the Viability of Pancreatic Ductal Adenocarcinoma Cells Panc01 and Panc02.
Multi-omics analysis reveals the impact of YAP/TEAD4-mediated EIF5A1 expression on mitochondrial apoptosis and bladder cancer progression.
Berberine attenuates obesity-induced skeletal muscle atrophy via regulation of FUNDC1 in skeletal muscle of mice.
Cadmium-Induced Kidney Apoptosis Based on the IRE1α-XBP1 Signaling Pathway and the Protective Effect of Quercetin.
Low shear stress induces vascular endothelial cells apoptosis via miR-330 /SOD2 /HSP70 signaling pathway.
Simultaneously delivery of functional gallium ions and hydrogen sulfide to endow potentiated treatment efficacy in chemo- and PARPi-resistant ovarian cancer.
Plasma-activated solutions prevent peritoneal adhesion formation by regulating eNOS expression in mesothelial cells.
Cancer-associated fibroblast-derived extracellular vesicles regulate lipophagy through PLIN2 to modulate dormancy in salivary gland adenoid cystic carcinoma cells.
Corticotropin-releasing hormone inhibits autophagy by suppressing PTEN to promote apoptosis in dermal papilla cells.
Unraveling the miR-144-3p/PUMA pathway: a novel regulator of FDX1-mediated cuproptosis in colorectal cancer.
TM4SF1 as a Prognostic Biomarker and Therapeutic Target in Cervical Cancer.
Design, synthesis, and bioevaluation of pyrazole-containing tubulin polymerisation inhibitors based on conformational constraint strategy.
Pan-cancer analysis identifies adhesion G protein-coupled receptor G6 as a potential prognostic and immunotherapeutic biomarker with its functional validation.
Bovine tubulin cofactor D (TBCD) disrupts tubulin dimers and inhibits tumor growth via the TNF-α signaling pathways-mediated ROS production.
CD44 and αV-integrins dual-targeting bimetallic nanozymes for lung adenocarcinoma therapy via NIR-enhanced ferroptosis/apoptosis.
The novel thioredoxin reductase inhibitor butaselen suppresses lung cancer by inducing oxidative stress.
Flavonoids from Polypodium hastatum as neuroprotective agents attenuate cerebral ischemia/reperfusion injury in vitro and in vivo via activating Nrf2.
Knockdown of NDUFAF6 inhibits breast cancer progression via promoting mitophagy and apoptosis.
Juglone targets MMP-1 to inhibit gastric cancer progression.
Appropriate doses of ionizing radiation facilitate the proliferation and anti-tumor effects of γδ T cells through ERK and p38MAPK pathways in vitro.
YAP regulates the hypertrophy and apoptosis of antler chondrocytes through maintaining calcium homeostasis and mitochondrial function.
Puerarin alleviates liver injury induced by heat-stress through regulating oxidative stress and apoptosis in broilers.
Skullcapflavone II Inhibits SLC1A4-Mediated L-Serine Uptake and Promotes Mitochondrial Damage in Gastric Cancer.
Kaempferol exerts anti-colorectal cancer effects through its multi-target mediated glucose metabolism remodeling.
Neuroprotective peptide OL-FS13 attenuates cardiac apoptosis and myocardial infarction injury through Nrf2/HO-1 pathway.
RSL3 Mitigates Doxorubicin Resistance in Breast Cancer via Targeted Disruption of Glycolytic Flux.
Albiflorin enhances the antitumor effects of propofol in hepatocellular carcinoma cells by inhibiting the Wnt/β-catenin signaling activation.
Erzhi Tiangui formula increases the number of high-quality blastocysts in patients with advanced age by regulating the Nrf2/HO-1 signaling pathway: a randomized controlled study.
The Role of Chaf1b in Maintaining Glioma Stem Cell Stemness and Regulating Microglial Polarization.
TRIM47-facilitated PLK1 stabilization promotes the proliferation of liver cancer cells.
Hypoxic preconditioned mesenchymal stem cell-derived exosomes alleviate oxidative stress-induced cardiomyocyte apoptosis through miR-486-5p.
Cyclophilin D suppresses colorectal cancer progression through the activation of an autophagy-mediated apoptotic pathway.
Shikonin inhibits multiple tumor malignant phenotypes and is associated with Hedgehog pathway downregulation in lung adenocarcinoma.
RNF152-mediated, ubiquitin-dependent degradation of HSP27 activates the PI3K/AKT pathway, driving synovial inflammatory cascades in TMJOA.
A Scorpion Peptide Exerts Selective Anti-Leukemia Effects Through Disrupting Cell Membranes and Triggering Bax/Bcl-2-Related Apoptosis Pathway.
Hedyotis diffusae herba -Scutellaria Barbata herba drug pair suppresses prostate cancer by inducing apoptosis.
Triptolide combined with arsenic trioxide induces apoptosis of myelodysplastic syndrome cells by inhibiting the NF-κB signaling pathway.
Resveratrol Derivatives with a Urea Backbone Exert Anticancer Effects against Liver Cancer via Apoptosis Induction and Metastasis Inhibition.
NSUN2 Negatively Regulates TP53 mRNA Stability to Promote the Malignant Progression of Nasopharyngeal Carcinoma.
CD36-mediated fatty acid metabolic reprogramming activates synovial fibroblasts and promotes rheumatoid arthritis progression.
Liproxstatin-1 Protects SH-SY5Y Cells by Inhibiting H(2)O(2)-Induced Excessive Mitophagy and Apoptosis.
Epimedokoreanin B blocks autophagic flux to inhibit progression of triple negative breast cancer through targeting MCOLN1/TRPML1 channel.
Gamma-aminobutyric acid-B receptor axis promotes proliferation and survival of multiple myeloma cells via enhancing ERK1/2 activity.
Mechanism of lncRNA WARS2-IT1 promoting angiogenesis of glioma through miR-299-3P/VEGFA axis and activating PI3K/AKT signaling pathway.
Integrated stress response activation induced by usnic acid alleviates BCL-2 inhibitor ABT-199 resistance in acute myeloid leukemia.
cPDS Promotes Cell Apoptosis by Reducing the Translational Efficiency of BIRC3 mRNA in HCC.
P5CS deacetylation mediated by SIRT2 facilitates tumor growth by enhancing mitochondrial respiration in hepatocellular carcinoma.
Dominant follicle-targeted nanocarriers for GH delivery to alleviate premature ovarian insufficiency.
A novel variant in the MAP3K1 genomic locus reveals abnormal cell apoptosis as a potential pathogenic mechanism in 46, XY disorders of sex development.
circGAPVD1 inhibits the progression of gastric cancer through miR-4424/STK4 axis and encoding GAPVD1-137aa protein.
Zn(2+)-driven metformin conjugated with siRNA attenuates osteoarthritis progression by inhibiting NF-κB signaling and activating autophagy.
Silencing PIM1 inhibits ENO1-induced AKT activation and attenuates fibrillogenesis during spinal cord injury-induced skeletal muscle atrophy.
Melatonin Synergises the Chemotherapeutic Effect of Temozolomide in Glioblastoma by Suppressing NF-κB/COX-2 Signalling Pathways.
TNFSF14-HVEM/LTβR Exacerbates Keratinocyte Abnormalities and IMQ-Induced Psoriatic Skin Inflammation via Activating NF-κB/TWIST1 Signalling Pathway.
PIMREG modulation of PI3K/Akt pathway enhances sorafenib resistance in Huh7 cells.
miR-128-3p Reduces Proliferation and Immune Escape in Acute Myeloid Leukemia Through Targeted Regulation of ZEB1.
Mechanism of sulforaphane in treatment of pancreatic cancer cell based on network pharmacology and in vitro experiments.
Gracillin induces mitochondria-mediated apoptosis on pancreatic ductal adenocarcinoma through disruption of redox homeostasis via inhibiting NRF2/HO-1 antioxidant axis.
Inhibitory effect of SMAD2 on myogenesis in heat-stressed Hu sheep myoblasts.
Lobaric Acid Exhibits Anticancer Potential by Modulating the Wnt/β-Catenin Signaling Pathway in MCF-7 Cells.
Melatonin mitigates arsenic and fluoride-induced cardiotoxicity in chickens by maintaining mitochondrial homeostasis.
The functional role of exosomal miRNA-675-3p derived from patients with hepatocellular carcinoma.
Non-SMC condensin I complex subunit H promotes cell proliferation and inhibits cell apoptosis of clear cell renal cell carcinoma by activating the PI3K/AKT pathway.
TRIM2 inhibits apoptosis by ubiquitinating BNIP3 to protect the intestine against ischemia-reperfusion injury in mice.
Integrated network pharmacology and metabolomics to explore the mechanism of Kadsura coccinea root in alleviating acetaminophen-induced liver injury.
Mechanisms and synergistic effects of the active components of Xanthocerais lignum in inhibiting rheumatoid arthritis through the modulation of the biological behavior of synovial cells.
TGF-β-Enriched Exosomes from Acute Myeloid Leukemia Activate Smad2/3-MMP2 and ERK1/2 Signaling to Promote Leukemic Cell Proliferation, Migration, and Immune Modulation.
Vinburnine potentiates anti-PD1 immunotherapy in melanoma through IL-24 secretion via P38/MAPK/ATF3 signaling.
The study of JAZF1-mediated apoptosis of decidual stromal cells by activating the NF-κB signaling pathway in spontaneous preterm birth.
Spautin-1 inhibits the growth of diffuse large B-cell lymphoma by inducing mitochondrial damage-mediated PANoptosis and anti-tumor immunity.
PP2A attenuates α-amanitin-induced liver injury by promoting autophagy and inhibiting apoptosis in mouse models.
MRPL13 enhances mitochondrial function and promotes tumor progression in ovarian cancer by inhibiting mPTP opening via SLC25A6.
Isorhamnetin protects against D-GalN/LPS-induced acute liver injury in mice through anti-oxidative stress, anti-inflammation, and anti-apoptosis.
Targeting ATF4-DDIT4/TXNIP induced mitochondrial dysfunction and ferroptosis: ISRIB as novel therapy for septic cardiomyopathy.
Oxypalmatine promotes apoptosis and protective autophagy in lung cancer cells via the PI3K/AKT pathway.
Development of Hydrogen Sulfide-Donating Silybin Derivatives with a Type-2 Diabetes Mellitus-Alleviating Effect through Improving Intestinal L-Cell Functions.
Indoleamine 2,3-dioxygenase can improve ovarian function in premature ovarian insufficiency via aromatic hydrocarbon receptor and regulatory T cells†.
Exploring the Antitumor Mechanisms of Bai-Hua-She-She-Cao and Ban-Zhi-Lian against Head and Neck Squamous Cell Carcinoma: A Study on Natural Anticancer Therapeutics.
MLCK inhibition induces synthetic lethality in MYC-driven cancer.
PCSK9 exacerbates sevoflurane-induced neuroinflammatory response and apoptosis by up-regulating cGAS-STING signal.
Klotho improves Der p1-induced bronchial epithelial cell damage by inhibiting endoplasmic reticulum stress to regulate mitochondrial function.
Synergistic photoinduction of ferroptosis and apoptosis by a mitochondria-targeted iridium complex for bladder cancer therapy.
Porcine epidemic diarrhea virus nsp14 inhibited IFN-Ⅰ production by targeting RIG-I for degradation.
EGFR tyrosine kinase inhibitor ZZC4 overcomes acquired resistance to gefitinib.
Low molecular weight heparins promote migration and invasion of trophoblast cells through regulating the PI3K/AKT signaling pathway.
Paeoniflorin-mediated downregulation of VEGFA: unveiling the therapeutic mechanism of buyang huanwu decoction in diabetic retinopathy.
Oxidized Low-Density Lipoprotein Decreases the Survival of Bone Marrow Stem Cells via Inhibition of Bcl-2 Expression.
Cinobufacini Inhibits Survival and Metastasis of Hepatocellular Carcinoma via c-Met Signaling Pathway.
Bionic nanovesicles sequentially treat flaps with different durations of ischemia by thrombolysis and prevention of ischemia-reperfusion injury.
Hepatoprotective effects of polysaccharide from Morchella esculenta are associated with activation of the AMPK/Sirt1 signaling pathway in mice with NAFLD.
Molecular mechanisms of antiproliferative and pro-apoptotic effects of essential oil active constituents in MCF7 and T24 cancer cell lines: in vitro insights and in silico modelling of proapoptotic gene product-compound interactions.
Carboxymethyl polysaccharides from Poria cocos (Schw.) wolf: Structure, immunomodulatory, anti-inflammatory, tumor cell proliferation inhibition and antioxidant activity.
Chlorogenic acid improves SPS-induced PTSD-like behaviors in rats by regulating the crosstalk between Nrf2 and NF-κB signaling pathway.
Design, synthesis and antitumor activity evaluation of novel modified 18β-glycyrrhetinate derivatives as PPARγ agonists.
Palmatine activation of TFEB enhances autophagy and alleviates endoplasmic reticulum stress in intervertebral disc degeneration.
Huaiqihuang (HQH) protects podocytes from high glucose-induced apoptosis and inflammation response by regulating PI3K/AKT/mTOR pathway.
Dexmedetomidine Promotes Angiogenesis After Ischemic Stroke Through the NRF2/HO-1/VEGF Pathway.
Early secretory antigen target of 6-kDa of Mycobacterium tuberculosis inhibits macrophage apoptosis and host defense via TLR2.
The highly expressed GOLPH3 in colorectal cancer cells activates smoothened to drive glycolysis and promote cancer cell growth and radiotherapy resistance.
The IL-6 autocrine loop promoting IFN-γ-induced fibroblast senescence is involved in psychological stress-mediated exacerbation of vitiligo.
KIF2C promotes oral squamous cell carcinoma progression via PLK1 upregulation: implications for biomarker development and therapeutic targeting.
The cardioprotective effects of acteoside in myocardial ischemia reperfusion injury and the underlying mechanism.
PCSK9 Targeted Autophagosome-Tethering Compounds: Design, Synthesis, and Antiatherosclerosis Evaluation.
SAP30 promotes clear cell renal cell carcinoma proliferation and inhibits apoptosis through the MT1G axis.
Dl-3-n-butylphthalide ameliorates diabetic foot ulcer by inhibiting apoptosis and promoting angiogenesis.
Analysis and identification of PTBP2 as an oncogene in hepatocellular carcinoma.
Tannic acid‑cerium nanoenzymes serve as broad-spectrum antioxidants to alleviate acute kidney injury by modulating macrophage polarization, mitophagy and endoplasmic reticulum stress.
Aggregation-Induced Emission-Active Photosensitizer-Mediated Photodynamic Therapy for Anti-Psoriasis.
ITGB1 Alleviates High Glucose-Induced Myocardial Cell Injury by Inhibiting Endoplasmic Reticulum Stress and Cell Apoptosis.
Sodium Tanshinone IIA Sulfonate Protects Primary Cardiomyocytes Against Radiation-Induced Myocardial Injury via the p38 Pathway.
Long non-coding RNA HOTAIR promotes tumourigenesis by affecting proliferation, invasion, migration, and apoptosis of liver cancer cells.
Mitofusin 2 inhibits high glucose-induced apoptosis of human lens epithelial cells via modulating mitochondrial function and autophagy.
Ginsenoside Rg2 Attenuates Aging-Induced Liver Injury via Inhibiting Caspase 8-Mediated Pyroptosis, Apoptosis and Modulating Gut Microbiota.
Lobetyolin Suppresses the Proliferation of Hepatocellular Carcinoma through Activating DUSP1-ERK1/2 Signaling Pathway.
Isoflurane preconditioning protects against renal ischemia/reperfusion injury in diabetes via activation of the Brg1/Nrf2/HO-1 signaling pathway.
Metformin alleviates bevacizumab-induced vascular endothelial injury in mice through growth differentiation factor 15 upregulation.
Catalpol alleviates amyloid- generation and neuronal oxidative stress injury via activating the Keap1-Nrf2/ARE signaling pathway in the immortalized lymphocytes from patients with late-onset Alzheimer's disease and SKNMC cells co-culture model.
Shock Wave Therapy Alleviates Hypoxia/Reoxygenation-Induced Cardiomyocyte Injury by Inhibiting Both Apoptosis and Ferroptosis.
Dissection of Targeting Molecular Mechanisms of Celastrol-induced Nephrotoxicity via A Combined Deconvolution Strategy of Chemoproteomics and Metabolomics.
lncRNA GAPLINC regulates vascular endothelial cell apoptosis in atherosclerosis.
Therapeutic potential of salidroside in type I diabetic erectile dysfunction: Attenuation of oxidative stress and apoptosis via the Nrf2/HO-1 pathway.
Exploring the effects of hypoxia and reoxygenation time on hepatocyte apoptosis and inflammation.
Mitochondrial Targeted Cerium Oxide Nanoclusters for Radiation Protection and Promoting Hematopoiesis.
Anti-Cancer Potency of Copper-Doped Carbon Quantum Dots Against Breast Cancer Progression.
Polyoxometalates Ameliorate Metabolic Dysfunction-Associated Steatotic Liver Disease by Activating the AMPK Signaling Pathway.
Morphological and functional observations of a novel model of retinal ischemia injury induced by bilateral carotid artery stenosis in mice.
Integrating network pharmacology with experimental validation to investigate the mechanism of Wuwei Zishen formula in improving perimenopausal syndrome.
PHGDH is Key to a Prognostic Multigene Signature and a Potential Therapeutic Target in Acute Myeloid Leukemia.
KYNU Expression Promotes Cisplatin Resistance in Esophageal Cancer.
Pan-Cancer Analysis of PGAM1 and Its Experimental Validation in Uveal Melanoma Progression.
The chiisanoside derivatives present in the leaves of Acanthopanax sessiliflorus activate autophagy through the LRP6/GSK3β axis and thereafter inhibit oxidative stress, thereby counteracting cisplatin-induced ototoxicity.
Targeting autophagy: polydatin's role in inducing cell death in AML.
Inhibition of NNMT enhances drug sensitivity in lung cancer cells through mediation of autophagy.
Multidimensional role of adapalene in regulating cell death in multiple myeloma.
B4 suppresses lymphoma progression by inhibiting fibroblast growth factor binding protein 1 through intrinsic apoptosis.
The therapeutic mechanism of Compound Lurong Jiangu Capsule for the treatment of cadmium-induced osteoporosis: network pharmacology and experimental verification.
Neoadjuvant immunotherapy plus chemotherapy for squamous cell carcinoma of the paranasal sinus: a case report.
Histone deacetylase 3-specific inhibitor RGFP966 attenuates oxidative stress and inflammation after traumatic brain injury by activating the Nrf2 pathway.
Activating autophagy promotes skin regeneration induced by mechanical stretch during tissue expansion.
New molecular mechanisms of quercetin in improving recurrent spontaneous abortion based on in-depth network pharmacology and molecular docking.
ACSS2 enables melanoma cell survival and tumor metastasis by negatively regulating the Hippo pathway.
Listeria monocytogenes: possible mechanism of infection of goat uterus and its effects on uterine autophagy and cell apoptosis.
Low-Dose LPS Modulates Microglia/Macrophages Phenotypic Transformation to Amplify Rehabilitation Effects in Chronic Spinal Cord Injured (CSCI) Mice.
HSP70 protects PC12 cells against TBHP-induced apoptosis and oxidative stress by activating the Nrf2/HO-1 signaling pathway.
ESF1 positively regulates MDM2 and promotes tumorigenesis.
UFL1 regulates cellular homeostasis by targeting endoplasmic reticulum and mitochondria in NEFA-stimulated bovine mammary epithelial cells via the IRE1α/XBP1 pathway.
Pyrimidine compounds BY4003 and BY4008 inhibit glioblastoma cells growth via modulating JAK3/STAT3 signaling pathway.
Enhanced glioma cell death with ZnO nanorod flowers and temozolomide combination therapy through autophagy and mitophagy pathways.
Combining the novel FLT3 and MERTK dual inhibitor MRX-2843 with venetoclax results in promising antileukemic activity against FLT3-ITD AML.
Catalpol alleviates heat stroke-induced liver injury in mice by downregulating the JAK/STAT signaling pathway.
Identification of Matrine as a Kirsten rats Arcomaviral oncogene homolog inhibitor alleviating chemotherapy-induced neuropathic pain.
Quercetin ameliorates oxidative stress-induced apoptosis of granulosa cells in dairy cow follicular cysts by activating autophagy via the SIRT1/ROS/AMPK signaling pathway.
LncRNA OIP5-AS1 regulates ferroptosis and mitochondrial dysfunction-mediated apoptosis in spinal cord injury by targeting the miR-128-3p/Nrf2 axis.
Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain ischemic stroke by suppressing ARF1 lactylation.
Palliative effect of rotating magnetic field on glucocorticoid-induced osteonecrosis of the femoral head in rats by regulating osteoblast differentiation.
Da-Chai-Hu-Tang Formula inhibits the progression and metastasis in HepG2 cells through modulation of the PI3K/AKT/STAT3-induced cell cycle arrest and apoptosis.
A New Class of Gold(I) NHC Complexes with Proapoptotic and Resensitizing Properties towards Multidrug Resistant Leukemia Cells Overexpressing BCL-2.
DMDD, isolated from Averrhoa carambola L., ameliorates diabetic nephropathy by regulating endoplasmic reticulum stress-autophagy crosstalk.
Gastrodin Alleviates Angiotensin II-Induced Hypertension and Myocardial Apoptosis via Inhibition of the PRDX2/p53 Pathway In Vivo and In Vitro.
CCDC113 promotes colorectal cancer tumorigenesis and metastasis via TGF-β signaling pathway.
SS-31 mitigates oxidative stress and restores mitochondrial function in cigarette smoke-damaged oral epithelial cells via PINK1-mediated mitophagy.
Roles of m(6)A modification in regulating PPER pathway in cadmium-induced pancreatic β cell death.
Placental growth factor alleviates hyperglycemia-induced trophoblast pyroptosis by regulating mitophagy.
Groenlandicine enhances cisplatin sensitivity in cisplatin-resistant osteosarcoma cells through the BAX/Bcl-2/Caspase-9/Caspase-3 pathway.
Emodin induces ferroptosis in colorectal cancer through NCOA4-mediated ferritinophagy and NF-κb pathway inactivation.
Semi-synthesis and in vitro anti-cancer effects evaluation of novel xanthohumol derivatives.
Lenvatinib acts on platelet‑derived growth factor receptor β to suppress the malignant behaviors of gastric cancer cells.
Prebiotic stachyose inhibits PRDX5 activity and castration-resistant prostate cancer development.
Investigation on the mechanism of androsta-4,6,8,14-tetraene-3,11,16-trione against acute lymphoblastic leukemia.
Panobinostat sensitizes AraC-resistant AML cells to the combination of azacitidine and venetoclax.
Procyanidine alleviates bisphenol A-induced apoptosis in TM3 cells via the Nrf2 signaling pathway.
SFRP4 contributes to insulin resistance-induced polycystic ovary syndrome by triggering ovarian granulosa cell hyperandrogenism and apoptosis through the nuclear β-catenin/IL-6 signaling axis.
Effects of exogenous hydrogen sulfide and honokiol intervention on the proliferation, apoptosis, and calcium signaling pathway of rat enteric glial cells.
Modified EBP-bFGF targeting endogenous renal extracellular matrix protects against renal ischemia-reperfusion injury in rats.
N-Acetylcysteine assists muscle development in offspring of mice subjected to maternal heat stress during pregnancy.
Effect of dapagliflozin on pulmonary vascular remodeling in rats with chronic hypoxic pulmonary arterial hypertension.
Inhibition of HOXC11 by artesunate induces ferroptosis and suppresses ovarian cancer progression through transcriptional regulation of the PROM2/PI3K/AKT pathway.
Siwu decoction exerts a phytoestrogenic osteoprotective effect on postmenopausal osteoporosis via the estrogen receptor/phosphatidylinositol 3-kinase/serine/threonine protein kinase pathway.
PYGL regulation of glycolysis and apoptosis in glioma cells under hypoxic conditions via HIF1α-dependent mechanisms.
Mutation of Pseudomonas aeruginosa lasI/rhlI diminishes its cytotoxicity, oxidative stress, inflammation, and apoptosis on THP-1 macrophages.
HIV Protein Nef Induces Cardiomyopathy Through Induction of Bcl2 and p21.
[Aumolertinib combined with anlotinib inhibits proliferation of non-small cell lung cancer cells by down-regulating the PI3K/AKT pathway].
Targeting NUF2 suppresses gastric cancer progression through G2/M phase arrest and apoptosis induction.
Regorafenib promotes antitumor progression in melanoma by reducing RRM2.
Overexpression of USP35 enhances the protective effect of hUC-MSCs and their extracellular vesicles in oxygen-glucose deprivation/reperfusion-induced SH-SY5Y cells via stabilizing FUNDC1.
Loss of NAT10 Reduces the Translation of Kmt5a mRNA Through ac4C Modification in Cardiomyocytes and Induces Heart Failure.
LncRNA Pvt1 aggravates cardiomyocyte apoptosis via the microRNA-216/Ccnd3 axis.
A quinoline-2-thione derivative as a novel chemotherapy drug candidate displays anti-tumor activity in vitro and in vivo.
Lipoxin A4 modulates the PKA/CREB and NF-κB signaling pathway to mitigate chondrocyte catabolism and apoptosis in temporomandibular joint osteoarthritis.
Donafenib inhibits PARP1 expression and induces DNA damage, in combination with PARP1 inhibitors promotes apoptosis in liver cancer cells.
Apoptosis mediated by crosstalk between mitochondria and endoplasmic reticulum: A possible cause of citrinin disruption of the intestinal barrier.
Prenatal exposure to dibutyl phthalate contributes to erectile dysfunction in offspring male rats by activating the RhoA/ROCK signalling pathway.
Partial reduction of interleukin-33 signaling improves senescence and renal injury in diabetic nephropathy.
Sappanone A ameliorates acute lung injury through inhibiting the activation of the NF-κB signaling pathway.
Acrylamide Exposure Impairs Ovarian Tricarboxylic Acid Cycle and Reduces Oocyte Quality in Mouse.
E3 ubiquitin ligase TRIM31 alleviates dopaminergic neurodegeneration by promoting proteasomal degradation of VDAC1 in Parkinson's Disease model.
Rapamycin alleviates irradiation-induced parotid injury by enhancing the whole gland homeostasis.
Ciclopirox platinum(IV) conjugates suppress tumors by promoting mitophagy and provoking immune responses.
Gut microbiota-driven metabolic alterations reveal the distinct pathogenicity of chemotherapy-induced cachexia in gastric cancer.
Verapamil attenuates myocardial ischemia/reperfusion injury by inhibiting apoptosis via activating the JAK2/STAT3 signaling pathway.
Modulating autophagy to boost the antitumor efficacy of TROP2-directed antibody-drug conjugate in pancreatic cancer.
Dual-targeted halofuginone hydrobromide nanocomplexes for promotion of macrophage repolarization and apoptosis of rheumatoid arthritis fibroblast-like synoviocytes in adjuvant-induced arthritis in rats.
CaMKII Exacerbates Doxorubicin-Induced Cardiotoxicity by Promoting Ubiquitination Through USP10 Inhibition.
Efficient, High-Quality Engineering of Therapeutic Extracellular Vesicles on an Integrated Nanoplatform.
Hyperoside induces ferroptosis in chronic myeloid leukemia cells by targeting NRF2.
Effect and underlying mechanism of a photochemotherapy dual-function nanodrug delivery system for head and neck squamous cell carcinoma.
αKlotho modulates BNIP3-mediated mitophagy by regulating FoxO3 to decrease mitochondrial ROS and apoptosis in contrast-induced acute kidney injury.
Acrolein exposure affects ovarian function by interfering with glycolysis and mitochondrial energy metabolism in mouse.
Inhibition of the FOXO1-ROCK1 axis mitigates cardiomyocyte injury under chronic hypoxia in Tetralogy of Fallot by maintaining mitochondrial quality control.
Pesticide metabolite 3, 5, 6-trichloro-2-pyridinol causes massive damage to the cochlea resulting in hearing loss in adult mice.
L-Glutamine Substantially Improves 5-Fluorouracil-Induced Intestinal Mucositis by Modulating Gut Microbiota and Maintaining the Integrity of the Gut Barrier in Mice.
Chlorogenic acid improves the development of porcine parthenogenetic embryos by regulating oxidative stress and ameliorating mitochondrial function.
Synergistic anticancer effects of ginsenoside CK and gefitinib against gefitinib-resistant NSCLC by regulating the balance of angiogenic factors through HIF-1α/VEGF.
LRP8 promotes tumorigenesis in ovarian cancer through inhibiting p53 signaling.
Joint Analysis of Genome-wide DNA Methylation and Transcription Sequencing Identifies the Role of BAX Gene in Heat Stress-Induced-Sertoli Cells Apoptosis.
Food therapy of scutellarein ameliorates pirarubicin‑induced cardiotoxicity in rats by inhibiting apoptosis and ferroptosis through regulation of NOX2‑induced oxidative stress.
Prognostic and immunotherapeutic implications of bilirubin metabolism-associated genes in lung adenocarcinoma.
Glucose-modified BSA/procyanidin C1 NPs penetrate the blood-brain barrier and alleviate neuroinflammation in Alzheimer's disease models.
Heme oxygenase 1 (HO1) regulates autophagy and apoptosis via the PI3K/AKT/mTOR signaling pathway of yak Sertoli cells.
Unveiling the mechanisms of trichloroethylene hypersensitivity syndrome: Exploring the role of connexin 43 gap junctions in severe skin damage.
Identification of MACC1 as a potential biomarker for pulmonary arterial hypertension based on bioinformatics and machine learning.
Dachengqi decoction ameliorates sepsis-induced liver injury by inhibiting the TGF-β1/Smad3 pathways.
Non-oxidized and oxidized flaxseed orbitides differently induce HepG2 cell apoptosis: involvement of cellular uptake and membrane death receptor DR4.
Naringenin reduces oxidative stress and necroptosis, apoptosis, and pyroptosis in random-pattern skin flaps by enhancing autophagy.
Molecular, biological characterization and drug sensitivity of chidamide-resistant MCF7 cells.
Endometrial stem cell-derived exosomes repair cisplatin-induced premature ovarian failure via Hippo signaling pathway.
miR-92b-3p protects retinal tissues against DNA damage and apoptosis by targeting BTG2 in experimental myopia.
Circ_0001671 regulates prostate cancer progression through miR-27b-3p/BLM axis.
miR-1202 regulates BPH-1 cell proliferation, apoptosis, and epithelial-to-mesenchymal transition through targeting HMGCL.
miR-122-5p Promotes Cowshed Particulate Matter2.5-Induced Apoptosis in NR8383 by Targeting COL4A1.
Salvianolic acid A alleviates H(2)O(2)-induced endothelial oxidative injury via miR-204-5p.
IDH1 mutation produces R-2-hydroxyglutarate (R-2HG) and induces mir-182-5p expression to regulate cell cycle and tumor formation in glioma.
Curdepsidone A Induces Intrinsic Apoptosis and Inhibits Protective Autophagy via the ROS/PI3K/AKT Signaling Pathway in HeLa Cells.
The Effects of Resveratrol and Apigenin on Jejunal Oxidative Injury in Ducks and on Immortalized Duck Intestinal Epithelial Cells Exposed to H(2)O(2).
FGF17 protects cerebral ischemia reperfusion-induced blood-brain barrier disruption via FGF receptor 3-mediated PI3K/AKT signaling pathway.
Knockdown of trem2 promotes proinflammatory microglia and inhibits glioma progression via the JAK2/STAT3 and NF-κB pathways.
Synergistic Effect of Flavonoids and Metformin on Protection of the Methylglyoxal-Induced Damage in PC-12 Neuroblastoma Cells: Structure-Activity Relationship and Potential Target.
Mechanistic exploration and experimental validation of the Xiaochaihu decoction for the treatment of breast cancer by network pharmacology.
Withanolides from the active extract of Physalis angulate and their anti-hepatic fibrosis effects.
Pan-cancer analysis of LRRC59 with a focus on prognostic and immunological roles in hepatocellular carcinoma.
Cytotoxic withanolides from the stems and leaves of Physalis ixocarpa.
Augmented drug resistance of osteosarcoma cells within decalcified bone matrix scaffold: The role of glutamine metabolism.
Upregulation of tumor suppressor PIAS3 by Honokiol promotes tumor cell apoptosis via selective inhibition of STAT3 tyrosine 705 phosphorylation.
Lrg1 silencing attenuates ischemia-reperfusion renal injury by regulating autophagy and apoptosis through the TGFβ1- Smad1/5 signaling pathway.
Mammalian STE20-like kinase 1 inhibits synoviocytes activation in rheumatoid arthritis through mitochondrial dysfunction mediated by SIRT3/mTOR axis.
Akt/mTOR Pathway Agonist SC79 Inhibits Autophagy and Apoptosis of Oligodendrocyte Precursor Cells Associated with Neonatal White Matter Dysplasia.
Alginate microspheres encapsulating hox transcript antisense RNA siRNA regulate the Hedgehog-Gli1 pathway to alleviate epidermal growth factor receptor tyrosine kinase inhibitors resistance.
Muscone alleviates neuronal injury via increasing stress granules formation and reducing apoptosis in acute ischemic stroke.
SOD2 confers anlotinib resistance via regulation of mitochondrial damage in OSCC.
Homoharringtonine induces apoptosis of mammary carcinoma cells by inhibiting the AKT/mTOR signaling pathway.
Golden bifid treatment regulates gut microbiota and serum metabolites to improve myocardial dysfunction in cecal ligation and puncture-induced sepsis mice.
SETDB1-mediated CD147-K71 di-methylation promotes cell apoptosis in non-small cell lung cancer.
Research Note: Preliminary functional analysis of EGF-like domains of Eimeria tenella microneme protein 7 identified in sporozoites and merozoites.
Copper Chaperone Atox1 Protected the Cochlea From Cisplatin by Regulating the Copper Transport Family and Cell Cycle.
Inhibition of OGFOD1 by FG4592 confers neuroprotection by activating unfolded protein response and autophagy after ischemic stroke.
Mitochondria targeted biomimetic platform for chemo/photodynamic combination therapy against osteosarcoma.
Mechanisms of vemurafenib-induced anti-tumor effects in ATC FRO cells.
Synergistic dual cell therapy for atherosclerosis regression: ROS-responsive Bio-liposomes co-loaded with Geniposide and Emodin.
Protective Effects and Mechanisms of Esculetin against H(2)O(2)-Induced Oxidative Stress, Apoptosis, and Pyroptosis in Human Hepatoma HepG2 Cells.
Enhancing precision medicine: a nomogram for predicting platinum resistance in epithelial ovarian cancer.
Extracellular vesicles secreted from mesenchymal stem cells ameliorate renal ischemia reperfusion injury by delivering miR-100-5p targeting FKBP5/AKT axis.
Melatonin-Derived Carbon Dots with Free Radical Scavenging Property for Effective Periodontitis Treatment via the Nrf2/HO-1 Pathway.
Histone lysine demethylase KDM5B facilitates proliferation and suppresses apoptosis in human acute myeloid leukemia cells through the miR-140-3p/BCL2 axis.
FTO attenuates the cytotoxicity of cisplatin in KGN granulosa cell-like tumour cells by regulating the Hippo/YAP1 signalling pathway.
Jianpi Jiedu decoction reverses 5-fluorouracil resistance in colorectal cancer by suppressing the xCT/GSH/GPX4 axis to induce ferroptosis.
CLPs-miR-103a-2-5p inhibits proliferation and promotes cell apoptosis in AML cells by targeting LILRB3 and Nrf2/HO-1 axis, regulating CD8 + T cell response.
Global gene expression profiling of perirenal brown adipose tissue whitening in goat kids reveals novel genes linked to adipose remodeling.
CircAKT3 alleviates postoperative cognitive dysfunction by stabilizing the feedback cycle of miR-106a-5p/HDAC4/MEF2C axis in hippocampi of aged mice.
Echinacoside alleviates glucocorticoid induce osteonecrosis of femoral head in rats through PI3K/AKT/FOXO1 pathway.
Perfluorooctane sulfonate (PFOS) induces apoptosis and autophagy by inhibition of PI3K/AKT/mTOR pathway in human granulosa cell line KGN.
The circRNA hsa-circ-0013561 regulates head and neck squamous cell carcinoma development via the miR-7-5p/PDK3 axis.
Ssc-miR-429 expression proliles and functions on inducing Leydig cells apoptosis.
FTO demethylates regulates cell-cycle progression by controlling CCND1 expression in luteinizing goat granulosa cells.
VD(3)/VDR attenuates bisphenol A-induced impairment in mouse Leydig cells via regulation of autophagy.
Beneficial effects of human umbilical cord mesenchymal stem cell (HUCMSC) transplantation on cyclophosphamide (CTX)-induced premature ovarian failure (POF) in Tibetan miniature pigs.
Alpha-lipoic Acid Prevents Bone Loss in Type 2 Diabetes and Postmenopausal Osteoporosis Coexisting Conditions by Modulating the YAP/Glut4 Pathway.
Dual-specificity phosphatase 26 protects against kidney injury caused by ischaemia-reperfusion through restraint of TAK1-JNK/p38-mediated apoptosis and inflammation of renal tubular epithelial cells.
Photodynamic therapy inhibits cancer progression and induces ferroptosis and apoptosis by targeting P53/GPX4/SLC7A11 signaling pathways in cholangiocarcinoma.
Effects of Hericium erinaceus polysaccharide in porcine IPEC-J2 intestinal epithelial cells against apoptosis induced by oxidative stress.
Structural characterization and improves cognitive disorder in ageing mice of a glucomannan from Dendrobium huoshanense.
The Effect of Selenium on Endometrial Repair in Goats with Endometritis at High Cortisol Levels.
POSTN knockdown suppresses IL-1β-induced inflammation and apoptosis of nucleus pulposus cells via inhibiting the NF-κB pathway and alleviates intervertebral disc degeneration.
12-O-deacetyl-phomoxanthone A inhibits ovarian tumor growth and metastasis by downregulating PDK4.
Curcuma wenyujin rhizomes extract ameliorates lipid accumulation.
The mechanism of curcumin to protect mouse ovaries from oxidative damage by regulating AMPK/mTOR mediated autophagy.
Glucose regulates the HMGB1 signaling pathway through SIRT1 in glioma.
Experimental verification about treatment of Bu-Shen-Yi-Jing-Fang in Alzheimer's disease by the analysis of the feasible signaling pathway of network pharmacology.
Development and Investigation of an Innovative 3D Biohybrid Based on Collagen and Silk Sericin Enriched with Flavonoids for Potential Wound Healing Applications.
Increasing GSH-Px Activity and Activating Wnt Pathway Promote Fine Wool Growth in FGF5-Edited Sheep.
Oxidative stress-induced EGR1 upregulation promotes NR4A3-mediated nucleus pulposus cells apoptosis in intervertebral disc degeneration.
Potential Molecular Mechanism of Illicium simonsii Maxim Petroleum Ether Fraction in the Treatment of Hepatocellular Carcinoma.
RARRES1 identified by comprehensive bioinformatic analysis and experimental validation as a promising biomarker in Skin Cutaneous Melanoma.
Bradykinin protects nucleus pulposus cells from tert-butyl hydroperoxide-induced damage and delays intervertebral disc degeneration.
S100A6 Regulates nucleus pulposus cell apoptosis via Wnt/β-catenin signaling pathway: an in vitro and in vivo study.
Neurokinin-1 receptor antagonist aprepitant regulates autophagy and apoptosis via ROS/JNK in intrahepatic cholangiocarcinoma.
MicroRNA-322-5p targeting Smurf2 regulates the TGF-β/Smad pathway to protect cardiac function and inhibit myocardial infarction.
A novel p55PIK signaling peptide inhibitor alleviates neuroinflammation via the STAT3/NF-kB signaling pathway in experimental stroke.
Overexpressed FKBP5 mediates colorectal cancer progression and sensitivity to FK506 treatment via the NF-κB signaling pathway.
Ginkgolic acids induce liver injury in mice through cell cycle arrest and immune stress under specific condition.
Anthocyanins from blueberry ameliorated arsenic-induced memory impairment, oxidative stress, and mitochondrial-biosynthesis imbalance in rat hippocampal neurons.
The HSP90AA1 gene is involved in heat stress responses and its functional genetic polymorphisms are associated with heat tolerance in Holstein cows.
Emodin alleviates intestinal ischemia-reperfusion injury through antioxidant stress, anti-inflammatory responses and anti-apoptosis effects via Akt-mediated HO-1 upregulation.
HOXC4 promotes proliferation of pancreatic cancer cells by increasing LDHA-mediated glycolysis.
A black phosphorus nanosheet-based RNA delivery system for prostate cancer therapy by increasing the expression level of tumor suppressor gene PTEN via CeRNA mechanism.
Eurochevalierines A-I, Sesquiterpene Alkaloid Hybrids with Anti-Triple Negative Breast Cancer Activity from Penicillium sp. HZ-5.
Paeoniflorin Promotes Ovarian Development in Mice by Activating Mitophagy and Preventing Oxidative Stress.
The miR-15b-5p/miR-379-3p-FOXO axis regulates cell cycle and apoptosis in scleral remodeling during experimental myopia.
HMGA1 promotes the progression of esophageal squamous cell carcinoma by elevating TKT-mediated upregulation of pentose phosphate pathway.
Intragland Expression of the Shh Gene Alleviates Irradiation-Induced Salivary Gland Injury through Microvessel Protection and the Regulation of Oxidative Stress.
Activation of ARP2/3 and HSP70 Expression by Lipoteichoic Acid: Potential Bidirectional Regulation of Apoptosis in a Mastitis Inflammation Model.
Enhanced therapeutic impact of Shikonin-encapsulated exosomes in the inhibition of colorectal cancer progression.
Paeonia lactiflora Pall. ameliorates acetaminophen-induced oxidative stress and apoptosis via inhibiting the PKC-ERK pathway.
PRAME promotes proliferation of multiple myeloma cells through CTMP/Akt/p21/CCND3 axis by ubiquitinating CTMP and p21.
CHRDL2 activates the PI3K/AKT pathway to ameliorate glucocorticoid-induced damages to bone microvascular endothelial cells (BMECs).
Isorhamnetin inhibits hypertrophic scar formation through TGF-β1/Smad and TGF-β1/CREB3L1 signaling pathways.
Diallyl trisulfide induces pyroptosis and impairs lung CSC-like properties by activating the ROS/Caspase 1 signaling pathway.
Copper exposure induces mitochondrial dysfunction and hepatotoxicity via the induction of oxidative stress and PERK/ATF4 -mediated endoplasmic reticulum stress.
Characterization and safety assessment of bamboo shoot shell cellulose nanofiber: Prepared by acidolysis combined with dynamic high-pressure microfluidization.
Oridonin suppresses the growth of glioblastoma cells via inhibiting Hippo/YAP axis.
Selenomethionine protects the liver from dietary deoxynivalenol exposure via Nrf2/PPARγ-GPX4-ferroptosis pathway in mice.
The lack of homology domain and leucine rich repeat protein phosphatase 2 ameliorates visual impairment in rats with diabetic retinopathy through regulation of the AKT-GSK-3β-Nrf2 signal cascade.
Circular RNA circXPO1 Promotes Multiple Myeloma Progression by Regulating miR-495-3p/DNA Damage-Induced Transcription 4 Axis.
miRNA-211-5p inhibition enhances the protective effect of hucMSC-derived exosome in Aβ(1-40) -induced SH-SY5Y cells by increasing NEP expression.
IGF-I protects porcine granulosa cells from hypoxia-induced apoptosis by promoting homologous recombination repair through the PI3K/AKT/E2F8/RAD51 pathway.
Injectable dexamethasone-loaded peptide hydrogel for therapy of radiation-induced ototoxicity by regulating the mTOR signaling pathway.
pH-driven preparation of pea protein isolate-curcumin nanoparticles effectively enhances antitumor activity.
The P38MAPK/ATF2 signaling pathway is involved in PND in mice.
Extracellular ATP (eATP) inhibits the progression of endometriosis and enhances the immune function of macrophages.
Asperosaponin VI facilitates the regeneration of skeletal muscle injury by suppressing GSK-3β-mediated cell apoptosis.
Zinc finger protein 831 promotes apoptosis and enhances chemosensitivity in breast cancer by acting as a novel transcriptional repressor targeting the STAT3/Bcl2 signaling pathway.
Drp1 regulated PINK1-dependent mitophagy protected duck follicular granulosa cells from acute heat stress injury.
Hsa_circ_0013561 promotes progression of nasopharyngeal carcinoma by activating JAK2/STAT3 signaling pathway.
A novel lncRNA LOC105613571 binding with BDNF in pituitary promotes gonadotropin secretion by AKT/ERK-mTOR pathway in sheep associated with prolificacy.
Polyphyllin II (PPII) Enhances the Sensitivity of Multidrug-resistant A549/DDP Cells to Cisplatin by Modulating Mitochondrial Energy Metabolism.
Icariin protects testicular damage in streptozotocin-induced diabetic rats through regulation of glycolysis pathway.
Corosolic Acid Induced Apoptosis via Upregulation of Bax/Bcl-2 Ratio and Caspase-3 Activation in Cholangiocarcinoma Cells.
Celastrol Alleviates Mitochondrial Oxidative Stress and Brain Injury After Intracerebral Hemorrhage by Promoting OPA1-Dependent Mitochondrial Fusion.
Mechanism study of oleanolic acid derivative, K73-03, inducing cell apoptosis in hepatocellular carcinoma.
Tetrahydroalstonine possesses protective potentials on palmitic acid stimulated SK-N-MC cells by suppression of Aβ1-42 and tau through regulation of PI3K/Akt signaling pathway.
Unlocking the role of EIF5A: A potential diagnostic marker regulating the cell cycle and showing negative correlation with immune infiltration in lung adenocarcinoma.
Protective effect of apelin-13 on ventilator-induced acute lung injury.
Adipose-derived stem cell exosomes promote tumor characterization and immunosuppressive microenvironment in breast cancer.
Fibroblast growth factor 21 alleviates diabetes-induced cognitive decline.
Huaier suppresses cisplatin resistance in non-small cell lung cancer by inhibiting the JNK/JUN/IL-8 signaling pathway.
Jianpi Shengqing Huazhuo Formula improves abnormal glucose and lipid metabolism in obesity by regulating mitochondrial biogenesis.
Uncovering the Therapeutic Potential of Phosphocreatine in Diabetic Retinopathy: Mitigating Mitochondrial Dysfunction and Apoptosis via JAK2/STAT3 Signaling Pathway.
Downregulation of homeobox A1 in human granulosa cells is involved in diminished ovarian reserve through promoting cell apoptosis and mitochondrial dysfunction.
Aluminum-maltol induced oxidative stress and reduced AMPK activity via BCK-related energy supply failure in C6 cell.
Fluorochloridone induces mitochondrial dysfunction and apoptosis in primary goat Sertoli cells.
Therapeutic potential of anti-PIK3CG treatment for multiple myeloma via inhibiting c-Myc pathway.
Bruceine B Displays Potent Antimyeloma Activity by Inducing the Degradation of the Transcription Factor c-Maf.
Targeted Degradation of PCSK9 In Vivo by Autophagy-Tethering Compounds.
E3 ligase TRIM65 alleviates intestinal ischemia/reperfusion injury through inhibition of TOX4-mediated apoptosis.
Chinese herbal medicine alleviates autophagy and apoptosis in ovarian granulosa cells induced by testosterone through PI3K/AKT1/FOXO1 pathway.
Hesperetin promotes bladder cancer cells death via the PI3K/AKT pathway by network pharmacology and molecular docking.
MitomiR-1736-3p regulates copper-induced mitochondrial pathway apoptosis by inhibiting AATF in chicken hepatocytes.
Parkin-mediated mitophagy is a potential treatment for oxaliplatin-induced peripheral neuropathy.
ACE2 activation alleviates sepsis-induced cardiomyopathy by promoting MasR-Sirt1-mediated mitochondrial biogenesis.
GANT61, an inhibitor of Gli1, inhibits the proliferation and migration of hepatocellular carcinoma cells.
Oncogenic lncRNA FAM215A promotes the malignant cell phenotypes of acute myeloid leukemia (AML) cell lines.
Synergistic effect of adavosertib and fimepinostat on acute myeloid leukemia cells by enhancing the induction of DNA damage.
Tetraarsenic tetrasulfide triggers ROS-induced apoptosis and ferroptosis in B-cell acute lymphoblastic leukaemia by targeting HK2.
Serabelisib regulates GSDMD-mediated pyroptosis, apoptosis and migration of hepatoma cells via the PI3K/Akt/E-cadherin signaling pathway.
Iron overload suppresses hippocampal neurogenesis in adult mice: Implication for iron dysregulation-linked neurological diseases.
In situ generation of hybrid alginate hydrogels for enhanced breast tumor ferrotherapy through multiplex magnifying redox imbalances.
Discovery of Novel Marine-Derived Phidiandine/Lipoic Acid Hybrid as a Potential Anti-Atherosclerosis Agent: Design, Synthesis and in Vitro/in Vivo Evaluation.
GK921, a transglutaminase inhibitor, strengthens the antitumor effect of cisplatin on pancreatic cancer cells by inhibiting epithelial-to-mesenchymal transition.
The augmentation of cytotoxic immune cell functionality through physical exertion bolsters the potency of chemotherapy in models of mammary carcinoma.
2α, 3α, 24-Thrihydroxyurs-12-en-24-ursolic acid enhances the cytotoxic effect of cisplatin on oral cancer cells by down-regulating autophagy.
Salvianolic acid A provides neuroprotective effects on cerebral ischemia-reperfusion injury in rats via PKA/CREB/c-Fos signaling pathway.
SPAG6 regulates cell proliferation and apoptosis via TGF-β/Smad signal pathway in adult B-cell acute lymphoblastic leukemia.
Coenzyme Q10 Protects Against Hyperlipidemia-Induced Osteoporosis by Improving Mitochondrial Function via Modulating miR-130b-3p/PGC-1α Pathway.
IGF2BP3 loss inhibits cell progression by upregulating has_circRNA_103820, and hsa_circRNA_103820-encoded peptide inhibits cell progression by inactivating the AKT pathway in lung cancer.
USF2 promotes autophagy and proliferation in chronic lymphocytic leukemia by inhibiting STUB1-induced NFAT5 ubiquitination.
Series of Desloratadine Platinum(IV) Hybrids Displaying Potent Antimetastatic Competence by Inhibiting Epithelial-Mesenchymal Transition and Arousing Immune Response.
Doxycycline hydrochloride inhibits the progress of malignant rhabdoid tumor of kidney by targeting MMP17 and MMP1 through PI3K-Akt signaling pathway.
Cecropin A Alleviates LPS-Induced Oxidative Stress and Apoptosis of Bovine Endometrial Epithelial Cells.
Genome-wide CRISPR screen identifies ESPL1 limits the response of gastric cancer cells to apatinib.
Protective effects of Pt-N-C single-atom nanozymes against myocardial ischemia-reperfusion injury.
Exosomes of endothelial progenitor cells repair injured vascular endothelial cells through the Bcl2/Bax/Caspase-3 pathway.
Modification of BCLX pre-mRNA splicing has antitumor efficacy alone or in combination with radiotherapy in human glioblastoma cells.
miR-34c-5p inhibited fibroblast proliferation, differentiation and epithelial-mesenchymal transition in benign airway stenosis via MDMX/p53 pathway.
Xingnaojing injection alleviates cerebral ischemia/reperfusion injury through regulating endoplasmic reticulum stress in Vivo and in Vitro.
Oridonin-induced ferroptosis and apoptosis: a dual approach to suppress the growth of osteosarcoma cells.
High expression of TBRG4 in relation to unfavorable outcome and cell ferroptosis in hepatocellular carcinoma.
Baicalein improves Na(2)SeO(3) induced cataract by enhancing the antioxidant capacity of juvenile Sprague Dawley Rat.
β-Lapachone induces ferroptosis of colorectal cancer cells via NCOA4-mediated ferritinophagy by activating JNK pathway.
Quercetin attenuates cadmium-induced hepatotoxicity by suppressing oxidative stress and apoptosis in rat.
Amitraz mechanisms of cytotoxicity in a characterized SH-SY5Y cells spheroid model.
Melatonin antagonizes oxidative stress-induced apoptosis in retinal ganglion cells through activating the thioredoxin-1 pathway.
Geniposide alleviates heart failure with preserved ejection fraction in mice by regulating cardiac oxidative stress via MMP2/SIRT1/GSK3β pathway.
Novel isobavachalcone derivatives induce apoptosis and necroptosis in human non-small cell lung cancer H1975 cells.
Revealing the mechanism of Gualou-Xiebai against myocardial ischemia based on network pharmacology and energy metabolism strategies.
A cisplatin and disulphiram co-loaded inclusion complex overcomes drug resistance by inhibiting cancer cell stemness in non-small cell lung cancer.
Mitochondrial HKDC1 suppresses oxidative stress and apoptosis by regulating mitochondrial function in goose fatty liver.
Self-assembled metal-polyphenolic based multifunctional nanomedicine to improve therapy treatment of pancreatic cancer by inhibition of glutamine metabolism.
Critical role of apoptosis in MeCP2-mediated epithelial-mesenchymal transition of ARPE-19 cells.
PX-478 induces apoptosis in acute myeloid leukemia under hypoxia by inhibiting the PI3K/AKT/mTOR pathway through downregulation of GBE1.
ITFG2 as a NEDD4-2 inhibitor: Preserving calcium homeostasis to prevent myocardial ischemic injury.
Sulforaphane acts through the NFE2L2/AMPK signaling pathway to protect boar spermatozoa from cryoinjury by activating antioxidant defenses.
Oleanolic acid promotes porcine oocyte maturation by activating the Nrf2/HO-1 signalling pathway.
JuA alleviates liver ischemia-reperfusion injury by activating AKT/NRF2/HO-1 pathways.
In vitro and in vivo studies of a decanuclear Ni(II) complex as a potential anti-breast cancer agent.
Avenanthramide A potentiates Bim-mediated antineoplastic properties of 5-fluorouracil via targeting KDM4C/MIR17HG/GSK-3β negative feedback loop in colorectal cancer.
A combined treatment with Ursolic acid and Solasodine inhibits colorectal cancer progression through the AKT1/ERK1/2-GSK-3β-β-catenin axis.
Ginkgolide A enhances FoxO1 expression and reduces endoplasmic reticulum stress to mitigate osteoarthritis in mice.
Identification of a nomogram predicting overall survival based on ADAP2-related apoptosis genes in gliomas.
Mechanism investigation of Forsythoside A against esophageal squamous cell carcinoma in vitro and in vivo.
MiR-490-3p promotes cell apoptosis and cell-cycle arrest in osteosarcoma via the modulation of CDCA8/ATF3 by targeting NUSAP1.
miR-134-3p Regulates Cell Proliferation and Apoptosis by Targeting INHBA via Inhibiting the TGF-β/PI3K/AKT Pathway in Sheep Granulosa Cells.
OTULIN confers cisplatin resistance in osteosarcoma by mediating GPX4 protein homeostasis to evade the mitochondrial apoptotic pathway.
IGFALS suppresses hepatocellular carcinoma progression by stabilizing PPAR-γ.
MUL1 identified as mitochondria-linked biomarker promoting cisplatin resistance in OC cells.
SLC25A21 correlates with the prognosis of adult acute myeloid leukemia through inhibiting the growth of leukemia cells via downregulating CXCL8.
LOC730101 improves ovarian cancer drug sensitivity by inhibiting autophagy-mediated DNA damage repair via BECN1.
Elaiophylin targets EIF4B to suppress the growth of esophageal squamous cell carcinoma via the PI3K/AKT signaling pathway.
Transcription factor PRRX1-activated ANXA6 facilitates EGFR-PKCα complex formation and enhances cisplatin sensitivity in bladder cancer.
Matrine promotes colorectal cancer apoptosis by downregulating shank-associated RH domain interactor expression.
Discovery of the First BRD4 Second Bromodomain (BD2)-Selective Inhibitors.
Enhancing therapeutic efficacy in homologous recombination-proficient pancreatic cancer via the combination of PARP1-PROTAC and a BRD4 inhibitor.
H(2)S-releasing oridonin derivatives with improved antitumor activity by inhibiting the PI3K/AKT pathway.
Isoliquiritigenin Alleviates Diabetic Kidney Disease via Oxidative Stress and the TLR4/NF-κB/NLRP3 Inflammasome Pathway.
Presenilin2 D439A Mutation Induces Dysfunction of Mitochondrial Fusion/Fission Dynamics and Abnormal Regulation of GTPase Activity.
SNX14 inhibits autophagy via the PI3K/AKT/mTOR signaling cascade in breast cancer cells.
Long noncoding RNA ANRIL alleviates hypoxia-induced pulmonary microvascular endothelial cell damage.
Digitoxin inhibits ICC cell properties via the NF‑κB/ST6GAL1 signaling pathway.
Hematoporphyrin derivative-mediated photodynamic techniques for the diagnosis and treatment of chordoma.
Integration of serum pharmacochemistry with network pharmacology to reveal the potential mechanism of Yangqing Chenfei formula for the treatment of silicosis.
Fungal metabolite altersolanol a exhibits potent cytotoxicity against human placental trophoblasts in vitro via mitochondria-mediated apoptosis.
SND1 Promotes Radioresistance in Cervical Cancer Cells by Targeting the DNA Damage Response.
MGST3 regulates BACE1 protein translation and amyloidogenesis by controlling the RGS4-mediated AKT signaling pathway.
Identifying SLC2A6 as the novel protective factor in breast cancer by TP53-related genes affecting M1 macrophage infiltration.
Improving Granulosa Cell Function in Premature Ovarian Failure with Umbilical Cord Mesenchymal Stromal Cell Exosome-Derived hsa_circ_0002021.
Tumor-targeted nano-assemblies for energy-blocking cocktail therapy in cancer.
Ginkgolide B effectively mitigates neuropathic pain by suppressing the activation of the NLRP3 inflammasome through the induction of mitophagy in rats.
Lipoamide Attenuates Hypertensive Myocardial Hypertrophy Through PI3K/Akt-Mediated Nrf2 Signaling Pathway.
Mzb1 Attenuates Atherosclerotic Plaque Vulnerability in ApoE-/- Mice by Alleviating Apoptosis and Modulating Mitochondrial Function.
N-acetylcysteine stimulates the proliferation and differentiation in heat-stressed skeletal muscle cells.
Canadine Platinum(IV) Complexes Targeting Epithelial-Mesenchymal Transition as Antiproliferative and Antimetastatic Agents.
LINC01410 accelerates the invasion of trophoblast cells by modulating METTL3/Fas.
Melatonin alleviates palmitic acid-induced mitochondrial dysfunction by reducing oxidative stress and enhancing autophagy in bovine endometrial epithelial cells.
Glycyrrhetinic acid triggers a protective autophagy by inhibiting the JAK2/STAT3 pathway in cerebral ischemia/reperfusion injury.
Bacillus subtilis alleviates excessive apoptosis of intestinal epithelial cells in intrauterine growth restriction suckling piglets via the members of Bcl-2 and caspase families.
Synergistic effects of plasma-activated medium in combination with Baicalin against neuronal damage.
BCAA mediated microbiota-liver-heart crosstalk regulates diabetic cardiomyopathy via FGF21.
Bombinin-BO1 induces hepatocellular carcinoma cell-cycle arrest and apoptosis via the HSP90A-Cdc37-CDK1 axis.
Effect of acacetin on inhibition of apoptosis in Helicobacter pylori-infected gastric epithelial cell line.
Fisetin Promotes Functional Recovery after Spinal Cord Injury by Inhibiting Microglia/Macrophage M1 Polarization and JAK2/STAT3 Signaling Pathway.
Does rAj-Tspin, a novel peptide from A. japonicus, exert antihepatocellular carcinoma effects via the ITGB1/ZYX/FAK/AKT signaling pathway?
FGF2 promotes the proliferation of injured granulosa cells in premature ovarian failure via Hippo-YAP signaling pathway.
Sodium octanoate alleviates cardiac and cerebral injury after traumatic cardiac arrest in a porcine model.
Botulinum Toxin Type A Alleviates Androgenetic Alopecia by Inhibiting Apoptosis of Dermal Papilla Cells via Targeting circ_0135062/miR-506-3p/Bax Axis.
LncRNA LOXL1-AS1 promotes proliferation and invasion and inhibits apoptosis in retinoblastoma by regulating the MAPK signaling pathway.
IRF4 induces M1 macrophage polarization and aggravates ulcerative colitis progression by the Bcl6-dependent STAT3 pathway.
Long-term Cu exposure alters CYP450s activity and induces jejunum injury and apoptosis in broilers.
Integrating Network Pharmacology and Experimental Validation to Reveal the Mechanism of Vine Grape Tea Polyphenols on Hyperuricemia-Induced Renal Injury in Mice.
TuBG1 promotes hepatocellular carcinoma via ATR/P53-apoptosis and cycling pathways.
A pyrazolopyridine as a novel AhR signaling activator with anti-breast cancer properties in vitro and in vivo.
Tris-Functionalized Polyoxotungstovanadate-Mediated Antitumor Efficacy Involves Multiple Cell Death Pathways.
Ginsenoside Rk1 induces autophagy-dependent apoptosis in hepatocellular carcinoma by AMPK/mTOR signaling pathway.
Rosmarinic acid mitigates acrylamide induced neurotoxicity via suppressing endoplasmic reticulum stress and inflammation in mouse hippocampus.
Regulatory mechanism of perinatal nonylphenol exposure on cardiac mitochondrial autophagy and the PINK1/Parkin signaling pathway in male offspring rats.
Diallyl disulfide synergizes with melphalan to increase apoptosis and DNA damage through elevation of reactive oxygen species in multiple myeloma cells.
Oxaliplatin-Loaded Mil-100(Fe) for Chemotherapy-Ferroptosis Combined Therapy for Gastric Cancer.
PPARγ alleviates preeclampsia development by regulating lipid metabolism and ferroptosis.
Anticancer properties and metabolomic profiling of Shorea roxburghii extracts toward gastrointestinal cancer cell lines.
Baicalin reduces inflammation to inhibit lung cancer via targeting SOCS1/NF-κB/STAT3 axis.
The mitochondria-targeted Kaempferol nanoparticle ameliorates severe acute pancreatitis.
HIST3H2A promotes the progression of prostate cancer through inhibiting cell necroptosis.
Targeting IDH1-Mutated Oligodendroglioma with Acid Ceramidase Inhibitors.
Network pharmacology and experimental validation of effects of total saponins extracted from Abrus cantoniensis Hance on acetaminophen-induced liver injury.
Tumor Supplying Artery Injection of Liposome@Sunitinib Could Effectively Inhibit the Progression of Kidney Tumor.
Granulysin-mediated reduction of PDZRN3 induces Cx43 gap junctions activity exacerbating skin damage in trichloroethylene hypersensitivity syndrome.
Construction and validation of a hypoxia-related gene signature to predict the prognosis of breast cancer.
CircGPC3 promotes hepatocellular carcinoma progression and metastasis by sponging miR-578 and regulating RAB7A/PSME3 expression.
Erianin Exerts Antineoplastic Effects on Esophageal Squamous Cell Carcinoma Cells by Activating the cGMP-PKG Signaling Pathway.
Sulforaphane Suppresses MCF-7 Breast Cancer Cells Growth via miR-19/PTEN Axis to Antagonize the Effect of Butyl Benzyl Phthalate.
Diallyl Trisulfide Suppresses the Renal Cancer Stem-like Cell Properties via Nanog.
Semisynthesis and in Vitro Anti-cancer Effect of New Magnolol Derivatives on the Cell Proliferation, Apoptosis, Migration, and Invasion of Human Hepatocellular Carcinoma SMMC-7721 Cells.
Overexpressing six-transmembrane protein of prostate 2 (STAMP2) alleviates sepsis-induced acute lung injury probably by hindering M1 macrophage polarization via the NF-κB pathway.
Phenolic profile, antioxidation and anti-proliferation activity of phenolic-rich extracts from Sanghuangporusvaninii.
Baicalin Reduces Immune Cell Infiltration by Inhibiting Inflammation and Protecting Tight Junctions in Ischemic Stroke Injury.
The SARS-CoV-2 spike glycoprotein interacts with MAO-B and impairs mitochondrial energetics.
Andrographolide alleviates paraquat-induced acute lung injury by activating the Nrf2/HO-1 pathway.
Penehyclidine Hydrochloride Protects Rat Cardiomyocytes from Ischemia- Reperfusion Injury by Platelet-derived Growth Factor-B.
Lycium barbarum Polysaccharides Regulating miR-181/Bcl-2 Decreased Autophagy of Retinal Pigment Epithelium with Oxidative Stress.
Liraglutide Attenuates Hepatic Oxidative Stress, Inflammation, and Apoptosis in Streptozotocin-Induced Diabetic Mice by Modulating the Wnt/β-Catenin Signaling Pathway.
Study on Neuroprotective Mechanism of Houshiheisan in Ischemic Stroke Based on Transcriptomics and Experimental Verification.
A Water-Soluble Hydrogen Sulfide Donor Suppresses the Growth of Hepatocellular Carcinoma via Inhibiting the AKT/GSK-3β/β-Catenin and TGF-β/Smad2/3 Signaling Pathways.
RING Finger Protein 10 Regulates AP-1/Meox2 to Mediate Pirarubicin-Induced Cardiomyocyte Apoptosis.
P7C3-A20 Attenuates Microglial Inflammation and Brain Injury after ICH through Activating the NAD(+)/Sirt3 Pathway.
Circular RNA_HIPK3-Targeting miR-93-5p Regulates KLF9 Expression Level to Control Acute Kidney Injury.
Antioxioxidant and antiapoptotic effects of Thymosin β4 in Aβ-induced SH-SY5Y cells via the 5-HTR1A/ERK axis.
Thalidomide Alleviates Apoptosis, Oxidative Damage and Inflammation Induced by Pemphigus Vulgaris IgG in HaCat Cells and Neonatal Mice Through MyD88.
An Integrative Pharmacology-Based Strategy to Uncover the Mechanism of Zuogui Jiangtang Shuxin Formula in Diabetic Cardiomyopathy.
Mifepristone inhibits hepatoma growth by enhancing the GR-HSP60-survivin interaction to facilitate survivin degradation.
Zhoushi Qiling decoction inhibits proliferation of human prostate cancer cells through IL6/STAT3 pathway.
Myricetin suppresses TGF-β-induced epithelial-to-mesenchymal transition in ovarian cancer.
Blockage of S100A8/A9 ameliorates septic nephropathy in mice.
Pterostilbene attenuates microglial inflammation and brain injury after intracerebral hemorrhage in an OPA1-dependent manner.
Reactivation of mutant p53 in esophageal squamous cell carcinoma by isothiocyanate inhibits tumor growth.
Adjuvant therapy with Huatan Sanjie Granules improves the prognosis of patients with primary liver cancer: a cohort study and the investigation of its mechanism of action based on network pharmacology.
HSP105 suppresses the progression of cutaneous squamous cell carcinoma by activating the P53 signaling pathway.
Histone H3K27 methyltransferase EZH2 regulates apoptotic and inflammatory responses in sepsis-induced AKI.
Ly6D facilitates chemoresistance in laryngeal squamous cell carcinoma through miR-509/β-catenin signaling pathway.
ZY-444 inhibits the growth and metastasis of prostate cancer by targeting TNFAIP3 through TNF signaling pathway.
Fucose ameliorates the proinflammatory property of Fusobacterium nucleatum in colitis via altering its metabolism.
RNA N6-methyladenosine reader IGF2BP3 promotes acute myeloid leukemia progression by controlling stabilization of EPOR mRNA.
Combined effects of EMP and RF field on emotional behavior in mice.
Shiga toxin 2 A-subunit induces mitochondrial damage, mitophagy and apoptosis via the interaction of Tom20 in Caco-2 cells.
Itraconazole inhibits proliferation, induces apoptosis, and reduces angiogenesis of hemangioma endothelial cells by downregulating the hedgehog signaling pathway.
Over-expression of miR-3584-5p Represses Nav1.8 Channel Aggravating Neuropathic Pain caused by Chronic Constriction Injury.
Biomarkers based on multiplatform comprehensive analysis: A systematic analysis of Geng-Nian-Shu in perimenopausal syndrome.
Long noncoding RNA LINC00173 induces radioresistance in nasopharyngeal carcinoma via inhibiting CHK2/P53 pathway.
MicroRNA-139-5p suppresses non-small cell lung cancer progression by targeting ATAD2.
Alleviative Effect of Threonine on Cadmium-Induced Liver Injury in Mice.
Degradation of histone deacetylase 6 alleviates ROS-mediated apoptosis in renal ischemia-reperfusion injury.
Artesunate alleviates intestinal ischemia/reperfusion induced acute lung injury via up-regulating AKT and HO-1 signal pathway in mice.
Calycosin inhibits triple-negative breast cancer progression through down-regulation of the novel estrogen receptor-α splice variant ER-α30-mediated PI3K/AKT signaling pathway.
Extracellular vesicles produced by avian pathogenic Escherichia coli (APEC) activate macrophage proinflammatory response and neutrophil extracellular trap (NET) formation through TLR4 signaling.
Generation of a humanized mesonephros in pigs from induced pluripotent stem cells via embryo complementation.
CBX3 promotes clear cell renal carcinoma through PI3K/AKT activation and aberrant immunity.
β-Sitosterol Suppresses Lipopolysaccharide-Induced Inflammation and Lipogenesis Disorder in Bovine Mammary Epithelial Cells.
Intercellular adhesion molecule 2 as a novel prospective tumor suppressor induced by ERG promotes ubiquitination-mediated radixin degradation to inhibit gastric cancer tumorigenicity and metastasis.
Depletion of G9A attenuates imiquimod-induced psoriatic dermatitis via targeting EDAR-NF-κB signaling in keratinocyte.
[A Novel Chinese Medicine Formula Inhibits Non-small Cell Lung Cancer by Triggering Oxidative Stress Dependent on Pentose Phosphate Pathway].
FGF2 Rescued Cisplatin-Injured Granulosa Cells through the NRF2-Autophagy Pathway.
Umbilical cord mesenchymal stem cells relieve osteoarthritis in rats through immunoregulation and inhibition of chondrocyte apoptosis.
Obatoclax Rescues FUS-ALS Phenotypes in iPSC-Derived Neurons by Inducing Autophagy.
Long non-coding RNA PFI inhibits apoptosis of alveolar epithelial cells to alleviate lung injury via miR-328-3p/Creb1 axis.
Gambogenic acid induces cell death in human osteosarcoma through altering iron metabolism, disturbing the redox balance, and activating the P53 signaling pathway.
LncRNA AOC4P impacts the differentiation of macrophages and T-lymphocyte by regulating the NF-κB pathways of KGN cells: Potential pathogenesis of polycystic ovary syndrome.
Effect of eIF2α in Neuronal Injury Induced by High Glucose and the Protective Mechanism of Resveratrol.
Bavachinin Ameliorates Rheumatoid Arthritis Inflammation via PPARG/PI3K/AKT Signaling Pathway.
Comprehensive analysis of clinical prognostic features and tumor microenvironment landscape of CD11b(+)CD64(+) patients with acute myeloid leukemia.
Electroacupuncture inhibits hippocampal neuronal apoptosis and improves cognitive dysfunction in mice with vascular dementia via the JNK signaling pathway.
HBV precore G1896A mutation promotes growth of hepatocellular carcinoma cells by activating ERK/MAPK pathway.
BCKDHA contributes to melanoma progression by promoting the expressions of lipogenic enzymes FASN and ACLY.
The effect of small molecule inhibitor NSC348884 on nucleophosmin 1-mutated acute myeloid leukemia cells.
Depleting ANTXR1 suppresses glioma growth via deactivating PI3K/AKT pathway.
Acquired resistance to venetoclax plus azacitidine in acute myeloid leukemia: In vitro models and mechanisms.
Targeting DHODH reveals therapeutic opportunities in ATRA-resistant acute promyelocytic leukemia.
Anti-rheumatoid arthritis effects of total saponins from Rhizoma Panacis Majoris on adjuvant-induced arthritis in rats and rheumatoid arthritis fibroblast-like synoviocytes.
Ganoderma lucidum polysaccharide peptide (GLPP) attenuates rheumatic arthritis in rats through inactivating NF-κB and MAPK signaling pathways.
MiR-132-3p activation aggravates renal ischemia-reperfusion injury by targeting Sirt1/PGC1alpha axis.
CT2-3 induces cell cycle arrest and apoptosis in rheumatoid arthritis fibroblast-like synoviocytes through regulating PI3K/AKT pathway.
Zigui-Yichong-Fang protects against cyclophosphamide-induced premature ovarian insufficiency via the SIRT1/Foxo3a pathway.
A modified Fangji Huangqi decoction ameliorates pulmonary artery hypertension via phosphatidylinositide 3-kinases/protein kinase B-mediated regulation of proliferation and apoptosis of smooth muscle cells in vitro and in vivo.
Decreased HAT1 expression in granulosa cells disturbs oocyte meiosis during mouse ovarian aging.
Coumarins from Jinhua Finger Citron: Separation by Liquid-Liquid Chromatography and Potential Antitumor Activity.
N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity.
Acteoside protects podocyte against apoptosis through regulating AKT/GSK-3β signaling pathway in db/db mice.
ALKBH5-mediated m(6)A demethylation of HS3ST3B1-IT1 prevents osteoarthritis progression.
The Wnt/β-catenin signaling pathway inhibits osteoporosis by regulating the expression of TERT: an in vivo and in vitro study.
Dendrobium officinale polysaccharide Converts M2 into M1 Subtype Macrophage Polarization via the STAT6/PPAR-r and JAGGED1/NOTCH1 Signaling Pathways to Inhibit Gastric Cancer.
Matrix stiffness induces Drp1-mediated mitochondrial fission through Piezo1 mechanotransduction in human intervertebral disc degeneration.
Metformin combined with glucose starvation synergistically suppress triple-negative breast cancer by enhanced unfolded protein response.
Oral administration of sophoricoside (SOP) inhibits neuronal damage and neuroinflammation to curb neurodegeneration in Parkinson's disease.
Dapagliflozin suppress endoplasmic reticulum stress mediated apoptosis of chondrocytes by activating Sirt1.
Chronic exposure to low-dose deltamethrin can lead to colon tissue injury through PRDX1 inactivation-induced mitochondrial oxidative stress injury and gut microbial dysbiosis.
FUT8-Mediated Core Fucosylation Promotes the Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension.
The Extract of Pinellia Ternata-Induced Apoptosis of Leukemia Cells by Regulating the Expression of Bax, Bcl-2 and Caspase-3 Protein Expression in Mice.
Knockdown of LIMD2 inhibits the progression of ovarian carcinoma through ERK1/2 pathway.
Fusaric acid inhibits proliferation and induces apoptosis through triggering endoplasmic reticulum stress in MCF-7 human breast cancer cells.
Correlation of 3'-phosphoadenosine-5'-phosphosulfate synthase 1 (PAPSS1) expression with clinical parameters and prognosis in esophageal squamous cell carcinoma.
A Responsive Nanorobot Modulates Intracellular Zinc Homeostasis to Amplify Mitochondria-Targeted Phototherapy.
Design and synthesis of 3,4-seco-lupane triterpene derivatives to resist myocardial ischemia-reperfusion injury by inhibiting oxidative stress-mediated mitochondrial dysfunction via the PI3K/AKT/HIF-1α axis.
The role of the Gas6/TAM signal pathway in the LPS-induced pulmonary epithelial cells injury.
Linderalactone mitigates diabetic cardiomyopathy in mice via suppressing the MAPK/ATF6 pathway.
Arecoline hydrobromide suppresses PI3K/AKT pathway in rheumatoid arthritis synovial fibroblasts and relieves collagen-induced arthritis in mice.
3D Elastomeric Stent Functionalized with Antioxidative and Perivascular Tissue Regenerative Activities Ameliorated PVT Deprivation-Induced Vein Graft Failure.
ADORA2A promotes proliferation and inhibits apoptosis through PI3K/AKT pathway activation in colorectal carcinoma.
Ferulic acid ameliorates the quality of in vitro-aged bovine oocytes by suppressing oxidative stress and apoptosis.
TROP2-directed nanobody-drug conjugate elicited potent antitumor effect in pancreatic cancer.
Duck Tembusu virus NS3 protein induces apoptosis by activating the PERK/PKR pathway and mitochondrial pathway.
Hypoxic preconditioned MSCs-derived small extracellular vesicles for photoreceptor protection in retinal degeneration.
A prognostic risk model for programmed cell death and revealing TRIB3 as a promising apoptosis suppressor in renal cell carcinoma.
Erythropoietin suppresses osteoblast apoptosis and ameliorates steroid-induced necrosis of the femoral head in rats by inhibition of STAT1-caspase 3 signaling pathway.
Toxic effects of bisphenol S on mice heart and human umbilical cord endothelial cells.
Biomimetic Construction of Degradable DNAzyme-Loaded Nanocapsules for Self-Sufficient Gene Therapy of Pulmonary Metastatic Breast Cancer.
Polytetrafluorethylene microplastic particles mediated oxidative stress, inflammation, and intracellular signaling pathway alteration in human derived cell lines.
Morusinol Extracted from Morus alba Inhibits Cell Proliferation and Induces Autophagy via FOXO3a Nuclear Accumulation-Mediated Cholesterol Biosynthesis Obstruction in Colorectal Cancer.
Inhibition of endogenous hydrogen sulfide production suppresses the growth of nasopharyngeal carcinoma cells.
TREM2 Inhibits Tau Hyperphosphorylation and Neuronal Apoptosis via the PI3K/Akt/GSK-3β Signaling Pathway In vivo and In vitro.
Alpha lipoamide inhibits diabetic kidney fibrosis via improving mitochondrial function and regulating RXRα expression and activation.
The pan-cancer analysis of the oncogenic role of FAM72A as a BRCA prognostic biomarker and immunotherapeutic target.
Experimental study of the effects of absorbable gelatin sponge and non‑absorbable polyvinyl alcohol particle material used in transcatheter arterial embolization on liver tissues.
Inhibitory effect and mechanism of hirsuteine on NCI‑H1299 lung cancer cell lines.
Lyn attenuates sepsis-associated acute kidney injury by inhibition of phospho-STAT3 and apoptosis.
Anionic liposomes prepared without organic solvents for effective siRNA delivery.
CBL0137 activates ROS/BAX signaling to promote caspase-3/GSDME-dependent pyroptosis in ovarian cancer cells.
High uric acid aggravates apoptosis of lung epithelial cells induced by cigarette smoke extract through downregulating PRDX2 in chronic obstructive pulmonary disease.
DNMT3A R882H mutation promotes acute leukemic cell survival by regulating glycolysis through the NRF2/NQO1 axis.
Cryptotanshinone induces apoptosis of activated hepatic stellate cells via modulating endoplasmic reticulum stress.
Red Ginseng Improves D-galactose-Induced Premature Ovarian Failure in Mice Based on Network Pharmacology.
Inhibition of AGEs-RAGE-PP2A Axis Alleviates Cognitive Impairment after Chronic Heart Failure.
The soluble guanylyl cyclase pathway is inhibited to evade androgen deprivation-induced senescence and enable progression to castration resistance.
Resveratrol Enhances Temozolomide Efficacy in Glioblastoma Cells through Downregulated MGMT and Negative Regulators-Related STAT3 Inactivation.
Chrysomycin A Regulates Proliferation and Apoptosis of Neuroglioma Cells via the Akt/GSK-3β Signaling Pathway In Vivo and In Vitro.
The Nrf2/HMGB1/NF-κB axis modulates chondrocyte apoptosis and extracellular matrix degradation in osteoarthritis.
Aristolocholic acid I promotes renal tubular epithelial fibrosis by upregulating matrix metalloproteinase-9 expression via activating the C3a/C3aR axis of macrophages.
Protective mechanism of gold nanoparticles on human neural stem cells injured by β-amyloid protein through miR-21-5p/SOCS6 pathway.
Electroacupuncture alleviates early brain injury via modulating microglia polarization and suppressing neuroinflammation in a rat model of subarachnoid hemorrhage.
Loss of pleckstrin homology domain and leucine-rich repeat protein phosphatase 2 has protective effects on high glucose-injured retinal ganglion cells via the effect on the Akt-GSK-3β-Nrf2 pathway.
Myricetin improves apoptosis after ischemic stroke via inhibiting MAPK-ERK pathway.
Ginsenoside compound K reduces ischemia/reperfusion-induced neuronal apoptosis by inhibiting PTP1B-mediated IRS1 tyrosine dephosphorylation.
The PERK/ATF4/CHOP signaling branch of the unfolded protein response mediates cisplatin-induced ototoxicity in hair cells.
CircTNPO3 promotes hepatocellular carcinoma progression by sponging miR-199b-5p and regulating STRN expression.
Pharmacological network analysis of the functions and mechanism of kaempferol from Du Zhong in intervertebral disc degeneration (IDD).
Linear ubiquitination of LKB1 activates AMPK pathway to inhibit NLRP3 inflammasome response and reduce chondrocyte pyroptosis in osteoarthritis.
OASL knockdown inhibits the progression of stomach adenocarcinoma by regulating the mTORC1 signaling pathway.
Up-regulation of STRA6 predicts poor prognosis and contributes to oxaliplatin resistance in colorectal cancer.
Decreased AGGF1 facilitates the progression of placenta accreta spectrum via mediating the P53 signaling pathway under the regulation of miR-1296-5p.
Cyclin-dependent kinase subunit2 (CKS2) promotes malignant phenotypes and epithelial-mesenchymal transition-like process in glioma by activating TGFβ/SMAD signaling.
Plumbagin induces the apoptosis of drug-resistant oral cancer in vitro and in vivo through ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction.
Ursolic Acid Suppresses Colorectal Cancer by Down-Regulation of Wnt/β-Catenin Signaling Pathway Activity.
Autophagy-Targeted Calcium Phosphate Nanoparticles Enable Transarterial Chemoembolization for Enhanced Cancer Therapy.
The Wnt/β-catenin pathway regulates inflammation and apoptosis in ventilator-induced lung injury.
PTMA binds to HMGB1 to regulate mitochondrial oxidative phosphorylation and thus affect the malignant progression of esophageal squamous cell carcinoma.
The effects of the prognostic biomarker SAAL1 on cancer growth and its association with the immune microenvironment in lung adenocarcinoma.
ZNF582 overexpression restrains the progression of clear cell renal cell carcinoma by enhancing the binding of TJP2 and ERK2 and inhibiting ERK2 phosphorylation.
Astaxanthin Alleviates Aflatoxin B1-Induced Oxidative Stress and Apoptosis in IPEC-J2 Cells via the Nrf2 Signaling Pathway.
Human umbilical cord mesenchymal stem cells conditioned medium exerts anti-tumor effects on KGN cells in a cell density-dependent manner through activation of the Hippo pathway.
AAZ2 induces mitochondrial-dependent apoptosis by targeting PDK1 in gastric cancer.
Low-density small extracellular vesicles in bovine follicular fluid carrying let-7i target FASLG to inhibit granulosa cells apoptosis.
Fam72a functions as a cell-cycle-controlled gene during proliferation and antagonizes apoptosis through reprogramming PP2A substrates.
Mir-153-3p Modulates the Breast Cancer Cells' Chemosensitivity to Doxorubicin by Targeting KIF20A.
Exploring the potential of ginseng glycoprotein to improve learning and memory in mice via Notch signaling pathway and structural analysis using multi-information fusion based on liquid chromatography-mass spectrometry.
Aidi injection enhances the anti-tumor impact of doxorubicin in H22 tumor-containing mice.
Zearalenone induces oxidative stress and autophagy in goat Sertoli cells.
IFT20 Confers Paclitaxel Resistance by Triggering β-arrestin-1 to Modulate ASK1 Signaling in Breast Cancer.
Git1-PGK1 interaction achieves self-protection against spinal cord ischemia-reperfusion injury by modulating Keap1/Nrf2 signaling.
taVNS Alleviates Sevoflurane-Induced Cognitive Dysfunction in Aged Rats Via Activating Basal Forebrain Cholinergic Neurons.
1,25-Dihydroxvitamin D3 attenuates the damage of human immortalised keratinocytes caused by Ultraviolet-B.
Silencing of FAM111B inhibits tumor growth and promotes apoptosis by decreasing AKT activity in ovarian cancer.
Sulconazole Induces PANoptosis by Triggering Oxidative Stress and Inhibiting Glycolysis to Increase Radiosensitivity in Esophageal Cancer.
HCH6-1, an antagonist of formyl peptide receptor-1, exerts anti-neuroinflammatory and neuroprotective effects in cellular and animal models of Parkinson's disease.
Toosendanin-induced apoptosis of CMT-U27 is mediated through the mitochondrial apoptotic pathway.
Excessive ER-phagy contributes to ochratoxin A-induced apoptosis.
HDAC inhibitor HPTA initiates anti-tumor response by CXCL9/10-recruited CXCR3(+)CD4(+)T cells against PAHs carcinogenicity.
miR-30c-2-3p suppresses the proliferation of human renal cell carcinoma cells by targeting TOP2A.
Aloe-emodin ameliorated MI-induced cardiac remodeling in mice via inhibiting TGF-β/SMAD signaling via up-regulating SMAD7.
Potential Mechanisms of Metformin-Induced Apoptosis in HeLa Cells.
C11orf54 promotes DNA repair via blocking CMA-mediated degradation of HIF1A.
Codelivery of TRAIL and Mitomycin C via Liposomes Shows Improved Antitumor Effect on TRAIL-Resistant Tumors.
Risk signature identification and NPRL2 affects sunitinib sensitivity in clear cell renal cell carcinoma.
METTL3-mediated m(6)A modification of IGFBP7-OT promotes osteoarthritis progression by regulating the DNMT1/DNMT3a-IGFBP7 axis.
EZH2 Gene Knockdown Inhibits Sheep Pituitary Cell Proliferation via Downregulating the AKT/ERK Signaling Pathway.
Synergism Antiproliferative Effects of Apigenin and Naringenin in NSCLC Cells.
Effect of Lactobacillus delbrueckii subsp. lactis on vaginal radiotherapy for gynecological cancer.
A multi-bioresponsive self-assembled nano drug delivery system based on hyaluronic acid and geraniol against liver cancer.
Acupuncture regulates the apoptosis of ovarian granulosa cells in polycystic ovarian syndrome-related abnormal follicular development through LncMEG3-mediated inhibition of miR-21-3p.
Granulosa cells undergo BPA-induced apoptosis in a miR-21-independent manner.
DR1-CSE/H(2)S pathway upregulates autophagy and inhibits H9C2 cells damage induced by high glucose.
Natural Oncolysis of Enterovirus 71 in Antitumor Therapy of Colorectal Cancer.
USP51/PD-L1/ITGB1-deployed juxtacrine interaction plays a cell-intrinsic role in promoting chemoresistant phenotypes in non-small cell lung cancer.
Circular forms of dedicator of cytokinesis 1 promotes breast cancer progression by derepressing never in mitosis related kinase 2 via sponging miR-128-3p.
Destruction of the cellular antioxidant pool contributes to resveratrol-induced senescence and apoptosis in lung cancer.
A mitochondria-targeting ROS-activated nanoprodrug for self-augmented antitumor oxidation therapy.
A role for fibroblast-derived SASP factors in the activation of pyroptotic cell death in mammary epithelial cells.
Palmitic acid-induced ferroptosis via CD36 activates ER stress to break calcium-iron balance in colon cancer cells.
Fenofibrate attenuates the cytotoxic effect of cisplatin on lung cancer cells by enhancing the antioxidant defense system in vitro.
Coffee prevents IQ-induced liver damage by regulating oxidative stress, inflammation, endoplasmic reticulum stress, autophagy, apoptosis, and the MAPK/NF-κB signaling pathway in zebrafish.
Vitamin B12 alleviates myocardial ischemia/reperfusion injury via the SIRT3/AMPK signaling pathway.
A novel organic arsenic derivative MZ2 remodels metabolism and triggers mtROS-mediated apoptosis in acute myeloid leukemia.
Dipeptidyl peptidase 3 is essential for maintaining osteoblastic differentiation under a high-glucose environment by inhibiting apoptosis, oxidative stress and inflammation through the modulation of the Keap1-Nrf2 pathway.
The protective effect of lncRNA NEAT1/miR-122-5p/Wnt1 axis on hippocampal damage in hepatic ischemic reperfusion young mice.
Hydrogen sulfide alleviates mitochondrial damage and ferroptosis by regulating OPA3-NFS1 axis in doxorubicin-induced cardiotoxicity.
Downregulated CAV-1 in mouse spinal cord may alleviate bone cancer pain by inhibiting the ERK/CREB pathway.
Defective efferocytosis by aged macrophages promotes STING signaling mediated inflammatory liver injury.
DSC2 suppresses the growth of gastric cancer through the inhibition of nuclear translocation of γ-catenin and PTEN/PI3K/AKT signaling pathway.
Design, synthesis, and SAR study of novel flavone 1,2,4-oxadiazole derivatives with anti-inflammatory activities for the treatment of Parkinson's disease.
Downregulation of CLDN6 inhibits cell migration and invasion and promotes apoptosis by regulation of the JAK2/STAT3 signaling pathway in hepatocellular carcinoma.
Effects of the Overexpression of Progesterone Receptors on a Precancer p53 and Rb-Defective Human Fallopian Tube Epithelial Cell Line.
Neuroprotective effect of a medium-chain triglyceride ketogenic diet on MPTP-induced Parkinson's disease mice: a combination of transcriptomics and metabolomics in the substantia nigra and fecal microbiome.
Alkaloids from Piper longum Exhibit Anti-inflammatory Activity and Synergistic Effects with Chemotherapeutic Agents against Cervical Cancer Cells.
Gut microbiota contribute to Methamphetamine-induced cardiotoxicity in mouse model.
Stat3 shRNA delivery with folate receptor-modified multi-functionalized graphene oxide particles for combined infrared radiation and gene therapy in hepatocellular carcinoma.
Periplocin inhibits hepatocellular carcinoma progression and reduces the recruitment of MDSCs through AKT/NF-κB pathway.
Carnosic Acid Attenuates AβOs-Induced Apoptosis and Synaptic Impairment via Regulating NMDAR2B and Its Downstream Cascades in SH-SY5Y Cells.
The hybrid oncolytic peptide NTP-385 potently inhibits adherent cancer cells by targeting the nucleus.
Anti-Postmenopausal osteoporosis effects of Isopsoralen: A bioinformatics-integrated experimental study.
6-Methoxydihydrosanguinarine induces apoptosis and autophagy in breast cancer MCF-7 cells by accumulating ROS to suppress the PI3K/AKT/mTOR signaling pathway.
Verniciflavanol A, a profisetinidin-type-4-arylflavan-3-ol from toxicodendron vernicifluum protects SH-SY5Y cells against H2O2-Induced oxidative stress.
Protective Mechanism of Ethyl Gallate against Intestinal Ischemia-Reperfusion Injury in Mice by in Vivo and in Vitro Studies Based on Transcriptomics.
CircSETD3 mediates acquired resistance to gefitinib in non-small lung cancer cells by FXR1/ECT2 pathway.
Koumine ameliorates concanavalin A-induced autoimmune hepatitis in mice: involvement of the Nrf2, NF-κB pathways, and gut microbiota.
Methyl gallate prevents oxidative stress induced apoptosis and ECM degradation in chondrocytes via restoring Sirt3 mediated autophagy and ameliorates osteoarthritis progression.
Flammulina velutipes stem regulates oxidative damage and synthesis of yolk precursors in aging laying hens by regulating the liver-blood-ovary axis.
Berberine enhances autophagic flux by activating the Nrf2 signaling pathway in bovine endometrial epithelial cells to resist LPS-induced apoptosis.
Cathepsin B mediates the lysosomal-mitochondrial apoptosis pathway in arsenic-induced microglial cell injury.
Immunopotentiation effects of apigenin on NK cell proliferation and killing pancreatic cancer cells.
Aa-Z2 triggers ROS-induced apoptosis of osteosarcoma by targeting PDK-1.
A Mulberry Diels-Alder-Type Adduct, Kuwanon M, Triggers Apoptosis and Paraptosis of Lung Cancer Cells through Inducing Endoplasmic Reticulum Stress.
Sulforaphane Suppresses H(2)O(2)-Induced Oxidative Stress and Apoptosis via the Activation of AMPK/NFE2L2 Signaling Pathway in Goat Mammary Epithelial Cells.
Deficiency of S100A9 Alleviates Sepsis-Induced Acute Liver Injury through Regulating AKT-AMPK-Dependent Mitochondrial Energy Metabolism.
Stearate-derived very long-chain fatty acids are indispensable to tumor growth.
Endosulfan induced kidney cell injury by modulating ACE2 through up-regulating miR-429 in HK-2 cells.
Design, synthesis and anti-ovarian cancer activities of thieno[2,3-d]pyrimidine based chimeric BRD4 inhibitor/nitric oxide-donator.
Discovery of rafoxanide as a novel agent for the treatment of non-small cell lung cancer.
The Importance of the Immune System and Molecular Cell Signaling Pathways in the Pathogenesis and Progression of Lung Cancer.
METTL3 Regulates Osteoclast Biological Behaviors via iNOS/NO-Mediated Mitochondrial Dysfunction in Inflammatory Conditions.
Dioscin reduced chemoresistance for colon cancer and analysis of sensitizing targets.
ALKBH5 ALLEVIATES HYPOXIA POSTCONDITIONING INJURY IN d -GALACTOSE-INDUCED SENESCENT CARDIOMYOCYTES BY REGULATING STAT3.
Aluminum exposure induces nephrotoxicity via fibrosis and apoptosis through the TGF-β1/Smads pathway in vivo and in vitro.
FSH-inhibited autophagy protects against oxidative stress in goat Sertoli cells through p62-Nrf2 pathway.
Triptonide inhibits growth and metastasis in HCC by suppressing EGFR/PI3K/AKT signaling.
Dysregulated B7H4/JAK2/STAT3 Pathway Involves in Hypertriglyceridemia Acute Pancreatitis and Is Attenuated by Baicalin.
Elevated PGT promotes proliferation and inhibits cell apoptosis in preeclampsia by Erk signaling pathway.
G2 and S phase-expressed-1 induces chromosomal instability in esophageal squamous cell carcinoma cells and inhibits cell apoptosis through ROS/JNK signaling.
Curcumin alleviates ketamine-induced oxidative stress and apoptosis via Nrf2 signaling pathway in rats' cerebral cortex and hippocampus.
Combination of a New Oral Demethylating Agent, OR2100, and Venetoclax for Treatment of Acute Myeloid Leukemia.
Combination of chloroquine diphosphate and salidroside induces human liver cell apoptosis via regulation of mitochondrial dysfunction and autophagy.
Cyasterone inhibits IL-1β-mediated apoptosis and inflammation via the NF-κB and MAPK signaling pathways in rat chondrocytes and ameliorates osteoarthritisin vivo.
The organic arsenical-derived thioredoxin and glutathione system inhibitor ACZ2 induces apoptosis and autophagy in gastric cancer via ROS-dependent ER stress.
Decreased expression and DNA hypermethylation of syncytin-1 in human villus tissues with unexplained recurrent spontaneous abortion.
Melatonin reduces IL-33 and TSLP expression in human nasal epithelial cells by scavenging ROS directly.
Low temperature exposure inhibits proliferation and induces apoptosis of bovine subcutaneous preadipocytes via p38 MAPK/JNK activation.
Combination of DNA Damage, Autophagy, and ERK Inhibition: Novel Evodiamine-Inspired Multi-Action Pt(IV) Prodrugs with High-Efficiency and Low-Toxicity Antitumor Activity.
Stress granules inhibit endoplasmic reticulum stress-mediated apoptosis during hypoxia-induced injury in acute liver failure.
Knockdown of MEF2D inhibits the development and progression of B-cell acute lymphoblastic leukemia.
LncGMDS-AS1 promotes the tumorigenesis of colorectal cancer through HuR-STAT3/Wnt axis.
The protective effect of the mitochondrial-derived peptide MOTS-c on LPS-induced septic cardiomyopathy.
A role for fibroblast-derived SASP factors in the activation of pyroptotic cell death in mammary epithelial cells.
METTL14-dependent maturation of pri-miR-17 regulates mitochondrial homeostasis and induces chemoresistance in colorectal cancer.
Iron overload modulates follicular microenvironment via ROS/HIF-1α/FSHR signaling.
Identifying CDC7 as a synergistic target of chemotherapy in resistant small-cell lung cancer via CRISPR/Cas9 screening.
RTA dh404 Induces Cell Cycle Arrest, Apoptosis, and Autophagy in Glioblastoma Cells.
Exendin-4 alleviates myocardial ischemia reperfusion injury by enhancing autophagy through promoting nuclear translocation of TFEB.
To explore the regulatory role of Wnt/P53/Caspase3 signal in mouse ovarian development based on LFQ proteomics.
Bumetanide Rescues Aquaporin-4 Depolarization via Suppressing β-Dystroglycan Cleavage and Provides Neuroprotection in Rat Retinal Ischemia-Reperfusion Injury.
Long noncoding RNA RMRP ameliorates doxorubicin-induced apoptosis by interacting with PFN1 in a P53-Dependent manner.
TBC1 domain family member 25 protects against myocardial apoptosis and the proinflammatory response triggered by ischemia-reperfusion injury through suppression of the TAK1-JNK/p38 MAPK signaling cascade.
Selumetinib overcomes gefitinib primary and acquired resistance by regulating MIG6/STAT3 in NSCLC.
ANXA3, associated with YAP1 regulation, participates in the proliferation and chemoresistance of cervical cancer cells.
Integrating network pharmacology and experimental models to examine the mechanisms of corosolic acid in preventing hepatocellular carcinoma progression through activation PERK-eIF2a-ATF4 signaling.
GALNT2, an O-glycosylating enzyme, is a critical regulator of radioresistance of non-small cell lung cancer: evidence from an integrated multi-omics analysis.
Endogenous hydrogen sulfide inhibition suppresses tumor growth by promoting apoptosis and pyroptosis in esophageal cancer cells.
miR-133a-3p regulates the growth of hair follicle stem cells in white goats from the Yangtze River Delta.
Bioinformatic analysis of the expression profile and identification of RhoGDI2 as a biomarker in imatinib-resistant K562 cells.
BNIP3 overexpression may promote myeloma cell apoptosis by enhancing sensitivity to bortezomib via the p38 MAPK pathway.
Brusatol enhances MEF2A expression to inhibit RCC progression through the Wnt signalling pathway in renal cell carcinoma.
Inhibiting NF-κB-S100A11 signaling and targeting S100A11 for anticancer effects of demethylzeylasteral in human colon cancer.
LRRC8A promotes Glaesserella parasuis cytolethal distending toxin-induced p53-dependent apoptosis in NPTr cells.
The novel CDK9 inhibitor, XPW1, alone and in combination with BRD4 inhibitor JQ1, for the treatment of clear cell renal cell carcinoma.
Multi-omics analysis reveals the mechanism of action of ophiopogonin D against pulmonary fibrosis.
Comprehensive analysis of clinical prognosis and biological significance of CNIH4 in cervical cancer.
Probiotic-fermented Qushi decoction alleviates reserpine-induced spleen deficiency syndrome by regulating spleen function and gut microbiota dysbiosis.
RUNX1 knockdown induced apoptosis and impaired EMT in high-grade serous ovarian cancer cells.
Pinocembrin attenuates susceptibility to atrial fibrillation in rats with pulmonary arterial hypertension.
Discovery of 4-((3,4-dichlorophenyl)amino)-2-methylquinolin-6-ol derivatives as EGFR and HDAC dual inhibitors.
Cynanchum komarovii extract for the treatment of rheumatoid arthritis by acting on synovial cells in vitro and in vivo.
Design, synthesis, and biological evaluation of novel 4,4'-bipyridine derivatives acting as CDK9-Cyclin T1 protein-protein interaction inhibitors against triple-negative breast cancer.
Protective Effect of Ginsenoside CK against Autoimmune Hepatitis Induced by Concanavalin A.
TrxR/Trx inhibitor butaselen ameliorates pulmonary fibrosis by suppressing NF-κB/TGF-β1/Smads signaling.
Isoliquiritigenin Inhibits the Growth of Colorectal Cancer Cells through the ESR2/PI3K/AKT Signalling Pathway.
Nanointegrative In Situ Reprogramming of Tumor-Intrinsic Lipid Droplet Biogenesis for Low-Dose Radiation-Activated Ferroptosis Immunotherapy.
Reduced Proteolipid Protein 2 promotes endoplasmic reticulum stress-related apoptosis and increases drug sensitivity in acute myeloid leukemia.
Pectolinarigenin attenuates hepatic ischemia/reperfusion injury via activation of the PI3K/AKT/Nrf2 signaling pathway.
Mouth breathing induces condylar remodelling and chondrocyte apoptosis via both the extrinsic and mitochondrial pathways in male adolescent rats.
TAGLN2 Promotes the Proliferation, Migration, Invasion, and EMT of Clear Cell Renal Cell Carcinoma Through the PI3K/Akt Signaling Pathway.
Mechanism of ligusticum cycloprolactam against neuroinflammation based on network pharmacology and experimental verification.
The MyD88 inhibitor, ST2825, induces cell cycle arrest and apoptosis by suppressing the activation of the NF‑κB/AKT1/p21 pathway in pancreatic cancer.
TRAF6 regulates autophagy and apoptosis of melanoma cells through c-Jun/ATG16L2 signaling pathway.
Methylseleninic acid induces apoptosis of human bladder cancer cells through the ROS-mediated mitochondrial pathway.
A novel long noncoding RNA-lncRNA-AABR07066529.3 alleviates inflammation, apoptosis, and pyroptosis by inhibiting MyD88 in lipopolysaccharide-induced myocardial depression.
Thymoquinone induces apoptosis and protective autophagy in gastric cancer cells by inhibiting the PI3K/Akt/mTOR pathway.
miR-101-5p overexpression suppresses the proliferation of goat spermatogonial stem cells by targeting EZH2.
Decreased PPP1R3G in pre-eclampsia impairs human trophoblast invasion and migration via Akt/MMP-9 signaling pathway.
Role of Autophagy and Apoptosis in Aluminum Exposure-Induced Liver Injury in Rats.
Profilin1 Regulates Trophoblast Invasion and Macrophage Differentiation.
Armcx1 attenuates secondary brain injury in an experimental traumatic brain injury model in male mice by alleviating mitochondrial dysfunction and neuronal cell death.
MALAT1 binds to miR-188-3p to regulate ALOX5 activity in the lung inflammatory response of neonatal bronchopulmonary dysplasia.
Astragaloside IV protects LO2 cells from oxidative damage caused by radiation-induced bystander effect through Akt/Nrf2 pathway.
Multi-Catcher Polymers Regulate the Nucleolin Cluster on the Cell Surface for Cancer Therapy.
Manganese-induced apoptosis through the ROS-activated JNK/FOXO3a signaling pathway in CTX cells, a model of rat astrocytes.
Histone acetylation by HBO1 (KAT7) activates Wnt/β-catenin signaling to promote leukemogenesis in B-cell acute lymphoblastic leukemia.
Cordycepin inhibits ERK pathway to suppress FGF9-induced tumorigenesis with MA-10 mouse Leydig tumor cells.
Free Fatty Acids Induce Apoptosis of Mammary Epithelial Cells of Ketotic Dairy Cows via the Mito-ROS/NLRP3 Signaling Pathway.
The cellular uptake of Cordyceps sinensis exopolysaccharide‑selenium nanoparticles and their induced apoptosis of HepG2 cells via mitochondria- and death receptor-mediated pathways.
Neuroprotective Effects of Vinpocetine Against Ischemia-Reperfusion Injury Via Inhibiting NLRP3 Inflammasome Signaling Pathway.
MFAP2 promotes the progression of oral squamous cell carcinoma by activating the Wnt/β-catenin signaling pathway through autophagy.
ADAMDEC1 induces EMT and promotes colorectal cancer cells metastasis by enhancing Wnt/β-catenin signaling via negative modulation of GSK-3β.
Salidroside alleviates acetaminophen-induced hepatotoxicity via Sirt1-mediated activation of Akt/Nrf2 pathway and suppression of NF-κB/NLRP3 inflammasome axis.
Correction: Tang et al. Vitamin K2 Modulates Mitochondrial Dysfunction Induced by 6-Hydroxydopamine in SH-SY5Y Cells via Mitochondrial Quality-Control Loop. Nutrients 2022, 14, 1504.
Intermittent fasting activates macrophage migration inhibitory factor and alleviates high-fat diet-induced nonalcoholic fatty liver disease.
Ubiquitin-specific protease 7 prevents recurrent spontaneous abortion by targeting enhancer of zeste homolog 2 to regulate trophoblast proliferation, apoptosis, migration, and invasion through the Wnt/β-catenin pathway†.
The effects and mechanism of LncRNA NORAD on doxorubicin-induced cardiotoxicity.
Mechanism of aconitine mediated neuronal apoptosis induced by mitochondrial calcium overload caused by MCU.
Combination with vorinostat enhances the antitumor activity of cisplatin in castration-resistant prostate cancer by inhibiting DNA damage repair pathway and detoxification of GSH.
RBM3 is associated with acute lung injury in septic mice and patients via the NF-κB/NLRP3 pathway.
Synergistic activity and mechanism of cytarabine and MCL-1 inhibitor AZD5991 against acute myeloid leukemia.
NUCKS1 promotes the progression of colorectal cancer via activating PI3K/AKT/mTOR signaling pathway.
Alpha-ketoglutarate ameliorates induced premature ovarian insufficiency in rats by inhibiting apoptosis and upregulating glycolysis.
Hederagenin Suppresses Inflammation and Cartilage Degradation to Ameliorate the Progression of Osteoarthritis: An In vivo and In vitro Study.
Oridonin ameliorates caspase-9-mediated brain neuronal apoptosis in mouse with ischemic stroke by inhibiting RIPK3-mediated mitophagy.
Relaxin-2 Prevents Erectile Dysfunction by Cavernous Nerve, Endothelial and Histopathological Protection Effects in Rats with Bilateral Cavernous Nerve Injury.
Decreased autophagic activity of detrusor cells is involved in the inflammatory response of interstitial cystitis/bladder pain syndrome.
Parecoxib attenuates inflammation injury in septic H9c2 cells by regulating the MAPK signaling pathway.
A prospective diagnostic and prognostic biomarker for hepatocellular carcinoma that functions in glucose metabolism regulation: Solute carrier family 37 member 3.
Roles of TRPV4 in Regulating Circulating Angiogenic Cells to Promote Coronary Microvascular Regeneration.
Dual-specificity phosphatase 26-dificient neurons are susceptible to oxygen-glucose deprivation/reoxygenation-evoked apoptosis and proinflammatory response by affecting the TAK1-medaited JNK/P38 MAPK pathway.
Circular RNA circ0104103 inhibits colorectal cancer progression through interactions with HuR and miR-373-5p.
Exercise-activated hepatic autophagy via the FN1-α5β1 integrin pathway drives metabolic benefits of exercise.
Diosgenin Inhibits ROS Generation by Modulating NOX4 and Mitochondrial Respiratory Chain and Suppresses Apoptosis in Diabetic Nephropathy.
NCAPG is transcriptionally regulated by CBX3 and activates the Wnt/β-catenin signaling pathway to promote proliferation and the cell cycle and inhibit apoptosis in colorectal cancer.
Dual role of PID1 in regulating apoptosis induced by distinct anticancer-agents through AKT/Raf-1-dependent pathway in hepatocellular carcinoma.
Acinous cell AR42J-derived exosome miR125b-5p promotes acute pancreatitis exacerbation by inhibiting M2 macrophage polarization via PI3K/AKT signaling pathway.
An herbal formulation "Shenshuaifu Granule" alleviates cisplatin-induced nephrotoxicity by suppressing inflammation and apoptosis through inhibition of the TLR4/MyD88/NF-κB pathway.
Administration of prosaposin-derived neurotrophic factor to neural tube defects facilitates regeneration and restores neurological functions.
Melatonin induces cell cycle arrest and suppresses tumor invasion in urinary bladder urothelial carcinoma.
[Overexpression of miR-431-5p impairs mitochondrial function and induces apoptosis in gastric cancer cells via the Bax/Bcl-2/caspase3 pathway].
Antioxidant, Immunostimulatory, and Anticancer Properties of Hydrolyzed Wheat Bran Mediated through Macrophages Stimulation.
Disruption of the Intestinal Mucosal Barrier Induced by High Fructose and Restraint Stress Is Regulated by the Intestinal Microbiota and Microbiota Metabolites.
OBHS Drives Abnormal Glycometabolis Reprogramming via GLUT1 in Breast Cancer.
Sulforaphane suppresses paraquat-induced oxidative damage in bovine in vitro-matured oocytes through Nrf2 transduction pathway.
Renal Ischemia-reperfusion Injury Attenuated by Exosomes Extracted From Splenic Ischemic Preconditioning Models.
Aerobic Exercise Training Improves Renal Injury in Spontaneously Hypertensive Rats by Increasing Renalase Expression in Medulla.
Effect of Two Different Drug-Resistant Staphylococcus aureus Strains on the Physiological Properties of MAC-T Cells and Their Transcriptome Analysis.
Integrated Strategies of Diverse Feature Selection Methods Identify Aging-Based Reliable Gene Signatures for Ischemic Cardiomyopathy.
1,4-dihydroxy quininib modulates the secretome of uveal melanoma tumour explants and a marker of oxidative phosphorylation in a metastatic xenograft model.
TRIM47 promotes ovarian cancer cell proliferation, migration, and invasion by activating STAT3 signaling.
Antitumor Effects of Astaxanthin on Esophageal Squamous Cell Carcinoma by up-Regulation of PPARγ.
MiR-7015-3p Targets Nuclear Factor-Kappa-B-Inhibitor Alpha to Aggravate Hypoxia/Reoxygenation Injury in Cardiomyocytes Through the NF-κB Pathway.
Effect of one-time high load exercise on skeletal muscle injury in rats of different genders: oxidative stress and mitochondrial responses.
Jatrorrhizine reduces myocardial infarction-induced apoptosis and fibrosis through inhibiting p53 and TGF-β1/Smad2/3 pathways in mice.
Guanxinping Tablets Inhibit ET-1-Induced Proliferation and Migration of MOVAS by Suppressing Activated PI3K/Akt/NF-κB Signaling Cascade.
A Network Pharmacology Approach for Uncovering the Antitumor Effects and Potential Mechanisms of the Sijunzi Decoction for the Treatment of Gastric Cancer.
Study on the Anti-demyelination Mechanism of Bu-Shen-Yi-Sui Capsule in the Central Nervous System Based on Network Pharmacology and Experimental Verification.
PHGDH Inhibitor CBR-5884 Inhibits Epithelial Ovarian Cancer Progression via ROS/Wnt/β-Catenin Pathway and Plays a Synergistic Role with PARP Inhibitor Olaparib.
Development of a Costimulatory Molecule Signature to Predict Prognosis, Immune Landscape, and Response to Immune Therapy for Hepatocellular Carcinoma.
Loureirin A Exerts Antikeloid Activity by Antagonizing the TGF-β1/Smad Signalling Pathway.
Pretreatment with Shenmai Injection Protects against Coronary Microvascular Dysfunction.
Resveratrol Induces Apoptosis, Suppresses Migration, and Invasion of Cervical Cancer Cells by Inhibiting the Hedgehog Signaling Pathway.
Protective Effect of Phloretin against Hydrogen Peroxide-Induced Oxidative Damage by Enhancing Autophagic Flux in DF-1 Cells.
Keratin 8 Is an Inflammation-Induced and Prognosis-Related Marker for Pancreatic Adenocarcinoma.
EGCG Enhances the Chemosensitivity of Colorectal Cancer to Irinotecan through GRP78-MediatedEndoplasmic Reticulum Stress.
Resveratrol Downregulates miR-155-5p to Block the Malignant Behavior of Gastric Cancer Cells.
Correlation Analysis of Umbilical Cord Blood Metabolic Phenotype and Inflammation in Patients with Gestational Diabetes Mellitus Complicated with Overweight and Obesity.
Metformin Exhibits an Attractive Antineoplastic Effect on Human Endometrial Cancer by Regulating the Hippo Signaling Pathway.
Schisandrin B Diet Inhibits Oxidative Stress to Reduce Ferroptosis and Lipid Peroxidation to Prevent Pirarubicin-Induced Hepatotoxicity.
LARS2 Regulates Apoptosis via ROS-Mediated Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in Ovarian Granulosa Cells.
The Effects of Hedgehog Signaling Pathway on the Proliferation and Apoptosis of Melanoma Cells.
Evodiamine as the Active Compound of Evodiae fructus to Inhibit Proliferation and Migration of Prostate Cancer through PI3K/AKT/NF-κB Signaling Pathway.
The lncRNA KIF9-AS1 Accelerates Hepatocellular Carcinoma Growth by Recruiting DNMT1 to Promote RAI2 DNA Methylation.
Prognostic Lnc-S100B-2 Affects Cell Apoptosis and Microenvironment of Colorectal Cancer through MLLT10 Signaling.
p16(INK4a) Plays Critical Role in Exacerbating Inflammaging in High Fat Diet Induced Skin.
Hax-1 Regulates Radiation-Induced Mitochondrial-Dependent Apoptosis of Uveal Melanoma Cells through PI3K/AKT/eNOS Pathway.
Mechanism Study of Cinnamomi Ramulus and Paris polyphylla Sm. Drug Pair in the Treatment of Adenomyosis by Network Pharmacology and Experimental Validation.
Grape Seed Proanthocyanidins Exert a Neuroprotective Effect by Regulating Microglial M1/M2 Polarisation in Rats with Spinal Cord Injury.
DJ-1/FGFR-1 Signaling Pathway Contributes to Sorafenib Resistance in Hepatocellular Carcinoma.
Oleoylethanolamide Alleviates Hepatic Ischemia-Reperfusion Injury via Inhibiting Endoplasmic Reticulum Stress-Associated Apoptosis.
Sestrin2 Overexpression Ameliorates Endoplasmic Reticulum Stress-Induced Apoptosis via Inhibiting mTOR Pathway in HepG2 Cells.
Overexpression of Aquaporin-3 Alleviates Hyperosmolarity-Induced Nucleus Pulposus Cell Apoptosis via Regulating the ERK1/2 Pathway.
PCNP is a novel regulator of proliferation, migration, and invasion in human thyroid cancer.
A marine-derived small molecule induces immunogenic cell death against triple-negative breast cancer through ER stress-CHOP pathway.
Yap is essential for uterine decidualization through Rrm2/GSH/ROS pathway in response to Bmp2.
HJURP Promotes Malignant Progression and Mediates Sensitivity to Cisplatin and WEE1-inhibitor in Serous Ovarian Cancer.
Dezocine inhibits cell proliferation, migration, and invasion by targeting CRABP2 in ovarian cancer.
Ketamine Attenuates Airway Inflammation via Inducing Inflammatory Cells Apoptosis and Activating Nrf2 Pathway in a Mixed-Granulocytic Murine Asthma Model.
Keloid Patient Plasma-Derived Exosomal hsa_circ_0020792 Promotes Normal Skin Fibroblasts Proliferation, Migration, and Fibrogenesis via Modulating miR-193a-5p and Activating TGF-β1/Smad2/3 Signaling.
Feasibility of Catalpol Intranasal Administration and Its Protective Effect on Acute Cerebral Ischemia in Rats via Anti-Oxidative and Anti-Apoptotic Mechanisms.
Magnesium Lithospermate B Protects Against Cisplatin-Induced Acute Kidney Injury via Alleviating Mitochondrial Dysfunction.
Didymin Ameliorates Liver Fibrosis by Alleviating Endoplasmic Reticulum Stress and Glycerophospholipid Metabolism: Based on Transcriptomics and Metabolomics.
Shikonin Attenuates Cochlear Spiral Ganglion Neuron Degeneration by Activating Nrf2-ARE Signaling Pathway.
Inhibitory effect of taurine on rotator cuff degeneration via mitochondrial protection.
Mannan-Binding Lectin via Interaction With Cell Surface Calreticulin Promotes Senescence of Activated Hepatic Stellate Cells to Limit Liver Fibrosis Progression.
Exploring the pharmacological mechanisms of icaritin against nasopharyngeal carcinoma via network pharmacology and experimental validation.
NRF2-directed PRPS1 upregulation to promote the progression and metastasis of melanoma.
Alleviating effect of quercetin on cadmium-induced oxidative damage and apoptosis by activating the Nrf2-keap1 pathway in BRL-3A cells.
The miR-33a-5p/CROT axis mediates ovarian cancer cell behaviors and chemoresistance via the regulation of the TGF-β signal pathway.
D-tagatose protects against oleic acid-induced acute respiratory distress syndrome in rats by activating PTEN/PI3K/AKT pathway.
Acetyl-11-Keto-Beta Boswellic Acid (AKBA) Protects Lens Epithelial Cells Against H(2)O(2)-Induced Oxidative Injury and Attenuates Cataract Progression by Activating Keap1/Nrf2/HO-1 Signaling.
Furfural Produces Dose-Dependent Attenuating Effects on Ethanol-Induced Toxicity in the Liver.
ABCA12 Promotes Proliferation and Migration and Inhibits Apoptosis of Pancreatic Cancer Cells Through the AKT Signaling Pathway.
Interleukin-6-derived cancer-associated fibroblasts activate STAT3 pathway contributing to gemcitabine resistance in cholangiocarcinoma.
Autophagy Inhibition Enhances the Anti-Tumor Activity of Methylseleninic Acid in Cisplatin-Resistance Human Lung Adenocarcinoma Cells.
FGF2 Is Protective Towards Cisplatin-Induced KGN Cell Toxicity by Promoting FTO Expression and Autophagy.
Engineered Exosomes-Mediated Transfer of hsa-miR-320a Overcomes Chemoresistance in Cervical Cancer Cells via Targeting MCL1.
High expression of B4GALT1 is associated with poor prognosis in acute myeloid leukemia.
H1N1 Influenza Virus-Infected Nasal Mucosal Epithelial Progenitor Cells Promote Dendritic Cell Recruitment and Maturation.
Dimethyl Fumarate Ameliorates Doxorubicin-Induced Cardiotoxicity By Activating the Nrf2 Pathway.
Cytosolic p53 Inhibits Parkin-Mediated Mitophagy and Promotes Acute Liver Injury Induced by Heat Stroke.
Gluconolactone Alleviates Myocardial Ischemia/Reperfusion Injury and Arrhythmias via Activating PKCε/Extracellular Signal-Regulated Kinase Signaling.
Silibinin Therapy Improves Cholangiocarcinoma Outcomes by Regulating ERK/Mitochondrial Pathway.
Identification and Validation of Ferroptosis-Related Biomarkers in Septic Cardiomyopathy via Bioinformatics Analysis.
Tormentic Acid Ameliorates Hepatic Fibrosis in vivo by Inhibiting Glycerophospholipids Metabolism and PI3K/Akt/mTOR and NF-κB Pathways: Based on Transcriptomics and Metabolomics.
Natural product manoalide promotes EGFR-TKI sensitivity of lung cancer cells by KRAS-ERK pathway and mitochondrial Ca(2+) overload-induced ferroptosis.
Corilagin alleviates intestinal ischemia/reperfusion-induced intestinal and lung injury in mice via inhibiting NLRP3 inflammasome activation and pyroptosis.
Malvidin alleviates mitochondrial dysfunction and ROS accumulation through activating AMPK-α/UCP2 axis, thereby resisting inflammation and apoptosis in SAE mice.
Bisphenols A and F, but not S, induce apoptosis in bovine granulosa cells via the intrinsic mitochondrial pathway.
Ginkgolide C slows the progression of osteoarthritis by activating Nrf2/HO-1 and blocking the NF-κB pathway.
BCATc inhibitor 2 ameliorated mitochondrial dysfunction and apoptosis in oleic acid-induced non-alcoholic fatty liver disease model.
Network pharmacology-based and experimental identification of the effects of Renshen Yangrong decoction on myocardial infarction.
METTL3/m(6)A/IFIT2 regulates proliferation, invasion and immunity in esophageal squamous cell carcinoma.
Cordycepin enhances radiosensitivity to induce apoptosis through cell cycle arrest, caspase pathway and ER stress in MA-10 mouse Leydig tumor cells.
INPP4B inhibits glioma cell proliferation and immune escape via inhibition of the PI3K/AKT signaling pathway.
The Novel lncRNA RP9P Promotes Colorectal Cancer Progression by Modulating miR-133a-3p/FOXQ1 Axis.
Hinokiflavone Inhibits Growth of Esophageal Squamous Cancer By Inducing Apoptosis via Regulation of the PI3K/AKT/mTOR Signaling Pathway.
Fusobacterium necrophorum Promotes Apoptosis and Inflammatory Cytokine Production Through the Activation of NF-κB and Death Receptor Signaling Pathways.
Prognostic biomarker MCP-4 triggers epithelial-mesenchymal transition via the p38 MAPK pathway in ovarian cancer.
Sophocarpine inhibits tumor progression by antagonizing the PI3K/AKT/mTOR signaling pathway in castration-resistant prostate cancer.
Glucocorticoids induce osteonecrosis of the femoral head in rats via PI3K/AKT/FOXO1 signaling pathway.
Protection of catalpol against triptolide-induced hepatotoxicity by inhibiting excessive autophagy via the PERK-ATF4-CHOP pathway.
Therapeutic targeting of ARID1A and PI3K/AKT pathway alterations in cholangiocarcinoma.
A nanobody-based molecular toolkit for ubiquitin-proteasome system explores the main role of survivin subcellular localization.
Dexamethasone Alleviates Myocardial Injury in a Rat Model of Acute Myocardial Infarction Supported by Venoarterial Extracorporeal Membrane Oxygenation.
The Circular RNA CircCOL1A1 Functions as a miR-149-5p Sponge to Regulate the Formation of Superior-Quality Brush Hair via the CMTM3/AR Axis.
TMPRSS12 Functions in Meiosis and Spermiogenesis and Is Required for Male Fertility in Mice.
A bavachinin analog, D36, induces cell death by targeting both autophagy and apoptosis pathway in acute myeloid leukemia cells.
Effect of thymoquinone on sepsis-induced cardiac damage via anti-inflammatory and anti-apoptotic mechanisms.
Ginsenoside Rg3 increases gemcitabine sensitivity of pancreatic adenocarcinoma via reducing ZFP91 mediated TSPYL2 destabilization.
Protective Effect of Shenfu Injection on Vascular Endothelial Damage in a Porcine Model of Hemorrhagic Shock.
UFL1 alleviates ER stress and apoptosis stimulated by LPS via blocking the ferroptosis pathway in human granulosa-like cells.
Suppression of EZH2 inhibits TGF-β1-induced EMT in human retinal pigment epithelial cells.
Inhibition of 8-oxoguanine DNA glycosylase (OGG1) expression suppresses polycystic ovarian syndrome via the NF-κB signaling pathway.
Discoidin domain receptor 1(DDR1) promote intestinal barrier disruption in Ulcerative Colitis through tight junction proteins degradation and epithelium apoptosis.
Design, semi-synthesis and bioactivity evaluation of novel podophyllotoxin derivatives as potent anti-tumor agents.
N-Acetyl-l-tryptophan inhibits CCl(4)-induced hepatic fibrogenesis via regulating TGF-β1/SMAD and Hippo/YAP1 signal.
MiR-1306-5p promotes cell proliferation and inhibits cell apoptosis in acute myeloid leukemia by downregulating PHF6 expression.
Chlorogenic acid suppresses miR-460a in the regulation of Bcl-2, causing interleukin-1β reduction in thiram exposed chondrocytes via caspase-3/caspase-7 pathway.
GTSE1 promotes tumor growth and metastasis by attenuating of KLF4 expression in clear cell renal cell carcinoma.
TRIM36 inhibits tumorigenesis through the Wnt/β-catenin pathway and promotes caspase-dependent apoptosis in hepatocellular carcinoma.
METTL3 suppresses anlotinib sensitivity by regulating m(6)A modification of FGFR3 in oral squamous cell carcinoma.
HOXA5 inhibits the proliferation of extrahepatic cholangiocarcinoma cells by enhancing MXD1 expression and activating the p53 pathway.
Small extracellular vesicles of hypoxic endothelial cells regulate the therapeutic potential of adipose-derived mesenchymal stem cells via miR-486-5p/PTEN in a limb ischemia model.
Taraxasterol Inhibits Tumor Growth by Inducing Apoptosis and Modulating the Tumor Microenvironment in Non-Small Cell Lung Cancer.
Co-Targeting ErbB Receptors and the PI3K/AKT Axis in Androgen-Independent Taxane-Sensitive and Taxane-Resistant Human Prostate Cancer Cells.
Daidzein alleviates doxorubicin-induced heart failure via the SIRT3/FOXO3a signaling pathway.
Isoalantolactone (IAL) Regulates Neuro-Inflammation and Neuronal Apoptosis to Curb Pathology of Parkinson's Disease.
Zearalenone Promotes LPS-Induced Oxidative Stress, Endoplasmic Reticulum Stress, and Accelerates Bovine Mammary Epithelial Cell Apoptosis.
Chronic acrylamide exposure resulted in dopaminergic neuron loss, neuroinflammation and motor impairment in rats.
Neuropeptide-Functionalized Gold Nanorod Enhanced Cellular Uptake and Improved In Vitro Photothermal Killing in LRP1-Positive Glioma Cells.
Comprehensive comparison between azacytidine and decitabine treatment in an acute myeloid leukemia cell line.
1-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)-3-(2-(dimethylamino)ethyl)imidazolidin-2-one (ZX-42) inhibits cell proliferation and induces apoptosis via inhibiting ALK and its downstream pathways in Karpas299 cells.
LIS1 interacts with CLIP170 to promote tumor growth and metastasis via the Cdc42 signaling pathway in salivary gland adenoid cystic carcinoma.
Hace1 overexpression mitigates myocardial hypoxia/reoxygenation injury via the effects on Keap1/Nrf2 pathway.
TMBIM6 promotes diabetic tubular epithelial cell survival and albumin endocytosis by inhibiting the endoplasmic reticulum stress sensor, IRE1α.
PLEK2 promotes cancer stemness and tumorigenesis of head and neck squamous cell carcinoma via the c-Myc-mediated positive feedback loop.
Bortezomib prodrug catalytic nanoreactor for chemo/chemodynamic therapy and macrophage re-education.
Transcription factor YY1 contributes to human melanoma cell growth through modulating the p53 signalling pathway.
Mechanical stretch aggravates vascular smooth muscle cell apoptosis and vascular remodeling by downregulating EZH2.
Aucubin promoted neuron functional recovery by suppressing inflammation and neuronal apoptosis in a spinal cord injury model.
Chicoric acid attenuates tumor necrosis factor-α-induced inflammation and apoptosis via the Nrf2/HO-1, PI3K/AKT and NF-κB signaling pathways in C28/I2 cells and ameliorates the progression of osteoarthritis in a rat model.
Exosomes Derived from Bone Marrow Mesenchymal Stem Cells Alleviate Ischemia-Reperfusion Injury and Promote Survival of Skin Flaps in Rats.
UBXD8 mediates mitochondria-associated degradation to restrain apoptosis and mitophagy.
Regulation of Proliferation and Apoptosis of Hair Follicle Stem Cells by miR-145-5p in Yangtze River Delta White Goats.
DNMT3A R882H mutation drives daunorubicin resistance in acute myeloid leukemia via regulating NRF2/NQO1 pathway.
Valdecoxib Protects against Cell Apoptosis Induced by Endoplasmic Reticulum Stress via the Inhibition of PERK-ATF4-CHOP Pathway in Experimental Glaucoma.
Metformin alleviates bone loss in ovariectomized mice through inhibition of autophagy of osteoclast precursors mediated by E2F1.
Network Pharmacology Analysis and Experimental Validation of Kaempferol in the Treatment of Ischemic Stroke by Inhibiting Apoptosis and Regulating Neuroinflammation Involving Neutrophils.
Polygonatum cyrtonema Hua Polysaccharides Protect BV2 Microglia Relief Oxidative Stress and Ferroptosis by Regulating NRF2/HO-1 Pathway.
MicroRNA-21-5p agomir inhibits apoptosis of oligodendrocyte precursor cell and attenuates white matter injury in neonatal rats.
Anti-ANGPTL3-FLD monoclonal antibody treatment ameliorates podocyte lesions through attenuating mitochondrial damage.
Difenoconazole disrupts the blood-brain barrier and results in neurotoxicity in carp by inhibiting the Nrf2 pathway mediated ROS accumulation.
miR-1297 sensitizes glioma cells to temozolomide (TMZ) treatment through targeting adrenomedullin (ADM).
Protective effect of hepatocyte-enriched lncRNA-Mir122hg by promoting hepatocyte proliferation in acute liver injury.
An oleanolic acid derivative, K73-03, inhibits pancreatic cancer cells proliferation in vitro and in vivo via blocking EGFR/Akt pathway.
S100A8 regulates autophagy-dependent ferroptosis in microglia after experimental subarachnoid hemorrhage.
Targeting the miR-34a/LRPPRC/MDR1 axis collapse the chemoresistance in P53 inactive colorectal cancer.
Legumain affects the PI3K/AKT tumor progression pathway in retinoblastoma.
N-acetylserotonin protects PC12 cells from hydrogen peroxide induced damage through ROS mediated PI3K / AKT pathway.
Effect of rapamycin treatment on oocyte in vitro maturation and embryonic development after parthenogenesis in yaks.
Ellagic Acid Alleviates Mice Intestinal Ischemia-Reperfusion Injury: A Study Based on Transcriptomics Combined with Functional Experiments.
5-Bromo-3,4-dihydroxybenzaldehyde attenuates endothelial cells injury from high glucose-induced damage.
Diterpenoids from the whole plant of Euphorbia wallichii and their protective effects on H(2)O(2)-induced BV-2 microglial cells injury.
Novel isatin-based hybrids as potential anti-rheumatoid arthritis drug candidates: Synthesis and biological evaluation.
Long-Term Consumption of Food-Derived Chlorogenic Acid Protects Mice against Acetaminophen-Induced Hepatotoxicity via Promoting PINK1-Dependent Mitophagy and Inhibiting Apoptosis.
GRP75 Modulates Endoplasmic Reticulum-Mitochondria Coupling and Accelerates Ca(2+)-Dependent Endothelial Cell Apoptosis in Diabetic Retinopathy.
Ellagic acid attenuates muscle atrophy in STZ-induced diabetic mice.
Suffruticosol C-Mediated Autophagy and Cell Cycle Arrest via Inhibition of mTORC1 Signaling.
WY-14643 attenuates lipid deposition via activation of the PPARα/CPT1A axis by targeting Gly335 to inhibit cell proliferation and migration in ccRCC.
CD93 promotes acute myeloid leukemia development and is a potential therapeutic target.
Inhibition of human peptide deformylase by actinonin sensitizes glioblastoma cells to temozolomide chemotherapy.
GRP94 Inhabits the Immortalized Porcine Hepatic Stellate Cells Apoptosis under Endoplasmic Reticulum Stress through Modulating the Expression of IGF-1 and Ubiquitin.
Protective Effect of Flavonoids against Methylglyoxal-Induced Oxidative Stress in PC-12 Neuroblastoma Cells and Its Structure-Activity Relationships.
NAP1L5 targeting combined with MYH9 Inhibit HCC progression through PI3K/AKT/mTOR signaling pathway.
HA-ADT suppresses esophageal squamous cell carcinoma progression via apoptosis promotion and autophagy inhibition.
Traditional Chinese medicine CFF-1 exerts a potent anti-tumor immunity to hinder tumor growth and metastasis in prostate cancer through EGFR/JAK1/STAT3 pathway to inhibit PD-1/PD-L1 checkpoint signaling.
Maslinic Acid Inhibits Myocardial Ischemia-Reperfusion Injury-Induced Apoptosis and Necroptosis via Promoting Autophagic Flux.
HSP90-Mediates Liraglutide Preconditioning-Induced Cardioprotection by Inhibiting C5a and NF-κB.
TMBIM1 promotes proliferation and attenuates apoptosis in glioblastoma cells by targeting the p38 MAPK signalling pathway.
A novel ribosomal protein S6 kinase 2 inhibitor attenuates the malignant phenotype of cutaneous malignant melanoma cells by inducing cell cycle arrest and apoptosis.
MicroRNA-124 modulates neuroinflammation in acute methanol poisoning rats via targeting Krüppel-like factor-6.
Long non-coding RNA lincRNA-erythroid prosurvival (EPS) alleviates cerebral ischemia/reperfusion injury by maintaining high-temperature requirement protein A1 (Htra1) stability through recruiting heterogeneous nuclear ribonucleoprotein L (HNRNPL).
Recombinant human klotho protects against hydrogen peroxide-mediated injury in human retinal pigment epithelial cells via the PI3K/Akt-Nrf2/HO-1 signaling pathway.
Single-cell profiling-guided combination therapy of c-Fos and histone deacetylase inhibitors in diffuse large B-cell lymphoma.
Mitochondria-specific peptide amphiphiles induce mitochondrial dysfunction and peripheral T-cell lymphomas (PTCL) damage.
Glucolipotoxicity induces endothelial cell dysfunction by activating autophagy and inhibiting autophagic flow.
Liver Receptor homolog-1 Regulates Apoptosis of Bovine Ovarian Granulosa Cells by Progestogen Receptor Signaling Pathway.
Therapeutic targeting m6A-guided miR-146a-5p signaling contributes to the melittin-induced selective suppression of bladder cancer.
FBXW2 inhibits prostate cancer proliferation and metastasis via promoting EGFR ubiquitylation and degradation.
Taraxasterol prompted the anti-tumor effect in mice burden hepatocellular carcinoma by regulating T lymphocytes.
TMCO1 expression promotes cell proliferation and induces epithelial-mesenchymal transformation in human gliomas.
Xiao-Luo-Wan treats propylthiouracil-induced goiter with hypothyroidism in rats through the PI3K-AKT/RAS pathways based on UPLC/MS and network pharmacology.
Network pharmacology analysis uncovers the effect on apoptotic pathway by Bu-Fei formula for COPD treatment.
PACS-2 Ameliorates Tubular Injury by Facilitating Endoplasmic Reticulum-Mitochondria Contact and Mitophagy in Diabetic Nephropathy.
DT7 peptide-modified lecithin nanoparticles co-loaded with γ-secretase inhibitor and dexamethasone efficiently inhibit T-cell acute lymphoblastic leukemia and reduce gastrointestinal toxicity.
Aberrant translation regulated by METTL1/WDR4-mediated tRNA N7-methylguanosine modification drives head and neck squamous cell carcinoma progression.
The LncRNA RP11-301G19.1/miR-582-5p/HMGB2 axis modulates the proliferation and apoptosis of multiple myeloma cancer cells via the PI3K/AKT signalling pathway.
Map, but not EspF, induces breast epithelial cell apoptosis through ERK/DRP-1 pathway.
Proteomic analysis reveals that Xbp1s promotes hypoxic pulmonary hypertension through the p-JNK MAPK pathway.
PP2A promotes apoptosis and facilitates docetaxel sensitivity via the PP2A/p-eIF4B/XIAP signaling pathway in prostate cancer.
Kruppel-like factor 2 acts as a tumor suppressor in human retinoblastoma.
Inhibition of IRE1 suppresses the catabolic effect of IL-1β on nucleus pulposus cell and prevents intervertebral disc degeneration in vivo.
Immune-responsive gene 1 protects against liver injury caused by concanavalin A via the activation Nrf2/HO-1 pathway and inhibition of ROS activation pathways.
Expressions and significances of CTSL, the target of COVID-19 on GBM.
SiRNA-circFARSA-loaded porous silicon nanomaterials for pancreatic cancer treatment via inhibition of CircFARSA expression.
Shikonin induces apoptosis and autophagy via downregulation of pyrroline-5-carboxylate reductase1 in hepatocellular carcinoma cells.
Circular RNA triple functional domain promotes osteoarthritis' development by modulating the microRNA-136-5p/Nicotinamide phosphoribosyltransferase axis.
Effects of transforming growth factor beta-activated kinase 1 (TAK1) on apoptosis of HK-2 cells in the high glucose environment.
Circular RNA SET domain protein 3 promotes nasopharyngeal carcinoma proliferation, cisplatin resistance, and protein kinase B / mammalian target of rapamycin pathway activation by modulating microRNA-147a expression.
Design, synthesis and biological evaluation of marine phidianidine-inspired derivatives against oxidized ldl-induced endothelial injury by activating Nrf2 anti-oxidation pathway.
Complement C1q binding protein regulates T cells' mitochondrial fitness to affect their survival, proliferation, and anti-tumor immune function.
Downregulation of NCL attenuates tumor formation and growth in HeLa cells by targeting the PI3K/AKT pathway.
Polysaccharides from Platycodonis Radix ameliorated respiratory syncytial virus-induced epithelial cell apoptosis and inflammation through activation of miR-181a-mediated Hippo and SIRT1 pathways.
Venetoclax enhances NK cell killing sensitivity of AML cells through the NKG2D/NKG2DL activation pathway.
Targeted Polymeric Nanoparticles Based on Mangiferin for Enhanced Protection of Pancreatic β-Cells and Type 1 Diabetes Mellitus Efficacy.
Tanshinone IIA regulates glycogen synthase kinase-3β-related signaling pathway and ameliorates memory impairment in APP/PS1 transgenic mice.
Blocking protease-activated receptor 4 alleviates liver injury induced by brain death.
Chlorine disinfection elevates the toxicity of polystyrene microplastics to human cells by inducing mitochondria-dependent apoptosis.
m(6)A mRNA modification maintains colonic epithelial cell homeostasis via NF-κB-mediated antiapoptotic pathway.
Curcumin ameliorates HO-induced injury through SIRT1-PERK-CHOP pathway in pancreatic beta cells.
Autophagy Promotes α-Amanitin-Induced Apoptosis of Hepa1-6 Liver Cells.
Dioscin relieves diabetic nephropathy via suppressing oxidative stress and apoptosis, and improving mitochondrial quality and quantity control.
Dihydrohomoplantagin and Homoplantaginin, Major Flavonoid Glycosides from Salvia plebeia R. Br. Inhibit oxLDL-Induced Endothelial Cell Injury and Restrict Atherosclerosis via Activating Nrf2 Anti-Oxidation Signal Pathway.
Chelerythrine inhibits the progression of glioblastoma by suppressing the TGFB1-ERK1/2/Smad2/3-Snail/ZEB1 signaling pathway.
Pan-cancer analysis, cell and animal experiments revealing TEAD4 as a tumor promoter in ccRCC.
Protective Effects of Taraxasterol against Deoxynivalenol-Induced Damage to Bovine Mammary Epithelial Cells.
Inhibition of STAT3(Y705) phosphorylation by Stattic suppresses proliferation and induces mitochondrial-dependent apoptosis in pancreatic cancer cells.
The Novel Competing Endogenous Long Noncoding RNA SM2 Regulates Gonadotropin Secretion in the Hu Sheep Anterior Pituitary by Targeting the Oar-miR-16b/TGF-β/SMAD2 Signaling Pathway.
Knockdown of long noncoding RNA MIAT attenuates cigarette smoke-induced airway remodeling by downregulating miR-29c-3p-HIF3A axis.
Oxidative stress activates Ryr2-Ca(2+) and apoptosis to promote PM(2.5)-induced heart injury of hyperlipidemia mice.
Low energy shock wave therapy attenuates mitochondrial dysfunction and improves bladder function in HCl induced cystitis in rats.
Protection of CAPE-pNO(2) Against Chronic Myocardial Ischemia by the TGF-Β1/Galectin-3 Pathway In Vivo and In Vitro.
LncRNA small nucleolar RNA host gene 16 reduces sepsis-induced myocardial damage by regulating miR-421/suppressor of cytokine signaling 5 axis.
Naringin alleviates acetaminophen-induced acute liver injury by activating Nrf2 via CHAC2 upregulation.
microRNA-486-5p is implicated in the cisplatin-induced apoptosis and acute inflammation response of renal tubular epithelial cells by targeting HAT1.
In situ forming and biocompatible hyaluronic acid hydrogel with reactive oxygen species-scavenging activity to improve traumatic brain injury repair by suppressing oxidative stress and neuroinflammation.
Effect of miR-101 on the Proliferation and Apoptosis of Goat Hair Follicle Stem Cells.
Carboxymethyl Chitosan Modified Oxymatrine Liposomes for the Alleviation of Emphysema in Mice via Pulmonary Administration.
CircEZH2/miR-133b/IGF2BP2 aggravates colorectal cancer progression via enhancing the stability of m(6)A-modified CREB1 mRNA.
Design, Synthesis, and Biological Evaluation of N14-Amino Acid-Substituted Tetrandrine Derivatives as Potential Antitumor Agents against Human Colorectal Cancer.
Pharmacological Inhibition of Endogenous Hydrogen Sulfide Attenuates Breast Cancer Progression.
A novel phosphodiesterase 9A inhibitor LW33 protects against ischemic stroke through the cGMP/PKG/CREB pathway.
Comparative and mechanistic study of pharmacodynamic difference in anti-breast cancer activity between water and liquor extracts of Xiaojin Pills.
Platelet-Membrane-Encapsulated Carvedilol with Improved Targeting Ability for Relieving Myocardial Ischemia-Reperfusion Injury.
METTL3 mediates osteoblast apoptosis by regulating endoplasmic reticulum stress during LPS-induced inflammation.
Loss of cell division cycle‑associated 5 promotes cell apoptosis by activating DNA damage response in clear cell renal cell carcinoma.
Dopamine 1 receptors inhibit apoptosis via activating CSE/H(2) S pathway in high glucose-induced vascular endothelial cells.
Inhibition of PDK1 enhances radiosensitivity and reverses epithelial-mesenchymal transition in nasopharyngeal carcinoma.
Melatonin improves bisphenol A-induced cell apoptosis, oxidative stress and autophagy impairment via inhibition of the p38 MAPK signaling pathway in FLK-BLV cells.
MicroRNA profiling reveals miR-145-5p inhibits goat myoblast differentiation by targeting the coding domain sequence of USP13.
The mitochondrial protein Sideroflexin 3 (SFXN3) influences neurodegeneration pathways in vivo.
SERPINA1 is a hub gene associated with intervertebral disc degeneration grade and affects the nucleus pulposus cell phenotype through the ADIRF-AS1/miR-214-3p axis.
Insulin and liraglutide attenuate brain pathology in diabetic mice by enhancing the Wnt/β-catenin signaling pathway.
Berberine exerts protective effects on cardiac senescence by regulating the Klotho/SIRT1 signaling pathway.
Effect of alfalfa substituted with ramie on the expression of apoptotic genes in the gastrointestinal tracts of goats.
Box C/D snoRNA SNORD89 influences the occurrence and development of endometrial cancer through 2'-O-methylation modification of Bim.
Akkermansia muciniphila Colonization Alleviating High Fructose and Restraint Stress-Induced Jejunal Mucosal Barrier Disruption.
T-2 Toxin Induces Apoptotic Cell Death and Protective Autophagy in Mouse Microglia BV2 Cells.
Revealing the mechanism of Jiegeng decoction attenuates bleomycin-induced pulmonary fibrosis via PI3K/Akt signaling pathway based on lipidomics and transcriptomics.
SIRT4 functions as a tumor suppressor during prostate cancer by inducing apoptosis and inhibiting glutamine metabolism.
A small-molecule Skp1 inhibitor elicits cell death by p53-dependent mechanism.
RBM47 inhibits hepatocellular carcinoma progression by targeting UPF1 as a DNA/RNA regulator.
Effects of bamboo leaf extract intervention on the growth performance, antioxidant capacity, and hepatic apoptosis in suckling piglets.
Study on the new anti-atherosclerosis activity of different Herba patriniae through down-regulating lysophosphatidylcholine of the glycerophospholipid metabolism pathway.
Expression pattern of alkB homolog 5 in goat testis and its role in spermatogonial stem cells.
PKM2 compensates for proteasome dysfunction by mediating the formation of the CHIP-HSP70-BAG3 complex and the aggregation of ubiquitinated proteins.
Circular RNA circUSP13 sponges miR-29c to promote differentiation and inhibit apoptosis of goat myoblasts by targeting IGF1.
TRIM59 promotes osteosarcoma progression via activation of STAT3.
Carrier-Free Delivery of Ultrasmall π-Conjugated Oligomer Nanoparticles with Photothermal Conversion over 80% for Cancer Theranostics.
Ki20227 aggravates apoptosis, inflammatory response, and oxidative stress after focal cerebral ischemia injury.
Jujuboside A ameliorates high fat diet and streptozotocin induced diabetic nephropathy via suppressing oxidative stress, apoptosis, and enhancing autophagy.
Targeting the Pro-survival Protein BCL-2 to Prevent Breast Cancer.
Knockdown of forkhead box protein P1 alleviates hypoxia reoxygenation injury in H9c2 cells through regulating Pik3ip1/Akt/eNOS and ROS/mPTP pathway.
Injectable hyaluronic acid hydrogel loaded with BMSC and NGF for traumatic brain injury treatment.
Inhibition of CDK1 attenuates neuronal apoptosis and autophagy and confers neuroprotection after chronic spinal cord injury in vivo.
Inhibition of the proliferation, invasion, migration, and epithelial-mesenchymal transition of prostate cancer cells through the action of ATP1A2 on the TGF-β/Smad pathway.
Cotargeting of Bcl-2 and Mcl-1 shows promising antileukemic activity against AML cells including those with acquired cytarabine resistance.
Deglycosylated EpCAM regulates proliferation by enhancing autophagy of breast cancer cells via PI3K/Akt/mTOR pathway.
Involvement of caspase in patulin-induced hepatotoxicity in vitro and in vivo.
The bibenzyl derivatives of Dendrobium officinale prevent UV-B irradiation induced photoaging via SIRT3.
Betulinic acid self-assembled nanoparticles for effective treatment of glioblastoma.
4,5-Dimethoxycanthin-6-one is a novel LSD1 inhibitor that inhibits proliferation of glioblastoma cells and induces apoptosis and pyroptosis.
Salidroside alleviates oxidative stress and apoptosis via AMPK/Nrf2 pathway in DHT-induced human granulosa cell line KGN.
Inhibition of Rac1 attenuates radiation-induced lung injury while suppresses lung tumor in mice.
Short-term starvation synergistically enhances cytotoxicity of Niraparib via Akt/mTOR signaling pathway in ovarian cancer therapy.
Anti-tumor effect of Yanggan Huayu granule by inducing AKT-mediated apoptosis in hepatocellular carcinoma.
ATF4/CEMIP/PKCα promotes anoikis resistance by enhancing protective autophagy in prostate cancer cells.
Lactobacillus rhamnosus Ameliorates Multi-Drug-Resistant Bacillus cereus-Induced Cell Damage through Inhibition of NLRP3 Inflammasomes and Apoptosis in Bovine Endometritis.
Downregulation of HSPA12A underlies myotoxicity of local anesthetic agent bupivacaine through inhibiting PGC1α-mediated mitochondrial integrity.
Pre-ischemic exercise prevents inflammation and apoptosis by inhibiting MAPK pathway in ischemic stroke.
Integrating network pharmacology deciphers the action mechanism of Zuojin capsule in suppressing colorectal cancer.
Lysophosphatidylcholine disrupts cell adhesion and induces anoikis in hepatocytes.
Inhibition of gap junction communication between cells can induce apoptosis of corpus cavernosum smooth muscle in guinea pigs.
Inhibition of the miR-193b-3p protects against oxidized low-density lipoprotein-induced HUVECs injury by upregulating ALDH2.
MiR-4521 plays a tumor repressive role in growth and metastasis of hepatocarcinoma cells by suppressing phosphorylation of FAK/AKT pathway via targeting FAM129A.
SKI knockdown suppresses apoptosis and extracellular matrix degradation of nucleus pulposus cells via inhibition of the Wnt/β-catenin pathway and ameliorates disc degeneration.
Extracellular vesicles of Lacticaseibacillus paracasei PC-H1 induce colorectal cancer cells apoptosis via PDK1/AKT/Bcl-2 signaling pathway.
Combination of the 6-thioguanine and disulfiram/Cu synergistically inhibits proliferation of triple-negative breast cancer cells by enhancing DNA damage and disrupting DNA damage checkpoint.
Inhibition of microRNA-29b suppresses oxidative stress and reduces apoptosis in ischemic stroke.
Genistein alleviates renin-angiotensin system mediated vascular and kidney alterations in renovascular hypertensive rats.
Polygonum cuspidatum inhibits the growth of osteosarcoma cells via impeding Akt/ERK/EGFR signaling pathways.
Knockdown of long non-coding RNA plasmacytoma variant translocation 1 relieves ox-LDL-induced endothelial cell injury through regulating microRNA-30c-5p in atherosclerosis.
Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy.
Integrative investigation of the TF-miRNA coregulatory network involved in the inhibition of breast cancer cell proliferation by resveratrol.
MiR-187 regulates the proliferation, migration and invasion of human trophoblast cells by repressing BCL6-mediated activation of PI3K/AKT signaling.
Berberine ameliorates erectile dysfunction in rats with streptozotocin-induced diabetes mellitus through the attenuation of apoptosis by inhibiting the SPHK1/S1P/S1PR2 and MAPK pathways.
Long non-coding RNA MALAT1 modulates myocardial ischemia-reperfusion injury through the PI3K/Akt/eNOS pathway by sponging miRNA-133a-3p to target IGF1R expression.
Design and synthesis of marine sesterterpene analogues as novel estrogen receptor α degraders for breast cancer treatment.
miR-196a Upregulation Contributes to Gefitinib Resistance through Inhibiting GLTP Expression.
Targeting and neutralizing human epididymis protein 4 by novel nanobodies to suppress ovarian cancer cells and attenuate cisplatin resistance.
Inhibition of Ceramide Glycosylation Enhances Cisplatin Sensitivity in Cholangiocarcinoma by Limiting the Activation of the ERK Signaling Pathway.
Hepatic Ischemia-reperfusion Injury in Mice was Alleviated by Rac1 Inhibition - More Than Just ROS-inhibition.
FTO protects human granulosa cells from chemotherapy-induced cytotoxicity.
Perfluorooctanoic acid induces hepatocellular endoplasmic reticulum stress and mitochondrial-mediated apoptosis in vitro via endoplasmic reticulum-mitochondria communication.
Isovitexin protects against acute liver injury by targeting PTEN, PI3K and BiP via modification of m6A.
RRM2 Alleviates Doxorubicin-Induced Cardiotoxicity through the AKT/mTOR Signaling Pathway.
A Second Near-Infrared Ru(II) Polypyridyl Complex for Synergistic Chemo-Photothermal Therapy.
Design, synthesis and biological evaluation of novel 1,3,4,9-tetrahydropyrano[3,4-b]indoles as potential treatment of triple negative breast cancer by suppressing PI3K/AKT/mTOR pathway.
Genistein interferes with antitumor effects of cisplatin in an ovariectomized breast cancer xenograft tumor model.
Berberine inhibits gastric cancer development and progression by regulating the JAK2/STAT3 pathway and downregulating IL-6.
Trimethylamine N-oxide promotes hyperoxaluria-induced calcium oxalate deposition and kidney injury by activating autophagy.
QiShenYiQi pill for myocardial collagen metabolism and apoptosis in rats of autoimmune cardiomyopathy.
Cinobufagin induces acute promyelocytic leukaemia cell apoptosis and PML-RARA degradation in a caspase-dependent manner by inhibiting the β-catenin signalling pathway.
Polyphyllin II induced apoptosis of NSCLC cells by inhibiting autophagy through the mTOR pathway.
Study on the biological mechanism of urolithin a on nasopharyngeal carcinoma in vitro.
A metabolomic approach to study triptolide-induced ovarian damage in rats.
Resveratrol inhibits the progression of premature senescence partially by regulating v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA) and sirtuin 1 (SIRT1).
Cystathionine γ-lyase mediates cell proliferation, migration, and invasion of nasopharyngeal carcinoma.
Involvement of the gut-brain axis in vascular depression via tryptophan metabolism: A benefit of short chain fatty acids.
c-Myc plays a critical role in the antileukemic activity of the Mcl-1-selective inhibitor AZD5991 in acute myeloid leukemia.
Mild hypothermia ameliorates hepatic ischemia reperfusion injury by inducing RBM3 expression.
Alfalfa saponins inhibit oxidative stress-induced cell apoptosis through the MAPK signaling pathway.
Acteoside alleviates dextran sulphate sodium‑induced ulcerative colitis via regulation of the HO‑1/HMGB1 signaling pathway.
FBXL6 depletion restrains clear cell renal cell carcinoma progression.
Melatonin alleviates arginine vasopressin-induced cardiomyocyte apoptosis via increasing Mst1-Nrf2 pathway activity to reduce oxidative stress.
Tumor-targeted dual-starvation therapy based on redox-responsive micelle nanosystem with co-loaded LND and BPTES.
Stilbene B10 induces apoptosis and tumor suppression in lymphoid Raji cells by BTK-mediated regulation of the KRAS/HDAC1/EP300/PEBP1 axis.
The transcription factor KLF14 attenuates LPS-induced acute lung injury by ameliorating apoptosis of alveolar epithelial cells in mice.
Inhibition of cell proliferation by Tas of foamy viruses through cell cycle arrest or apoptosis underlines the different mechanisms of virus-host interactions.
Artemisitene suppresses rheumatoid arthritis progression via modulating METTL3-mediated N6-methyladenosine modification of ICAM2 mRNA in fibroblast-like synoviocytes.
Isolongifolene alleviates liver ischemia/reperfusion injury by regulating AMPK-PGC1α signaling pathway-mediated inflammation, apoptosis, and oxidative stress.
Effects of betaine on viability, apoptosis, function protein expression and oxidative status in heat-stressed IEC-6 cells.
Targeting CRL4 suppresses chemoresistant ovarian cancer growth by inducing mitophagy.
Circ-CREBBP inhibits sperm apoptosis via the PI3K-Akt signaling pathway by sponging miR-10384 and miR-143-3p.
Resveratrol inhibits proliferation and induces apoptosis via the Hippo/YAP pathway in human colon cancer cells.
Inhibitory effect of calycosin on breast cancer cell progression through downregulating lncRNA HOTAIR and downstream targets: HuR and IGF2BP1.
microRNA-338-3p suppresses lipopolysaccharide-induced inflammatory response in HK-2 cells.
Multi-specific niflumic acid platinum(IV) complexes displaying potent antitumor activities by improving immunity and suppressing angiogenesis besides causing DNA damage.
Platycodon grandiflorus Polysaccharides Alleviate Cr(VI)-Induced Apoptosis in DF-1 Cells via ROS-Drp1 Signal Pathway.
Inactivation of Yes-Associated Protein Mediates Trophoblast Dysfunction: A New Mechanism of Pregnancy Loss Associated with Anti-Phospholipid Antibodies?
Inhibition of TIGAR Increases Exogenous p53 and Cisplatin Combination Sensitivity in Lung Cancer Cells by Regulating Glycolytic Flux.
Thrombus Inhibition and Neuroprotection for Ischemic Stroke Treatment through Platelet Regulation and ROS Scavenging.
Anti-Tumor Effects of Engineered VNP20009-Abvec-Igκ-mPD-1 Strain in Melanoma Mice via Combining the Oncolytic Therapy and Immunotherapy.
FUT2 Facilitates Autophagy and Suppresses Apoptosis via p53 and JNK Signaling in Lung Adenocarcinoma Cells.
Adipose-Derived Mesenchymal Stem Cells Alleviate Hypertrophic Scar by Inhibiting Bioactivity and Inducing Apoptosis in Hypertrophic Scar Fibroblasts.
Macrophages regulate vascular smooth muscle cell function during atherosclerosis progression through IL-1β/STAT3 signaling.
Adiponectin/AdiopR1 signaling prevents mitochondrial dysfunction and oxidative injury after traumatic brain injury in a SIRT3 dependent manner.
Effect of low energy shock wave on testicular microenvironment homeostasis in rats.
Identification and verification of the role of crucial genes through which methionine restriction inhibits the progression of colon cancer cells.
Nav1.6 promotes the progression of human follicular thyroid carcinoma cells via JAK-STAT signaling pathway.
Protective Effects of Three Flavonoids from Dendrobium huoshanense Flowers on Alcohol-Induced Hepatocyte Injury via Activating Nrf2 and Inhibiting NF-κB Pathways.
The miR-410-5p /ITGA6 axis participates in the pathogenesis of recurrent abortion by regulating the biological function of trophoblast.
CD13 downregulation mediated by ubenimex inhibits autophagy to overcome 5-FU resistance by disturbing the EMP3/FAK/NF-κB pathway in gastric cancer cells.
Phosphorylated STYK1 restrains the inhibitory role of EGFR in autophagy initiation and EGFR-TKIs sensitivity.
The Relationship between Procyanidin Structure and Their Protective Effect in a Parkinson's Disease Model.
Design, synthesis, and in vitro protective effect evaluation of α-carboline derivatives against H(2)O(2)-induced cardiomyocyte injury.
Discovery of precision targeting EZH2 degraders for triple-negative breast cancer.
Hyaluronic Acid Oligosaccharide Derivatives Alleviate Lipopolysaccharide-Induced Inflammation in ATDC5 Cells by Multiple Mechanisms.
Inhibition of autophagy potentiates the cytotoxicity of the irreversible FGFR1-4 inhibitor FIIN-2 on lung adenocarcinoma.
Assembly of Celastrol to Zeolitic Imidazolate Framework-8 by Coordination as a Novel Drug Delivery Strategy for Cancer Therapy.
Non-Esterified Fatty Acid Induces ER Stress-Mediated Apoptosis via ROS/MAPK Signaling Pathway in Bovine Mammary Epithelial Cells.
The microRNA-10b-Bim axis promotes cancer progression through activating autophagy in oral squamous cell carcinoma.
Development of a series of flurbiprofen and zaltoprofen platinum(IV) complexes with anti-metastasis competence targeting COX-2, PD-L1 and DNA.
Regulation of the sensitivity of hepatocarcinoma cells by ORMDL3, to sorafenib by autophagy.
12/15-Lipoxygenase Regulation of Diabetic Cognitive Dysfunction Is Determined by Interfering with Inflammation and Cell Apoptosis.
Sparstolonin B inhibits pancreatic adenocarcinoma through the NF-κB signaling pathway.
Acetyl CoA synthase 2 potentiates ATG5-induced autophagy against neuronal apoptosis after subarachnoid hemorrhage.
Copper induces oxidative stress and apoptosis of hippocampal neuron via pCREB/BDNF/ and Nrf2/HO-1/NQO1 pathway.
MiR-125b enhances doxorubicin-induced cardiotoxicity by suppressing the nucleus-cytoplasmic translocation of YAP via targeting STARD13.
TIMP2 mediates endoplasmic reticulum stress contributing to sepsis-induced acute kidney injury.
Andrographolide Inhibits Proliferation and Promotes Apoptosis in Bladder Cancer Cells by Interfering with NF- κ B and PI3K/AKT Signaling In Vitro and In Vivo.
Pharmacological inhibition of CDK7 by THZ1 impairs tumor growth in p53-mutated HNSCC.
DEC1 promotes progression of Helicobacter pylori-positive gastric cancer by regulating Akt/NF-κB pathway.
Tetrastigma hemsleyanum Diels et Gilg ameliorates lipopolysaccharide induced sepsis via repairing the intestinal mucosal barrier.
Guizhi Fuling pill attenuates liver fibrosis in vitro and in vivo via inhibiting TGF-β1/Smad2/3 and activating IFN-γ/Smad7 signaling pathways.
TIM-1 promotes proliferation and metastasis, and inhibits apoptosis, in cervical cancer through the PI3K/AKT/p53 pathway.
Protective effects of 5(S)-5-carboxystrictosidine on myocardial ischemia-reperfusion injury through activation of mitochondrial KATP channels.
Targeting IL8 as a sequential therapy strategy to overcome chemotherapy resistance in advanced gastric cancer.
Preventive effects of the AMPA receptor potentiator LY450108 in an LPS-induced depressive mouse model.
Map of Enteropathogenic Escherichia coli Targets Mitochondria and Triggers DRP-1-Mediated Mitochondrial Fission and Cell Apoptosis in Bovine Mastitis.
Brusatol inhibits the growth of renal cell carcinoma by regulating the PTEN/PI3K/AKT pathway.
Oxidative Stress-Induced TRPV2 Expression Increase Is Involved in Diabetic Cataracts and Apoptosis of Lens Epithelial Cells in a High-Glucose Environment.
The microbiota-gut-brain axis participates in chronic cerebral hypoperfusion by disrupting the metabolism of short-chain fatty acids.
NaAsO(2) decreases GSH synthesis by inhibiting GCLC and induces apoptosis through Hela cell mitochondrial damage, mediating the activation of the NF-κB/miR-21 signaling pathway.
Chaperone-mediated autophagy plays an important role in regulating retinal progenitor cell homeostasis.
Comprehensive analysis of abnormal expression, prognostic value and oncogenic role of the hub gene FN1 in pancreatic ductal adenocarcinoma via bioinformatic analysis and in vitro experiments.
Identification of KIF4A as a pan-cancer diagnostic and prognostic biomarker via bioinformatics analysis and validation in osteosarcoma cell lines.
Inhibitory effect and mechanism of action (MOA) of hirsutine on the proliferation of T-cell leukemia Jurkat clone E6-1 cells.
The GDF11 Promotes Nerve Regeneration After Sciatic Nerve Injury in Adult Rats by Promoting Axon Growth and Inhibiting Neuronal Apoptosis.
Apigenin Alleviates Intervertebral Disc Degeneration via Restoring Autophagy Flux in Nucleus Pulposus Cells.
Hypoxia Activates Notch4 via ERK/JNK/P38 MAPK Signaling Pathways to Promote Lung Adenocarcinoma Progression and Metastasis.
LncRNA FEZF1-AS1 Promotes Multi-Drug Resistance of Gastric Cancer Cells via Upregulating ATG5.
Syndromic Deafness Gene ATP6V1B2 Controls Degeneration of Spiral Ganglion Neurons Through Modulating Proton Flux.
The Regulatory Role of GBF1 on Osteoclast Activation Through EIF2a Mediated ER Stress and Novel Marker FAM129A Induction.
Apatinib Suppresses Gastric Cancer Stem Cells Properties by Inhibiting the Sonic Hedgehog Pathway.
Ufbp1, a Key Player of Ufm1 Conjugation System, Protects Against Ketosis-Induced Liver Injury via Suppressing Smad3 Activation.
NLGN3 Upregulates Expression of ADAM10 to Promote the Cleavage of NLGN3 via Activating the LYN Pathway in Human Gliomas.
Rutaecarpine Inhibits Doxorubicin-Induced Oxidative Stress and Apoptosis by Activating AKT Signaling Pathway.
Auranofin and ICG-001 Emerge Synergistic Anti-tumor Effect on Canine Breast Cancer by Inducing Apoptosis via Mitochondrial Pathway.
Maslinic Acid Attenuates Ischemia/Reperfusion Injury-Induced Myocardial Inflammation and Apoptosis by Regulating HMGB1-TLR4 Axis.
Citric Acid Promoting B Lymphocyte Differentiation and Anti-epithelial Cells Apoptosis Mediate the Protective Effects of Hermetia illucens Feed in ETEC Induced Piglets Diarrhea.
The Role of TRPC6 in Renal Ischemia/Reperfusion and Cellular Hypoxia/Reoxygenation Injuries.
Traditional Chinese Medication Qiliqiangxin Attenuates Diabetic Cardiomyopathy via Activating PPARγ.
Plasma Purification Treatment Relieves the Damage of Hyperlipidemia to PBMCs.
Sinomenine Suppresses Development of Hepatocellular Carcinoma Cells via Inhibiting MARCH1 and AMPK/STAT3 Signaling Pathway.
Lactobacillus acidophilus ATCC 4356 Alleviates Renal Ischemia-Reperfusion Injury Through Antioxidant Stress and Anti-inflammatory Responses and Improves Intestinal Microbial Distribution.
Exosomal MicroRNA-181a Derived From Mesenchymal Stem Cells Improves Gut Microbiota Composition, Barrier Function, and Inflammatory Status in an Experimental Colitis Model.
Pilose Antler Peptide-3.2KD Ameliorates Adriamycin-Induced Myocardial Injury Through TGF-β/SMAD Signaling Pathway.
Hengshun Aromatic Vinegar Ameliorates Vascular Endothelial Injury via Regulating PKCζ-Mediated Oxidative Stress and Apoptosis.
Liraglutide Protects Nucleus Pulposus Cells Against High-Glucose Induced Apoptosis by Activating PI3K/Akt/ mTOR/Caspase-3 and PI3K/Akt/GSK3β/Caspase-3 Signaling Pathways.
Gentiopicroside Inhibits Cell Growth and Migration on Cervical Cancer via the Reciprocal MAPK/Akt Signaling Pathways.
Resveratrol Inhibition of Renal Cancer Stem Cell Characteristics and Modulation of the Sonic Hedgehog Pathway.
EphA2 overexpression reduces H2O2-induced damage of lens epithelial cells.
Shen-fu injection alleviates acute renal injury by reducing cytokine levels and modulating apoptosis in a porcine hemorrhagic shock model.
H2S improves doxorubicin-induced myocardial fibrosis by inhibiting oxidative stress and apoptosis via Keap1-Nrf2.
Lipidomic Alterations and PPARα Activation Induced by Resveratrol Lead to Reduction in Lesion Size in Endometriosis Models.
Long Noncoding RNA HCG9 Promotes Osteosarcoma Progression through RAD51 by Acting as a ceRNA of miR-34b-3p.
Huxie Huaji Ointment Induced Apoptosis of Liver Cancer Cells In Vivo and In Vitro by Activating the Mitochondrial Pathway.
Escin Sodium Improves the Prognosis of Acute Pancreatitis via Promoting Cell Apoptosis by Suppression of the ERK/STAT3 Signaling Pathway.
PICK1 Deficiency Exacerbates Sepsis-Associated Acute Kidney Injury.
Mechanosensitive Ion Channel Piezo1 Activated by Matrix Stiffness Regulates Oxidative Stress-Induced Senescence and Apoptosis in Human Intervertebral Disc Degeneration.
Melatonin Attenuates Diabetic Myocardial Microvascular Injury through Activating the AMPK/SIRT1 Signaling Pathway.
Tetrandrine Ameliorates Myocardial Ischemia Reperfusion Injury through miR-202-5p/TRPV2.
Sodium Houttuyfonate Ameliorates β-amyloid(1-42)-Induced Memory Impairment and Neuroinflammation through Inhibiting the NLRP3/GSDMD Pathway in Alzheimer's Disease.
Effects of Noninvasive Low-Intensity Focus Ultrasound Neuromodulation on Spinal Cord Neurocircuits In Vivo.
Catalpol-Induced AMPK Activation Alleviates Cisplatin-Induced Nephrotoxicity through the Mitochondrial-Dependent Pathway without Compromising Its Anticancer Properties.
Tilianin Ameliorates Cognitive Dysfunction and Neuronal Damage in Rats with Vascular Dementia via p-CaMKII/ERK/CREB and ox-CaMKII-Dependent MAPK/NF-κB Pathways.
Fenofibrate Ameliorates Hepatic Ischemia/Reperfusion Injury in Mice: Involvements of Apoptosis, Autophagy, and PPAR-α Activation.
Quercetin Alleviates Intervertebral Disc Degeneration by Modulating p38 MAPK-Mediated Autophagy.
Combined Treatment of Cinobufotalin and Gefitinib Exhibits Potent Efficacy against Lung Cancer.
Imbalance of Autophagy and Apoptosis Induced by Oxidative Stress May Be Involved in Thyroid Damage Caused by Sleep Deprivation in Rats.
Babao Dan Reverses Multiple-Drug Resistance in Gastric Cancer Cells via Triggering Apoptosis and Autophagy and Inhibiting PI3K/AKT/mTOR Signaling.
Programmed NP Cell Death Induced by Mitochondrial ROS in a One-Strike Loading Disc Degeneration Organ Culture Model.
Tubeimoside I Ameliorates Myocardial Ischemia-Reperfusion Injury through SIRT3-Dependent Regulation of Oxidative Stress and Apoptosis.
Study on the Antitumor Effect and Glycolysis of Andrographolide in Anaplastic Thyroid Carcinoma.
The Role of Exercise in Reducing Hyperlipidemia-Induced Neuronal Damage in Apolipoprotein E-Deficient Mice.
Exploration of the Danggui Buxue Decoction Mechanism Regulating the Balance of ESR and AR in the TP53-AKT Signaling Pathway in the Prevention and Treatment of POF.
The Dietary Supplement γ-Oryzanol Attenuates Hepatic Ischemia Reperfusion Injury via Inhibiting Endoplasmic Reticulum Stress and HMGB1/NLRP3 Inflammasome.
Effects of MicroRNA-195-5p on Biological Behaviors and Radiosensitivity of Lung Adenocarcinoma Cells via Targeting HOXA10.
Recombinant Human Growth Hormone Inhibits Lipotoxicity, Oxidative Stress, and Apoptosis in a Mouse Model of Diabetic Cardiomyopathy.
TSH Combined with TSHR Aggravates Diabetic Peripheral Neuropathy by Promoting Oxidative Stress and Apoptosis in Schwann Cells.
Trefoil Factor 3 Inhibits Thyroid Cancer Cell Progression Related to IL-6/JAK/STAT3 Signaling Pathway.
PKM2 Is a Potential Diagnostic and Therapeutic Target for Retinitis Pigmentosa.
miR-149 Suppresses the Proliferation and Metastasis of Human Gastric Cancer Cells by Targeting FOXC1.
USP37 downregulation elevates the Chemical Sensitivity of Human Breast Cancer Cells to Adriamycin.
Cyclovirobuxine inhibits the progression of clear cell renal cell carcinoma by suppressing the IGFBP3-AKT/STAT3/MAPK-Snail signalling pathway.
Discovery of a novel HDACi structure that inhibits the proliferation of ovarian cancer cells in vivo and in vitro.
CD44 modulates metabolic pathways and altered ROS-mediated Akt signal promoting cholangiocarcinoma progression.
Glucocorticoids protect HEI-OC1 cells from tunicamycin-induced cell damage via inhibiting endoplasmic reticulum stress.
Delivery of Rapamycin by Liposomes Synergistically Enhances the Chemotherapy Effect of 5-Fluorouracil on Colorectal Cancer.
Total Flavonoids of Chuju Decrease Oxidative Stress and Cell Apoptosis in Ischemic Stroke Rats: Network and Experimental Analyses.
Baicalin Alleviates Oxidative Stress and Inflammation in Diabetic Nephropathy via Nrf2 and MAPK Signaling Pathway.
Gypenosides Inhibit Inflammatory Response and Apoptosis of Endothelial and Epithelial Cells in LPS-Induced ALI: A Study Based on Bioinformatic Analysis and in vivo/vitro Experiments.
Effect of luteolin on apoptosis and vascular endothelial growth factor in human choroidal melanoma cells.
Engeletin Protects Against TNF-α-Induced Apoptosis and Reactive Oxygen Species Generation in Chondrocytes and Alleviates Osteoarthritis in vivo.
Hydrogen (H(2)) Alleviates Osteoarthritis by Inhibiting Apoptosis and Inflammation via the JNK Signaling Pathway.
lncRNA AC007207.2 Promotes Malignant Properties of Osteosarcoma via the miR-1306-5p/SIRT7 Axis.
MALAT-1 is Associated with the Doxorubicin Resistance in U-2OS Osteosarcoma Cells.
Analysis of m6A-Related lncRNAs for Prognosis Value and Response to Immune Checkpoint Inhibitors Therapy in Hepatocellular Carcinoma.
High-Fat Diet-Induced Mitochondrial Dysfunction Promotes Genioglossus Injury - A Potential Mechanism for Obstructive Sleep Apnea with Obesity.
SAA1 knockdown promotes the apoptosis of glioblastoma cells via downregulation of AKT signaling.
ARRB1 Drives Gallbladder Cancer Progression by Facilitating TAK1/MAPK Signaling Activation.
Keratin 80 regulated by miR-206/ETS1 promotes tumor progression via the MEK/ERK pathway in ovarian cancer.
Demethylzelasteral inhibits proliferation and EMT via repressing Wnt/β-catenin signaling in esophageal squamous cell carcinoma.
Myricanol Inhibits Platelet Derived Growth Factor-BB-Induced Vascular Smooth Muscle Cells Proliferation and Migration in vitro and Intimal Hyperplasia in vivo by Targeting the Platelet-Derived Growth Factor Receptor-β and NF-κB Signaling.
Baicalein Alleviates Osteoarthritis Progression in Mice by Protecting Subchondral Bone and Suppressing Chondrocyte Apoptosis Based on Network Pharmacology.
An Endogenous Retroviral LTR-Derived Long Noncoding RNA lnc-LTR5B Interacts With BiP to Modulate ALV-J Replication in Chicken Cells.
Exercise Capacity Is Improved by Levosimendan in Heart Failure and Sarcopenia via Alleviation of Apoptosis of Skeletal Muscle.
Qingda Granule Attenuates Angiotensin II-Induced Renal Apoptosis and Activation of the p53 Pathway.
Sempervirine Mediates Autophagy and Apoptosis via the Akt/mTOR Signaling Pathways in Glioma Cells.
Salmonella Infantis Delays the Death of Infected Epithelial Cells to Aggravate Bacterial Load by Intermittent Phosphorylation of Akt With SopB.
Transcriptomic Profiling Reveals the Antiapoptosis and Antioxidant Stress Effects of Fos in Ischemic Stroke.
The Abscopal Effects of Cranial Irradiation Induce Testicular Damage in Mice.
Ivermectin has New Application in Inhibiting Colorectal Cancer Cell Growth.
Lactobacillus rhamnosus GR-1 Prevents Escherichia coli-Induced Apoptosis Through PINK1/Parkin-Mediated Mitophagy in Bovine Mastitis.
Myricetin Induces Autophagy and Cell Cycle Arrest of HCC by Inhibiting MARCH1-Regulated Stat3 and p38 MAPK Signaling Pathways.
PBK/TOPK Inhibitor Suppresses the Progression of Prolactinomas.
miR-344-5p Modulates Cholesterol-Induced β-Cell Apoptosis and Dysfunction Through Regulating Caveolin-1 Expression.
Autophagy is Involved in Neuroprotective Effect of Alpha7 Nicotinic Acetylcholine Receptor on Ischemic Stroke.
Targeting Glycogen Synthase Kinase 3 Beta Regulates CD47 Expression After Myocardial Infarction in Rats via the NF-κB Signaling Pathway.
The New PI3K/mTOR Inhibitor GNE-477 Inhibits the Malignant Behavior of Human Glioblastoma Cells.
Aldehyde Dehydrogenase 2 Protects Against Lipopolysaccharide-Induced Myocardial Injury by Suppressing Mitophagy.
Oxytocin Attenuates Methamphetamine-Induced Apoptosis via Oxytocin Receptor in Rat Hippocampal Neurons.
Inhibition of BAG3 enhances the anticancer effect of shikonin in hepatocellular carcinoma.
The 14-3-3σ protein promotes HCC anoikis resistance by inhibiting EGFR degradation and thereby activating the EGFR-dependent ERK1/2 signaling pathway.
Relieving lipid accumulation through UCP1 suppresses the progression of acute kidney injury by promoting the AMPK/ULK1/autophagy pathway.
Hedgehog-Gli2 Signaling Promotes Chemoresistance in Ovarian Cancer Cells by Regulating MDR1.
Deferoxamine Counteracts Cisplatin Resistance in A549 Lung Adenocarcinoma Cells by Increasing Vulnerability to Glutamine Deprivation-Induced Cell Death.
Identification of CDCA2 as a Diagnostic and Prognostic Marker for Hepatocellular Carcinoma.
Periplocymarin Induced Colorectal Cancer Cells Apoptosis Via Impairing PI3K/AKT Pathway.
Ursolic Acid Inhibits Breast Cancer Metastasis by Suppressing Glycolytic Metabolism via Activating SP1/Caveolin-1 Signaling.
Targeting NUFIP1 Suppresses Growth and Induces Senescence of Colorectal Cancer Cells.
NUDT21 Promotes Tumor Growth and Metastasis Through Modulating SGPP2 in Human Gastric Cancer.
Pinocembrin Inhibits the Proliferation and Metastasis of Breast Cancer via Suppression of the PI3K/AKT Signaling Pathway.
The lncRNA ADAMTS9-AS2 Regulates RPL22 to Modulate TNBC Progression via Controlling the TGF-β Signaling Pathway.
N6-Methyladenosine Modification of LncRNA DUXAP9 Promotes Renal Cancer Cells Proliferation and Motility by Activating the PI3K/AKT Signaling Pathway.
MiR-454-3p Promotes Oxaliplatin Resistance by Targeting PTEN in Colorectal Cancer.
Epigallocatechin-3-gallate inhibits proliferation and triggers apoptosis in colon cancer via the hedgehog/phosphoinositide 3-kinase pathways.
TLR2 inhibition ameliorates the amplification effect of LPS on lipid accumulation and lipotoxicity in hepatic cells.
Homoharringtonine inhibits the progression of hepatocellular carcinoma by suppressing the PI3K/AKT/GSK3β/Slug signaling pathway.
Environmental Microcystin exposure in underlying NAFLD-induced exacerbation of neuroinflammation, blood-brain barrier dysfunction, and neurodegeneration are NLRP3 and S100B dependent.
Triclosan regulates the Nrf2/HO-1 pathway through the PI3K/Akt/JNK signaling cascade to induce oxidative damage in neurons.
Role of Notch pathway in effect of mono-2-ethylhexyl phthalate on the proliferation and cell cycle of SH-SY5Y cell.
Docosahexaenoic acid activates the Nrf2 signaling pathway to alleviate impairment of spleen cellular immunity in intrauterine growth restricted rat pups.
miR‑140‑5p alleviates mouse liver ischemia/reperfusion injury by targeting CAPN1.
Expression and purification of a recombinant ELRL-MAP30 with dual-targeting anti-tumor bioactivity.
Scutellarin ameliorates colitis-associated colorectal cancer by suppressing Wnt/β-catenin signaling cascade.
A self-amplified nanocatalytic system for achieving "1 + 1 + 1 > 3" chemodynamic therapy on triple negative breast cancer.
Fibroblast growth factor 21 (FGF21) alleviates senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the SIRT1-mTOR signaling pathway.
Xenon Nanobubbles for the Image-Guided Preemptive Treatment of Acute Ischemic Stroke via Neuroprotection and Microcirculatory Restoration.
Orexin-A Regulates Follicular Growth, Proliferation, Cell Cycle and Apoptosis in Mouse Primary Granulosa Cells via the AKT/ERK Signaling Pathway.
Chitosan-based nanoparticle co-delivery of docetaxel and curcumin ameliorates anti-tumor chemoimmunotherapy in lung cancer.
Scoparone inhibits pancreatic cancer through PI3K/Akt signaling pathway.
Tetrahydropalmatine Regulates BDNF through TrkB/CAM Interaction to Alleviate the Neurotoxicity Induced by Methamphetamine.
Effect of different exercise training intensities on age-related cardiac damage in male mice.
Bortezomib enhances the anti-cancer effect of the novel Bruton's tyrosine kinase inhibitor (BGB-3111) in mantle cell lymphoma expressing BTK.
IL-22 ameliorated cardiomyocyte apoptosis in cardiac ischemia/reperfusion injury by blocking mitochondrial membrane potential decrease, inhibiting ROS and cytochrome C.
miR-132-3p promotes the cisplatin-induced apoptosis and inflammatory response of renal tubular epithelial cells by targeting SIRT1 via the NF-κB pathway.
Enhancement of gemcitabine efficacy by K73-03 via epigenetically regulation of miR-421/SPINK1 in gemcitabine resistant pancreatic cancer cells.
Metformin alleviates bevacizumab-induced vascular endothelial injury by up-regulating GDF15 and activating the PI3K/AKT/FOXO/PPARγ signaling pathway.
Alpha-ketoglutarate ameliorates pressure overload-induced chronic cardiac dysfunction in mice.
Arctigenin inhibits cholangiocarcinoma progression by regulating cell migration and cell viability via the N-cadherin and apoptosis pathway.
Inhibition of ER stress attenuates kidney injury and apoptosis induced by 3-MCPD via regulating mitochondrial fission/fusion and Ca(2+) homeostasis.
Exosomes derived from idiopathic gingival fibroma fibroblasts regulate gingival fibroblast proliferation and apoptosis.
Adiponectin regulates osteocytic MLO-Y4 cell apoptosis in a high-glucose environment through the AMPK/FoxO3a signaling pathway.
ST8SIA1 inhibits the proliferation, migration and invasion of bladder cancer cells by blocking the JAK/STAT signaling pathway.
Overexpression of E74-like transformation-specific transcription factor 3 promotes cellular proliferation and predicts poor prognosis in ovarian cancer.
Hsa_circ_0004058 inhibits apoptosis of SRA01/04 cells by promoting autophagy via miR-186/ATG7 axis.
RSL3 enhances the antitumor effect of cisplatin on prostate cancer cells via causing glycolysis dysfunction.
LncRNA-Malat1 down-regulates miR-211-5p expression to promote neuronal damage from cerebral ischemia reperfusion injury.
Panax notoginseng saponins reduces the cisplatin-induced acute renal injury by increasing HIF-1α/BNIP3 to inhibit mitochondrial apoptosis pathway.
Silent information regulator 2 promotes clear cell renal cell carcinoma progression through deacetylation and small ubiquitin-related modifier 1 modification of glucose 6-phosphate dehydrogenase.
Long-term repetitive exposure to excess iodine induces mitochondrial apoptosis, and alters monoamine neurotransmitters in hippocampus of rats of different genders.
sTNFRII-Fc modification protects human UC-MSCs against apoptosis/autophagy induced by TNF-α and enhances their efficacy in alleviating inflammatory arthritis.
ECHS1, an interacting protein of LASP1, induces sphingolipid-metabolism imbalance to promote colorectal cancer progression by regulating ceramide glycosylation.
Diosgenin exerts anti-tumor effects through inactivation of cAMP/PKA/CREB signaling pathway in colorectal cancer.
Anti-Cancer Properties of Ginkgolic Acids in Human Nasopharyngeal Carcinoma CNE-2Z Cells via Inhibition of Heat Shock Protein 90.
The biological effect of cobalt chloride mimetic-hypoxia on nucleus pulposus cells and the comparability with physical hypoxia in vitro.
Activation of G protein coupled estrogen receptor prevents chemotherapy-induced intestinal mucositis by inhibiting the DNA damage in crypt cell in an extracellular signal-regulated kinase 1- and 2- dependent manner.
Disruption of Gprasp2 down-regulates Hedgehog signaling and leads to apoptosis in auditory cells.
MiR-10b-5p inhibits tumorigenesis in gastric cancer xenograft mice model through down-regulating Tiam1.
Co-modification with MSC membrane and PDA prevents Fe(3)O(4)-induced pulmonary toxicity in mice via AMPK-ULK1 axis.
Design, synthesis, and biological evaluation of 2,4-diamino pyrimidine derivatives as potent FAK inhibitors with anti-cancer and anti-angiogenesis activities.
SMAD2 regulates testicular development and testosterone synthesis in Hu sheep.
Methamphetamine mediates apoptosis of vascular smooth muscle cells via the chop-related endoplasmic reticulum stress pathway.
GRIM-19 inhibits proliferation and induces apoptosis in a p53-dependent manner in colorectal cancer cells through the SIRT7/PCAF/MDM2 axis.
Harpagide alleviate neuronal apoptosis and blood-brain barrier leakage by inhibiting TLR4/MyD88/NF-κB signaling pathway in Angiotensin II-induced microglial activation in vitro.
A-24, a steroidal saponin from Allium chinense, induced apoptosis, autophagy and migration inhibition in p53 wild-type and p53-deficient gastric cancer cells.
MiR-223-3p targets FOXO3a to inhibit radiosensitivity in prostate cancer by activating glycolysis.
Arsenic trioxide induces expression of BCL-2 expression via NF-κB and p38 MAPK signaling pathways in BEAS-2B cells during apoptosis.
Antagonizing effects of curcumin against mercury-induced autophagic death and trace elements disorder by regulating PI3K/AKT and Nrf2 pathway in the spleen.
Comparison of biological and transcriptomic effects of conventional cigarette and electronic cigarette smoke exposure at toxicological dose in BEAS-2B cells.
Patient-Derived Organoids Can Guide Personalized-Therapies for Patients with Advanced Breast Cancer.
Abnormally elevated ubiquilin‑1 expression in breast cancer regulates metastasis and stemness via AKT signaling.
Sanguinarine impairs lysosomal function and induces ROS-dependent mitophagy and apoptosis in human hepatocellular carcinoma cells.
Low-dose exposure to black carbon significantly increase lung injury of cadmium by promoting cellular apoptosis.
Effect of long-term exposure to acrylamide on endoplasmic reticulum stress and autophagy in rat cerebellum.
Anthocyanin from purple sweet potato attenuates lead-induced reproductive toxicity mediated by JNK signaling pathway in male mice.
EGFR and ERK activation resists flavonoid quercetin-induced anticancer activities in human cervical cancer cells in vitro.
Anticancer roles of let-7f-1-3p in non-small cell lung cancer via direct targeting of integrin β1.
miR-378d is Involved in the Regulation of Apoptosis and Autophagy of and E(2) Secretion from Cultured Ovarian Granular Cells Treated by Sodium Fluoride.
The anti-neoplastic activities of aloperine in HeLa cervical cancer cells are associated with inhibition of the IL-6-JAK1-STAT3 feedback loop.
INHBA transfection regulates proliferation, apoptosis and hormone synthesis in sheep granulosa cells.
Sesamin promotes apoptosis and pyroptosis via autophagy to enhance antitumour effects on murine T-cell lymphoma.
The inhibitory effect Polygonum Cillinerve polysaccharide on transmissible gastroenteritis virus of swine.
DOC-2/DAB2 interactive protein destabilizes c-Myc to impair the growth and self-renewal of colon tumor-repopulating cells.
Betaine alleviates right ventricular failure via regulation of Rho A/ROCK signaling pathway in rats with pulmonary arterial hypertension.
Taxifolin retards the D-galactose-induced aging process through inhibiting Nrf2-mediated oxidative stress and regulating the gut microbiota in mice.
Tβ4 ameliorates oxidative damage and apoptosis through ERK/MAPK and 5-HT1A signaling pathway in Aβ insulted SH-SY5Y cells.
Maternal selenium deficiency suppresses proliferation, induces autophagy dysfunction and apoptosis in the placenta of mice.
3-Epipachysamine B suppresses proliferation and induces apoptosis of breast cancer cell via PI3K/AKT/mTOR signaling pathway.
Changes in histology, protein expression, and autophagy in dairy goat testes during nonbreeding season†.
CDKN2B antisense RNA 1 suppresses tumor growth in human colorectal cancer by targeting MAPK inactivator dual-specificity phosphatase 1.
Melatonin enhances SIRT1 to ameliorate mitochondrial membrane damage by activating PDK1/Akt in granulosa cells of PCOS.
TGIF1 plays a carcinogenic role in esophageal squamous cell carcinoma through the Wnt/β‑catenin and Akt/mTOR signaling pathways.
Mzb1 protects against myocardial infarction injury in mice via modulating mitochondrial function and alleviating inflammation.
TUFM is involved in Alzheimer's disease-like pathologies that are associated with ROS.
Chlorogenic acid enhances autophagy by upregulating lysosomal function to protect against SH-SY5Y cell injury induced by H(2)O(2).
Expression and prognostic value of E2F3 transcription factor in non-small cell lung cancer.
Effects of SPATA6 on proliferation, apoptosis and steroidogenesis of Hu sheep Leydig cells in vitro.
Mitochondrial TXN2 attenuates amyloidogenesis via selective inhibition of BACE1 expression.
The Kidney-Related Effects of Polystyrene Microplastics on Human Kidney Proximal Tubular Epithelial Cells HK-2 and Male C57BL/6 Mice.
SEC61G promotes breast cancer development and metastasis via modulating glycolysis and is transcriptionally regulated by E2F1.
Verapamil inhibits early acute liver failure through suppressing the NLRP3 inflammasome pathway.
Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics.
Interleukin-17 aggravates right ventricular remodeling via activating STAT3 under both normoxia and hypoxia.
[Development and functional validation of a nano-delivery system of miR-16/polypeptide targeting ovarian cancer cells].
LncRNA CD27-AS1 promotes acute myeloid leukemia progression through the miR-224-5p/PBX3 signaling circuit.
Protective effect of recombinant Lactobacillus plantarum against H(2)O(2)-induced oxidative stress in HUVEC cells.
Loss of Camk2n1 aggravates cardiac remodeling and malignant ventricular arrhythmia after myocardial infarction in mice via NLRP3 inflammasome activation.
The HDAC and PI3K dual inhibitor CUDC-907 synergistically enhances the antileukemic activity of venetoclax in preclinical models of acute myeloid leukemia.
Valproic acid mitigates spinal nerve ligation-induced neuropathic pain in rats by modulating microglial function and inhibiting neuroinflammatory response.
Decreased miR-214-3p activates NF-κB pathway and aggravates osteoarthritis progression.
Chlorogenic acid inhibits proliferation in human hepatoma cells by suppressing noncanonical NF-κB signaling pathway and triggering mitochondrial apoptosis.
Inhibition of chondrocyte apoptosis in a rat model of osteoarthritis by exosomes derived from miR‑140‑5p‑overexpressing human dental pulp stem cells.
Cordyceps acid alleviates lung cancer in nude mice.
Apoptosis inhibition is involved in improvement of sevoflurane-induced cognitive impairment following normobaric hyperoxia preconditioning in aged rats.
Nuciferine protects against folic acid-induced acute kidney injury by inhibiting ferroptosis.
Three phytosterols from sweet potato inhibit MCF7-xenograft-tumor growth through modulating gut microbiota homeostasis and SCFAs secretion.
Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway.
miR-98-5p protects against cerebral ischemia/reperfusion injury through anti-apoptosis and anti-oxidative stress in mice.
PGC1α Promotes Cisplatin Resistance in Ovarian Cancer by Regulating the HSP70/HK2/VDAC1 Signaling Pathway.
CircRNA RSF1 regulated ox-LDL induced vascular endothelial cells proliferation, apoptosis and inflammation through modulating miR-135b-5p/HDAC1 axis in atherosclerosis.
Inhibition of lipogenesis and induction of apoptosis by valproic acid in prostate cancer cells via the C/EBPα/SREBP-1 pathway.
MiR-133a-3p relieves the oxidative stress induced trophoblast cell apoptosis through the BACH1/Nrf2/HO-1 signaling pathway.
The role of Se content in improving anti-tumor activities and its potential mechanism for selenized Artemisia sphaerocephala polysaccharides.
α-Solanine Inhibits Proliferation, Invasion, and Migration, and Induces Apoptosis in Human Choriocarcinoma JEG-3 Cells In Vitro and In Vivo.
Sesamin induces cell cycle arrest and apoptosis through p38/C-Jun N-terminal kinase mitogen-activated protein kinase pathways in human colorectal cancer cells.
Identifying miRNAs in multiple sclerosis gray matter lesions that correlate with atrophy measures.
WISP-1 induced by mechanical stress contributes to fibrosis and hypertrophy of the ligamentum flavum through Hedgehog-Gli1 signaling.
Drug-repositioning screening identified fludarabine and risedronic acid as potential therapeutic compounds for malignant pleural mesothelioma.
Temperature Variability Does Not Attenuate the Beneficial Effects of Therapeutic Hypothermia on Cellular Apoptosis and Endoplasmic Reticulum Stress in the Cerebral Cortex of a Swine Cardiac Arrest Model.
PIWIL2 interacting with IKK to regulate autophagy and apoptosis in esophageal squamous cell carcinoma.
Wogonin alleviates liver injury in sepsis through Nrf2-mediated NF-κB signalling suppression.
Ketoplatin in triple-negative breast cancer cells MDA-MB-231: High efficacy and low toxicity, and positive impact on inflammatory microenvironment.
Mir-34c affects the proliferation and pluripotency of porcine induced pluripotent stem cell (piPSC)-like cells by targeting c-Myc.
AMD3465 (hexahydrobromide) rescues the MG63 osteoblasts against the apoptosis induced by high glucose.
Effect of SOCS3 on apoptosis of human trophoblasts via adjustment of the JAK2/STAT3 signaling pathway in preterm birth.
YWHAE as an HE4 interacting protein can influence the malignant behaviour of ovarian cancer by regulating the PI3K/AKT and MAPK pathways.
Cellular FADD-like IL-1β-converting enzyme-inhibitory protein attenuates myocardial ischemia/reperfusion injury via suppressing apoptosis and autophagy simultaneously.
The combination of CUDC-907 and gilteritinib shows promising in vitro and in vivo antileukemic activity against FLT3-ITD AML.
Effects of β-Asarone on Ischemic Stroke in Middle Cerebral Artery Occlusion Rats by an Nrf2-Antioxidant Response Elements (ARE) Pathway-Dependent Mechanism.
Hypoxia induces chemoresistance of esophageal cancer cells to cisplatin through regulating the lncRNA-EMS/miR-758-3p/WTAP axis.
Anti-tumor effects of Solanum nigrum L. extraction on C6 high-grade glioma.
Long noncoding RNA LINC00284 facilitates cell proliferation in papillary thyroid cancer via impairing miR-3127-5p targeted E2F7 suppression.
DNA methylation mediated RSPO2 to promote follicular development in mammals.
DUSP1 overexpression attenuates renal tubular mitochondrial dysfunction by restoring Parkin-mediated mitophagy in diabetic nephropathy.
VHL regulates the sensitivity of clear cell renal cell carcinoma to SIRT4-mediated metabolic stress via HIF-1α/HO-1 pathway.
NPRL2 reduces the niraparib sensitivity of castration-resistant prostate cancer via interacting with UBE2M and enhancing neddylation.
Bone marrow-derived mesenchymal stem cells attenuate silica-induced pulmonary fibrosis by inhibiting apoptosis and pyroptosis but not autophagy in rats.
Helenalin Facilitates Reactive Oxygen Species-Mediated Apoptosis and Cell Cycle Arrest by Targeting Thioredoxin Reductase-1 in Human Prostate Cancer Cells.
The Long-Term DEHP Exposure Confers Multidrug Resistance of Triple-Negative Breast Cancer Cells through ABC Transporters and Intracellular ROS.
A neutral polysaccharide from Ophiocordyceps lanpingensis restrains cisplatin-induced nephrotoxicity.
Electroacupuncture at GV20‑GB7 regulates mitophagy to protect against neurological deficits following intracerebral hemorrhage via inhibition of apoptosis.
2-Methoxyestradiol synergizes with Erlotinib to suppress hepatocellular carcinoma by disrupting the PLAGL2-EGFR-HIF-1/2α signaling loop.
LncRNA TONSL-AS1 participates in coronary artery disease by interacting with miR-197.
Choline attenuates heat stress-induced oxidative injury and apoptosis in bovine mammary epithelial cells by modulating PERK/Nrf-2 signaling pathway.
Amyloid-β (25-35) regulates neuronal damage and memory loss via SIRT1/Nrf2 in the cortex of mice.
Anti-CD19 mAb modified mesoporous titanium dioxide as exclusively targeting vector for efficient B-lymphoblastic leukemia therapy.
Tubeimoside I improves endothelial function in sepsis via activation of SIRT3.
Andrographolide Attenuates Gut-Brain-Axis Associated Pathology in Gulf War Illness by Modulating Bacteriome-Virome Associated Inflammation and Microglia-Neuron Proinflammatory Crosstalk.
Prognostic signature composed of transcription factors accurately predicts the prognosis of gastric cancer patients.
Glycoursodeoxycholic acid ameliorates diet-induced metabolic disorders with inhibiting endoplasmic reticulum stress.
miR-126 Controls the Apoptosis and Proliferation of Immature Porcine Sertoli Cells by Targeting the PIK3R2 Gene through the PI3K/AKT Signaling Pathway.
A novel chemical inhibitor suppresses breast cancer cell growth and metastasis through inhibiting HPIP oncoprotein.
NUDCD1 knockdown inhibits the proliferation, migration, and invasion of pancreatic cancer via the EMT process.
The anti-dysenteric drug fraxetin enhances anti-tumor efficacy of gemcitabine and suppresses pancreatic cancer development by antagonizing STAT3 activation.
A CREB1-miR-181a-5p loop regulates the pathophysiologic features of bone marrow stromal cells in fibrous dysplasia of bone.
VALD-3, a Schiff base ligand synthesized from o-vanillin derivatives, induces cell cycle arrest and apoptosis in breast cancer cells by inhibiting the Wnt/β-catenin pathway.
Long noncoding RNA GAS5 accelerates diabetic wound healing and promotes lymphangiogenesis via miR-217/Prox1 axis.
Early-senescent bone marrow mesenchymal stem cells promote C2C12 cell myogenic differentiation by preventing the nuclear translocation of FOXO3.
Antagonistic effect of nano-selenium on hepatocyte apoptosis induced by DEHP via PI3K/AKT pathway in chicken liver.
Limonin ameliorates dextran sulfate sodium-induced chronic colitis in mice by inhibiting PERK-ATF4-CHOP pathway of ER stress and NF-κB signaling.
Antileukemic effect of caffeic acid 3,4-dihydroxyphenetyl ester. Evidences for its mechanisms of action.
BCL2 enhances survival of porcine pluripotent stem cells through promoting FGFR2.
S100A8 promotes chemoresistance via augmenting autophagy in B‑cell lymphoma cells.
Fangchinoline exerts antitumour activity by suppressing the EGFR‑PI3K/AKT signalling pathway in colon adenocarcinoma.
FUNDC1-dependent mitophagy induced by tPA protects neurons against cerebral ischemia-reperfusion injury.
Senolytic therapy ameliorates renal fibrosis postacute kidney injury by alleviating renal senescence.
Inhibition of Bcl-2 and Bcl-xL overcomes the resistance to the third-generation EGFR tyrosine kinase inhibitor osimertinib in non-small cell lung cancer.
Inhibition of proliferation-linked signaling cascades with atractylenolide I reduces myofibroblastic phenotype and renal fibrosis.
The neuroprotective effects of phosphocreatine on Amyloid Beta 25-35-induced differentiated neuronal cell death through inhibition of AKT /GSK-3β /Tau/APP /CDK5 pathways in vivo and vitro.
Triptolidenol, isolated from Tripterygium wilfordii, disrupted NF-κB/COX-2 pathway by targeting ATP-binding sites of IKKβ in clear cell renal cell carcinoma.
Toxicity of different zinc oxide nanomaterials and dose-dependent onset and development of Parkinson's disease-like symptoms induced by zinc oxide nanorods.
Qingda granule attenuates angiotensin II-induced cardiac hypertrophy and apoptosis and modulates the PI3K/AKT pathway.
Lidocaine inhibits the metastatic potential of ovarian cancer by blocking Na(V) 1.5-mediated EMT and FAK/Paxillin signaling pathway.
Omeprazole improves chemosensitivity of gastric cancer cells by m6A demethylase FTO-mediated activation of mTORC1 and DDIT3 up-regulation.
Ameliorative effect of recombinant human lactoferrin on the premature ovarian failure in rats after cyclophosphamide treatments.
Aloin protects mice from diet-induced non-alcoholic steatohepatitis via activation of Nrf2/HO-1 signaling.
Cartilage endplate stem cells inhibit intervertebral disc degeneration by releasing exosomes to nucleus pulposus cells to activate Akt/autophagy.
miR-31-5p promotes proliferation and inhibits apoptosis of goat hair follicle stem cells by targeting RASA1/MAP3K1 pathway.
Adiponectin alleviates the symptoms of ischemic renal disease by inhibiting renal cell apoptosis.
Shikonin differentially regulates glucose metabolism via PKM2 and HIF1α to overcome apoptosis in a refractory HCC cell line.
Nephrotoxicity and possible mechanisms of decabrominated diphenyl ethers (BDE-209) exposure to kidney in broilers.
Circ_0001438 participates in the pathogenesis of preeclampsia via the circ_0001438/miR-942/NLRP3 regulatory network.
MiR-133a-3p relieves the oxidative stress induced trophoblast cell apoptosis through the BACH1/Nrf2/HO-1 signaling pathway.
LncRNA SNHG16 contributes to tumor progression via the miR-302b-3p/SLC2A4 axis in pancreatic adenocarcinoma.
ALKBH5-mediated m(6)A demethylation of FOXM1 mRNA promotes progression of uveal melanoma.
PGC1α regulates mitochondrial oxidative phosphorylation involved in cisplatin resistance in ovarian cancer cells via nucleo-mitochondrial transcriptional feedback.
Deficiency of NEAT1 prevented MPP(+)-induced inflammatory response, oxidative stress and apoptosis in dopaminergic SK-N-SH neuroblastoma cells via miR-1277-5p/ARHGAP26 axis.
Alantolactone induces apoptosis in THP-1 cells through STAT3, survivin inhibition, and intrinsic apoptosis pathway.
Bufarenogin induces intrinsic apoptosis via Bax and ANT cooperation.
MicroRNA-520c-3p suppresses vascular endothelium dysfunction by targeting RELA and regulating the AKT and NF-κB signaling pathways.
Curcumin Ameliorates Copper-Induced Neurotoxicity Through Inhibiting Oxidative Stress and Mitochondrial Apoptosis in SH-SY5Y Cells.
Autophagy Induction Contributes to the Neuroprotective Impact of Intermittent Fasting on the Acutely Injured Spinal Cord.
Rosmarinic acid exerts an antagonistic effect on nonalcoholic fatty liver disease by regulating the YAP1/TAZ-PPARγ/PGC-1α signaling pathway.
PRSS55 plays an important role in the structural differentiation and energy metabolism of sperm and is required for male fertility in mice.
Knockdown of long non‑coding RNA ANRIL inhibits the proliferation and promotes the apoptosis of Burkitt lymphoma cells through the TGF‑β1 signaling pathway.
CircCDK8 regulates osteogenic differentiation and apoptosis of PDLSCs by inducing ER stress/autophagy during hypoxia.
Impact of knockdown LincRNA-Cox2 on apoptosis of macrophage infected with Bacillus Calmette-Guérin.
RabGEF1 functions as an oncogene in U251 glioblastoma cells and is involved in regulating AKT and Erk pathways.
RTN1-C mediates cerebral ischemia/reperfusion injury via modulating autophagy.
The novel ZEB1-upregulated protein PRTG induced by Helicobacter pylori infection promotes gastric carcinogenesis through the cGMP/PKG signaling pathway.
Central role of TRAP1 in the ameliorative effect of oleanolic acid on the mitochondrial-mediated and endoplasmic reticulum stress-excitated apoptosis induced by ochratoxin A.
Transcription of MRPL12 regulated by Nrf2 contributes to the mitochondrial dysfunction in diabetic kidney disease.
Downregulation of CD151 induces oxidative stress and apoptosis in trophoblast cells via inhibiting ERK/Nrf2 signaling pathway in preeclampsia.
Rational design and synthesis of 6-aryl-6H-benzo[c]chromenes as non-steroidal progesterone receptor antagonists for use against cancers.
Protective effect of procyanidin A-type dimers against H(2)O(2)-induced oxidative stress in prostate DU145 cells through the MAPKs signaling pathway.
MEG3/MIR-376B-3P/HMGA2 axis is involved in pituitary tumor invasiveness.
Red ginseng has stronger anti-aging effects compared to ginseng possibly due to its regulation of oxidative stress and the gut microbiota.
Myrtenol improves brain damage and promotes angiogenesis in rats with cerebral infarction by activating the ERK1/2 signalling pathway.
Alisol A 24-acetate protects oxygen-glucose deprivation-induced brain microvascular endothelial cells against apoptosis through miR-92a-3p inhibition by targeting the B-cell lymphoma-2 gene.
Kaempferol-induced GPER upregulation attenuates atherosclerosis via the PI3K/AKT/Nrf2 pathway.
Azathioprine pretreatment ameliorates myocardial ischaemia reperfusion injury in diabetic rats by reducing oxidative stress, apoptosis, and inflammation.
Ropivacaine Induces Cell Cycle Arrest in the G0/G1 Phase and Apoptosis of PC12 Cells via Inhibiting Mitochondrial STAT3 Translocation.
Lobetyolin inhibits the proliferation of breast cancer cells via ASCT2 down-regulation-induced apoptosis.
AK003290 Protects Myocardial Cells Against Apoptosis and Promotes Cardiac Function Recovery Via miR-539-3p/ErbB4 Axis in Ischemic-Reperfusion Injury.
Synergistic inhibitory effect of Smo inhibitor jervine and its combination with decitabine can target Hedgehog signaling pathway to inhibit myelodysplastic syndrome cell line.
Exosomal ANXA2 derived from ovarian cancer cells regulates epithelial-mesenchymal plasticity of human peritoneal mesothelial cells.
Danshensu derivative ADTM ameliorates CCl(4)‑induced acute liver injury in mice through inhibiting oxidative stress and apoptosis.
PPP2R2A affects embryonic implantation by regulating the proliferation and apoptosis of Hu sheep endometrial stromal cells.
The endocytic pathway of Pt nanoclusters and their induced apoptosis of A549 and A549/Cis cells through c-Myc/p53 and Bcl-2/caspase-3 signaling pathways.
The XBP1‒MARCH5‒MFN2 Axis Confers Endoplasmic Reticulum Stress Resistance by Coordinating Mitochondrial Fission and Mitophagy in Melanoma.
Activation of NLR family, domain of pyrin containing 3 inflammasome by nitrous oxide through thioredoxin-interacting protein to induce nerve cell injury.
Veratric acid alleviates liver ischemia/reperfusion injury by activating the Nrf2 signaling pathway.
MiR-155-5p suppresses SOX1 to promote proliferation of cholangiocarcinoma via RAF/MEK/ERK pathway.
Long non-coding RNA CRNDE exacerbates NPC advancement mediated by the miR-545-5p/CCND2 axis.
Inhibition of microRNA-30a alleviates vascular remodeling in pulmonary arterial hypertension.
CircSTK40 contributes to recurrent implantation failure via modulating the HSP90/AKT/FOXO1 axis.
CLEC12B suppresses lung cancer progression by inducing SHP-1 expression and inactivating the PI3K/AKT signaling pathway.
Miro1 provides neuroprotection via the mitochondrial trafficking pathway in a rat model of traumatic brain injury.
Recombinant protein Schistosoma japonicum-derived molecule attenuates dextran sulfate sodium-induced colitis by inhibiting miRNA-217-5p to alleviate apoptosis.
Adipose-derived stem cells (ADSCs) inhibit the expression of anti-apoptosis proteins through up-regulation of ATF4 on breast cancer cells.
The miR-223-3p/MAP1B axis aggravates TGF-β-induced proliferation and migration of BPH-1 cells.
Genomic gain of RRS1 promotes hepatocellular carcinoma through reducing the RPL11-MDM2-p53 signaling.
Diosgenin Protects Against Kidney Injury and Mitochondrial Apoptosis Induced by 3-MCPD Through the Regulation of ER Stress, Ca(2+) Homeostasis, and Bcl2 Expression.
6-Shogaol from ginger shows anti-tumor effect in cervical carcinoma via PI3K/Akt/mTOR pathway.
Vitamin E regulates bovine granulosa cell apoptosis via NRF2-mediated defence mechanism by activating PI3K/AKT and ERK1/2 signalling pathways.
Chicoric acid attenuates hyperglycemia-induced endothelial dysfunction through AMPK-dependent inhibition of oxidative/nitrative stresses.
W436, a novel SMART derivative, exhibits anti-hepatocarcinoma activity by inducing apoptosis and G2/M cell cycle arrest in vitro and in vivo and induces protective autophagy.
Tanshinone IIA alleviates acute ethanol-induced myocardial apoptosis mainly through inhibiting the expression of PDCD4 and activating the PI3K/Akt pathway.
EGCG synergizes the therapeutic effect of irinotecan through enhanced DNA damage in human colorectal cancer cells.
Ring finger protein 19A is overexpressed in non-small cell lung cancer and mediates p53 ubiquitin-degradation to promote cancer growth.
TNF-α induces up-regulation of MicroRNA-27a via the P38 signalling pathway, which inhibits intervertebral disc degeneration by targeting FSTL1.
Prenatal exposure to di-n-butyl phthalate induces erectile dysfunction in male adult rats.
Orexin A improves the cognitive impairment induced by chronic intermittent hypoxia in mice.
Vitamin E and selenium supplementation synergistically alleviate the injury induced by hydrogen peroxide in bovine granulosa cells.
SETD4 in the Proliferation, Migration, Angiogenesis, Myogenic Differentiation and Genomic Methylation of Bone Marrow Mesenchymal Stem Cells.
Ferroptosis inducer erastin sensitizes NSCLC cells to celastrol through activation of the ROS-mitochondrial fission-mitophagy axis.
Momordin Ic induces G0/1 phase arrest and apoptosis in colon cancer cells by suppressing SENP1/c-MYC signaling pathway.
CSNK2A1-mediated phosphorylation of HMGA2 modulates cisplatin resistance in cervical cancer.
Renoprotective effects of levosimendan on acute kidney injury following cardiac arrest via anti-inflammation, anti-apoptosis, and ERK activation.
Cypermethrin induces Sertoli cell apoptosis through mitochondrial pathway associated with calcium.
Cyanidin-3-glucoside suppresses the progression of lung adenocarcinoma by downregulating TP53I3 and inhibiting PI3K/AKT/mTOR pathway.
Enriched environment remedies cognitive dysfunctions and synaptic plasticity through NMDAR-Ca(2+)-Activin A circuit in chronic cerebral hypoperfusion rats.
The screening of drug-induced nephrotoxicity using gold nanocluster-based ratiometric fluorescent probes.
Apatinib triggers autophagic and apoptotic cell death via VEGFR2/STAT3/PD-L1 and ROS/Nrf2/p62 signaling in lung cancer.
PDGF-BB/SA/Dex injectable hydrogels accelerate BMSC-mediated functional full thickness skin wound repair by promoting angiogenesis.
Tubeimoside I protects against sepsis-induced cardiac dysfunction via SIRT3.
Identification of Potentially Related Genes and Mechanisms Involved in Skeletal Muscle Atrophy Induced by Excessive Exercise in Zebrafish.
Arsenic-induced autophagy regulates apoptosis in AML-12 cells.
Silencing MAP3K1 expression inhibits the proliferation of goat hair follicle stem cells.
Resveratrol-induced apoptosis is associated with regulating the miR-492/CD147 pathway in malignant melanoma cells.
Expression of long-chain noncoding RNA GAS5 in osteoarthritis and its effect on apoptosis and autophagy of osteoarthritis chondrocytes.
CRSP8 promotes thyroid cancer progression by antagonizing IKKα-induced cell differentiation.
Fusobacterium nucleatum Promotes Cisplatin-Resistance and Migration of Oral Squamous Carcinoma Cells by Up-Regulating Wnt5a-Mediated NFATc3 Expression.
Elevated Secretion of Aldosterone Increases TG/HDL-C Ratio and Potentiates The Ox-LDL-Induced Dysfunction of HUVEC.
MicroRNA-1 affects the development of the neural crest and craniofacial skeleton via the mitochondrial apoptosis pathway.
The miR-136-5p/ROCK1 axis suppresses invasion and migration, and enhances cisplatin sensitivity in head and neck cancer cells.
Dracomolphin A-E, new lignans from Dracocephalum moldavica.
Anti-androgenetic alopecia effect of policosanol from Chinese wax by regulating abnormal hormone levels to suppress premature hair follicle entry into the regression phase.
Change on apoptosis, autophagy and mitochondria of the Harderian gland in Cricetulus barabensis during age.
Construction of Smart Nanotheranostic Platform Bi-Ag@PVP: Multimodal CT/PA Imaging-Guided PDT/PTT for Cancer Therapy.
Coibamide A kills cancer cells through inhibiting autophagy.
Inhibition of Notch1 signaling reduces hepatocyte injury in nonalcoholic fatty liver disease via autophagy.
Reduction of Autophagosome Overload Attenuates Neuronal Cell Death After Traumatic Brain Injury.
Tissue-based metabolomics reveals metabolic biomarkers and potential therapeutic targets for esophageal squamous cell carcinoma.
Kaempferol induces ROS-dependent apoptosis in pancreatic cancer cells via TGM2-mediated Akt/mTOR signaling.
Drug-Loaded, Polyurethane Coated Nitinol Stents for the Controlled Release of Docetaxel for the Treatment of Oesophageal Cancer.
Silencing lncRNA TUG1 Alleviates LPS-Induced Mouse Hepatocyte Inflammation by Targeting miR-140/TNF.
NDUFA4L2 Regulated by HIF-1α Promotes Metastasis and Epithelial-Mesenchymal Transition of Osteosarcoma Cells Through Inhibiting ROS Production.
miR-205 Expression Elevated With EDS Treatment and Induced Leydig Cell Apoptosis by Targeting RAP2B via the PI3K/AKT Signaling Pathway.
miR-124-3p Suppresses the Invasiveness and Metastasis of Hepatocarcinoma Cells via Targeting CRKL.
The Novel Synthetic Triterpene Methyl 3β-O-[4-(2-Aminoethylamino)-4-oxo-butyryl]olean-12-ene-28-oate Inhibits Breast Tumor Cell Growth in Vitro and in Vivo.
RGS12 is required for the maintenance of mitochondrial function during skeletal development.
Anti-inflammation and anti-apoptosis effects of growth arrest-specific protein 6 in acute liver injury induced by LPS/D-GalN in mice.
Effect of Wenshen-Yanggan Decoction on Movement Disorder and Substantia Nigra Dopaminergic Neurons in Mice with Chronic Parkinson's Disease.
Exosomes from Bone Marrow Microenvironment-Derived Mesenchymal Stem Cells Affect CML Cells Growth and Promote Drug Resistance to Tyrosine Kinase Inhibitors.
Methane-Rich Saline Alleviates CA/CPR Brain Injury by Inhibiting Oxidative Stress, Microglial Activation-Induced Inflammatory Responses, and ER Stress-Mediated Apoptosis.
Network Pharmacology-Based Strategy Reveals the Effects of Hedysarum multijugum Maxim.-Radix Salviae Compound on Oxidative Capacity and Cardiomyocyte Apoptosis in Rats with Diabetic Cardiomyopathy.
Neuroprotective Effect of the Inhibitor Salubrinal after Cardiac Arrest in a Rodent Model.
Combination of Dichloroacetate and Atorvastatin Regulates Excessive Proliferation and Oxidative Stress in Pulmonary Arterial Hypertension Development via p38 Signaling.
Nei Endonuclease VIII-Like1 (NEIL1) Inhibits Apoptosis of Human Colorectal Cancer Cells.
The Nrf2/PGC1α Pathway Regulates Antioxidant and Proteasomal Activity to Alter Cisplatin Sensitivity in Ovarian Cancer.
Protective Effects of Cinnamaldehyde against Mesenteric Ischemia-Reperfusion-Induced Lung and Liver Injuries in Rats.
Overexpression of BMPER in Ovarian Cancer and the Mechanism by which It Promotes Malignant Biological Behavior in Tumor Cells.
miR193b Promotes Apoptosis of Gastric Cancer Cells via Directly Mediating the Akt Pathway.
Inhibition of Specificity Protein 1 Is Involved in Phloretin-Induced Suppression of Prostate Cancer.
Silencing of PRDX2 Inhibits the Proliferation and Invasion of Non-Small Cell Lung Cancer Cells.
Alantolactone inhibits cell autophagy and promotes apoptosis via AP2M1 in acute lymphoblastic leukemia.
A novel chalcone derivative has antitumor activity in melanoma by inducing DNA damage through the upregulation of ROS products.
A novel chalcone derivative suppresses melanoma cell growth through targeting Fyn/Stat3 pathway.
miR-454 suppresses the proliferation and invasion of ovarian cancer by targeting E2F6.
Silencing of miR-17-5p suppresses cell proliferation and promotes cell apoptosis by directly targeting PIK3R1 in laryngeal squamous cell carcinoma.
Long non-coding RNA LINC01503 promotes the progression of hepatocellular carcinoma via activating MAPK/ERK pathway.
Downregulation of Cypher induces apoptosis in cardiomyocytes via Akt/p38 MAPK signaling pathway.
Drp1-mediated mitochondrial fission contributes to baicalein-induced apoptosis and autophagy in lung cancer via activation of AMPK signaling pathway.
Mitochondrial KATP channels contribute to the protective effects of hydrogen sulfide against impairment of central chemoreception of rat offspring exposed to maternal cigarette smoke.
Shikonin and 4-hydroxytamoxifen synergistically inhibit the proliferation of breast cancer cells through activating apoptosis signaling pathway in vitro and in vivo.
RNA Binding Protein Motif 3 Inhibits Oxygen-Glucose Deprivation/Reoxygenation-Induced Apoptosis Through Promoting Stress Granules Formation in PC12 Cells and Rat Primary Cortical Neurons.
Induction of Autophagy by Baicalin Through the AMPK-mTOR Pathway Protects Human Skin Fibroblasts from Ultraviolet B Radiation-Induced Apoptosis.
Thymol Isolated from Thymus vulgaris L. Inhibits Colorectal Cancer Cell Growth and Metastasis by Suppressing the Wnt/β-Catenin Pathway.
The knockdown of the sepiapterin reductase gene suppresses the proliferation of breast cancer by inducing ROS-mediated apoptosis.
Huaier Restrains Cholangiocarcinoma Progression in vitro and in vivo Through Modulating lncRNA TP73-AS1 and Inducing Oxidative Stress.
Derlin-1 Promotes the Progression of Human Hepatocellular Carcinoma via the Activation of AKT Pathway.
Connexin 43 Modulates the Cellular Resistance to Paclitaxel via Targeting β-Tubulin in Triple-Negative Breast Cancer.
β-Elemene Enhances the Chemotherapeutic Effect of 5-Fluorouracil in Triple-Negative Breast Cancer via PI3K/AKT, RAF-MEK-ErK, and NF-κB Signaling Pathways.
LncRNA MIR503HG Promotes High-Glucose-Induced Proximal Tubular Cell Apoptosis by Targeting miR-503-5p/Bcl-2 Pathway.
Brevilin A Inhibits STAT3 Signaling and Induces ROS-Dependent Apoptosis, Mitochondrial Stress and Endoplasmic Reticulum Stress in MCF-7 Breast Cancer Cells.
Overexpression of TEM8 promotes ovarian cancer progression via Rac1/Cdc42/JNK and MEK/ERK/STAT3 signaling pathways.
Fenofibrate-induced mitochondrial dysfunction and metabolic reprogramming reversal: the anti-tumor effects in gastric carcinoma cells mediated by the PPAR pathway.
Selaginellin B induces apoptosis and autophagy in pancreatic cancer cells via the JAK2/STAT3 signaling pathway.
LongShengZhi Capsule Attenuates Alzheimer-Like Pathology in APP/PS1 Double Transgenic Mice by Reducing Neuronal Oxidative Stress and Inflammation.
Targeting PIK3CG in Combination with Paclitaxel as a Potential Therapeutic Regimen in Claudin-Low Breast Cancer.
Down-regulation of USP8 Inhibits Cholangiocarcinoma Cell Proliferation and Invasion.
AOC1 Contributes to Tumor Progression by Promoting the AKT and EMT Pathways in Gastric Cancer.
Hyperin Controls the Development and Therapy of Gastric Cancer via Regulating Wnt/β-Catenin Signaling.
Baohuoside I via mTOR Apoptotic Signaling to Inhibit Glioma Cell Growth.
Inhibiting EMT, stemness and cell cycle involved in baicalin-induced growth inhibition and apoptosis in colorectal cancer cells.
Mesenchymal stem/stromal cells-derived IL-6 promotes nasopharyngeal carcinoma growth and resistance to cisplatin via upregulating CD73 expression.
Gambogic acid affects ESCC progression through regulation of PI3K/AKT/mTOR signal pathway.
Knockdown of the long noncoding RNA XIST suppresses glioma progression by upregulating miR-204-5p.
Total saponins from Lilium lancifolium: a promising alternative to inhibit the growth of gastric carcinoma cells.
Oleoylethanolamide Protects Against Acute Liver Injury by Regulating Nrf-2/HO-1 and NLRP3 Pathways in Mice.
Ursodeoxycholic Acid Protects Against Arsenic Induced Hepatotoxicity by the Nrf2 Signaling Pathway.
A Mechanism of Action Study on Danggui Sini Decoction to Discover Its Therapeutic Effect on Gastric Cancer.
Acylated Ghrelin is Protective Against 6-OHDA-induced Neurotoxicity by Regulating Autophagic Flux.
miR-222 Suppresses Immature Porcine Sertoli Cell Growth by Targeting the GRB10 Gene Through Inactivating the PI3K/AKT Signaling Pathway.
miR-149-5p Regulates Goat Hair Follicle Stem Cell Proliferation and Apoptosis by Targeting the CMTM3/AR Axis During Superior-Quality Brush Hair Formation.
An Integrative Pharmacology-Based Analysis of Refined Qingkailing Injection Against Cerebral Ischemic Stroke: A Novel Combination of Baicalin, Geniposide, Cholic Acid, and Hyodeoxycholic Acid.
Sodium Butyrate Abrogates the Growth and Pathogenesis of Mycobacterium bovis via Regulation of Cathelicidin (LL37) Expression and NF-κB Signaling.
α-Cyperone Attenuates H(2)O(2)-Induced Oxidative Stress and Apoptosis in SH-SY5Y Cells via Activation of Nrf2.
Tilianin Extracted From Dracocephalum moldavica L. Induces Intrinsic Apoptosis and Drives Inflammatory Microenvironment Response on Pharyngeal Squamous Carcinoma Cells via Regulating TLR4 Signaling Pathways.
Purmorphamine Attenuates Neuro-Inflammation and Synaptic Impairments After Hypoxic-Ischemic Injury in Neonatal Mice via Shh Signaling.
Dose- and Time-Dependent Cytotoxicity of Carteolol in Corneal Endothelial Cells and the Underlying Mechanisms.
AKT Inhibitor SC66 Inhibits Proliferation and Induces Apoptosis in Human Glioblastoma Through Down-Regulating AKT/β-Catenin Pathway.
Inhibition of JNK-Mediated Autophagy Promotes Proscillaridin A- Induced Apoptosis via ROS Generation, Intracellular Ca(+2) Oscillation and Inhibiting STAT3 Signaling in Breast Cancer Cells.
Targeting BCL10 by small peptides for the treatment of B cell lymphoma.
3D printed intelligent scaffold prevents recurrence and distal metastasis of breast cancer.
Whole-Exome Sequencing Reveals New Potential Mutations Genes for Primary Mucosa-Associated Lymphoid Tissue Lymphoma Arising From the Kidney.
Disulfiram Chelated With Copper Inhibits the Growth of Gastric Cancer Cells by Modulating Stress Response and Wnt/β-catenin Signaling.
Fusobacterium nucleatum Promotes the Development of Ulcerative Colitis by Inducing the Autophagic Cell Death of Intestinal Epithelial.
MicroRNA-1269a Promotes Proliferation and Arrest of Apoptosis of Glioma Cells by Directly Targeting ATRX.
Long Non-coding RNA CCAT1 Acts as an Oncogene and Promotes Sunitinib Resistance in Renal Cell Carcinoma.
Upregulated MELK Leads to Doxorubicin Chemoresistance and M2 Macrophage Polarization via the miR-34a/JAK2/STAT3 Pathway in Uterine Leiomyosarcoma.
Verteporfin Is a Promising Anti-Tumor Agent for Cervical Carcinoma by Targeting Endoplasmic Reticulum Stress Pathway.
Effect of epiberberine from Coptis chinensis Franch on inhibition of tumor growth in MKN-45 xenograft mice.
Cetuximab enhances oridonin-induced apoptosis through mitochondrial pathway and endoplasmic reticulum stress in laryngeal squamous cell carcinoma cells.
GBP1 promotes erlotinib resistance via PGK1‑activated EMT signaling in non‑small cell lung cancer.
Hyperbaric oxygen treatment mitigates liver damage in mice with noise exposure.
Neferine induces apoptosis by modulating the ROS‑mediated JNK pathway in esophageal squamous cell carcinoma.
Cinnamaldehyde protects against rat intestinal ischemia/reperfusion injuries by synergistic inhibition of NF-κB and p53.
Curcumin inhibits the growth of triple-negative breast cancer cells by silencing EZH2 and restoring DLC1 expression.
Musashi2 promotes the progression of pancreatic cancer through a novel ISYNA1-p21/ZEB-1 pathway.
FTO accelerates ovarian cancer cell growth by promoting proliferation, inhibiting apoptosis, and activating autophagy.
Effect of CEACAM6 silencing on the biological behavior of human gallbladder cancer cells.
Mycobacterium tuberculosis infection increases the number of osteoclasts and inhibits osteoclast apoptosis by regulating TNF-α-mediated osteoclast autophagy.
BAIAP2L2 promotes the progression of gastric cancer via AKT/mTOR and Wnt3a/β-catenin signaling pathways.
Synthesis, docking studies and antitumor activity of phenanthroimidazole derivatives as promising c-myc G-quadruplex DNA stabilizers.
LAIR-1 suppresses cell growth of ovarian cancer cell via the PI3K-AKT-mTOR pathway.
Dual Regulation of miR-34a and Notch Signaling in Triple-Negative Breast Cancer by Antibody/miRNA Nanocarriers.
Porphyromonas gingivalis disrupts vascular endothelial homeostasis in a TLR-NF-κB axis dependent manner.
Myricanol 5-fluorobenzyloxy ether regulation of survivin pathway inhibits human lung adenocarcinoma A549 cells growth in vitro.
Targeting DNA to the endoplasmic reticulum efficiently enhances gene delivery and therapy.
Zinc oxide nanoparticles effectively regulate autophagic cell death by activating autophagosome formation and interfering with their maturation.
Reactive oxygen species mediate anlotinib-induced apoptosis via activation of endoplasmic reticulum stress in pancreatic cancer.
α-Cyperone inhibits the proliferation of human cervical cancer HeLa cells via ROS-mediated PI3K/Akt/mTOR signaling pathway.
Inhibition of autophagy enhances timosaponin AIII-induced lung cancer cell apoptosis and anti-tumor effect in vitro and in vivo.
Involvement of JNK/FOXO1 pathway in apoptosis induced by severe hypoxia in porcine granulosa cells.
Downregulation of CDC20 Increases Radiosensitivity through Mcl-1/p-Chk1-Mediated DNA Damage and Apoptosis in Tumor Cells.
The AKT/GSK3-Mediated Slug Expression Contributes to Oxaliplatin Resistance in Colorectal Cancer via Upregulation of ERCC1.
Puerarin ameliorates retinal ganglion cell damage induced by retinal ischemia/reperfusion through inhibiting the activation of TLR4/NLRP3 inflammasome.
Oncogenic gene RGC-32 is a direct target of miR-26b and facilitates tongue squamous cell carcinoma aggressiveness through EMT and PI3K/AKT signalling.
Potential hazardous effects of printing room PM2.5 exposure include promotion of lung inflammation and subsequent injury.
PRDX2 plays an oncogenic role in esophageal squamous cell carcinoma via Wnt/β-catenin and AKT pathways.
Micheliolide suppresses the viability, migration and invasion of U251MG cells via the NF-κB signaling pathway.
Inhibitory effect of Lycium barbarum polysaccharide on sperm damage during cryopreservation.
Long non-coding RNA MEG3 promotes cataractogenesis by upregulating TP53INP1 expression in age-related cataract.
Lowly expressed lncRNA PVT1 suppresses proliferation and advances apoptosis of glioma cells through up-regulating microRNA-128-1-5p and inhibiting PTBP1.
STYK1 promotes autophagy through enhancing the assembly of autophagy-specific class III phosphatidylinositol 3-kinase complex I.
Evaluation of toxicity of halloysite nanotubes and multi-walled carbon nanotubes to endothelial cells in vitro and blood vessels in vivo.
Huoxin pill attenuates myocardial infarction-induced apoptosis and fibrosis via suppression of p53 and TGF-β1/Smad2/3 pathways.
Identification of osalmid metabolic profile and active metabolites with anti-tumor activity in human hepatocellular carcinoma cells.
Empagliflozin improves diabetic renal tubular injury by alleviating mitochondrial fission via AMPK/SP1/PGAM5 pathway.
Hepcidin overexpression in astrocytes alters brain iron metabolism and protects against amyloid-β induced brain damage in mice.
Activation of Sirtuin1 by lyceum barbarum polysaccharides in protection against diabetic cataract.
Rosmarinic Acid Alleviates Inflammation, Apoptosis, and Oxidative Stress through Regulating miR-155-5p in a Mice Model of Parkinson's Disease.
NO66 overexpression rescues ethanol-induced cell apoptosis in human AC16 cardiomyocytes by suppressing PTEN and activating the PI3K/Akt signaling.
BioID-based proteomic analysis of the Bid interactome identifies novel proteins involved in cell-cycle-dependent apoptotic priming.
Hepatoprotective effects of Di Wu Yang Gan: A medicinal food against CCl(4)-induced hepatotoxicity in vivo and in vitro.
Melatonin suppresses ER stress-dependent proapoptotic effects via AMPK in bone mesenchymal stem cells during mitochondrial oxidative damage.
Bta-miR-34b inhibits proliferation and promotes apoptosis via the MEK/ERK pathway by targeting MAP2K1 in bovine primary Sertoli cells.
Polydatin executes anticancer effects against glioblastoma multiforme by inhibiting the EGFR-AKT/ERK1/2/STAT3-SOX2/Snail signaling pathway.
Echinacea polysaccharide alleviates LPS-induced lung injury via inhibiting inflammation, apoptosis and activation of the TLR4/NF-κB signal pathway.
Inhibition of B7-H4 promotes hepatocellular carcinoma cell apoptosis and autophagy through the PI3K signaling pathway.
CaMKII as a key regulator of contrast-induced nephropathy through mPTP opening in HK-2 cells.
Induction of SPARC on Oxidative Stress, Inflammatory Phenotype Transformation, and Apoptosis of Human Brain Smooth Muscle Cells Via TGF-β1-NOX4 Pathway.
miR-877-5p antagonizes the promoting effect of SP on the gastric cancer progression.
miR-130a promotes immature porcine Sertoli cell growth by activating SMAD5 through the TGF-β-PI3K/AKT signaling pathway.
Development of a novel thymidylate synthase (TS) inhibitor capable of up-regulating P53 expression and inhibiting angiogenesis in NSCLC.
Pharmacological Effects of Fasudil on Flap Survival in a Rodent Model.
Mechanical stress regulates autophagic flux to affect apoptosis after spinal cord injury.
Berberine protects against diabetic retinopathy by inhibiting cell apoptosis via deactivation of the NF‑κB signaling pathway.
miR‑155 modulates high glucose‑induced cardiac fibrosis via the Nrf2/HO‑1 signaling pathway.
miR‑183‑5p attenuates cerebral ischemia injury by negatively regulating PTEN.
MicroRNA‑22 regulates autophagy and apoptosis in cisplatin resistance of osteosarcoma.
Agaricus blazei extract (FA-2-b-β) induces apoptosis in chronic myeloid leukemia cells.
Anthocyanins from Aronia melanocarpa Induce Apoptosis in Caco-2 Cells through Wnt/β-Catenin Signaling Pathway.
Extracellular ubiquitin protects cardiomyocytes during ischemia/hypoxia by inhibiting mitochondrial apoptosis pathway through CXCR4.
Pomegranate flower extract bidirectionally regulates the proliferation, differentiation and apoptosis of 3T3-L1 cells through regulation of PPARγ expression mediated by PI3K-AKT signaling pathway.
HAX1 enhances the survival and metastasis of non-small cell lung cancer through the AKT/mTOR and MDM2/p53 signaling pathway.
Mycoplasma bovis-generated reactive oxygen species and induced apoptosis in bovine mammary epithelial cell cultures.
TMEM176A acts as a tumor suppressor gene in pancreatic cancer by inhibiting ERK signaling.
CDK5RAP3, a Novel Nucleoplasmic Shuttle, Deeply Regulates HSF1-Mediated Heat Stress Response and Protects Mammary Epithelial Cells from Heat Injury.
[IL-17A/lL-17RA reduces cisplatin sensitivity of ovarian cancer SKOV3 cells by regulating autophagy].
Sesn2 attenuates the damage of endothelial progenitor cells induced by angiotensin II through regulating the Keap1/Nrf2 signal pathway.
SRT2183 impairs ovarian cancer by facilitating autophagy.
Oxidative stress mediates age-related hypertrophy of ligamentum flavum by inducing inflammation, fibrosis, and apoptosis through activating Akt and MAPK pathways.
Ranolazine protects against diabetic cardiomyopathy by activating the NOTCH1/NRG1 pathway.
Design and synthesis of novel Flavone-based histone deacetylase inhibitors antagonizing activation of STAT3 in breast cancer.
Targeted inhibition of GRP78 by HA15 promotes apoptosis of lung cancer cells accompanied by ER stress and autophagy.
Acupuncture protects against cerebral ischemia-reperfusion injury via suppressing endoplasmic reticulum stress-mediated autophagy and apoptosis.
Hesperidin ameliorates hypobaric hypoxia-induced retinal impairment through activation of Nrf2/HO-1 pathway and inhibition of apoptosis.
Morusin induces apoptosis and autophagy via JNK, ERK and PI3K/Akt signaling in human lung carcinoma cells.
E3 ubiquitin ligase TRIM7 negatively regulates NF-kappa B signaling pathway by degrading p65 in lung cancer.
miR-362 knock-down promotes proliferation and inhibits apoptosis in porcine immature Sertoli cells by targeting the RMI1 gene.
LINC00963 targeting miR-128-3p promotes acute kidney injury process by activating JAK2/STAT1 pathway.
Altered circadian clock as a novel therapeutic target for constant darkness-induced insulin resistance and hyperandrogenism of polycystic ovary syndrome.
Palmatine induces G2/M phase arrest and mitochondrial-associated pathway apoptosis in colon cancer cells by targeting AURKA.
Silencing METTL3 inhibits the proliferation and invasion of osteosarcoma by regulating ATAD2.
KIF2A promotes the progression via AKT signaling pathway and is upregulated by transcription factor ETV4 in human gastric cancer.
MicroRNA-375-3p enhances chemosensitivity to 5-fluorouracil by targeting thymidylate synthase in colorectal cancer.
Pyruvate alleviates high glucose-induced endoplasmic reticulum stress and apoptosis in HK-2 cells.
Astragaloside IV enhances GATA-4 mediated myocardial protection effect in hypoxia/reoxygenation injured H9c2 cells.
Arsenic trioxide ameliorates experimental autoimmune encephalomyelitis in C57BL/6 mice by inducing CD4(+) T cell apoptosis.
MAY, a novel tubulin inhibitor, induces cell apoptosis in A549 and A549/Taxol cells and inhibits epithelial-mesenchymal transition in A549/Taxol cells.
Bismuth Porphyrin Antagonizes Cisplatin-Induced Nephrotoxicity via Unexpected Metallothionein-Independent Mechanisms.
Butyrate alleviates oxidative stress by regulating NRF2 nuclear accumulation and H3K9/14 acetylation via GPR109A in bovine mammary epithelial cells and mammary glands.
MS-275 combined with cisplatin exerts synergistic antitumor effects in human esophageal squamous cell carcinoma cells.
CUL4 E3 ligase regulates the proliferation and apoptosis of lung squamous cell carcinoma and small cell lung carcinoma.
MiR-193b-5p inhibits proliferation and enhances radio-sensitivity by downregulating the AKT/mTOR signaling pathway in tongue cancer.
Rosmarinic acid exerts an anticancer effect on osteosarcoma cells by inhibiting DJ-1 via regulation of the PTEN-PI3K-Akt signaling pathway.
Silencing of TPD52 inhibits proliferation, migration, invasion but induces apoptosis of pancreatic cancer cells by deactivating Akt pathway.
Characterization of HTATIP2 and its role during hair follicle cycles in Angora rabbit.
HJC0152 suppresses human non-small-cell lung cancer by inhibiting STAT3 and modulating metabolism.
Resveratrol protects the integrity of alveolar epithelial barrier via SIRT1/PTEN/p-Akt pathway in methamphetamine-induced chronic lung injury.
Do You Know the Details of Your PAX8 Antibody? Monoclonal PAX8 (MRQ-50) Is Not Expressed in a Series of 45 Medullary Thyroid Carcinomas.
Acrolein-induced apoptosis of smooth muscle cells through NEAT1-Bmal1/Clock pathway and a protection from asparagus extract.
Blockade of HSP70 by VER-155008 synergistically enhances bortezomib-induced cytotoxicity in multiple myeloma.
C. sakazakii activates AIM2 pathway accompanying with excessive ER stress response in mammalian mammary gland epithelium.
Melatonin attenuates doxorubicin-induced cardiotoxicity through preservation of YAP expression.
Dioscin inhibits the growth of human osteosarcoma by inducing G2/M-phase arrest, apoptosis, and GSDME-dependent cell death in vitro and in vivo.
Knockdown of lncRNA MIR503HG suppresses proliferation and promotes apoptosis of non-small cell lung cancer cells by regulating miR-489-3p and miR-625-5p.
CHAF1B induces radioresistance by promoting DNA damage repair in nasopharyngeal carcinoma.
The mechanism of PDA/PEI/5-Fu coated esophageal stent material on inhibiting cancer associated pathological cells.
Layer-by-layer assembled PLGA nanoparticles carrying miR-34a cargo inhibit the proliferation and cell cycle progression of triple-negative breast cancer cells.
MicroRNA-217-5p ameliorates endothelial cell apoptosis induced by ox-LDL by targeting CLIC4.
Novel HSP90-PI3K Dual Inhibitor Suppresses Melanoma Cell Proliferation by Interfering with HSP90-EGFR Interaction and Downstream Signaling Pathways.
High Glucose Induces Mesangial Cell Apoptosis through miR-15b-5p and Promotes Diabetic Nephropathy by Extracellular Vesicle Delivery.
Long non-coding RNA HAL suppresses the migration and invasion of serous ovarian cancer by inhibiting EMT signaling pathway.
Nanoparticle-Mediated Co-Delivery of Notch-1 Antibodies and ABT-737 as a Potent Treatment Strategy for Triple-Negative Breast Cancer.
LncRNA HCP5 promotes cell proliferation and inhibits apoptosis via miR-27a-3p/IGF-1 axis in human granulosa-like tumor cell line KGN.
MicroRNA-145 suppresses gastric cancer progression by targeting Hu-antigen R.
Discovery of novel akt1 inhibitor induces autophagy associated death in hepatocellular carcinoma cells.
4-hydroxybenzo[d]oxazol-2(3H)-one ameliorates LPS/D-GalN-induced acute liver injury by inhibiting TLR4/NF-κB and MAPK signaling pathways in mice.
MANF Promotes Diabetic Corneal Epithelial Wound Healing and Nerve Regeneration by Attenuating Hyperglycemia-Induced Endoplasmic Reticulum Stress.
Dihydromethysticin, a natural molecule from Kava, suppresses the growth of colorectal cancer via the NLRC3/PI3K pathway.
Compositional characterization of Pyrus ussuriensis Maxim and their antioxidant activities and induction of apoptosis in Bel-7402 cell.
Triptolide interrupts rRNA synthesis and induces the RPL23‑MDM2‑p53 pathway to repress lung cancer cells.
Upregulation of miR-219a-5p Decreases Cerebral Ischemia/Reperfusion Injury In Vitro by Targeting Pde4d.
Overexpressed microRNA-494 represses RIPK1 to attenuate hippocampal neuron injury in epilepsy rats by inactivating the NF-κB signaling pathway.
Chemopreventive effect of Betulinic acid via mTOR -Caspases/Bcl2/Bax apoptotic signaling in pancreatic cancer.
lncRNA MIRF Promotes Cardiac Apoptosis through the miR-26a-Bak1 Axis.
SIRT3 increases cisplatin sensitivity of small-cell lung cancer through apoptosis.
Glycosylation end products mediate damage and apoptosis of periodontal ligament stem cells induced by the JNK-mitochondrial pathway.
Radiation-Induced DNMT3B Promotes Radioresistance in Nasopharyngeal Carcinoma through Methylation of p53 and p21.
YBX1 mediates autophagy by targeting p110β and decreasing the sensitivity to cisplatin in NSCLC.
Rosmarinic acid exerts a neuroprotective effect on spinal cord injury by suppressing oxidative stress and inflammation via modulating the Nrf2/HO-1 and TLR4/NF-κB pathways.
Non-Esterified Fatty Acid-Induced Reactive Oxygen Species Mediated Granulosa Cells Apoptosis Is Regulated by Nrf2/p53 Signaling Pathway.
Resveratrol inhibits the malignant progression of hepatocellular carcinoma via MARCH1-induced regulation of PTEN/AKT signaling.
Cyclovirobuxine D inhibits colorectal cancer tumorigenesis via the CTHRC1‑AKT/ERK‑Snail signaling pathway.
4-Phenylbutyrate Prevents Endoplasmic Reticulum Stress-Mediated Apoptosis Induced by Heatstroke in the Intestines of Mice.
PCNP promotes ovarian cancer progression by accelerating β-catenin nuclear accumulation and triggering EMT transition.
CUDC-907, a novel dual PI3K and HDAC inhibitor, in prostate cancer: Antitumour activity and molecular mechanism of action.
lncRNA KCNQ1OT1 knockdown inhibits colorectal cancer cell proliferation, migration and invasiveness via the PI3K/AKT pathway.
Vitamin D3 mediates miR-15a-5p inhibition of liver cancer cell proliferation via targeting E2F3.
ZX-29, a novel ALK inhibitor, induces apoptosis via ER stress in ALK rearrangement NSCLC cells and overcomes cell resistance caused by an ALK mutation.
MicroRNA-26a-5p alleviates neuronal apoptosis and brain injury in intracerebral hemorrhage by targeting RAN binding protein 9.
PD-L1 promotes tumor growth and progression by activating WIP and β-catenin signaling pathways and predicts poor prognosis in lung cancer.
Epigenetic upregulation of HOXC10 in non-small lung cancer cells.
Circ-ADAM9 targeting PTEN and ATG7 promotes autophagy and apoptosis of diabetic endothelial progenitor cells by sponging mir-20a-5p.
Design, synthesis and biological evaluation of homoerythrina alkaloid derivatives bearing a triazole moiety as PARP-1 inhibitors and as potential antitumor drugs.
Withaferin A triggers G2/M arrest and intrinsic apoptosis in glioblastoma cells via ATF4-ATF3-CHOP axis.
Aconitine induces cardiomyocyte damage by mitigating BNIP3-dependent mitophagy and the TNFα-NLRP3 signalling axis.
LncRNA MYCNOS facilitates proliferation and invasion in hepatocellular carcinoma by regulating miR-340.
LINC00365-SCGB2A1 axis inhibits the viability of breast cancer through targeting NF-κB signaling.
Long noncoding RNA CA7-4 promotes autophagy and apoptosis via sponging MIR877-3P and MIR5680 in high glucose-induced vascular endothelial cells.
Long noncoding RNA CASC21 exerts an oncogenic role in colorectal cancer through regulating miR-7-5p/YAP1 axis.
Enhanced UV Resistance Role of Death Domain-Associated Protein in Human MDA-MB-231 Breast Cancer Cells by Regulation of G2 DNA Damage Checkpoint.
Desloratadine, a Novel Antigrowth Reagent for Bladder Cancer.
Knockdown of Rab9 Suppresses the Progression of Gastric Cancer Through Regulation of Akt Signaling Pathway.
Trehalose Alleviates Crystalline Silica-Induced Pulmonary Fibrosis via Activation of the TFEB-Mediated Autophagy-Lysosomal System in Alveolar Macrophages.
Lycorine Induces autophagy-associated apoptosis by targeting MEK2 and enhances vemurafenib activity in colorectal cancer.
Ginsenoside Rk1 induces apoptosis and downregulates the expression of PD-L1 by targeting the NF-κB pathway in lung adenocarcinoma.
Calcium relieves fluoride-induced bone damage through the PI3K/AKT pathway.
A robust TDP-43 knock-in mouse model of ALS.
The Preparation of Ginsenoside Rg5, Its Antitumor Activity against Breast Cancer Cells and Its Targeting of PI3K.
Propofol facilitates migration and invasion of oral squamous cell carcinoma cells by upregulating SNAI1 expression.
The potential of Diosgenin in treating psoriasis: Studies from HaCaT keratinocytes and imiquimod-induced murine model.
Icariin protects human nucleus pulposus cells from hydrogen peroxide-induced mitochondria-mediated apoptosis by activating nuclear factor erythroid 2-related factor 2.
FOXO3/TRIM22 axis abated the antitumor effect of gemcitabine in non-small cell lung cancer via autophagy induction.
Chronic toxicity of methamphetamine: Oxidative remodeling of pulmonary arteries.
Prucalopride inhibits lung cancer cell proliferation, invasion, and migration through blocking of the PI3K/AKT/mTor signaling pathway.
A randomized phase 2 trial of apatinib vs observation as maintenance treatment following first-line induction chemotherapy in extensive- stage small cell lung cancer.
Berberine inhibits proliferation and migration of colorectal cancer cells by downregulation of GRP78.
FGFRL1 affects chemoresistance of small-cell lung cancer by modulating the PI3K/Akt pathway via ENO1.
N-glycosylation of uterine endometrium determines its receptivity.
Pizotifen inhibits the proliferation and invasion of gastric cancer cells.
Targeting of β-Catenin Reverses Radioresistance of Cervical Cancer with the PIK3CA-E545K Mutation.
1,3-Dicaffeoylquinic acid targeting 14-3-3 tau suppresses human breast cancer cell proliferation and metastasis through IL6/JAK2/PI3K pathway.
Transforming growth factor-β1-regulated Fas/FasL pathway activation suppresses nucleus pulposus cell apoptosis in an inflammatory environment.
Bruceine D induces lung cancer cell apoptosis and autophagy via the ROS/MAPK signaling pathway in vitro and in vivo.
Intravenously Infusing the Secretome of Adipose-Derived Mesenchymal Stem Cells Ameliorates Neuroinflammation and Neurological Functioning After Traumatic Brain Injury.
Microcystin-leucine-arginine induced neurotoxicity by initiating mitochondrial fission in hippocampal neurons.
Epigenetic silencing of IGFBPL1 promotes esophageal cancer growth by activating PI3K-AKT signaling.
MiR-21 modulates the polarization of macrophages and increases the effects of M2 macrophages on promoting the chemoresistance of ovarian cancer.
Britanin Exhibits Potential Inhibitory Activity on Human Prostate Cancer Cell Lines Through PI3K/Akt/NF-κB Signaling Pathways.
Positive regulation of the CREB phosphorylation via JNK-dependent pathway prevents antimony-induced neuronal apoptosis in PC12 cell and mice brain.
Ursolic acid derivative UA232 evokes apoptosis of lung cancer cells induced by endoplasmic reticulum stress.
Protective effect of hydroxysafflor yellow A on dopaminergic neurons against 6-hydroxydopamine, activating anti-apoptotic and anti-neuroinflammatory pathways.
Anti-tumour activity of zinc ionophore pyrithione in human ovarian cancer cells through inhibition of proliferation and migration and promotion of lysosome-mitochondrial apoptosis.
Synergistic antitumor activity of sorafenib and artesunate in hepatocellular carcinoma cells.
Alpha-fetoprotein accelerates the progression of hepatocellular carcinoma by promoting Bcl-2 gene expression through an RA-RAR signalling pathway.
Associations between Huwe1 and autophagy in rat cerebral neuron oxygen‑glucose deprivation and reperfusion injury.
Synchrotron FTIR microspectroscopy revealed apoptosis-induced biomolecular changes of cholangiocarcinoma cells treated with ursolic acid.
Microcystin-LR exposure results in aberrant spindles and induces apoptosis in porcine oocytes.
Silibinin ameliorats H(2)O(2)-induced cell apoptosis and oxidative stress response by activating Nrf2 signaling in trophoblast cells.
MicroRNA (MiR)-301a-3p regulates the proliferation of esophageal squamous cells via targeting PTEN.
Latcripin-7A, derivative of Lentinula edodes C(91-3), reduces migration and induces apoptosis, autophagy, and cell cycle arrest at G(1) phase in breast cancer cells.
Ssc-miR-21-5p regulates endometrial epithelial cell proliferation, apoptosis and migration via the PDCD4/AKT pathway.
Silencing of lncRNA MIAT alleviates LPS-induced pneumonia via regulating miR-147a/NKAP/NF-κB axis.
Exogenous hydrogen sulfide inhibits apoptosis by regulating endoplasmic reticulum stress-autophagy axis and improves myocardial reconstruction after acute myocardial infarction.
An SGLT2 inhibitor modulates SHH expression by activating AMPK to inhibit the migration and induce the apoptosis of cervical carcinoma cells.
Overexpression of Mucin 1 Suppresses the Therapeutical Efficacy of Disulfiram against Canine Mammary Tumor.
Transplanting Rac1-silenced bone marrow mesenchymal stem cells promote neurological function recovery in TBI mice.
Curcumin protects rat hippocampal neurons against pseudorabies virus by regulating the BDNF/TrkB pathway.
Serine-70 phosphorylated Bcl-2 prevents oxidative stress-induced DNA damage by modulating the mitochondrial redox metabolism.
Exosome-mediated Hic-5 regulates proliferation and apoptosis of osteosarcoma via Wnt/β-catenin signal pathway.
Combined toxic effects of CBNPs and Pb on rat alveolar macrophage apoptosis and autophagy flux.
Polyphyllin I suppresses proliferation and promotes apoptosis of gastric cancer cell by inhibiting stat3 phosphorylation.
Knockdown of interferon-induced transmembrane protein 1 inhibited proliferation, induced cell cycle arrest and apoptosis, and suppressed MAPK signaling pathway in pancreatic cancer cells.
Norfloxacin induces apoptosis and necroptosis in human corneal epithelial cells.
Blocking Parkin/PINK1-mediated mitophagy sensitizes hepatocellular carcinoma cells to sanguinarine-induced mitochondrial apoptosis.
Metabolomic profiling reveals similar cytotoxic effects and protective functions of quercetin during deoxynivalenol- and 15-acetyl deoxynivalenol-induced cell apoptosis.
Nicotinamide N-methyltransferase decreases 5-fluorouracil sensitivity in human esophageal squamous cell carcinoma through metabolic reprogramming and promoting the Warburg effect.
WWP2 ameliorates acute kidney injury by mediating p53 ubiquitylation and degradation.
Effects of PYRIN-containing Apaf1-like protein 1 on isoflurane-induced postoperative cognitive dysfunction in aged rats.
Prazosin inhibits the proliferation, migration and invasion, but promotes the apoptosis of U251 and U87 cells via the PI3K/AKT/mTOR signaling pathway.
Midazolam contributes to neuroprotection against hypoxia/reoxygenation-induced brain injury in neonatal rats via regulation of EAAT2.
Baohuoside-1 targeting mTOR inducing apoptsis to inhibit hepatocellular carcinoma proliferation, invasion and migration.
Fraxetin inhibits the growth of colon adenocarcinoma cells via the Janus kinase 2/signal transducer and activator of transcription 3 signalling pathway.
Activation of the Hedgehog Pathway Promotes Recovery of Neurological Function After Traumatic Brain Injury by Protecting the Neurovascular Unit.
IL13Rα1 protects against rheumatoid arthritis by combating the apoptotic resistance of fibroblast-like synoviocytes.
S100A8 transported by SEC23A inhibits metastatic colonization via autocrine activation of autophagy.
A mitochondria-targeted anticancer nanoplatform with deep penetration for enhanced synergistic sonodynamic and starvation therapy.
A Novel Pharmacological Approach to Enhance the Integrity and Accelerate Restitution of the Intestinal Epithelial Barrier.
Upregulation of circ-0000745 in acute lymphoblastic leukemia enhanced cell proliferation by activating ERK pathway.
Antagomirs targeting miR-142-5p attenuate pilocarpine-induced status epilepticus in mice.
Bcl2 inhibitor ABT737 reverses the Warburg effect via the Sirt3-HIF1α axis to promote oxidative stress-induced apoptosis in ovarian cancer cells.
Protective function of exosomes from adipose tissue-derived mesenchymal stem cells in acute kidney injury through SIRT1 pathway.
Inhibiting pannexin-1 alleviates sepsis-induced acute kidney injury via decreasing NLRP3 inflammasome activation and cell apoptosis.
Therapeutic mechanism of human neural stem cell-derived extracellular vesicles against hypoxia-reperfusion injury in vitro.
Oxymatrine protects neonatal rat against hypoxic-ischemic brain damage via PI3K/Akt/GSK3β pathway.
MicroRNA-760 inhibits cell viability and migration through down-regulating BST2 in gastric cancer.
RETRACTED: MicroRNA-208-5p regulates myocardial injury of sepsis mice via targeting SOCS2-mediated NF-κB/HIF-1α pathway.
Hydrogen sulfide inhibits cigarette smoke-induced inflammation and injury in alveolar epithelial cells by suppressing PHD2/HIF-1α/MAPK signaling pathway.
MicroRNA-378-3p/5p represses proliferation and induces apoptosis of oral squamous carcinoma cells via targeting KLK4.
CCN5 inhibits proliferation and promotes apoptosis of oral squamous cell carcinoma cells.
Identification of a 3,3-difluorinated tetrahydropyridinol compound as a novel antitumor agent for hepatocellular carcinoma acting via cell cycle arrest through disturbing CDK7-mediated phosphorylation of Cdc2.
MTH1 Inhibitor TH287 Suppresses Gastric Cancer Development Through the Regulation of PI3K/AKT Signaling.
Organic anion transporters and PI3K-AKT-mTOR pathway mediate the synergistic anticancer effect of pemetrexed and rhein.
Estradiol-17β regulates proliferation and apoptosis of sheep endometrial epithelial cells by regulating the relative abundance of YAP1.
Prazosin inhibits the proliferation and survival of acute myeloid leukaemia cells through down-regulating TNS1.
MiR-664 Protects Against UVB Radiation-Induced HaCaT Cell Damage via Downregulating ARMC8.
Deferasirox protects against hydrogen peroxide-induced cell apoptosis by inhibiting ubiquitination and degradation of p21(WAF1/CIP1).
Resveratrol Attenuates Aflatoxin B(1)-Induced ROS Formation and Increase of m(6)A RNA Methylation.
Doxorubicin-polyglycerol-nanodiamond conjugates disrupt STAT3/IL-6-mediated reciprocal activation loop between glioblastoma cells and astrocytes.
MicroRNA-16 participates in the cell cycle alteration of HepG2 cells induced by MC-LR.
MYCN-mediated regulation of the HES1 promoter enhances the chemoresistance of small-cell lung cancer by modulating apoptosis.
Oncogenic MSH6-CXCR4-TGFB1 Feedback Loop: A Novel Therapeutic Target of Photothermal Therapy in Glioblastoma Multiforme.
A novel STAT3 inhibitor, HJC0152, exerts potent antitumor activity in glioblastoma.
Cinobufagin Promotes Cell Cycle Arrest and Apoptosis to Block Human Esophageal Squamous Cell Carcinoma Cells Growth via the p73 Signalling Pathway.
Gefitinib-coated balloon inhibits the excessive hyperplasia of intima after vascular injuries through PI3K/AKT pathway.
LncRNA ZFAS1 promotes proliferation and migration and inhibits apoptosis in nasopharyngeal carcinoma via the PI3K/AKT pathway in vitro.
Long noncoding RNA glutathione peroxidase 3-antisense inhibits lens epithelial cell apoptosis by upregulating glutathione peroxidase 3 expression in age-related cataract.
Down-regulation of miR-30b-5p protects cardiomyocytes against hypoxia-induced injury by targeting Aven.
Therapeutic Effects of Human Urine-Derived Stem Cells in a Rat Model of Cisplatin-Induced Acute Kidney Injury In Vivo and In Vitro.
Phosphocreatine Improves Cardiac Dysfunction by Normalizing Mitochondrial Respiratory Function through JAK2/STAT3 Signaling Pathway In Vivo and In Vitro.
Methane-Rich Saline: A Potential Resuscitation Fluid for Hemorrhagic Shock.
Oleic Acid Protects against Hepatic Ischemia and Reperfusion Injury in Mice by Inhibiting AKT/mTOR Pathways.
Carnosine Protects Mouse Podocytes from High Glucose Induced Apoptosis through PI3K/AKT and Nrf2 Pathways.
Alleviation of Hepatic Ischemia Reperfusion Injury by Oleanolic Acid Pretreating via Reducing HMGB1 Release and Inhibiting Apoptosis and Autophagy.
Nrf2/Keap1/ARE Signaling Mediated an Antioxidative Protection of Human Placental Mesenchymal Stem Cells of Fetal Origin in Alveolar Epithelial Cells.
Jiawei Foshou San Induces Apoptosis in Ectopic Endometrium Based on Systems Pharmacology, Molecular Docking, and Experimental Evidence.
Overexpression of CD59 inhibits apoptosis of T-acute lymphoblastic leukemia via AKT/Notch1 signaling pathway.
Epigallocatechin-3-gallate inhibits the growth and increases the apoptosis of human thyroid carcinoma cells through suppression of EGFR/RAS/RAF/MEK/ERK signaling pathway.
Degradation of long non-coding RNA-CIR decelerates proliferation, invasion and migration, but promotes apoptosis of osteosarcoma cells.
Sevoflurane inhibits the progression of ovarian cancer through down-regulating stanniocalcin 1 (STC1).
LncRNA-LET inhibits cell growth of clear cell renal cell carcinoma by regulating miR-373-3p.
PPAR δ inhibition protects against palmitic acid-LPS induced lipidosis and injury in cultured hepatocyte L02 cell.
NFAT5 is Regulated by p53/miR-27a Signal Axis and Promotes Mouse Ovarian Granulosa Cells Proliferation.
Muscle Injury Associated Elevated Oxidative Stress and Abnormal Myogenesis in Patients with Idiopathic Scoliosis.
The ginsenoside Rk3 exerts anti-esophageal cancer activity in vitro and in vivo by mediating apoptosis and autophagy through regulation of the PI3K/Akt/mTOR pathway.
Celecoxib enhances the sensitivity of non-small-cell lung cancer cells to radiation-induced apoptosis through downregulation of the Akt/mTOR signaling pathway and COX-2 expression.
Multi-Walled Carbon Nanotubes (MWCNTs) Activate Apoptotic Pathway Through ER Stress: Does Surface Chemistry Matter?
Synergism of cisplatin-oleanolic acid co-loaded calcium carbonate nanoparticles on hepatocellular carcinoma cells for enhanced apoptosis and reduced hepatotoxicity.
Catalpol prevents denervated muscular atrophy related to the inhibition of autophagy and reduces BAX/BCL2 ratio via mTOR pathway.
Gatifloxacin inducing apoptosis of stromal fibroblasts through cross-talk between caspase-dependent extrinsic and intrinsic pathways.
TNIP1 Inhibits Proliferation And Promotes Apoptosis In Clear Cell Renal Carcinoma Through Targeting C/Ebpβ.
RGS4 Regulates Proliferation And Apoptosis Of NSCLC Cells Via microRNA-16 And Brain-Derived Neurotrophic Factor.
Long noncoding RNA UBE2R2-AS1 promotes glioma cell apoptosis via targeting the miR-877-3p/TLR4 axis.
Effects of Vitamin K3 Combined with UVB on the Proliferation and Apoptosis of Cutaneous Squamous Cell Carcinoma A431 Cells.
miR-7 Reverses Breast Cancer Resistance To Chemotherapy By Targeting MRP1 And BCL2.
DHT deteriorates the progression of monocrotaline-induced pulmonary arterial hypertension: effects of endogenous and exogenous androgen.
Hypoxia induces HT-22 neuronal cell death via Orai1/CDK5 pathway-mediated Tau hyperphosphorylation.
Silencing of lncRNA HOXA11-AS inhibits cell migration, invasion, proliferation, and promotes apoptosis in human glioma cells via upregulating microRNA-125a: in vitro and in vivo studies.
TMEFF1 overexpression and its mechanism for tumor promotion in ovarian cancer.
BHLHE41 promotes U87 and U251 cell proliferation via ERK/cyclinD1 signaling pathway.
siPRDX2-elevated DNM3 inhibits the proliferation and metastasis of colon cancer cells via AKT signaling pathway.
UNBS5162 and amonafide inhibits tumor progression in human melanoma by the AKT/mTOR pathway.
Baohuoside I Inhibits the Proliferation of Pancreatic Cancer Cells via mTOR/S6K1-Caspases/Bcl2/Bax Apoptotic Signaling.
Peptide V3 Inhibits the Growth of Human Hepatocellular Carcinoma by Inhibiting the Ras/Raf/MEK/ERK Signaling Pathway.
Lyn Kinase Promotes the Proliferation of Malignant Melanoma Cells through Inhibition of Apoptosis and Autophagy via the PI3K/Akt Signaling Pathway.
Methylation of SLFN11 promotes gastric cancer growth and increases gastric cancer cell resistance to cisplatin.
Lin28b is involved in curcumin-reversed paclitaxel chemoresistance and associated with poor prognosis in hepatocellular carcinoma.
A Novel Resveratrol-Arsenic Trioxide Combination Treatment Synergistically Induces Apoptosis of Adriamycin-Selected Drug-Resistant Leukemia K562 Cells.
SIRT5 Promotes Hepatocellular Carcinoma Progression by Regulating Mitochondrial Apoptosis.
PINK1/Parkin-Mediated Mitophagy Regulation by Reactive Oxygen Species Alleviates Rocaglamide A-Induced Apoptosis in Pancreatic Cancer Cells.
Resveratrol Protects Against Post-Contrast Acute Kidney Injury in Rabbits With Diabetic Nephropathy.
Diosbulbin B-Induced Mitochondria-Dependent Apoptosis in L-02 Hepatocytes is Regulated by Reactive Oxygen Species-Mediated Autophagy.
The Anti-proliferative Activity of GnRH Through Downregulation of the Akt/ERK Pathways in Pancreatic Cancer.
Prazosin inhibits the growth and mobility of osteosarcoma cells.
Knockdown of SP1/Syncytin1 axis inhibits the proliferation and metastasis through the AKT and ERK1/2 signaling pathways in non-small cell lung cancer.
miR-671-5p Inhibits Tumor Proliferation by Blocking Cell Cycle in Osteosarcoma.
PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation.
Bavachinin exhibits antitumor activity against non‑small cell lung cancer by targeting PPARγ.
Sonic hedgehog pathway mediates genistein inhibition of renal cancer stem cells.
Association between CIRP expression and hypoxic-ischemic brain injury in neonatal rats.
Functional daidzein enhances the anticancer effect of topotecan and reverses BCRP-mediated drug resistance in breast cancer.
HOXA11-AS regulates JAK-STAT pathway by miR-15a-3p/STAT3 axis to promote the growth and metastasis in liver cancer.
The oncogenic role of CB2 in the progression of non-small-cell lung cancer.
Long non-coding RNA linc00645 promotes TGF-β-induced epithelial-mesenchymal transition by regulating miR-205-3p-ZEB1 axis in glioma.
Targeting the IL-1β/IL-1Ra pathways for the aggregation of human islet amyloid polypeptide in an ex vivo organ culture system of the intervertebral disc.
miR-375-3p suppresses tumorigenesis and partially reverses chemoresistance by targeting YAP1 and SP1 in colorectal cancer cells.
αB-crystallin (CRYAB) regulates the proliferation, apoptosis, synthesis and degradation of extracellular matrix of chondrocytes in osteoarthritis.
Cypermethrin exposure reduces the ovarian reserve by causing mitochondrial dysfunction in granulosa cells.
Corticosterone Excess-Mediated Mitochondrial Damage Induces Hippocampal Neuronal Autophagy in Mice Following Cold Exposure.
Knockdown of METTL14 inhibits the growth and invasion of cervical cancer.
Bromodomain inhibitor jq1 induces cell cycle arrest and apoptosis of glioma stem cells through the VEGF/PI3K/AKT signaling pathway.
Paip1 Indicated Poor Prognosis in Cervical Cancer and Promoted Cervical Carcinogenesis.
The protective effect of Cordycepin on diabetic nephropathy through autophagy induction in vivo and in vitro.
Babao Dan induces gastric cancer cell apoptosis via regulating MAPK and NF-κB signaling pathways.
Downregulation of nicotinamide N-methyltransferase inhibits migration and epithelial-mesenchymal transition of esophageal squamous cell carcinoma via Wnt/β-catenin pathway.
HMQ‑T‑F2 suppresses migration of the human cervical cancer HeLa cells by reversing EMT via the PI3K/Akt signaling pathway.
Fibrin matrix containing high-dose calcitriol promotes the apoptosis of gastric cancer cells by sustainably releasing calcitrol and D-dimer.
Autophagy protects HUVECs against ER stress-mediated apoptosis under simulated microgravity.
LncRNA ADPGK-AS1 regulated cell proliferation, invasion, migration and apoptosis via targeting miR-542-3p in osteosarcoma.
Cisplatin decreases cyclin D2 expression via upregulating miR‑93 to inhibit lung adenocarcinoma cell growth.
Cleavage and polyadenylation specific factor 4 promotes colon cancer progression by transcriptionally activating hTERT.
Downregulation of XBP1 decreases serous ovarian cancer cell viability and enhances sensitivity to oxidative stress by increasing intracellular ROS levels.
NKAP functions as an oncogene in Ewing sarcoma cells partly through the AKT signaling pathway.
Ginsenoside Rg5 induces G2/M phase arrest, apoptosis and autophagy via regulating ROS-mediated MAPK pathways against human gastric cancer.
Disocin prevents postmenopausal atherosclerosis in ovariectomized LDLR-/- mice through a PGC-1α/ERα pathway leading to promotion of autophagy and inhibition of oxidative stress, inflammation and apoptosis.
Qingjie Fuzheng Granule attenuates 5-fluorouracil-induced intestinal mucosal damage.
Fractionated irradiation of right thorax induces abscopal damage on testes leading to decline in fertility.
Induction of Chemerin on Autophagy and Apoptosis in Dairy Cow Mammary Epithelial Cells.
Functional genetic variants of RUVBL1 predict overall survival of Chinese patients with epithelial ovarian cancer.
γ-Oryzanol alleviates acetaminophen-induced liver injury: roles of modulating AMPK/GSK3β/Nrf2 and NF-κB signaling pathways.
Oxidation Stress-Mediated MAPK Signaling Pathway Activation Induces Neuronal Loss in the CA1 and CA3 Regions of the Hippocampus of Mice Following Chronic Cold Exposure.
Quetiapine induces myocardial necroptotic cell death through bidirectional regulation of cannabinoid receptors.
Enhancing autophagy by down-regulating GSK-3β alleviates cisplatin-induced ototoxicity in vivo and in vitro.
Dysregulated expression of ACTN4 contributes to endothelial cell injury via the activation of the p38-MAPK/p53 apoptosis pathway in preeclampsia.
Piperine as a neuroprotective functional component in rats with cerebral ischemic injury.
Tannic acid synergistically enhances the anticancer efficacy of cisplatin on liver cancer cells through mitochondria‑mediated apoptosis.
Dehydrogenase/reductase SDR family member 2 silencing sensitizes an oxaliplatin‑resistant cell line to oxaliplatin by inhibiting excision repair cross‑complementing group 1 protein expression.
Diabetes aggravates renal ischemia and reperfusion injury in rats by exacerbating oxidative stress, inflammation, and apoptosis.
Nonviral Delivery of GRIM-19 Gene Inhibits Tumor Growth with Reduced Local and Systemic Complications.
Impaired calcium homeostasis via advanced glycation end products promotes apoptosis through endoplasmic reticulum stress in human nucleus pulposus cells and exacerbates intervertebral disc degeneration in rats.
Iron dysregulation in vascular dementia: Focused on the AMPK/autophagy pathway.
Silencing Huwe1 reduces apoptosis of cortical neurons exposed to oxygen-glucose deprivation and reperfusion.
[Exogenous hydrogen sulfide improves erectile dysfunction by inhibiting apoptosis of corpus cavernosum smooth muscle cells in rats with cavernous nerve injury].
Targetting an LncRNA P5848-ENO1 axis inhibits tumor growth in hepatocellular carcinoma.
Sulforaphane Mediates Glutathione Depletion via Polymeric Nanoparticles to Restore Cisplatin Chemosensitivity.
Viral Nonstructural Protein 1 Induces Mitochondrion-Mediated Apoptosis in Mink Enteritis Virus Infection.
Cardioprotective effects of galectin-3 inhibition against ischemia/reperfusion injury.
A novel ALK inhibitor ZYY inhibits Karpas299 cell growth in vitro and in a mouse xenograft model and induces protective autophagy.
Inhibition of Bcl-2 Synergistically Enhances the Antileukemic Activity of Midostaurin and Gilteritinib in Preclinical Models of FLT3-Mutated Acute Myeloid Leukemia.
The protective effect of oleanolic acid on NMDA-induced MLE-12 cells apoptosis and lung injury in mice by activating SIRT1 and reducing NF-κB acetylation.
Protective effects of levo-tetrahydropalmatine on hepatic ischemia/reperfusion injury are mediated by inhibition of the ERK/NF-κB pathway.
Activation of Nrf2 signaling by Icariin protects against 6-OHDA-induced neurotoxicity.
Astragaloside IV attenuates myocardial ischemia/reperfusion injury in rats via inhibition of calcium-sensing receptor-mediated apoptotic signaling pathways.
Dehydroepiandrosterone stimulates inflammation and impairs ovarian functions of polycystic ovary syndrome.
1,7-Bis(4-hydroxyphenyl)-1,4-heptadien-3-one induces lung cancer cell apoptosis via the PI3K/Akt and ERK1/2 pathways.
MARCH1 encourages tumour progression of hepatocellular carcinoma via regulation of PI3K-AKT-β-catenin pathways.
Establishment and characterization of a radiation-induced dermatitis rat model.
SSRP1 promotes colorectal cancer progression and is negatively regulated by miR-28-5p.
Nano hydroxyapatite induces glioma cell apoptosis by suppressing NF-κB signaling pathway.
Exogenous testosterone alleviates cardiac fibrosis and apoptosis via Gas6/Axl pathway in the senescent mice.
USP36 protects proximal tubule cells from ischemic injury by stabilizing c-Myc and SOD2.
LncRNA HMMR-AS1 promotes proliferation and metastasis of lung adenocarcinoma by regulating MiR-138/sirt6 axis.
CircRNA_014511 affects the radiosensitivity of bone marrow mesenchymal stem cells by binding to miR-29b-2-5p.
Triptolide prevents proliferation and migration of Esophageal Squamous Cell Cancer via MAPK/ERK signaling pathway.
Retinoic Acid-Related Orphan Receptor C Regulates Proliferation, Glycolysis, and Chemoresistance via the PD-L1/ITGB6/STAT3 Signaling Axis in Bladder Cancer.
Gambogic acid attenuates liver fibrosis by inhibiting the PI3K/AKT and MAPK signaling pathways via inhibiting HSP90.
Estrogen-related receptor-α mediates puromycin aminonucleoside-induced mesangial cell apoptosis and inflammatory injury.
The preoperative neutrophil-to-lymphocyte ratio is not a marker of prostate cancer characteristics but is an independent predictor of biochemical recurrence in patients receiving radical prostatectomy.
Hepatoprotective effects and structure-activity relationship of five flavonoids against lipopolysaccharide/d-galactosamine induced acute liver failure in mice.
Combined inhibition of sonic Hedgehog signaling and histone deacetylase is an effective treatment for liver cancer.
Radiosensitization of esophageal carcinoma cells by knockdown of HMGB1 expression.
XPC inhibition rescues cisplatin resistance via the Akt/mTOR signaling pathway in A549/DDP lung adenocarcinoma cells.
Betaine protects against heat exposure-induced oxidative stress and apoptosis in bovine mammary epithelial cells via regulation of ROS production.
UNBS5162 inhibits SKOV3 ovarian cancer cell proliferation by regulating the PI3K/AKT signalling pathway.
Nuciferine inhibits the progression of glioblastoma by suppressing the SOX2-AKT/STAT3-Slug signaling pathway.
STAT1-mediated inhibition of FOXM1 enhances gemcitabine sensitivity in pancreatic cancer.
Downregulation of TIMP2 attenuates sepsis-induced AKI through the NF-κb pathway.
The attenuation of HIV-1 Tat-induced neurotoxicity by Salvianic acid A and Danshen granule.
Effects of okadaic acid and hematein on human lung adenocarcinoma A549 cells and responses of mitochondria and endoplasmic reticulum apoptosis pathways.
Acid sphingomyelinase mediates the noise-induced liver disorder in mice.
Effect of Gpx3 gene silencing by siRNA on apoptosis and autophagy in chicken cardiomyocytes.
Venetoclax Synergistically Enhances the Anti-leukemic Activity of Vosaroxin Against Acute Myeloid Leukemia Cells Ex Vivo.
Cortisol Excess-Mediated Mitochondrial Damage Induced Hippocampal Neuronal Apoptosis in Mice Following Cold Exposure.
NLRP3 inflammasome activates interleukin-23/interleukin-17 axis during ischaemia-reperfusion injury in cerebral ischaemia in mice.
The long non-coding RNA H19 induces hypoxia/reoxygenation injury by up-regulating autophagy in the hepatoma carcinoma cells.
Design, synthesis and biological evaluation of novel uracil derivatives bearing 1, 2, 3-triazole moiety as thymidylate synthase (TS) inhibitors and as potential antitumor drugs.
Anti-inflammatory and antitumour activity of various extracts and compounds from the fruits of Piper longum L.
APS could potentially activate hepatic insulin signaling in HFD-induced IR mice.
p57KIP2‑mediated inhibition of human trophoblast apoptosis and promotion of invasion in vitro.
Protein kinase RNA-like ER kinase/eukaryotic translation initiation factor 2α pathway attenuates tumor necrosis factor alpha-induced apoptosis in nucleus pulposus cells by activating autophagy.
Chlorogenic acid: A potent molecule that protects cardiomyocytes from TNF-α-induced injury via inhibiting NF-κB and JNK signals.
Melatonin prevents lung injury by regulating apelin 13 to improve mitochondrial dysfunction.
A novel hydrogen sulfide-releasing donor, HA-ADT, suppresses the growth of human breast cancer cells through inhibiting the PI3K/AKT/mTOR and Ras/Raf/MEK/ERK signaling pathways.
Suv39h1 promotes facet joint chondrocyte proliferation by targeting miR-15a/Bcl2 in idiopathic scoliosis patients.
Nek2 augments sorafenib resistance by regulating the ubiquitination and localization of β-catenin in hepatocellular carcinoma.
Discovery of N-phenyl-(2,4-dihydroxypyrimidine-5-sulfonamido) phenylurea-based thymidylate synthase (TS) inhibitor as a novel multi-effects antitumor drugs with minimal toxicity.
Knockdown ATG4C inhibits gliomas progression and promotes temozolomide chemosensitivity by suppressing autophagic flux.
Toxicological exploration of peptide-based cationic liposomes in siRNA delivery.
NPRL2 enhances autophagy and the resistance to Everolimus in castration-resistant prostate cancer.
Ginsenoside Compound K Regulates Amyloid β via the Nrf2/Keap1 Signaling Pathway in Mice with Scopolamine Hydrobromide-Induced Memory Impairments.
Suppressive effect mediated by human adipose-derived stem cells on T cells involves the activation of JNK.
Apoptosis induced by ursodeoxycholic acid in human melanoma cells through the mitochondrial pathway.
BPTF promotes hepatocellular carcinoma growth by modulating hTERT signaling and cancer stem cell traits.
Nischarin attenuates apoptosis induced by oxidative stress in PC12 cells.
MiR-181b-5p modulates chemosensitivity of glioma cells to temozolomide by targeting Bcl-2.
Human amnion-derived mesenchymal stem cell (hAD-MSC) transplantation improves ovarian function in rats with premature ovarian insufficiency (POI) at least partly through a paracrine mechanism.
Secalonic Acid-F, a Novel Mycotoxin, Represses the Progression of Hepatocellular Carcinoma via MARCH1 Regulation of the PI3K/AKT/β-catenin Signaling Pathway.
Anti-breast Cancer Activity of SPG-56 from Sweet Potato in MCF-7 Bearing Mice in Situ through Promoting Apoptosis and Inhibiting Metastasis.
A phenanthroline derivative enhances radiosensitivity of hepatocellular carcinoma cells by inducing mitochondria-dependent apoptosis.
Autophagy and Apoptosis Interact to Modulate T-2 Toxin-Induced Toxicity in Liver Cells.
SIRT1 downregulation mediated Manganese-induced neuronal apoptosis through activation of FOXO3a-Bim/PUMA axis.
CpG Oligodeoxynucleotide Promotes Apoptosis of Human Bladder Cancer T24 Cells Via Inhibition of the Antiapoptotic Factors.
The Roles of HK2 on Tumorigenesis of Cervical Cancer.
Effects of resveratrol on regulation on UCP2 and cardiac function in diabetic rats.
Pterostilbene exerts a protective effect via regulating tunicamycin-induced endoplasmic reticulum stress in mouse preimplantation embryos.
Tunicamycin enhances the suppressive effects of cisplatin on lung cancer growth through PTX3 glycosylation via AKT/NF-κB signaling pathway.
Down-regulation of lncRNA OGFRP1 induces autophagy and growth inhibition by AKT/mTOR signaling pathway in HCAECs.
Allicin attenuated chronic social defeat stress induced depressive-like behaviors through suppression of NLRP3 inflammasome.
JTC-801 inhibits the proliferation and metastasis of the Hep G2 hepatoblastoma cell line by regulating the phosphatidylinositol 3-kinase/protein kinase B signalling pathway.
Ebselen protects rat hearts against myocardial ischemia-reperfusion injury.
Doxorubicin conjugated with nanodiamonds and in free form commit glioblastoma cells to heterodromous fates.
Exogenous Tetranectin Protects Against 1-Methyl-4-Phenylpyridine-Induced Neurotoxicity by Inhibiting Apoptosis and Autophagy Through Ribosomal Protein S6 Kinase Beta-1.
Trans-vaccenic acid inhibits proliferation and induces apoptosis of human nasopharyngeal carcinoma cells via a mitochondrial-mediated apoptosis pathway.
Pterostilbene alleviates hydrogen peroxide-induced oxidative stress via nuclear factor erythroid 2 like 2 pathway in mouse preimplantation embryos.
Identification of microRNAs in granulosa cells from patients with different levels of ovarian reserve function and the potential regulatory function of miR-23a in granulosa cell apoptosis.
Soft fibrin matrix downregulates DAB2IP to promote Nanog-dependent growth of colon tumor-repopulating cells.
κ-Opioid receptor stimulation reduces palmitate-induced apoptosis via Akt/eNOS signaling pathway.
Long non-coding RNA FAM84B-AS promotes resistance of gastric cancer to platinum drugs through inhibition of FAM84B expression.
Autophagic flux blockage in alveolar epithelial cells is essential in silica nanoparticle-induced pulmonary fibrosis.
Protective Effect of Koumine, an Alkaloid from Gelsemium Sempervirens, on Injury Induced by H₂O₂ in IPEC-J2 Cells.
Identification of diterpenoid compounds that interfere with Fli-1 DNA binding to suppress leukemogenesis.
Cordycepin sensitizes breast cancer cells toward irradiation through elevating ROS production involving Nrf2.
Silence of S1 RNA binding domain 1 represses cell growth and promotes apoptosis in human non-small cell lung cancer cells.
Bruceine D inhibits tumor growth and stem cell-like traits of osteosarcoma through inhibition of STAT3 signaling pathway.
Propofol Attenuates Hypoxia/Reoxygenation-Induced Apoptosis and Autophagy in HK-2 Cells by Inhibiting JNK Activation.
Protective effect of miR-20a against hypoxia/reoxygenation treatment on cardiomyocytes cell viability and cell apoptosis by targeting TLR4 and inhibiting p38 MAPK/JNK signaling.
Ginsenoside Rb1 mitigates oxidative stress and apoptosis induced by methylglyoxal in SH-SY5Y cells via the PI3K/Akt pathway.
Anti-tumour effects of red blood cell membrane-camouflaged black phosphorous quantum dots combined with chemotherapy and anti-inflammatory therapy.
Ribociclib (LEE011) suppresses cell proliferation and induces apoptosis of MDA-MB-231 by inhibiting CDK4/6-cyclin D-Rb-E2F pathway.
Molecular mechanism of miR-204 regulates proliferation, apoptosis and autophagy of cervical cancer cells by targeting ATF2.
Transarterial Infusion of iRGD-Modified ZrO(2) Nanoparticles with Lipiodol Improves the Tissue Distribution of Doxorubicin and Its Antitumor Efficacy.
Histone deacetylases inhibitor MS-275 suppresses human esophageal squamous cell carcinoma cell growth and progression via the PI3K/Akt/mTOR pathway.
Long non-coding RNA GAPLINC promotes angiogenesis by regulating miR-211 under hypoxia in human umbilical vein endothelial cells.
Effects of kojic acid on boar sperm quality and anti-bacterial activity during liquid preservation at 17 C.
HDAC5-mediated deacetylation and nuclear localisation of SOX9 is critical for tamoxifen resistance in breast cancer.
Hepatotoxicity and mechanism study of chrysophanol-8-O-glucoside in vitro.
miR-885-5p Negatively Regulates Warburg Effect by Silencing Hexokinase 2 in Liver Cancer.
Hydrogen sulfide attenuates mitochondrial dysfunction-induced cellular senescence and apoptosis in alveolar epithelial cells by upregulating sirtuin 1.
Combination of the natural compound Periplocin and TRAIL induce esophageal squamous cell carcinoma apoptosis in vitro and in vivo: Implication in anticancer therapy.
Genome-wide CRISPR screen identifies ELP5 as a determinant of gemcitabine sensitivity in gallbladder cancer.
Upregulating MicroRNA-410 or Downregulating Wnt-11 Increases Osteoblasts and Reduces Osteoclasts to Alleviate Osteonecrosis of the Femoral Head.
Protease-activated receptor 2 (PAR-2) antagonist AZ3451 as a novel therapeutic agent for osteoarthritis.
LncRNA AC007271.3 promotes cell proliferation, invasion, migration and inhibits cell apoptosis of OSCC via the Wnt/β-catenin signaling pathway.
TBX3 deficiency accelerates apoptosis in cardiomyoblasts through regulation of P21 expression.
Melatonin ameliorates cerebral ischemia/reperfusion injury through SIRT3 activation.
HMGB1/TLR4 promotes apoptosis and reduces autophagy of hippocampal neurons in diabetes combined with OSA.
Sulforaphane inhibits gastric cancer stem cells via suppressing sonic hedgehog pathway.
Melatonin promotes secondary hair follicle development of early postnatal cashmere goat and improves cashmere quantity and quality by enhancing antioxidant capacity and suppressing apoptosis.
UNBS5162 as a novel naphthalimide holds efficacy in human gastric carcinoma cell behaviors mediated by AKT/ERK signaling pathway.
Upregulation of miR‑95-3p inhibits growth of osteosarcoma by targeting HDGF.
The expression of Bcl-2 in adenomyosis and its effect on proliferation, migration, and apoptosis of endometrial stromal cells.
RING finger protein 10 is a potential drug target for diabetic vascular complications.
HSF1 phosphorylation by cyclosporin A confers hyperthermia sensitivity through suppression of HSP expression.
Galectin-3 Mediates Endothelial-to-Mesenchymal Transition in Pulmonary Arterial Hypertension.
Platelet-Membrane-Camouflaged Black Phosphorus Quantum Dots Enhance Anticancer Effect Mediated by Apoptosis and Autophagy.
[Effect of the chemoprotectant tempol on anti-tumor activity of cisplatin].
EXT1, Regulated by MiR-665, Promotes Cell Apoptosis via ERK1/2 Signaling Pathway in Acute Lymphoblastic Leukemia.
Resveratrol induces apoptosis of benign prostatic hyperplasia epithelial cell line (BPH-1) through p38 MAPK-FOXO3a pathway.
HO-1 reduces heat stress-induced apoptosis in bovine granulosa cells by suppressing oxidative stress.
Exogenous H(2)S reduces the acetylation levels of mitochondrial respiratory enzymes via regulating the NAD(+)-SIRT3 pathway in cardiac tissues of db/db mice.
SALL4 induces radioresistance in nasopharyngeal carcinoma via the ATM/Chk2/p53 pathway.
Restorative effect of modified dioscorea pills on the structure of hippocampal neurovascular unit in an animal model of chronic cerebral hypoperfusion.
Cloning of a new testis-enriched gene C4orf22 and its role in cell cycle and apoptosis in mouse spermatogenic cells.
Bax inhibitor-1 overexpression in prelimbic cortex protects rats against depression-like behavior induced by olfactory bulbectomy and reduces apoptotic and inflammatory signals.
Protective effects of ethyl gallate on H(2)O(2)-induced mitochondrial dysfunction in PC12 cells.
Luteolin attenuates glucocorticoid-induced osteoporosis by regulating ERK/Lrp-5/GSK-3β signaling pathway in vivo and in vitro.
Astragaloside IV enhances taxol chemosensitivity of breast cancer via caveolin-1-targeting oxidant damage.
Heme oxygenase 1 regulates apoptosis induced by heat stress in bovine ovarian granulosa cells via the ERK1/2 pathway.
Deficiency of TPPP2, a factor linked to oligoasthenozoospermia, causes subfertility in male mice.
Potent effects of dioscin against hepatocellular carcinoma through regulating TP53-induced glycolysis and apoptosis regulator (TIGAR)-mediated apoptosis, autophagy, and DNA damage.
Ribociclib, a selective cyclin D kinase 4/6 inhibitor, inhibits proliferation and induces apoptosis of human cervical cancer in vitro and in vivo.
Host defense peptide Hymenochirin-1B induces lung cancer cell apoptosis and cell cycle arrest through the mitochondrial pathway.
Impact of Taurine on the proliferation and apoptosis of human cervical carcinoma cells and its mechanism.
Ginsenoside Rk1 induces cell cycle arrest and apoptosis in MDA-MB-231 triple negative breast cancer cells.
Novel half-sandwich iridium OˆC (carbene)-Complexes: In vitro and in vivo tumor growth suppression and pro-apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes.
Cadmium-induced apoptosis through reactive oxygen species-mediated mitochondrial oxidative stress and the JNK signaling pathway in TM3 cells, a model of mouse Leydig cells.
The Orexin-A-Regulated Akt/mTOR Pathway Promotes Cell Proliferation Through Inhibiting Apoptosis in Pancreatic Cancer Cells.
Analysis of microRNA Expression Profiles Induced by Yiqifumai Injection in Rats with Chronic Heart Failure.
β-Sitosterol and Gemcitabine Exhibit Synergistic Anti-pancreatic Cancer Activity by Modulating Apoptosis and Inhibiting Epithelial-Mesenchymal Transition by Deactivating Akt/GSK-3β Signaling.
Protective Effects of Costunolide Against D-Galactosamine and Lipopolysaccharide-Induced Acute Liver Injury in Mice.
Add-On therapy with Chinese herb medicine Bo-Er-Ning capsule (BENC) improves outcomes of gastric cancer patients: a randomized clinical trial followed with bioinformatics-assisted mechanism study.
Targeting P-Glycoprotein: Nelfinavir Reverses Adriamycin Resistance in K562/ADR Cells.
High Concentration of Aspirin Induces Apoptosis in Rat Tendon Stem Cells via Inhibition of the Wnt/β-Catenin Pathway.
Alpha-Lipoic Acid Protects Human Aortic Endothelial Cells Against H2O2-Induced Injury and Inhibits Atherosclerosis in Ovariectomized Low Density Lipoprotein Receptor Knock-Out Mice.
HSP70/HSP90-Organizing Protein Contributes to Gastric Cancer Progression in an Autocrine Fashion and Predicts Poor Survival in Gastric Cancer.
Novel Serum Biomarkers Detected by Protein Array in Polycystic Ovary Syndrome with Low Progesterone Level.
Atorvastatin Attenuates Myocardial Hypertrophy in Spontaneously Hypertensive Rats via the C/EBPβ/PGC-1α/UCP3 Pathway.
MnTMPyP inhibits paraquat-induced pulmonary epithelial-like cell injury by inhibiting oxidative stress.
MiR-320 regulates cardiomyocyte apoptosis induced by ischemia-reperfusion injury by targeting AKIP1.
Hydrogen Sulfide Alleviates Lipopolysaccharide-Induced Diaphragm Dysfunction in Rats by Reducing Apoptosis and Inflammation through ROS/MAPK and TLR4/NF-κB Signaling Pathways.
Portulaca Extract Attenuates Development of Dextran Sulfate Sodium Induced Colitis in Mice through Activation of PPARγ.
The Protective Effects of Levo-Tetrahydropalmatine on ConA-Induced Liver Injury Are via TRAF6/JNK Signaling.
Proscillaridin A Promotes Oxidative Stress and ER Stress, Inhibits STAT3 Activation, and Induces Apoptosis in A549 Lung Adenocarcinoma Cells.
Hydrogen Sulfide Alleviates Acute Myocardial Ischemia Injury by Modulating Autophagy and Inflammation Response under Oxidative Stress.
The Hepatoprotection by Oleanolic Acid Preconditioning: Focusing on PPARα Activation.
Activating the PGC-1α/TERT Pathway by Catalpol Ameliorates Atherosclerosis via Modulating ROS Production, DNA Damage, and Telomere Function: Implications on Mitochondria and Telomere Link.
Fucosterol Protects against Concanavalin A-Induced Acute Liver Injury: Focus on P38 MAPK/NF-κB Pathway Activity.
Proscillaridin A induces apoptosis, inhibits STAT3 activation and augments doxorubicin toxicity in prostate cancer cells.
SND1 acts as an anti-apoptotic factor via regulating the expression of lncRNA UCA1 in hepatocellular carcinoma.
Notch signaling inhibitor DAPT provides protection against acute craniocerebral injury.
Codelivery of doxorubicin and MDR1-siRNA by mesoporous silica nanoparticles-polymerpolyethylenimine to improve oral squamous carcinoma treatment.
HDAC1 Silence Promotes Neuroprotective Effects of Human Umbilical Cord-Derived Mesenchymal Stem Cells in a Mouse Model of Traumatic Brain Injury via PI3K/AKT Pathway.
Realgar, a traditional Chinese medicine, induces apoptosis of HPV16-positive cervical cells through a HPV16 E7-related pathway.
XRCC1 rs1799782 (C194T) polymorphism correlated with tumor metastasis and molecular subtypes in breast cancer.
Brevilin A promotes oxidative stress and induces mitochondrial apoptosis in U87 glioblastoma cells.
Transcriptional Repression of p53 by PAX3 Contributes to Gliomagenesis and Differentiation of Glioma Stem Cells.
Combination Treatment of Icariin and L-DOPA Against 6-OHDA-Lesioned Dopamine Neurotoxicity.
Pyrroline-5-carboxylate reductase 1 promotes cell proliferation via inhibiting apoptosis in human malignant melanoma.
Therapeutic Potential of a Prolyl Hydroxylase Inhibitor FG-4592 for Parkinson's Diseases in Vitro and in Vivo: Regulation of Redox Biology and Mitochondrial Function.
ABT737 reverses cisplatin resistance by targeting glucose metabolism of human ovarian cancer cells.
Knockdown of NUPR1 inhibits the growth of U266 and RPMI8226 multiple myeloma cell lines via activating PTEN and caspase activation‑dependent apoptosis.
Interferon Gamma Inhibits CXCL8-Induced Proliferation and Migration of Pancreatic Cancer BxPC-3 Cell Line via a RhoGDI2/Rac1/NF-κB Signaling Pathway.
Activation of STAT3 and Bcl-2 and reduction of reactive oxygen species (ROS) promote radioresistance in breast cancer and overcome of radioresistance with niclosamide.
TMCO1 is essential for ovarian follicle development by regulating ER Ca(2+) store of granulosa cells.
UBIAD1 protects against oxygen-glucose deprivation/reperfusion-induced multiple subcellular organelles injury through PI3K/AKT pathway in N2A cells.
The protective effects of distal ischemic treatment on apoptosis and mitochondrial permeability in the hippocampus after cardiopulmonary resuscitation.
LncRNA TDRG1 enhances tumorigenicity in endometrial carcinoma by binding and targeting VEGF-A protein.
Overexpression of SMARCA2 or CAMK2D is associated with cisplatin resistance in human epithelial ovarian cancer.
Rapamycin Supplementation May Ameliorate Erectile Function in Rats With Streptozotocin-Induced Type 1 Diabetes by Inducing Autophagy and Inhibiting Apoptosis, Endothelial Dysfunction, and Corporal Fibrosis.
Effects of Guanfu total base on Bcl-2 and Bax expression and correlation with atrial fibrillation.
Rapid induction of apoptosis in tumor cells treated with a new platinum(II) complex based on amino-thiazolidinone.
Different sulfonylureas induce the apoptosis of proximal tubular epithelial cell differently via closing K(ATP) channel.
LP1 from Lentinula edodes C(91-3) Induces Autophagy, Apoptosis and Reduces Metastasis in Human Gastric Cancer Cell Line SGC-7901.
Tumor-targeting core-shell structured nanoparticles for drug procedural controlled release and cancer sonodynamic combined therapy.
Anti-breast-Cancer Activity Exerted by β-Sitosterol-d-glucoside from Sweet Potato via Upregulation of MicroRNA-10a and via the PI3K-Akt Signaling Pathway.
Selenoprotein S protects against adipocyte death through mediation of the IRE1α-sXBP1 pathway.
ABT-199-mediated inhibition of Bcl-2 as a potential therapeutic strategy for nasopharyngeal carcinoma.
Concurrence of autophagy with apoptosis in alveolar epithelial cells contributes to chronic pulmonary toxicity induced by methamphetamine.
Zinc enhances chemosensitivity to paclitaxel in PC‑3 prostate cancer cells.
Probiotics decrease depressive behaviors induced by constipation via activating the AKT signaling pathway.
Dual effects of baicalin on osteoclast differentiation and bone resorption.
β-Bourbonene attenuates proliferation and induces apoptosis of prostate cancer cells.
Effects of zerumbone on proliferation and apoptosis of esophageal cancer cells and on P53 and Bcl-2 expression levels.
Eugenol protects the transplanted heart against ischemia/reperfusion injury in rats by inhibiting the inflammatory response and apoptosis.
Layer-by-layer assembled gold nanoshells for the intracellular delivery of miR-34a.
Low-Dose Radiation Enhanced Inhibition of Breast Tumor Xenograft and Reduced Myocardial Injury Induced by Doxorubicin.
Newcastle disease virus V protein inhibits apoptosis in DF-1 cells by downregulating TXNL1.
Nucleus pulposus cell apoptosis is attenuated by CDMP-2 through regulating oxidative damage under the hyperosmotic environment.
Disruption of Chromosomal Architecture of cox2 Locus Sensitizes Lung Cancer Cells to Radiotherapy.
Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway.
Sestrin 2 confers primary resistance to sorafenib by simultaneously activating AKT and AMPK in hepatocellular carcinoma.
BF211, a derivative of bufalin, enhances the cytocidal effects in multiple myeloma cells by inhibiting the IL-6/JAK2/STAT3 pathway.
RNA interference of long noncoding RNA HOTAIR suppresses autophagy and promotes apoptosis and sensitivity to cisplatin in oral squamous cell carcinoma.
HMGB1 knock-down promoting tumor cells viability and arrest pro-apoptotic proteins via Stat3/NFκB in HepG2 cells.
3‑Bromopyruvate sensitizes human breast cancer cells to TRAIL‑induced apoptosis via the phosphorylated AMPK‑mediated upregulation of DR5.
Excessive apoptosis and disordered autophagy flux contribute to the neurotoxicity induced by high iodine in Sprague-Dawley rat.
Cantharidin inhibits melanoma cell proliferation via the miR‑21‑mediated PTEN pathway.
Aclidinium inhibits proliferation and metastasis of ovarian cancer SKOV3 cells via downregulating PI3K/AKT/mTOR signaling pathway.
Isoliquiritigenin inhibits cell proliferation and migration through the PI3K/AKT signaling pathway in A549 lung cancer cells.
DNMTs inhibitor SGI-1027 induces apoptosis in Huh7 human hepatocellular carcinoma cells.
UNBS5162 induces growth inhibition and apoptosis via inhibiting PI3K/AKT/mTOR pathway in triple negative breast cancer MDA-MB-231 cells.
Activation of α7 nicotinic acetylcholine receptor alleviates Aβ(1-42)-induced neurotoxicity via downregulation of p38 and JNK MAPK signaling pathways.
The relationship between lncRNA PCGEM1 and STAT3 during the occurrence and development of endometrial carcinoma.
Abnormally elevated USP37 expression in breast cancer stem cells regulates stemness, epithelial-mesenchymal transition and cisplatin sensitivity.
Chloroquine ameliorates carbon tetrachloride-induced acute liver injury in mice via the concomitant inhibition of inflammation and induction of apoptosis.
An E-selectin targeting and MMP-2-responsive dextran-curcumin polymeric prodrug for targeted therapy of acute kidney injury.
Ginsenoside Rg5 induces apoptosis and autophagy via the inhibition of the PI3K/Akt pathway against breast cancer in a mouse model.
Alisol B-23-acetate, a tetracyclic triterpenoid isolated from Alisma orientale, induces apoptosis in human lung cancer cells via the mitochondrial pathway.
Effects and mechanism of amyloid β1-42 on mitochondria in astrocytes.
Cantharidin suppresses cell growth and migration, and activates autophagy in human non-small cell lung cancer cells.
Lenalidomide improvement of cisplatin antitumor efficacy on triple-negative breast cancer cells in vitro.
Cardioprotection of CAPE-oNO(2) against myocardial ischemia/reperfusion induced ROS generation via regulating the SIRT1/eNOS/NF-κB pathway in vivo and in vitro.
After Treatment with Methylene Blue is Effective against Delayed Encephalopathy after Acute Carbon Monoxide Poisoning.
Diallyl Trisulfide inhibits breast cancer stem cells via suppression of Wnt/β-catenin pathway.
Matrine reversed multidrug resistance of breast cancer MCF-7/ADR cells through PI3K/AKT signaling pathway.
The NK1 receptor antagonist NKP608 inhibits proliferation of human colorectal cancer cells via Wnt signaling pathway.
The molecular landscape of synchronous colorectal cancer reveals genetic heterogeneity.
Betulinic acid chemosensitizes breast cancer by triggering ER stress-mediated apoptosis by directly targeting GRP78.
Procyanidin from peanut skin induces antiproliferative effect in human prostate carcinoma cells DU145.
MicroRNA-1247 inhibits cell proliferation by directly targeting ZNF346 in childhood neuroblastoma.
Neuroprotective effect of phosphocreatine on oxidative stress and mitochondrial dysfunction induced apoptosis in vitro and in vivo: Involvement of dual PI3K/Akt and Nrf2/HO-1 pathways.
PEST-containing nuclear protein mediates the proliferation, migration, and invasion of human neuroblastoma cells through MAPK and PI3K/AKT/mTOR signaling pathways.
Rat Model of Brain Injury to Occupants of Vehicles Targeted by Land Mines: Mitigation by Elastomeric Frame Designs.
Fluoride induces apoptosis via inhibiting SIRT1 activity to activate mitochondrial p53 pathway in human neuroblastoma SH-SY5Y cells.
Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice.
Donor Treatment With a Hypoxia-Inducible Factor-1 Agonist Prevents Donation After Cardiac Death Liver Graft Injury in a Rat Isolated Perfusion Model.
Bcl-2 overexpression reduces cisplatin cytotoxicity by decreasing ER-mitochondrial Ca2+ signaling in SKOV3 cells.
Capsaicin enhances the antitumor activity of sorafenib in hepatocellular carcinoma cells and mouse xenograft tumors through increased ERK signaling.
MicroRNA-124a inhibits cell proliferation and migration in liver cancer by regulating interleukin-11.
Overexpression of Nitrogen Permease Regulator Like-2 (NPRL2) Enhances Sensitivity to Irinotecan (CPT-11) in Colon Cancer Cells by Activating the DNA Damage Checkpoint Pathway.
7-Acetylsinumaximol B Induces Apoptosis and Autophagy in Human Gastric Carcinoma Cells through Mitochondria Dysfunction and Activation of the PERK/eIF2α/ATF4/CHOP Signaling Pathway.
New Drug Candidate Targeting the 4A1 Orphan Nuclear Receptor for Medullary Thyroid Cancer Therapy.
Epidermal Growth Factor, through Alleviating Oxidative Stress, Protect IPEC-J2 Cells from Lipopolysaccharides-Induced Apoptosis.
Wnt/β-catenin signaling mediates the suppressive effects of diallyl trisulfide on colorectal cancer stem cells.
Luteoloside attenuates anoxia/reoxygenation-induced cardiomyocytes injury via mitochondrial pathway mediated by 14-3-3η protein.
Osteopontin is essential for IL-1β production and apoptosis in peri-implantitis.
Cognitive-enhancing effect of polysaccharides from Flammulina velutipes on Alzheimer's disease by compatibilizing with ginsenosides.
Osthole inhibits the PI3K/AKT signaling pathway via activation of PTEN and induces cell cycle arrest and apoptosis in esophageal squamous cell carcinoma.
CD300A promotes tumor progression by PECAM1, ADCY7 and AKT pathway in acute myeloid leukemia.
Curcumin-Loaded Solid Lipid Nanoparticles Enhanced Anticancer Efficiency in Breast Cancer.
Design, synthesis and biological evaluation of N-phenyl-(2,4-dihydroxypyrimidine-5-sulfonamido)benzoyl hydrazide derivatives as thymidylate synthase (TS) inhibitors and as potential antitumor drugs.
Role of Daucosterol Linoleate on Breast Cancer: Studies on Apoptosis and Metastasis.
PGC1α promotes cisplatin resistance in human ovarian carcinoma cells through upregulation of mitochondrial biogenesis.
miRNA‑222 promotes liver cancer cell proliferation, migration and invasion and inhibits apoptosis by targeting BBC3.
Isorhamnetin: A hepatoprotective flavonoid inhibits apoptosis and autophagy via P38/PPAR-α pathway in mice.
Coptisine from Rhizoma coptidis exerts an anti-cancer effect on hepatocellular carcinoma by up-regulating miR-122.
Self-assembled RNAi nanoflowers via rolling circle transcription for aptamer-targeted siRNA delivery.
CART peptide activates the Nrf2/HO-1 antioxidant pathway and protects hippocampal neurons in a rat model of Alzheimer's disease.
Formononetin, an isoflavone from Astragalus membranaceus inhibits proliferation and metastasis of ovarian cancer cells.
Damage to the myogenic differentiation of C2C12 cells by heat stress is associated with up-regulation of several selenoproteins.
Cisplatin and curcumin co-loaded nano-liposomes for the treatment of hepatocellular carcinoma.
UNBS5162 inhibits the proliferation of human A549 non-small-cell lung cancer cells by promoting apoptosis.
Anticancer effect of SZC015 on pancreatic cancer via mitochondria-dependent apoptosis and the constitutive suppression of activated nuclear factor κB and STAT3 in vitro and in vivo.
Protective Effect of Selenoprotein X Against Oxidative Stress-Induced Cell Apoptosis in Human Hepatocyte (LO2) Cells via the p38 Pathway.
Downregulation of TRIM28 inhibits growth and increases apoptosis of nude mice with non‑small cell lung cancer xenografts.
UNBS5162 inhibits the proliferation of esophageal cancer squamous cells via the PI3K/AKT signaling pathway.
Molecular mechanisms of Ellis‑van Creveld gene variations in ventricular septal defect.
Pseudolaric acid B induced autophagy, but not apoptosis, in MRC5 human fibroblast cells.
The inhibitory effects of soybean isoflavones on testicular cell apoptosis in mice with type 2 diabetes.
Experimental evidence of good efficacy and reduced toxicity with peptide-doxorubicin to treat gastric cancer.
Increased high mobility group A 2 expression promotes transition of cervical intraepithelial neoplasm into cervical cancer.
Propranolol enhanced the anti-tumor effect of sunitinib by inhibiting proliferation and inducing G0/G1/S phase arrest in malignant melanoma.
Capsaicin prevents mitochondrial damage, protects cardiomyocytes subjected to anoxia/reoxygenation injury mediated by 14-3-3η/Bcl-2.
Vascular peroxidase 1 mediates hypoxia-induced pulmonary artery smooth muscle cell proliferation, apoptosis resistance and migration.
Quantitative proteomics analysis of the role of tetraspanin-8 in the drug resistance of gastric cancer.
TAT‑fused IP3R‑derived peptide enhances cisplatin sensitivity of ovarian cancer cells by increasing ER Ca2+ release.
6-Hydroxydopamine induces autophagic flux dysfunction by impairing transcription factor EB activation and lysosomal function in dopaminergic neurons and SH-SY5Y cells.
The environmental pollutant BDE-209 regulates NO/cGMP signaling through activation of NMDA receptors in neurons.
Propofol protects against endotoxin-induced myocardial injury by inhibiting NF-κB-mediated inflammation.
Targeting PI3K, mTOR, ERK, and Bcl-2 signaling network shows superior antileukemic activity against AML ex vivo.
Ginsenoside Rg3 sensitizes hypoxic lung cancer cells to cisplatin via blocking of NF-κB mediated epithelial-mesenchymal transition and stemness.
PUM1 promotes ovarian cancer proliferation, migration and invasion.
Synergistic neuroprotective effect of rasagiline and idebenone against retinal ischemia-reperfusion injury via the Lin28-let-7-Dicer pathway.
Lentivirus-mediated down-regulation of CK2α inhibits proliferation and induces apoptosis of malignant lymphoma and leukemia cells.
Effect of sorghum ethyl-acetate extract on benign prostatic hyperplasia induced by testosterone in Sprague-Dawley rats.
Mild Hypothermia Protects Renal Function in Ischemia-reperfusion Kidney: An Experimental Study in Mice.
Phenethyl isothiocyanate inhibits colorectal cancer stem cells by suppressing Wnt/β-catenin pathway.
Hypolipidemic, Antioxidant, and Antiapoptotic Effects of Polysaccharides Extracted from Reishi Mushroom, Ganoderma lucidum (Leysser: Fr) Karst, in Mice Fed a High-Fat Diet.
Ginsenoside Rb1 protects against spinal cord ischemia-reperfusion injury in rats by downregulating the Bax/Bcl-2 ratio and caspase-3 and p-Ask-1 levels.
MLH1 enhances the sensitivity of human endometrial carcinoma cells to cisplatin by activating the MLH1/c-Abl apoptosis signaling pathway.
Anti-tumoral potential of MDA19 in human osteosarcoma via suppressing PI3K/Akt/mTOR signaling pathway.
Crotonols A and B, two rare tigliane diterpenoid derivatives against K562 cells from Croton tiglium.
Metformin suppresses growth and adrenocorticotrophic hormone secretion in mouse pituitary corticotroph tumor AtT20 cells.
Synthesis and Discovery Novel Anti-Cancer Stem Cells Compounds Derived from the Natural Triterpenoic Acids.
Transcription Factor FOXO3a Is a Negative Regulator of Cytotoxicity of Fusarium mycotoxin in GES-1 Cells.
The tumor suppressor DLC1 inhibits cancer progression and oncogenic autophagy in hepatocellular carcinoma.
Mitochondrial cytochrome P450 (CYP) 1B1 is responsible for melatonin-induced apoptosis in neural cancer cells.
Overcoming resistance to mitochondrial apoptosis by BZML-induced mitotic catastrophe is enhanced by inhibition of autophagy in A549/Taxol cells.
Subthalamic nucleus deep brain stimulation protects neurons by activating autophagy via PP2A inactivation in a rat model of Parkinson's disease.
HuR stabilizes TFAM mRNA in an ATM/p38-dependent manner in ionizing irradiated cancer cells.
NOD2 promotes dopaminergic degeneration regulated by NADPH oxidase 2 in 6-hydroxydopamine model of Parkinson's disease.
Traditional Chinese Medicine CFF-1 induced cell growth inhibition, autophagy, and apoptosis via inhibiting EGFR-related pathways in prostate cancer.
Hydrogen sulfide attenuates myocardial fibrosis in diabetic rats through the JAK/STAT signaling pathway.
Endoplasmic Reticulum Stress Facilitates the Survival and Proliferation of Nucleus Pulposus Cells in TNF-α Stimulus by Activating Unfolded Protein Response.
CHOP induces apoptosis by affecting brain iron metabolism in rats with subarachnoid hemorrhage.
Targeting P-glycoprotein and SORCIN: Dihydromyricetin strengthens anti-proliferative efficiency of adriamycin via MAPK/ERK and Ca(2+) -mediated apoptosis pathways in MCF-7/ADR and K562/ADR.
Telmisartan inhibits NSCLC A549 cell proliferation and migration by regulating the PI3K/AKT signaling pathway.
Apatinib promotes apoptosis of the SMMC-7721 hepatocellular carcinoma cell line via the PI3K/Akt pathway.
Celecoxib enhances sensitivity to chemotherapy drugs of T-cell lymphoma.
Synergistic effect of receptor-interacting protein 140 and simvastatin on the inhibition of proliferation and survival of hepatocellular carcinoma cells.
MCUR1-Mediated Mitochondrial Calcium Signaling Facilitates Cell Survival of Hepatocellular Carcinoma via Reactive Oxygen Species-Dependent P53 Degradation.
Rapamycin Confers Neuroprotection against Colistin-Induced Oxidative Stress, Mitochondria Dysfunction, and Apoptosis through the Activation of Autophagy and mTOR/Akt/CREB Signaling Pathways.
Long Noncoding RNA LINC01234 Functions as a Competing Endogenous RNA to Regulate CBFB Expression by Sponging miR-204-5p in Gastric Cancer.
Astrocytes mediated the nootropic and neurotrophic effects of Sarsasapogenin-AA13 via upregulating brain-derived neurotrophic factor.
COX-2 mediates PM2.5-induced apoptosis and inflammation in vascular endothelial cells.
RIZ1 negatively regulates ubiquitin-conjugating enzyme E2C/UbcH10 via targeting c-Myc in meningioma.
Deletion of diacylglycerol-responsive TRPC genes attenuates diabetic nephropathy by inhibiting activation of the TGFβ1 signaling pathway.
Silencing HOXD10 by promoter region hypermethylation activates ERK signaling in hepatocellular carcinoma.
Downregulation of Mitochondrial Single Stranded DNA Binding Protein (SSBP1) Induces Mitochondrial Dysfunction and Increases the Radiosensitivity in Non-Small Cell Lung Cancer Cells.
Santamarine Inhibits NF-кB and STAT3 Activation and Induces Apoptosis in HepG2 Liver Cancer Cells via Oxidative Stress.
Endoplasmic Reticulum Stress Mediates Methamphetamine-Induced Blood-Brain Barrier Damage.
Dehydrocostus lactone, a natural sesquiterpene lactone, suppresses the biological characteristics of glioma, through inhibition of the NF-κB/COX-2 signaling pathway by targeting IKKβ.
Obatoclax and LY3009120 Efficiently Overcome Vemurafenib Resistance in Differentiated Thyroid Cancer.
Exogenous H(2)S restores ischemic post-conditioning-induced cardioprotection through inhibiting endoplasmic reticulum stress in the aged cardiomyocytes.
Osterix Decreases the Chemosensitivity of Breast Cancer Cells by Upregulating GALNT14.
β-Catenin Cooperates with CREB Binding Protein to Promote the Growth of Tumor Cells.
Propofol Through Upregulating Caveolin-3 Attenuates Post-Hypoxic Mitochondrial Damage and Cell Death in H9C2 Cardiomyocytes During Hyperglycemia.
N-Cadherin-Mediated Activation of PI3K/Akt-GSK-3β Signaling Attenuates Nucleus Pulposus Cell Apoptosis Under High-Magnitude Compression.
N-Cadherin Maintains the Healthy Biology of Nucleus Pulposus Cells under High-Magnitude Compression.
Deoxyelephantopin Induces Reactive Oxygen Species-Mediated Apoptosis and Autophagy in Human Osteosarcoma Cells.
Exogenous Hydrogen Sulfide Ameliorates Diabetes-Associated Cognitive Decline by Regulating the Mitochondria-Mediated Apoptotic Pathway and IL-23/IL-17 Expression in db/db Mice.
Baicalin Attenuates Cardiac Dysfunction and Myocardial Remodeling in a Chronic Pressure-Overload Mice Model.
Capsular Polysaccharide of Mycoplasma ovipneumoniae Induces Sheep Airway Epithelial Cell Apoptosis via ROS-Dependent JNK/P38 MAPK Pathways.
Santamarine Inhibits NF-κB Activation and Induces Mitochondrial Apoptosis in A549 Lung Adenocarcinoma Cells via Oxidative Stress.
TBHQ Alleviated Endoplasmic Reticulum Stress-Apoptosis and Oxidative Stress by PERK-Nrf2 Crosstalk in Methamphetamine-Induced Chronic Pulmonary Toxicity.
Pretreatment Donors after Circulatory Death with Simvastatin Alleviates Liver Ischemia Reperfusion Injury through a KLF2-Dependent Mechanism in Rat.
Inhibition of Caveolae Contributes to Propofol Preconditioning-Suppressed Microvesicles Release and Cell Injury by Hypoxia-Reoxygenation.
Relaxin Attenuates Contrast-Induced Human Proximal Tubular Epithelial Cell Apoptosis by Activation of the PI3K/Akt Signaling Pathway In Vitro.
Downregulation of UBC9 promotes apoptosis of activated human LX-2 hepatic stellate cells by suppressing the canonical NF-κB signaling pathway.
Curcumin potentiates the potent antitumor activity of ACNU against glioblastoma by suppressing the PI3K/AKT and NF-κB/COX-2 signaling pathways.
UNBS5162 inhibits proliferation of human retinoblastoma cells by promoting cell apoptosis.
Activation of Autophagy Contributes to Sevoflurane-Induced Neurotoxicity in Fetal Rats.
Rosiglitazone Exerts an Anti-depressive Effect in Unpredictable Chronic Mild-Stress-Induced Depressive Mice by Maintaining Essential Neuron Autophagy and Inhibiting Excessive Astrocytic Apoptosis.
Adipose-Derived Stem Cell-Derived Exosomes Ameliorate Erectile Dysfunction in a Rat Model of Type 2 Diabetes.
Puerarin increases the chemosensitivity of hepatocellular carcinoma cells.
MicroRNA-145 protects follicular granulosa cells against oxidative stress-induced apoptosis by targeting Krüppel-like factor 4.
11β-hydroxysteroid dehydrogenases-2 decreases the apoptosis of MC3T3/MLO-Y4 cells induced by glucocorticoids.
AMPK activation-dependent autophagy compromises oleanolic acid-induced cytotoxicity in human bladder cancer cells.
Pretreatment with propylene glycol alginate sodium sulfate ameliorated concanavalin A-induced liver injury by regulating the PI3K/Akt pathway in mice.
In vitro anticancer activities of osthole against renal cell carcinoma cells.
Melatonin potentiates the antitumor effect of curcumin by inhibiting IKKβ/NF-κB/COX-2 signaling pathway.
Enhanced antitumor activity in A431 cells via encapsulation of 20(R)-ginsenoside Rg3 in PLGA nanoparticles.
SIRT1 induces resistance to apoptosis in human granulosa cells by activating the ERK pathway and inhibiting NF-κB signaling with anti-inflammatory functions.
miR-15a-5p levels correlate with poor ovarian response in human follicular fluid.
Critical role of p21 on olaquindox-induced mitochondrial apoptosis and S-phase arrest involves activation of PI3K/AKT and inhibition of Nrf2/HO-1pathway.
miR-181a increases FoxO1 acetylation and promotes granulosa cell apoptosis via SIRT1 downregulation.
KIF26B, a novel oncogene, promotes proliferation and metastasis by activating the VEGF pathway in gastric cancer.
An autophagic mechanism is involved in the 6-hydroxydopamine-induced neurotoxicity in vivo.
ANP promotes proliferation and inhibits apoptosis of ovarian granulosa cells by NPRA/PGRMC1/EGFR complex and improves ovary functions of PCOS rats.
Effects of In Utero Exposure to Di-n-Butyl Phthalate on Testicular Development in Rat.
Axin1 up-regulated 1 accelerates stress-induced cardiomyocytes apoptosis through activating Wnt/β-catenin signaling.
Downregulation of NMI promotes tumor growth and predicts poor prognosis in human lung adenocarcinomas.
Mcl-1 stabilization confers resistance to taxol in human gastric cancer.
Knockdown of SLC39A7 inhibits cell growth and induces apoptosis in human colorectal cancer cells.
Berberine activates caspase-9/cytochrome c-mediated apoptosis to suppress triple-negative breast cancer cells in vitro and in vivo.
Cysteine-rich buccal gland protein suppressed the proliferation, migration and invasion of hela cells through akt pathway.
Effectively enhancing cytotoxic and apoptotic effects of alpha-momorcharin by integrating a heparin-binding peptide.
Dectin-1 is essential for IL-1β production through JNK activation and apoptosis in Aspergillus fumigatus keratitis.
Spatiotemporal Expression of Bcl-2/Bax and Neural Cell Apoptosis in the Developing Lumbosacral Spinal Cord of Rat Fetuses with Anorectal Malformations.
Combination of sonodynamic with temozolomide inhibits C6 glioma migration and promotes mitochondrial pathway apoptosis via suppressing NHE-1 expression.
PD149163 induces hypothermia to protect against brain injury in acute cerebral ischemic rats.
Correlation between miR-19a inhibition and radiosensitivity in SiHa cervical cancer cells.
The liver protection of propylene glycol alginate sodium sulfate preconditioning against ischemia reperfusion injury: focusing MAPK pathway activity.
Inhibited effects of CAPE-pNO(2) on cervical carcinoma in vivo and in vitro and its detected metabolites.
COPS5 inhibition arrests the proliferation and growth of serous ovarian cancer cells via the elevation of p27 level.
Curcumin inhibits bladder cancer stem cells by suppressing Sonic Hedgehog pathway.
Fascaplysin inhibit ovarian cancer cell proliferation and metastasis through inhibiting CDK4.
Apelin protects against myocardial ischemic injury by inhibiting dynamin-related protein 1.
Quercetin exerts synergetic anti-cancer activity with 10-hydroxy camptothecin.
Dehydrobruceine B enhances the cisplatin-induced cytotoxicity through regulation of the mitochondrial apoptotic pathway in lung cancer A549 cells.
Antioxidation, anti-inflammation and anti-apoptosis by paeonol in LPS/d-GalN-induced acute liver failure in mice.
Geniposide protects pancreatic β cells from high glucose-mediated injury by activation of AMP-activated protein kinase.
The transcription factor FOXA1 induces epithelial ovarian cancer tumorigenesis and progression.
The soy-derived peptide Vglycin inhibits the growth of colon cancer cells in vitro and in vivo.
EGCG protects against homocysteine-induced human umbilical vein endothelial cells apoptosis by modulating mitochondrial-dependent apoptotic signaling and PI3K/Akt/eNOS signaling pathways.
PCSK9 regulates apoptosis in human lung adenocarcinoma A549 cells via endoplasmic reticulum stress and mitochondrial signaling pathways.
Diosmetin exerts anti-oxidative, anti-inflammatory and anti-apoptotic effects to protect against endotoxin-induced acute hepatic failure in mice.
A covalently bound inhibitor triggers EZH2 degradation through CHIP-mediated ubiquitination.
Chromium contributes to human bronchial epithelial cell carcinogenesis by activating Gli2 and inhibiting autophagy.
rLj-RGD3 induces apoptosis via the mitochondrial-dependent pathway and inhibits adhesion, migration and invasion of human HeyA8 cells via FAK pathway.
7-O-Geranylquercetin induces apoptosis in gastric cancer cells via ROS-MAPK mediated mitochondrial signaling pathway activation.
ZNF545 suppresses human hepatocellular carcinoma growth by inhibiting NF-kB signaling.
Morroniside protects SK-N-SH human neuroblastoma cells against H2O2-induced damage.
The Anticonvulsant and Neuroprotective Effects of Oxysophocarpine on Pilocarpine-Induced Convulsions in Adult Male Mice.
miR-491-5p, mediated by Foxi1, functions as a tumor suppressor by targeting Wnt3a/β-catenin signaling in the development of gastric cancer.
Hydrogen sulfide ameliorates chronic renal failure in rats by inhibiting apoptosis and inflammation through ROS/MAPK and NF-κB signaling pathways.
Beneficial effects of Lycium barbarum polysaccharide on spermatogenesis by improving antioxidant activity and inhibiting apoptosis in streptozotocin-induced diabetic male mice.
Exogenous H(2)S regulates endoplasmic reticulum-mitochondria cross-talk to inhibit apoptotic pathways in STZ-induced type I diabetes.
Inhibition of Blood-Brain Barrier Disruption by an Apolipoprotein E-Mimetic Peptide Ameliorates Early Brain Injury in Experimental Subarachnoid Hemorrhage.
miR-19 targeting of GSK3β mediates sulforaphane suppression of lung cancer stem cells.
Cr(VI) induces cytotoxicity in vitro through activation of ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction via the PI3K/Akt signaling pathway.
Simvastatin Inhibits IL-1β-Induced Apoptosis and Extracellular Matrix Degradation by Suppressing the NF-kB and MAPK Pathways in Nucleus Pulposus Cells.
SBI0206965, a novel inhibitor of Ulk1, suppresses non-small cell lung cancer cell growth by modulating both autophagy and apoptosis pathways.
Relaxin attenuates aristolochic acid induced human tubular epithelial cell apoptosis in vitro by activation of the PI3K/Akt signaling pathway.
Nrf-2-driven long noncoding RNA ODRUL contributes to modulating silver nanoparticle-induced effects on erythroid cells.
ω-3 free fatty acids and all-trans retinoic acid synergistically induce growth inhibition of three subtypes of breast cancer cell lines.
(-)-Epigallocatechin-3-Gallate Inhibits Colorectal Cancer Stem Cells by Suppressing Wnt/β-Catenin Pathway.
The role of NLRP3 inflammasome in 5-fluorouracil resistance of oral squamous cell carcinoma.
The osteogenesis-promoting effects of alpha-lipoic acid against glucocorticoid-induced osteoporosis through the NOX4, NF-kappaB, JNK and PI3K/AKT pathways.
Polyphyllin I induces G2/M phase arrest and apoptosis in U251 human glioma cells via mitochondrial dysfunction and the JNK signaling pathway.
Bone marrow mesenchymal stem cells repair cadmium-induced rat testis injury by inhibiting mitochondrial apoptosis.
The protective effect of propofol against TNF-α-induced apoptosis was mediated via inhibiting iNOS/NO production and maintaining intracellular Ca(2+) homeostasis in mouse hippocampal HT22 cells.
Cisatracurium-induced proliferation impairment and death of colorectal cancer cells, HCT116 is mediated by p53 dependent intrinsic apoptotic pathway in vitro.
DKK3 regulates cell proliferation, apoptosis and collagen synthesis in keloid fibroblasts via TGF-β1/Smad signaling pathway.
In vitro additive antitumor effects of dimethoxycurcumin and 5-fluorouracil in colon cancer cells.
Downregulation of tyrosine threonine kinase inhibits tumor growth via G2/M arrest in human endometrioid endometrial adenocarcinoma.
Estrogen receptor-α36 is involved in icaritin induced growth inhibition of triple-negative breast cancer cells.
Sesamol attenuates oxidative stress, apoptosis and inflammation in focal cerebral ischemia/reperfusion injury.
Targeting ERK enhances the cytotoxic effect of the novel PI3K and mTOR dual inhibitor VS-5584 in preclinical models of pancreatic cancer.
Down-regulation of UBC9 increases the sensitivity of hepatocellular carcinoma to doxorubicin.
Alantolactone induces apoptosis, promotes STAT3 glutathionylation and enhances chemosensitivity of A549 lung adenocarcinoma cells to doxorubicin via oxidative stress.
PKCζ phosphorylates TRAF2 to protect against intestinal ischemia-reperfusion-induced injury.
Hypertonic saline infusion suppresses apoptosis of hippocampal cells in a rat model of cardiopulmonary resuscitation.
Mitochondria-Associated Apoptosis in Human Melanoma Cells Induced by Cardanol Monoene from Cashew Nut Shell Liquid.
The synthetic antihyperlipidemic drug potassium piperate selectively kills breast cancer cells through inhibiting G1-S-phase transition and inducing apoptosis.
Crude terpene glycoside component from Radix paeoniae rubra protects against isoproterenol-induced myocardial ischemic injury via activation of the PI3K/AKT/mTOR signaling pathway.
Inducible Bcl-2 gene RNA interference mediated by aptamer-integrated HDV ribozyme switch.
7-O-geranylquercetin-induced autophagy contributes to apoptosis via ROS generation in human non-small cell lung cancer cells.
Low-level laser therapy for beta amyloid toxicity in rat hippocampus.
Anti-inflammatory and neuroprotective effects of sanguinarine following cerebral ischemia in rats.
Targeting P-glycoprotein function, p53 and energy metabolism: Combination of metformin and 2-deoxyglucose reverses the multidrug resistance of MCF-7/Dox cells to doxorubicin.
Discovery of a novel Nrf2 inhibitor that induces apoptosis of human acute myeloid leukemia cells.
Deoxyelephantopin induces apoptosis in HepG2 cells via oxidative stress, NF-κB inhibition and mitochondrial dysfunction.
Effect of Oleracein E, a Neuroprotective Tetrahydroisoquinoline, on Rotenone-Induced Parkinson's Disease Cell and Animal Models.
Wnt/β-catenin pathway mediates (-)-Epigallocatechin-3-gallate (EGCG) inhibition of lung cancer stem cells.
Propofol enhances the cisplatin-induced apoptosis on cervical cancer cells via EGFR/JAK2/STAT3 pathway.
Inhibition of store-operated Ca(2+) entry counteracts the apoptosis of nasopharyngeal carcinoma cells induced by sodium butyrate.
Triggering of apoptosis in osteosarcoma cells by graphene/single-walled carbon nanotube hybrids via the ROS-mediated mitochondrial pathway.
The protective effects of propofol against CoCl(2)-induced HT22 cell hypoxia injury via PP2A/CAMKIIα/nNOS pathway.
Propylene Glycol Alginate Sodium Sulfate Alleviates Cerulein-Induced Acute Pancreatitis by Modulating the MEK/ERK Pathway in Mice.
Induction of autophagy by an oleanolic acid derivative, SZC017, promotes ROS-dependent apoptosis through Akt and JAK2/STAT3 signaling pathway in human lung cancer cells.
Doxepin Mitigates Noise-induced Neuronal Damage in Primary Auditory Cortex of Mice via Suppression of Acid Sphingomyelinase/Ceramide Pathway.
2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin promotes endothelial cell apoptosis through activation of EP3/p38MAPK/Bcl-2 pathway.
Hydrogen Sulphide modulating mitochondrial morphology to promote mitophagy in endothelial cells under high-glucose and high-palmitate.
The inflammatory responses in Cu-mediated elemental imbalance is associated with mitochondrial fission and intrinsic apoptosis in Gallus gallus heart.
Hyperthermia with different temperatures inhibits proliferation and promotes apoptosis through the EGFR/STAT3 pathway in C6 rat glioma cells.
Gaseous signalling molecule SO2 via Hippo‑MST pathway to improve myocardial fibrosis of diabetic rats.
Antitumor effects of baicalin on ovarian cancer cells through induction of cell apoptosis and inhibition of cell migration in vitro.
Abnormal expression levels of BMP15/Smad1 are associated with granulosa cell apoptosis in patients with polycystic ovary syndrome.
Overexpression of microRNA-1470 promotes proliferation and migration, and inhibits senescence of esophageal squamous carcinoma cells.
Effect of fraxetin on proliferation and apoptosis in breast cancer cells.
Phloretin induces apoptosis of human esophageal cancer via a mitochondria-dependent pathway.
Ouabain targets the Na(+)/K(+)-ATPase α(3) isoform to inhibit cancer cell proliferation and induce apoptosis.
Inhibition of chemotherapy-induced apoptosis of testicular cells by squid ink polysaccharide.
The regulation of NLRP3 inflammasome expression during the development of cardiac contractile dysfunction in chronic kidney disease.
Adenovirus-mediated artificial miRNA targetting fibrinogen-like protein 2 attenuates the severity of acute pancreatitis in mice.
Mesenchymal stem cell conditioned medium alleviates oxidative stress injury induced by hydrogen peroxide via regulating miR143 and its target protein in hepatocytes.
Vitamin D enhances omega-3 polyunsaturated fatty acids-induced apoptosis in breast cancer cells.
Anti-colon cancer effect of caffeic acid p-nitro-phenethyl ester in vitro and in vivo and detection of its metabolites.
mTORC1 regulates apoptosis and cell proliferation in pterygium via targeting autophagy and FGFR3.
Kaiso protects human umbilical vein endothelial cells against apoptosis by differentially regulating the expression of B-cell CLL/lymphoma 2 family members.
Resveratrol inhibits age-dependent spontaneous tumorigenesis by SIRT1-mediated post-translational modulations in the annual fish Nothobranchius guentheri.
Establishment of an ideal time window model in hypothermic-targeted temperature management after traumatic brain injury in rats.
Exogenous H(2)S facilitating ubiquitin aggregates clearance via autophagy attenuates type 2 diabetes-induced cardiomyopathy.
Epigallocatechin-3-gallate inhibits H(2)O(2)-induced apoptosis in Mouse Vascular Smooth Muscle Cells via 67kD Laminin Receptor.
Phosphocreatine protects endothelial cells from Methylglyoxal induced oxidative stress and apoptosis via the regulation of PI3K/Akt/eNOS and NF-κB pathway.
Protective effect of calretinin on testicular Leydig cells via the inhibition of apoptosis.
Protective effect of naringin against the LPS-induced apoptosis of PC12 cells: Implications for the treatment of neurodegenerative disorders.
Curcumin Suppresses Lung Cancer Stem Cells via Inhibiting Wnt/β-catenin and Sonic Hedgehog Pathways.
Sox2 inhibits Wnt-β-catenin signaling and metastatic potency of cisplatin-resistant lung adenocarcinoma cells.
Atorvastatin prevents Angiotensin II induced myocardial hypertrophy in vitro via CCAAT/enhancer-binding protein β.
Down-regulation of miR-146b-5p by long noncoding RNA MALAT1 in hepatocellular carcinoma promotes cancer growth and metastasis.
The mir-675-5p regulates the progression and development of pancreatic cancer via the UBQLN1-ZEB1-mir200 axis.
High glucose induces apoptosis via upregulation of Bim expression in proximal tubule epithelial cells.
Thiol peroxiredoxin, a novel allergen from Bombyx mori, modulates functions of macrophages and dendritic cells.
Hypoxia Promotes Gastric Cancer Malignancy Partly through the HIF-1α Dependent Transcriptional Activation of the Long Non-coding RNA GAPLINC.
Hydrogen sulfide decreases high glucose/palmitate-induced autophagy in endothelial cells by the Nrf2-ROS-AMPK signaling pathway.
Exogenous H2S contributes to recovery of ischemic post-conditioning-induced cardioprotection by decrease of ROS level via down-regulation of NF-κB and JAK2-STAT3 pathways in the aging cardiomyocytes.
Sulforaphane induces apoptosis and inhibits invasion in U251MG glioblastoma cells.
ML-7 amplifies the quinocetone-induced cell death through akt and MAPK-mediated apoptosis on HepG2 cell line.
Ghrelin Protects against Dexamethasone-Induced INS-1 Cell Apoptosis via ERK and p38MAPK Signaling.
Wnt5a Increases Properties of Lung Cancer Stem Cells and Resistance to Cisplatin through Activation of Wnt5a/PKC Signaling Pathway.
Vitamin K2 Induces Mitochondria-Related Apoptosis in Human Bladder Cancer Cells via ROS and JNK/p38 MAPK Signal Pathways.
Development of Novel Erythromycin Derivatives with Inhibitory Activity against Proliferation of Tumor Cells.
OFD1, as a Ciliary Protein, Exhibits Neuroprotective Function in Photoreceptor Degeneration Models.
Colistin-Induced Apoptosis of Neuroblastoma-2a Cells Involves the Generation of Reactive Oxygen Species, Mitochondrial Dysfunction, and Autophagy.
Effect of GADD45a on olaquindox-induced apoptosis in human hepatoma G2 cells: Involvement of mitochondrial dysfunction.
Progranulin protects against endotoxin-induced acute kidney injury by downregulating renal cell death and inflammatory responses in mice.
Propranolol sensitizes thyroid cancer cells to cytotoxic effect of vemurafenib.
Co-expression of ING4 and P53 enhances hypopharyngeal cancer chemosensitivity to cisplatin in vivo.
Berberine enhances the anti‑tumor activity of tamoxifen in drug‑sensitive MCF‑7 and drug‑resistant MCF‑7/TAM cells.
Mir143-BBC3 cascade reduces microglial survival via interplay between apoptosis and autophagy: Implications for methamphetamine-mediated neurotoxicity.
Polyphenols from hawthorn peels and fleshes differently mitigate dyslipidemia, inflammation and oxidative stress in association with modulation of liver injury in high fructose diet-fed mice.
Mycoplasma ovipneumoniae induces sheep airway epithelial cell apoptosis through an ERK signalling-mediated mitochondria pathway.
Non-benzoquinone geldanamycin analogs trigger various forms of death in human breast cancer cells.
BG-4, a novel anticancer peptide from bitter gourd (Momordica charantia), promotes apoptosis in human colon cancer cells.
3,3'-diindolylmethane mitigates total body irradiation-induced hematopoietic injury in mice.
Knockdown of USP39 induces cell cycle arrest and apoptosis in melanoma.
Effect of Polygonatum odoratum extract on human breast cancer MDA-MB-231 cell proliferation and apoptosis.
Novel recombinant protein FlaA N/C increases tumor radiosensitivity via NF-κB signaling in murine breast cancer cells.
Deep hypothermia-enhanced autophagy protects PC12 cells against oxygen glucose deprivation via a mitochondrial pathway.
Neuroprotective effects of Kaempferide-7-O-(4″-O-acetylrhamnosyl)-3-O-rutinoside on cerebral ischemia-reperfusion injury in rats.
Doxorubicin and resveratrol co-delivery nanoparticle to overcome doxorubicin resistance.
Capsaicin mediates caspases activation and induces apoptosis through P38 and JNK MAPK pathways in human renal carcinoma.
Anticancer effect of SZC015 on lung cancer cells through ROS-dependent apoptosis and autophagy induction mechanisms in vitro.
Depletion of JMJD5 sensitizes tumor cells to microtubule-destabilizing agents by altering microtubule stability.
Age-associated up-regulation of EGR1 promotes granulosa cell apoptosis during follicle atresia in mice through the NF-κB pathway.
Design, synthesis, and biological evaluation of (2E)-(2-oxo-1, 2-dihydro-3H-indol-3-ylidene)acetate derivatives as anti-proliferative agents through ROS-induced cell apoptosis.
Alpha-lipoic acid defends homocysteine-induced endoplasmic reticulum and oxidative stress in HAECs.
Triazole fungicide tebuconazole disrupts human placental trophoblast cell functions.
The p38 MAPK inhibitor BIRB796 enhances the antitumor effects of VX680 in cervical cancer.
Ginsenoside Rg3 induces FUT4-mediated apoptosis in H. pylori CagA-treated gastric cancer cells by regulating SP1 and HSF1 expressions.
β-Carotene Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cell Lines via the Cav-1/AKT/NF-κB Signaling Pathway.
Phosphocreatine protects against LPS-induced human umbilical vein endothelial cell apoptosis by regulating mitochondrial oxidative phosphorylation.
Progranulin deficiency leads to severe inflammation, lung injury and cell death in a mouse model of endotoxic shock.
Pseudolaric acid B activates autophagy in MCF-7 human breast cancer cells to prevent cell death.
Dioscin suppresses human laryngeal cancer cells growth via induction of cell-cycle arrest and MAPK-mediated mitochondrial-derived apoptosis and inhibition of tumor invasion.
miR-194 inhibits the proliferation, invasion, migration, and enhances the chemosensitivity of non-small cell lung cancer cells by targeting forkhead box A1 protein.
MiR-125a-5p decreases after long non-coding RNA HOTAIR knockdown to promote cancer cell apoptosis by releasing caspase 2.
Oleanolic acid inhibits cell survival and proliferation of prostate cancer cells in vitro and in vivo through the PI3K/Akt pathway.
Suppression of SOX18 by siRNA inhibits cell growth and invasion of breast cancer cells.
Matrigel and Activin A promote cell-cell contact and anti-apoptotic activity in cultured human retinal pigment epithelium cells.
Synergistic chemopreventive effects of curcumin and berberine on human breast cancer cells through induction of apoptosis and autophagic cell death.
Dioscin Induces Apoptosis in Human Cervical Carcinoma HeLa and SiHa Cells through ROS-Mediated DNA Damage and the Mitochondrial Signaling Pathway.
Increased mitochondrial fission promotes autophagy and hepatocellular carcinoma cell survival through the ROS-modulated coordinated regulation of the NFKB and TP53 pathways.
The E545K mutation of PIK3CA promotes gallbladder carcinoma progression through enhanced binding to EGFR.
Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation.
HDAC6 promotes cell proliferation and confers resistance to gefitinib in lung adenocarcinoma.
Berberine in combination with cisplatin suppresses breast cancer cell growth through induction of DNA breaks and caspase-3-dependent apoptosis.
Latcripin-13 domain induces apoptosis and cell cycle arrest at the G1 phase in human lung carcinoma A549 cells.
MiRNA-203 suppresses cell proliferation, migration and invasion in colorectal cancer via targeting of EIF5A2.
Preventive Effects of a Novel Polysaccharide from Sepia esculenta Ink on Ovarian Failure and Its Action Mechanisms in Cyclophosphamide-Treated Mice.
Expression and prognostic role of ubiquitination factor E4B in primary hepatocellular carcinoma.
Antitumor activity of ginseng sapogenins, 25-OH-PPD and 25-OCH3-PPD, on gastric cancer cells.
Novel Recombinant Protein FlaA N/C Protects against Radiation Injury via NF-κB Signaling.
Smac mimetic‑induced caspase‑independent necroptosis requires RIP1 in breast cancer.
Anti-tumor activity of the TRPM8 inhibitor BCTC in prostate cancer DU145 cells.
Overexpressed EDIL3 predicts poor prognosis and promotes anchorage-independent tumor growth in human pancreatic cancer.
SZC015, a synthetic oleanolic acid derivative, induces both apoptosis and autophagy in MCF-7 breast cancer cells.
Gamabufotalin, a major derivative of bufadienolide, inhibits VEGF-induced angiogenesis by suppressing VEGFR-2 signaling pathway.
ROCK inhibitor Y27632 promotes proliferation and diminishes apoptosis of marmoset induced pluripotent stem cells by suppressing expression and activity of caspase 3.
Oncogenic role of the TP53-induced glycolysis and apoptosis regulator in nasopharyngeal carcinoma through NF-κB pathway modulation.
Effects of induced pluripotent stem cells-derived conditioned medium on the proliferation and anti-apoptosis of human adipose-derived stem cells.
Anticancer effect of SZC017, a novel derivative of oleanolic acid, on human gastric cancer cells.
Tectonic 1 Is a Key Regulator of Cell Proliferation in Pancreatic Cancer.
CREB-binding protein regulates lung cancer growth by targeting MAPK and CPSF4 signaling pathway.
Polyphyllin VII induces apoptosis in HepG2 cells through ROS-mediated mitochondrial dysfunction and MAPK pathways.
Overexpression of RBM5 induces autophagy in human lung adenocarcinoma cells.
The Protective Role of the TOPK/PBK Pathway in Myocardial Ischemia/Reperfusion and H₂O₂-Induced Injury in H9C2 Cardiomyocytes.
Decreased TPD52 expression is associated with poor prognosis in primary hepatocellular carcinoma.
Apoptosis induction of dehydrobruceine B on two kinds of human lung cancer cell lines through mitochondrial-dependent pathway.
β-elemene sensitizes hepatocellular carcinoma cells to oxaliplatin by preventing oxaliplatin-induced degradation of copper transporter 1.
ABT737 reverses cisplatin resistance by regulating ER-mitochondria Ca2+ signal transduction in human ovarian cancer cells.
Naringin protects against lipopolysaccharide-induced cardiac injury in mice.
Inhibition of tissue transglutaminase promotes Aβ-induced apoptosis in SH-SY5Y cells.
Gefitinib enhances oxaliplatin-induced apoptosis mediated by Src and PKC-modulated gap junction function.
PACE4 regulates apoptosis in human pancreatic cancer Panc‑1 cells via the mitochondrial signaling pathway.
Anti-tumor effects of osthole on ovarian cancer cells in vitro.
Triptolide Combined with Radiotherapy for the Treatment of Nasopharyngeal Carcinoma via NF-κB-Related Mechanism.
VNN1 promotes atherosclerosis progression in apoE-/- mice fed a high-fat/high-cholesterol diet.
Hyperthermotherapy enhances antitumor effect of 5-aminolevulinic acid-mediated sonodynamic therapy with activation of caspase-dependent apoptotic pathway in human glioma.
Potential implications of Apolipoprotein E in early brain injury after experimental subarachnoid hemorrhage: Involvement in the modulation of blood-brain barrier integrity.
CD147 overexpression promotes tumorigenicity in Chinese hamster ovary cells.
Puerarin ameliorates cognitive deficits in streptozotocin-induced diabetic rats.
Gadd45b prevents autophagy and apoptosis against rat cerebral neuron oxygen-glucose deprivation/reperfusion injury.
Shikonin induces apoptosis of HaCaT cells via the mitochondrial, Erk and Akt pathways.
Protective effects of p-nitro caffeic acid phenethyl ester on acute myocardial ischemia-reperfusion injury in rats.
CARMA3 regulates the invasion, migration, and apoptosis of non-small cell lung cancer cells by activating NF-кB and suppressing the P38 MAPK signaling pathway.
LncRNA-UCA1 enhances cell proliferation and 5-fluorouracil resistance in colorectal cancer by inhibiting miR-204-5p.
MED27 promotes melanoma growth by targeting AKT/MAPK and NF-κB/iNOS signaling pathways.
PACE4 regulates apoptosis in human prostate cancer cells via endoplasmic reticulum stress and mitochondrial signaling pathways.
PCSK9 regulates apoptosis in human neuroglioma u251 cells via mitochondrial signaling pathways.
Level of circulated microRNA-421 in gastric carcinoma and related mechanisms.
A comparison of the biological effects of 125I seeds continuous low-dose-rate radiation and 60Co high-dose-rate gamma radiation on non-small cell lung cancer cells.
Matrine attenuates focal cerebral ischemic injury by improving antioxidant activity and inhibiting apoptosis in mice.
Alpha-Lipoic Acid Promotes Osteoblastic Formation in H2O2 -Treated MC3T3-E1 Cells and Prevents Bone Loss in Ovariectomized Rats.
Oxymatrine attenuated hypoxic-ischemic brain damage in neonatal rats via improving antioxidant enzyme activities and inhibiting cell death.
17-Demethoxy-reblastatin, an Hsp90 inhibitor, induces mitochondria-mediated apoptosis through downregulation of Mcl-1 in human hepatocellular carcinoma cells.
Cold-inducible RNA-binding protein inhibits neuron apoptosis through the suppression of mitochondrial apoptosis.
Protein kinase CK2α catalytic subunit is overexpressed and serves as an unfavorable prognostic marker in primary hepatocellular carcinoma.
BPTF promotes tumor growth and predicts poor prognosis in lung adenocarcinomas.
MicroRNA‑328 directly targets p21‑activated protein kinase 6 inhibiting prostate cancer proliferation and enhancing docetaxel sensitivity.
Pseudolaric acid B inhibits proliferation in SW579 human thyroid squamous cell carcinoma.
Quercetin reverses experimental pulmonary arterial hypertension by modulating the TrkA pathway.
Bortezomib-mediated down-regulation of telomerase and disruption of telomere homeostasis contributes to apoptosis of malignant cells.
Progranulin protects against renal ischemia/reperfusion injury in mice.
RASSF10 suppresses hepatocellular carcinoma growth by activating P53 signaling and methylation of RASSF10 is a docetaxel resistant marker.
miRNA-1207-5p is associated with cancer progression by targeting stomatin-like protein 2 in esophageal carcinoma.
Effects of ghrelin on postresuscitation brain injury in a rat model of cardiac arrest.
Pretreatment with low dose etomidate prevents etomidate-induced rat adrenal insufficiency by regulating oxidative stress-related MAPKs and apoptosis.
By reducing hexokinase 2, resveratrol induces apoptosis in HCC cells addicted to aerobic glycolysis and inhibits tumor growth in mice.
An ESRG-interacting protein, COXII, is involved in pro-apoptosis of human embryonic stem cells.
Novel taspine derivative 12k inhibits cell growth and induces apoptosis in lung cell carcinoma.
Enantioselective apoptosis induced by individual isomers of bifenthrin in Hep G2 cells.
Effect of baicalin-copper on the induction of apoptosis in human hepatoblastoma cancer HepG2 cells.
Bcl-2 phosphorylation triggers autophagy switch and reduces mitochondrial damage in limb remote ischemic conditioned rats after ischemic stroke.
A new dimeric neolignan from Magnolia grandiflora L. seeds.
Tetrachlorobenzoquinone triggers the cleavage of Bid and promotes the cross-talk of extrinsic and intrinsic apoptotic signalings in pheochromocytoma (PC) 12 cells.
Flotillin-2 promotes metastasis of nasopharyngeal carcinoma by activating NF-κB and PI3K/Akt3 signaling pathways.
Expression profile of apoptotic and proliferative proteins in hypoxic HUVEC treated with statins.
SZC017, a novel oleanolic acid derivative, induces apoptosis and autophagy in human breast cancer cells.
Phosphocreatine protects endothelial cells from oxidized low-density lipoprotein-induced apoptosis by modulating the PI3K/Akt/eNOS pathway.
O-Alkylated derivatives of quercetin induce apoptosis of MCF-7 cells via a caspase-independent mitochondrial pathway.
Optimization of intrinsic and extrinsic tendon healing through controllable water-soluble mitomycin-C release from electrospun fibers by mediating adhesion-related gene expression.
Ginsenoside Rg3 suppresses FUT4 expression through inhibiting NF-κB/p65 signaling pathway to promote melanoma cell death.
CXCR1/2 antagonism with CXCL8/Interleukin-8 analogue CXCL8(3-72)K11R/G31P restricts lung cancer growth by inhibiting tumor cell proliferation and suppressing angiogenesis.
Antifibrotic effects of luteolin on hepatic stellate cells and liver fibrosis by targeting AKT/mTOR/p70S6K and TGFβ/Smad signalling pathways.
DLC-1 induces mitochondrial apoptosis and epithelial mesenchymal transition arrest in nasopharyngeal carcinoma by targeting EGFR/Akt/NF-κB pathway.
Potent effects of dioscin against liver fibrosis.
Trichostatin A targets the mitochondrial respiratory chain, increasing mitochondrial reactive oxygen species production to trigger apoptosis in human breast cancer cells.
Lycium barbarum polysaccharide prevents focal cerebral ischemic injury by inhibiting neuronal apoptosis in mice.
Lycium barbarum polysaccharides protect human lens epithelial cells against oxidative stress-induced apoptosis and senescence.
PNMA1 promotes cell growth in human pancreatic ductal adenocarcinoma.
mTOR inhibitor AZD8055 inhibits proliferation and induces apoptosis in laryngeal carcinoma.
The proapoptotic effect of formononetin in human osteosarcoma cells: involvement of inactivation of ERK and Akt pathways.
14-Thienyl methylene matrine (YYJ18), the derivative from matrine, induces apoptosis of human nasopharyngeal carcinoma cells by targeting MAPK and PI3K/Akt pathways in vitro.
Naringin inhibits TNF-α induced oxidative stress and inflammatory response in HUVECs via Nox4/NF-κ B and PI3K/Akt pathways.
The mitochondrial thioredoxin is required for liver development in zebrafish.
Dioscin attenuates hepatic ischemia-reperfusion injury in rats through inhibition of oxidative-nitrative stress, inflammation and apoptosis.
Galectin-3 is associated with a poor prognosis in primary hepatocellular carcinoma.
Tetrachloro-p-benzoquinone induces hepatic oxidative damage and inflammatory response, but not apoptosis in mouse: the prevention of curcumin.
miR-203a regulates proliferation, migration, and apoptosis by targeting glycogen synthase kinase-3β in human renal cell carcinoma.
Endoplasmic reticulum stress is involved in restraint stress-induced hippocampal apoptosis and cognitive impairments in rats.
Chemical characterization and antitumor activities of polysaccharide extracted from Ganoderma lucidum.
Interplay between the Notch and PI3K/Akt pathways in high glucose-induced podocyte apoptosis.
Dioscin-induced apoptosis of human LNCaP prostate carcinoma cells through activation of caspase-3 and modulation of Bcl-2 protein family.
Ubiquitin‑specific protease 22‑induced autophagy is correlated with poor prognosis of pancreatic cancer.
Galangin inhibits growth of human head and neck squamous carcinoma cells in vitro and in vivo.
Potentiation of paclitaxel activity by curcumin in human breast cancer cell by modulating apoptosis and inhibiting EGFR signaling.
MicroRNA-206 overexpression promotes apoptosis, induces cell cycle arrest and inhibits the migration of human hepatocellular carcinoma HepG2 cells.
Potent effects of flavonoid-rich extract from Rosa laevigata Michx fruit against hydrogen peroxide-induced damage in PC12 cells via attenuation of oxidative stress, inflammation and apoptosis.
Puerarin protected the brain from cerebral ischemia injury via astrocyte apoptosis inhibition.
Sine oculis homeobox homolog 1 promotes α5β1-mediated invasive migration and metastasis of cervical cancer cells.
Dioscin promotes osteoblastic proliferation and differentiation via Lrp5 and ER pathway in mouse and human osteoblast-like cell lines.
Anti-cancer effects of dioscin on three kinds of human lung cancer cell lines through inducing DNA damage and activating mitochondrial signal pathway.
The protective effect of Cold-inducible RNA-binding protein (CIRP) on testicular torsion/detorsion: an experimental study in mice.
Administration of cathepsin B inhibitor CA-074Me reduces inflammation and apoptosis in polymyositis.
Protective effect of flavonoid-rich extract from Rosa laevigata Michx on cerebral ischemia-reperfusion injury through suppression of apoptosis and inflammation.
PPARγ mediates the effects of WIN55,212-2, an synthetic cannabinoid, on the proliferation and apoptosis of the BEL-7402 hepatocarcinoma cells.
Oxysophoridine protects against focal cerebral ischemic injury by inhibiting oxidative stress and apoptosis in mice.
Synergistic anti-glioma effect of Hydroxygenkwanin and Apigenin in vitro.
Notch pathway is involved in high glucose-induced apoptosis in podocytes via Bcl-2 and p53 pathways.
Hepatitis B viral RNA directly mediates down-regulation of the tumor suppressor microRNA miR-15a/miR-16-1 in hepatocytes.
Notch1 signaling contributes to the oncogenic effect of HBx on human hepatic cells.
Cathepsin L stimulates autophagy and inhibits apoptosis of ox-LDL-induced endothelial cells: potential role in atherosclerosis.
Emodin regulates apoptotic pathway in human liver cancer cells.
Chemical composition of total flavonoids from Salvia chinensia Benth and their pro-apoptotic effect on hepatocellular carcinoma cells: potential roles of suppressing cellular NF-κB signaling.
Protective effects of the total saponins from Rosa laevigata Michx fruit against carbon tetrachloride-induced acute liver injury in mice.
Expression and role of grainyhead-like 2 in gastric cancer.
Neuroprotective effect of Danshensu derivatives as anti-ischaemia agents on SH-SY5Y cells and rat brain.
The synthesis and biological evaluation of novel Danshensu-cysteine analog conjugates as cardiovascular-protective agents.
Alantolactone induces activation of apoptosis in human hepatoma cells.
Total flavonoids from Rosa Laevigata Michx fruit attenuates hydrogen peroxide induced injury in human umbilical vein endothelial cells.
Nestin protects mouse podocytes against high glucose-induced apoptosis by a Cdk5-dependent mechanism.
Autophagy-related gene 7 (ATG7) and reactive oxygen species/extracellular signal-regulated kinase regulate tetrandrine-induced autophagy in human hepatocellular carcinoma.
Role of mitochondrial pathway in compression-induced apoptosis of nucleus pulposus cells.
Activation of apoptosis by ethyl acetate fraction of ethanol extract of Dianthus superbus in HepG2 cell line.
Putative tumor suppressor miR-145 inhibits colon cancer cell growth by targeting oncogene Friend leukemia virus integration 1 gene.
NF-κB, JNK and p53 pathways are involved in tubeimoside-1-induced apoptosis in HepG2 cells with oxidative stress and G₂/M cell cycle arrest.
Enantioselective cytotoxicity of isocarbophos is mediated by oxidative stress-induced JNK activation in human hepatocytes.
alpha-Bisabolol induces dose- and time-dependent apoptosis in HepG2 cells via a Fas- and mitochondrial-related pathway, involves p53 and NFkappaB.
Chen J, Zhang Q, Huang J, He H, Bai Y, An Y, Hao M, Zhao W, Li W, Feng S, Yang S, Liao J, Wong YK, Dai L, Du Q, Luo P, Wang J
International journal of biological sciences 2026;22(1):481-499
International journal of biological sciences 2026;22(1):481-499
Hsa_circ_0000313/miR-1224-3p/MKNK2 Axis Modulates CD4(+) T Cells by Activating p38 MAPK Signaling in Myasthenia Gravis.
Li Y, Kong X, Cai H, Tian W, Ren Y, Xu F, Peng S, Niu J, Xin G, Wang J, Zhang H, Wang L
Mediators of inflammation 2026;2026(1):e2877539
Mediators of inflammation 2026;2026(1):e2877539
Targeting Pulmonary Hypertension: Elucidating Sophocarpine's Protective Role via Preclinical Models.
Xie F, Feng J, Li K, Chen Y, Han L, Wu Y
Mediators of inflammation 2026;2026:5524066
Mediators of inflammation 2026;2026:5524066
Epithelial Gab1 Restricts Sepsis-Induced Intestinal Injury by Orchestrating TNF/NF-κB Axis.
Jin W, Wu Y, Cheng X, Pan Y, He L, Xu Y, Xu J, Zhang X
Mediators of inflammation 2026;2026:5486971
Mediators of inflammation 2026;2026:5486971
A cyclometalated iridium(III) complex induces paraptotic cell death via mitochondrial dysfunction and ER stress in triple-negative breast cancer cells.
Lin H, Wei J, Yao W, Zhang Q, Jin J
Frontiers in pharmacology 2026;17:1739226
Frontiers in pharmacology 2026;17:1739226
Prognostic significance of calcium signaling-related genes in bladder cancer and the role of ATP2B4 in regulating mitochondrial calcium ion levels via the VDAC1/MCU pathway.
Zhang L, Gong Y, Chen J, Li M, Wang X, Wang W, Ding Q, Li Y
Frontiers in immunology 2026;17:1561666
Frontiers in immunology 2026;17:1561666
The brain imaging feature-related gene NRP2 drives the malignant progression of glioblastoma through the FAK pathway: a Mendelian randomization study.
Li Y, Que J, Xia Y, Wang L, Zhang P, Cheng Z, Gao B
Translational oncology 2026 May;67:102732
Translational oncology 2026 May;67:102732
PLOD2 Promotes Cutaneous Squamous Cell Carcinoma Progression in Association With STAT3-Related ERK and AKT Pathways.
Xian N, Wang Z, Wang B, Wang X, Zheng Y
Molecular carcinogenesis 2026 May;65(5):615-629
Molecular carcinogenesis 2026 May;65(5):615-629
miR-329-3p derived from mast cells-exosomes exacerbates intestinal ischemia-reperfusion injury by targeting ATG10 to regulate autophagy.
Liang Y, Sheng R, Deng H, Huang D, Xu K, Wang Y, Liu D
International journal of biological macromolecules 2026 May;361:152091
International journal of biological macromolecules 2026 May;361:152091
Seminal plasma extracellular vesicle-derived miR-296-3p targets PLA2G6 to enhance boar sperm motility by lowering Lys Phosphatidylcholine.
Zhao K, An Y, Zhang Y, Zhang J, Li H, Wang J, Yao Z, Wang T, Chen L, Chen X, Jin Y
Animal reproduction science 2026 May;288:108135
Animal reproduction science 2026 May;288:108135
Exosomes derived from Bcl-2-engineered iPSC-cardiomyocytes mitigate aortic valve calcification and inhibit cardiomyocyte apoptosis.
Li N, Xiao R, Zhu L, Cai L, Zhang Z, Sun L, Shi H, Ye H, Shao G, Gao J
International journal of pharmaceutics 2026 May 20;697:126877
International journal of pharmaceutics 2026 May 20;697:126877
Febrifugine dihydrochloride restricts porcine epidemic diarrhea virus replication by modulating the IGF1R-driven PI3K/AKT-apoptosis axis.
Yan P, Kyaw ZO, Wang X, Li N, Xu Y, Gao S, Huan C
Journal of virology 2026 May 19;100(5):e0011726
Journal of virology 2026 May 19;100(5):e0011726
Eriodictyol mitigates polystyrene nanoplastic-induced ovarian toxicity via targeted inhibition of the TLR4/NF-κB/NLRP3 inflammatory axis.
Hu N, Gao Y, Fan R, Xue Y, Fang S, Wu S, Luo T, Hu L, Zhang D, Zheng L
Environmental pollution (Barking, Essex : 1987) 2026 May 15;397:128007
Environmental pollution (Barking, Essex : 1987) 2026 May 15;397:128007
Prenylterphenyllin, a regulator of P53, inhibits colorectal cancer progression through oxidative stress and energy metabolism pathway.
Zhang Y, Han Y, Li S, Shan R, Lin L, Gu Z, Wang R, Chen Y, Xiao J, An F, Hu C, He C
Redox biology 2026 Mar;90:103993
Redox biology 2026 Mar;90:103993
Development and characterization of endolysosomal trafficking targeting chimera degraders of α(1A)-adrenergic receptor.
Chen J, Wang S, Li T, Li W, Ke X, Ma Z, Du L, Li M
Journal of advanced research 2026 Mar;81:1005-1021
Journal of advanced research 2026 Mar;81:1005-1021
Senolytic elimination of therapy-induced senescent cells by ABT-263 improves chemotherapeutic efficacy in esophageal squamous cell carcinoma.
Zhang D, Zhu J, Zou R, Zhang H, Yu BP, Li P, Luo Y, Jiang Z, Hou Y, Zhang JW
Biochemical pharmacology 2026 Mar;245:117659
Biochemical pharmacology 2026 Mar;245:117659
Ubiquitin-specific peptidase 40 promotes cellular proliferation and inhibits apoptosis through deubiquitination-mediated stabilization of c-MYC in acute myeloid leukemia.
Fu W, Wu Q, Yao Y, Sun Y, Wang H, Jie J, Zheng X, Wang L, Hu X, Tong X, Xu Q
Biochimica et biophysica acta. Molecular basis of disease 2026 Mar;1872(3):168138
Biochimica et biophysica acta. Molecular basis of disease 2026 Mar;1872(3):168138
A triple combination strategy for nasopharyngeal carcinoma: Aptamer-guided liposomal chemotherapy, engineered NK cells, and Fc-enhanced PD-L1 antibody therapy.
Yao C, Wang L, Liu W, Shi N, Liao Z, Fu Y, Ouyang J, Lei X, Huang Q, Li S, Zhouyang Y, Zhao P, Wang J, Xu H, Zhou W, Jiang X, Gao X, Ren C, Luo L
Acta pharmaceutica Sinica. B 2026 Mar;16(3):1584-1604
Acta pharmaceutica Sinica. B 2026 Mar;16(3):1584-1604
AURKA Activates FOXO3a to Form a Positive Feedback Loop in the Proliferation and Migration of Keloid Fibroblasts.
Chu X, Sun J, Dai S, Liang Y, Qian X, Xu J, Zhang J
Advances in wound care 2026 Mar;15(3):168-180
Advances in wound care 2026 Mar;15(3):168-180
Albiflorin Relieves Intervertebral Disc Degeneration Through Inhibiting Nucleus Pulposus Cell via the p38 MAPK/NF-κB Pathway.
Yang K, Cheng Y, Yang D
Immunity, inflammation and disease 2026 Mar;14(3):e70360
Immunity, inflammation and disease 2026 Mar;14(3):e70360
DUSP4 mitigates doxorubicin-induced cardiotoxicity via the p38 MAPK/MK2 signaling pathway.
Deng L, Zha Y, Zhu C, Li Y, He M, Zhang S
Biochimica et biophysica acta. Molecular cell research 2026 Mar 29;1873(5):120141
Biochimica et biophysica acta. Molecular cell research 2026 Mar 29;1873(5):120141
Acid Ceramidase Inhibition Disrupts Ceramide Homeostasis and Induces Mitochondrial Apoptosis in IDH1-Mutant Oligodendroglioma.
Larion M, Muley H, Zaibaq F, Zhang M, Davis D, Kruhlak M, Mathur S, Lita A, Song H, Zhang W, Wong Z, Harmon T, Zhang L, Cam-El Makranz C, Li A, Karadimov G, Lang F, Herold-Mende C, Yang C, Dowdy T
Research square 2026 Mar 25;
Research square 2026 Mar 25;
DIDS modulates VDAC1 oligomerization to suppress intrinsic apoptosis and attenuates in vitro and in vivo RSV infection.
Lin S, Chen X, Luo M, Cui X, Dai Y, Sun Z, Wang G, Peng H, Ling P, Long J, Zhou H, Luo C, Qi Y-F, Zhang K, Luo Y-S
Journal of virology 2026 Mar 24;100(3):e0220025
Journal of virology 2026 Mar 24;100(3):e0220025
Dual targeting of PI3Kδ and PPARα enhances antitumor activity via FoxO1 activation in follicular lymphoma.
Wang W, Zhou H, Tan S, Qin D, Wang S, Xu C, Lei X, Li W, Wang L, Fu S, Jia S, Xu B, Zha J
Cell death & disease 2026 Mar 23;17(1)
Cell death & disease 2026 Mar 23;17(1)
Biomimetic Nanoplatform for Targeted Glioblastoma Therapy via Concurrently Triggering GPX4/DHODH Mediated Ferroptosis.
Ren G, Wang X, Li P, Wu H, Bi Z, Gao Q, Ma B, Tian Z, Liu J, Feng F, Liu W, Li L, Zhang C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar 23;:e21236
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar 23;:e21236
PEAR1/EAF1 deficiency impairs aspirin responsiveness in atherosclerotic endothelium: A novel mechanism of atypical aspirin resistance.
Liu J, Peng J, Zhan Y, Liu L, Xu K, Xie Y
Microvascular research 2026 Mar 23;:104946
Microvascular research 2026 Mar 23;:104946
NRF2 Drives Aggressiveness and Chemoresistance in Ovarian Cancer Stem-like Cells.
Chang YH, Wang KH, Ding DC
International journal of molecular sciences 2026 Mar 20;27(6)
International journal of molecular sciences 2026 Mar 20;27(6)
FBXO3-mediated DUSP9 ubiquitination promotes leukemia stem cell maintenance and tyrosine kinase inhibitor resistance in chronic myeloid leukemia.
Li X, Zuo S, Zhang Y, Liu Z, Shen N, Ma Q, Sun M, Zhang B, Li M, Huang H, Gao M, Huang Z, Zhao H, Chen Y, Gao F, Fan W, Zhang Z, Hu Y, An Y, Li S, Liu M, Liu Y, Liu Y, Li C, Zhang Y, Li Y, Cao W, Wang F, Song Y, Xu L, Bian Z, Li W
Cell reports. Medicine 2026 Mar 17;7(3):102686
Cell reports. Medicine 2026 Mar 17;7(3):102686
Study on the effects and mechanisms of M2 macrophages on PYCR1-promoted biological behavior of hepatocellular carcinoma cells.
Jin X, Hou Y, Guo J, Zhang J, Wu W
Scientific reports 2026 Mar 16;16(1)
Scientific reports 2026 Mar 16;16(1)
Glycolytic metabolic reprogramming and mitochondrial dysfunction: A novel mechanism underlying PAEs-promoted cartilage inflammatory phenotype.
Liu L, Chen Y, Lin W, Zheng M, Yu T, Chen R, Yang Y, Jiao L, Ruan Q, Sun J
Ecotoxicology and environmental safety 2026 Mar 15;313:120027
Ecotoxicology and environmental safety 2026 Mar 15;313:120027
circKANSL1 promotes immature porcine Sertoli cell growth via recruiting the Vimentin to enhance its parental gene KANSL1 expression.
Yan S, Weng B, Xiang J, Chen B, Ran M
Theriogenology 2026 Mar 1;252:117772
Theriogenology 2026 Mar 1;252:117772
RRP9 suppresses hepatocellular carcinoma progression by inhibiting the PI3K/AKT/mTOR pathway.
Fu Z, Li M, Dong K, Feng J, Wang W
International journal of oncology 2026 Jun;68(6)
International journal of oncology 2026 Jun;68(6)
Leveraging ANXA1 to enhance recombinant protein yields in CHO cells: A UPR-Mediated bioprocessing approach.
Zhao Q, Zhang HJ, Han MM, Abiti J, Dong YJ, Wang JN, Lu JT, Wang W, Zhang X, Geng SL, Qiu LL, Wang XY, Hua ZC, Wang TY, Jia YL
Synthetic and systems biotechnology 2026 Jun;12:197-208
Synthetic and systems biotechnology 2026 Jun;12:197-208
Therapeutic mechanism of Changyong Decoction in suppressing colorectal cancer progression and inducing ferroptosis via the PIEZO1-PI3K/AKT signaling axis.
Han M, Shi S, Guan Z, Ma W, Wang X, Jiang H, Man S
Tissue & cell 2026 Jun;100:103379
Tissue & cell 2026 Jun;100:103379
Exploring the molecular mechanism of Shenling baizhu formula in the treatment of ulcerative colitis via the cGMP-PKG signaling pathway.
Chen J, Chen Y, Zheng H, Ding T, Xiang Y, Zhou X, Wang W, Li J, Li Z, Peng C, Fu Q, Li T, Fu Y
Journal of ethnopharmacology 2026 Jun 12;364:121498
Journal of ethnopharmacology 2026 Jun 12;364:121498
Mitochondria-targeting iridium(III) complex enhances anticancer activity via PDK inhibition and energy metabolism disruption.
Xu S, Xu N, Fang H, Zhu Z, Su Y, Su Z
Journal of inorganic biochemistry 2026 Jul;280:113317
Journal of inorganic biochemistry 2026 Jul;280:113317
Inhibition of endothelial ALOX12 mitigates cerebral ischemia-reperfusion injury by suppressing 12-HETE.
Wang T, Zhang J, Lu G, Han D, Mi T, Ma X, Wang L, He Z, Niu J
Free radical biology & medicine 2026 Jul;250:134-152
Free radical biology & medicine 2026 Jul;250:134-152
Primase subunit 2 regulates the proliferation and apoptosis of gastric cancer cells via MCM7/CDK4 and Bax/Bcl-2 pathways.
Liu B, Wang X, Wang Y, Zhang T, Guo R, Chen X, Zhang Z
Biochimica et biophysica acta. General subjects 2026 Jul;1870(7):130947
Biochimica et biophysica acta. General subjects 2026 Jul;1870(7):130947
The function and molecular mechanism of HIF-1α interacted with p-STAT3 in promoting G6PD overexpression in chronic myelogenous leukemia cells.
Ni Y, Wang L, Li Y, Duan Y, Shao H, Dong Y, Zhang J, Xu Z, Yuan L, Dou Y, Bai Z, Cui K, Teng Z, Shahzad A, Liu W, Yang Z, Zhang Q
Cellular signalling 2026 Jul;143:112451
Cellular signalling 2026 Jul;143:112451
CMTM6 promotes synovial proliferation and macrophage polarization by preventing ubiquitination of TAK1 in rheumatoid arthritis.
Luo X, Xu L, Cai J, Ma S, Song H, Yang P, Yang C
Journal of orthopaedic translation 2026 Jan;56:101005
Journal of orthopaedic translation 2026 Jan;56:101005
Lopinavir/ritonavir induces hepatotoxicity in HepG2 cells through inhibition of the Nrf2 pathway, resulting in oxidative stress, endoplasmic reticulum stress, and cell cycle arrest.
Zhou W, Dan Wang, Tu J, Li J, Xu J, Tan W, Mo D, Liang P, Guo Y, Hu M, Ye L
Toxicology letters 2026 Jan;415:111798
Toxicology letters 2026 Jan;415:111798
Narirutin Reprograms Fatty Acid Metabolism and Inhibits Tumorigenesis via Downregulating ADORA3 Expression in Colorectal Cancer.
Wang H, Jiang R, Liu C, Chen F
Journal of gastroenterology and hepatology 2026 Jan;41(1):202-214
Journal of gastroenterology and hepatology 2026 Jan;41(1):202-214
Transcriptomic analysis identifies CXCL12 as a novel candidate gene for litter size in rabbits.
Bao Z, Yang J, Li J, Cai J, Zhai P, Zhao P, Zhao B, Chen Y, Wu X
Animal bioscience 2026 Jan;39(1):240640
Animal bioscience 2026 Jan;39(1):240640
Neutrophil/Leukemia-Tropic Dual-Drug Nanomedicine Potentiates the Treatment of Acute Myeloid Leukemia.
Yue S, Zhai Z, An J, Sun H, Li J, Zhao C, Xu Y, Zhong Z
Advanced materials (Deerfield Beach, Fla.) 2026 Jan;38(6):e12635
Advanced materials (Deerfield Beach, Fla.) 2026 Jan;38(6):e12635
TRIM32 promotes anoikis resistance and metastasis in NSCLC by degrading CHEK2 to enhance IL-6 secretion.
Xu J, Liu W, Chen L, Zhang J, Zhang D, Huang X, Zhang G
Cell death and differentiation 2026 Jan;33(1):126-139
Cell death and differentiation 2026 Jan;33(1):126-139
IMPDH2 facilitates CD4+ T cell activation through AKT/mTOR pathway by upregulating SRPK1 in myasthenia gravis.
Ren Y, Wu T, Liu Z, Li L, Li Y, Xin G, Peng S, Niu J, Chen B, Cai H, Tian Q, Wang L, Zhang H
Clinical immunology (Orlando, Fla.) 2026 Jan;282:110634
Clinical immunology (Orlando, Fla.) 2026 Jan;282:110634
Hesperadin sensitizes gastric cancer cells to cisplatin via NOX1-dependent oxidative stress.
Zhu W, Li Q, Ji Z, Wu D, Chen J, Zhao Y, Wu H
Biomedical reports 2026 Jan;24(1):3
Biomedical reports 2026 Jan;24(1):3
Sesamin exerts protective effects against diquat-induced acute kidney injury by inhibiting oxidative stress, apoptosis and autophagy: A key role for the SIRT5/FOXO3a signaling pathway.
Han S, Pu Y, Liu Z
Pesticide biochemistry and physiology 2026 Jan;216(Pt 1):106728
Pesticide biochemistry and physiology 2026 Jan;216(Pt 1):106728
Mechanism of Brucella pathogenesis mediated by outer membrane protein Omp19: Synergistic activation of cytokine storm and dual apoptotic pathways.
Wei X, Xu X, Zhang S, Guo H, Zhao Y, Cui Y, Wu B, Zhao S, Liang G, Chen Z, Liu G, Tang Y, Diao Y
Microbial pathogenesis 2026 Jan;210:108125
Microbial pathogenesis 2026 Jan;210:108125
The α5-nAChR/GINS4 axis contributed to nicotine-promoted lung adenocarcinoma progression.
Wang Z, Cai J, Yang M, Yang S, Wang J, Jia Y, Sun H, Ma X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2026 Jan;207:115828
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2026 Jan;207:115828
Unraveling the role of host kinase PIM1 in Toxoplasma gondii infection: Implications for therapies.
Pan L, Zhang F, Yang Y, Sun Y, Song L, Zhang F, Zhu J, Wang Y, Wang C, Luo Q, Zhang W, Yu L, Cao Y
PLoS neglected tropical diseases 2026 Jan;20(1):e0013915
PLoS neglected tropical diseases 2026 Jan;20(1):e0013915
Carnosic Acid Mediates Production of Reactive Oxygen Species to Regulate Mitogen-Activated Protein Kinase Pathway Phosphorylation and Induce Apoptosis in Human Breast Cancer Cells.
Wang X, Xu P, Luan S, Jiao Y, Gao Y, Zhao C, Fu P
Cancer medicine 2026 Jan;15(1):e71446
Cancer medicine 2026 Jan;15(1):e71446
Paeoniflorin Ameliorates Spinal Cord Injury by Controlling Apoptosis and Ferroptosis in H(2)O(2)-Damaged PC12 Cells.
Zhang Z, Zhou Z, Zhang P, Huo Y
Immunity, inflammation and disease 2026 Jan;14(1):e70324
Immunity, inflammation and disease 2026 Jan;14(1):e70324
A pH-Responsive Biomimetic Antioxidant Nanoplatform with Dual Renal Targeting for Synergistic Therapy of Acute Kidney Injury.
Zhang S, Xie Y, Zhang L, Qi Y, Liao Q, Xu C, Yang S, Zhou H, Tan Q, Qi S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(5):e15664
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(5):e15664
Identifying C1orf122 as a potential HCC exacerbated biomarker dependently of SRPK1 regulates PI3K/AKT/GSK3β signaling pathway.
Cai J, Rong L, Wang R, Zhang Z, Sun H, Chen J, Weng D, Li X, Feng X, Lin P, Xu S, Jiang Z, Xie Y, Zhou Q
Genes & diseases 2026 Jan;13(1):101721
Genes & diseases 2026 Jan;13(1):101721
HSP90AA1 restrains clear cell renal cell carcinoma progression by promoting CADM1 expression and suppressing the PI3K-AKT pathway through interaction with FBXO7.
Yang W, Li Y, Li Z, Jiang C, Deng X, Peng D
Cell death discovery 2026 Jan 8;12(1):6
Cell death discovery 2026 Jan 8;12(1):6
Cucurbitacin B Inhibits Hepatocellular Carcinoma by Inducing Ferroptosis and Activating the cGAS-STING Pathway.
Zhang H, Chang A, Xu X, Peng H, Zhang K, Yang J, Li W, Wang X, Wang W, Yin X, Qu C, Dong X, Ni J
Current issues in molecular biology 2026 Jan 27;48(2)
Current issues in molecular biology 2026 Jan 27;48(2)
SULT1E1 exerts a protective role in COPD by inhibiting the AKT pathway: an in vivo and in vitro study.
Song W, Zhang W, Wang F, Pang S, Zhou J, Li X
Scientific reports 2026 Jan 26;16(1):6238
Scientific reports 2026 Jan 26;16(1):6238
NUSAP1 Drives Endometrial Carcinoma via IP3R Phosphorylation, Calcium Dyshomeostasis, and ER-Stress-Mediated Apoptosis.
Xiao H, Wang H, Yang H, Li F, Ma L, Ma H
ACS omega 2026 Jan 20;11(2):2499-2512
ACS omega 2026 Jan 20;11(2):2499-2512
MMSA-1 is regulated by Wnt/TCF4 and involved in multiple myeloma progression and invasion via RAS/RAF signaling pathway.
Meng S, Liu H, Gu L, Wang J, Wang J, Zhao W
Annals of hematology 2026 Jan 15;105(1):11
Annals of hematology 2026 Jan 15;105(1):11
Asiatic acid reverses cisplatin resistance in A549/DDP cells by activating the P38 MAPK/Slug pathway.
Yu M, Zhang Q, Shang W, Wei S, Wen H, Huo S, Li X, Li X, Zhang H, Tian Y
Tissue & cell 2026 Feb;98:103145
Tissue & cell 2026 Feb;98:103145
Saikosaponin D overcomes gemcitabine resistance in pancreatic cancer via AKT/mTOR pathway inhibition and synergistic induction of apoptosis and autophagy.
Zheng R, Liu Y, Zhou S, Liu G, Liu X, Yang Y, Zhang Y
Oncology reports 2026 Feb;55(2)
Oncology reports 2026 Feb;55(2)
Inhibition of primary ciliogenesis enhances efficacy of EGFR‑TKIs against non‑small cell lung cancer cells.
Jin L, Wei L, Hua J, Zhang R, Chen J, He J, Yang Y
Oncology reports 2026 Feb;55(2)
Oncology reports 2026 Feb;55(2)
USP3 stabilizes MIC19 by deubiquitination under hypoxic stress and promotes the progression of non-small cell lung cancer.
Zhao WH, Huang H, Ding C, Zhao ZX, Jia CY, Wang YJ, Hu ZX, Wang GN, Li YW, Liu JH, Liu HY, Chen J
Acta pharmacologica Sinica 2026 Feb;47(2):391-403
Acta pharmacologica Sinica 2026 Feb;47(2):391-403
A novel biomimetic nanozyme orchestrates ulcerative colitis resolution by targeting KEAP1-NRF2-ARE pathway: Redox balance restoration, colonic barrier repair, immune homeostasis regulation.
Gong P, Wang Y, Qiu JH, Li G, Chen KW, Li Z, Wang X, Wang L
Materials today. Bio 2026 Feb;36:102627
Materials today. Bio 2026 Feb;36:102627
FGF2 Enhances MSCs Secretome Therapy for Skin Photoaging by Delaying Senescence via iNAMPT/AMPK Signaling and Facilitating eNAMPT-Mediated Regenerative Crosstalk.
Zhang Y, Lu M, Ouyang J, Liang L, Li F, Pei Z, Chen L, Ye M, Tan J, Xiang L, Kong L, Huang L, Fu L, Wang W, Qin L, Zhang Z, Du J
Stem cell reviews and reports 2026 Feb;22(2):941-962
Stem cell reviews and reports 2026 Feb;22(2):941-962
OCIAD2-IQGAP1 interaction promotes pancreatic cancer progression by suppressing oxidative stress and mitochondria-mediated apoptosis.
Pan Z, Kong L, Shi F, Ying K, Xie H, Wu X, Lin G, Yao J, Chen Z, Wang Y, Chen G, Zhu Q
Cellular signalling 2026 Feb;138:112217
Cellular signalling 2026 Feb;138:112217
AI-Driven Acceleration of Fluorescence Probe Discovery.
Jiang X, Li Y, Tian X, Yang S, Luo R, Zhou C, Liu Y, Hu J, Feng S, Gan L, Ran C, Yu KH, Zhao J, Han X, Zhai X, Jia Y, Dai J, Wang X, Zhu B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(10):e15604
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(10):e15604
A trifluoromethyl quinoline derivative targets SGK1 and modulates the PI3K/AKT pathway to inhibit prostate cancer progression.
Yang X, Wang R, Xu G, Yang Z, Yao X, Liu G, Yu J, Xu B, Luo H, Cao Y
Medical oncology (Northwood, London, England) 2026 Feb 7;43(3):146
Medical oncology (Northwood, London, England) 2026 Feb 7;43(3):146
Magnesium silicate nanosheets enable sustained hydrogen release to attenuate secondary brain injury following intracerebral hemorrhage.
Ma CS, Han B, Guo JR, Guo JF, Shi CK, Liu YX, Yi WJ, Zhang LY, Deng AJ, Wang YS, He MT
Journal of translational medicine 2026 Feb 7;24(1)
Journal of translational medicine 2026 Feb 7;24(1)
Cardiac PTN-SIRT1 axis alleviates oxidative stress and promotes mitochondrial energy reprogramming to mitigate doxorubicin-induced cardiotoxicity through AMPK/PGC1α signaling.
Sun Y, Wei T, Xu H, Li H, Zhou C, Liu X, Li Y, Huang S, Zhang Q, Duan X
Acta biochimica et biophysica Sinica 2026 Feb 5;58(2):421-436
Acta biochimica et biophysica Sinica 2026 Feb 5;58(2):421-436
Bioinformatic analysis and cellular functional assays uncover the role of NXPH4 in breast cancer.
Yang DD, Xue ZK, Jia SQ, Liu CH, Yang R, Chen CL, Huang YZ, Zhao XC, Huang GL, Hou JX
Discover oncology 2026 Feb 5;17(1)
Discover oncology 2026 Feb 5;17(1)
Lidocaine potentiates thermal ablation in cholangiocarcinoma by modulating TRPV6-Driven Ca(2+)/PI3K/AKT/HSF-1 signaling pathway.
Chen PP, Lin YK, Xia MX, Feng HB, Pan YF, Tan YX, Xu MY, Xing XH, Yao XM, Hu B, Wang HY, Qin WH, Dong LW
Cancer letters 2026 Feb 28;639:218226
Cancer letters 2026 Feb 28;639:218226
Cepharanthine alleviated chronic prostatitis/chronic pelvic pain syndrome by activating Nrf2 and inhibiting the NF-κB pathway.
Zhang H, Zhang D, Wang Z, Liu K, Xu C, Sun H, Yan Z, Li C, Lu B, Yin Y, Zhao C, Niu Y, Li W
Biology direct 2026 Feb 26;21(1)
Biology direct 2026 Feb 26;21(1)
FBXO22 targets ubiquitination and degradation of c-Cbl in leukemia.
Li J, Ma L, Wang J, Xu W, Cheng Y, Zhang J, Cao H, Wang Y, Wang Z, Xu H, Li Y, Zhang Y
Scientific reports 2026 Feb 26;16(1)
Scientific reports 2026 Feb 26;16(1)
Activated Rac1 promotes chondrocyte apoptosis through the NF-κB pathway in lumbar facet joint osteoarthritis.
Wang X, Xue P, Zhang J, Jin H, Jiang J, Xu G, Cui Z
Journal of molecular histology 2026 Feb 25;57(2)
Journal of molecular histology 2026 Feb 25;57(2)
A stimuli-responsive mitochondria-targeted nanoplatform for glioblastoma therapy: modulating the blood-brain barrier and delivering precise chemotherapy.
Luo W, Zhang F, Wang K, Liu J, Chen W, Min Z, Chen X, Wu T, Yang Z, Wen L
Journal of nanobiotechnology 2026 Feb 21;24(1)
Journal of nanobiotechnology 2026 Feb 21;24(1)
DNMT3b promotes proliferation and invasion by mediating HOPX DNA methylation in lung cancer.
Guan K, Zhao S, Zhang G, Wang Y, Song D, Ding Y
iScience 2026 Feb 20;29(2):114347
iScience 2026 Feb 20;29(2):114347
Curcumin-loaded silk fibroin scaffold promotes cartilage regeneration by inhibiting angiogenesis via Drp1/ROS-mediated mitochondrial regulation.
Zhao Z, Fu J, Han J, Pan Y, Xue B, Sun X, Ma Y, Li B, Chen K, Li Z, Liang Z, Zhou X, Guo Y, Tu P
Journal of biological engineering 2026 Feb 2;20(1)
Journal of biological engineering 2026 Feb 2;20(1)
A human patient-derived organoid biobank to model tumor heterogeneity and therapeutic vulnerability for oral squamous cell carcinoma.
Wang Y, Diao P, Lv P, Qi N, Wang Z, Yan E, Li J, Wang Y, Wang D, Wu Y, Cheng J
Cell reports. Medicine 2026 Feb 17;7(2):102622
Cell reports. Medicine 2026 Feb 17;7(2):102622
A Novel Pyrazole Pyrimidine Derivative MBP346 Induces Cell Death via ROS-Mediated Mitochondrial Damage in Human Head and Neck Squamous Cell Carcinoma.
Hu C, Xu P, Hu J, Fang B, Meng J, Tang Y
Molecules (Basel, Switzerland) 2026 Feb 17;31(4)
Molecules (Basel, Switzerland) 2026 Feb 17;31(4)
Growth differentiation factor 15 promotes the malignant progression of multiple myeloma via activation of PI3K/Akt/NF-κB signaling pathway.
Fan H, Wu Y, Peng Y, Wang L, Tu S, Peng H, Yang J, Li X, Shi Z, Li M, Song K
Journal of translational medicine 2026 Feb 17;24(1)
Journal of translational medicine 2026 Feb 17;24(1)
CircRNA-TMEM71 Inhibits Human Aortic Smooth Muscle Cell Ferroptosis and Prevents Aortic Dissection Formation Through IGF2BP3-Mediated Stability of FSP1.
Zhu L, He C, Shi H, Shao G, Sun L
Journal of the American Heart Association 2026 Feb 17;15(4):e043108
Journal of the American Heart Association 2026 Feb 17;15(4):e043108
S100A10 promotes glycolysis and malignant progression of CCA by activating the HK2/ERK signaling pathway.
Wang Y, Chen W, Liu W, Zhang X, Wang Y, Dai N
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2026 Feb 17;
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2026 Feb 17;
AFP confers the resistance of lenvatinib in hepatocellular carcinoma by activating PI3K/AKT/LDHA signaling axis.
Xing W, Wang F, Feng S, Li X, Zhou Y, Wu H, Lin B, Dong X, Li M, Zhu M
Discover oncology 2026 Feb 16;17(1)
Discover oncology 2026 Feb 16;17(1)
Hijacking the Hydrogen Sulfide Axis: A Novel 4-Trifluoromethylquinoline Derivative Suppresses Glioblastoma via Cystathionine γ-Lyase Suppression.
Luo Z, Xu G, Li C, Sun Z, Chen H, Yang M, Ye Y, Chen Q, Xu B, Luo H, Sun B
Journal of medicinal chemistry 2026 Feb 12;69(3):3457-3476
Journal of medicinal chemistry 2026 Feb 12;69(3):3457-3476
14-3-3β knockdown inhibits migration and colony formation of esophageal squamous cell carcinoma cells and is associated with weakened p-AKT signaling.
Hu QH, Zhu MQ, Chen K, Huang JS, Tao Q, Guo ZB
Hereditas 2026 Feb 11;163(1)
Hereditas 2026 Feb 11;163(1)
T-cell apoptosis is more susceptible to overactivated neutrophils delivered-NETs-MPO/NE complex.
Lu C, Shao L, Li H, Gao X, Mei Y, Sun B
International immunopharmacology 2026 Feb 1;170:116100
International immunopharmacology 2026 Feb 1;170:116100
DNA Methylation-Regulated FAM107A Affects Colorectal Carcinogenesis by Inhibiting FOXM1.
Liu Y, Sun J, Shi Y, Wang L, Zhang X, Chen L
Journal of investigative surgery : the official journal of the Academy of Surgical Research 2026 Dec;39(1):2633933
Journal of investigative surgery : the official journal of the Academy of Surgical Research 2026 Dec;39(1):2633933
RFRP-3 suppresses ovarian granulosa cell function in Tan sheep via dual signaling pathways: PI3K/AKT/mTOR and MAPK/ERK1/2.
Wei S, Dai T, Song W, Ma Y, Dan X
Theriogenology 2026 Aug;260:117909
Theriogenology 2026 Aug;260:117909
Intermittent theta-burst stimulation promotes neurovascular unit remodeling after ischemic stroke in a mouse model.
Zhang J, Ding M, Luo L, Huang D, Li S, Chen S, Fan Y, Liu L, Xie H, Liu G, Yu K, Wu J, Xiao X, Wu Y
Neural regeneration research 2026 Aug 1;21(8):3598-3608
Neural regeneration research 2026 Aug 1;21(8):3598-3608
Maintaining a balanced Bcl-2/Bax ratio and increased antioxidant capacity in tissue and mitochondria inhibits apoptosis in goose fatty liver.
Zhao M, Qi R, Lv M, Sun Q, Deng M, Ge J, Geng T, Gong D
British poultry science 2026 Apr;67(2):169-178
British poultry science 2026 Apr;67(2):169-178
NSUN3-Mediated ROS Accumulation Promotes Hepatocellular Carcinoma Proliferation and Activates PI3K/AKT Pathway.
Liu H, Liang S, Peng C, Yang J, Yang Z, Mo W
Biochemical genetics 2026 Apr;64(2):2782-2796
Biochemical genetics 2026 Apr;64(2):2782-2796
Nanomagnetic Hyperthermia Sensitizes Gemcitabine Chemosensitivity in Pancreatic Cancer by Inhibiting HSPB1 to Amplify ACSL4-Mediated Ferroptosis.
Ren J, Wu S, Su T, Li H, Ding J, Chen F, Mo J, Li J, Wang Z, Han L, Wu Z
Small (Weinheim an der Bergstrasse, Germany) 2026 Apr;22(22):e14973
Small (Weinheim an der Bergstrasse, Germany) 2026 Apr;22(22):e14973
Co-exposure to polystyrene nanoplastics and hexachlorocyclohexane induces enhanced human sperm toxicity in vitro.
Liu P, Wang D, Zeng Y, Wang H, Wan F, Wu J, Huang Y, Zeng L, Yan L
Reproductive toxicology (Elmsford, N.Y.) 2026 Apr;141:109201
Reproductive toxicology (Elmsford, N.Y.) 2026 Apr;141:109201
GATA6 inhibits the periodontitis progression through regulating the Notch signaling pathway.
Li WW, Li QW, Yu J, Sui XN, Wang MM, Yin NN, Liu X
Odontology 2026 Apr;114(2):893-902
Odontology 2026 Apr;114(2):893-902
Antitumor Cytisine-Platinum(IV) Prodrugs Potentiate Crosstalk between Endoplasmic Reticulum and Mitochondria through Calcium Overload Accompanied by Immunogenic Cell Death.
Sang RX, Wang YQ, Wu XY, Li Z, Liu XM, Xie CZ, Qiao X, Feng YK, Xu JY
Journal of medicinal chemistry 2026 Apr 9;69(7):8148-8167
Journal of medicinal chemistry 2026 Apr 9;69(7):8148-8167
MiR-93-5p Loaded Lipid Nanoparticles Break the Dry Eye Vicious Cycle via Targeting MAP3K8.
Xu B, Ji X, Li L, Zhu L, Wang L, Kang J, Yang S, Fan T
ACS applied materials & interfaces 2026 Apr 8;18(13):18740-18754
ACS applied materials & interfaces 2026 Apr 8;18(13):18740-18754
Discovery of indolinone-based covalent ULK1 inhibitors that suppressed autophagy and induced apoptosis against colorectal carcinoma.
Ye J, Wang D, Pang H, Liu Q, Pan Z, Wang L, Liu B, He G
European journal of medicinal chemistry 2026 Apr 5;307:118633
European journal of medicinal chemistry 2026 Apr 5;307:118633
Selective Radioprotection by the Fusion Antioxidant Enzyme GS1XR Via an MMP-2/9-Cleavable Cell-Penetrating Switch.
He H, Chu J, Lin L, Lu L, Li C, Han Y, Pan J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Apr 30;40(8):e71768
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Apr 30;40(8):e71768
Triple-Targeted Peptide-Photosensitizer-Drug Conjugate Enables NIR-II Imaging-Guided Multimodal Therapy Against Osteosarcoma.
He X, Liang X, Yu J, Rong J, Hu J, Xu C, Cai Z, Chen J, Zhang Y, Pu X, Sun P, Wu H, Sun B
ACS nano 2026 Apr 28;20(16):12577-12595
ACS nano 2026 Apr 28;20(16):12577-12595
Cancer-Associated Fibroblast-Derived Sphingosine-1-Phosphate Activates a MALL-SDC4 Axis to Facilitate Perineural Invasion in Pancreatic Cancer.
Peng W, Cao M, Huang H, Bai S, Liu L, Liang J, Cui H, Zhou Q, Chen S, Jiang J, Liu L, Luan Z, Chen W, Xiong S, Wang R, Cheng B, Zhao Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr 22;:e75426
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr 22;:e75426
KLOTHO Deficiency Drives Ovarian Aging by Inducing Granulosa Cell Senescence and Dysfunction.
Du W, Liu A, Li H, Ma X, Yang Y
Reproductive sciences (Thousand Oaks, Calif.) 2026 Apr 17;
Reproductive sciences (Thousand Oaks, Calif.) 2026 Apr 17;
Aberrant expression of TRIM26 suppresses ferroptosis through regulating GPX4 protein stability in colorectal cancer.
Wu G, Zheng K, Xu S, Wang J, Xu J
Molecular biology reports 2026 Apr 16;53(1)
Molecular biology reports 2026 Apr 16;53(1)
Methylation of tenascin XB mediated by methyltransferase-like 3 can effectively suppress neural injury and cellular apoptosis induced by ischemic stroke.
Ding L, Feng X, Gao F
The International journal of neuroscience 2026 Apr 15;:1-13
The International journal of neuroscience 2026 Apr 15;:1-13
Phenethyl Isothiocyanate Suppresses Hepatocellular Carcinoma Progression and Immune Evasion via ZNF652 Regulation of PD-L1.
Ren D, Wu J, Zhu J, Xie C, Zhong C, Cao H, Han H, Zhu J
Phytotherapy research : PTR 2026 Apr 15;
Phytotherapy research : PTR 2026 Apr 15;
Recombinant tissue plasminogen activator protects neurons after intracerebral hemorrhage through activating the PI3K/AKT/mTOR pathway.
Jing J, Chen S, Wu X, Yang J, Liu X, Wang J, Wang J, Li Y, Zhang P, Tang Z
Neural regeneration research 2026 Apr 1;21(4):1574-1585
Neural regeneration research 2026 Apr 1;21(4):1574-1585
Inhibition of mitochondrial RNA polymerase sensitizes cancer cells to radiation by inhibiting mitochondrial respiration.
Tsunoda S, Osawa Y, Hosoya N
Journal of radiation research 2026 Apr 1;
Journal of radiation research 2026 Apr 1;
FR429 from Polygonum capitatum Demonstrates Potential as an Anti-hepatic Injury Agent by Modulating PI3K/Akt Signaling Pathway.
Yang Y, He L, He M, Zhang X, Liao S, Zeng Z, Lin Y, Tu B
Biological & pharmaceutical bulletin 2025;48(4):372-382
Biological & pharmaceutical bulletin 2025;48(4):372-382
Terpinen-4-ol suppresses proliferation and motility of cutaneous squamous cell carcinoma cells by enhancing calpain-2 expression.
Rong D, Su Y, Zeng Z, Yang Y, Lu H, Cao YU
Oncology research 2025;33(3):605-616
Oncology research 2025;33(3):605-616
Effect of anemoside B4 on ameliorating cerebral ischemic/reperfusion injury.
Fei H, Huang X
Iranian journal of basic medical sciences 2025;28(1):49-55
Iranian journal of basic medical sciences 2025;28(1):49-55
Transcriptional enhanced associate domain factor 1 regulates cortactin-binding protein 2 N-terminal-like to control cell apoptosis in thyroid cancer.
Ma Q, Zhang L, Jiang S, Zhao W
CytoJournal 2025;22:74
CytoJournal 2025;22:74
Ailanthone inhibits bladder cancer tumor and cell proliferation, epithelial-mesenchymal transition, and activation of the Janus kinase/signal transducer and activator of transcription 3 signaling pathway.
Li J, Lv Y, Xue S, Li W, Zhang X
CytoJournal 2025;22:16
CytoJournal 2025;22:16
BCLAF1 Regulates Osteoarthritic Cartilage Degradation Through Interaction with LAMTOR2.
Li S, Luo D, Liang Y, Zou Y, Pu H, Zheng M, Wang Y, Sun X, Zhu H, Zhu Y, Zhao L, Xiao J
International journal of biological sciences 2025;21(4):1666-1685
International journal of biological sciences 2025;21(4):1666-1685
Expression Profile of Urinary Exosomal miRNAs in Patients With Diabetic Kidney Disease and Their Association With Kidney Damage.
Li J, Han L, Wang T, Yang L, Zhou H
International journal of endocrinology 2025;2025:9927320
International journal of endocrinology 2025;2025:9927320
SphK1 Suppresses Human Dental Pulp Stem Cell Apoptosis by Promoting Glycolysis Under Simulated Microgravity.
Che J, Qiu Z, Hou H, Li Y, He L, Sun J, Zhang S, Li M, Pan S, Zhang W, Niu Y
Journal of tissue engineering and regenerative medicine 2025;2025:6659059
Journal of tissue engineering and regenerative medicine 2025;2025:6659059
Caffeine Alleviates Oxidative Damage of Retinal Pigment Epithelium Cells.
Liu H, Zhang W, Xiong Y, Yang M, Long H, Gong C, Li S
Journal of ophthalmology 2025;2025:6121757
Journal of ophthalmology 2025;2025:6121757
TRIM6 affects the prognosis of acute myeloid leukemia through the PI3K/AKT signaling pathway and is associated with immune infiltration.
Zhang J, Zhou W, Liu Y, Hu C, Wang S, Xu J, Wei S
PloS one 2025;20(9):e0329560
PloS one 2025;20(9):e0329560
Altered Bcl-2/Caspase signaling and hypoxia-induced apoptosis in primary human aniridia limbal stromal cells, in CoCl2 mediated hypoxic stress, in vitro.
Liu S, Li S, Hsu SL, Fries FN, Li Z, Kundu S, Seitz B, Amini M, Suiwal S, Zimmermann J, Trusen S, Stachon T, Szentmáry N
PloS one 2025;20(7):e0328157
PloS one 2025;20(7):e0328157
PPARγ inhibitors enhance the efficacy of statin therapy for steroid-induced osteonecrosis of the femoral head by directly inhibiting apoptosis and indirectly modulating lipoprotein subfractions.
Chen KY, Li XH, Chen D, Qian SD, Mei RH, Li Q, Yu XF, He XJ
PloS one 2025;20(6):e0325190
PloS one 2025;20(6):e0325190
Downregulation of OIP5-AS1 inhibits apoptosis in myocardial ischemia/reperfusion injury via modulating the MiR-145-5p/ROCK1 axis.
Yang J, Liu J, Liu X, Xu D, Zhang J
PloS one 2025;20(5):e0324909
PloS one 2025;20(5):e0324909
High SRD5A3 expression is correlated with promotion of proliferation and inhibition of apoptosis in B-cell non-Hodgkin lymphoma and suggests a poor prognosis.
Wei S, Sun J, Wen J, Yu J, Xuan Y, Huang J, Yang J, Zhang J
PloS one 2025;20(5):e0323965
PloS one 2025;20(5):e0323965
Antioxidative and anticancer effects of Tacca chantrieri extract enhancing cisplatin sensitivity in cholangiocarcinoma cells.
Armartmuntree N, Kittirat Y, Promraksa B, Loilome W, Dokduang H, Techasen A, Sansomchai P, Thanee M, O'Connor T, Kongthitilerd P, Padthaisong S
PloS one 2025;20(1):e0317111
PloS one 2025;20(1):e0317111
Lathyrol affects the expression of AR and PSA and inhibits the malignant behavior of RCC cells.
Song S, Tai L, Zhou L, Jiang J, Zhao J
Open medicine (Warsaw, Poland) 2025;20(1):20241136
Open medicine (Warsaw, Poland) 2025;20(1):20241136
Polyallylamine Hydrochloride-Modified Bovine Serum Albumin Nanoparticles Loaded with α-Solanine for Chemotherapy of Pancreatic Cancer.
Wen Z, Luo S, Liu J, Huang Y, Chen G, Cai H
International journal of nanomedicine 2025;20:4235-4255
International journal of nanomedicine 2025;20:4235-4255
Hypericin Nanoparticles-Associated Photodynamic Therapy Modulates the Biological Behavior of Hepatocellular Carcinoma by SERPINE1.
Yan X, Fan J, Qin W, Liao M, Li S, Suo L, Xie Y, Jiang X, Zou D, Liao W
International journal of nanomedicine 2025;20:3713-3730
International journal of nanomedicine 2025;20:3713-3730
Hepatic Stellate Cell TM4SF1 Accelerates Hepatic Fibrosis Progression via Interacting With the Tyrosine Kinase c-Src.
Liu S, Tan P, Chen J, Huang Z, Ren B, Jiang Z, Gu B, Yu W, Sun L, Chen Y, Ruan J, Fu W
Cellular and molecular gastroenterology and hepatology 2025;19(10):101559
Cellular and molecular gastroenterology and hepatology 2025;19(10):101559
MFAP4 Deficiency Attenuates Liver Fibrosis by Regulating Hepatic Stellate Cell Fate Through Inhibition of the FAK/PI3K/NFκB Signaling Pathway.
Liu L, Li B, Zhang Y, Nie Y, Zhang W, Chen P, Huang C, Zhu X
Cellular and molecular gastroenterology and hepatology 2025;19(10):101548
Cellular and molecular gastroenterology and hepatology 2025;19(10):101548
RET Inhibitor SPP86 Triggers Apoptosis and Activates the DNA Damage Response Through the Suppression of Autophagy and the PI3K/AKT Signaling Pathway in Melanoma Cells.
Zhang Y, Liu H, Wang K, Zheng J, Luan H, Xin M
Drug design, development and therapy 2025;19:67-82
Drug design, development and therapy 2025;19:67-82
Network Pharmacology, Molecular Docking, and in vitro Experiments Reveal the Role and Mechanism of Tanshinone IIA in Colorectal Cancer Treatment Through the PI3K/AKT Pathway.
Sun J, Qi X, Yang C, Wang S, Jiang J, Wang L, Song J, Yu B, Sun M
Drug design, development and therapy 2025;19:2959-2977
Drug design, development and therapy 2025;19:2959-2977
Blockade of the Notch Pathway by Inhibition of Fucosylation Ameliorates Chondrocyte Inflammation and Extracellular Matrix Degradation.
Zhang Y, Liu M, Wang X, Li N, Chang X, Xu J, Tian F, Wen X, Liu C, Li Y
Journal of inflammation research 2025;18:11317-11334
Journal of inflammation research 2025;18:11317-11334
Lasalocid inhibits melanoma by down-regulating FOXM1 through PI3K/AKT and JNK/P38 MAPK pathways.
Yuan Q, Jiang H, Zhu M, Chu Y, Zhang Y, Bie J, Li L
Journal of Cancer 2025;16(3):765-783
Journal of Cancer 2025;16(3):765-783
Longikaurin A, a natural ent-kaurane, suppresses proliferation, invasion and tumorigenicity in oral squamous cell carcinoma cell by via inhibiting PI3K/Akt pathway in vitro and in vivo.
Luo Y, Wang Z, Li Y, Zhang L
Journal of Cancer 2025;16(3):708-719
Journal of Cancer 2025;16(3):708-719
Cardamonin induces apoptosis of colorectal cancer cells via targeted inhibition of the JAK/STAT3/epithelial-mesenchymal transition (EMT) signaling axis.
Wu M, Chen C, Ren D, Du Z, Liu Z, Liu W
Frontiers in pharmacology 2025;16:1739201
Frontiers in pharmacology 2025;16:1739201
Efferocytosis-associated genes serve as prognostic biomarkers for pancreatic ductal adenocarcinoma and identify P2RY6 as a therapeutic target.
Wang X, Wang W, Yang C, Wang P, Liu Y, Yu L, Zhang S, Yan X, Wang J
Frontiers in immunology 2025;16:1708441
Frontiers in immunology 2025;16:1708441
Association of genetically instrumented HMGCR inhibition with the therapeutic role of prostate cancer: a Mendelian randomization study and supporting in vitro experiments.
Hao X, Mu J
Frontiers in pharmacology 2025;16:1701869
Frontiers in pharmacology 2025;16:1701869
Unveiling the novel value of TREM1 in the proneural-mesenchymal transition of glioma via tumor-associated macrophages.
Zhang C, Hu B, Wang C, Hou S, Lin N
Frontiers in immunology 2025;16:1662351
Frontiers in immunology 2025;16:1662351
Machine learning integration with multi-omics data constructs a robust prognostic model and identifies PTGES3 as a therapeutic target for precision oncology in lung adenocarcinoma.
Ruan LJ, Weng KQ, Zhang WY, Zhuang YN, Li J, Lin LM, Chen YT, Zeng YM
Frontiers in immunology 2025;16:1651270
Frontiers in immunology 2025;16:1651270
Chrysin sensitizes glioblastoma cells and spheroids to temozolomide treatment by reducing EMT and stemness phenotypes, as well as targeting multidrug resistance proteins.
Aksüt Y, Şengelen A, Gürsoy DM, Öğütcü İ, Kuvet Ö, Pekmez M
Frontiers in pharmacology 2025;16:1643186
Frontiers in pharmacology 2025;16:1643186
Analyzing the potential targets and mechanisms of liver damage induced by acetyl tributyl citrate plasticizer using network toxicology, molecular docking and in vitro experiments.
Guo DQ, Fang YM, Sun ZD, Zeng YF, Wang GD, Liang JW
Frontiers in pharmacology 2025;16:1636576
Frontiers in pharmacology 2025;16:1636576
Ailanthone induces apoptosis in U-2OS cells through the endoplasmic reticulum stress.
Zhang Y, Wu T, Li C, Luo N, Wang J, Li J, Tian M, Liu L, Li R, Zhang J
Frontiers in immunology 2025;16:1633643
Frontiers in immunology 2025;16:1633643
The function of CD164 in breast cancer and its possibility as a molecular biomarker: bioinformatics analysis and experimental validation.
Li M, Mao J, Wang G, Chen J, Hong J, Wang X, Liang B, Song D
Frontiers in immunology 2025;16:1601547
Frontiers in immunology 2025;16:1601547
IGF-1 secreted by mesenchymal stem cells affects the function of lymphatic endothelial progenitor cells: a potential strategy for the treatment of lymphedema.
Xue Z, Yang D, Jin Z, Li Y, Yu Y, Zhao X, Huang Y, Jia S, Zhang T, Huang G, Hou J
Frontiers in genetics 2025;16:1584095
Frontiers in genetics 2025;16:1584095
Targeting the BAG2/CHIP axis promotes gastric cancer apoptosis by blocking apoptosome assembly.
Liu Q, Chen Q, Wei H, Tang B, Tian B, Ma Z, Gu Q, Su X, Dong Y, Shi W, Luo C
Frontiers in immunology 2025;16:1578416
Frontiers in immunology 2025;16:1578416
Androgen receptor inhibitor ameliorates pulmonary arterial hypertension by enhancing the apoptosis level through suppressing the Notch3/Hes5 pathway.
Sun J, Lin J, Yin D, Pan Z, Ye Y, Wang Y, Wang X, Guo Q
Frontiers in pharmacology 2025;16:1572489
Frontiers in pharmacology 2025;16:1572489
Congrong Shujing Granules ameliorates mitochondrial associated membranes to against MPP(+)-induced neurological damage in the cellular model of Parkinson's disease.
Zhang C, Huang P, Cheng H, Yuan X, Zhou M, Liu Y, Liu T, Chen D, Xu Q, Cai J
Frontiers in pharmacology 2025;16:1509317
Frontiers in pharmacology 2025;16:1509317
Genipin attenuates oxidative damage in periodontal tissues by alleviating mitochondrial dysfunction and abnormal glucose uptake through inhibition of UCP2.
Deng Y, Fu R, Shang Y, Hu M, Xin X, Hou Y, Yu W, Liu X
Frontiers in pharmacology 2025;16:1446574
Frontiers in pharmacology 2025;16:1446574
Cyclic mechanical stretching enhances mitophagy and oxidative stress resistance in adipose-derived stem cells via the Piezo1/ATP axis to accelerate wound healing.
Xiao Y, Shi Z, Yuan Y, Yao D, Feng R, Zhang Y, Zhao D, Zhang H, Sun P, Liu Y, Li Y, Shen X, Wang Z, Hu D, Guan H, Wang H
Theranostics 2025;15(18):9862-9884
Theranostics 2025;15(18):9862-9884
Oxidative stress-mediated PANoptosis and ferroptosis: Exploration of multimodal cell death triggered by an AIE-active nano-photosensitizer via photodynamic therapy.
Wang Y, Chai C, Lin W, Cao J, Li Z, Jin Y, Xu Y, Zhang J, Qu Y, Zhan J, Zhao T, Chen Y, Gao M, Huang C, Li M
Theranostics 2025;15(14):6665-6685
Theranostics 2025;15(14):6665-6685
Mechanism of active component β-sitosterol from Myristica fragrans inducing apoptosis in bladder cancer cells via regulating the BCL-2/BAX/caspase-3 pathway.
Zhu Y, Tang Z, Lu Z, Gao D, Pan H, Jiang H, Zhang Z, Zhang H
Frontiers in oncology 2025;15:1698721
Frontiers in oncology 2025;15:1698721
CMSP suppresses oral squamous cell carcinoma progression by targeting the JAK2/STAT3/c-Myc axis.
Lu Y, Yao M, Wang D, Higuchi D, Lu H, Shang H, Dong B, Zhang J, Jin R, Liu T
Frontiers in oncology 2025;15:1671797
Frontiers in oncology 2025;15:1671797
SATB2 promotes radiation resistance of esophageal squamous cell carcinoma by regulating epithelial-to-mesenchymal transition via the Wnt/β-catenin pathway.
Lin C, Wu Y, Qian Y, Li J, He Y, Yu H, Xie C, Su H
Frontiers in oncology 2025;15:1543426
Frontiers in oncology 2025;15:1543426
Identification and functional characterization of m1A-related genes in colorectal cancer: implications for prognosis, immune infiltration, and therapeutic strategies.
Sun L, Huangfu L, Li F, Yan Y, Kong R, Ji K, Li J
Frontiers in oncology 2025;15:1532602
Frontiers in oncology 2025;15:1532602
Acetylated Dendrobium huoshanense polysaccharide: a novel inducer of apoptosis in colon cancer cells via Fas-FasL pathway activation and metabolic reprogramming.
Yao L, Gu C, Ge R, Zhang X, Meng X, Wang L, Peng D, Li G
Frontiers in oncology 2025;15:1529868
Frontiers in oncology 2025;15:1529868
BNC1 inhibits the development and progression of gastric cancer by regulating the CCL20/JAK-STAT axis.
Liu L, Xiong L, Peng H, Deng Q, Liu K, Xia S
PeerJ 2025;13:e19477
PeerJ 2025;13:e19477
Hydroxyurea mitigates diabetic kidney disease through mTOR-S6K signaling pathway in STZ-induced diabetic mice.
Cheng W, Wang C, Ma M, Zhou Y
Frontiers in cell and developmental biology 2025;13:1529901
Frontiers in cell and developmental biology 2025;13:1529901
Knockdown of annexin A2 enhances the host cell apoptosis induced by Eimeria tenella.
Wang J, Wang M, Wang Y, Xu M, Liu Y, Zheng M, Zhao R, Bai R, Zhao Y, Zhang L, Lv X, Yang Y, Guan W, Cui X
Frontiers in veterinary science 2025;12:1595384
Frontiers in veterinary science 2025;12:1595384
Jianpi-Qinghua Formula alleviates liver dysfunction by suppression of HBV replication in HepG2.2.15 cells.
Xue J, Zhong B, Wan L, Hu X, Zhang Y, Zhu M, Chen J, Zhao H, Wu X
International journal of molecular and cellular medicine 2025 Summer;14(3):797-807
International journal of molecular and cellular medicine 2025 Summer;14(3):797-807
Synergistic Inhibition of Prostate Cancer Progression in Mice With a Combination of Curcumin and Ursolic Acid in the Diet.
Friedman CA, Saha A, Clark R, Wilder C, Wright J, DiGiovanni J
Molecular carcinogenesis 2025 Sep;64(9):1487-1499
Molecular carcinogenesis 2025 Sep;64(9):1487-1499
Tremella fuciformis Polysaccharides Alleviate Early Brain Injury in Experimental Subarachnoid Hemorrhage by Inhibiting the KDR-Mediated P38 MAPK/NF-κB Pathway.
Wan YH, Cheng ZJ, Fan LX, Yang DH, Chen BL, Chen XX, Zhu Q
Molecular neurobiology 2025 Sep;62(9):11112-11129
Molecular neurobiology 2025 Sep;62(9):11112-11129
Oridonin Ameliorates Metabolic-Dysfunction-Associated Fatty Liver Disease by Inhibiting PANoptosis via Modulating SIRT2/NLRP3 Pathway.
Wang Z, Sun Y, Wang C, Yao J, Hao R, Wang Y, Sun H
Phytotherapy research : PTR 2025 Sep;39(9):4181-4198
Phytotherapy research : PTR 2025 Sep;39(9):4181-4198
A Small Molecular Weight Saccharide Fraction From Panax quinquefolium L. Inhibited Non-Small Cell Lung Cancer via Endoplasmic Reticulum-Stress Mediated Apoptosis.
Lü JL, Liang J, Zhang Y, Liu XQ, Wang WF, Kuang HX, Xia YG
Phytotherapy research : PTR 2025 Sep;39(9):3868-3885
Phytotherapy research : PTR 2025 Sep;39(9):3868-3885
Puerarin Attenuates Osteoarthritis via Multi-Target Regulation of Inflammation, Apoptosis, and ECM Degradation.
Zhang Y, Chen Z, Cheng Y, Zhou Y, Yang Y, Che M, Zhang Y, Li Y
Journal of cellular and molecular medicine 2025 Sep;29(18):e70833
Journal of cellular and molecular medicine 2025 Sep;29(18):e70833
The m6A transferase METTL3 regulates high glucose-induced proliferation and apoptosis of human lens epithelial cells through the lncRNA TUG1/KHSRP/p38MAPK signaling axis.
Li Y, Yao Z, Gao X, Niu Y, Gao Z, Jiang S
Experimental eye research 2025 Sep;258:110492
Experimental eye research 2025 Sep;258:110492
PINK1-mediated mitochondrial autophagy protects lens epithelial cells by reducing ROS and apoptosis.
Liu X, Wang M, Ji Z, Zhu X, Tian J, Chen Y, Cai J, Dong M, Li Z
Experimental eye research 2025 Sep;258:110437
Experimental eye research 2025 Sep;258:110437
Mito-tempo ameliorates tubular injury of diabetic nephropathy via inhibiting mt-dsRNA release and PKR/eIF2α pathway activation.
Duan T, Sun L, Xi Y, Li C, Zhao Q, Xu L, Yang M, Liu C, Xiao L, Deng T, Sun L
Free radical biology & medicine 2025 Sep;237:147-159
Free radical biology & medicine 2025 Sep;237:147-159
Potent Anti-Cancer Activity of Benzo[d]Thiazole-Isatin Conjugates: Induces S Phase Arrest and Cell Necrosis in A549 and HepG2 Cells.
Saeed BA, Ahmed WU, Alshekh AA, Wu L, Lu Y, Mirgany TO, Kadi AA, Alwabli RI, Wang N, Rahman AFMM
Chemistry & biodiversity 2025 Sep;22(9):e202500575
Chemistry & biodiversity 2025 Sep;22(9):e202500575
Zinc Transporter 9 (ZnT9) Improves Obesity-Induced Asthenospermia by Attenuating Endoplasmic Reticulum Stress (ERS).
Liang C, Chen M, Mu Z, Tian X, Zhao W, Hu Y, Su J
Biological trace element research 2025 Sep;203(9):4648-4658
Biological trace element research 2025 Sep;203(9):4648-4658
Knockdown of STK39 inhibits lung cancer brain metastasis by suppressing the CPSF4/NFκB/COX2 pathway.
Shu Y, Dong Y, Li B, Wang Y, Liao Q, Su Z, Wang J, Zuo P, Yuan H, Wang C, Li S, Fan Y, Su X
Journal of neuro-oncology 2025 Sep;174(2):411-430
Journal of neuro-oncology 2025 Sep;174(2):411-430
Magnolin Promotes PINK1-Parkin-mediated Mitophagy in Diffuse Large B-cell Lymphoma Cells via PPAR-γ Pathway.
Zhou X, Guo Q, Qiao Q, Fang X, Jiang Y, Wang X, Hu S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157059
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157059
Rhizoma Panacis Majoris ameliorates rheumatoid arthritis by restoring apoptosis and autophagy dysregulation through reducing HMGB1 expression.
Pang X, Song R, Li Z, Shi X, Zhang Z, Liu Y, Xu H, Song Z, Zhou R, Tang Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:156943
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:156943
Isodeoxyelephantopin Promotes Cell Death in Triple-Negative Breast Cancer by Blocking STAT3 Phosphorylation and Enhancing the Effectiveness of Paclitaxel.
Lin D, Wang H, Wu S, Chen H
Food science & nutrition 2025 Sep;13(9):e70737
Food science & nutrition 2025 Sep;13(9):e70737
Knocking Down SKA1 Inhibits Hepatocellular Carcinoma Progression via Apoptosis: Integrating Single-Cell Transcriptomics With In Vivo and In Vitro Validation.
Luo Q, Zhang Q, Zheng Z, Jiang X
BioFactors (Oxford, England) 2025 Sep-Oct;51(5):e70044
BioFactors (Oxford, England) 2025 Sep-Oct;51(5):e70044
Prepubertal Diabetes Stagnates Testicular Development by Skewing Autophagy Homeostasis in Leydig Cells.
Tang Z, Zheng Y
Cells 2025 Sep 4;14(17)
Cells 2025 Sep 4;14(17)
LncRNA LOXL1-AS1 promotes ovarian cancer progression by enhanced BRIP1 mRNA stability.
Wan S, Su C, Ding J, Liu J, He L, Liu L, Peng Q, Ni G, Zhu W
Medical oncology (Northwood, London, England) 2025 Sep 30;42(11):504
Medical oncology (Northwood, London, England) 2025 Sep 30;42(11):504
Comparison of Quercetin and Isoquercitrin's Anti-Heart Failure Activity via MAPK Inflammatory Pathway and Caspase Apoptosis Pathway.
Guo A, Chen X, Bai Y, Dai Y, Yue H
Pharmaceuticals (Basel, Switzerland) 2025 Sep 26;18(10)
Pharmaceuticals (Basel, Switzerland) 2025 Sep 26;18(10)
Synthesis and antitumor activity of steroid-based imidazolium salts.
Li T, Pan Y, Peng Y, Li A, Huang M, Fu L, Li Y, Zhang Z, Kong L, Deng G
RSC advances 2025 Sep 26;15(43):35913-35920
RSC advances 2025 Sep 26;15(43):35913-35920
Self-Assembling Amphiphilic Peptides Target the VDAC1-Hexokinase-II Complex to Induce Apoptosis in Cervical Carcinoma Cells.
Sun W, Angelova A, Han X, Wang X, Angelov B, Chen Q, Li N, Zou A
Journal of medicinal chemistry 2025 Sep 25;68(18):18857-18868
Journal of medicinal chemistry 2025 Sep 25;68(18):18857-18868
Epalrestat, an aldose reductase inhibitor, mitigates doxorubicin-induced cardiotoxicity by inhibiting glycometabolism.
Zhu J, Wang H, Guan Y, Wang Y, Tan W, Wang J
International immunopharmacology 2025 Sep 23;162:115106
International immunopharmacology 2025 Sep 23;162:115106
Transcriptomic bioinformatics analysis proposes a novel BCL2-MAPK14-TXN oxidative stress diagnostic model of sepsis and identifies TXN as an oxidative stress-related signature gene in sepsis.
Zou Z, Wu M, Peng Y, Luo S
International immunopharmacology 2025 Sep 23;162:115016
International immunopharmacology 2025 Sep 23;162:115016
Puerarin Inhibits Proliferation, Migration and Invasion of Colon Cancer Cells and Induces Apoptosis via Suppression of the PI3K/AKT Signaling Pathway.
Chen L, Li X, Zhao S, Hao M, Wang H, Zhou Z, Xiong X, Yuan D, Luo P, Wang L, Pan D, Shen X, Zhang Y, Chen Y
Pharmaceuticals (Basel, Switzerland) 2025 Sep 16;18(9)
Pharmaceuticals (Basel, Switzerland) 2025 Sep 16;18(9)
Exploring the potential mechanisms of Jinglinzi powder in treating hepatocellular carcinoma based on LC-MS, network pharmacology, molecular docking, and experimental validation.
Liu G, Kuang S, Zhong W, Yang A, Huang X, Xie Y, Zhang X, Li Y, Qin Q, Liu G
Journal of pharmaceutical and biomedical analysis 2025 Sep 15;263:116899
Journal of pharmaceutical and biomedical analysis 2025 Sep 15;263:116899
Dectin-1 Drives Diabetic Retinopathy via Inducing Microglia-Mediated Inflammation and Blood-Retinal Barrier Breakdown.
Zhang L, Zhang S, Li Y, Yang Z, Hu W, Bai H, Zhou W, Wang Z, Li M, Zhang S, Liao R
Developmental neurobiology 2025 Oct;85(4):e22997
Developmental neurobiology 2025 Oct;85(4):e22997
POM121 induces chemoresistance toward cisplatin in non-small cell lung cancer.
Li J, Sun W, Yan D, Hui K, Liu Y
Cytotechnology 2025 Oct;77(5):180
Cytotechnology 2025 Oct;77(5):180
Glycyrrhizic Acid Inhibits Hippocampal Neuron Apoptosis by Activating the PI3K/ AKT Signaling Pathway.
Fu G, Kang X, Lin S
Biochemical genetics 2025 Oct;63(5):4366-4381
Biochemical genetics 2025 Oct;63(5):4366-4381
Oxytocin Regulated Neuroinflammation through OTR/Mitochondria Mediated Pathway to Improve Hypoxia-Induced Brain Injury.
Yang X, Li K, Chen L, Wang L, Wang X, Lu K, Bai Y, Hou Y, Hou J, Wang C, Cheng X, Oldam J, Yu J, Wu J, Sun B
Molecular neurobiology 2025 Oct;62(10):12907-12923
Molecular neurobiology 2025 Oct;62(10):12907-12923
Ribociclib derivative Rib-CA suppresses breast cancer progression via p53-dependent apoptosis.
Song M, Zhou Y, Yu X, Zhang B, Wang S, Asan K, Yang Z, Lin H, Wang J, Song X, Jiang Y, Chen S, Ji J, XiujunWang, Mou Y
Toxicology and applied pharmacology 2025 Oct;503:117475
Toxicology and applied pharmacology 2025 Oct;503:117475
CCP1 Inhibits Pulmonary Fibrosis by Suppressing Fibrotic Progression Through the EIF4B/PI3K/AKT Pathways.
Ren Q, Pan Y, Tian Z, Jiao G, Liu X
Cell biology international 2025 Oct;49(10):1245-1261
Cell biology international 2025 Oct;49(10):1245-1261
MiRNA-634 promotes apoptosis in HEI-OC1 cells by regulating AK4 and AKT/mTOR signaling pathways.
Wang Y, Liu Y
Hearing research 2025 Oct;466:109386
Hearing research 2025 Oct;466:109386
Aspirin-Inspired 6-O-Carboxymethyl-N-Acetylglucosamine: A potent antitumor agent with enhanced efficacy.
Qiao Z, Zhang G, Chen X, Zhang Y, Zhang S, Qin X, Sohail A, Xu X, Liu J, Han B, Wang D, Zhang X, Wang Z
Apoptosis : an international journal on programmed cell death 2025 Oct;30(9-10):2254-2268
Apoptosis : an international journal on programmed cell death 2025 Oct;30(9-10):2254-2268
Honokiol protects against heavy-ion radiation-induced oxidative damage via the thioredoxin system.
Chen Y, Shen R, Zhou X, Xu D, Wu Q, Zhang J, Fang J
Free radical biology & medicine 2025 Oct;238:235-245
Free radical biology & medicine 2025 Oct;238:235-245
Perfluorohexane sulfonate (PFHxS) induces liver cytotoxicity by activating autophagy and endoplasmic reticulum stress-regulated mitochondrial pathway apoptosis.
Chen W, Liu S, Zhou Y, Liu B, Wang W, Chen C, Lou Z, Shen XL
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Oct;204:115657
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Oct;204:115657
miR-204-5p Mitigates Disc Degeneration via SKI-Mediated Modulation of Apoptotic Signaling and Matrix Remodeling in Nucleus Pulposus.
Ran R, Gong CY, Wu ZL, Zhang SB, Zhang K, Zhou WM, Song W, Dong H, Shi YQ, Zhou KS, Zhang HH
The American journal of pathology 2025 Oct;195(10):1905-1920
The American journal of pathology 2025 Oct;195(10):1905-1920
Exploring the mechanism of Levistolide A in the treatment of lung cancer cells based on network analysis, molecular docking and experimental validation.
Zhao L, Wang J, Han Y, Wang Q, Yang W, Zhang Y, Lin Z, Zhu L, Piao J
Bioorganic chemistry 2025 Oct;165:109002
Bioorganic chemistry 2025 Oct;165:109002
Dihydrocapsaicin attenuates oxidative stress and apoptosis in acute myocardial infarction via promoting Raf-1/ASK1 complex formation.
Chen Y, Yu J, He H, Xu W, Yi B, Lin X, Yu Q, Lin Z, Lin J, Lin C, Cai C, Huang K
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157126
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Oct;146:157126
IL-10 alleviates ulcerative colitis by regulating mitochondrial function through reducing ISG15 expression.
He Z, Feng YD, Zhang YX, Gao X, Liu JJ, Liu S, Wu GQ
Cellular signalling 2025 Oct;134:111932
Cellular signalling 2025 Oct;134:111932
Aerobic exercise alleviates chronic allergic airway inflammation by regulating the circMETTL9/EIF4A3/IGFBP3 axis.
Wang H, Jia Y, Ma B, Gao T, Wei H, Li D, Gu J, Chen O, Yue S
Cellular signalling 2025 Oct;134:111889
Cellular signalling 2025 Oct;134:111889
BCL-2 Inhibitor Regulates Number, Function, and Antitumor Immunity of T Cells by Influencing Glycolysis in AML.
Peng X, Li Y, Tang F, Ma Y, Bai J, Li L, Zhang L
Cancer science 2025 Oct;116(10):2657-2676
Cancer science 2025 Oct;116(10):2657-2676
Arbutin improves lung injury in chicks induced by Mycoplasma gallisepticum infection.
Wan Z, Liu T, Cheng A, Li H, Lin R, Zhu E, Huang Y, Liu S, Tang Y, Shan C, Cheng Z
Poultry science 2025 Oct;104(10):105485
Poultry science 2025 Oct;104(10):105485
Development of a CD9-Targeted Radiopharmaceutical for Imaging and Radionuclide Therapy in CD9-Positive Glioma.
Fan L, Shi X, Jiang H, Chen W, Liang M, Wang G, Li W, Wang F, Zhu R, Zhang M
Molecular pharmaceutics 2025 Oct 6;22(10):6368-6380
Molecular pharmaceutics 2025 Oct 6;22(10):6368-6380
Arginyl-fructosyl-glucose (AFG), a major Maillard reaction product of red ginseng, improved kidney and pancreatic injury in vitro and in vivo in type 2 diabetes mellitus.
Tsopmejio ISN, Tang S, Gao XF, Liu Z, Li XD, Qi MH, Zhu HY, Wang Z, Li W
International immunopharmacology 2025 Oct 30;164:115378
International immunopharmacology 2025 Oct 30;164:115378
Novel magnolol-sulforaphane hybrids as potent antitumor agents: synthesis and biological characterization.
Peng Y, Liu B, Guo Y, Chen J, Chen H, Liu X, Huang J, Luo D, Hong Y, Wu D, Chen Z, Lin X, Tao C
RSC medicinal chemistry 2025 Oct 29;16(12):6380-96
RSC medicinal chemistry 2025 Oct 29;16(12):6380-96
Paeoniflorin inhibits glioblastoma proliferation and promotes autophagy through the AKT/mTOR pathway.
Li H, Ouyang J, Zhang Y, Zhang Z, Sun M, Liu R, Qian C
Scientific reports 2025 Oct 29;15(1):37897
Scientific reports 2025 Oct 29;15(1):37897
miR-7704-Enriched Stem Cell-Derived Extracellular Vesicles Attenuate Hyperoxia-Induced Apoptosis and Oxidation in Lung Epithelial Cells.
Chang YH, Wu KC, Ding DC
Current issues in molecular biology 2025 Oct 28;47(11)
Current issues in molecular biology 2025 Oct 28;47(11)
Eleutheroside E Ameliorates D-Gal-Induced Senescence in Human Skin Fibroblasts Through PI3K/AKT Signaling.
Ma X, Han L, Xu M, Feng Y, Liu C, Zhao Y, Zhang M, Xu G, Sun X
Current issues in molecular biology 2025 Oct 28;47(11)
Current issues in molecular biology 2025 Oct 28;47(11)
Mesenchymal stem cells inhibit mitochondrial fission by upregulating armadillo repeat containing 1, ameliorating oxidative stress in renal fibrosis.
Li T, Guo C, Liu Q, Jing F, Zhao M, Xiong H, Li C, Zhang W, Chen B
Stem cell research & therapy 2025 Oct 28;16(1):584
Stem cell research & therapy 2025 Oct 28;16(1):584
Neuroprotective Effects and Mechanisms of Arecoline Against H(2)O(2)-Induced Damage in SH-SY5Y Cells.
Zhang X, Cui J, Sun J, Wang F, Fan B, Lu C
International journal of molecular sciences 2025 Oct 24;26(21)
International journal of molecular sciences 2025 Oct 24;26(21)
Cephalomannine as in vitro and in vivo anticancer agent in mesothelioma cells: mechanisms of action.
Morani F, Dell'Anno I, Daga A, Doccini S, Bisceglia L, Gemignani F, Landi S
BMC cancer 2025 Oct 22;25(1):1625
BMC cancer 2025 Oct 22;25(1):1625
TRAP1 inhibits KANSL3 acetylation to alleviate mitochondrial dysfunction by promoting mitophagy in cardiomyocytes under diabetic conditions.
Zhang X, Cheng S, Li W, Xu X, Huang X, Chen Z, Li Q, Huang W, Zhang L, Ouyang M
Cell communication and signaling : CCS 2025 Oct 2;23(1):414
Cell communication and signaling : CCS 2025 Oct 2;23(1):414
Structural elucidation of an unusual acid heteropolysaccharide with moieties of glucuronogalactoarabinan and glucuronoarabinogalactan from young shoots of Aralia elata (Miq.) Seem.
Liang J, Ji MC, Jiang SL, Ban XT, Liu X, Shang XW, Zhang Y, Huang YX, Kuang HX, Xia YG
Carbohydrate polymers 2025 Oct 15;366:123794
Carbohydrate polymers 2025 Oct 15;366:123794
Epigenetic regulation by WTAPP1 promotes trophoblast dysfunction in gestational diabetes via CNR1/NF-κB activation.
Yang N, Li Y, Zhang J, Gao X, Zhang P, Li W
European journal of medical research 2025 Oct 15;30(1):975
European journal of medical research 2025 Oct 15;30(1):975
Novel E-F ring derivatives of aconitine scaffold as potent Hsp90 inhibitors for the treatment of colorectal cancer.
Zhang Y, Wang YP, Guo S, Li TT, Wang QY, Zhang X, Zheng YM, Wen YQ, Meng FH, Zhang TJ
European journal of medicinal chemistry 2025 Oct 15;296:117895
European journal of medicinal chemistry 2025 Oct 15;296:117895
Pterostilbene as a pyroptosis inducer and tumor microenvironment regulator inhibits glioblastoma and enhances the efficacy of immunotherapy.
Chen Z, Fang XG, Jia LJ, Feng Y, Cheng JH, Luo S, Wen S, Wei JR, Ma SN, Guo XR, Luo J
International immunopharmacology 2025 Oct 10;163:115247
International immunopharmacology 2025 Oct 10;163:115247
Rab26-mediated lysosomal translocation of eEF1A alleviates myocardial hypertrophy and cardiac remodeling.
Tong Y, Li Y, Bi Y, Liu Y, Peng X, He B, Wang X
Life sciences 2025 Oct 1;378:123830
Life sciences 2025 Oct 1;378:123830
Mangiferin targets PFKFB3 to inhibit glioblastoma progression by suppressing glycolysis and PI3K/AKT/mTOR signaling.
Xia J, Li X, Yao J, Song D, Gu Z, Zheng G, Tu C
Brain research bulletin 2025 Oct 1;230:111520
Brain research bulletin 2025 Oct 1;230:111520
Harnessing TP73‑targeted nintedanib: A novel strategy to halt triple‑negative breast cancer via p53‑PPARα/PI3K‑Akt pathway suppression.
Zou X, Li S, Huang S, Niu R, Liu G, Wang Z
International journal of oncology 2025 Nov;67(5)
International journal of oncology 2025 Nov;67(5)
Exosomal gene signature in esophageal carcinoma: Insights from single-cell and bulk RNA sequencing.
Li H, Huang P, Wang Y, Zhang M, Gao D
Translational oncology 2025 Nov;61:102490
Translational oncology 2025 Nov;61:102490
Endoplasmic Reticulum Stress Is Involved in Prostaglandin F2α-Induced Goat Luteal Cell Apoptosis via the IRE1 Pathway.
Min X, Chen L, Wu Y, Zhang Y, Wang Y, Xiong X, Wen X
Reproduction in domestic animals = Zuchthygiene 2025 Nov;60(11):e70143
Reproduction in domestic animals = Zuchthygiene 2025 Nov;60(11):e70143
Pachymic acid alleviates lipopolysaccharide-induced cystitis glandularis by inhibiting ferroptosis.
Tang Y, Hu H, Chen S, Gong Y, Ge B
The Journal of international medical research 2025 Nov;53(11):3000605251396755
The Journal of international medical research 2025 Nov;53(11):3000605251396755
Caulerpin suppresses tumor-associated angiogenesis and tumor growth via Hippo signaling in cervical cancer.
Yang G, Mo Y, Rong H, Guo B, Zha Q, Shuai H, Wang M, Li P
Toxicology and applied pharmacology 2025 Nov;504:117541
Toxicology and applied pharmacology 2025 Nov;504:117541
Expression Patterns of Deubiquitinating Enzymes in Paclitaxel-Treated Lung Cancer Cells.
Kim HY, Choi HS, Baek KH
Cell biology international 2025 Nov;49(11):1507-1517
Cell biology international 2025 Nov;49(11):1507-1517
Hesperidin Inhibits Oxidative Stress and Apoptosis of Granulosa Cells in Polycystic Ovarian Syndrome Through the JAK2/STAT3 and PI3K/AKT Pathways.
Zhang Q, Yang Z, Ou X, Zhang M, Ji R, Wu G
Phytotherapy research : PTR 2025 Nov;39(11):5174-5197
Phytotherapy research : PTR 2025 Nov;39(11):5174-5197
PPM1G promotes chemoresistance in triple negative breast cancer by enhancing YAP signaling.
Huang W, Chen X, Wu H, Zhang C, Zhong W, Li X, Ouyang Y, Chen X, Song L, Wang X, Hu K, Xiong Z
Pharmacological research 2025 Nov;221:107978
Pharmacological research 2025 Nov;221:107978
Protective Effect of Vinegar Powder on (60)Coγ Radiation-Injured Mice and Its Potential Mechanism.
Huang H, Shi Y, Liu X, Hao L, Zhu J, Lu J
The Journal of nutrition 2025 Nov;155(11):3663-3675
The Journal of nutrition 2025 Nov;155(11):3663-3675
PDCD4 exacerbates myocardial ischemia-reperfusion injury via AKT-mediated apoptosis.
Zhang Z, Yang Z, Ge H, Liu C, Fan R, Yuan C, You S, Hong C
Cellular signalling 2025 Nov;135:111999
Cellular signalling 2025 Nov;135:111999
GCN2 promotes fatty acid metabolism through the activation of PI3K/AKT signaling in gastric cancer.
Sun D, Sun X, Wang X, Zhang J, Liu L, Xie J
Cellular signalling 2025 Nov;135:111984
Cellular signalling 2025 Nov;135:111984
DHCR7 Promotes Liver Metastasis of Pancreatic Cancer Through PI3K-Akt Signaling Pathway.
Xie Y, Zhou Z, Song J, Wang C, Ding Y, Qiu Y, Fang L, Cheng H
Cancer science 2025 Nov;116(11):3196-3208
Cancer science 2025 Nov;116(11):3196-3208
Hypoglycemic effect and the post-treatment benefits of carrot pulp fermented by Lactobacillus casei NCU215 in type 2 diabetic mice: insights from gut microbiota regulation and restoration of pancreatic islet function.
Kang X, Xiong T, Yazhou X, Chen Y, Ruan Y, Guan Q
Journal of the science of food and agriculture 2025 Nov;105(14):7826-7839
Journal of the science of food and agriculture 2025 Nov;105(14):7826-7839
Fyn inhibition by TAE684: A synergistic strategy to suppress melanoma and reverse vemurafenib resistance.
Liu W, Zhang X, Liang X, Guo Y, Zhou Z, Zhu S, Peng C, Chen X
Cell death & disease 2025 Nov 6;16(1):796
Cell death & disease 2025 Nov 6;16(1):796
Tetramethylpyrazine ameliorates 5-fluorouracil-Induced cardiotoxicity by inhibiting PANoptosis and suppressing the p38 MAPK/JNK/ERK signaling pathway.
Xie Y, Shen A, Lin H, Zheng H, Lin G, Chen Y, Zhong Y, Liu H, Cheng Y, Wu M, Wei L, Li Q, Peng J
European journal of pharmacology 2025 Nov 5;1006:178180
European journal of pharmacology 2025 Nov 5;1006:178180
H(2)S-Activated Theranostic Platform for Precise Photoablation of Colorectal Tumors with NIR-II Dual-Modal Phototherapy.
Wu K, Sun L, Wu H, Zheng X, Xue Y, Zhang Z, Ma S, Zhao C, Liu Y, Gu X
Journal of medicinal chemistry 2025 Nov 27;68(22):24684-24700
Journal of medicinal chemistry 2025 Nov 27;68(22):24684-24700
Combined Schisandrin B and Temozolomide Treatment Induces Mitochondrial Apoptosis in Glioma Cells.
Tang Z, Guo C, Wen N, Jin H, Dong Y, Xu B, Ma X, Han L, Liu J
Frontiers in bioscience (Landmark edition) 2025 Nov 27;30(11):46410
Frontiers in bioscience (Landmark edition) 2025 Nov 27;30(11):46410
ADRA2A contributes to airway inflammation and apoptosis in asthma through the ERK signaling in vitro and in vivo.
Zhou F, Cai J, Chen L, Tan X, Li C
Journal of inflammation (London, England) 2025 Nov 26;22(1):55
Journal of inflammation (London, England) 2025 Nov 26;22(1):55
tiRNA: An efficient and controllable gene silencing technology via translation inhibition.
Xia B, Cai J, He Z, Zhu Q
New biotechnology 2025 Nov 25;89:177-190
New biotechnology 2025 Nov 25;89:177-190
Pharmacological induction of acetyl-CoA carboxylase 1 autophagic degradation attenuates lipid accumulation and cholangiocarcinoma progression.
Pan Y, Zhang N, Fu X, Wang X, Ma Y, Chen Q, Zhou Y, Liu H, Zhu Y, Xu L, Wang Q, Chen D, Wang Z, Wang L
Journal of experimental & clinical cancer research : CR 2025 Nov 25;44(1):310
Journal of experimental & clinical cancer research : CR 2025 Nov 25;44(1):310
Eucommia ulmoides Oliver (Duzhong) extract ameliorates cerebral ischemic stroke in mice by remodeling intestinal microbiota and metabolites.
Qi X, Deng M, Li M, Ma W, Zhou Y
Metabolic brain disease 2025 Nov 25;40(8):325
Metabolic brain disease 2025 Nov 25;40(8):325
Jianpi Huayu decoction exerts antitumor effects in pancreatic cancer via SCD1-mediated lipid metabolism remodeling/ferroptosis axis.
Chen X, Ren Y, Yao R, Liu S, Fang C, Luo R, Shi H, Zhu X, Lai Y, Zhao X, Zhong C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157389
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157389
hnRNP A1 inhibits colorectal cancer tumorigenesis and progression by regulating fatty acid metabolism and RNA stability.
Ji K, Zhou L, Zhang T, Fan H, Xie G, Man W, Wang C, Tian Y, Chen L, Wang G, Liu M, Zhu B, Zhang W, Yu G
Cell death discovery 2025 Nov 24;11(1):542
Cell death discovery 2025 Nov 24;11(1):542
Metformin mitigates cisplatin-induced premature ovarian insufficiency via Sirt1/Nrf2 activation.
Zheng Y, Fu Z, Yang S, Ma Q, Liu X, Wang Y, Geng T, Hao J, Li X
Medicine 2025 Nov 21;104(47):e46122
Medicine 2025 Nov 21;104(47):e46122
Exploring ASPN as a pan-cancer biomarker with a focus on gastric cancer.
Feng Y, Zhou S, Yang B, Yang J, Wang S, Yu Z, Quan C, Chen J
Discover oncology 2025 Nov 19;16(1):2134
Discover oncology 2025 Nov 19;16(1):2134
Influenza a(H1N1) virus infection impairs syncytiotrophoblast functions by promoting ferroptosis through the TNF-α/ISG15/EGR1 axis.
Zhao Y, Wang Y, Huang K, Wang F, Wang Y
Virology journal 2025 Nov 17;22(1):379
Virology journal 2025 Nov 17;22(1):379
Knockdown of SUCLG2 inhibits glioblastoma proliferation and promotes apoptosis through LMNA acetylation and the mediation of H4K16la lactylation.
Li W, Zhang Q, Yin H, Li Q, Liu S, Wang J, Yuan G, Pan Y
Cell death discovery 2025 Nov 17;11(1):534
Cell death discovery 2025 Nov 17;11(1):534
CDC5L facilitates cardiomyocyte proliferation and ameliorates myocardial ischemia-reperfusion injury via modulation of the FGF10-YAP axis.
Wei T, Wan T, Sun Y, Liang Y, Lin Z, Shen S, Zhang Q, Chen M, Li Y
Acta biochimica et biophysica Sinica 2025 Nov 14;57(12):2110-23
Acta biochimica et biophysica Sinica 2025 Nov 14;57(12):2110-23
GABA treatment promoting cell apoptosis in meningioma correlates with EGFR/BCL-2/BAX axis.
Yang X, Wang L, Wu H, Li C, Zhang L
Journal of neuro-oncology 2025 Nov 11;176(1):78
Journal of neuro-oncology 2025 Nov 11;176(1):78
WTAP-mediated m(6)A modification of PTPN1 contributes to ulcerative colitis pathogenesis through regulating colonic epithelial cell phenotypes.
Zhang Y, Li N, Zhang D, Zhang H
Human cell 2025 Nov 10;39(1):3
Human cell 2025 Nov 10;39(1):3
Large-scale multi-trait genome-wide analysis for inflammatory bowel disease reveals new insights into its molecular mechanisms and emphasizes the roles of systemic immune regulation.
Zhu Z, Shi L, Li H, Wang X, Gao J, Cheng L, Zhang X
Briefings in bioinformatics 2025 Nov 1;26(6)
Briefings in bioinformatics 2025 Nov 1;26(6)
Absence of astrocytic ceruloplasmin reverses the senescence process with aging of learning and memory abilities.
Li ZD, Kang S, Li H, Yu P, Xie R, Li C, Jing Q, Gong Z, Li L, Li Z, Geng M, Zhang Z, Li Y, Chang YZ
Redox biology 2025 May;82:103611
Redox biology 2025 May;82:103611
2-Dodecyl-6-Methoxycyclohexa-2,5-Diene-1,4-Dione from Averrhoa carambola L. roots: Suppressing hepatocellular carcinoma progression through ROS accumulation and p53 pathway-mediated apoptosis.
Chen M, Pang H, Pham TTH, He Y, Gao Q, Liao Y, Zhu C, Chen L, Yan G, Mo S, Han C
Toxicology and applied pharmacology 2025 May;498:117296
Toxicology and applied pharmacology 2025 May;498:117296
Daidzein Attenuates Cadmium-Induced Neurotoxicity via Inhibiting Apoptosis and Mitophagy in the Cerebral Cortex of Sprague-Dawley Rats.
Wen S, Zhao Y, Wang L, Yuan Y
Journal of biochemical and molecular toxicology 2025 May;39(5):e70299
Journal of biochemical and molecular toxicology 2025 May;39(5):e70299
Cyclic RGD modified dextran-quercetin polymer micelles for targeted therapy of breast cancer.
Yang C, Ma H, Liang Z, Zhuang Y, Hu L, Zhang K, Huang L, Li M, Zhang S, Zhen Y
International journal of biological macromolecules 2025 May;308(Pt 1):142272
International journal of biological macromolecules 2025 May;308(Pt 1):142272
Combining photodynamic therapy and ATM inhibition using modified bovine serum albumin: A co-delivery nano platform for eliciting pyroptosis and apoptosis to fuel TNBC therapy.
Feng Y, Wu Z, Liu H, Xu R
International journal of biological macromolecules 2025 May;307(Pt 4):142140
International journal of biological macromolecules 2025 May;307(Pt 4):142140
HKDC1 promotes colorectal cancer progression by regulating RCOR1 expression to activate the Wnt/β-catenin pathway, enhancing proliferation, migration, and epithelial-mesenchymal transition.
Huang S, Pang Q, Zhang Y, Cao J
The Journal of biological chemistry 2025 May;301(5):108478
The Journal of biological chemistry 2025 May;301(5):108478
ECHS1-NOX4 interaction suppresses rotenone-induced dopaminergic neurotoxicity through inhibition of mitochondrial ROS production.
Zhao Z, Wang R, Ge H, Hou L, Hatano T, Hattori N, Su H, Wang Q, Zhao J
Free radical biology & medicine 2025 May;232:56-71
Free radical biology & medicine 2025 May;232:56-71
Formosanin C inhibits triple-negative breast cancer progression by suppressing the phosphorylation of STAT3 and the polarization of M2 macrophages.
Dai YW, Wu ZX, Cheng Y, Wu HD, Chen JW, Lv LX, Wang ZQ, Li HF, Yan CZ, Bao JX, Liu CH, Dai XX
Breast cancer research and treatment 2025 May;211(1):71-89
Breast cancer research and treatment 2025 May;211(1):71-89
Nicotine Ameliorates α-Synuclein Preformed Fibril-Induced Behavioral Deficits and Pathological Features in Mice.
Huang Z, Pan Y, Ma K, Luo H, Zong Q, Wu Z, Zhu Z, Guan Y
Applied biochemistry and biotechnology 2025 May;197(5):3026-3047
Applied biochemistry and biotechnology 2025 May;197(5):3026-3047
USP51/GRP78/ABCB1 axis confers chemoresistance through decreasing doxorubicin accumulation in triple-negative breast cancer cells.
Ou Y, Zhang K, Shuai Q, Wang C, Hu H, Cao L, Qi C, Guo M, Li Z, Shi J, Liu Y, Zuo S, Chen X, Wang Y, Feng M, Wang H, Sun P, Shi Y, Yang G, Yang S
Acta pharmaceutica Sinica. B 2025 May;15(5):2593-2611
Acta pharmaceutica Sinica. B 2025 May;15(5):2593-2611
Bisphenol AF induces cell cycle arrest and apoptosis in TM3 Leydig cells via the p53 signaling pathway.
Li C, Luo H, Chen M, Lin F, Ren X, Huang Y, Zhou L
Reproductive toxicology (Elmsford, N.Y.) 2025 May;134:108882
Reproductive toxicology (Elmsford, N.Y.) 2025 May;134:108882
Trehalose attenuates testicular aging by activating autophagy and improving mitochondrial quality.
Xi H, Shan W, Li M, Wang Z, Li Y
Andrology 2025 May;13(4):911-920
Andrology 2025 May;13(4):911-920
LMTK2 and CRB1 are two novel risk genes for Alzheimer's disease in Han Chinese.
Xiao X, Liu H, Yao R, Li Y, Liao X, Liu Y, Zhou Y, Wang J, Tang B, Jiao B, Li J, Shen L, Luo S
The journal of prevention of Alzheimer's disease 2025 May;12(5):100087
The journal of prevention of Alzheimer's disease 2025 May;12(5):100087
Icaritin Represses Autophagy to Promote Colorectal Cancer Cell Apoptosis and Sensitized Low-Temperature Photothermal Therapy via Targeting HSP90-TXNDC9 Interactions.
He D, Chen S, Wang X, Wen X, Gong C, Liu L, He G
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(20):e2412953
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(20):e2412953
Transglutaminase 2 nuclear localization enhances glioblastoma radiation resistance.
Sun C, Du Z, Yang W, Wang Q
Discover oncology 2025 May 30;16(1):952
Discover oncology 2025 May 30;16(1):952
Effect of periplocin on malignant behavior of oral squamous cell carcinoma cells.
Zhao Q, Lu Y, Lu H, Wang D, Shang H, Yao M, Liu T
Translational cancer research 2025 May 30;14(5):2722-2736
Translational cancer research 2025 May 30;14(5):2722-2736
AMH regulates granulosa cell function via ESR2/ p38-MAPK signaling pathway in sheep.
Xu H, Cai Y, Yang H, Zhang C, Liu W, Zhao B, Wang F, Zhang Y
Communications biology 2025 May 29;8(1):824
Communications biology 2025 May 29;8(1):824
Potential mechanisms by which Jiawei Lianpu Yin inhibits Helicobacter pylori colonization and alleviates gastric mucosal inflammation and damage: Integrated transcriptomics, network pharmacology, and experimental validation.
Zhang X, Wang L, Huang L, Cao G, Huang C, Duan Y, Lyu W
Journal of ethnopharmacology 2025 May 28;348:119793
Journal of ethnopharmacology 2025 May 28;348:119793
Overexpression of c-Myc triggers p62 aggregation-mediated mitochondrial mitophagy in cabozantinib resistance of hepatocellular carcinoma.
Yang K, Zhang X, Yang K, Liu S, Zhang J, Fu Y, Liu T, Wu K, Li J, Liu C, Huang Q, Qu K
Molecular medicine (Cambridge, Mass.) 2025 May 27;31(1):209
Molecular medicine (Cambridge, Mass.) 2025 May 27;31(1):209
Effects of venetoclax, a BCL2 inhibitor, in systemic chronic active Epstein-Barr virus disease.
Ohashi A, Nishio M, Yoshimori M, Koike K, Kurata M, Tamai H, Imadome KI, Arai A
Scientific reports 2025 May 27;15(1):18569
Scientific reports 2025 May 27;15(1):18569
Melatonin ameliorates ischemic brain injury in experimental stroke by regulation of miR-221 and ATG7 axis.
Liu X, Zhang Y, Ma Y, Han C, Tan S, Liu B, Song H, Yuan Y, Long C, Zhao C
Biochemical and biophysical research communications 2025 May 26;760:151706
Biochemical and biophysical research communications 2025 May 26;760:151706
Long non-coding RNA HOXA11-AS inhibits apoptosis, induces proliferation, and promotes autophagy via the miR-214-3p/ATG12 axis in acute T lymphoblastic leukemia.
Zhang R, Zhang Y, Li X, Wang S, Li J, Shao S, Liu B, Guo W, Shi M
Journal of molecular histology 2025 May 26;56(3):170
Journal of molecular histology 2025 May 26;56(3):170
The oncogenic role of TIMM8A in cancer and the mechanistic insights into the function in breast cancer cells.
Wang W, Liu M, Wu H, Li J, Lv W, Li C, Du C, Feng C, Zhang Y, Cai Y, Jia Y, Hu Y, Qu J, Zhang S, Wu F
Scientific reports 2025 May 26;15(1):18374
Scientific reports 2025 May 26;15(1):18374
Integration of network pharmacology, transcriptomics, and experimental verification to investigate the mechanism of action of cepharanthine hydrochloride against prostate cancer.
Dong Z, Chang X, Luo X, Li H, Deng M, Huang Z, Chen T, Chen Y, Sun B, Wu Y, Wu R, Wu Q, Zhu J, Zheng J
Scientific reports 2025 May 24;15(1):18115
Scientific reports 2025 May 24;15(1):18115
Inhibitory Effect and Mechanism of the Down-Regulation of TRIM32 in Colorectal Cancer.
Ning J, Cai X, Su Y, Fan X, Shen M
International journal of molecular sciences 2025 May 23;26(11)
International journal of molecular sciences 2025 May 23;26(11)
Epigenetic activation of PTEN by valproic acid inhibits PI3K/AKT signaling and Burkitt lymphoma cell growth.
Li C, Liu S, Gao J, Xu Y, Peng Q, Weng D, Wang D, Yang W, Yi P, Lin Z, Chen J
Gene 2025 May 20;950:149369
Gene 2025 May 20;950:149369
USP14 inhibits mitophagy and promotes tumorigenesis and chemosensitivity through deubiquitinating BAG4 in microsatellite instability-high colorectal cancer.
Wang Z, Yu C, Xie G, Tao K, Yin Z, Lv Q
Molecular medicine (Cambridge, Mass.) 2025 May 2;31(1):163
Molecular medicine (Cambridge, Mass.) 2025 May 2;31(1):163
Anlotinib enhances the efficacy of KRAS-G12C inhibitors through c-Myc/ORC2 axis inhibition in non-small cell lung cancer.
Liu H, Zhou C, Lu J, Liu Y, Zou P, Zhu L, Lei H, Han B
Cell death & disease 2025 May 2;16(1):356
Cell death & disease 2025 May 2;16(1):356
Therapeutic potential of Sweroside in postmenopausal osteoporosis: Inhibition of osteoclast differentiation and promotion of osteoclast apoptosis via NF-κB and MAPK pathways.
Wu Z, Wang J, Chen K, Yu Q, Zhou X, Wu L, Sun C
International immunopharmacology 2025 May 16;155:114630
International immunopharmacology 2025 May 16;155:114630
TRx0237 induces apoptosis and enhances anti-PD-1 immunotherapeutic efficacy in anaplastic thyroid Cancer.
Ning Q, Liu J, Liu S, Zou Q, Li K, Li Z
International immunopharmacology 2025 May 16;155:114610
International immunopharmacology 2025 May 16;155:114610
Structural characterizations and antiaging activities of hydrolyzed low-molecular-weight polysaccharides from Polygoni Multiflori Radix Praeparata.
Xu W, Li XJ, Zhong YS, He JQ, Xie W, Kang YK, Ying HZ, Yu CH
Carbohydrate polymers 2025 May 15;356:123381
Carbohydrate polymers 2025 May 15;356:123381
Research on the functions and potential mechanisms of STAT3 in chronic myelogenous leukemia.
Feng X, Qin Y, Feng Y, Zhuo Y
Discover oncology 2025 May 12;16(1):739
Discover oncology 2025 May 12;16(1):739
Self-Assembly Oligomeric Anthocyanin-Based Core-Shell Structure of Nanoparticles Enhances the Delivery and Efficacy of Berberine in Osteoarthritis.
Huang Y, Wang X, Chen H, Wu Y, Lv L, Chen F, Lei H, Xing C
ACS biomaterials science & engineering 2025 May 12;11(5):2739-2752
ACS biomaterials science & engineering 2025 May 12;11(5):2739-2752
Screening Isodon rubescens-Derived Vesicles Harvested at Different Periods as Carriers for the Treatment of Colitis-Associated Cancer.
Zhang J, Zhang Y, Ma X, Wang H, Zhang C, Pan C
ACS biomaterials science & engineering 2025 May 12;11(5):2653-2663
ACS biomaterials science & engineering 2025 May 12;11(5):2653-2663
Liraglutide Inhibits Autophagy to Ameliorate Post-Cardiac Arrest Brain Injury and Ferroptosis in Rats.
Xing C, Fan X, Liu M, Chen Y, Jia J, Li W, Yu H, Zhou J
Neurochemical research 2025 May 11;50(3):161
Neurochemical research 2025 May 11;50(3):161
Conditional sequential delivery of ginkgetin and rapamycin orchestrates inflammation and autophagy to alleviate intervertebral disc degeneration.
Chen J, Gan X, Su S, Jiao S, Gong Z, Liu Z, Wu X, Jiang J, Zhang J, Wan J
Journal of controlled release : official journal of the Controlled Release Society 2025 May 10;381:113556
Journal of controlled release : official journal of the Controlled Release Society 2025 May 10;381:113556
Geraniin attenuates isoproterenol-induced cardiac hypertrophy by inhibiting inflammation, oxidative stress and cellular apoptosis.
Ding J, Zhang S, Li Q, Xia B, Wu J, Lu X, Huang C, Yuan X, You Q
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2025 May 1;29(3):307-319
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2025 May 1;29(3):307-319
Inhibition of microRNA-139-5p by glucagon-like peptide-1 ameliorates oxidative stress-induced vascular endothelial cell damage via targeting SOD1/GCLc.
Zhang J, Mo J, Liu Y, Meng X, Tang W, Fu L, Xiong J, Mo Z
Endocrine connections 2025 May 1;14(5)
Endocrine connections 2025 May 1;14(5)
FABP3 promotes cell apoptosis and oxidative stress by regulating ferroptosis in lens epithelial cells.
Wang Q, Zhang C, Yu B, Zhang Y, Guo Y
Free radical research 2025 Mar;59(3):250-261
Free radical research 2025 Mar;59(3):250-261
Cellular heterogeneity and communication networks in gastric cancer: Single-cell analysis reveals β-hydroxybutyrylation-associated genes and immune infiltration characteristics.
Hu Y, Xu J, Lv J, Qin Y, Lu Y, Cen F, Yang H, Chen K, Xia S
Translational oncology 2025 Mar;53:102270
Translational oncology 2025 Mar;53:102270
Oleanolic acid improves the in vitro developmental competence of early porcine embryos by reducing oxidative stress and ameliorating mitochondrial function.
Dong YW, Qu HX, Wang YQ, Qi JJ, Wei HK, Sun BX, Sun H, Liang S
Animal bioscience 2025 Mar;38(3):431-443
Animal bioscience 2025 Mar;38(3):431-443
Shenmai Injection Reduces Cardiomyocyte Apoptosis Induced by Doxorubicin through miR-30a/Bcl-2.
Zhang XN, Li YY, Lyu SC, Jia QJ, Zhang JP, Liu LT
Chinese journal of integrative medicine 2025 Mar;31(3):240-250
Chinese journal of integrative medicine 2025 Mar;31(3):240-250
CD39 Contributes to the Ability of Cell Invasion in Heterogeneity of Colorectal Cancer.
Li X, Shen Y, Lang J, Wu J, Qian Z, Shen G, Shen Y
Journal of cellular and molecular medicine 2025 Mar;29(5):e70486
Journal of cellular and molecular medicine 2025 Mar;29(5):e70486
Mild hypothermia (35°C) reduces myocardial ischemia-reperfusion injury and attenuates hypoxia induced apoptosis of H9C2 cardiomyocytes by changing the phosphorylation level of Connexin43 (Cx43) protein.
Lu Y, Wang F, Xiao N, Fan Z, Xiong L, Kou J, Wang T, Li D
African health sciences 2025 Mar;25(1):205-229
African health sciences 2025 Mar;25(1):205-229
Aerobic Exercise Affected Lymphocyte Apoptosis by Modulating ROS Release and NLRP3 Inflammasome Activation.
Lian X, Guo Z, Liu J, Zeng W
Bulletin of experimental biology and medicine 2025 Mar;178(5):685-690
Bulletin of experimental biology and medicine 2025 Mar;178(5):685-690
SEPT5 overexpression predicts poor prognosis and promotes progression through feedback regulation of HIF-1α in clear cell renal cell carcinoma.
Liu W, Ni Y, Wang W, Cui K, Duan Q, Bai Z, Shahzad A, Liu X, Dong Y, Xu Z, Zhang J, Peng D, Teng Z, Gao Y, Yang Z, Zhang Q
Cellular signalling 2025 Mar;127:111591
Cellular signalling 2025 Mar;127:111591
Microglia-Derived Interleukin-6 Triggers Astrocyte Apoptosis in the Hippocampus and Mediates Depression-Like Behavior.
Shen SY, Liang LF, Shi TL, Shen ZQ, Yin SY, Zhang JR, Li W, Mi WL, Wang YQ, Zhang YQ, Yu J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(11):e2412556
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(11):e2412556
FABP4 Mediates Inflammation to Regulate Endometrial Epithelial Cell Function During Early Gestation in Sheep.
Chen Y, Liu C, Liu Z, Yu H, Peng X, Wang J, Hu G
Veterinary medicine and science 2025 Mar;11(2):e70193
Veterinary medicine and science 2025 Mar;11(2):e70193
Oridonin Alleviates Doxorubicin-Induced Cardiotoxicity by Inhibiting p38 MAPK/MMP3 Signaling Pathway.
Hou X, Xie S, Zhou N, Wei S, Yang Y, Luo Z, Liu S, Liu J, Xie N, Li W, Zhang B
Chemical biology & drug design 2025 Mar;105(3):e70093
Chemical biology & drug design 2025 Mar;105(3):e70093
Cornuside as a promising therapeutic agent for diabetic kidney disease: Targeting regulation of Ca(2+) disorder-mediated renal tubular epithelial cells apoptosis.
Gao G, Su X, Liu S, Wang P, Chen JJ, Liu T, Xu J, Zhang Z, Zhang X, Xie Z
International immunopharmacology 2025 Mar 6;149:114190
International immunopharmacology 2025 Mar 6;149:114190
Indole-3-Propionic Acid Attenuates Neuroinflammation and Cognitive Deficits by Inhibiting the RAGE-JAK2-STAT3 Signaling Pathway.
Hao Z, Ji R, Su Y, Wang H, Yang W, Zhang S, Liu Y, Ma S, Guan F, Cui Y
Journal of agricultural and food chemistry 2025 Mar 5;73(9):5208-5222
Journal of agricultural and food chemistry 2025 Mar 5;73(9):5208-5222
The LncRNA lnc-POTEM-4:14 promotes HCC progression by interacting with FOXK1.
Peng B, Quan Z, Liang L, Liu M, Hu K, Chen S, Xie Q, Qin J, Chen J, Liao L, He S, Li Z
Scientific reports 2025 Mar 5;15(1):7672
Scientific reports 2025 Mar 5;15(1):7672
Probiotic nanovesicles encapsulating baicalin: a strategy to overcome colorectal cancer.
Li Y, Zhao X, Wang D, Wang R, Zhu R, You X, Liu X, Li Y
Letters in applied microbiology 2025 Mar 3;78(3)
Letters in applied microbiology 2025 Mar 3;78(3)
PTPN23-dependent activation of PI3KC2α is a therapeutic vulnerability of BRAF-mutant cancers.
He Y, Li W, Zhang M, Wang H, Lin P, Yu Y, Huang B, Hao M, He J, Kong W, Luo D, Xu T, Wang J, Huang Y, Zhao Q, Liu Y, Zhang J, Nian Y, Zhang L, Zhu B, Yin C
The Journal of experimental medicine 2025 Mar 3;222(3)
The Journal of experimental medicine 2025 Mar 3;222(3)
N-(3-Oxododecanoyl)-Homoserine Lactone Induces Intestinal Barrier Damage in Piglets via the Lipid Raft-Mediated Apoptosis Pathway.
Yang Y, Zhang X, Yang J, Wu Z, Li J, Song R, Meng C, Zhu G
Veterinary sciences 2025 Mar 3;12(3)
Veterinary sciences 2025 Mar 3;12(3)
Fatty acid synthase inhibitor cerulenin attenuates glioblastoma progression by reducing EMT and stemness phenotypes, inducing oxidative and ER stress response, and targeting PI3K/AKT/NF-κB axis.
Pekmez M, Mete ŞB, Aksüt Y, Öğütcü İ, Baştürk FN, Gerçek YC, Şengelen A
Medical oncology (Northwood, London, England) 2025 Mar 25;42(5):136
Medical oncology (Northwood, London, England) 2025 Mar 25;42(5):136
FDX1 overexpression inhibits the growth and metastasis of clear cell renal cell carcinoma by upregulating FMR1 expression.
Yang W, Wu C, Jiang C, Jing T, Lu M, Xia D, Peng D
Cell death discovery 2025 Mar 21;11(1):115
Cell death discovery 2025 Mar 21;11(1):115
Resolvin D1 accelerates resolution of neuroinflammation by inhibiting microglia activation through the BDNF/TrkB signaling pathway.
Bo C, Liu X, Liu Y, Xu L, Huang Q
European journal of medical research 2025 Mar 20;30(1):189
European journal of medical research 2025 Mar 20;30(1):189
S-nitrosylation of peroxiredoxin 2 exacerbates hyperuricemia-induced renal injury through regulation of mitochondrial homeostasis.
Han F, Dong Y, Liu Q, Song L, Guo H, Zhu L, Sun B, Zhao W, Chen L
Free radical biology & medicine 2025 Mar 16;230:66-78
Free radical biology & medicine 2025 Mar 16;230:66-78
Self-assembled injectable Icariin@ Ti(3)C(2)Tx/doxorubicin hydrogel preserving osteogenesis while synergizing photodynamic and chemodynamic therapy for osteosarcoma.
Fu J, Chen H, Zhao Y, Xi H, Huang Y, Liu C, Wu Y, Song W, Liu X, Du B, Sun G
Journal of materials science. Materials in medicine 2025 Mar 15;36(1):28
Journal of materials science. Materials in medicine 2025 Mar 15;36(1):28
Tasquinimod promotes the sensitivity of ovarian cancer cells to cisplatin by down-regulating the HDAC4/p21 pathway.
Li Z, Wu YH, Guo YQ, Min XJ, Lin Y
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2025 Mar 1;29(2):191-204
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2025 Mar 1;29(2):191-204
Modification of RNF183 via m6A Methylation Mediates Podocyte Dysfunction in Diabetic Nephropathy by Regulating PKM2 Ubiquitination and Degradation.
Guo D, Pang Y, Wang W, Feng Y, Wang L, Sun Y, Hao J, Li F, Zhao S
Cells 2025 Mar 1;14(5)
Cells 2025 Mar 1;14(5)
Silencing ribosome biogenesis regulator 1 homolog (RRS1) inhibits angiogenesis and cisplatin resistance of lung cancer cells by activating ferroptosis mediated by p53 pathway.
Lin L, Zou Y, Zhang D
Tissue & cell 2025 Jun;94:102796
Tissue & cell 2025 Jun;94:102796
Administration with Yangxinshi ameliorates the progression of atrial fibrillation by affecting atrial remodeling and oxidative stress via the activation of the PI3K/AKT signaling.
Zhang B, Hou J, Dong L, Sun M, Dong Y, Dong Y
Cytotechnology 2025 Jun;77(3):121
Cytotechnology 2025 Jun;77(3):121
Targeting MAD2B as a strategy for ischemic stroke therapy.
Zhang L, Cui H, Hu W, Meng X, Zhang C
Journal of advanced research 2025 Jun;72:369-385
Journal of advanced research 2025 Jun;72:369-385
CtBP2 Regulates Wnt Signal Through EGR1 to Influence the Proliferation and Apoptosis of DLBCL Cells.
Dong J, Li L, Zhang X, Yin X, Chen Z
Molecular carcinogenesis 2025 Jun;64(6):959-969
Molecular carcinogenesis 2025 Jun;64(6):959-969
Melatonin ameliorates PM2.5-induced airway inflammation and apoptosis by PERK/eIF2α/ATF4/CHOP in chronic obstructive pulmonary disease mice.
Shi M, Liu K, Li X, Zeng XL, Liu XJ
Toxicology and applied pharmacology 2025 Jun;499:117314
Toxicology and applied pharmacology 2025 Jun;499:117314
Exogenous hydrogen sulfide improves non-alcoholic fatty liver disease by inhibiting endoplasmic reticulum stress/NLRP3 inflammasome pathway.
Fu X, Zhang Q, Chen Y, Li Y, Wang H
Molecular and cellular biochemistry 2025 Jun;480(6):3813-3839
Molecular and cellular biochemistry 2025 Jun;480(6):3813-3839
Hamayou () protein hydrolysate ameliorates depression by regulating the mitogen-activated protein kinase pathway.
Weijia LI, Jing LU, Chao MA, Mengmeng L, Ke P, Hongyan C, Zhe L, Guangfu L
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2025 Jun;45(3):493-507
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2025 Jun;45(3):493-507
Astaxanthin Alleviates Lung Injury by Regulating Oxidative Stress, Inflammatory Response, P2X7 Receptor, NF-κB, Bcl-2, and Caspase-3 in LPS-Induced Endotoxemia.
Ozkanlar S, Ozkanlar Y, Kara A, Dalkilinc E
Environmental toxicology 2025 Jun;40(6):924-934
Environmental toxicology 2025 Jun;40(6):924-934
SKIL Promotes Pancreatic Cancer Metastasis by Inhibiting TSPYL2 to Activate the TGF-β Pathway.
Wang C, Song W, Zhang Y, Deng H, Zhou Z, Zhu J, Wang X
Cancer innovation 2025 Jun;4(3):e70011
Cancer innovation 2025 Jun;4(3):e70011
Conjugated therapy with coaxially printed neural stem cell-laden microfibers and umbilical cord mesenchymal stem cell derived exosomes on complete transactional spinal cord defects.
Li X, Zhang J, Zhang Y, Guo L, Gao M, Wang Y, Qiu W, Yuan Y, Zhu J, Liu B, Xiong H, Xu T, Xu R
Materials today. Bio 2025 Jun;32:101639
Materials today. Bio 2025 Jun;32:101639
A pectic polysaccharide from wax gourd peel improves ethanol-induced gastric ulcer injury in mice via the PI3K/AKT signaling pathway.
Luo B, Cai M, Huang H, Zhang Y, Chen P, Ji R, Wang F, Liao P, Xian M
International journal of biological macromolecules 2025 Jun;316(Pt 2):144755
International journal of biological macromolecules 2025 Jun;316(Pt 2):144755
Ionized Angelica polysaccharides derivatives slow tumor growth in vivo and induce the apoptosis of HepG2 cells via mitochondria death receptor-mediated pathways in vitro.
Yang Y, Wang J, Zhang Y, Xue W, Chen Y, Yue J, Wen Y, Feng R, Tan C
International journal of biological macromolecules 2025 Jun;315(Pt 1):144297
International journal of biological macromolecules 2025 Jun;315(Pt 1):144297
Environmental responsive dual-drug synergistic and dual-targeted polymer micelles based on chondroitin sulfate for treatment of breast cancer.
Hu L, Ma H, Yang C, Wang K, Ji X, Xu T, Xu H, Zhao Y, Zhen Y
International journal of biological macromolecules 2025 Jun;311(Pt 4):144083
International journal of biological macromolecules 2025 Jun;311(Pt 4):144083
Ochratoxin A-induced mitochondrial pathway apoptosis and ferroptosis by promoting glycolysis.
Zhou Y, Chen W, Feng S, Liu S, Chen C, Yao B, Shen XL
Apoptosis : an international journal on programmed cell death 2025 Jun;30(5-6):1440-1452
Apoptosis : an international journal on programmed cell death 2025 Jun;30(5-6):1440-1452
Mechanistic study of Liquiritigenin inhibiting bladder cancer cell proliferation and migration by regulating STING1.
Li W, Yin Q, Qiu Y, Liu J, Wang J, Li C, Zhang D, Zhang P, Lv H, Lv Y, Wang Y
Cancer genetics 2025 Jun;294-295:156-170
Cancer genetics 2025 Jun;294-295:156-170
LncRNA SNHG14 Regulated by ZNF460 Promotes Gastric Cancer Progression and Metastasis by Targeting the miR-206/FNDC3A Axis.
Liu B, Lu T, Zhang G, Dong X, Yu M, Cai H
Journal of cellular and molecular medicine 2025 Jun;29(11):e70652
Journal of cellular and molecular medicine 2025 Jun;29(11):e70652
Spatial alteration of metabolites in diabetic cortical cataracts: New insight into lactate.
Li P, Wu M, Wang R, Zhang G, Kang L, Guan H, Ji M
Experimental eye research 2025 Jun;255:110361
Experimental eye research 2025 Jun;255:110361
Irisin alleviates steroid-induced vascular dysfunction by regulating the αVβ5-c-Abl-Caveolin-1 signaling pathway.
Fang L, Li W, Zhao H, Wang W, Gao H, Wang P, Zhang X, Lv R, Xu F, Chen J, Lyu L, Chen Y
Biochemical pharmacology 2025 Jun;236:116870
Biochemical pharmacology 2025 Jun;236:116870
Resveratrol interrupts Wnt/β-catenin signalling in cervical cancer by activating ten-eleven translocation 5-methylcytosine dioxygenase 1.
Ren J, Xie L, Zhu X, Chen X, Wei L, Xu D, Qiao K, Min S, Ding Y, Tan Y
Cytokine 2025 Jun;190:156930
Cytokine 2025 Jun;190:156930
Both carvedilol and cimetidine alleviate cisplatin-induced nephrotoxicity via downregulating OCT2.
Wu H, Ning Y, Sun Z, Ji J, Lu M, Jiao X, Xu X, Ding X, Cheng X, Yu X
Biochimica et biophysica acta. Molecular basis of disease 2025 Jun;1871(5):167754
Biochimica et biophysica acta. Molecular basis of disease 2025 Jun;1871(5):167754
Fufang-Biejia-Ruangan tablet targeting both cancer-associated fibroblasts and tumor cells by HIPPO-PI3K/AKT cascades in intrahepatic cholangiocarcinoma treatment.
Xu Y, Li X, Cui M, Pan T, Zheng S, Shang Z, Yin D, Xu Y, Yang Z, Wang J, Song X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156690
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156690
Schisandrin B regulates mitochondrial dynamics via AKT1 activation and mitochondrial targeting to ameliorate renal ischemia-reperfusion injury.
Xu C, Wang H, Wang H, Man J, Deng Y, Li Y, Cheng K, Niu J, Gui H, Fu S, Yang L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156672
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156672
L-Theanine attenuates oxidative damage induced by heat stress through the PI3K/AKT/Nrf2 signaling pathway in skeletal muscle cells.
Wu Q, Wan X, Wang D, Ma M, Hu X, Chen X, Ding X, Zhang C
Poultry science 2025 Jun;104(6):105140
Poultry science 2025 Jun;104(6):105140
Acevaltrate overcomes myeloma resistance to bortezomib via pyroptosis by promoting BAX translocalization to mitochondria.
Wang Y, Cui Y, Liu Z, Liu L, Huang Z, Wang Q, Mao X
European journal of pharmacology 2025 Jun 5;996:177572
European journal of pharmacology 2025 Jun 5;996:177572
miR-210 Regulates Autophagy Through the AMPK/mTOR Signaling Pathway, Reduces Neuronal Cell Death and Inflammatory Responses, and Enhances Functional Recovery Following Cerebral Hemorrhage in Mice.
Wang Y, Jiang L, Tian JJ, Zhu LL, Dai HJ, Guo C, Zhou LY, Wang L, Lu Y, Zhang Y
Neurochemical research 2025 Jun 5;50(3):180
Neurochemical research 2025 Jun 5;50(3):180
Exercise-induced irisin ameliorates cognitive impairment following chronic cerebral hypoperfusion by suppressing neuroinflammation and hippocampal neuronal apoptosis.
Xiao W, Yang Y, Bai L, Yang P, Li R, Yang D, Li F, Quan L, Liang Q, Yan Y, Qi T, Liang F
Journal of neuroinflammation 2025 Jun 28;22(1):168
Journal of neuroinflammation 2025 Jun 28;22(1):168
Cytohesin-4/ARF6 facilitates the progression of acute myeloid leukemia through activating PIK3R5/PI3K/AKT pathway.
Qiu XF, He CM, Zeng YM, Deng XL, Liang GL, Zhong MX, Zou M, Xiong XJ, Zhang JD, Ye Y, Niu Q, Chen XL
iScience 2025 Jun 20;28(6):112634
iScience 2025 Jun 20;28(6):112634
Photothermal Hyperthermia Suppresses Liver Tumor Growth Via Hippo Signaling Pathway-Dependent Inhibition of Cell Proliferation and Induction of Apoptosis.
Li J, Qin Y, Yang Y, Chen H, Li M, Liu Y, Liu B, Shang J, Zhang Y, Han T, Hu Y, Ren F
Biological procedures online 2025 Jun 17;27(1):22
Biological procedures online 2025 Jun 17;27(1):22
Halicin Reduces the Warburg Effect and Overcomes Drug Resistance by Activating the Pyruvate Kinase M2 Pathway for Triple-Negative Breast Cancer Treatment.
Gu H, You W, Zhou XH, Wang Z, Huo SH, Nie X, Feng YB, You YZ, Zhan X, Xia L
ACS omega 2025 Jun 17;10(23):24541-24554
ACS omega 2025 Jun 17;10(23):24541-24554
The miR-21-5p/DUSP8/MAPK signaling pathway mediates inflammation and apoptosis in vascular endothelial cells induced by intermittent hypoxia and contributes to the protective effects of N-acetylcysteine.
Zhao Y, Lv R, He Y, Dong N, Wang X, Pu J, Yu Q
European journal of pharmacology 2025 Jun 15;997:177462
European journal of pharmacology 2025 Jun 15;997:177462
Genome-guided discovery of coublibactins from Nocardia coubleae and their gallium complexes with potent antileukemic activity.
Tao Q, Cai T, Xiao Y, Han T, Shen L, Cheng C, Xu S, Li A, Zhang P, Chen J, Zhang Y, Tong Q, Cai X
Bioorganic chemistry 2025 Jun 15;160:108508
Bioorganic chemistry 2025 Jun 15;160:108508
Overexpression of the circadian gene Bmal1 regulates the Nrf2/HO-1 oxidative stress pathway to alleviate inflammation and apoptosis in PC12 cells following cerebral ischemia-reperfusion injury.
Zeng F, Wang M, Li Z, Zhang Y
Medicine 2025 Jun 13;104(24):e42763
Medicine 2025 Jun 13;104(24):e42763
ATP-responsive tumor targeted lipid nanoparticle for enhanced siRNA delivery and improved treatment efficacy in melanoma.
Xiong L, Chen S, Li S, He D, Wang Y, Zhang Q, He Z, Li M, He Q
Journal of controlled release : official journal of the Controlled Release Society 2025 Jun 10;382:113622
Journal of controlled release : official journal of the Controlled Release Society 2025 Jun 10;382:113622
AMPK-YAP signaling pathway-mediated mitochondrial dynamics and mitophagy participate in the protective effect of silibinin on HaCaT cells under high glucose conditions.
Wang X, Sun X, Zhang X, Shen N, Xia J, Wang L, Ye S
Archives of biochemistry and biophysics 2025 Jul;769:110433
Archives of biochemistry and biophysics 2025 Jul;769:110433
Potential of Ginger Oil to Prevent 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone-Induced Lung Cancer Through Gut Microbiota Modulation and Inflammatory Response Inhibition.
Ding Y, Zhang L, Zhao W, Wang T, Shi Y, Zhuang C, Qu Z
Molecular nutrition & food research 2025 Jul;69(13):e70103
Molecular nutrition & food research 2025 Jul;69(13):e70103
Single-cell RNA sequencing reveals anterograde trans-synaptic degeneration and exacerbated synaptic remodeling in myopia.
Zhang R, Xie Y, Zhang M, Li Z, Guo L, Wei H, Li X, Xin J, Yang Z, Wen Y, Hao J, Li X, Yin X, Jiang W, Bi H, Guo D
Experimental & molecular medicine 2025 Jul;57(7):1536-1554
Experimental & molecular medicine 2025 Jul;57(7):1536-1554
Estrogen inhibits hepatocellular carcinoma progression dependent on HOXA11-AS/HOXA11.
Zhou P, Sun F, Lin P, Yan Y, Liu J, Zhou Y, He T, Liu P, Wang J, Sun H, Ma H
Translational oncology 2025 Jul;57:102404
Translational oncology 2025 Jul;57:102404
Metformin Improves Palmitate-Induced Follicular Granulosa Cell Dysfunction by Activating ULK1-Mediated Autophagy.
Heng N, Hao H, Hu Y, Wang Y, Wang H, He W, Zhu N, Wang R, Xuan X, Zhu H, Zhao S, Wang F
Reproductive sciences (Thousand Oaks, Calif.) 2025 Jul;32(7):2442-2452
Reproductive sciences (Thousand Oaks, Calif.) 2025 Jul;32(7):2442-2452
Sevoflurane: A dual modulator of miR‑211‑5p and mitochondrial apoptosis in glioma therapy.
Wang H, Cheng G, Zhang S, Qu H, Zhao X, Yang A, Sun X, Pan H
Molecular medicine reports 2025 Jul;32(1)
Molecular medicine reports 2025 Jul;32(1)
Eburicoic acid inhibits endothelial cell pyroptosis and retards the development of atherosclerosis through the Keap1/Nrf2/HO‑1/ROS pathway.
Ma MQ, Yang C, Jin SY, Yang Y, Pan YY, Lin XH
Molecular medicine reports 2025 Jul;32(1)
Molecular medicine reports 2025 Jul;32(1)
LCMR1 deficiency exacerbates LPS‑induced lung injury in lung‑on‑a‑chip and mouse models.
Mo Z, Su C, Liu J, Ren J, Liu L, Wang Y, Li Y, Li C, Yang Z, Ma X, Chen L
Molecular medicine reports 2025 Jul;32(1)
Molecular medicine reports 2025 Jul;32(1)
UCP1 prevents the formation of thoracic aortic aneurysms and dissection by inhibiting the TLR4/NLRP3/IL-1β signaling pathway and VSMC phenotype switching in mice.
Xiang J, Yue H, Jiang D, Zheng S, Wu Z
Biochemical pharmacology 2025 Jul;237:116929
Biochemical pharmacology 2025 Jul;237:116929
Transglutaminase 2 promotes breast cancer cell autophagy by targeting p53/ mTOR axis.
Chen J, Li M, Mao J, Wang X, Guo B, Chen X, Kalvakolanu DV, Hong J, Yang M, Liu J, Luo Q, Yang J, Sun X, Tian Y, Zhang L
Biochemical pharmacology 2025 Jul;237:116926
Biochemical pharmacology 2025 Jul;237:116926
Discovery of a novel BCL-2 inhibitor GW806742X for the treatment of TNBC.
Liu W, Xu J, Chen L, Zhang D, Zhang J, Lu L, Zhang X, Huang X, Zhang G
Biochemical pharmacology 2025 Jul;237:116925
Biochemical pharmacology 2025 Jul;237:116925
ApTOLL ameliorates cognitive dysfunction and brain injury in ischemic stroke by regulating the miR-335-5p/IRAK1 axis.
Qin F, Feng X, Yang H, Liu H, Yuan W
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2025 Jul;22(4):e00573
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2025 Jul;22(4):e00573
Kit-mediated autophagy suppression driven by a viral oncoprotein emerges as a crucial survival mechanism in Merkel cell carcinoma.
Shi H, Yang Y, Gao J, Kumar S, Xie H, Chen Z, Lyu J, Sihto H, Koljonen V, Vega-Rubin-de-Celis S, Vukojevic V, Farnebo F, Björnhagen V, Höög A, Juhlin CC, Lee L, Wickström M, Becker JC, Johnsen JI, Larsson C, Lui WO
Autophagy 2025 Jul;21(7):1523-1543
Autophagy 2025 Jul;21(7):1523-1543
Design, synthesis, and antitumor activity of novel thioheterocyclic nucleoside derivatives by suppressing the c-MYC pathway.
Li XJ, Huang KX, Wang KX, Liu R, Wang DC, Liang YR, Hao EJ, Wang Y, Guo HM
Acta pharmaceutica Sinica. B 2025 Jul;15(7):3685-3707
Acta pharmaceutica Sinica. B 2025 Jul;15(7):3685-3707
Magnesium Lithospermate B Protects Against Ischemic AKI-to-CKD progression via regulating the KLF5/CDK1/Cyclin B1 pathway.
Lin L, Shen D, Su Y, Zhang Z, Yu J, Xu C, Pan K, Wang Y, Zhang L, Jin S, Song N, Ding X, Teng J, Xu X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul;142:156765
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul;142:156765
HOXD13 knockdown attenuates apoptosis in prostate cancer via the upregulation of MDM2/p53 signaling.
Ma Y, Qi P, Ren Z, Liu R, Wei S, Zhang A
Cell division 2025 Jul 6;20(1):18
Cell division 2025 Jul 6;20(1):18
Isoliensinine Induces Ferroptosis in Urothelial Carcinoma Cells via the PI3K/AKT/HIF-1α Axis: Molecular Evidence from Next-Generation Sequencing.
Li YC, Huang HE, Yu CY, Chang YC, Lin SY, Wang SC, Sung WW
Pharmaceuticals (Basel, Switzerland) 2025 Jul 6;18(7)
Pharmaceuticals (Basel, Switzerland) 2025 Jul 6;18(7)
Neferine induces cell growth inhibition and apoptosis via ROS-mediated activation of p38 in pancreatic ductal adenocarcinoma cells.
Zhou X, Chen M, Xing R, Yang F, Liu H, Liang S
Journal of molecular histology 2025 Jul 31;56(4):246
Journal of molecular histology 2025 Jul 31;56(4):246
EPHX1 enhances drug resistance to regorafenib by activating the JAK/STAT signaling pathway in hepatocellular carcinoma cell lines.
Xu B, Liang X, Liu W, Wu B, Wang Q, Kai G, Han C, Sun B, Dong B, Dong C, Wang L
Hereditas 2025 Jul 31;162(1):148
Hereditas 2025 Jul 31;162(1):148
Bovine lactoferrin drives cell cycle arrest and alters the transcriptomic profile of NSCLC cells.
Su J, Zhao Y, Li M, Chen G, Liu C, Idris A, Ma Z, Zhang H
Scientific reports 2025 Jul 30;15(1):27850
Scientific reports 2025 Jul 30;15(1):27850
Proteomics analysis reveals FEN1 as a promising therapeutic target against small cell neuroendocrine carcinoma of the cervix.
Liu J, Zhong M, Yang K, Wang J, Ma H, Wang W, Sun L, Liu L, Xu J, Cui X, Hao J, Li L
Scientific reports 2025 Jul 30;15(1):27827
Scientific reports 2025 Jul 30;15(1):27827
RhoJ promotes the progression of clear cell renal cell carcinoma via the TNF-α/NF-κB axis.
Feng J, Zheng B, Wang J, Xu Q, Ouyang Q, Li H, Jia T, Wang Y, Cai T, Feng Y, Zhang X, Li X, Ma X
Translational andrology and urology 2025 Jul 30;14(7):1849-1864
Translational andrology and urology 2025 Jul 30;14(7):1849-1864
Demethylzeylasteral suppresses the expression of MESP1 by reducing H3K18la level to inhibit the malignant behaviors of pancreatic cancer.
Ma X, Cheng M, Jia Y, Zhang K, Zhang H, Feng D, Xu W, Qiao G
Cell death discovery 2025 Jul 3;11(1):305
Cell death discovery 2025 Jul 3;11(1):305
Development of Antitumor Drugs Targeting c-MYC Pu27 and KRAS G-Quadruplexes.
Mohamed HI, Song Z, He Y, Gao C
Journal of medicinal chemistry 2025 Jul 24;68(14):14223-14238
Journal of medicinal chemistry 2025 Jul 24;68(14):14223-14238
Buzhong Yiqi decoction improves inflammation and oxidative damage in autoimmune thyroiditis by inhibiting apoptosis via the SIRT1-Mediated Nrf2/NF-κB axis.
Zhao Z, Li J, Song N, Gao H, Liu D, Jin Z, Chen Y, Guo X, Liu Z, Yang X
Journal of ethnopharmacology 2025 Jul 24;351:119967
Journal of ethnopharmacology 2025 Jul 24;351:119967
Synthetic oleanolic acid derivative, RTA-408, overcome in TMZ-resistant glioblastoma cells by inducing apoptosis and G1 cell cycle arrest.
Lee KT, Lieu AS, Lin CL, Hsu YC, Tsai TH
Medical oncology (Northwood, London, England) 2025 Jul 20;42(8):353
Medical oncology (Northwood, London, England) 2025 Jul 20;42(8):353
Identifying the crucial oncogenic mechanisms of DDX56 based on a machine learning-based integration model of RNA-binding proteins.
Jiang H, Zheng H, Zhao X, Xiang Y, Li J, Wang K, Wang G, Du J
NPJ precision oncology 2025 Jul 17;9(1):240
NPJ precision oncology 2025 Jul 17;9(1):240
Copper/calcium co-doped carbon dots for targeted cancer therapy with dual-mode imaging and synergistic induction of cuproptosis and calcium-mediated apoptosis.
Zheng W, Liu Y, Liu J, Zhao Y, Wang P, Wang Y, Wang Y, Lu Z, Liu X, Shi Y, Zhou N, González FE, Sun H, Zhou D, Xu X
Journal of colloid and interface science 2025 Jul 15;690:137337
Journal of colloid and interface science 2025 Jul 15;690:137337
Secreted phosphoprotein 1 promotes the activation of keloid fibroblasts via the CD44/TGF-β1/Smad pathway.
Tu Y, Xiong Y, Liu O, Peng Y
Experimental cell research 2025 Jul 15;450(2):114658
Experimental cell research 2025 Jul 15;450(2):114658
Integration of scRNA-seq and bulk tissue RNA-seq data to identify cancer-associated fibroblast-related gene RGMA as a potential treatment target for esophageal cancer.
Gao Y, Bao S, Wen B, Li H, Guo Q, Li A, Bao L, Li M, Han B
Functional & integrative genomics 2025 Jul 11;25(1):154
Functional & integrative genomics 2025 Jul 11;25(1):154
Tanshinone IIA induces oxidative stress in trophoblast cells and enhances copper dependent death.
Du J, Wang X, Zeng Y, Feng J, Yang L, Huang Y, Deng G
Scientific reports 2025 Jul 11;15(1):25012
Scientific reports 2025 Jul 11;15(1):25012
Biomimetic cancer cell membrane engineered lipid nanoparticles for enhanced chemotherapy of homologous malignant tumor.
Zhang F, Luo W, Min Z, Wu L, Wang Z, Wang Y, Liao W, Liu Y, Chen W, Wen L
BMC cancer 2025 Jul 1;25(1):1071
BMC cancer 2025 Jul 1;25(1):1071
Hsa_circ_0016662 acts as a prognostic biomarker and promotes the progression of hepatocellular carcinoma via autophagy regulation.
Deng G, He Y, Gan B, Liao C, Luo X, Zheng C, Mao L
Journal of translational medicine 2025 Jul 1;23(1):714
Journal of translational medicine 2025 Jul 1;23(1):714
Mitochondria-Targeted Microneedles Reverse Doxorubicin Resistance via Apoptosis-Ferroptosis Synergy.
Hao T, Guo H, Wang C, Jing S, Zhang W, Zeng Y, Hou J, Song Z, Li W
ACS nano 2025 Jul 1;19(25):23315-23333
ACS nano 2025 Jul 1;19(25):23315-23333
Dehydrocostus lactone suppresses gastric cancer progression by targeting ACLY to inhibit fatty acid synthesis and autophagic flux.
Chen Y, Shen J, Yuan M, Li H, Li Y, Zheng S, Han B, Zhang C, Liu S, Sun Q, Wu J
Journal of advanced research 2025 Jan;67:331-348
Journal of advanced research 2025 Jan;67:331-348
Revitalizing premature ovarian failure: quercetin counteracts imatinib-induced apoptosis via the PI3K/AKT signaling pathway based on network pharmacology.
Ji M, Weng S, Li X, Xiao Q, Tong Y, Zhou Y, Luo T, Liu Z
Naunyn-Schmiedeberg's archives of pharmacology 2025 Jan;398(1):833-842
Naunyn-Schmiedeberg's archives of pharmacology 2025 Jan;398(1):833-842
Indomethacin-encapsulated PLGA nanoparticles improve therapeutic efficacy by increasing apoptosis and reducing motility in glioblastoma cells.
Bostancı F, Şengelen A, Aksüt Y, Yıldırım E, Öğütcü İ, Yücel O, Emik S, Gürdağ G, Pekmez M
Pharmaceutical development and technology 2025 Jan;30(1):25-36
Pharmaceutical development and technology 2025 Jan;30(1):25-36
Diagnostic and prognostic potential of FBXO8 expression in kidney renal clear cell carcinoma and its regulation of renal adenocarcinoma cells.
Luo Z, Wu X, Xie J, Tang H, Chen J, Ye D, Dou S, Chen S
Cancer genetics 2025 Jan;290-291:6-15
Cancer genetics 2025 Jan;290-291:6-15
LINC00942 Alleviates NaAsO(2)-induced Apoptosis by Promoting GSH Synthesis Through Targeting miR-214-5p.
Ma M, Zhang J, Li S, Zhang M, Chen W, Li L, Li S
Biological trace element research 2025 Jan;203(1):167-177
Biological trace element research 2025 Jan;203(1):167-177
Unlocking the potential of LHPP: Inhibiting glioma growth and cell cycle via the MDM2/p53 pathway.
Guo L, Chen W, Yue J, Gao M, Zhang J, Huang Y, Xiong H, Li X, Wang Y, Yuan Y, Chen L, Fei F, Xu R
Biochimica et biophysica acta. Molecular basis of disease 2025 Jan;1871(1):167509
Biochimica et biophysica acta. Molecular basis of disease 2025 Jan;1871(1):167509
Inhibition of ACSS2 triggers glycolysis inhibition and nuclear translocation to activate SIRT1/ATG5/ATG2B deacetylation axis, promoting autophagy and reducing malignancy and chemoresistance in ovarian cancer.
Yang J, Wang H, Li B, Liu J, Zhang X, Wang Y, Peng J, Gao L, Wang X, Hu S, Zhang W, Hong L
Metabolism: clinical and experimental 2025 Jan;162:156041
Metabolism: clinical and experimental 2025 Jan;162:156041
HSP60 inhibits DF-1 apoptosis through its mitochondrial signal peptide.
Cao S, Li Y, Chen L, Lei X, Feng X, Li Y
Poultry science 2025 Jan;104(1):104571
Poultry science 2025 Jan;104(1):104571
Knockdown of integrin β1 inhibits proliferation and promotes apoptosis in bladder cancer cells.
Wang JF, Wang JS, Liu Y, Ji B, Ding BC, Wang YX, Ren MH
BioFactors (Oxford, England) 2025 Jan-Feb;51(1):e2150
BioFactors (Oxford, England) 2025 Jan-Feb;51(1):e2150
ONC213: a novel strategy to resensitize resistant AML cells to venetoclax through induction of mitochondrial stress.
Carter JL, Su Y, Al-Antary ET, Zhao J, Qiao X, Wang G, Edwards H, Polin L, Kushner J, Dzinic SH, White K, Buck SA, Hüttemann M, Allen JE, Prabhu VV, Yang J, Taub JW, Ge Y
Journal of experimental & clinical cancer research : CR 2025 Jan 9;44(1):10
Journal of experimental & clinical cancer research : CR 2025 Jan 9;44(1):10
Gboxin Induced Apoptosis and Ferroptosis of Cervical Cancer Cells by Promoting Autophagy-Mediated Inhibition of Nrf2 Signaling Under Low-Glucose Conditions.
Liu W, Lu J, Li J, Wang L, Chen Y, Wu Y, Zhang Z, Zhang J, Gao F, Jia C, Bao Y, Yang X, Song Z
International journal of molecular sciences 2025 Jan 9;26(2)
International journal of molecular sciences 2025 Jan 9;26(2)
CASP5 associated with PANoptosis promotes tumorigenesis and progression of clear cell renal cell carcinoma.
Yang K, Wang Y, Jian Y, Wang B, Du H, Xia Y, Bi J, Guo M, Li Z, Wang N
Cancer cell international 2025 Jan 8;25(1):8
Cancer cell international 2025 Jan 8;25(1):8
Ginkgo biloba extract mediates HT22 cell proliferation and migration after oxygen-glucose deprivation/reoxygenation via regulating RhoA-ROCK2 signalling pathway.
Wang D, Zhao X, Li J, Song Y, Chen W, Cai X, Liu R, Chen Z
Metabolic brain disease 2025 Jan 7;40(1):91
Metabolic brain disease 2025 Jan 7;40(1):91
Resveratrol Alleviates NEFA-Induced Oxidative Damage in Bovine Mammary Epithelial Cells by Restoring Mitochondrial Function.
Sun L, Huang J, Dou X, Dong Z, Li Y, Tan S, Yu R, Li C, Zhao W
Animals : an open access journal from MDPI 2025 Jan 7;15(2)
Animals : an open access journal from MDPI 2025 Jan 7;15(2)
Acrylamide Induces Antiapoptotic Autophagy and Apoptosis by Activating PERK Pathway in SH-SY5Y Cells.
Wang Y, Liu Y, Zhang X, Jiao Y, Duan L, Cheng R, Yang N, Yan H
Toxics 2025 Jan 7;13(1)
Toxics 2025 Jan 7;13(1)
Improving Targeted Delivery and Antitumor Efficacy of TRAIL through Fusion with a B7H3-Antagonistic Affibody.
Lu X, Zhan X, Xia G, Wang F, Lv M, Liu R, Liu Y, Zi C, Li G, Wang R, Li J, Yuan F, Jia D
Molecular pharmaceutics 2025 Jan 6;22(1):284-294
Molecular pharmaceutics 2025 Jan 6;22(1):284-294
Taraxasterol extracted from Ixeridium gramineum (Fisch.) Tzvel. Attenuated D-GalN/LPS-induced fulminant hepatitis by modulating the JAK/STAT and TNF signalling pathways.
Wang G, Yin Y, Lv R, Ling X, Cao H, Liu H, Wu J, Gao Y, Zhang K, Wang Y
Journal of ethnopharmacology 2025 Jan 31;340:119256
Journal of ethnopharmacology 2025 Jan 31;340:119256
A repeated strike loading organ culture model for studying compression-associated chronic disc degeneration.
Li B, Chen X, Chen H, Zhang F, Li J, Zhu Z, Tang T, Gao M, Li N, Ma L, Zhou Z
Biomolecules & biomedicine 2025 Jan 30;25(3):708-719
Biomolecules & biomedicine 2025 Jan 30;25(3):708-719
Identification of a novel TOP2B::AFF2 fusion gene in B-cell acute lymphoblastic leukemia.
Liu T, Wang Y, An XZ, Liu J, Wu Y, Xiang Y, Zhang YJ, Huang L, Li JC, Li YZ, Yu J
Scientific reports 2025 Jan 25;15(1):3280
Scientific reports 2025 Jan 25;15(1):3280
Discovery of a Potent and Selective GSPT1 Molecular Glue Degrader for the Treatment of Castration-Resistant Prostate Cancer.
Shen H, Xu H, Jin W, Wu T, Hu J, Zhang C, Zhong Z, Li J, Mao R, Zhang S, Zhang X, Wu X, Smaill JB, Xu J, Zhang Y, Xu Y
Journal of medicinal chemistry 2025 Jan 23;68(2):1553-1571
Journal of medicinal chemistry 2025 Jan 23;68(2):1553-1571
Extracellular Matrix-Mimicking Hydrogel with Angiogenic and Immunomodulatory Properties Accelerates Healing of Diabetic Wounds by Promoting Autophagy.
Pan Y, Li Y, Zhou X, Luo J, Ding Q, Pan R, Tian X
ACS applied materials & interfaces 2025 Jan 22;17(3):4608-4625
ACS applied materials & interfaces 2025 Jan 22;17(3):4608-4625
Citrinin-Induced Cellular Damage: Insights from SH-SY5Y Cell Line Studies.
Martí-Quijal FJ, Franco-Campos F, Barba FJ, Ruiz MJ
Foods (Basel, Switzerland) 2025 Jan 22;14(3)
Foods (Basel, Switzerland) 2025 Jan 22;14(3)
Stimulating Soluble Guanylyl Cyclase with the Clinical Agonist Riociguat Restrains the Development and Progression of Castration-Resistant Prostate Cancer.
Zhang L, Troccoli CI, Mateo-Victoriano B, Misiara Lincheta L, Jackson E, Shu P, Plastini T, Tao W, Kwon D, Chen XS, Sharma J, Jorda M, Kumar S, Lombard DB, Gulley JL, Bilusic M, Lockhart AC, Beuve A, Rai P
Cancer research 2025 Jan 2;85(1):134-153
Cancer research 2025 Jan 2;85(1):134-153
Quercetin Alleviates Hyperglycemic-Generated Endoplasmic Reticulum Stress-Contacted Apoptosis of Rat Nucleus Pulposus Cells.
Yu Z, Wang X, Hu Y, Wang X, Zhu Z, Xu X, Wang Y, Zhang A
Balkan medical journal 2025 Jan 2;42(1):27-36
Balkan medical journal 2025 Jan 2;42(1):27-36
Peroxiredoxin 6 maintains mitochondrial homeostasis and promotes tumor progression through ROS/JNK/p38 MAPK signaling pathway in multiple myeloma.
Gao D, Lv Y, Hong F, Wu D, Wang T, Gao G, Lin Z, Yang R, Hu J, He A, Zhang P
Scientific reports 2025 Jan 2;15(1):70
Scientific reports 2025 Jan 2;15(1):70
Hypoxia and lipid metabolism related genes drive proliferation migration and immune infiltration mechanisms in colorectal cancer subtyping.
Huang S, Wang H, Cao J, Pang Q
Scientific reports 2025 Jan 18;15(1):2394
Scientific reports 2025 Jan 18;15(1):2394
Heat Tolerance-Associated circRNA3685 Regulates Apoptosis and Autophagy in Bovine Mammary Epithelial Cells via Sponging bta-miR-138.
Zhang C, Hu L, Wang S, Chen G, Brito LF, Li B, Xu Q, Wang Y
Journal of agricultural and food chemistry 2025 Jan 15;73(2):1656-1671
Journal of agricultural and food chemistry 2025 Jan 15;73(2):1656-1671
Diisooctyl phthalate (DIOP) exposure leads to cell apoptosis to HUVEC cells and toxicity to Caenorhabditis elegans through increasing the oxidative stress.
Luo S, Li J, Zhou Y, Zhai Z, Li Q, Huang Z, He W, Zhong K, Kong B, Xia Z, Kwok HF, Zhu L
Ecotoxicology and environmental safety 2025 Jan 15;290:117594
Ecotoxicology and environmental safety 2025 Jan 15;290:117594
Discovery of a potent anticancer agent against pancreatic ductal adenocarcinoma targeting FAK with DFG-out state and JAK/Aurora kinases.
Zhang RH, Chen T, Xiong QQ, Wang S, Chen GQ, Zhang WL, Yuan HF, Zhao YL, Liu T, Huang Y, Zhou M, Yang CL, Liao SG, Li YJ
European journal of medicinal chemistry 2025 Jan 15;282:117059
European journal of medicinal chemistry 2025 Jan 15;282:117059
Molecule interacting with CasL-2 enhances tumor progression and alters radiosensitivity in cervical cancer.
Teng Y, Zhao H, Xue G, Zhang G, Huang Y, Guo W, Zou K, Zou L
Journal of translational medicine 2025 Jan 11;23(1):44
Journal of translational medicine 2025 Jan 11;23(1):44
Developmental exposure to perfluorooctane sulfonate(PFOS) impairs the endometrial receptivity.
Ren R, Zhou X, Jia T, Wang B, Liu A, Gao M, Song J, Wang L, Jing Y, Yu L, Shen H, Zhang X
Scientific reports 2025 Jan 11;15(1):1747
Scientific reports 2025 Jan 11;15(1):1747
Selenoprotein M protects cardiac endothelial cell integrity against high-glucose stress via enhancing Parkin-mediated mitophagy.
Zhao B, Tan WL, Yu BB, Fan J, Liu C, Liu J, Liu Z
Molecular and cellular endocrinology 2025 Jan 1;595:112392
Molecular and cellular endocrinology 2025 Jan 1;595:112392
Effects of PPARG on the proliferation, apoptosis, and estrogen secretion in goat granulosa cells.
Zhao J, Xu Y, Yu H, Li X, Wang W, Mao D
Theriogenology 2025 Jan 1;231:62-72
Theriogenology 2025 Jan 1;231:62-72
In vitro and in silico study of the synergistic anticancer effect of alpinumisoflavone with gemcitabine on pancreatic ductal adenocarcinoma through suppression of ribonucleotide reductase subunit-M1.
Lee W, Song G, Bae H
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2025 Jan 1;204:106969
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2025 Jan 1;204:106969
METTL5 Promotes Tumor Progression in Oral Squamous Cell Carcinoma by Activating the Myc Pathway.
Huang R, Feng X, Zhou T, Lu J, Wang Y, Zhang S, Zhang W
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2025 Feb;54(2):91-99
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2025 Feb;54(2):91-99
The role of TMEM163 protein in thyroid microcarcinoma: expression pattern and clinical implications.
Wang Y, Li J, Gao S, Dang D, Chen Y, Li Z, Yang H
Journal of endocrinological investigation 2025 Feb;48(2):303-315
Journal of endocrinological investigation 2025 Feb;48(2):303-315
High-intensity acute noise exposure causes anxiety in female rats by inducing hippocampal neuron apoptosis.
Song Y, Wang X, Zhang H, Ma R, Kang Y, Di X, Feng Z, Ni C, Zhao F, Zhuang H, Zhang J
Ecotoxicology and environmental safety 2025 Feb;291:117833
Ecotoxicology and environmental safety 2025 Feb;291:117833
Microplastic exposure induces HSP90α secretion and aggravates asthmatic airway remodeling via PI3K-Akt-mTOR pathway.
Xu M, Chen J, Gao L, Cai S, Dong H
Ecotoxicology and environmental safety 2025 Feb;291:117828
Ecotoxicology and environmental safety 2025 Feb;291:117828
oar-miR-411a-5p Promotes Proliferation and Differentiation in Hu Sheep Myoblasts Under Heat Stress by Targeting SMAD2.
Lu J, Liu Y, Li H
Journal of cellular physiology 2025 Feb;240(2):e31515
Journal of cellular physiology 2025 Feb;240(2):e31515
The effect and mechanism of atorvastatin regulating PI3K-Akt-mTOR pathway on radiosensitivity of hepatocellular carcinoma cells.
Deng Z, Guo J, Zhu Z, Qing Q, Wan D, Lei P, Liu Q, Huang B
Toxicology research 2025 Feb;14(1):tfae202
Toxicology research 2025 Feb;14(1):tfae202
Insulin-like growth factor-1 promotes the testicular sperm production by improving germ cell survival and proliferation in high-fat diet-treated male mice.
Liu G, Liu D, Zhu M, Zhang M, Li C, Xu X, Pan F
Andrology 2025 Feb;13(2):342-358
Andrology 2025 Feb;13(2):342-358
In Situ Transformable Nanoparticle Effectively Suppresses Bladder Cancer by Damaging Mitochondria and Blocking Mitochondrial Autophagy Flux.
Lv Y, Song B, Yang G, Wang Y, Wu Z, Si M, Yang Z, Chen H, Liu C, Li M, Zhang Y, Qiao Z, Wang L, Xu W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(5):e2409425
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(5):e2409425
Integrated multiomics approach and pathological analyses provide new insights into hepatic injury and metabolic alterations in Saanen goats after dietary exposure to aflatoxin B(1).
Su D, Peng J, Hao J, Wang X, Yu P, Li S, Shi H
Journal of dairy science 2025 Feb;108(2):1431-1450
Journal of dairy science 2025 Feb;108(2):1431-1450
Design and Synthesis of Novel MEK Inhibitors for the Treatment of Solid Tumors.
Zeng J, Luo Z, Zhao T, Xia C, Liu F, Li N, Qu L, Wang C
Chemical biology & drug design 2025 Feb;105(2):e70067
Chemical biology & drug design 2025 Feb;105(2):e70067
Therapeutic effect of dihydroartemisinin on Alzheimer's disease model mice with senile macular degeneration.
Han G, Xuewu G, Meng Z, Yuejing W, Yuchun W, Keshuang Z, Hongbo Y
European journal of medical research 2025 Feb 5;30(1):81
European journal of medical research 2025 Feb 5;30(1):81
ARv7 promotes the escape of prostate cancer cells from androgen deprivation therapy-induced senescence by mediating the SKP2/p27 axis.
Zhuang D, Kang J, Luo H, Tian Y, Liu X, Shao C
BMC biology 2025 Feb 28;23(1):66
BMC biology 2025 Feb 28;23(1):66
The Natural Antherea pernyi Sericin Protein Suppresses Gastric Cancer Formation by Inhibiting Cell Proliferation and Inducing Cell Apoptosis.
Wei QQ, Xiao Y, Wu Q, Jing C, Dong ZQ, Chen P, Pan MH
International journal of molecular sciences 2025 Feb 22;26(5)
International journal of molecular sciences 2025 Feb 22;26(5)
Trillin inhibits MAP3K11/NF-κB/COX-2 signaling pathways through upregulation of miR-145-5p in castration-resistant prostate cancer.
Wang Y, Peng Y, Hao W, He C, Gao X, Liang P, Zhao H, Wang Y, Wang L, Yu Z, Liu Z
iScience 2025 Feb 21;28(2):111505
iScience 2025 Feb 21;28(2):111505
Anti-osteosarcoma activity of Corynoline via Src/JNK signaling-mediated cell cycle arrest and mitochondrial apoptosis.
Li M, Jiao J, Jiang W, Yu T, Wang Y, Wang Z, Wu M
International immunopharmacology 2025 Feb 20;148:114126
International immunopharmacology 2025 Feb 20;148:114126
Huqi formula suppresses hepatocellular carcinoma growth by modulating the PI3K/AKT/mTOR pathway and promoting T cell infiltration.
Yin D, Li X, Yang X, Shang X, Li Z, Geng J, Xu Y, Xu Z, Wang Z, Shang Z, Yang Z, Hu L, Li Q, Wang J, Song X, Li X, Wang X
Chinese medicine 2025 Feb 19;20(1):25
Chinese medicine 2025 Feb 19;20(1):25
Metformin inhibits the growth of SCLC cells by inducing autophagy and apoptosis via the suppression of EGFR and AKT signalling.
Xia H, Tai XJ, Cheng W, Wu Y, He D, Wang LF, Liu H, Zhang SY, Sun YT, Liu HZ, Liu DD, Zhao HZ, Ji FY, Li XH
Scientific reports 2025 Feb 19;15(1):6081
Scientific reports 2025 Feb 19;15(1):6081
Dihydroartemisinin inhibits EphA2/PI3K/Akt pathway-mediated malignant behaviors and vasculogenic mimicry in glioma stem cells.
Fu H, Wu S, Shen H, Luo K, Huang Z, Lu N, Li Y, Lan Q, Xian Y
Heliyon 2025 Feb 15;11(3):e42095
Heliyon 2025 Feb 15;11(3):e42095
Periplaneta americana Extract Protects Glutamate-Induced Nerve Cell Damage by Inhibiting N-Methyl-D-Aspartate Receptor Activation.
Zhou Y, Yang X, Hong C, Guan T, Xiao P, Yang Y, Zhang C, He Z
Biology 2025 Feb 13;14(2)
Biology 2025 Feb 13;14(2)
Bisdemethoxycurcumin and Curcumin Alleviate Inflammatory Bowel Disease by Maintaining Intestinal Epithelial Integrity and Regulating Gut Microbiota in Mice.
Hsu KY, Majeed A, Ho CT, Pan MH
Journal of agricultural and food chemistry 2025 Feb 12;73(6):3494-3506
Journal of agricultural and food chemistry 2025 Feb 12;73(6):3494-3506
Inhibition Effects and Mechanism Study of rAj-HRP30, a Recombinant Histidine-Rich Peptide from Apostichopus japonicus, on the Viability of Pancreatic Ductal Adenocarcinoma Cells Panc01 and Panc02.
Song Y, Gao S, Jiang J, Zhang Y, Zhang J, Wang X, Lv L, Zhou Z, Wang J
International journal of molecular sciences 2025 Feb 11;26(4)
International journal of molecular sciences 2025 Feb 11;26(4)
Multi-omics analysis reveals the impact of YAP/TEAD4-mediated EIF5A1 expression on mitochondrial apoptosis and bladder cancer progression.
Li KP, Wan S, Wang CY, Chen SY, Wang L, Liu SH, Yang L
BMC cancer 2025 Feb 11;25(1):234
BMC cancer 2025 Feb 11;25(1):234
Berberine attenuates obesity-induced skeletal muscle atrophy via regulation of FUNDC1 in skeletal muscle of mice.
Wu Y, Yang Y, Du C, Peng X, Fan W, Chang B, Shan C
Scientific reports 2025 Feb 10;15(1):4918
Scientific reports 2025 Feb 10;15(1):4918
Cadmium-Induced Kidney Apoptosis Based on the IRE1α-XBP1 Signaling Pathway and the Protective Effect of Quercetin.
Wang L, Cao W, Wu T
Toxics 2025 Feb 10;13(2)
Toxics 2025 Feb 10;13(2)
Low shear stress induces vascular endothelial cells apoptosis via miR-330 /SOD2 /HSP70 signaling pathway.
Li K, Wang S, Li J, Wang L, Zhang Q, Hou L, Yu X, Liu Z, Lv T, Shang L
Experimental cell research 2025 Feb 1;445(1):114410
Experimental cell research 2025 Feb 1;445(1):114410
Simultaneously delivery of functional gallium ions and hydrogen sulfide to endow potentiated treatment efficacy in chemo- and PARPi-resistant ovarian cancer.
Tang S, Li Y, Fang Y, Tu M, Wu S, Cen Y, Xu J
Journal of nanobiotechnology 2025 Feb 1;23(1):73
Journal of nanobiotechnology 2025 Feb 1;23(1):73
Plasma-activated solutions prevent peritoneal adhesion formation by regulating eNOS expression in mesothelial cells.
Ma Y, Sun T, Ren K, Ma R, Min T, Wang X, Yuan Y, Xie X, Zhang B, Deng X, Peng Y, Liu Y, Nan Y, Wang W, Zhou Z, Xu G, Li K, Zhu K, Hao N, Dang C, Zhang G, Zhang H
Journal of advanced research 2025 Dec;78:555-571
Journal of advanced research 2025 Dec;78:555-571
Cancer-associated fibroblast-derived extracellular vesicles regulate lipophagy through PLIN2 to modulate dormancy in salivary gland adenoid cystic carcinoma cells.
Dou Z, Zhang X, Meng K, Li M, Pang X, Wang W, Shi R, Liang X, Tang Y
Experimental & molecular medicine 2025 Dec;57(12):2852-2868
Experimental & molecular medicine 2025 Dec;57(12):2852-2868
Corticotropin-releasing hormone inhibits autophagy by suppressing PTEN to promote apoptosis in dermal papilla cells.
Liang W, Chen X, Ni N, Zhuang C, Yu Z, Xu Z, Li Y, Lin C, Huang K
Annals of medicine 2025 Dec;57(1):2490823
Annals of medicine 2025 Dec;57(1):2490823
Unraveling the miR-144-3p/PUMA pathway: a novel regulator of FDX1-mediated cuproptosis in colorectal cancer.
Jia G, Li J, Jiang M, Liu N, Ding N, Jiang X, Zhang G, Tan X, Kang Y, Zhang L, Wang F, Zhang Y
Cellular oncology (Dordrecht, Netherlands) 2025 Dec;48(6):1693-1710
Cellular oncology (Dordrecht, Netherlands) 2025 Dec;48(6):1693-1710
TM4SF1 as a Prognostic Biomarker and Therapeutic Target in Cervical Cancer.
Deng JX, Zhang LY, Ouyang ZQ, Guo T, Shen FJ, Zheng HY
Current medical science 2025 Dec;45(6):1367-1381
Current medical science 2025 Dec;45(6):1367-1381
Design, synthesis, and bioevaluation of pyrazole-containing tubulin polymerisation inhibitors based on conformational constraint strategy.
Sun Z, Wang J, Li F, Huang L, Zheng S, Guan Q, Wang Z, Zhang W
Journal of enzyme inhibition and medicinal chemistry 2025 Dec;40(1):2545004
Journal of enzyme inhibition and medicinal chemistry 2025 Dec;40(1):2545004
Pan-cancer analysis identifies adhesion G protein-coupled receptor G6 as a potential prognostic and immunotherapeutic biomarker with its functional validation.
Zhu J, Wang Y, Huang Q, Liu Z
International journal of biological macromolecules 2025 Dec;334(Pt 2):149128
International journal of biological macromolecules 2025 Dec;334(Pt 2):149128
Bovine tubulin cofactor D (TBCD) disrupts tubulin dimers and inhibits tumor growth via the TNF-α signaling pathways-mediated ROS production.
Wang H, Guo J, Yang J, Wu X, Wu F, Wu H, Zhan Y, Zhang H
International journal of biological macromolecules 2025 Dec;334(Pt 1):148987
International journal of biological macromolecules 2025 Dec;334(Pt 1):148987
CD44 and αV-integrins dual-targeting bimetallic nanozymes for lung adenocarcinoma therapy via NIR-enhanced ferroptosis/apoptosis.
He J, Li T, Pan X, Deng Z, Huang J, Mo X, Shen X, Qin X, Yang X, Gao M, Yang J
Biomaterials 2025 Dec;323:123407
Biomaterials 2025 Dec;323:123407
The novel thioredoxin reductase inhibitor butaselen suppresses lung cancer by inducing oxidative stress.
Chen Y, Qiang G, Jin L, Sun Y, Zhang G, Hu F, Feng J, Wei F, Zeng S, Xue L, Zeng H, Ma S
Redox report : communications in free radical research 2025 Dec;30(1):2588086
Redox report : communications in free radical research 2025 Dec;30(1):2588086
Flavonoids from Polypodium hastatum as neuroprotective agents attenuate cerebral ischemia/reperfusion injury in vitro and in vivo via activating Nrf2.
Yao H, Wu R, Du D, Ai F, Yang F, Li Y, Qi S
Redox report : communications in free radical research 2025 Dec;30(1):2440204
Redox report : communications in free radical research 2025 Dec;30(1):2440204
Knockdown of NDUFAF6 inhibits breast cancer progression via promoting mitophagy and apoptosis.
Wu S, Ma X, Zhang X, Du K, Shi C, Almaamari AA, Han B, Su S, Liu Y
Cancer biology & therapy 2025 Dec;26(1):2445220
Cancer biology & therapy 2025 Dec;26(1):2445220
Juglone targets MMP-1 to inhibit gastric cancer progression.
Zhou F, Xie Y, Li X, Peng P
Biochemical pharmacology 2025 Dec;242(Pt 2):117289
Biochemical pharmacology 2025 Dec;242(Pt 2):117289
Appropriate doses of ionizing radiation facilitate the proliferation and anti-tumor effects of γδ T cells through ERK and p38MAPK pathways in vitro.
Wang LL, Yang Y, Feng YB, Zhao HQ, Hong Q, Chen FX, Chen L, Sun LQ, Lü XT, Sun F, Feng H, Chen K, Liu ZH, Guo LL, Zhou ZH
Molecular immunology 2025 Dec;188:80-88
Molecular immunology 2025 Dec;188:80-88
YAP regulates the hypertrophy and apoptosis of antler chondrocytes through maintaining calcium homeostasis and mitochondrial function.
Li BY, Yang ZQ, Xing YF, Zhang QL, Wang CH, Yue ZP, Guo B
Cellular signalling 2025 Dec;136:112137
Cellular signalling 2025 Dec;136:112137
Puerarin alleviates liver injury induced by heat-stress through regulating oxidative stress and apoptosis in broilers.
Xu G, Ma F, Li Y, Miao J, Zhang X, Xiong Y, He S
Journal of thermal biology 2025 Dec;134:104317
Journal of thermal biology 2025 Dec;134:104317
Skullcapflavone II Inhibits SLC1A4-Mediated L-Serine Uptake and Promotes Mitochondrial Damage in Gastric Cancer.
Zhao J, Ma YB, Xia RH, Jiang ZC, Zhou Y, Wang YN, Yang MY, Dai JJ, Zhu T, Pan LB, Yuan L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(45):e17225
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(45):e17225
Kaempferol exerts anti-colorectal cancer effects through its multi-target mediated glucose metabolism remodeling.
Wu H, Guo Z, Hu P, Du J, Wang P, Ma J, Zhao B, Wei J, Li Z
Food & function 2025 Dec 8;16(24):9593-9608
Food & function 2025 Dec 8;16(24):9593-9608
Neuroprotective peptide OL-FS13 attenuates cardiac apoptosis and myocardial infarction injury through Nrf2/HO-1 pathway.
Wang H, Zhou K, Chen X, Tong Y, Jiang Q, She Q, Xiao J
Clinical and experimental hypertension (New York, N.Y. : 1993) 2025 Dec 31;47(1):2556422
Clinical and experimental hypertension (New York, N.Y. : 1993) 2025 Dec 31;47(1):2556422
RSL3 Mitigates Doxorubicin Resistance in Breast Cancer via Targeted Disruption of Glycolytic Flux.
Li M, Wang X, Hong J, Guan X, Chen Y, Zhou H, Wang X, Liang B, Gao X, Wu Y, Song D
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Dec 31;39(24):e71369
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Dec 31;39(24):e71369
Albiflorin enhances the antitumor effects of propofol in hepatocellular carcinoma cells by inhibiting the Wnt/β-catenin signaling activation.
Ji T, Ye L, Xu C, Ma C, Yin G
Translational cancer research 2025 Dec 31;14(12):8875-8888
Translational cancer research 2025 Dec 31;14(12):8875-8888
Erzhi Tiangui formula increases the number of high-quality blastocysts in patients with advanced age by regulating the Nrf2/HO-1 signaling pathway: a randomized controlled study.
Xiufang L, Zhongqing W, Huidan W, Ye Z, Xu H, Wei C, Haicui W, Fang L
Journal of ovarian research 2025 Dec 30;19(1):37
Journal of ovarian research 2025 Dec 30;19(1):37
The Role of Chaf1b in Maintaining Glioma Stem Cell Stemness and Regulating Microglial Polarization.
He YL, Niu L, Wang C, Liao ZP, Liu K, Gao S, Du AC, Liu WG, Jia J, Zhang YB, Yin H, Yuan GQ, Pan YW
The Journal of neuroscience : the official journal of the Society for Neuroscience 2025 Dec 3;45(49)
The Journal of neuroscience : the official journal of the Society for Neuroscience 2025 Dec 3;45(49)
TRIM47-facilitated PLK1 stabilization promotes the proliferation of liver cancer cells.
Xie T, Fan X, Yu T, Zhu Q, Zhang Q, Li N, Wang T, Qian Y, Deng K, Xin H, Li Y, Huang X
Cellular oncology (Dordrecht, Netherlands) 2025 Dec 29;49(1):7
Cellular oncology (Dordrecht, Netherlands) 2025 Dec 29;49(1):7
Hypoxic preconditioned mesenchymal stem cell-derived exosomes alleviate oxidative stress-induced cardiomyocyte apoptosis through miR-486-5p.
Zeng ZF, Rao J, Xia XB, Chen XY, He HX, Liu B, Chen Q, Liu YD, Wang GJ, Cheng PC, Wang JN, Wang P, Yu Y, Wang ZN
World journal of stem cells 2025 Dec 26;17(12):112207
World journal of stem cells 2025 Dec 26;17(12):112207
Cyclophilin D suppresses colorectal cancer progression through the activation of an autophagy-mediated apoptotic pathway.
Zhang L, Liu Y, Liu R, Wang W, Li R
Scientific reports 2025 Dec 26;16(1):3723
Scientific reports 2025 Dec 26;16(1):3723
Shikonin inhibits multiple tumor malignant phenotypes and is associated with Hedgehog pathway downregulation in lung adenocarcinoma.
Wang HG, Lu MX, Sheng ML, Lou YB, Xiao YC, Guo A, Yu ZH
Scientific reports 2025 Dec 24;15(1):44516
Scientific reports 2025 Dec 24;15(1):44516
RNF152-mediated, ubiquitin-dependent degradation of HSP27 activates the PI3K/AKT pathway, driving synovial inflammatory cascades in TMJOA.
Zhang X, Jiang Q, Deng W, Tang H, Liu Y, Xu Z, Guo K, Liu N, Wang H, Cui T, Wang F, Qiu J
Arthritis research & therapy 2025 Dec 18;28(1):16
Arthritis research & therapy 2025 Dec 18;28(1):16
A Scorpion Peptide Exerts Selective Anti-Leukemia Effects Through Disrupting Cell Membranes and Triggering Bax/Bcl-2-Related Apoptosis Pathway.
Dong X, Yi S, Yang Y, Wang Y, Wang L, Huang J, Zeng Y, Liu Z
Biomolecules 2025 Dec 18;15(12)
Biomolecules 2025 Dec 18;15(12)
Hedyotis diffusae herba -Scutellaria Barbata herba drug pair suppresses prostate cancer by inducing apoptosis.
Qiu J, Wu L, Hong Z, Shi Y, Wei Y, Wang Q, Chen Z, Chen W, Zhang Q, You XJ, Zhou WB, Zhou W
Scientific reports 2025 Dec 17;16(1):2938
Scientific reports 2025 Dec 17;16(1):2938
Triptolide combined with arsenic trioxide induces apoptosis of myelodysplastic syndrome cells by inhibiting the NF-κB signaling pathway.
Sheng L, Zhu Y, Wen Z, Fang M, Gu S, Ye L, Hua H
Medicine 2025 Dec 12;104(50):e46206
Medicine 2025 Dec 12;104(50):e46206
Resveratrol Derivatives with a Urea Backbone Exert Anticancer Effects against Liver Cancer via Apoptosis Induction and Metastasis Inhibition.
Hua W, Cheng Y, Li F, Li Y, Lu Z, Li L, Wang D, Liu J
Journal of agricultural and food chemistry 2025 Dec 10;73(49):31429-31443
Journal of agricultural and food chemistry 2025 Dec 10;73(49):31429-31443
NSUN2 Negatively Regulates TP53 mRNA Stability to Promote the Malignant Progression of Nasopharyngeal Carcinoma.
Zheng L, Wei J, Li X, Li M, Xue C, Chen S, Wei Q, Fan S, Xiong W, Zhou M, Deng H
Cancers 2025 Dec 10;17(24)
Cancers 2025 Dec 10;17(24)
CD36-mediated fatty acid metabolic reprogramming activates synovial fibroblasts and promotes rheumatoid arthritis progression.
Hao J, Zheng J, Liu C, Lu J, Tan M, Li J, Mao J, Yu Y, Wang H, Zhang Y, Shen H
International immunopharmacology 2025 Dec 10;167:115594
International immunopharmacology 2025 Dec 10;167:115594
Liproxstatin-1 Protects SH-SY5Y Cells by Inhibiting H(2)O(2)-Induced Excessive Mitophagy and Apoptosis.
Yan T, Ding F, Fang Z, Zhao Y
International journal of molecular sciences 2025 Dec 1;26(23)
International journal of molecular sciences 2025 Dec 1;26(23)
Epimedokoreanin B blocks autophagic flux to inhibit progression of triple negative breast cancer through targeting MCOLN1/TRPML1 channel.
Zhao C, Zhang P, Yang X, Liu M, Guan Z, Ma B, Duan X, Su C
Free radical biology & medicine 2025 Dec 1;240:222-237
Free radical biology & medicine 2025 Dec 1;240:222-237
Gamma-aminobutyric acid-B receptor axis promotes proliferation and survival of multiple myeloma cells via enhancing ERK1/2 activity.
Hu W, Zhang C, He F, Zhao H, Peng L, Gao R, Lu M, Cheng Y, Yu L, Tian J, Zhou Y, Wen F, Cao Y, Huang J, Zeng X, Xia J
Journal of leukocyte biology 2025 Dec 1;117(12)
Journal of leukocyte biology 2025 Dec 1;117(12)
Mechanism of lncRNA WARS2-IT1 promoting angiogenesis of glioma through miR-299-3P/VEGFA axis and activating PI3K/AKT signaling pathway.
Hu M, Gu W, Huai Y, Wang C, Mei J
Cytotechnology 2025 Aug;77(4):157
Cytotechnology 2025 Aug;77(4):157
Integrated stress response activation induced by usnic acid alleviates BCL-2 inhibitor ABT-199 resistance in acute myeloid leukemia.
Wu D, Li M, Hong Y, Jin L, Liu Q, Sun C, Li L, Han X, Deng S, Feng Y, Shen Y, Kai G
Journal of advanced research 2025 Aug;74:621-635
Journal of advanced research 2025 Aug;74:621-635
cPDS Promotes Cell Apoptosis by Reducing the Translational Efficiency of BIRC3 mRNA in HCC.
Liu Y, Liu Q, Huang T, Zhang S, Zhou Z, Gu C, Lu C
Digestive diseases and sciences 2025 Aug;70(8):2706-2718
Digestive diseases and sciences 2025 Aug;70(8):2706-2718
P5CS deacetylation mediated by SIRT2 facilitates tumor growth by enhancing mitochondrial respiration in hepatocellular carcinoma.
Geng X, Li M, Zhang L, Cai Y, Chen X, Mu X, Wang J, Liu B
Oncogene 2025 Aug;44(31):2746-2761
Oncogene 2025 Aug;44(31):2746-2761
Dominant follicle-targeted nanocarriers for GH delivery to alleviate premature ovarian insufficiency.
Yang S, Sun Y, Luo W, Zhou X, Gu X, Zhang W, Zhu H, Wu W, Wu X, Yu M, Wang S
Materials today. Bio 2025 Aug;33:101930
Materials today. Bio 2025 Aug;33:101930
A novel variant in the MAP3K1 genomic locus reveals abnormal cell apoptosis as a potential pathogenic mechanism in 46, XY disorders of sex development.
Lu Y, Wei S, Wang S, Zhang J, Xu Y, Huang C, Pan W, Wang Z
Molecular medicine reports 2025 Aug;32(2)
Molecular medicine reports 2025 Aug;32(2)
circGAPVD1 inhibits the progression of gastric cancer through miR-4424/STK4 axis and encoding GAPVD1-137aa protein.
Zhu L, Yao Z, Liu Y, Shao S, Zhou W, Ding J, Mao B, Shao C, Cui F
International journal of biological macromolecules 2025 Aug;319(Pt 3):145408
International journal of biological macromolecules 2025 Aug;319(Pt 3):145408
Zn(2+)-driven metformin conjugated with siRNA attenuates osteoarthritis progression by inhibiting NF-κB signaling and activating autophagy.
He H, Huang C, Huang H, Lan N, Liu S, Luo Y, Zheng L, Liu G, Qin Z, Zhao J
Biomaterials 2025 Aug;319:123210
Biomaterials 2025 Aug;319:123210
Silencing PIM1 inhibits ENO1-induced AKT activation and attenuates fibrillogenesis during spinal cord injury-induced skeletal muscle atrophy.
Yu X, Cao J, Wang B, Fu J, Liu J, Sui T, Wang Z, Wu C, Chang J, Cao X, Zhang S
The Journal of biological chemistry 2025 Aug;301(8):110398
The Journal of biological chemistry 2025 Aug;301(8):110398
Melatonin Synergises the Chemotherapeutic Effect of Temozolomide in Glioblastoma by Suppressing NF-κB/COX-2 Signalling Pathways.
Tang H, Dai Q, Zhao Z, Ge W, Li D, Chang Z, Pi P, Li J, Sun Z
Journal of cellular and molecular medicine 2025 Aug;29(15):e70778
Journal of cellular and molecular medicine 2025 Aug;29(15):e70778
TNFSF14-HVEM/LTβR Exacerbates Keratinocyte Abnormalities and IMQ-Induced Psoriatic Skin Inflammation via Activating NF-κB/TWIST1 Signalling Pathway.
Long SJ, Zheng QY, Xu F, Li GQ, Chen J, Chen WJ, Xu JM, Gao XL, Liang SJ, Xu GL
Journal of cellular and molecular medicine 2025 Aug;29(15):e70774
Journal of cellular and molecular medicine 2025 Aug;29(15):e70774
PIMREG modulation of PI3K/Akt pathway enhances sorafenib resistance in Huh7 cells.
Zhang L, Gao A, Peng K
Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology 2025 Aug;26(3):241-249
Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology 2025 Aug;26(3):241-249
miR-128-3p Reduces Proliferation and Immune Escape in Acute Myeloid Leukemia Through Targeted Regulation of ZEB1.
Zhang Y, Ma D, Zhang X, Chen W, Wang X, Sun R, Li K
Applied biochemistry and biotechnology 2025 Aug;197(8):4999-5016
Applied biochemistry and biotechnology 2025 Aug;197(8):4999-5016
Mechanism of sulforaphane in treatment of pancreatic cancer cell based on network pharmacology and in vitro experiments.
Ren Z, Feng J, Yang M, Feng D, Wang X, Liu W
Bioorganic chemistry 2025 Aug;163:108754
Bioorganic chemistry 2025 Aug;163:108754
Gracillin induces mitochondria-mediated apoptosis on pancreatic ductal adenocarcinoma through disruption of redox homeostasis via inhibiting NRF2/HO-1 antioxidant axis.
Lee W, Song G, Bae H
Bioorganic chemistry 2025 Aug;163:108636
Bioorganic chemistry 2025 Aug;163:108636
Inhibitory effect of SMAD2 on myogenesis in heat-stressed Hu sheep myoblasts.
Lu J, Liu Y, Li H
Journal of thermal biology 2025 Aug;132:104223
Journal of thermal biology 2025 Aug;132:104223
Lobaric Acid Exhibits Anticancer Potential by Modulating the Wnt/β-Catenin Signaling Pathway in MCF-7 Cells.
Kalın ŞN, Bayındırlı KN, Toraman E, Günaydın Ş, Keleş F, Altay A, Budak H
Pharmacology research & perspectives 2025 Aug;13(4):e70142
Pharmacology research & perspectives 2025 Aug;13(4):e70142
Melatonin mitigates arsenic and fluoride-induced cardiotoxicity in chickens by maintaining mitochondrial homeostasis.
Yuan X, Wen B, Hu X, Yang M, Han L, Zhao S, Zhang J, Ma Y
Poultry science 2025 Aug;104(8):105325
Poultry science 2025 Aug;104(8):105325
The functional role of exosomal miRNA-675-3p derived from patients with hepatocellular carcinoma.
Liang C, Ji X, Liu S, Xu L, Xiong Y, Cao G
Translational cancer research 2025 Aug 31;14(8):5012-5027
Translational cancer research 2025 Aug 31;14(8):5012-5027
Non-SMC condensin I complex subunit H promotes cell proliferation and inhibits cell apoptosis of clear cell renal cell carcinoma by activating the PI3K/AKT pathway.
Ha H, Wang J, Zhang X, Du Y, Xiong W, Li S, Shang P
Translational andrology and urology 2025 Aug 30;14(8):2153-2170
Translational andrology and urology 2025 Aug 30;14(8):2153-2170
TRIM2 inhibits apoptosis by ubiquitinating BNIP3 to protect the intestine against ischemia-reperfusion injury in mice.
Nie J, Mei C, Wei A, Wang Y, Fan C, Huang Y, Jiang M, Che H, Chen T, Tian J, Li Y, Huang X, Zhang X
Communications biology 2025 Aug 29;8(1):1308
Communications biology 2025 Aug 29;8(1):1308
Integrated network pharmacology and metabolomics to explore the mechanism of Kadsura coccinea root in alleviating acetaminophen-induced liver injury.
Wang YS, Liu SQ, Yao YX, Zhang S, Li DH, Li HY, Yu HH, Yuan HW, Wang W, Li B, Yang YP
Journal of ethnopharmacology 2025 Aug 29;352:120278
Journal of ethnopharmacology 2025 Aug 29;352:120278
Mechanisms and synergistic effects of the active components of Xanthocerais lignum in inhibiting rheumatoid arthritis through the modulation of the biological behavior of synovial cells.
Qian H, Bai C, Jia X, Yang Y, Tian X, Wang X
Journal of ethnopharmacology 2025 Aug 29;352:120200
Journal of ethnopharmacology 2025 Aug 29;352:120200
TGF-β-Enriched Exosomes from Acute Myeloid Leukemia Activate Smad2/3-MMP2 and ERK1/2 Signaling to Promote Leukemic Cell Proliferation, Migration, and Immune Modulation.
Jia J
Current issues in molecular biology 2025 Aug 27;47(9)
Current issues in molecular biology 2025 Aug 27;47(9)
Vinburnine potentiates anti-PD1 immunotherapy in melanoma through IL-24 secretion via P38/MAPK/ATF3 signaling.
Zhu S, Zhang X, Liu W, Zhou Z, Xiong S, Chen X, Peng C
Journal of experimental & clinical cancer research : CR 2025 Aug 27;44(1):255
Journal of experimental & clinical cancer research : CR 2025 Aug 27;44(1):255
The study of JAZF1-mediated apoptosis of decidual stromal cells by activating the NF-κB signaling pathway in spontaneous preterm birth.
Gong MQ, Hu YY, Zhang YQ, Wang XD
BMC pregnancy and childbirth 2025 Aug 27;25(1):891
BMC pregnancy and childbirth 2025 Aug 27;25(1):891
Spautin-1 inhibits the growth of diffuse large B-cell lymphoma by inducing mitochondrial damage-mediated PANoptosis and anti-tumor immunity.
Wu J, Deng Y, Gao Y, Wei B
Cancer immunology, immunotherapy : CII 2025 Aug 25;74(9):293
Cancer immunology, immunotherapy : CII 2025 Aug 25;74(9):293
PP2A attenuates α-amanitin-induced liver injury by promoting autophagy and inhibiting apoptosis in mouse models.
Xu H, Sun J, Zhao Y, Zhou Y, Wang K, Liu X, Yang J, Wu P, Wang S, Kastelic JP, Qu W, Zhang L, Gu X
Chemico-biological interactions 2025 Aug 25;417:111558
Chemico-biological interactions 2025 Aug 25;417:111558
MRPL13 enhances mitochondrial function and promotes tumor progression in ovarian cancer by inhibiting mPTP opening via SLC25A6.
Liu O, Hu Y, Wang S, Nie X, Wang Y, Fan X, Zeng K, Li X, Liu B, Lin B
Cell death & disease 2025 Aug 21;16(1):634
Cell death & disease 2025 Aug 21;16(1):634
Isorhamnetin protects against D-GalN/LPS-induced acute liver injury in mice through anti-oxidative stress, anti-inflammation, and anti-apoptosis.
Long L, Zhang M, Qin HZ, Xu LB, Wang BB, Wu WY, Zhu H, Lin S
BMC complementary medicine and therapies 2025 Aug 2;25(1):297
BMC complementary medicine and therapies 2025 Aug 2;25(1):297
Targeting ATF4-DDIT4/TXNIP induced mitochondrial dysfunction and ferroptosis: ISRIB as novel therapy for septic cardiomyopathy.
Chen Y, Feng X, Li Z, Wang X, Xiong W, Liu J, Wang G, Xu W, Jin R, Zhang L, Qian Z
Journal of translational medicine 2025 Aug 19;23(1):938
Journal of translational medicine 2025 Aug 19;23(1):938
Oxypalmatine promotes apoptosis and protective autophagy in lung cancer cells via the PI3K/AKT pathway.
Qiao G, Huang Z, Zhou Y, Shi J
Cancer cell international 2025 Aug 18;25(1):307
Cancer cell international 2025 Aug 18;25(1):307
Development of Hydrogen Sulfide-Donating Silybin Derivatives with a Type-2 Diabetes Mellitus-Alleviating Effect through Improving Intestinal L-Cell Functions.
Li H, Ma Q, Li X, Zheng C, Lin L, Gu J, Huang X, Yang H, Xu H, Xu F, Hua H, Cheng M, Li D
Journal of medicinal chemistry 2025 Aug 14;68(15):15520-15542
Journal of medicinal chemistry 2025 Aug 14;68(15):15520-15542
Indoleamine 2,3-dioxygenase can improve ovarian function in premature ovarian insufficiency via aromatic hydrocarbon receptor and regulatory T cells†.
Hu A, Mu Y, Huang G, Wang Z, Zhao S, Xu W, Chen P, Guo X
Biology of reproduction 2025 Aug 13;113(2):331-344
Biology of reproduction 2025 Aug 13;113(2):331-344
Exploring the Antitumor Mechanisms of Bai-Hua-She-She-Cao and Ban-Zhi-Lian against Head and Neck Squamous Cell Carcinoma: A Study on Natural Anticancer Therapeutics.
Zhang Y, Pan Y, Wang K
ACS omega 2025 Aug 12;10(31):34528-34538
ACS omega 2025 Aug 12;10(31):34528-34538
MLCK inhibition induces synthetic lethality in MYC-driven cancer.
Sun Z, Wu R, Liang X, Shi T, Zhang Y, Pan Z, Zhang W, Luan X
Cancer letters 2025 Aug 10;625:217803
Cancer letters 2025 Aug 10;625:217803
PCSK9 exacerbates sevoflurane-induced neuroinflammatory response and apoptosis by up-regulating cGAS-STING signal.
Su T, Si Y
Tissue & cell 2025 Apr;93:102739
Tissue & cell 2025 Apr;93:102739
Klotho improves Der p1-induced bronchial epithelial cell damage by inhibiting endoplasmic reticulum stress to regulate mitochondrial function.
Wang C, Liu Z, Xie X, Li Y, Sun L
Tissue & cell 2025 Apr;93:102646
Tissue & cell 2025 Apr;93:102646
Synergistic photoinduction of ferroptosis and apoptosis by a mitochondria-targeted iridium complex for bladder cancer therapy.
Zheng J, Zhang A, Du Q, Li C, Zhao Z, Li L, Zhang Z, Qin X, Li Y, Wang KN, Yu N
Journal of colloid and interface science 2025 Apr;683(Pt 1):420-431
Journal of colloid and interface science 2025 Apr;683(Pt 1):420-431
Porcine epidemic diarrhea virus nsp14 inhibited IFN-Ⅰ production by targeting RIG-I for degradation.
Li S, Wang L, Wen Y, Han J, Hou J, Hou Z, Xie J, Li H, Li X, Yang Y, Feng R
Virology 2025 Apr;605:110451
Virology 2025 Apr;605:110451
EGFR tyrosine kinase inhibitor ZZC4 overcomes acquired resistance to gefitinib.
Attiogbe MKI, Huang TT, Zhao HY, Wang HY, Cao L, Yan PP, Zhang SQ, Cao YX
Toxicology and applied pharmacology 2025 Apr;497:117280
Toxicology and applied pharmacology 2025 Apr;497:117280
Low molecular weight heparins promote migration and invasion of trophoblast cells through regulating the PI3K/AKT signaling pathway.
Zhou Q, Zhao Y, Fu X
Naunyn-Schmiedeberg's archives of pharmacology 2025 Apr;398(4):4645-4656
Naunyn-Schmiedeberg's archives of pharmacology 2025 Apr;398(4):4645-4656
Paeoniflorin-mediated downregulation of VEGFA: unveiling the therapeutic mechanism of buyang huanwu decoction in diabetic retinopathy.
Sun W, Wang R, Gong K, Wang L, Li F, Deng J
Naunyn-Schmiedeberg's archives of pharmacology 2025 Apr;398(4):4571-4582
Naunyn-Schmiedeberg's archives of pharmacology 2025 Apr;398(4):4571-4582
Oxidized Low-Density Lipoprotein Decreases the Survival of Bone Marrow Stem Cells via Inhibition of Bcl-2 Expression.
Li X, Li Y, Yu H, Men LL, Deng G, Liu Z, Du JL
Tissue engineering. Part A 2025 Apr;31(7-8):325-333
Tissue engineering. Part A 2025 Apr;31(7-8):325-333
Cinobufacini Inhibits Survival and Metastasis of Hepatocellular Carcinoma via c-Met Signaling Pathway.
Ma YN, Jiang XM, Hu XQ, Wang L, Gao JJ, Liu H, Qi FH, Song PP, Tang W
Chinese journal of integrative medicine 2025 Apr;31(4):311-325
Chinese journal of integrative medicine 2025 Apr;31(4):311-325
Bionic nanovesicles sequentially treat flaps with different durations of ischemia by thrombolysis and prevention of ischemia-reperfusion injury.
Yang L, Liu Y, Tao C, Cao Z, Guo S, Wei Z, Wang Y, Liu T, Chen L, Xiong K, Luo X, Ran J, Han W
Materials today. Bio 2025 Apr;31:101529
Materials today. Bio 2025 Apr;31:101529
Hepatoprotective effects of polysaccharide from Morchella esculenta are associated with activation of the AMPK/Sirt1 signaling pathway in mice with NAFLD.
Wang D, Zhang M, Zhang Y, Yin Z, Zhang S, Zhao Z, Duan Y
International journal of biological macromolecules 2025 Apr;301:140444
International journal of biological macromolecules 2025 Apr;301:140444
Molecular mechanisms of antiproliferative and pro-apoptotic effects of essential oil active constituents in MCF7 and T24 cancer cell lines: in vitro insights and in silico modelling of proapoptotic gene product-compound interactions.
Saini D, Chaudhary PK, Chaudhary JK, Kaur H, Verma GK, Pramanik SD, Roy P, Mirza-Shariff AA, Prasad R
Apoptosis : an international journal on programmed cell death 2025 Apr;30(3-4):805-825
Apoptosis : an international journal on programmed cell death 2025 Apr;30(3-4):805-825
Carboxymethyl polysaccharides from Poria cocos (Schw.) wolf: Structure, immunomodulatory, anti-inflammatory, tumor cell proliferation inhibition and antioxidant activity.
Liu H, Yang J, Tang Y, Xia X, Lin J
International journal of biological macromolecules 2025 Apr;299:140104
International journal of biological macromolecules 2025 Apr;299:140104
Chlorogenic acid improves SPS-induced PTSD-like behaviors in rats by regulating the crosstalk between Nrf2 and NF-κB signaling pathway.
Tang C, Gao J, Li S, Cheng H, Peng YY, Ding Y, Yang H, Ma XM, Wang HY, Long ZY, Lu XM, Wang YT
Free radical biology & medicine 2025 Apr;231:136-152
Free radical biology & medicine 2025 Apr;231:136-152
Design, synthesis and antitumor activity evaluation of novel modified 18β-glycyrrhetinate derivatives as PPARγ agonists.
Lin H, Cui S, Xu X, Chen Q, Ge J, Ai D, Zhu J, Tao Y, Wang L, Ruan L, Ge W
Bioorganic chemistry 2025 Apr;157:108307
Bioorganic chemistry 2025 Apr;157:108307
Palmatine activation of TFEB enhances autophagy and alleviates endoplasmic reticulum stress in intervertebral disc degeneration.
Yu H, Chen K, Li X, Liang J, Jin Y, Bao Y, Chen H, Gou Y, Lu K, Wu L, Lin Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156431
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156431
Huaiqihuang (HQH) protects podocytes from high glucose-induced apoptosis and inflammation response by regulating PI3K/AKT/mTOR pathway.
Zhang P, Liu Z, Ma G, Wang J, Shao J, Ma C, Wang L, Ma C
Archives of physiology and biochemistry 2025 Apr;131(2):285-292
Archives of physiology and biochemistry 2025 Apr;131(2):285-292
Dexmedetomidine Promotes Angiogenesis After Ischemic Stroke Through the NRF2/HO-1/VEGF Pathway.
Tao Z, Li P, Tang Y, Yang W, Li Y, Yang J, Tian J, Zhang Y, Zou Y, Xu B, Zhao X
Neurochemical research 2025 Apr 9;50(2):138
Neurochemical research 2025 Apr 9;50(2):138
Early secretory antigen target of 6-kDa of Mycobacterium tuberculosis inhibits macrophage apoptosis and host defense via TLR2.
Zhang L, Fang F, Liu D, Xia G, Feng T, Lv J, Qi J, Li T, Liu H, Xu T, Wu F, Song C, Li W, Wang X, Chang X, Wang H, Wang T, Qian Z
Respiratory research 2025 Apr 9;26(1):131
Respiratory research 2025 Apr 9;26(1):131
The highly expressed GOLPH3 in colorectal cancer cells activates smoothened to drive glycolysis and promote cancer cell growth and radiotherapy resistance.
Zhu K, Fan J, Cai H, Zhou C, Gong Z, Li Z, Yu J
Journal of gastrointestinal oncology 2025 Apr 30;16(2):415-434
Journal of gastrointestinal oncology 2025 Apr 30;16(2):415-434
The IL-6 autocrine loop promoting IFN-γ-induced fibroblast senescence is involved in psychological stress-mediated exacerbation of vitiligo.
Cao C, Xu W, Lei J, Zheng Y, Zhang A, Xu A, Lin F, Zhou M
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2025 Apr 29;74(1):72
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2025 Apr 29;74(1):72
KIF2C promotes oral squamous cell carcinoma progression via PLK1 upregulation: implications for biomarker development and therapeutic targeting.
Wang C, Su Y, Shi J, Feng G
Journal of molecular histology 2025 Apr 28;56(3):146
Journal of molecular histology 2025 Apr 28;56(3):146
The cardioprotective effects of acteoside in myocardial ischemia reperfusion injury and the underlying mechanism.
Li J, Guo Y, Yang Y, Xue Q, Cao H, Yang G, Sun Z, Jia LL, Yu HB
BMC cardiovascular disorders 2025 Apr 26;25(1):329
BMC cardiovascular disorders 2025 Apr 26;25(1):329
PCSK9 Targeted Autophagosome-Tethering Compounds: Design, Synthesis, and Antiatherosclerosis Evaluation.
Wu H, Zhang Z, Xue Y, Guo J, Ouyang Z, Cao Z, Guo W, Zhang Q, Wang M, Gu X
Journal of medicinal chemistry 2025 Apr 24;68(8):8190-8207
Journal of medicinal chemistry 2025 Apr 24;68(8):8190-8207
SAP30 promotes clear cell renal cell carcinoma proliferation and inhibits apoptosis through the MT1G axis.
Guo W, Wang S, Yang Z, Dong Y, Xia Z, Xue W, Zhang C
European journal of medical research 2025 Apr 18;30(1):306
European journal of medical research 2025 Apr 18;30(1):306
Dl-3-n-butylphthalide ameliorates diabetic foot ulcer by inhibiting apoptosis and promoting angiogenesis.
Wei WH, Bai YL, Zhu D, Zhang JY, Yin QC, Li Q, Shen CQ, Jin PS
World journal of diabetes 2025 Apr 15;16(4):101916
World journal of diabetes 2025 Apr 15;16(4):101916
Analysis and identification of PTBP2 as an oncogene in hepatocellular carcinoma.
Li Y, Zhai F, Kong L, Zhu J, Li H, Jin X
Discover oncology 2025 Apr 12;16(1):520
Discover oncology 2025 Apr 12;16(1):520
Tannic acid‑cerium nanoenzymes serve as broad-spectrum antioxidants to alleviate acute kidney injury by modulating macrophage polarization, mitophagy and endoplasmic reticulum stress.
Fu H, Wang Y, Huang B, Liang Z, Li Y, Cao Z, Wu J, Zhao Y
Journal of controlled release : official journal of the Controlled Release Society 2025 Apr 10;380:892-909
Journal of controlled release : official journal of the Controlled Release Society 2025 Apr 10;380:892-909
Aggregation-Induced Emission-Active Photosensitizer-Mediated Photodynamic Therapy for Anti-Psoriasis.
Zhu P, Wu Z, Yang Z, Tang T, Liao Y, Zhao W, Huang Y, Chen T, Li J, Nong C, Wu Z, Hu G, Liu Y, Chen Y
Research (Washington, D.C.) 2024;7:0344
Research (Washington, D.C.) 2024;7:0344
ITGB1 Alleviates High Glucose-Induced Myocardial Cell Injury by Inhibiting Endoplasmic Reticulum Stress and Cell Apoptosis.
Cheng C, Li J, Zhang D, Xu D, Yu W
International heart journal 2024;65(6):1137-1143
International heart journal 2024;65(6):1137-1143
Sodium Tanshinone IIA Sulfonate Protects Primary Cardiomyocytes Against Radiation-Induced Myocardial Injury via the p38 Pathway.
Ma L, Zhang T, Wang R, Li C, Yu J, Wang G, Cai H, Li T, Zhang Y, Li Y, Xie P
International heart journal 2024;65(4):730-737
International heart journal 2024;65(4):730-737
Long non-coding RNA HOTAIR promotes tumourigenesis by affecting proliferation, invasion, migration, and apoptosis of liver cancer cells.
Zheng X, Cui R, Jiao Y, Chu D, Wang B, Li N
Folia histochemica et cytobiologica 2024;62(4):165-179
Folia histochemica et cytobiologica 2024;62(4):165-179
Mitofusin 2 inhibits high glucose-induced apoptosis of human lens epithelial cells via modulating mitochondrial function and autophagy.
Guo YY, Zhao JY, Li HR, Guo Z, Shen HY
Folia histochemica et cytobiologica 2024;62(2):76-86
Folia histochemica et cytobiologica 2024;62(2):76-86
Ginsenoside Rg2 Attenuates Aging-Induced Liver Injury via Inhibiting Caspase 8-Mediated Pyroptosis, Apoptosis and Modulating Gut Microbiota.
Gao XF, Ji BY, Zhang JJ, Wang Z, Jiang S, Hu JN, Gong XJ, Zhang JT, Tsopmejio ISN, Li W
The American journal of Chinese medicine 2024;52(5):1427-1449
The American journal of Chinese medicine 2024;52(5):1427-1449
Lobetyolin Suppresses the Proliferation of Hepatocellular Carcinoma through Activating DUSP1-ERK1/2 Signaling Pathway.
Hu J, Wang D, Wang F, Lin P
Biological & pharmaceutical bulletin 2024;47(10):1751-1758
Biological & pharmaceutical bulletin 2024;47(10):1751-1758
Isoflurane preconditioning protects against renal ischemia/reperfusion injury in diabetes via activation of the Brg1/Nrf2/HO-1 signaling pathway.
Gong D, Dong Z, Chen X, Chen H, Lin H
Acta cirurgica brasileira 2024;39:e396124
Acta cirurgica brasileira 2024;39:e396124
Metformin alleviates bevacizumab-induced vascular endothelial injury in mice through growth differentiation factor 15 upregulation.
Chen L, Yin Y, Liu C, Liu J, Zheng M, Tang Y, Yang Q, Liu J, Chen F, Liu L, Liu G
Iranian journal of basic medical sciences 2024;27(3):343-351
Iranian journal of basic medical sciences 2024;27(3):343-351
Catalpol alleviates amyloid- generation and neuronal oxidative stress injury via activating the Keap1-Nrf2/ARE signaling pathway in the immortalized lymphocytes from patients with late-onset Alzheimer's disease and SKNMC cells co-culture model.
Xiang C, Lu Y, Hao R, Wei Y, Hu Y, Yu G
Iranian journal of basic medical sciences 2024;27(12):1547-1557
Iranian journal of basic medical sciences 2024;27(12):1547-1557
Shock Wave Therapy Alleviates Hypoxia/Reoxygenation-Induced Cardiomyocyte Injury by Inhibiting Both Apoptosis and Ferroptosis.
Wang J, Jia N, Zhu K, Xu K, Yan M, Lan M, Liu J, Liu B, Shen T, He Q
Analytical cellular pathology (Amsterdam) 2024;2024:8753898
Analytical cellular pathology (Amsterdam) 2024;2024:8753898
Dissection of Targeting Molecular Mechanisms of Celastrol-induced Nephrotoxicity via A Combined Deconvolution Strategy of Chemoproteomics and Metabolomics.
Liu X, Zhang Q, Wang P, Peng X, An Y, Chen J, Huang J, Qin S, He H, Hao M, Tian J, Yi L, Lei M, Luo P, Wang J, Zhang X
International journal of biological sciences 2024;20(12):4601-4617
International journal of biological sciences 2024;20(12):4601-4617
lncRNA GAPLINC regulates vascular endothelial cell apoptosis in atherosclerosis.
Pan J, Wang B, Pu X, Qiu C, Li D, Wu Z, Zhang H, He Y
Archives of medical science : AMS 2024;20(1):216-232
Archives of medical science : AMS 2024;20(1):216-232
Therapeutic potential of salidroside in type I diabetic erectile dysfunction: Attenuation of oxidative stress and apoptosis via the Nrf2/HO-1 pathway.
Li Z, Jia B, Guo Z, Zhang K, Zhao D, Li Z, Fu Q
PloS one 2024;19(7):e0306926
PloS one 2024;19(7):e0306926
Exploring the effects of hypoxia and reoxygenation time on hepatocyte apoptosis and inflammation.
Xu X, Zhou T, Tulahong A, Ruze R, Shao Y
PloS one 2024;19(11):e0310535
PloS one 2024;19(11):e0310535
Mitochondrial Targeted Cerium Oxide Nanoclusters for Radiation Protection and Promoting Hematopoiesis.
Yang L, Ran H, Yin Y, Liu J, Lu B, Ran X, Luo S, Wang W, Yang Z, Li R
International journal of nanomedicine 2024;19:6463-6483
International journal of nanomedicine 2024;19:6463-6483
Anti-Cancer Potency of Copper-Doped Carbon Quantum Dots Against Breast Cancer Progression.
Wang M, Lan S, Zhang W, Jin Q, Du H, Sun X, He L, Meng X, Su L, Liu G
International journal of nanomedicine 2024;19:1985-2004
International journal of nanomedicine 2024;19:1985-2004
Polyoxometalates Ameliorate Metabolic Dysfunction-Associated Steatotic Liver Disease by Activating the AMPK Signaling Pathway.
Wang D, Wang J, Yin Z, Gong K, Zhang S, Zha Z, Duan Y
International journal of nanomedicine 2024;19:10839-10856
International journal of nanomedicine 2024;19:10839-10856
Morphological and functional observations of a novel model of retinal ischemia injury induced by bilateral carotid artery stenosis in mice.
Shu L, Zhang YJ, Chen XX, Sun XH
International journal of ophthalmology 2024;17(12):2192-2202
International journal of ophthalmology 2024;17(12):2192-2202
Integrating network pharmacology with experimental validation to investigate the mechanism of Wuwei Zishen formula in improving perimenopausal syndrome.
Fu X, Wang H, Gai M, Dai Y, Chang J, Zhang H
American journal of translational research 2024;16(6):2190-2211
American journal of translational research 2024;16(6):2190-2211
PHGDH is Key to a Prognostic Multigene Signature and a Potential Therapeutic Target in Acute Myeloid Leukemia.
Zhong J, Huang K, Xie S, Tan A, Peng J, Nie D, Ma L, Li Y
Journal of Cancer 2024;15(9):2538-2548
Journal of Cancer 2024;15(9):2538-2548
KYNU Expression Promotes Cisplatin Resistance in Esophageal Cancer.
Lu Y, Zhao X, Yuan M, Zhao M, Liu K, Zhang M, Qiu X, Yu X, Liu X, Wei D, Xie J, Cheng Z
Journal of Cancer 2024;15(9):2475-2485
Journal of Cancer 2024;15(9):2475-2485
Pan-Cancer Analysis of PGAM1 and Its Experimental Validation in Uveal Melanoma Progression.
Niu W, Yang Y, Teng Y, Zhang N, Li X, Qin Y
Journal of Cancer 2024;15(7):2074-2094
Journal of Cancer 2024;15(7):2074-2094
The chiisanoside derivatives present in the leaves of Acanthopanax sessiliflorus activate autophagy through the LRP6/GSK3β axis and thereafter inhibit oxidative stress, thereby counteracting cisplatin-induced ototoxicity.
Zhang W, Teng H, Zhao T, Eglitis RI, Wang X, Yu Z, Qu S, Wang H, Zhao Y, Fan B, Liu S, Zhao Y
Frontiers in pharmacology 2024;15:1518810
Frontiers in pharmacology 2024;15:1518810
Targeting autophagy: polydatin's role in inducing cell death in AML.
Fu P, Luo Q, Wang C, Chen L, Dong C, Yang K, Wu G
Frontiers in pharmacology 2024;15:1470217
Frontiers in pharmacology 2024;15:1470217
Inhibition of NNMT enhances drug sensitivity in lung cancer cells through mediation of autophagy.
Wang J, Zhang M, You X, Xu Y, Zhang C, Li Y, Yang C, Wang Q
Frontiers in pharmacology 2024;15:1415310
Frontiers in pharmacology 2024;15:1415310
Multidimensional role of adapalene in regulating cell death in multiple myeloma.
Cao X, Xiang J, Zhang Q, Liu J, Zhou D, Xu Y, Xu P, Chen B, Bai H
Frontiers in pharmacology 2024;15:1415224
Frontiers in pharmacology 2024;15:1415224
B4 suppresses lymphoma progression by inhibiting fibroblast growth factor binding protein 1 through intrinsic apoptosis.
Varier KM, Dan G, Li X, Liu W, Jiang F, Linghu KG, Li Y, Ben-David Y, Zhang N, Xiao C, Gajendran B, Shen X
Frontiers in pharmacology 2024;15:1408389
Frontiers in pharmacology 2024;15:1408389
The therapeutic mechanism of Compound Lurong Jiangu Capsule for the treatment of cadmium-induced osteoporosis: network pharmacology and experimental verification.
Zhou YS, Huang J, Cao WX, Yu AX, Li P, Liang JL, Leng XY, Jin J, Yu P, Liu J
Frontiers in endocrinology 2024;15:1331488
Frontiers in endocrinology 2024;15:1331488
Neoadjuvant immunotherapy plus chemotherapy for squamous cell carcinoma of the paranasal sinus: a case report.
Sun Y, Yang G, Sun R, Cao F
Frontiers in oncology 2024;14:1462993
Frontiers in oncology 2024;14:1462993
Histone deacetylase 3-specific inhibitor RGFP966 attenuates oxidative stress and inflammation after traumatic brain injury by activating the Nrf2 pathway.
Xu L, An T, Jia B, Wu Q, Shen J, Jin J, Liu J, Li C
Burns & trauma 2024;12:tkad062
Burns & trauma 2024;12:tkad062
Activating autophagy promotes skin regeneration induced by mechanical stretch during tissue expansion.
Du J, Liu W, Song Y, Zhang Y, Dong C, Xiong S, Huang Z, Wang T, Ding J, He Q, Yu Z, Ma X
Burns & trauma 2024;12:tkad057
Burns & trauma 2024;12:tkad057
New molecular mechanisms of quercetin in improving recurrent spontaneous abortion based on in-depth network pharmacology and molecular docking.
Wang D, Li X, Li Y, Wang R, Wang C, Li Y
Frontiers in chemistry 2024;12:1407667
Frontiers in chemistry 2024;12:1407667
ACSS2 enables melanoma cell survival and tumor metastasis by negatively regulating the Hippo pathway.
Zhang B, Zhu Q, Qu D, Zhao M, Du J, Zhang H, Wang H, Jiang L, Yi X, Guo S, Wang H, Yang Y, Guo W
Frontiers in molecular biosciences 2024;11:1423795
Frontiers in molecular biosciences 2024;11:1423795
Listeria monocytogenes: possible mechanism of infection of goat uterus and its effects on uterine autophagy and cell apoptosis.
Hong H, Hu Y, Shi S, Liu B, Zheng W, Bo R, Xu Z, Wu Y, Cao Y
Frontiers in veterinary science 2024;11:1413523
Frontiers in veterinary science 2024;11:1413523
Low-Dose LPS Modulates Microglia/Macrophages Phenotypic Transformation to Amplify Rehabilitation Effects in Chronic Spinal Cord Injured (CSCI) Mice.
Zhong J, He Y, Zhao Q, Luo H, Zhang Q, Tian Y, Liu Y, Yang C, Yin Y, Yu L, Pan L, Tan B
Molecular neurobiology 2024 Sep;61(9):6484-6500
Molecular neurobiology 2024 Sep;61(9):6484-6500
HSP70 protects PC12 cells against TBHP-induced apoptosis and oxidative stress by activating the Nrf2/HO-1 signaling pathway.
Deng B, He X, Wang Z, Kang J, Zhang G, Li L, Kang X
In vitro cellular & developmental biology. Animal 2024 Sep;60(8):868-878
In vitro cellular & developmental biology. Animal 2024 Sep;60(8):868-878
ESF1 positively regulates MDM2 and promotes tumorigenesis.
Zhang P, Sun C, Yin T, Guo J, Chong D, Tang Y, Liu Y, Li Y, Gu Y, Lu L
International journal of biological macromolecules 2024 Sep;276(Pt 1):133652
International journal of biological macromolecules 2024 Sep;276(Pt 1):133652
UFL1 regulates cellular homeostasis by targeting endoplasmic reticulum and mitochondria in NEFA-stimulated bovine mammary epithelial cells via the IRE1α/XBP1 pathway.
Yan Y, Huang J, Chen X, Li Y, Zhao W, Li C
Free radical biology & medicine 2024 Sep;222:16-26
Free radical biology & medicine 2024 Sep;222:16-26
Pyrimidine compounds BY4003 and BY4008 inhibit glioblastoma cells growth via modulating JAK3/STAT3 signaling pathway.
Ahmad N, Chen L, Yuan Z, Ma X, Yang X, Wang Y, Zhao Y, Jin H, Khaidamah N, Wang J, Lu J, Liu Z, Wu M, Wang Q, Qi Y, Wang C, Zhao Y, Piao Y, Huang R, Diao Y, Deng S, Shu X
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2024 Sep;21(5):e00431
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2024 Sep;21(5):e00431
Enhanced glioma cell death with ZnO nanorod flowers and temozolomide combination therapy through autophagy and mitophagy pathways.
Li Y, Ma Y, Li J, Lu Y, Liu H, Gao M, Cao J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:117149
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:117149
Combining the novel FLT3 and MERTK dual inhibitor MRX-2843 with venetoclax results in promising antileukemic activity against FLT3-ITD AML.
Wu S, Liu F, Gai Y, Carter J, Edwards H, Hüttemann M, Wang G, Li C, Taub JW, Wang Y, Ge Y
Leukemia research 2024 Sep;144:107547
Leukemia research 2024 Sep;144:107547
Catalpol alleviates heat stroke-induced liver injury in mice by downregulating the JAK/STAT signaling pathway.
Ji XY, Feng JT, Zhou ZY, Zhang YY, Ma SZ, Wang XQ, Zhang B
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155853
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155853
Identification of Matrine as a Kirsten rats Arcomaviral oncogene homolog inhibitor alleviating chemotherapy-induced neuropathic pain.
Zhu C, Zhang M, Gong S, Du J, Ma L, Liu Y, Li Y, Yu J, Liu N
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155841
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155841
Quercetin ameliorates oxidative stress-induced apoptosis of granulosa cells in dairy cow follicular cysts by activating autophagy via the SIRT1/ROS/AMPK signaling pathway.
Duan H, Wang F, Wang K, Yang S, Zhang R, Xue C, Zhang L, Ma X, Du X, Kang J, Zhang Y, Zhao X, Hu J, Xiao L
Journal of animal science and biotechnology 2024 Sep 5;15(1):119
Journal of animal science and biotechnology 2024 Sep 5;15(1):119
LncRNA OIP5-AS1 regulates ferroptosis and mitochondrial dysfunction-mediated apoptosis in spinal cord injury by targeting the miR-128-3p/Nrf2 axis.
Jiang Z, Zhang W, Zhang J
Heliyon 2024 Sep 30;10(18):e37704
Heliyon 2024 Sep 30;10(18):e37704
Astrocytic LRP1 enables mitochondria transfer to neurons and mitigates brain ischemic stroke by suppressing ARF1 lactylation.
Zhou J, Zhang L, Peng J, Zhang X, Zhang F, Wu Y, Huang A, Du F, Liao Y, He Y, Xie Y, Gu L, Kuang C, Ou W, Xie M, Tu T, Pang J, Zhang D, Guo K, Feng Y, Yin S, Cao Y, Li T, Jiang Y
Cell metabolism 2024 Sep 3;36(9):2054-2068.e14
Cell metabolism 2024 Sep 3;36(9):2054-2068.e14
Palliative effect of rotating magnetic field on glucocorticoid-induced osteonecrosis of the femoral head in rats by regulating osteoblast differentiation.
Yang H, Nie S, Zhou C, Li M, Yu Q, Mo Y, Wei Y, Wang X
Biochemical and biophysical research communications 2024 Sep 17;725:150265
Biochemical and biophysical research communications 2024 Sep 17;725:150265
Da-Chai-Hu-Tang Formula inhibits the progression and metastasis in HepG2 cells through modulation of the PI3K/AKT/STAT3-induced cell cycle arrest and apoptosis.
Duan ZW, Liu Y, Zhang PP, Hu JY, Mo ZX, Liu WQ, Ma X, Zhou XH, Wang XH, Hu XH, Wei SL
Journal of ethnopharmacology 2024 Sep 15;331:118293
Journal of ethnopharmacology 2024 Sep 15;331:118293
A New Class of Gold(I) NHC Complexes with Proapoptotic and Resensitizing Properties towards Multidrug Resistant Leukemia Cells Overexpressing BCL-2.
Bannwart F, Richter LF, Stifel S, Rueter J, Lode HN, Correia JDG, Kühn FE, Prokop A
Journal of medicinal chemistry 2024 Sep 12;67(17):15494-15508
Journal of medicinal chemistry 2024 Sep 12;67(17):15494-15508
DMDD, isolated from Averrhoa carambola L., ameliorates diabetic nephropathy by regulating endoplasmic reticulum stress-autophagy crosstalk.
Shi J, Wang Y, Liang T, Wang X, Xie J, Huang R, Xu X, Wei X
Chinese medicine 2024 Sep 12;19(1):125
Chinese medicine 2024 Sep 12;19(1):125
Gastrodin Alleviates Angiotensin II-Induced Hypertension and Myocardial Apoptosis via Inhibition of the PRDX2/p53 Pathway In Vivo and In Vitro.
Xu N, Xie Q, Chen Y, Li J, Zhang X, Zheng H, Cheng Y, Wu M, Shen A, Wei L, Yao M, Yang Y, Sferra TJ, Jafri A, Fang Y, Peng J
Pharmaceuticals (Basel, Switzerland) 2024 Sep 12;17(9)
Pharmaceuticals (Basel, Switzerland) 2024 Sep 12;17(9)
CCDC113 promotes colorectal cancer tumorigenesis and metastasis via TGF-β signaling pathway.
Hou C, Yang Y, Wang P, Xie H, Jin S, Zhao L, Wu G, Xing H, Chen H, Liu B, Du C, Sun X, He L
Cell death & disease 2024 Sep 11;15(9):666
Cell death & disease 2024 Sep 11;15(9):666
SS-31 mitigates oxidative stress and restores mitochondrial function in cigarette smoke-damaged oral epithelial cells via PINK1-mediated mitophagy.
Ye P, Liu H, Qin Y, Li Z, Huang Z, Bu X, Peng Q, Duan N, Wang W, Wang X
Chemico-biological interactions 2024 Sep 1;400:111166
Chemico-biological interactions 2024 Sep 1;400:111166
Roles of m(6)A modification in regulating PPER pathway in cadmium-induced pancreatic β cell death.
Sun Y, Li R, Li W, Zhang N, Liu G, Zhao B, Mei Z, Gu S, He Z
Ecotoxicology and environmental safety 2024 Sep 1;282:116672
Ecotoxicology and environmental safety 2024 Sep 1;282:116672
Placental growth factor alleviates hyperglycemia-induced trophoblast pyroptosis by regulating mitophagy.
Tao J, Rao Y, Wang J, Tan S, Zhao J, Cao Z, He L, Meng J, Wu P, Wang Z
The journal of obstetrics and gynaecology research 2024 Oct;50(10):1813-1829
The journal of obstetrics and gynaecology research 2024 Oct;50(10):1813-1829
Groenlandicine enhances cisplatin sensitivity in cisplatin-resistant osteosarcoma cells through the BAX/Bcl-2/Caspase-9/Caspase-3 pathway.
Zhao Z, Wu Q, Xu Y, Qin Y, Pan R, Meng Q, Li S
Journal of bone oncology 2024 Oct;48:100631
Journal of bone oncology 2024 Oct;48:100631
Emodin induces ferroptosis in colorectal cancer through NCOA4-mediated ferritinophagy and NF-κb pathway inactivation.
Shen Z, Zhao L, Yoo SA, Lin Z, Zhang Y, Yang W, Piao J
Apoptosis : an international journal on programmed cell death 2024 Oct;29(9-10):1810-1823
Apoptosis : an international journal on programmed cell death 2024 Oct;29(9-10):1810-1823
Semi-synthesis and in vitro anti-cancer effects evaluation of novel xanthohumol derivatives.
Sun X, Chen J, Huang D, Ding F, Zhao L, Li HM, Wang XS, Zhang YX, Wu CZ
Molecular diversity 2024 Oct;28(5):2749-2758
Molecular diversity 2024 Oct;28(5):2749-2758
Lenvatinib acts on platelet‑derived growth factor receptor β to suppress the malignant behaviors of gastric cancer cells.
Tong X, Du J, Jiang Q, Wu Q, Zhao S, Chen S
Oncology letters 2024 Oct;28(4):483
Oncology letters 2024 Oct;28(4):483
Prebiotic stachyose inhibits PRDX5 activity and castration-resistant prostate cancer development.
Wang R, Pan Y, Zhang L, Wang J, Ni J, Ding Y, Wang S, Yin J, Ding L, Ran X, Fan S, Sun Q, Tan SY, Koeffler HP, Li J, Mi Y, Chen YQ
International journal of biological macromolecules 2024 Oct;278(Pt 3):134844
International journal of biological macromolecules 2024 Oct;278(Pt 3):134844
Investigation on the mechanism of androsta-4,6,8,14-tetraene-3,11,16-trione against acute lymphoblastic leukemia.
Chen D, Wang Y, Xiao S, Cheng G, Liu Y, Zhao T, Cao J, Wen Y
The Journal of steroid biochemistry and molecular biology 2024 Oct;243:106573
The Journal of steroid biochemistry and molecular biology 2024 Oct;243:106573
Panobinostat sensitizes AraC-resistant AML cells to the combination of azacitidine and venetoclax.
Zhao J, Wu S, Wang D, Edwards H, Thibodeau J, Kim S, Stemmer P, Wang G, Jin J, Savasan S, Taub JW, Ge Y
Biochemical pharmacology 2024 Oct;228:116065
Biochemical pharmacology 2024 Oct;228:116065
Procyanidine alleviates bisphenol A-induced apoptosis in TM3 cells via the Nrf2 signaling pathway.
Pan F, Yang W, Zhao T, Liu K, Zhao S, Zhao L
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Oct;192:114908
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Oct;192:114908
SFRP4 contributes to insulin resistance-induced polycystic ovary syndrome by triggering ovarian granulosa cell hyperandrogenism and apoptosis through the nuclear β-catenin/IL-6 signaling axis.
Wang J, Gui R, Li Y, Li Z, Li Z, Liu S, Zhang M, Qian L, Fan X, Xiong Y
Biochimica et biophysica acta. Molecular cell research 2024 Oct;1871(7):119822
Biochimica et biophysica acta. Molecular cell research 2024 Oct;1871(7):119822
Effects of exogenous hydrogen sulfide and honokiol intervention on the proliferation, apoptosis, and calcium signaling pathway of rat enteric glial cells.
Liu P, Zhang X, Zhao N, Dai J, Liang G
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Oct;179:117290
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Oct;179:117290
Modified EBP-bFGF targeting endogenous renal extracellular matrix protects against renal ischemia-reperfusion injury in rats.
Li X, Shi C, Zhou R, Chen X, Xu Q, Zhao C, Ma M, Ao X, Liu Y
Journal of biomedical materials research. Part A 2024 Oct;112(10):1827-1839
Journal of biomedical materials research. Part A 2024 Oct;112(10):1827-1839
N-Acetylcysteine assists muscle development in offspring of mice subjected to maternal heat stress during pregnancy.
Lu J, Zhao P, Ding X, Liu Y, Li H
Journal of the science of food and agriculture 2024 Oct;104(13):7895-7906
Journal of the science of food and agriculture 2024 Oct;104(13):7895-7906
Effect of dapagliflozin on pulmonary vascular remodeling in rats with chronic hypoxic pulmonary arterial hypertension.
Xu Y, Liang W, Huo J, Zhang T, Feng T, Li M, Zhu Z, Zhou P, Zhu S, Lu Y, Wang L
Journal of receptor and signal transduction research 2024 Oct-Dec;44(5-6):174-180
Journal of receptor and signal transduction research 2024 Oct-Dec;44(5-6):174-180
Inhibition of HOXC11 by artesunate induces ferroptosis and suppresses ovarian cancer progression through transcriptional regulation of the PROM2/PI3K/AKT pathway.
Li J, Feng L, Yuan Y, He T, Zou X, Su B, Liu K, Yang X
World journal of surgical oncology 2024 Oct 8;22(1):268
World journal of surgical oncology 2024 Oct 8;22(1):268
Siwu decoction exerts a phytoestrogenic osteoprotective effect on postmenopausal osteoporosis via the estrogen receptor/phosphatidylinositol 3-kinase/serine/threonine protein kinase pathway.
Yang J, Cong N, Shi D, Chen S, Zhang Z, Zhao P
Journal of ethnopharmacology 2024 Oct 5;332:118366
Journal of ethnopharmacology 2024 Oct 5;332:118366
PYGL regulation of glycolysis and apoptosis in glioma cells under hypoxic conditions via HIF1α-dependent mechanisms.
Cao T, Wang J
Translational cancer research 2024 Oct 31;13(10):5627-5648
Translational cancer research 2024 Oct 31;13(10):5627-5648
Mutation of Pseudomonas aeruginosa lasI/rhlI diminishes its cytotoxicity, oxidative stress, inflammation, and apoptosis on THP-1 macrophages.
Ren Y, You X, Zhu R, Li D, Wang C, He Z, Hu Y, Li Y, Liu X, Li Y
Microbiology spectrum 2024 Oct 3;12(10):e0414623
Microbiology spectrum 2024 Oct 3;12(10):e0414623
HIV Protein Nef Induces Cardiomyopathy Through Induction of Bcl2 and p21.
Kondrachuk O, Ciccone P, Ford N, Hong K, Kimura Y, Zi J, Yusuf S, Alkousa A, Tailor N, Rajkumar R, Rappaport J, Gupta MK
International journal of molecular sciences 2024 Oct 23;25(21)
International journal of molecular sciences 2024 Oct 23;25(21)
[Aumolertinib combined with anlotinib inhibits proliferation of non-small cell lung cancer cells by down-regulating the PI3K/AKT pathway].
Yang Y, Liu X, Liu W, Zhou X, Zhang Z, Hu Y, Liu P, Li X, Liu H, Li S
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2024 Oct 20;44(10):1965-1975
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2024 Oct 20;44(10):1965-1975
Targeting NUF2 suppresses gastric cancer progression through G2/M phase arrest and apoptosis induction.
Long B, Zhou H, Xiao L, Jiang X, Li J, Ma Z, He N, Xin W, Zhang B, Zhu X, Yu Z, Jiao Z
Chinese medical journal 2024 Oct 20;137(20):2437-2451
Chinese medical journal 2024 Oct 20;137(20):2437-2451
Regorafenib promotes antitumor progression in melanoma by reducing RRM2.
Xuan X, Li Y, Huang C, Zhang Y
iScience 2024 Oct 18;27(10):110993
iScience 2024 Oct 18;27(10):110993
Overexpression of USP35 enhances the protective effect of hUC-MSCs and their extracellular vesicles in oxygen-glucose deprivation/reperfusion-induced SH-SY5Y cells via stabilizing FUNDC1.
Wang S, Li X, Wang T, Sun Z, Feng E, Jin Y
Communications biology 2024 Oct 15;7(1):1330
Communications biology 2024 Oct 15;7(1):1330
Loss of NAT10 Reduces the Translation of Kmt5a mRNA Through ac4C Modification in Cardiomyocytes and Induces Heart Failure.
Xu T, Du T, Zhuang X, He X, Yan Y, Wu J, Zhou H, Li Y, Liao X, He J, Liu C, Dong Y, Ou J, Lin S, Chen D, Huang ZP
Journal of the American Heart Association 2024 Oct 15;13(20):e035714
Journal of the American Heart Association 2024 Oct 15;13(20):e035714
LncRNA Pvt1 aggravates cardiomyocyte apoptosis via the microRNA-216/Ccnd3 axis.
Hu Y, Luo M, Xue Y, Lv D, Huang L, Li X, Shen J
Heliyon 2024 Oct 15;10(19):e38261
Heliyon 2024 Oct 15;10(19):e38261
A quinoline-2-thione derivative as a novel chemotherapy drug candidate displays anti-tumor activity in vitro and in vivo.
Zhao JJ, Zhao J, Lin F, Xu LL, Chen ZG, Jiang YQ, Zhao GA
BMC cancer 2024 Oct 13;24(1):1272
BMC cancer 2024 Oct 13;24(1):1272
Lipoxin A4 modulates the PKA/CREB and NF-κB signaling pathway to mitigate chondrocyte catabolism and apoptosis in temporomandibular joint osteoarthritis.
Tuerxun P, Ng T, Sun J, Ou F, Jia X, Zhao K, Zhu P
Experimental cell research 2024 Oct 1;442(2):114249
Experimental cell research 2024 Oct 1;442(2):114249
Donafenib inhibits PARP1 expression and induces DNA damage, in combination with PARP1 inhibitors promotes apoptosis in liver cancer cells.
Jiang J, Yang P, Xu X, Yuan H, Zhu H
Anti-cancer drugs 2024 Oct 1;35(9):789-805
Anti-cancer drugs 2024 Oct 1;35(9):789-805
Apoptosis mediated by crosstalk between mitochondria and endoplasmic reticulum: A possible cause of citrinin disruption of the intestinal barrier.
Li Y, Wang Y, Jiang Z, Yang C, Wu Y, Wu A, Zhang Q, Liu X, Xiao B, Feng Y, Wu J, Liang Z, Yuan Z
Ecotoxicology and environmental safety 2024 Oct 1;284:116877
Ecotoxicology and environmental safety 2024 Oct 1;284:116877
Prenatal exposure to dibutyl phthalate contributes to erectile dysfunction in offspring male rats by activating the RhoA/ROCK signalling pathway.
Liu S, Li J, Wang W, Zhang Y, Li S, Li T, Jiang J, Zhao F
Toxicology 2024 Nov;508:153925
Toxicology 2024 Nov;508:153925
Partial reduction of interleukin-33 signaling improves senescence and renal injury in diabetic nephropathy.
Chen L, Gao C, Yin X, Mo L, Cheng X, Chen H, Jiang C, Wu B, Zhao Y, Li H, Li Y, Li J, Chen L, Deng Q, Yao P, Tang Y
MedComm 2024 Nov;5(11):e742
MedComm 2024 Nov;5(11):e742
Sappanone A ameliorates acute lung injury through inhibiting the activation of the NF-κB signaling pathway.
Du J, Zhou P, Zhao X, He YT, He CS, Wang RY
Toxicology and applied pharmacology 2024 Nov;492:117127
Toxicology and applied pharmacology 2024 Nov;492:117127
Acrylamide Exposure Impairs Ovarian Tricarboxylic Acid Cycle and Reduces Oocyte Quality in Mouse.
Liu YC, Li RC, Wang WK, Chen YZ, He QK, Xu ZR, Yang YF, Cheng SY, Wang HL, Qi ZQ, Xu CL, Liu Y
Environmental toxicology 2024 Nov;39(11):5074-5085
Environmental toxicology 2024 Nov;39(11):5074-5085
E3 ubiquitin ligase TRIM31 alleviates dopaminergic neurodegeneration by promoting proteasomal degradation of VDAC1 in Parkinson's Disease model.
Zhao Z, Song X, Wang Y, Yu L, Huang G, Li Y, Zong R, Liu T, Ji Q, Zheng Y, Liu B, Zhu Q, Chen L, Gao C, Liu H
Cell death and differentiation 2024 Nov;31(11):1410-1421
Cell death and differentiation 2024 Nov;31(11):1410-1421
Rapamycin alleviates irradiation-induced parotid injury by enhancing the whole gland homeostasis.
Zhu Z, Song J, Zhang C, Zhang J, Shan Z
Oral diseases 2024 Nov;30(8):5050-5061
Oral diseases 2024 Nov;30(8):5050-5061
Ciclopirox platinum(IV) conjugates suppress tumors by promoting mitophagy and provoking immune responses.
Li S, Feng S, Chen Y, Sun B, Zhang N, Zhao Y, Han J, Liu Z, He YQ, Wang Q
Journal of inorganic biochemistry 2024 Nov;260:112696
Journal of inorganic biochemistry 2024 Nov;260:112696
Gut microbiota-driven metabolic alterations reveal the distinct pathogenicity of chemotherapy-induced cachexia in gastric cancer.
Wu J, Zhang R, Yin Z, Chen X, Mao R, Zheng X, Yuan M, Li H, Lu Y, Liu S, Gao X, Sun Q
Pharmacological research 2024 Nov;209:107476
Pharmacological research 2024 Nov;209:107476
Verapamil attenuates myocardial ischemia/reperfusion injury by inhibiting apoptosis via activating the JAK2/STAT3 signaling pathway.
Zhao Y, Huang W, Liu F, Sun Q, Shen D, Fan W, Huang D, Zhang Y, Gao F, Wang B
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Nov;180:117568
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Nov;180:117568
Modulating autophagy to boost the antitumor efficacy of TROP2-directed antibody-drug conjugate in pancreatic cancer.
Xu C, Huang X, Hu Q, Xue W, Zhou K, Li X, Nan Y, Ju D, Wang Z, Zhang X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Nov;180:117550
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Nov;180:117550
Dual-targeted halofuginone hydrobromide nanocomplexes for promotion of macrophage repolarization and apoptosis of rheumatoid arthritis fibroblast-like synoviocytes in adjuvant-induced arthritis in rats.
Zhu J, Lin Y, Li G, He Y, Su Z, Tang Y, Zhang Y, Xu Q, Yao Z, Zhou H, Liu B, Cai X
Journal of pharmaceutical analysis 2024 Nov;14(11):100981
Journal of pharmaceutical analysis 2024 Nov;14(11):100981
CaMKII Exacerbates Doxorubicin-Induced Cardiotoxicity by Promoting Ubiquitination Through USP10 Inhibition.
Yang Y, Wang Z, Wang N, Yang J, Yang L
Cancer medicine 2024 Nov;13(21):e70286
Cancer medicine 2024 Nov;13(21):e70286
Efficient, High-Quality Engineering of Therapeutic Extracellular Vesicles on an Integrated Nanoplatform.
Wang Y, Yang K, Huang Z, Wang Y, Xiao A, Jiang X, Liu F, Wang Z, Sun H, Hu Y, Wang Y, Wu H, Lin L, Jin Z, Du L, Sun J, Liu J, Yin D, Kong S, Song K, Chen X, Yang M, Mu W, Liu Z, Yu X, Chang L
ACS nano 2024 Nov 26;18(47):32421-32437
ACS nano 2024 Nov 26;18(47):32421-32437
Hyperoside induces ferroptosis in chronic myeloid leukemia cells by targeting NRF2.
Wei J, Chai Q, Qin Y, Li L, Guo C, Lu Z, Liu H
Molecular medicine (Cambridge, Mass.) 2024 Nov 21;30(1):224
Molecular medicine (Cambridge, Mass.) 2024 Nov 21;30(1):224
Effect and underlying mechanism of a photochemotherapy dual-function nanodrug delivery system for head and neck squamous cell carcinoma.
Lin Q, Liu HM, Wu LZ, Yu DD, Hua CY, Zou Y, Jiao WE, Li XP, Chen SM
Journal of translational medicine 2024 Nov 19;22(1):1043
Journal of translational medicine 2024 Nov 19;22(1):1043
αKlotho modulates BNIP3-mediated mitophagy by regulating FoxO3 to decrease mitochondrial ROS and apoptosis in contrast-induced acute kidney injury.
Zhu X, Lin Q, Yang Y, Li S, Shao X, Zhang W, Cai H, Li J, Wu J, Zhang K, Qi C, Zhang M, Che X, Gu L, Ni Z
Cellular and molecular life sciences : CMLS 2024 Nov 15;81(1):454
Cellular and molecular life sciences : CMLS 2024 Nov 15;81(1):454
Acrolein exposure affects ovarian function by interfering with glycolysis and mitochondrial energy metabolism in mouse.
Chen YZ, Wang WK, Yang YF, Cheng SY, Li LF, Shen H, Qi ZM, Liu Y
Environmental pollution (Barking, Essex : 1987) 2024 Nov 15;361:124776
Environmental pollution (Barking, Essex : 1987) 2024 Nov 15;361:124776
Inhibition of the FOXO1-ROCK1 axis mitigates cardiomyocyte injury under chronic hypoxia in Tetralogy of Fallot by maintaining mitochondrial quality control.
Ren C, Xi L, Li H, Pan Z, Li Y, Wang G, Dai J, He D, Fan S, Wang Q
Life sciences 2024 Nov 15;357:123084
Life sciences 2024 Nov 15;357:123084
Pesticide metabolite 3, 5, 6-trichloro-2-pyridinol causes massive damage to the cochlea resulting in hearing loss in adult mice.
Huang M, Mao S, Pan Y, Zhang Z, Gui F, Tan X, Hong Y, Chen R
Environmental pollution (Barking, Essex : 1987) 2024 Nov 1;360:124691
Environmental pollution (Barking, Essex : 1987) 2024 Nov 1;360:124691
L-Glutamine Substantially Improves 5-Fluorouracil-Induced Intestinal Mucositis by Modulating Gut Microbiota and Maintaining the Integrity of the Gut Barrier in Mice.
Kuo YR, Lin CH, Lin WS, Pan MH
Molecular nutrition & food research 2024 May;68(9):e2300704
Molecular nutrition & food research 2024 May;68(9):e2300704
Chlorogenic acid improves the development of porcine parthenogenetic embryos by regulating oxidative stress and ameliorating mitochondrial function.
Qu HX, Wang YQ, Dong YW, Qi JJ, Wei HK, Zhang Y, Sun H, Sun BX, Liang S
Reproduction in domestic animals = Zuchthygiene 2024 May;59(5):e14596
Reproduction in domestic animals = Zuchthygiene 2024 May;59(5):e14596
Synergistic anticancer effects of ginsenoside CK and gefitinib against gefitinib-resistant NSCLC by regulating the balance of angiogenic factors through HIF-1α/VEGF.
Song X, Wang L, Cai P, Xu Y, Liu Q, Fan D
Toxicology and applied pharmacology 2024 May;486:116938
Toxicology and applied pharmacology 2024 May;486:116938
LRP8 promotes tumorigenesis in ovarian cancer through inhibiting p53 signaling.
Xu Y, Zhou Y, Yi X, Nie X
Cell biology international 2024 May;48(5):626-637
Cell biology international 2024 May;48(5):626-637
Joint Analysis of Genome-wide DNA Methylation and Transcription Sequencing Identifies the Role of BAX Gene in Heat Stress-Induced-Sertoli Cells Apoptosis.
Hu Y, Li Q, Qian Z, BeiXiao, Luo K, Luo N
Reproductive sciences (Thousand Oaks, Calif.) 2024 May;31(5):1311-1322
Reproductive sciences (Thousand Oaks, Calif.) 2024 May;31(5):1311-1322
Food therapy of scutellarein ameliorates pirarubicin‑induced cardiotoxicity in rats by inhibiting apoptosis and ferroptosis through regulation of NOX2‑induced oxidative stress.
Lan Y, Tian F, Tang H, Pu P, He Q, Duan L
Molecular medicine reports 2024 May;29(5)
Molecular medicine reports 2024 May;29(5)
Prognostic and immunotherapeutic implications of bilirubin metabolism-associated genes in lung adenocarcinoma.
Ren K, Ling X, Chen L, Li Z, Huang T
Journal of cellular and molecular medicine 2024 May;28(9):e18346
Journal of cellular and molecular medicine 2024 May;28(9):e18346
Glucose-modified BSA/procyanidin C1 NPs penetrate the blood-brain barrier and alleviate neuroinflammation in Alzheimer's disease models.
Duan L, Hao Z, Ji R, Li X, Wang H, Su Y, Guan F, Ma S
International journal of biological macromolecules 2024 May;268(Pt 1):131739
International journal of biological macromolecules 2024 May;268(Pt 1):131739
Heme oxygenase 1 (HO1) regulates autophagy and apoptosis via the PI3K/AKT/mTOR signaling pathway of yak Sertoli cells.
Yan Q, Wang Q, Nan J, Chen T, Wang J, Zhang Y, Yuan L
Theriogenology 2024 May;220:96-107
Theriogenology 2024 May;220:96-107
Unveiling the mechanisms of trichloroethylene hypersensitivity syndrome: Exploring the role of connexin 43 gap junctions in severe skin damage.
Jiao B, Jiang H, Liu S, Wang Y, Chen Y, Duan H, Niu Y, Shen M, Wang H, Dai Y
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 May;187:114594
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 May;187:114594
Identification of MACC1 as a potential biomarker for pulmonary arterial hypertension based on bioinformatics and machine learning.
Zhou X, Liang B, Lin W, Zha L
Computers in biology and medicine 2024 May;173:108372
Computers in biology and medicine 2024 May;173:108372
Dachengqi decoction ameliorates sepsis-induced liver injury by inhibiting the TGF-β1/Smad3 pathways.
Pan G, Wu Y, Liu Y, Zhou F, Li S, Yang S
Journal of traditional and complementary medicine 2024 May;14(3):256-265
Journal of traditional and complementary medicine 2024 May;14(3):256-265
Non-oxidized and oxidized flaxseed orbitides differently induce HepG2 cell apoptosis: involvement of cellular uptake and membrane death receptor DR4.
Peng C, Li J, Zhao A, Yu S, Zheng L, Deng ZY
Journal of the science of food and agriculture 2024 May;104(7):4296-4308
Journal of the science of food and agriculture 2024 May;104(7):4296-4308
Naringenin reduces oxidative stress and necroptosis, apoptosis, and pyroptosis in random-pattern skin flaps by enhancing autophagy.
Jiang S, Ma F, Lou J, Li J, Shang X, Li Y, Wu J, Xu S
European journal of pharmacology 2024 May 5;970:176455
European journal of pharmacology 2024 May 5;970:176455
Molecular, biological characterization and drug sensitivity of chidamide-resistant MCF7 cells.
Dai L, Zhang C, Gao W, Pan J, Huang S, Zhang Y, Cheng Y, Wang Y, Tao J, Wang H, Feng Z, Su C, Zhang Y
Translational cancer research 2024 May 31;13(5):2372-2386
Translational cancer research 2024 May 31;13(5):2372-2386
Endometrial stem cell-derived exosomes repair cisplatin-induced premature ovarian failure via Hippo signaling pathway.
Wang L, Wang L, Wang R, Xu T, Wang J, Cui Z, Cheng F, Wang W, Yang X
Heliyon 2024 May 30;10(10):e31639
Heliyon 2024 May 30;10(10):e31639
miR-92b-3p protects retinal tissues against DNA damage and apoptosis by targeting BTG2 in experimental myopia.
Liu J, Bao B, Li T, Yang Z, Du Y, Zhang R, Xin J, Hao J, Wang G, Bi H, Guo D
Journal of translational medicine 2024 May 28;22(1):511
Journal of translational medicine 2024 May 28;22(1):511
Circ_0001671 regulates prostate cancer progression through miR-27b-3p/BLM axis.
Yang L, Ruan Y, Chen B, Zhu Y, Xu H
Scientific reports 2024 May 28;14(1):12181
Scientific reports 2024 May 28;14(1):12181
miR-1202 regulates BPH-1 cell proliferation, apoptosis, and epithelial-to-mesenchymal transition through targeting HMGCL.
Wang Z, Yin X, Yang P, Gong B, Liu H
Acta biochimica et biophysica Sinica 2024 May 25;56(5):675-687
Acta biochimica et biophysica Sinica 2024 May 25;56(5):675-687
miR-122-5p Promotes Cowshed Particulate Matter2.5-Induced Apoptosis in NR8383 by Targeting COL4A1.
Sun Y, Sun K, Ma Z, Zhang X, Du X, Jia Y, Zhu Y, Inam M, Gao Y, Basang W
Toxics 2024 May 25;12(6)
Toxics 2024 May 25;12(6)
Salvianolic acid A alleviates H(2)O(2)-induced endothelial oxidative injury via miR-204-5p.
Qiao X, Cao S, Chen S, Guo Y, Chen N, Zheng Y, Jin B
Scientific reports 2024 May 24;14(1):11931
Scientific reports 2024 May 24;14(1):11931
IDH1 mutation produces R-2-hydroxyglutarate (R-2HG) and induces mir-182-5p expression to regulate cell cycle and tumor formation in glioma.
Zhao H, Meng L, Du P, Liao X, Mo X, Gong M, Chen J, Liao Y
Biological research 2024 May 17;57(1):30
Biological research 2024 May 17;57(1):30
Curdepsidone A Induces Intrinsic Apoptosis and Inhibits Protective Autophagy via the ROS/PI3K/AKT Signaling Pathway in HeLa Cells.
Xu S, Li Z, Xin X, An F
Marine drugs 2024 May 17;22(5)
Marine drugs 2024 May 17;22(5)
The Effects of Resveratrol and Apigenin on Jejunal Oxidative Injury in Ducks and on Immortalized Duck Intestinal Epithelial Cells Exposed to H(2)O(2).
Zhou N, Cao Y, Luo Y, Wang L, Li R, Di H, Gu T, Cao Y, Zeng T, Zhu J, Chen L, An D, Ma Y, Xu W, Tian Y, Lu L
Antioxidants (Basel, Switzerland) 2024 May 17;13(5)
Antioxidants (Basel, Switzerland) 2024 May 17;13(5)
FGF17 protects cerebral ischemia reperfusion-induced blood-brain barrier disruption via FGF receptor 3-mediated PI3K/AKT signaling pathway.
Huang WT, Chen XJ, Lin YK, Shi JF, Li H, Wu HD, Jiang RL, Chen S, Wang X, Tan XX, Chen KY, Wang P
European journal of pharmacology 2024 May 15;971:176521
European journal of pharmacology 2024 May 15;971:176521
Knockdown of trem2 promotes proinflammatory microglia and inhibits glioma progression via the JAK2/STAT3 and NF-κB pathways.
Yan Y, Bai S, Han H, Dai J, Niu L, Wang H, Dong Q, Yin H, Yuan G, Pan Y
Cell communication and signaling : CCS 2024 May 15;22(1):272
Cell communication and signaling : CCS 2024 May 15;22(1):272
Synergistic Effect of Flavonoids and Metformin on Protection of the Methylglyoxal-Induced Damage in PC-12 Neuroblastoma Cells: Structure-Activity Relationship and Potential Target.
Zhang D, He X, Wang T, Xing Y, Xiu Z, Bao Y, Dong Y
Molecules (Basel, Switzerland) 2024 May 14;29(10)
Molecules (Basel, Switzerland) 2024 May 14;29(10)
Mechanistic exploration and experimental validation of the Xiaochaihu decoction for the treatment of breast cancer by network pharmacology.
Liu Q, Luo Z, Sun M, Li W, Liu S
Aging 2024 May 13;16(9):7979-7999
Aging 2024 May 13;16(9):7979-7999
Withanolides from the active extract of Physalis angulate and their anti-hepatic fibrosis effects.
Wang FR, Peng ML, Zhu QF, Yu LL, Zhang LJ, Xu SY, Wang Q, Li J, He X, Liao SG, Ao JL, Xu GB
Journal of ethnopharmacology 2024 May 10;325:117830
Journal of ethnopharmacology 2024 May 10;325:117830
Pan-cancer analysis of LRRC59 with a focus on prognostic and immunological roles in hepatocellular carcinoma.
Pan B, Cheng J, Tan W, Wu X, Fan Q, Fan L, Jiang M, Yu R, Cheng X, Deng Y
Aging 2024 May 10;16(9):8171-8197
Aging 2024 May 10;16(9):8171-8197
Cytotoxic withanolides from the stems and leaves of Physalis ixocarpa.
Xiang K, Liu Y, Zhu R, Xu Y, Sun D, Yang Y, Yan Y, Yang B, Li H, Chen L
Food chemistry 2024 May 1;439:138136
Food chemistry 2024 May 1;439:138136
Augmented drug resistance of osteosarcoma cells within decalcified bone matrix scaffold: The role of glutamine metabolism.
Ren J, Zhao C, Sun R, Sun J, Lu L, Wu J, Li S, Cui L
International journal of cancer 2024 May 1;154(9):1626-1638
International journal of cancer 2024 May 1;154(9):1626-1638
Upregulation of tumor suppressor PIAS3 by Honokiol promotes tumor cell apoptosis via selective inhibition of STAT3 tyrosine 705 phosphorylation.
Fei Y, Zhang X, Wang X, Sun Y, He J, Liu X, Song Z, Li L, Qiu L, Qian Z, Zhou S, Liu X, Zhang H, Wang X
Journal of natural medicines 2024 Mar;78(2):285-295
Journal of natural medicines 2024 Mar;78(2):285-295
Lrg1 silencing attenuates ischemia-reperfusion renal injury by regulating autophagy and apoptosis through the TGFβ1- Smad1/5 signaling pathway.
Chen J, Zhang Z, Feng L, Liu W, Wang X, Chen H, Zou H
Archives of biochemistry and biophysics 2024 Mar;753:109892
Archives of biochemistry and biophysics 2024 Mar;753:109892
Mammalian STE20-like kinase 1 inhibits synoviocytes activation in rheumatoid arthritis through mitochondrial dysfunction mediated by SIRT3/mTOR axis.
Tan M, Mao J, Zheng J, Meng Y, Li J, Hao J, Shen H
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Mar;73(3):415-432
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 Mar;73(3):415-432
Akt/mTOR Pathway Agonist SC79 Inhibits Autophagy and Apoptosis of Oligodendrocyte Precursor Cells Associated with Neonatal White Matter Dysplasia.
Li Z, Zhang F, Huang L, Deng J, Pan Y, Xu T, Liu J, Gao N, Duan R, Shao C, Wu C, Wang M, Lu L
Neurochemical research 2024 Mar;49(3):670-683
Neurochemical research 2024 Mar;49(3):670-683
Alginate microspheres encapsulating hox transcript antisense RNA siRNA regulate the Hedgehog-Gli1 pathway to alleviate epidermal growth factor receptor tyrosine kinase inhibitors resistance.
Lu G, Zhong H, Gao J, Zhang Y
Journal of biomaterials applications 2024 Mar;38(8):877-889
Journal of biomaterials applications 2024 Mar;38(8):877-889
Muscone alleviates neuronal injury via increasing stress granules formation and reducing apoptosis in acute ischemic stroke.
Sun B, Luo J, Li Z, Chen D, Wang Q, Si W
Experimental neurology 2024 Mar;373:114678
Experimental neurology 2024 Mar;373:114678
SOD2 confers anlotinib resistance via regulation of mitochondrial damage in OSCC.
Li S, Cao C, Huang Z, Tang D, Chen J, Wang A, He Q
Oral diseases 2024 Mar;30(2):281-291
Oral diseases 2024 Mar;30(2):281-291
Homoharringtonine induces apoptosis of mammary carcinoma cells by inhibiting the AKT/mTOR signaling pathway.
Zhang X, Mei C, Liang Z, Zhi Y, Xu H, Wang H, Dong H
Veterinary and comparative oncology 2024 Mar;22(1):57-69
Veterinary and comparative oncology 2024 Mar;22(1):57-69
Golden bifid treatment regulates gut microbiota and serum metabolites to improve myocardial dysfunction in cecal ligation and puncture-induced sepsis mice.
Wu R, Xu J, Zeng H, Fan Y, Li H, Peng T, Xiao F
Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):167049
Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):167049
SETDB1-mediated CD147-K71 di-methylation promotes cell apoptosis in non-small cell lung cancer.
Shi MY, Wang Y, Shi Y, Tian R, Chen X, Zhang H, Wang K, Chen Z, Chen R
Genes & diseases 2024 Mar;11(2):978-992
Genes & diseases 2024 Mar;11(2):978-992
Research Note: Preliminary functional analysis of EGF-like domains of Eimeria tenella microneme protein 7 identified in sporozoites and merozoites.
Liu Q, Meng YJ, Mu BJ, Li J, Yu LM, Wang ZR, Fan QX, Zhu XQ, Gao WW
Poultry science 2024 Mar;103(3):103430
Poultry science 2024 Mar;103(3):103430
Copper Chaperone Atox1 Protected the Cochlea From Cisplatin by Regulating the Copper Transport Family and Cell Cycle.
Chen X, Xiang W, Li L, Xu K
International journal of toxicology 2024 Mar-Apr;43(2):134-145
International journal of toxicology 2024 Mar-Apr;43(2):134-145
Inhibition of OGFOD1 by FG4592 confers neuroprotection by activating unfolded protein response and autophagy after ischemic stroke.
Xie J, Zhang Y, Li B, Xi W, Wang Y, Li L, Liu C, Shen L, Han B, Kong Y, Yao H, Zhang Z
Journal of translational medicine 2024 Mar 7;22(1):248
Journal of translational medicine 2024 Mar 7;22(1):248
Mitochondria targeted biomimetic platform for chemo/photodynamic combination therapy against osteosarcoma.
Zhang F, Chen J, Luo W, Wen C, Mao W, Yang Y, Liu C, Xu Y, Chen W, Wen L
International journal of pharmaceutics 2024 Mar 5;652:123865
International journal of pharmaceutics 2024 Mar 5;652:123865
Mechanisms of vemurafenib-induced anti-tumor effects in ATC FRO cells.
Xu J, Xue D, Li Y, Zhou J, Chen H, Fan L
Heliyon 2024 Mar 30;10(6):e27629
Heliyon 2024 Mar 30;10(6):e27629
Synergistic dual cell therapy for atherosclerosis regression: ROS-responsive Bio-liposomes co-loaded with Geniposide and Emodin.
Li Z, Zhu H, Liu H, Liu D, Liu J, Zhang Y, Qin Z, Xu Y, Peng Y, Ruan L, Li J, He Y, Liu B, Long Y
Journal of nanobiotechnology 2024 Mar 25;22(1):129
Journal of nanobiotechnology 2024 Mar 25;22(1):129
Protective Effects and Mechanisms of Esculetin against H(2)O(2)-Induced Oxidative Stress, Apoptosis, and Pyroptosis in Human Hepatoma HepG2 Cells.
Luo Y, Chang T, Huang S, Xiang J, Tang S, Shen H
Molecules (Basel, Switzerland) 2024 Mar 22;29(7)
Molecules (Basel, Switzerland) 2024 Mar 22;29(7)
Enhancing precision medicine: a nomogram for predicting platinum resistance in epithelial ovarian cancer.
Li R, Xiong Z, Ma Y, Li Y, Yang Y, Ma S, Ha C
World journal of surgical oncology 2024 Mar 21;22(1):81
World journal of surgical oncology 2024 Mar 21;22(1):81
Extracellular vesicles secreted from mesenchymal stem cells ameliorate renal ischemia reperfusion injury by delivering miR-100-5p targeting FKBP5/AKT axis.
Chen G, Li X, Zhou X, Li Y, Yu H, Peng X, Bai X, Zhang C, Feng Z, Mei Y, Li L, Liu Y, Gou X, Jiang Y
Scientific reports 2024 Mar 20;14(1):6720
Scientific reports 2024 Mar 20;14(1):6720
Melatonin-Derived Carbon Dots with Free Radical Scavenging Property for Effective Periodontitis Treatment via the Nrf2/HO-1 Pathway.
Xin X, Liu J, Liu X, Xin Y, Hou Y, Xiang X, Deng Y, Yang B, Yu W
ACS nano 2024 Mar 19;18(11):8307-8324
ACS nano 2024 Mar 19;18(11):8307-8324
Histone lysine demethylase KDM5B facilitates proliferation and suppresses apoptosis in human acute myeloid leukemia cells through the miR-140-3p/BCL2 axis.
Huang J, Jin S, Guo R, Wu W, Yang C, Qin Y, Chen Q, He X, Qu J, Yang Z
RNA (New York, N.Y.) 2024 Mar 18;30(4):435-447
RNA (New York, N.Y.) 2024 Mar 18;30(4):435-447
FTO attenuates the cytotoxicity of cisplatin in KGN granulosa cell-like tumour cells by regulating the Hippo/YAP1 signalling pathway.
Wang R, Cheng F, Yang X
Journal of ovarian research 2024 Mar 15;17(1):62
Journal of ovarian research 2024 Mar 15;17(1):62
Jianpi Jiedu decoction reverses 5-fluorouracil resistance in colorectal cancer by suppressing the xCT/GSH/GPX4 axis to induce ferroptosis.
Ou QL, Cheng L, Chang YL, Liu JH, Zhang SF
Heliyon 2024 Mar 15;10(5):e27082
Heliyon 2024 Mar 15;10(5):e27082
CLPs-miR-103a-2-5p inhibits proliferation and promotes cell apoptosis in AML cells by targeting LILRB3 and Nrf2/HO-1 axis, regulating CD8 + T cell response.
Cen Q, Chen J, Guo J, Chen M, Wang H, Wu S, Zhang H, Xie X, Li Y
Journal of translational medicine 2024 Mar 14;22(1):278
Journal of translational medicine 2024 Mar 14;22(1):278
Global gene expression profiling of perirenal brown adipose tissue whitening in goat kids reveals novel genes linked to adipose remodeling.
Zhao L, Yang H, Li M, Xiao M, Li X, Cheng L, Cheng W, Chen M, Zhao Y
Journal of animal science and biotechnology 2024 Mar 14;15(1):47
Journal of animal science and biotechnology 2024 Mar 14;15(1):47
CircAKT3 alleviates postoperative cognitive dysfunction by stabilizing the feedback cycle of miR-106a-5p/HDAC4/MEF2C axis in hippocampi of aged mice.
Wang X, Tang X, Zhu P, Hua D, Xie Z, Guo M, Que M, Yan J, Li X, Xia Q, Luo X, Bi J, Zhao Y, Zhou Z, Li S, Luo A
Cellular and molecular life sciences : CMLS 2024 Mar 13;81(1):138
Cellular and molecular life sciences : CMLS 2024 Mar 13;81(1):138
Echinacoside alleviates glucocorticoid induce osteonecrosis of femoral head in rats through PI3K/AKT/FOXO1 pathway.
Huang LK, Zeng XS, Jiang ZW, Peng H, Sun F
Chemico-biological interactions 2024 Mar 1;391:110893
Chemico-biological interactions 2024 Mar 1;391:110893
Perfluorooctane sulfonate (PFOS) induces apoptosis and autophagy by inhibition of PI3K/AKT/mTOR pathway in human granulosa cell line KGN.
Gao M, Shen H, Li Q, Gu X, Jia T, Wang Y
Environmental pollution (Barking, Essex : 1987) 2024 Mar 1;344:123333
Environmental pollution (Barking, Essex : 1987) 2024 Mar 1;344:123333
The circRNA hsa-circ-0013561 regulates head and neck squamous cell carcinoma development via the miR-7-5p/PDK3 axis.
Tian K, Zheng L, Yuan T, Chen X, Chen Q, Xue X, Huang S, He W, Jin M, Zhang Y
Cancer cell international 2024 Mar 1;24(1):91
Cancer cell international 2024 Mar 1;24(1):91
Ssc-miR-429 expression proliles and functions on inducing Leydig cells apoptosis.
Tang Q, Zhang Y, Yue L, Ren H, Pan C
Theriogenology 2024 Mar 1;216:62-68
Theriogenology 2024 Mar 1;216:62-68
FTO demethylates regulates cell-cycle progression by controlling CCND1 expression in luteinizing goat granulosa cells.
Li D, Zhou L, Liu Z, Zhang Z, Mao W, Shi W, Zhu M, Wang F, Wan Y
Theriogenology 2024 Mar 1;216:20-29
Theriogenology 2024 Mar 1;216:20-29
VD(3)/VDR attenuates bisphenol A-induced impairment in mouse Leydig cells via regulation of autophagy.
Wang L, Zhuang J, Xue Z, Lu H, Zeng W, Zhang T
Journal of food science 2024 Jun;89(6):3858-3870
Journal of food science 2024 Jun;89(6):3858-3870
Beneficial effects of human umbilical cord mesenchymal stem cell (HUCMSC) transplantation on cyclophosphamide (CTX)-induced premature ovarian failure (POF) in Tibetan miniature pigs.
Cai J, Liang X, Sun Y, Bao S
Transplant immunology 2024 Jun;84:102051
Transplant immunology 2024 Jun;84:102051
Alpha-lipoic Acid Prevents Bone Loss in Type 2 Diabetes and Postmenopausal Osteoporosis Coexisting Conditions by Modulating the YAP/Glut4 Pathway.
Xu L, Zhang C, Bao J, Han G, Wang C, Cai Y, Xu G, Sun H, Liu M
Cell biochemistry and biophysics 2024 Jun;82(2):669-685
Cell biochemistry and biophysics 2024 Jun;82(2):669-685
Dual-specificity phosphatase 26 protects against kidney injury caused by ischaemia-reperfusion through restraint of TAK1-JNK/p38-mediated apoptosis and inflammation of renal tubular epithelial cells.
Xiang H, Li Z, Li Y, Zheng J, Dou M, Xue W, Wu X
Toxicology and applied pharmacology 2024 Jun;487:116954
Toxicology and applied pharmacology 2024 Jun;487:116954
Photodynamic therapy inhibits cancer progression and induces ferroptosis and apoptosis by targeting P53/GPX4/SLC7A11 signaling pathways in cholangiocarcinoma.
Yan X, Li Z, Chen H, Yang F, Tian Q, Zhang Y
Photodiagnosis and photodynamic therapy 2024 Jun;47:104104
Photodiagnosis and photodynamic therapy 2024 Jun;47:104104
Effects of Hericium erinaceus polysaccharide in porcine IPEC-J2 intestinal epithelial cells against apoptosis induced by oxidative stress.
Li J, Mo JR, Hu SY, Dong X, Li JW, Yang LY, Wu YJ
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2024 Jun;280:109902
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2024 Jun;280:109902
Structural characterization and improves cognitive disorder in ageing mice of a glucomannan from Dendrobium huoshanense.
Zhang X, Ge R, Wu J, Cai X, Deng G, Lv J, Ma M, Yu N, Yao L, Peng D
International journal of biological macromolecules 2024 Jun;269(Pt 1):131995
International journal of biological macromolecules 2024 Jun;269(Pt 1):131995
The Effect of Selenium on Endometrial Repair in Goats with Endometritis at High Cortisol Levels.
Li H, Yuan C, Wang H, Cui L, Liu K, Guo L, Li J, Dong J
Biological trace element research 2024 Jun;202(6):2564-2576
Biological trace element research 2024 Jun;202(6):2564-2576
POSTN knockdown suppresses IL-1β-induced inflammation and apoptosis of nucleus pulposus cells via inhibiting the NF-κB pathway and alleviates intervertebral disc degeneration.
Wang Z, Zhu D, Yang F, Chen H, Kang J, Liu W, Lin A, Kang X
Journal of cell communication and signaling 2024 Jun;18(2):e12030
Journal of cell communication and signaling 2024 Jun;18(2):e12030
12-O-deacetyl-phomoxanthone A inhibits ovarian tumor growth and metastasis by downregulating PDK4.
Yang C, Xing S, Wei X, Lu J, Zhao G, Ma X, Dai Z, Liang X, Huang W, Liu Y, Jiang X, Zhu D
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jun;175:116736
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jun;175:116736
Curcuma wenyujin rhizomes extract ameliorates lipid accumulation.
Wang H, Chen L, Zhang R, Zhang G, Liu J, Guo F
Fitoterapia 2024 Jun;175:105957
Fitoterapia 2024 Jun;175:105957
The mechanism of curcumin to protect mouse ovaries from oxidative damage by regulating AMPK/mTOR mediated autophagy.
Duan H, Yang S, Yang S, Zeng J, Yan Z, Zhang L, Ma X, Dong W, Zhang Y, Zhao X, Hu J, Xiao L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155468
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155468
Glucose regulates the HMGB1 signaling pathway through SIRT1 in glioma.
Wang Y, Wang S, Wang Y, Wang C, Tang Y, Zhang C, Hou S, Yu D, Lin N
Cellular signalling 2024 Jun;118:111137
Cellular signalling 2024 Jun;118:111137
Experimental verification about treatment of Bu-Shen-Yi-Jing-Fang in Alzheimer's disease by the analysis of the feasible signaling pathway of network pharmacology.
Hu Y, Hao R, Li D, Lu Y, Yu G
BMC complementary medicine and therapies 2024 Jun 8;24(1):222
BMC complementary medicine and therapies 2024 Jun 8;24(1):222
Development and Investigation of an Innovative 3D Biohybrid Based on Collagen and Silk Sericin Enriched with Flavonoids for Potential Wound Healing Applications.
Sleiman L, Lazăr Popa AD, Albu-Kaya M, Marin MM, Kaya DA, Vasile OR, Dinescu S
Polymers 2024 Jun 8;16(12)
Polymers 2024 Jun 8;16(12)
Increasing GSH-Px Activity and Activating Wnt Pathway Promote Fine Wool Growth in FGF5-Edited Sheep.
Xu XL, Wu SJ, Qi SY, Chen MM, Liu ZM, Zhang R, Zhao Y, Liu SQ, Zhou WD, Zhang JL, Zhang XS, Deng SL, Yu K, Li Y, Lian ZX
Cells 2024 Jun 5;13(11)
Cells 2024 Jun 5;13(11)
Oxidative stress-induced EGR1 upregulation promotes NR4A3-mediated nucleus pulposus cells apoptosis in intervertebral disc degeneration.
Zheng SK, Zhao XK, Wu H, He DW, Xiong L, Cheng XG
Aging 2024 Jun 28;16(12):10216-10238
Aging 2024 Jun 28;16(12):10216-10238
Potential Molecular Mechanism of Illicium simonsii Maxim Petroleum Ether Fraction in the Treatment of Hepatocellular Carcinoma.
Zou S, Wu Y, Wen M, Liu J, Chen M, Yuan J, Zhou B
Pharmaceuticals (Basel, Switzerland) 2024 Jun 19;17(6)
Pharmaceuticals (Basel, Switzerland) 2024 Jun 19;17(6)
RARRES1 identified by comprehensive bioinformatic analysis and experimental validation as a promising biomarker in Skin Cutaneous Melanoma.
Liu M, Bai R, Zhang G, Liu X, Wang Z, He K, Gan X, Zhou X, Yin P, Zheng Y, Wang G
Scientific reports 2024 Jun 19;14(1):14113
Scientific reports 2024 Jun 19;14(1):14113
Bradykinin protects nucleus pulposus cells from tert-butyl hydroperoxide-induced damage and delays intervertebral disc degeneration.
Qiu X, Ma C, Luo Z, Zhang Y, Kang J, Zhu D, Wang Z, Li L, Wei Z, Wang Z, Kang X
International immunopharmacology 2024 Jun 15;134:112161
International immunopharmacology 2024 Jun 15;134:112161
S100A6 Regulates nucleus pulposus cell apoptosis via Wnt/β-catenin signaling pathway: an in vitro and in vivo study.
Yang F, Duan Y, Li Y, Zhu D, Wang Z, Luo Z, Zhang Y, Zhang G, He X, Kang X
Molecular medicine (Cambridge, Mass.) 2024 Jun 14;30(1):87
Molecular medicine (Cambridge, Mass.) 2024 Jun 14;30(1):87
Neurokinin-1 receptor antagonist aprepitant regulates autophagy and apoptosis via ROS/JNK in intrahepatic cholangiocarcinoma.
Yang Y, Cao X, Wang Y, Wu X, Zhou P, Miao L, Deng X
Liver international : official journal of the International Association for the Study of the Liver 2024 Jul;44(7):1651-1667
Liver international : official journal of the International Association for the Study of the Liver 2024 Jul;44(7):1651-1667
MicroRNA-322-5p targeting Smurf2 regulates the TGF-β/Smad pathway to protect cardiac function and inhibit myocardial infarction.
Guo L, Li K, Ma Y, Niu H, Li J, Shao X, Li N, Sun Y, Wang H
Human cell 2024 Jul;37(4):972-985
Human cell 2024 Jul;37(4):972-985
A novel p55PIK signaling peptide inhibitor alleviates neuroinflammation via the STAT3/NF-kB signaling pathway in experimental stroke.
Liu Y, Leng C, Li Y, Zhou M, Ye X, Li C, Xia X, Sun B, Shu X, Liu W
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2024 Jul;33(7):107736
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2024 Jul;33(7):107736
Overexpressed FKBP5 mediates colorectal cancer progression and sensitivity to FK506 treatment via the NF-κB signaling pathway.
Liu T, Wang C, Xia Z
The FEBS journal 2024 Jul;291(14):3128-3146
The FEBS journal 2024 Jul;291(14):3128-3146
Ginkgolic acids induce liver injury in mice through cell cycle arrest and immune stress under specific condition.
Yang Z, Fang X, Zhang Y, Bai Y, Zhao L, Zhou X
Toxicon : official journal of the International Society on Toxinology 2024 Jul;245:107788
Toxicon : official journal of the International Society on Toxinology 2024 Jul;245:107788
Anthocyanins from blueberry ameliorated arsenic-induced memory impairment, oxidative stress, and mitochondrial-biosynthesis imbalance in rat hippocampal neurons.
Ma X, Liu Y, Ding B, Lu S, Ni B, Chen Y, Yang L, Liu Y, Zhang Y, Wang Y, Yang Y, Liu X
Cellular signalling 2024 Jul;119:111177
Cellular signalling 2024 Jul;119:111177
The HSP90AA1 gene is involved in heat stress responses and its functional genetic polymorphisms are associated with heat tolerance in Holstein cows.
Hu L, Fang H, Abbas Z, Luo H, Brito LF, Wang Y, Xu Q
Journal of dairy science 2024 Jul;107(7):5132-5149
Journal of dairy science 2024 Jul;107(7):5132-5149
Emodin alleviates intestinal ischemia-reperfusion injury through antioxidant stress, anti-inflammatory responses and anti-apoptosis effects via Akt-mediated HO-1 upregulation.
Liu Y, Ji T, Jiang H, Chen M, Liu W, Zhang Z, He X
Journal of inflammation (London, England) 2024 Jul 9;21(1):25
Journal of inflammation (London, England) 2024 Jul 9;21(1):25
HOXC4 promotes proliferation of pancreatic cancer cells by increasing LDHA-mediated glycolysis.
Zhang H, Han B, Tian S, Gong Y, Chen L, Liu L
Aging 2024 Jul 9;16(13):11103-11116
Aging 2024 Jul 9;16(13):11103-11116
A black phosphorus nanosheet-based RNA delivery system for prostate cancer therapy by increasing the expression level of tumor suppressor gene PTEN via CeRNA mechanism.
Su S, Liu L, Fu Q, Ma M, Yang N, Pan T, Geng S, Yu XF, Zhu J
Journal of nanobiotechnology 2024 Jul 4;22(1):391
Journal of nanobiotechnology 2024 Jul 4;22(1):391
Eurochevalierines A-I, Sesquiterpene Alkaloid Hybrids with Anti-Triple Negative Breast Cancer Activity from Penicillium sp. HZ-5.
Zhang Y, Li Q, Zhang J, Chen M, Li X, Qiao Y, Wang K, Qi C, Zhang Y
Journal of agricultural and food chemistry 2024 Jul 31;72(30):16801-16811
Journal of agricultural and food chemistry 2024 Jul 31;72(30):16801-16811
Paeoniflorin Promotes Ovarian Development in Mice by Activating Mitophagy and Preventing Oxidative Stress.
Xi H, Wang Z, Li M, Duan X, Li Y
International journal of molecular sciences 2024 Jul 30;25(15)
International journal of molecular sciences 2024 Jul 30;25(15)
The miR-15b-5p/miR-379-3p-FOXO axis regulates cell cycle and apoptosis in scleral remodeling during experimental myopia.
Zhang R, Wen Y, Liu J, Hao J, Peng Y, Zhang M, Xie Y, Yang Z, Yin X, Shi Y, Bi H, Guo D
Journal of translational medicine 2024 Jul 30;22(1):710
Journal of translational medicine 2024 Jul 30;22(1):710
HMGA1 promotes the progression of esophageal squamous cell carcinoma by elevating TKT-mediated upregulation of pentose phosphate pathway.
Liu MJ, Zhao Y, Li QT, Lei XY, He KY, Guo JR, Yang JY, Yan ZH, Wu DH, Zhang L, Jian YP, Xu ZX
Cell death & disease 2024 Jul 30;15(7):541
Cell death & disease 2024 Jul 30;15(7):541
Intragland Expression of the Shh Gene Alleviates Irradiation-Induced Salivary Gland Injury through Microvessel Protection and the Regulation of Oxidative Stress.
Hu M, Hu L, Yang T, Zhou B, Feng X, Fan Z, Shan Z
Antioxidants (Basel, Switzerland) 2024 Jul 26;13(8)
Antioxidants (Basel, Switzerland) 2024 Jul 26;13(8)
Activation of ARP2/3 and HSP70 Expression by Lipoteichoic Acid: Potential Bidirectional Regulation of Apoptosis in a Mastitis Inflammation Model.
Fang B, Yang T, Chen Y, Duan Z, Hu J, Wang Q, He Y, Zhang Y, Dong W, Zhang Q, Zhao X
Biomolecules 2024 Jul 25;14(8)
Biomolecules 2024 Jul 25;14(8)
Enhanced therapeutic impact of Shikonin-encapsulated exosomes in the inhibition of colorectal cancer progression.
Lu Y, Zhou H, Han C, Gong Y, Li Y, Xia Y, Liang B, Yang H, Wang Z
Nanotechnology 2024 Jul 23;35(41)
Nanotechnology 2024 Jul 23;35(41)
Paeonia lactiflora Pall. ameliorates acetaminophen-induced oxidative stress and apoptosis via inhibiting the PKC-ERK pathway.
Li Y, Deng X, Hu Q, Chen Y, Zhang W, Qin X, Wei F, Lu X, Ma X, Zeng J, Efferth T
Journal of ethnopharmacology 2024 Jul 15;329:118107
Journal of ethnopharmacology 2024 Jul 15;329:118107
PRAME promotes proliferation of multiple myeloma cells through CTMP/Akt/p21/CCND3 axis by ubiquitinating CTMP and p21.
Sun K, Yang L, Wang F, Liu Y, Xu N, Shi ZY, Chen WM, Li K, Qin YZ
Heliyon 2024 Jul 15;10(13):e34094
Heliyon 2024 Jul 15;10(13):e34094
CHRDL2 activates the PI3K/AKT pathway to ameliorate glucocorticoid-induced damages to bone microvascular endothelial cells (BMECs).
Huang X, Jie S, Li W, Liu C
Heliyon 2024 Jul 15;10(13):e33867
Heliyon 2024 Jul 15;10(13):e33867
Isorhamnetin inhibits hypertrophic scar formation through TGF-β1/Smad and TGF-β1/CREB3L1 signaling pathways.
Wu J, Song Y, Wang J, Wang T, Yang L, Shi Y, Song B, Yu Z
Heliyon 2024 Jul 15;10(13):e33802
Heliyon 2024 Jul 15;10(13):e33802
Diallyl trisulfide induces pyroptosis and impairs lung CSC-like properties by activating the ROS/Caspase 1 signaling pathway.
Xie C, Zhou X, Chen W, Ren D, Li X, Jiang R, Zhong C, Zhu J
Chemico-biological interactions 2024 Jul 1;397:111083
Chemico-biological interactions 2024 Jul 1;397:111083
Copper exposure induces mitochondrial dysfunction and hepatotoxicity via the induction of oxidative stress and PERK/ATF4 -mediated endoplasmic reticulum stress.
Li M, Tang S, Velkov T, Shen J, Dai C
Environmental pollution (Barking, Essex : 1987) 2024 Jul 1;352:124145
Environmental pollution (Barking, Essex : 1987) 2024 Jul 1;352:124145
Characterization and safety assessment of bamboo shoot shell cellulose nanofiber: Prepared by acidolysis combined with dynamic high-pressure microfluidization.
Luo X, Wang Q, Liu W, Wu Y, Yang J, Chen P, Zhuang W, Zheng Y
Carbohydrate polymers 2024 Jul 1;335:122082
Carbohydrate polymers 2024 Jul 1;335:122082
Oridonin suppresses the growth of glioblastoma cells via inhibiting Hippo/YAP axis.
Wang C, Zhang Y, Jiang Q, Chen S, Zhang L, Qiu H
Archives of biochemistry and biophysics 2024 Jan;751:109845
Archives of biochemistry and biophysics 2024 Jan;751:109845
Selenomethionine protects the liver from dietary deoxynivalenol exposure via Nrf2/PPARγ-GPX4-ferroptosis pathway in mice.
Fan S, Lin L, Li P, Tian H, Shen J, Zhou L, Zhao Q, Zhang J, Qin Y, Tang C
Toxicology 2024 Jan;501:153689
Toxicology 2024 Jan;501:153689
The lack of homology domain and leucine rich repeat protein phosphatase 2 ameliorates visual impairment in rats with diabetic retinopathy through regulation of the AKT-GSK-3β-Nrf2 signal cascade.
Chen L, Qi E, Liu X, Cui L, Fan X, Wei T, Hu Y
Toxicology and applied pharmacology 2024 Jan;482:116766
Toxicology and applied pharmacology 2024 Jan;482:116766
Circular RNA circXPO1 Promotes Multiple Myeloma Progression by Regulating miR-495-3p/DNA Damage-Induced Transcription 4 Axis.
Li F, Liu J, Miao J, Hong F, Liu R, Lv Y, Yang Y, He A, Wang J
DNA and cell biology 2024 Jan;43(1):39-55
DNA and cell biology 2024 Jan;43(1):39-55
miRNA-211-5p inhibition enhances the protective effect of hucMSC-derived exosome in Aβ(1-40) -induced SH-SY5Y cells by increasing NEP expression.
Chen H, Huang Z, Lei A, Yu X, Shen M, Wu D
Journal of biochemical and molecular toxicology 2024 Jan;38(1):e23624
Journal of biochemical and molecular toxicology 2024 Jan;38(1):e23624
IGF-I protects porcine granulosa cells from hypoxia-induced apoptosis by promoting homologous recombination repair through the PI3K/AKT/E2F8/RAD51 pathway.
Liu Z, Feng C, Li C, He T, Wu G, Fu C, Li H, Shen M, Liu H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan;38(1):e23332
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan;38(1):e23332
Injectable dexamethasone-loaded peptide hydrogel for therapy of radiation-induced ototoxicity by regulating the mTOR signaling pathway.
Liu J, Zhu L, Bao Y, Du Z, Shi L, Hong X, Zou Z, Peng G
Journal of controlled release : official journal of the Controlled Release Society 2024 Jan;365:729-743
Journal of controlled release : official journal of the Controlled Release Society 2024 Jan;365:729-743
pH-driven preparation of pea protein isolate-curcumin nanoparticles effectively enhances antitumor activity.
Ren J, Wu H, Lu Z, Qin Q, Jiao X, Meng G, Liu W, Li G
International journal of biological macromolecules 2024 Jan;256(Pt 1):128383
International journal of biological macromolecules 2024 Jan;256(Pt 1):128383
The P38MAPK/ATF2 signaling pathway is involved in PND in mice.
Zhu M, Long S, Tao Y, Zhang Z, Zhou Z, Wang X, Chen W
Experimental brain research 2024 Jan;242(1):109-121
Experimental brain research 2024 Jan;242(1):109-121
Extracellular ATP (eATP) inhibits the progression of endometriosis and enhances the immune function of macrophages.
Zhou L, Cai E, Liu H, Cheng H, Ye X, Zhu H, Chang X
Biochimica et biophysica acta. Molecular basis of disease 2024 Jan;1870(1):166895
Biochimica et biophysica acta. Molecular basis of disease 2024 Jan;1870(1):166895
Asperosaponin VI facilitates the regeneration of skeletal muscle injury by suppressing GSK-3β-mediated cell apoptosis.
Yang X, Liang J, Shu Y, Wei L, Wen C, Luo H, Ma L, Qin T, Wang B, Zeng S, Liu Y, Zhou C
Journal of cellular biochemistry 2024 Jan;125(1):115-126
Journal of cellular biochemistry 2024 Jan;125(1):115-126
Zinc finger protein 831 promotes apoptosis and enhances chemosensitivity in breast cancer by acting as a novel transcriptional repressor targeting the STAT3/Bcl2 signaling pathway.
Fan J, Zhang Z, Chen H, Chen D, Yuan W, Li J, Zeng Y, Zhou S, Zhang S, Zhang G, Xiong J, Zhou L, Xu J, Liu W, Xu Y
Genes & diseases 2024 Jan;11(1):430-448
Genes & diseases 2024 Jan;11(1):430-448
Drp1 regulated PINK1-dependent mitophagy protected duck follicular granulosa cells from acute heat stress injury.
Yang C, Luo P, Yang YT, Fu XL, Li BX, Shen X, Xu DN, Huang YM, Tian YB, Liu WJ
Poultry science 2024 Jan;103(1):103247
Poultry science 2024 Jan;103(1):103247
Hsa_circ_0013561 promotes progression of nasopharyngeal carcinoma by activating JAK2/STAT3 signaling pathway.
Kaisai T, Mantang Z, Tailei Y, Liying Z, Xiaoping C, Mingming J, Yi Z
Brazilian journal of otorhinolaryngology 2024 Jan-Feb;90(1):101362
Brazilian journal of otorhinolaryngology 2024 Jan-Feb;90(1):101362
A novel lncRNA LOC105613571 binding with BDNF in pituitary promotes gonadotropin secretion by AKT/ERK-mTOR pathway in sheep associated with prolificacy.
Cai Y, Yang H, Wan Z, Chen PY, Wang ZB, Guo JJ, Wang D, Wang F, Zhang Y
BioFactors (Oxford, England) 2024 Jan-Feb;50(1):58-73
BioFactors (Oxford, England) 2024 Jan-Feb;50(1):58-73
Polyphyllin II (PPII) Enhances the Sensitivity of Multidrug-resistant A549/DDP Cells to Cisplatin by Modulating Mitochondrial Energy Metabolism.
Peng L, Yang R, Wang Z, Jian H, Tan X, Li J, He Z, Huang R, Zeng P, Gao W
In vivo (Athens, Greece) 2024 Jan-Feb;38(1):213-225
In vivo (Athens, Greece) 2024 Jan-Feb;38(1):213-225
Icariin protects testicular damage in streptozotocin-induced diabetic rats through regulation of glycolysis pathway.
Liu F, Liao B, Ling YL, Meng XZ, Wang JL, Hu LL, Luo XQ, Yang FL
International journal of immunopathology and pharmacology 2024 Jan-Dec;38:3946320241279525
International journal of immunopathology and pharmacology 2024 Jan-Dec;38:3946320241279525
Corosolic Acid Induced Apoptosis via Upregulation of Bax/Bcl-2 Ratio and Caspase-3 Activation in Cholangiocarcinoma Cells.
Jedram O, Maphanao P, Karnchanapandh K, Mahalapbutr P, Thanan R, Sakonsinsiri C
ACS omega 2024 Jan 9;9(1):1278-1286
ACS omega 2024 Jan 9;9(1):1278-1286
Celastrol Alleviates Mitochondrial Oxidative Stress and Brain Injury After Intracerebral Hemorrhage by Promoting OPA1-Dependent Mitochondrial Fusion.
Diao C, Yang Z, Hu Q, Yao P, Qu X, Li C, Zhang S, Zhou J
Neuroscience 2024 Jan 9;536:79-91
Neuroscience 2024 Jan 9;536:79-91
Mechanism study of oleanolic acid derivative, K73-03, inducing cell apoptosis in hepatocellular carcinoma.
Wang J, Ma C, Tang Z, Sun Z, Qaed E, Chi X, Wang J, Jamalat Y, Geng Z, Tang Z, Yao Q
Cancer cell international 2024 Jan 7;24(1):17
Cancer cell international 2024 Jan 7;24(1):17
Tetrahydroalstonine possesses protective potentials on palmitic acid stimulated SK-N-MC cells by suppression of Aβ1-42 and tau through regulation of PI3K/Akt signaling pathway.
Chen K, Yu G
European journal of pharmacology 2024 Jan 5;962:176251
European journal of pharmacology 2024 Jan 5;962:176251
Unlocking the role of EIF5A: A potential diagnostic marker regulating the cell cycle and showing negative correlation with immune infiltration in lung adenocarcinoma.
Yang Z, Yuan H, He H, Qi S, Zhu X, Hu X, Jin M, Zhang XX, Yuan ZG
International immunopharmacology 2024 Jan 5;126:111227
International immunopharmacology 2024 Jan 5;126:111227
Protective effect of apelin-13 on ventilator-induced acute lung injury.
Lian S, Zhang X, Shen Y, He S, Chen Z, Zhou L, Jiang W
Molecular biology reports 2024 Jan 4;51(1):74
Molecular biology reports 2024 Jan 4;51(1):74
Adipose-derived stem cell exosomes promote tumor characterization and immunosuppressive microenvironment in breast cancer.
Zhu Q, Cao Y, Yuan J, Hu Y
Cancer immunology, immunotherapy : CII 2024 Jan 31;73(2):39
Cancer immunology, immunotherapy : CII 2024 Jan 31;73(2):39
Fibroblast growth factor 21 alleviates diabetes-induced cognitive decline.
Zhang X, Zheng H, Ni Z, Shen Y, Wang D, Li W, Zhao L, Li C, Gao H
Cerebral cortex (New York, N.Y. : 1991) 2024 Jan 31;34(2)
Cerebral cortex (New York, N.Y. : 1991) 2024 Jan 31;34(2)
Huaier suppresses cisplatin resistance in non-small cell lung cancer by inhibiting the JNK/JUN/IL-8 signaling pathway.
Jin H, Liu C, Liu X, Wang H, Zhang Y, Liu Y, Li J, Yu Z, Liu HX
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117270
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117270
Jianpi Shengqing Huazhuo Formula improves abnormal glucose and lipid metabolism in obesity by regulating mitochondrial biogenesis.
Wang W, Chen S, Xu S, Liao G, Li W, Yang X, Li T, Zhang H, Huang H, Zhou Y, Pan H, Lin C
Journal of ethnopharmacology 2024 Jan 30;319(Pt 1):117102
Journal of ethnopharmacology 2024 Jan 30;319(Pt 1):117102
Uncovering the Therapeutic Potential of Phosphocreatine in Diabetic Retinopathy: Mitigating Mitochondrial Dysfunction and Apoptosis via JAK2/STAT3 Signaling Pathway.
Qaed E, Alyafeai E, Al-Maamari A, Zaky MY, Almoiliqy M, Al-Hamyari B, Qaid A, Yafei S, Aldahmash W, Mahyoub MA, Wang F, Kang L, Tang Z, Zhang J
Journal of molecular neuroscience : MN 2024 Jan 17;74(1):11
Journal of molecular neuroscience : MN 2024 Jan 17;74(1):11
Downregulation of homeobox A1 in human granulosa cells is involved in diminished ovarian reserve through promoting cell apoptosis and mitochondrial dysfunction.
Chen Q, Chen Q, Song Y, Xiang Y, Li Q, Sang Y, Zhang L, Bai L, Zhu Y
Molecular and cellular endocrinology 2024 Jan 15;580:112084
Molecular and cellular endocrinology 2024 Jan 15;580:112084
Aluminum-maltol induced oxidative stress and reduced AMPK activity via BCK-related energy supply failure in C6 cell.
Wang Y, Yu Q, Liu S, Liu C, Ju Y, Song Q, Cheng D
Ecotoxicology and environmental safety 2024 Jan 15;270:115831
Ecotoxicology and environmental safety 2024 Jan 15;270:115831
Fluorochloridone induces mitochondrial dysfunction and apoptosis in primary goat Sertoli cells.
Li Y, Li L, Xiong W, Duan X, Xi H
Theriogenology 2024 Jan 15;214:192-200
Theriogenology 2024 Jan 15;214:192-200
Therapeutic potential of anti-PIK3CG treatment for multiple myeloma via inhibiting c-Myc pathway.
Di X, Pan Y, Yan J, Liu J, Wen D, Jiang H, Zhang S
Heliyon 2024 Jan 15;10(1):e23165
Heliyon 2024 Jan 15;10(1):e23165
Bruceine B Displays Potent Antimyeloma Activity by Inducing the Degradation of the Transcription Factor c-Maf.
Li H, Zhu X, Sun Z, Wang Q, Song S, Xu Y, He G, Mao X
ACS pharmacology & translational science 2024 Jan 12;7(1):176-185
ACS pharmacology & translational science 2024 Jan 12;7(1):176-185
Targeted Degradation of PCSK9 In Vivo by Autophagy-Tethering Compounds.
Ouyang Z, Ma M, Zhang Z, Wu H, Xue Y, Jian Y, Yin K, Yu S, Zhao C, Guo W, Gu X
Journal of medicinal chemistry 2024 Jan 11;67(1):433-449
Journal of medicinal chemistry 2024 Jan 11;67(1):433-449
E3 ligase TRIM65 alleviates intestinal ischemia/reperfusion injury through inhibition of TOX4-mediated apoptosis.
Huang Y, Chen T, Jiang M, Xiong C, Mei C, Nie J, Zhang Q, Zhu Q, Huang X, Zhang X, Li Y
Cell death & disease 2024 Jan 11;15(1):29
Cell death & disease 2024 Jan 11;15(1):29
Chinese herbal medicine alleviates autophagy and apoptosis in ovarian granulosa cells induced by testosterone through PI3K/AKT1/FOXO1 pathway.
Hu W, Xie N, Pan M, Zhang Q, Zhang H, Wang F, Qu F
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117025
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117025
Hesperetin promotes bladder cancer cells death via the PI3K/AKT pathway by network pharmacology and molecular docking.
Lv Y, Liu Z, Deng L, Xia S, Mu Q, Xiao B, Xiu Y, Liu Z
Scientific reports 2024 Jan 10;14(1):1009
Scientific reports 2024 Jan 10;14(1):1009
MitomiR-1736-3p regulates copper-induced mitochondrial pathway apoptosis by inhibiting AATF in chicken hepatocytes.
Li Y, Zhong G, Li L, Li T, Li H, Li Y, Zhang H, Pan J, Hu L, Liao J, Yu W, Tang Z
The Science of the total environment 2024 Jan 1;906:167825
The Science of the total environment 2024 Jan 1;906:167825
Parkin-mediated mitophagy is a potential treatment for oxaliplatin-induced peripheral neuropathy.
Zhao G, Zhang T, Li J, Li L, Chen P, Zhang C, Li K, Cui C
American journal of physiology. Cell physiology 2024 Jan 1;326(1):C214-C228
American journal of physiology. Cell physiology 2024 Jan 1;326(1):C214-C228
ACE2 activation alleviates sepsis-induced cardiomyopathy by promoting MasR-Sirt1-mediated mitochondrial biogenesis.
Wan TT, Li Y, Li JX, Xiao X, Liu L, Li HH, Guo SB
Archives of biochemistry and biophysics 2024 Feb;752:109855
Archives of biochemistry and biophysics 2024 Feb;752:109855
GANT61, an inhibitor of Gli1, inhibits the proliferation and migration of hepatocellular carcinoma cells.
Liu BW, Cao JL, Wang Y, Zhao X, Zeng Q, Liu WP, Zhang JH, Fan YZ, Dou J
Journal of investigative medicine : the official publication of the American Federation for Clinical Research 2024 Feb;72(2):181-192
Journal of investigative medicine : the official publication of the American Federation for Clinical Research 2024 Feb;72(2):181-192
Oncogenic lncRNA FAM215A promotes the malignant cell phenotypes of acute myeloid leukemia (AML) cell lines.
Li L, Xin L, Yang X, Zou Z
Journal of molecular histology 2024 Feb;55(1):97-108
Journal of molecular histology 2024 Feb;55(1):97-108
Synergistic effect of adavosertib and fimepinostat on acute myeloid leukemia cells by enhancing the induction of DNA damage.
Wang Y, Lin X, Wang Y, Wang G
Investigational new drugs 2024 Feb;42(1):70-79
Investigational new drugs 2024 Feb;42(1):70-79
Tetraarsenic tetrasulfide triggers ROS-induced apoptosis and ferroptosis in B-cell acute lymphoblastic leukaemia by targeting HK2.
Bai W, Liu D, Cheng Q, Yang X, Zhu L, Qin L, Fang J
Translational oncology 2024 Feb;40:101850
Translational oncology 2024 Feb;40:101850
Serabelisib regulates GSDMD-mediated pyroptosis, apoptosis and migration of hepatoma cells via the PI3K/Akt/E-cadherin signaling pathway.
Li M, Huang Z, Zhou Y
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2024 Feb;33(2):171-181
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2024 Feb;33(2):171-181
Iron overload suppresses hippocampal neurogenesis in adult mice: Implication for iron dysregulation-linked neurological diseases.
Li J, Ding Y, Zhang J, Zhang Y, Cui Y, Zhang Y, Chang S, Chang YZ, Gao G
CNS neuroscience & therapeutics 2024 Feb;30(2):e14394
CNS neuroscience & therapeutics 2024 Feb;30(2):e14394
In situ generation of hybrid alginate hydrogels for enhanced breast tumor ferrotherapy through multiplex magnifying redox imbalances.
Zhuang H, Xue P, Shao S, Zeng X, Yan S
International journal of biological macromolecules 2024 Feb;258(Pt 2):128952
International journal of biological macromolecules 2024 Feb;258(Pt 2):128952
Discovery of Novel Marine-Derived Phidiandine/Lipoic Acid Hybrid as a Potential Anti-Atherosclerosis Agent: Design, Synthesis and in Vitro/in Vivo Evaluation.
Liu SJ, Zhong YN, Cheng ZQ, Meng N, Zhang J, Jiang CS
Chemistry & biodiversity 2024 Feb;21(2):e202301371
Chemistry & biodiversity 2024 Feb;21(2):e202301371
GK921, a transglutaminase inhibitor, strengthens the antitumor effect of cisplatin on pancreatic cancer cells by inhibiting epithelial-to-mesenchymal transition.
Li M, Wang X, Chen X, Hong J, Du Y, Song D
Biochimica et biophysica acta. Molecular basis of disease 2024 Feb;1870(2):166925
Biochimica et biophysica acta. Molecular basis of disease 2024 Feb;1870(2):166925
The augmentation of cytotoxic immune cell functionality through physical exertion bolsters the potency of chemotherapy in models of mammary carcinoma.
Qin B, He Z, Xie L, Feng S, Ye J, Gui J, Sun X, Sang M
Cancer medicine 2024 Feb;13(3):e6951
Cancer medicine 2024 Feb;13(3):e6951
2α, 3α, 24-Thrihydroxyurs-12-en-24-ursolic acid enhances the cytotoxic effect of cisplatin on oral cancer cells by down-regulating autophagy.
Zhang W, Lu R, Lv L, Ma C, Ding Y, Yang F, Fang Q, Wu Y, Pan R, Chen Y
Journal of cellular biochemistry 2024 Feb;125(2):e30504
Journal of cellular biochemistry 2024 Feb;125(2):e30504
Salvianolic acid A provides neuroprotective effects on cerebral ischemia-reperfusion injury in rats via PKA/CREB/c-Fos signaling pathway.
Yang R, Hu N, Liu TY, Qu Y, Liu J, Wang JH, Yang BF, Li CL
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155326
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155326
SPAG6 regulates cell proliferation and apoptosis via TGF-β/Smad signal pathway in adult B-cell acute lymphoblastic leukemia.
Zhao B, Yin J, Ding L, Luo J, Luo J, Mu J, Pan S, Du J, Zhong Y, Zhang L, Liu L
International journal of hematology 2024 Feb;119(2):119-129
International journal of hematology 2024 Feb;119(2):119-129
Coenzyme Q10 Protects Against Hyperlipidemia-Induced Osteoporosis by Improving Mitochondrial Function via Modulating miR-130b-3p/PGC-1α Pathway.
Meng M, Wang J, Wang C, Zhao J, Wang H, Zhang Y, Sun H, Liu M
Calcified tissue international 2024 Feb;114(2):182-199
Calcified tissue international 2024 Feb;114(2):182-199
IGF2BP3 loss inhibits cell progression by upregulating has_circRNA_103820, and hsa_circRNA_103820-encoded peptide inhibits cell progression by inactivating the AKT pathway in lung cancer.
Zhou J, Yao L, Su Y, Tian L
Chemical biology & drug design 2024 Feb;103(2):e14473
Chemical biology & drug design 2024 Feb;103(2):e14473
USF2 promotes autophagy and proliferation in chronic lymphocytic leukemia by inhibiting STUB1-induced NFAT5 ubiquitination.
Chen B, Zhao Y, Xu S, Jiang F, Nie Y, Tang A, Zhou Q
Annals of hematology 2024 Feb;103(2):533-544
Annals of hematology 2024 Feb;103(2):533-544
Series of Desloratadine Platinum(IV) Hybrids Displaying Potent Antimetastatic Competence by Inhibiting Epithelial-Mesenchymal Transition and Arousing Immune Response.
Zhang M, Chen Y, Liu Z, Liu M, Wang Q
Journal of medicinal chemistry 2024 Feb 8;67(3):2031-2048
Journal of medicinal chemistry 2024 Feb 8;67(3):2031-2048
Doxycycline hydrochloride inhibits the progress of malignant rhabdoid tumor of kidney by targeting MMP17 and MMP1 through PI3K-Akt signaling pathway.
Mi T, Zhang Z, Zhanghuang C, Jin L, Tan X, Liu J, Wu X, Li M, Wang J, Wang Z, Guo P, He D
European journal of pharmacology 2024 Feb 5;964:176291
European journal of pharmacology 2024 Feb 5;964:176291
Cecropin A Alleviates LPS-Induced Oxidative Stress and Apoptosis of Bovine Endometrial Epithelial Cells.
Zhao Y, Zhang Y, Sun M, Li B, Li Y, Hua S
Animals : an open access journal from MDPI 2024 Feb 29;14(5)
Animals : an open access journal from MDPI 2024 Feb 29;14(5)
Genome-wide CRISPR screen identifies ESPL1 limits the response of gastric cancer cells to apatinib.
Zhang B, Chen Y, Chen X, Ren Z, Xiang H, Mao L, Zhu G
Cancer cell international 2024 Feb 24;24(1):83
Cancer cell international 2024 Feb 24;24(1):83
Protective effects of Pt-N-C single-atom nanozymes against myocardial ischemia-reperfusion injury.
Ye T, Chen C, Wang D, Huang C, Yan Z, Chen Y, Jin X, Wang X, Ding X, Shen C
Nature communications 2024 Feb 23;15(1):1682
Nature communications 2024 Feb 23;15(1):1682
Exosomes of endothelial progenitor cells repair injured vascular endothelial cells through the Bcl2/Bax/Caspase-3 pathway.
Tan W, Li Y, Ma L, Fu X, Long Q, Yan F, Li W, Liu X, Ding H, Wang Y, Zhang W
Scientific reports 2024 Feb 23;14(1):4465
Scientific reports 2024 Feb 23;14(1):4465
Modification of BCLX pre-mRNA splicing has antitumor efficacy alone or in combination with radiotherapy in human glioblastoma cells.
Dou Z, Lei H, Su W, Zhang T, Chen X, Yu B, Zhen X, Si J, Sun C, Zhang H, Di C
Cell death & disease 2024 Feb 21;15(2):160
Cell death & disease 2024 Feb 21;15(2):160
miR-34c-5p inhibited fibroblast proliferation, differentiation and epithelial-mesenchymal transition in benign airway stenosis via MDMX/p53 pathway.
Wei J, Chen Y, Feng T, Wei Y, Yang C, Zhang C, Li W, Liu G
Functional & integrative genomics 2024 Feb 20;24(2):37
Functional & integrative genomics 2024 Feb 20;24(2):37
Xingnaojing injection alleviates cerebral ischemia/reperfusion injury through regulating endoplasmic reticulum stress in Vivo and in Vitro.
Dong X, Li C, Yao Y, Liu F, Jiang P, Gao Y
Heliyon 2024 Feb 15;10(3):e25267
Heliyon 2024 Feb 15;10(3):e25267
Oridonin-induced ferroptosis and apoptosis: a dual approach to suppress the growth of osteosarcoma cells.
Zhang F, Hao Y, Yang N, Liu M, Luo Y, Zhang Y, Zhou J, Liu H, Li J
BMC cancer 2024 Feb 12;24(1):198
BMC cancer 2024 Feb 12;24(1):198
High expression of TBRG4 in relation to unfavorable outcome and cell ferroptosis in hepatocellular carcinoma.
Tao S, Cui D, Cheng H, Liu X, Jiang Z, Chen H, Gao Y
BMC cancer 2024 Feb 12;24(1):194
BMC cancer 2024 Feb 12;24(1):194
Baicalein improves Na(2)SeO(3) induced cataract by enhancing the antioxidant capacity of juvenile Sprague Dawley Rat.
Hu N, Jin FY, Gao MM, Liu LJ, Wang JH, Yang BF, Li CL
Journal of ethnopharmacology 2024 Feb 10;320:117433
Journal of ethnopharmacology 2024 Feb 10;320:117433
β-Lapachone induces ferroptosis of colorectal cancer cells via NCOA4-mediated ferritinophagy by activating JNK pathway.
Zhao L, Miao H, Quan M, Wang S, Zhang Y, Zhou H, Zhang X, Lin Z, Piao J
Chemico-biological interactions 2024 Feb 1;389:110866
Chemico-biological interactions 2024 Feb 1;389:110866
Quercetin attenuates cadmium-induced hepatotoxicity by suppressing oxidative stress and apoptosis in rat.
Shi Y, Wang K, Ling H, Mao J, Xu B, Liu Z, Wang J
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 2024 Dec;86:127554
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 2024 Dec;86:127554
Amitraz mechanisms of cytotoxicity in a characterized SH-SY5Y cells spheroid model.
Franco-Campos F, Fernández-Franzón M, Rodríguez-Carrasco Y, Ruiz MJ
Toxicology 2024 Dec;509:153987
Toxicology 2024 Dec;509:153987
Melatonin antagonizes oxidative stress-induced apoptosis in retinal ganglion cells through activating the thioredoxin-1 pathway.
Gao S, Cheng Q, Hu Y, Fan X, Liang C, Niu C, Kang Q, Wei T
Molecular and cellular biochemistry 2024 Dec;479(12):3393-3404
Molecular and cellular biochemistry 2024 Dec;479(12):3393-3404
Geniposide alleviates heart failure with preserved ejection fraction in mice by regulating cardiac oxidative stress via MMP2/SIRT1/GSK3β pathway.
Han YL, Yan TT, Li HX, Chen SS, Zhang ZZ, Wang MY, Chen MJ, Chen YL, Yang XX, Wei LL, Duan YJ, Zhang S
Acta pharmacologica Sinica 2024 Dec;45(12):2567-2578
Acta pharmacologica Sinica 2024 Dec;45(12):2567-2578
Novel isobavachalcone derivatives induce apoptosis and necroptosis in human non-small cell lung cancer H1975 cells.
Chen J, Zhao L, Xu MF, Huang D, Sun XL, Zhang YX, Li HM, Wu CZ
Journal of enzyme inhibition and medicinal chemistry 2024 Dec;39(1):2292006
Journal of enzyme inhibition and medicinal chemistry 2024 Dec;39(1):2292006
Revealing the mechanism of Gualou-Xiebai against myocardial ischemia based on network pharmacology and energy metabolism strategies.
Jiang Q, Wen Y, Chen P, Hong X, Qian R, Liu J, Li J, Huang F, Han L
Biomedical chromatography : BMC 2024 Dec;38(12):e6007
Biomedical chromatography : BMC 2024 Dec;38(12):e6007
A cisplatin and disulphiram co-loaded inclusion complex overcomes drug resistance by inhibiting cancer cell stemness in non-small cell lung cancer.
Ye W, Lv H, Zhang Q, Zhao J, Zhao X, Zhao G, Yan C, Sun F, Zhao Z, Jia X
Journal of drug targeting 2024 Dec;32(2):159-171
Journal of drug targeting 2024 Dec;32(2):159-171
Mitochondrial HKDC1 suppresses oxidative stress and apoptosis by regulating mitochondrial function in goose fatty liver.
Xing Y, Ge J, Wang Y, Zhou X, Yuan Z, Lv M, Zhao M, Liu L, Gong D, Geng T, Xie K
International journal of biological macromolecules 2024 Dec;282(Pt 4):137222
International journal of biological macromolecules 2024 Dec;282(Pt 4):137222
Self-assembled metal-polyphenolic based multifunctional nanomedicine to improve therapy treatment of pancreatic cancer by inhibition of glutamine metabolism.
Dai Y, Li J, Wang T, Zhang X, Du P, Dong Y, Jiao Z
Colloids and surfaces. B, Biointerfaces 2024 Dec;244:114162
Colloids and surfaces. B, Biointerfaces 2024 Dec;244:114162
Critical role of apoptosis in MeCP2-mediated epithelial-mesenchymal transition of ARPE-19 cells.
Zhang Y, Wu F, Guo S, Yin R, Yuan M, Li X, Zhao X, Li X
Journal of cellular physiology 2024 Dec;239(12):e31429
Journal of cellular physiology 2024 Dec;239(12):e31429
PX-478 induces apoptosis in acute myeloid leukemia under hypoxia by inhibiting the PI3K/AKT/mTOR pathway through downregulation of GBE1.
Liu W, Dou C, Zhang C, Chen P, Zhang S, Wang R, Han Q, Zhao H, Li D
Biochemical pharmacology 2024 Dec;230(Pt 3):116620
Biochemical pharmacology 2024 Dec;230(Pt 3):116620
ITFG2 as a NEDD4-2 inhibitor: Preserving calcium homeostasis to prevent myocardial ischemic injury.
Liu F, Lv LF, Bi FF, Pan QM, Jing ZH, Cui C, Cao M, Yu T, Li J, He YJ, Xiao HW, Tian H, Wu Y, Shan HL, Zhou YH
Biochemical pharmacology 2024 Dec;230(Pt 2):116597
Biochemical pharmacology 2024 Dec;230(Pt 2):116597
Sulforaphane acts through the NFE2L2/AMPK signaling pathway to protect boar spermatozoa from cryoinjury by activating antioxidant defenses.
Zhang G, Wen F, Li Y, Sun P, Li Y, Hu Z, Wang H, Ma Y, Liang G, Chen L, Yang K, Hu J
Theriogenology 2024 Dec;230:330-340
Theriogenology 2024 Dec;230:330-340
Oleanolic acid promotes porcine oocyte maturation by activating the Nrf2/HO-1 signalling pathway.
Wang YQ, Dong YW, Qu HX, Qi JJ, Yan CX, Wei HK, Sun H, Sun BX, Liang S
Theriogenology 2024 Dec;230:203-211
Theriogenology 2024 Dec;230:203-211
JuA alleviates liver ischemia-reperfusion injury by activating AKT/NRF2/HO-1 pathways.
Fang H, Xu M, Zhang J, Qin H, Tang H, He Y, Guo W
Biochimica et biophysica acta. Molecular basis of disease 2024 Dec;1870(8):167496
Biochimica et biophysica acta. Molecular basis of disease 2024 Dec;1870(8):167496
In vitro and in vivo studies of a decanuclear Ni(II) complex as a potential anti-breast cancer agent.
Zhu H, Li H, Ji Y, Hou M, Yang Q, Liang L, Li W
Bioorganic chemistry 2024 Dec;153:107949
Bioorganic chemistry 2024 Dec;153:107949
Avenanthramide A potentiates Bim-mediated antineoplastic properties of 5-fluorouracil via targeting KDM4C/MIR17HG/GSK-3β negative feedback loop in colorectal cancer.
Fu R, Dou Z, Li N, Fan X, Amin S, Zhang J, Wang Y, Li Z, Li Z, Yang P
Acta pharmaceutica Sinica. B 2024 Dec;14(12):5321-5340
Acta pharmaceutica Sinica. B 2024 Dec;14(12):5321-5340
A combined treatment with Ursolic acid and Solasodine inhibits colorectal cancer progression through the AKT1/ERK1/2-GSK-3β-β-catenin axis.
Yang Y, Liu P, Jin Y, Zhu H, Wang M, Jiang X, Gao H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156068
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156068
Ginkgolide A enhances FoxO1 expression and reduces endoplasmic reticulum stress to mitigate osteoarthritis in mice.
Yu H, Liang J, Bao Y, Chen K, Jin Y, Li X, Chen H, Gou Y, Lu K, Lin Z
International immunopharmacology 2024 Dec 5;142(Pt B):113116
International immunopharmacology 2024 Dec 5;142(Pt B):113116
Identification of a nomogram predicting overall survival based on ADAP2-related apoptosis genes in gliomas.
Zhang C, Wang J, Niu Z, Zhang K, Wang C, Wang S, Hou S, Yu D, Lin N
International immunopharmacology 2024 Dec 5;142(Pt A):113084
International immunopharmacology 2024 Dec 5;142(Pt A):113084
Mechanism investigation of Forsythoside A against esophageal squamous cell carcinoma in vitro and in vivo.
Yang Y, Shen J, Deng P, Chen P
Cancer biology & therapy 2024 Dec 31;25(1):2380023
Cancer biology & therapy 2024 Dec 31;25(1):2380023
MiR-490-3p promotes cell apoptosis and cell-cycle arrest in osteosarcoma via the modulation of CDCA8/ATF3 by targeting NUSAP1.
Wang H, Wang H, Liu Z, Wu P, Dai R, Hong D, Nakamura T, Ren W
Translational pediatrics 2024 Dec 31;13(12):2242-2253
Translational pediatrics 2024 Dec 31;13(12):2242-2253
miR-134-3p Regulates Cell Proliferation and Apoptosis by Targeting INHBA via Inhibiting the TGF-β/PI3K/AKT Pathway in Sheep Granulosa Cells.
Huang X, Bao Y, Yang F, Li X, Wang F, Zhang C
Biology 2024 Dec 30;14(1)
Biology 2024 Dec 30;14(1)
OTULIN confers cisplatin resistance in osteosarcoma by mediating GPX4 protein homeostasis to evade the mitochondrial apoptotic pathway.
Zheng Z, Zeng Y, Bao X, Huang C, Guo F, Xu F, Luo Z
Journal of experimental & clinical cancer research : CR 2024 Dec 26;43(1):330
Journal of experimental & clinical cancer research : CR 2024 Dec 26;43(1):330
IGFALS suppresses hepatocellular carcinoma progression by stabilizing PPAR-γ.
Xu L, Xiong L, Chen Y, Chen J, Liu X, Xu Y, Shen Y, Wang S, Yu S, Xu X
International immunopharmacology 2024 Dec 25;143(Pt 2):113414
International immunopharmacology 2024 Dec 25;143(Pt 2):113414
MUL1 identified as mitochondria-linked biomarker promoting cisplatin resistance in OC cells.
Liu L, Zou C, Shen J, Huang R, Zhang F, Du Y, Luo X, Yang A, Zhang J, Guan Y, Yan X
Gene 2024 Dec 20;930:148841
Gene 2024 Dec 20;930:148841
SLC25A21 correlates with the prognosis of adult acute myeloid leukemia through inhibiting the growth of leukemia cells via downregulating CXCL8.
Liu Y, Xu Y, Hao Q, Shi L, Chen Y, Liu Y, Li M, Zhang Y, Li T, Li Y, Jiang Z, Liu Y, Wang C, Bian Z, Yang L, Wang S
Cell death & disease 2024 Dec 20;15(12):921
Cell death & disease 2024 Dec 20;15(12):921
LOC730101 improves ovarian cancer drug sensitivity by inhibiting autophagy-mediated DNA damage repair via BECN1.
Zhong Y, Shuai Y, Yang J, Zhang M, He T, Zheng L, Yang S, Peng S
Cell death & disease 2024 Dec 18;15(12):893
Cell death & disease 2024 Dec 18;15(12):893
Elaiophylin targets EIF4B to suppress the growth of esophageal squamous cell carcinoma via the PI3K/AKT signaling pathway.
Qiu H, Gao L, Shi W, Wang J, Li B, Ke S, Chen J, Gong Y, Wu Y, Zhao W, Chen Y
Cancer letters 2024 Dec 16;611:217401
Cancer letters 2024 Dec 16;611:217401
Transcription factor PRRX1-activated ANXA6 facilitates EGFR-PKCα complex formation and enhances cisplatin sensitivity in bladder cancer.
Cao J, Chen S, Wang J, Fan X, Liu S, Li X, Yang L
Life sciences 2024 Dec 15;359:123228
Life sciences 2024 Dec 15;359:123228
Matrine promotes colorectal cancer apoptosis by downregulating shank-associated RH domain interactor expression.
Zhou YC, Wang QQ, Zhou GY, Yin TF, Zhao DY, Sun XZ, Tan C, Zhou L, Yao SK
World journal of gastrointestinal oncology 2024 Dec 15;16(12):4700-4715
World journal of gastrointestinal oncology 2024 Dec 15;16(12):4700-4715
Discovery of the First BRD4 Second Bromodomain (BD2)-Selective Inhibitors.
Li J, Hu Q, Zhu R, Dong R, Shen H, Hu J, Zhang C, Zhang X, Xu T, Xiang Q, Zhang Y, Lin B, Zhao L, Wu X, Xu Y
Journal of medicinal chemistry 2024 Dec 12;67(23):21577-21616
Journal of medicinal chemistry 2024 Dec 12;67(23):21577-21616
Enhancing therapeutic efficacy in homologous recombination-proficient pancreatic cancer via the combination of PARP1-PROTAC and a BRD4 inhibitor.
Pu C, Liu Y, Lan S, Fan H, Liu L, Liu J, Guo Y
Bioorganic & medicinal chemistry 2024 Dec 1;115:117970
Bioorganic & medicinal chemistry 2024 Dec 1;115:117970
H(2)S-releasing oridonin derivatives with improved antitumor activity by inhibiting the PI3K/AKT pathway.
Li H, Ma Q, Jia Y, Wang C, Wu J, Wang S, Hua H, Lu J, Li D
Bioorganic & medicinal chemistry 2024 Dec 1;115:117968
Bioorganic & medicinal chemistry 2024 Dec 1;115:117968
Isoliquiritigenin Alleviates Diabetic Kidney Disease via Oxidative Stress and the TLR4/NF-κB/NLRP3 Inflammasome Pathway.
Wang Y, Yang J, Chang X, Xue Y, Liu G, Zhang T, Chen W, Fan W, Tian J, Ren X
Molecular nutrition & food research 2024 Aug;68(16):e2400215
Molecular nutrition & food research 2024 Aug;68(16):e2400215
Presenilin2 D439A Mutation Induces Dysfunction of Mitochondrial Fusion/Fission Dynamics and Abnormal Regulation of GTPase Activity.
Gao C, Shang J, Sun Z, Xia M, Gao D, Sun R, Li W, Wang F, Zhang J
Molecular neurobiology 2024 Aug;61(8):5047-5070
Molecular neurobiology 2024 Aug;61(8):5047-5070
SNX14 inhibits autophagy via the PI3K/AKT/mTOR signaling cascade in breast cancer cells.
Lv S, Jiang H, Yu L, Zhang Y, Sun L, Xu J
Journal of molecular histology 2024 Aug;55(4):391-401
Journal of molecular histology 2024 Aug;55(4):391-401
Long noncoding RNA ANRIL alleviates hypoxia-induced pulmonary microvascular endothelial cell damage.
Qi Y, Chen M, Zhang T, Zhao B, Jin T, Yuan D
European journal of clinical investigation 2024 Aug;54(8):e14202
European journal of clinical investigation 2024 Aug;54(8):e14202
Digitoxin inhibits ICC cell properties via the NF‑κB/ST6GAL1 signaling pathway.
Zhan Y, Wang R, Huang C, Xu X, Xiao X, Wu L, Wei J, Long T, Gao C
Oncology reports 2024 Aug;52(2)
Oncology reports 2024 Aug;52(2)
Hematoporphyrin derivative-mediated photodynamic techniques for the diagnosis and treatment of chordoma.
Li L, Wei KL, Liu MS, Wang QL, Zeng TF, Chen RZ, Xia XW, Zhang HT
Photodiagnosis and photodynamic therapy 2024 Aug;48:104231
Photodiagnosis and photodynamic therapy 2024 Aug;48:104231
Integration of serum pharmacochemistry with network pharmacology to reveal the potential mechanism of Yangqing Chenfei formula for the treatment of silicosis.
Yuanyuan HU, Xinguang L, Peng Z, Jinyan WU, Xinhua Y, Runsu H, Xiangcheng W, Fan Y, Xinrong T, Jiansheng LI
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2024 Aug;44(4):784-793
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2024 Aug;44(4):784-793
Fungal metabolite altersolanol a exhibits potent cytotoxicity against human placental trophoblasts in vitro via mitochondria-mediated apoptosis.
Gu T, Wen Y, Zhou Q, Yuan W, Guo H, Chang WL, Yang Q
Mycotoxin research 2024 Aug;40(3):419-432
Mycotoxin research 2024 Aug;40(3):419-432
SND1 Promotes Radioresistance in Cervical Cancer Cells by Targeting the DNA Damage Response.
Fu X, Duan Z, Lu X, Zhu Y, Ren Y, Zhang W, Sun X, Ge L, Yang J
Cancer biotherapy & radiopharmaceuticals 2024 Aug;39(6):425-434
Cancer biotherapy & radiopharmaceuticals 2024 Aug;39(6):425-434
MGST3 regulates BACE1 protein translation and amyloidogenesis by controlling the RGS4-mediated AKT signaling pathway.
Pu Y, Yang J, Pan Q, Li C, Wang L, Xie X, Chen X, Xiao F, Chen G
The Journal of biological chemistry 2024 Aug;300(8):107530
The Journal of biological chemistry 2024 Aug;300(8):107530
Identifying SLC2A6 as the novel protective factor in breast cancer by TP53-related genes affecting M1 macrophage infiltration.
Dai C, Man Y, Zhang L, Zhang X, Xie C, Wang S, Zhang Y, Guo Q, Zou L, Hong H, Jiang L, Shi Y
Apoptosis : an international journal on programmed cell death 2024 Aug;29(7-8):1211-1231
Apoptosis : an international journal on programmed cell death 2024 Aug;29(7-8):1211-1231
Improving Granulosa Cell Function in Premature Ovarian Failure with Umbilical Cord Mesenchymal Stromal Cell Exosome-Derived hsa_circ_0002021.
Yang G, Zhang B, Xu M, Wu M, Lin J, Luo Z, Chen Y, Hu Q, Huang G, Hu H
Tissue engineering and regenerative medicine 2024 Aug;21(6):897-914
Tissue engineering and regenerative medicine 2024 Aug;21(6):897-914
Tumor-targeted nano-assemblies for energy-blocking cocktail therapy in cancer.
Chen M, Liu Y, Li Y, Liu X
Acta biomaterialia 2024 Aug;184:368-382
Acta biomaterialia 2024 Aug;184:368-382
Ginkgolide B effectively mitigates neuropathic pain by suppressing the activation of the NLRP3 inflammasome through the induction of mitophagy in rats.
Liang JH, Yu H, Xia CP, Zheng YH, Zhang Z, Chen Y, Raza MA, Wu L, Yan H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:117006
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:117006
Lipoamide Attenuates Hypertensive Myocardial Hypertrophy Through PI3K/Akt-Mediated Nrf2 Signaling Pathway.
Cao H, Zhao L, Yuan Y, Liao C, Zeng W, Li A, Huang Q, Zhao Y, Fan Y, Jiang L, Song D, Li S, Zhang B
Journal of cardiovascular translational research 2024 Aug;17(4):910-922
Journal of cardiovascular translational research 2024 Aug;17(4):910-922
Mzb1 Attenuates Atherosclerotic Plaque Vulnerability in ApoE-/- Mice by Alleviating Apoptosis and Modulating Mitochondrial Function.
Zhu G, Li Y, Gao H, Li X, Fan H, Fan L
Journal of cardiovascular translational research 2024 Aug;17(4):782-794
Journal of cardiovascular translational research 2024 Aug;17(4):782-794
N-acetylcysteine stimulates the proliferation and differentiation in heat-stressed skeletal muscle cells.
Lu J, Zhao P, Ding X, Li H
Journal of thermal biology 2024 Aug;124:103958
Journal of thermal biology 2024 Aug;124:103958
Canadine Platinum(IV) Complexes Targeting Epithelial-Mesenchymal Transition as Antiproliferative and Antimetastatic Agents.
Chen Y, Zhang M, He Y, Li S, Feng S, Liu Z, Zhang N, Liu M, Wang Q
Journal of medicinal chemistry 2024 Aug 8;67(15):12868-12886
Journal of medicinal chemistry 2024 Aug 8;67(15):12868-12886
LINC01410 accelerates the invasion of trophoblast cells by modulating METTL3/Fas.
Yang Y, Chen M, Lan R, Gong H
Molecular biology reports 2024 Aug 8;51(1):895
Molecular biology reports 2024 Aug 8;51(1):895
Melatonin alleviates palmitic acid-induced mitochondrial dysfunction by reducing oxidative stress and enhancing autophagy in bovine endometrial epithelial cells.
Wang Y, Gong J, Heng N, Hu Y, Wang R, Wang H, He W, Zhu N, Hu Z, Hao H, Zhu H, Zhao S
Journal of animal science and biotechnology 2024 Aug 8;15(1):108
Journal of animal science and biotechnology 2024 Aug 8;15(1):108
Glycyrrhetinic acid triggers a protective autophagy by inhibiting the JAK2/STAT3 pathway in cerebral ischemia/reperfusion injury.
Liang JF, Qin XD, Huang XH, Fan ZP, Zhi YY, Xu JW, Chen F, Pan ZL, Chen YF, Zheng CB, Lu J
Neuroscience 2024 Aug 30;554:96-106
Neuroscience 2024 Aug 30;554:96-106
Bacillus subtilis alleviates excessive apoptosis of intestinal epithelial cells in intrauterine growth restriction suckling piglets via the members of Bcl-2 and caspase families.
Xie Z, Yun Y, Yu G, Zhang X, Zhang H, Wang T, Zhang L
Journal of the science of food and agriculture 2024 Aug 30;104(11):6924-6932
Journal of the science of food and agriculture 2024 Aug 30;104(11):6924-6932
Synergistic effects of plasma-activated medium in combination with Baicalin against neuronal damage.
Zhu J, Liu Q, Chen Y, Zhang J, Xu Q, Wu Z
Heliyon 2024 Aug 30;10(16):e36079
Heliyon 2024 Aug 30;10(16):e36079
BCAA mediated microbiota-liver-heart crosstalk regulates diabetic cardiomyopathy via FGF21.
Zheng H, Zhang X, Li C, Wang D, Shen Y, Lu J, Zhao L, Li X, Gao H
Microbiome 2024 Aug 24;12(1):157
Microbiome 2024 Aug 24;12(1):157
Bombinin-BO1 induces hepatocellular carcinoma cell-cycle arrest and apoptosis via the HSP90A-Cdc37-CDK1 axis.
Wang X, Tang P, Gong Y, Yao H, Liang M, Qu H, Han X, Zheng Q, Shi Z, Li D, Jiang Q
iScience 2024 Aug 16;27(8):110382
iScience 2024 Aug 16;27(8):110382
Effect of acacetin on inhibition of apoptosis in Helicobacter pylori-infected gastric epithelial cell line.
Yao QX, Li ZY, Kang HL, He X, Kang M
World journal of gastrointestinal oncology 2024 Aug 15;16(8):3624-3634
World journal of gastrointestinal oncology 2024 Aug 15;16(8):3624-3634
Fisetin Promotes Functional Recovery after Spinal Cord Injury by Inhibiting Microglia/Macrophage M1 Polarization and JAK2/STAT3 Signaling Pathway.
Ji R, Hao Z, Wang H, Su Y, Yang W, Li X, Duan L, Guan F, Ma S
Journal of agricultural and food chemistry 2024 Aug 14;72(32):17964-17976
Journal of agricultural and food chemistry 2024 Aug 14;72(32):17964-17976
Does rAj-Tspin, a novel peptide from A. japonicus, exert antihepatocellular carcinoma effects via the ITGB1/ZYX/FAK/AKT signaling pathway?
Che Y, Lu X, Wang X, Liu Z, Guan L, Li X, Du Z, Ren H, Wang J, Zhou Z, Lv L
Cancer cell international 2024 Aug 14;24(1):290
Cancer cell international 2024 Aug 14;24(1):290
FGF2 promotes the proliferation of injured granulosa cells in premature ovarian failure via Hippo-YAP signaling pathway.
Cheng F, Wang J, Wang R, Pan R, Cui Z, Wang L, Wang L, Yang X
Molecular and cellular endocrinology 2024 Aug 1;589:112248
Molecular and cellular endocrinology 2024 Aug 1;589:112248
Sodium octanoate alleviates cardiac and cerebral injury after traumatic cardiac arrest in a porcine model.
Lin Y, Chen Q, Zhang G, Xie L, Yang X, Zhong H, Xu J, Zhang M
The American journal of emergency medicine 2024 Apr;78:48-56
The American journal of emergency medicine 2024 Apr;78:48-56
Botulinum Toxin Type A Alleviates Androgenetic Alopecia by Inhibiting Apoptosis of Dermal Papilla Cells via Targeting circ_0135062/miR-506-3p/Bax Axis.
Wei W, Zhao G, Li Q, Zhang J, Wei H, Shen C, Zhao B, Ji Z, Wang L, Guo Y, Jin P
Aesthetic plastic surgery 2024 Apr;48(7):1473-1486
Aesthetic plastic surgery 2024 Apr;48(7):1473-1486
LncRNA LOXL1-AS1 promotes proliferation and invasion and inhibits apoptosis in retinoblastoma by regulating the MAPK signaling pathway.
Wu W, Zhang Y, Xu C, Yang H, Liu S, Huang G
Molecular and cellular biochemistry 2024 Apr;479(4):1011-1022
Molecular and cellular biochemistry 2024 Apr;479(4):1011-1022
IRF4 induces M1 macrophage polarization and aggravates ulcerative colitis progression by the Bcl6-dependent STAT3 pathway.
Wang J, Wu Z, Huang Y, Jin L, Xu J, Yao Z, Ouyang X, Zhou Z, Mao S, Cao J, Lai B, Shen W
Environmental toxicology 2024 Apr;39(4):2390-2404
Environmental toxicology 2024 Apr;39(4):2390-2404
Long-term Cu exposure alters CYP450s activity and induces jejunum injury and apoptosis in broilers.
Li L, Zhong G, Li Y, Li T, Huo Y, Ma F, Li Y, Zhang H, Pan J, Hu L, Liao J, Tang Z
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2024 Apr;37(2):421-432
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2024 Apr;37(2):421-432
Integrating Network Pharmacology and Experimental Validation to Reveal the Mechanism of Vine Grape Tea Polyphenols on Hyperuricemia-Induced Renal Injury in Mice.
Li X, Li B, Meng X, Yu F, Yu X, Zhao W, Wang Y, Gao H, Cheng M, Zhong L
Journal of medicinal food 2024 Apr;27(4):312-329
Journal of medicinal food 2024 Apr;27(4):312-329
TuBG1 promotes hepatocellular carcinoma via ATR/P53-apoptosis and cycling pathways.
Zhang Y, Wang ZZ, Han AQ, Yang MY, Zhu LX, Pan FM, Wang Y
Hepatobiliary & pancreatic diseases international : HBPD INT 2024 Apr;23(2):195-209
Hepatobiliary & pancreatic diseases international : HBPD INT 2024 Apr;23(2):195-209
A pyrazolopyridine as a novel AhR signaling activator with anti-breast cancer properties in vitro and in vivo.
Abduh MS, Alwassil OI, Aldaqal SM, Alfwuaires MA, Farhan M, Hanieh H
Biochemical pharmacology 2024 Apr;222:116079
Biochemical pharmacology 2024 Apr;222:116079
Tris-Functionalized Polyoxotungstovanadate-Mediated Antitumor Efficacy Involves Multiple Cell Death Pathways.
Chen L, Zhao Z, Diarimalala RO, Chen Z, Wang Y, Zhan T, Zhao Y, Ma C, Wang X, Zhao C, Xiao Z, Hu K, Wu P
Chemistry & biodiversity 2024 Apr;21(4):e202301898
Chemistry & biodiversity 2024 Apr;21(4):e202301898
Ginsenoside Rk1 induces autophagy-dependent apoptosis in hepatocellular carcinoma by AMPK/mTOR signaling pathway.
Wu H, Qu L, Bai X, Zhu C, Liu Y, Duan Z, Liu H, Fu R, Fan D
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Apr;186:114587
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2024 Apr;186:114587
Rosmarinic acid mitigates acrylamide induced neurotoxicity via suppressing endoplasmic reticulum stress and inflammation in mouse hippocampus.
Wang TB, He Y, Li RC, Yu YX, Liu Y, Qi ZQ
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155448
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155448
Regulatory mechanism of perinatal nonylphenol exposure on cardiac mitochondrial autophagy and the PINK1/Parkin signaling pathway in male offspring rats.
Yang X, Xu J, Xu Y, Wang C, Lin F, Yu J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155434
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Apr;126:155434
Diallyl disulfide synergizes with melphalan to increase apoptosis and DNA damage through elevation of reactive oxygen species in multiple myeloma cells.
Hu W, Sun J, Zhang Y, Chen T, He F, Zhao H, Tan W, Wang Z, Ouyang J, Tang Z, He J, Wang J, Li J, Zeng X, Xia J
Annals of hematology 2024 Apr;103(4):1293-1303
Annals of hematology 2024 Apr;103(4):1293-1303
Oxaliplatin-Loaded Mil-100(Fe) for Chemotherapy-Ferroptosis Combined Therapy for Gastric Cancer.
Sun B, Zheng X, Zhang X, Zhang H, Jiang Y
ACS omega 2024 Apr 9;9(14):16676-16686
ACS omega 2024 Apr 9;9(14):16676-16686
PPARγ alleviates preeclampsia development by regulating lipid metabolism and ferroptosis.
Lai W, Yu L, Deng Y
Communications biology 2024 Apr 9;7(1):429
Communications biology 2024 Apr 9;7(1):429
Anticancer properties and metabolomic profiling of Shorea roxburghii extracts toward gastrointestinal cancer cell lines.
Janthamala S, Promraksa B, Thanee M, Duenngai K, Jusakul A, Kongpetch S, Kraiklang R, Thanee K, Pinlaor P, Namwat N, Saya H, Techasen A
BMC complementary medicine and therapies 2024 Apr 30;24(1):178
BMC complementary medicine and therapies 2024 Apr 30;24(1):178
Baicalin reduces inflammation to inhibit lung cancer via targeting SOCS1/NF-κB/STAT3 axis.
Guo L, Yue M, Ma C, Wang Y, Hou J, Li H
Heliyon 2024 Apr 30;10(8):e29361
Heliyon 2024 Apr 30;10(8):e29361
The mitochondria-targeted Kaempferol nanoparticle ameliorates severe acute pancreatitis.
Wen E, Cao Y, He S, Zhang Y, You L, Wang T, Wang Z, He J, Feng Y
Journal of nanobiotechnology 2024 Apr 3;22(1):148
Journal of nanobiotechnology 2024 Apr 3;22(1):148
HIST3H2A promotes the progression of prostate cancer through inhibiting cell necroptosis.
Yang L, Ruan Y, Xu H
BMC cancer 2024 Apr 29;24(1):544
BMC cancer 2024 Apr 29;24(1):544
Targeting IDH1-Mutated Oligodendroglioma with Acid Ceramidase Inhibitors.
Muley H, Dowdy T, Zaibaq F, Karadimov G, Li A, Song H, Zhang M, Zhang W, Wong Z, Zhang L, Lita A, Larion M
bioRxiv : the preprint server for biology 2024 Apr 29;
bioRxiv : the preprint server for biology 2024 Apr 29;
Network pharmacology and experimental validation of effects of total saponins extracted from Abrus cantoniensis Hance on acetaminophen-induced liver injury.
He J, Chen L, Wang P, Cen B, Li J, Wei Y, Yao X, Xu Z
Journal of ethnopharmacology 2024 Apr 24;324:117740
Journal of ethnopharmacology 2024 Apr 24;324:117740
Tumor Supplying Artery Injection of Liposome@Sunitinib Could Effectively Inhibit the Progression of Kidney Tumor.
Fu Q, Li G, Wang L, Yin C, Yi B, Huang Y, Su Q, Zhang Z, Zhu J
ACS applied materials & interfaces 2024 Apr 24;16(16):20202-20211
ACS applied materials & interfaces 2024 Apr 24;16(16):20202-20211
Granulysin-mediated reduction of PDZRN3 induces Cx43 gap junctions activity exacerbating skin damage in trichloroethylene hypersensitivity syndrome.
Jiao B, Zhang H, Jiang H, Liu S, Wang Y, Chen Y, Duan H, Niu Y, Shen M, Wang H, Dai Y
Ecotoxicology and environmental safety 2024 Apr 1;274:116174
Ecotoxicology and environmental safety 2024 Apr 1;274:116174
Construction and validation of a hypoxia-related gene signature to predict the prognosis of breast cancer.
Qiu C, Wang W, Xu S, Li Y, Zhu J, Zhang Y, Lei C, Li W, Li H, Li X
BMC cancer 2024 Apr 1;24(1):402
BMC cancer 2024 Apr 1;24(1):402
CircGPC3 promotes hepatocellular carcinoma progression and metastasis by sponging miR-578 and regulating RAB7A/PSME3 expression.
Ju L, Luo Y, Cui X, Zhang H, Chen L, Yao M
Scientific reports 2024 Apr 1;14(1):7632
Scientific reports 2024 Apr 1;14(1):7632
Erianin Exerts Antineoplastic Effects on Esophageal Squamous Cell Carcinoma Cells by Activating the cGMP-PKG Signaling Pathway.
Deng X, Wu Q, Li D, Liu Y
Nutrition and cancer 2023;75(6):1473-1484
Nutrition and cancer 2023;75(6):1473-1484
Sulforaphane Suppresses MCF-7 Breast Cancer Cells Growth via miR-19/PTEN Axis to Antagonize the Effect of Butyl Benzyl Phthalate.
Cao W, Lu X, Zhong C, Wu J
Nutrition and cancer 2023;75(3):980-991
Nutrition and cancer 2023;75(3):980-991
Diallyl Trisulfide Suppresses the Renal Cancer Stem-like Cell Properties via Nanog.
Zhang T, Cao W, Sun H, Yu D, Zhong C
Nutrition and cancer 2023;75(3):971-979
Nutrition and cancer 2023;75(3):971-979
Semisynthesis and in Vitro Anti-cancer Effect of New Magnolol Derivatives on the Cell Proliferation, Apoptosis, Migration, and Invasion of Human Hepatocellular Carcinoma SMMC-7721 Cells.
He NN, Wang JA, Huang D, Sun XL, Ding F, Zhao L, Zhang YX, Li HM, Wu CZ
Chemical & pharmaceutical bulletin 2023;71(11):798-803
Chemical & pharmaceutical bulletin 2023;71(11):798-803
Overexpressing six-transmembrane protein of prostate 2 (STAMP2) alleviates sepsis-induced acute lung injury probably by hindering M1 macrophage polarization via the NF-κB pathway.
Ji L, Shi X, Wang G, Wu H, Hu Z
Folia histochemica et cytobiologica 2023;61(1):34-46
Folia histochemica et cytobiologica 2023;61(1):34-46
Phenolic profile, antioxidation and anti-proliferation activity of phenolic-rich extracts from Sanghuangporusvaninii.
Gao H, Yin C, Li C, Li Y, Shi D, Fan X, Yao F, Wu W, Li J
Current research in food science 2023;6:100519
Current research in food science 2023;6:100519
Baicalin Reduces Immune Cell Infiltration by Inhibiting Inflammation and Protecting Tight Junctions in Ischemic Stroke Injury.
Hao Z, Zhang Z, Zhao Y, Wang D
The American journal of Chinese medicine 2023;51(2):355-372
The American journal of Chinese medicine 2023;51(2):355-372
The SARS-CoV-2 spike glycoprotein interacts with MAO-B and impairs mitochondrial energetics.
Pileggi CA, Parmar G, Elkhatib H, Stewart CM, Alecu I, Côté M, Bennett SAL, Sandhu JK, Cuperlovic-Culf M, Harper ME
Current research in neurobiology 2023;5:100112
Current research in neurobiology 2023;5:100112
Andrographolide alleviates paraquat-induced acute lung injury by activating the Nrf2/HO-1 pathway.
Zhang D, Shen F, Ma S, Nan S, Ma Y, Ren L, Li H, Yu Q
Iranian journal of basic medical sciences 2023;26(6):653-661
Iranian journal of basic medical sciences 2023;26(6):653-661
Penehyclidine Hydrochloride Protects Rat Cardiomyocytes from Ischemia- Reperfusion Injury by Platelet-derived Growth Factor-B.
Lu Y, Zi C, Zhang L, Cui B, Li L, Ma J
Combinatorial chemistry & high throughput screening 2023;26(6):1204-1213
Combinatorial chemistry & high throughput screening 2023;26(6):1204-1213
Lycium barbarum Polysaccharides Regulating miR-181/Bcl-2 Decreased Autophagy of Retinal Pigment Epithelium with Oxidative Stress.
Yang YJ, Wang Y, Deng Y, Liu XQ, Lu J, Peng J, Li J, Zhou YS, Zhu HA, Li B, Qin YH, Peng QH
Oxidative medicine and cellular longevity 2023;2023:9554457
Oxidative medicine and cellular longevity 2023;2023:9554457
Liraglutide Attenuates Hepatic Oxidative Stress, Inflammation, and Apoptosis in Streptozotocin-Induced Diabetic Mice by Modulating the Wnt/β-Catenin Signaling Pathway.
Yu J, Zhao Y, Xu L, Li W, Zhang H, Ping F, Li Y
Mediators of inflammation 2023;2023:8974960
Mediators of inflammation 2023;2023:8974960
Study on Neuroprotective Mechanism of Houshiheisan in Ischemic Stroke Based on Transcriptomics and Experimental Verification.
Cheng H, Zhang Y, Guo X, Wang X, Wang H, Zhao H, Wang L, Zou H, Zhang Q
Evidence-based complementary and alternative medicine : eCAM 2023;2023:8673136
Evidence-based complementary and alternative medicine : eCAM 2023;2023:8673136
A Water-Soluble Hydrogen Sulfide Donor Suppresses the Growth of Hepatocellular Carcinoma via Inhibiting the AKT/GSK-3β/β-Catenin and TGF-β/Smad2/3 Signaling Pathways.
Duan SF, Zhang MM, Dong Q, Yang B, Liu W, Zhang X, Yu HL, Zhang SH, Khan NH, Wu DD, Zhang XJ, Cen J
Journal of oncology 2023;2023:8456852
Journal of oncology 2023;2023:8456852
RING Finger Protein 10 Regulates AP-1/Meox2 to Mediate Pirarubicin-Induced Cardiomyocyte Apoptosis.
Shi H, Duan L, Lan Y, He Q, Pu P, Tang H
Oxidative medicine and cellular longevity 2023;2023:7872193
Oxidative medicine and cellular longevity 2023;2023:7872193
P7C3-A20 Attenuates Microglial Inflammation and Brain Injury after ICH through Activating the NAD(+)/Sirt3 Pathway.
Wu Y, Hu Q, Wu X, Cai YN, Zhang YZ, Wu YX, Zhu G, Luo JN, Cheng HB, Yu JG, Wang XL, Gao L, Gao GD
Oxidative medicine and cellular longevity 2023;2023:7857760
Oxidative medicine and cellular longevity 2023;2023:7857760
Circular RNA_HIPK3-Targeting miR-93-5p Regulates KLF9 Expression Level to Control Acute Kidney Injury.
Zhengbiao Z, Liang C, Zhi Z, Youmin P
Computational and mathematical methods in medicine 2023;2023:1318817
Computational and mathematical methods in medicine 2023;2023:1318817
Antioxioxidant and antiapoptotic effects of Thymosin β4 in Aβ-induced SH-SY5Y cells via the 5-HTR1A/ERK axis.
Zhang GH, Chin KL, Yan SY, Pare R
PloS one 2023;18(10):e0287817
PloS one 2023;18(10):e0287817
Thalidomide Alleviates Apoptosis, Oxidative Damage and Inflammation Induced by Pemphigus Vulgaris IgG in HaCat Cells and Neonatal Mice Through MyD88.
Luan C, Lu Z, Chen J, Chen M, Zhao R, Li X
Drug design, development and therapy 2023;17:2821-2839
Drug design, development and therapy 2023;17:2821-2839
An Integrative Pharmacology-Based Strategy to Uncover the Mechanism of Zuogui Jiangtang Shuxin Formula in Diabetic Cardiomyopathy.
Huang Y, Zhang Y, Wu Y, Xiang Q, Yu R
Drug design, development and therapy 2023;17:237-260
Drug design, development and therapy 2023;17:237-260
Mifepristone inhibits hepatoma growth by enhancing the GR-HSP60-survivin interaction to facilitate survivin degradation.
Huang YH, Lin KH, Lai MW, Yeh CT
Journal of Cancer 2023;14(16):3066-3077
Journal of Cancer 2023;14(16):3066-3077
Zhoushi Qiling decoction inhibits proliferation of human prostate cancer cells through IL6/STAT3 pathway.
Cao H, Feng Y, Sun P, Chen L, Wang D, Gao R
Journal of Cancer 2023;14(12):2246-2254
Journal of Cancer 2023;14(12):2246-2254
Myricetin suppresses TGF-β-induced epithelial-to-mesenchymal transition in ovarian cancer.
Yang HW, Lan Y, Li A, Wu H, Song ZW, Wan AL, Wang Y, Li SB, Ji S, Wang ZC, Wu XY, Lan T
Frontiers in pharmacology 2023;14:1288883
Frontiers in pharmacology 2023;14:1288883
Blockage of S100A8/A9 ameliorates septic nephropathy in mice.
Shi W, Wan TT, Li HH, Guo SB
Frontiers in pharmacology 2023;14:1172356
Frontiers in pharmacology 2023;14:1172356
Pterostilbene attenuates microglial inflammation and brain injury after intracerebral hemorrhage in an OPA1-dependent manner.
Wu Y, Hu Q, Wang X, Cheng H, Yu J, Li Y, Luo J, Zhang Q, Wu J, Zhang G
Frontiers in immunology 2023;14:1172334
Frontiers in immunology 2023;14:1172334
Reactivation of mutant p53 in esophageal squamous cell carcinoma by isothiocyanate inhibits tumor growth.
Guan L, Yang Y, Lu Y, Chen Y, Luo X, Xin D, Meng X, Shan Z, Jiang G, Wang F
Frontiers in pharmacology 2023;14:1141420
Frontiers in pharmacology 2023;14:1141420
Adjuvant therapy with Huatan Sanjie Granules improves the prognosis of patients with primary liver cancer: a cohort study and the investigation of its mechanism of action based on network pharmacology.
Yuan J, Abdurahman A, Cui N, Hao T, Zou J, Liu L, Wu Y
Frontiers in pharmacology 2023;14:1091177
Frontiers in pharmacology 2023;14:1091177
HSP105 suppresses the progression of cutaneous squamous cell carcinoma by activating the P53 signaling pathway.
Jia M, Zhou KY, Deng LJ, Fang S
American journal of cancer research 2023;13(7):3013-3026
American journal of cancer research 2023;13(7):3013-3026
Histone H3K27 methyltransferase EZH2 regulates apoptotic and inflammatory responses in sepsis-induced AKI.
Li B, Xia Y, Mei S, Ye Z, Song B, Yan X, Lin F, Rao T, Yu W, Mei C, Lv J, Wu M, Mao Z, Zhou X, Cheng F
Theranostics 2023;13(6):1860-1875
Theranostics 2023;13(6):1860-1875
Ly6D facilitates chemoresistance in laryngeal squamous cell carcinoma through miR-509/β-catenin signaling pathway.
Wang J, Sheng N, Li Y, Fan Y, Nan X, Fu R
American journal of cancer research 2023;13(5):2155-2171
American journal of cancer research 2023;13(5):2155-2171
ZY-444 inhibits the growth and metastasis of prostate cancer by targeting TNFAIP3 through TNF signaling pathway.
Han MT, Pei H, Sun QQ, Wang CL, Li P, Xie YY, Cao LJ, Zhang XX, Sun ZL
American journal of cancer research 2023;13(4):1533-1546
American journal of cancer research 2023;13(4):1533-1546
Fucose ameliorates the proinflammatory property of Fusobacterium nucleatum in colitis via altering its metabolism.
Duan C, Hou L, Deng X, Wu J, Qian W, Han C, Hou X
Frontiers in cellular and infection microbiology 2023;13:1190602
Frontiers in cellular and infection microbiology 2023;13:1190602
RNA N6-methyladenosine reader IGF2BP3 promotes acute myeloid leukemia progression by controlling stabilization of EPOR mRNA.
Fan J, Zhuang M, Fan W, Hou M
PeerJ 2023;11:e15706
PeerJ 2023;11:e15706
Combined effects of EMP and RF field on emotional behavior in mice.
Qin T, Liu L, Wang X, Guo L, Lin J, Du J, Xue Y, Lai P, Jing Y, Ding G
Frontiers in public health 2023;11:1087161
Frontiers in public health 2023;11:1087161
Shiga toxin 2 A-subunit induces mitochondrial damage, mitophagy and apoptosis via the interaction of Tom20 in Caco-2 cells.
Tang J, Lu X, Zhang T, Feng Y, Xu Q, Li J, Lan Y, Luo H, Zeng L, Xiang Y, Zhang Y, Li Q, Mao X, Tang B, Zeng D
Heliyon 2023 Sep;9(9):e20012
Heliyon 2023 Sep;9(9):e20012
Itraconazole inhibits proliferation, induces apoptosis, and reduces angiogenesis of hemangioma endothelial cells by downregulating the hedgehog signaling pathway.
Dong J, Cui J, Shi X, Wang T, Liu S
Heliyon 2023 Sep;9(9):e19244
Heliyon 2023 Sep;9(9):e19244
Over-expression of miR-3584-5p Represses Nav1.8 Channel Aggravating Neuropathic Pain caused by Chronic Constriction Injury.
Yang R, Wang QQ, Feng Y, Li XH, Li GX, She FL, Zhu XJ, Li CL
Molecular neurobiology 2023 Sep;60(9):5237-5255
Molecular neurobiology 2023 Sep;60(9):5237-5255
Biomarkers based on multiplatform comprehensive analysis: A systematic analysis of Geng-Nian-Shu in perimenopausal syndrome.
Lv X, Xu Q, Zhang Z, Wang J, Wan M, Zhang X, Wu B, Yan T, Jia Y
Journal of separation science 2023 Sep;46(17):e2300011
Journal of separation science 2023 Sep;46(17):e2300011
Long noncoding RNA LINC00173 induces radioresistance in nasopharyngeal carcinoma via inhibiting CHK2/P53 pathway.
Miao J, Chen B, Xiao Y, Huang R, Xiao X, Lu S, Zhang L, Wang X, Ouyang Y, Chen X, Chen Q, Xiang Y, Guo X, Deng X, Wang L, Mai H, Zhao C
Cancer gene therapy 2023 Sep;30(9):1249-1259
Cancer gene therapy 2023 Sep;30(9):1249-1259
MicroRNA-139-5p suppresses non-small cell lung cancer progression by targeting ATAD2.
Sun T, Liu Z
Pathology, research and practice 2023 Sep;249:154719
Pathology, research and practice 2023 Sep;249:154719
Alleviative Effect of Threonine on Cadmium-Induced Liver Injury in Mice.
Fang Z, Li Y, Wang J, Wang X, Huang L, Sun L, Deng Q
Biological trace element research 2023 Sep;201(9):4437-4446
Biological trace element research 2023 Sep;201(9):4437-4446
Degradation of histone deacetylase 6 alleviates ROS-mediated apoptosis in renal ischemia-reperfusion injury.
Xia K, Qiu T, Jian Y, Liu H, Chen H, Liu X, Chen Z, Wang L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115128
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Sep;165:115128
Artesunate alleviates intestinal ischemia/reperfusion induced acute lung injury via up-regulating AKT and HO-1 signal pathway in mice.
Ji T, Chen M, Liu Y, Jiang H, Li N, He X
International immunopharmacology 2023 Sep;122:110571
International immunopharmacology 2023 Sep;122:110571
Calycosin inhibits triple-negative breast cancer progression through down-regulation of the novel estrogen receptor-α splice variant ER-α30-mediated PI3K/AKT signaling pathway.
Li Y, Hu S, Chen Y, Zhang X, Gao H, Tian J, Chen J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Sep;118:154924
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Sep;118:154924
Extracellular vesicles produced by avian pathogenic Escherichia coli (APEC) activate macrophage proinflammatory response and neutrophil extracellular trap (NET) formation through TLR4 signaling.
Wang Z, Zhu D, Zhang Y, Xia F, Zhu J, Dai J, Zhuge X
Microbial cell factories 2023 Sep 9;22(1):177
Microbial cell factories 2023 Sep 9;22(1):177
Generation of a humanized mesonephros in pigs from induced pluripotent stem cells via embryo complementation.
Wang J, Xie W, Li N, Li W, Zhang Z, Fan N, Ouyang Z, Zhao Y, Lai C, Li H, Chen M, Quan L, Li Y, Jiang Y, Jia W, Fu L, Mazid MA, Zhu Y, Maxwell PH, Pan G, Esteban MA, Dai Z, Lai L
Cell stem cell 2023 Sep 7;30(9):1235-1245.e6
Cell stem cell 2023 Sep 7;30(9):1235-1245.e6
CBX3 promotes clear cell renal carcinoma through PI3K/AKT activation and aberrant immunity.
Chen J, Lin Y, Zheng S, Chen Q, Tang S, Zhong X
Journal of translational medicine 2023 Sep 6;21(1):600
Journal of translational medicine 2023 Sep 6;21(1):600
β-Sitosterol Suppresses Lipopolysaccharide-Induced Inflammation and Lipogenesis Disorder in Bovine Mammary Epithelial Cells.
Fan Y, Shen J, Liu X, Cui J, Liu J, Peng D, Jin Y
International journal of molecular sciences 2023 Sep 27;24(19)
International journal of molecular sciences 2023 Sep 27;24(19)
Intercellular adhesion molecule 2 as a novel prospective tumor suppressor induced by ERG promotes ubiquitination-mediated radixin degradation to inhibit gastric cancer tumorigenicity and metastasis.
Tang X, Huang J, Jiang Y, Qiu J, Li T, Li W, Chen Z, Huang Z, Yu X, Yang T, Ji X, Tan R, Lv L, Yang Z, Chen H
Journal of translational medicine 2023 Sep 27;21(1):670
Journal of translational medicine 2023 Sep 27;21(1):670
Depletion of G9A attenuates imiquimod-induced psoriatic dermatitis via targeting EDAR-NF-κB signaling in keratinocyte.
Fang Z, Wang Y, Huang B, Chen X, Jiang R, Yin M
Cell death & disease 2023 Sep 22;14(9):627
Cell death & disease 2023 Sep 22;14(9):627
[A Novel Chinese Medicine Formula Inhibits Non-small Cell Lung Cancer by Triggering Oxidative Stress Dependent on Pentose Phosphate Pathway].
Cheng C, Wu W, Yu J, Yuan D, Wang Y, Li L
Zhongguo fei ai za zhi = Chinese journal of lung cancer 2023 Sep 20;26(9):639-649
Zhongguo fei ai za zhi = Chinese journal of lung cancer 2023 Sep 20;26(9):639-649
FGF2 Rescued Cisplatin-Injured Granulosa Cells through the NRF2-Autophagy Pathway.
Wang L, Cheng F, Pan R, Cui Z, She J, Zhang Y, Yang X
International journal of molecular sciences 2023 Sep 18;24(18)
International journal of molecular sciences 2023 Sep 18;24(18)
Umbilical cord mesenchymal stem cells relieve osteoarthritis in rats through immunoregulation and inhibition of chondrocyte apoptosis.
Pan X, Li X, Zhang L, Wu F, Zhang Q, Xu S, Shen C, Liang J, Pan R
Scientific reports 2023 Sep 11;13(1):14975
Scientific reports 2023 Sep 11;13(1):14975
Obatoclax Rescues FUS-ALS Phenotypes in iPSC-Derived Neurons by Inducing Autophagy.
Castillo Bautista CM, Eismann K, Gentzel M, Pelucchi S, Mertens J, Walters HE, Yun MH, Sterneckert J
Cells 2023 Sep 11;12(18)
Cells 2023 Sep 11;12(18)
Long non-coding RNA PFI inhibits apoptosis of alveolar epithelial cells to alleviate lung injury via miR-328-3p/Creb1 axis.
Li Z, Jin T, Yang R, Guo J, Niu Z, Gao H, Song X, Zhang Q, Ning Z, Ren L, Wang Y, Fan X, Liang H, Li T, He W
Experimental cell research 2023 Sep 1;430(1):113685
Experimental cell research 2023 Sep 1;430(1):113685
Gambogenic acid induces cell death in human osteosarcoma through altering iron metabolism, disturbing the redox balance, and activating the P53 signaling pathway.
Liu Z, Wang X, Li J, Yang X, Huang J, Ji C, Li X, Li L, Zhou J, Hu Y
Chemico-biological interactions 2023 Sep 1;382:110602
Chemico-biological interactions 2023 Sep 1;382:110602
LncRNA AOC4P impacts the differentiation of macrophages and T-lymphocyte by regulating the NF-κB pathways of KGN cells: Potential pathogenesis of polycystic ovary syndrome.
Yang Z, Wu S, He S, Han L, Zhou M, Yang J, Chen J, Wu G
American journal of reproductive immunology (New York, N.Y. : 1989) 2023 Oct;90(4):e13776
American journal of reproductive immunology (New York, N.Y. : 1989) 2023 Oct;90(4):e13776
Effect of eIF2α in Neuronal Injury Induced by High Glucose and the Protective Mechanism of Resveratrol.
Zhang L, Zhi K, Su Y, Peng W, Meng X
Molecular neurobiology 2023 Oct;60(10):6043-6059
Molecular neurobiology 2023 Oct;60(10):6043-6059
Bavachinin Ameliorates Rheumatoid Arthritis Inflammation via PPARG/PI3K/AKT Signaling Pathway.
Deng H, Jiang J, Shu J, Huang M, Zhang QL, Wu LJ, Sun WK
Inflammation 2023 Oct;46(5):1981-1996
Inflammation 2023 Oct;46(5):1981-1996
Comprehensive analysis of clinical prognostic features and tumor microenvironment landscape of CD11b(+)CD64(+) patients with acute myeloid leukemia.
Wang Q, Zhang N, Liu L, Ma L, Tan Y, Liu X, Wu J, Chen G, Li X, Liang Y, Zhou F
Cellular oncology (Dordrecht, Netherlands) 2023 Oct;46(5):1253-1268
Cellular oncology (Dordrecht, Netherlands) 2023 Oct;46(5):1253-1268
Electroacupuncture inhibits hippocampal neuronal apoptosis and improves cognitive dysfunction in mice with vascular dementia via the JNK signaling pathway.
Liu Y, Yan Z, Ren Y, Wang W, Ke Y, Wang Y, Qi R
Acupuncture in medicine : journal of the British Medical Acupuncture Society 2023 Oct;41(5):284-296
Acupuncture in medicine : journal of the British Medical Acupuncture Society 2023 Oct;41(5):284-296
HBV precore G1896A mutation promotes growth of hepatocellular carcinoma cells by activating ERK/MAPK pathway.
Zhao B, Qiao H, Zhao Y, Gao Z, Wang W, Cui Y, Li J, Guo Z, Chuai X, Chiu S
Virologica Sinica 2023 Oct;38(5):680-689
Virologica Sinica 2023 Oct;38(5):680-689
BCKDHA contributes to melanoma progression by promoting the expressions of lipogenic enzymes FASN and ACLY.
Tian Y, Ma J, Wang M, Yi X, Guo S, Wang H, Zhang H, Wang H, Yang Y, Zhang B, Du J, Shi Q, Gao T, Li C, Guo W
Experimental dermatology 2023 Oct;32(10):1633-1643
Experimental dermatology 2023 Oct;32(10):1633-1643
The effect of small molecule inhibitor NSC348884 on nucleophosmin 1-mutated acute myeloid leukemia cells.
Zhu JF, Han LL, Ma Y, Wang YX, Zhang F
European review for medical and pharmacological sciences 2023 Oct;27(19):9145-9151
European review for medical and pharmacological sciences 2023 Oct;27(19):9145-9151
Depleting ANTXR1 suppresses glioma growth via deactivating PI3K/AKT pathway.
Zhou C, Liang A, Zhang J, Leng J, Xi B, Zhou B, Yang Y, Zhu R, Zhong L, Jiang X, Wan D
Cell cycle (Georgetown, Tex.) 2023 Oct;22(19):2097-2112
Cell cycle (Georgetown, Tex.) 2023 Oct;22(19):2097-2112
Acquired resistance to venetoclax plus azacitidine in acute myeloid leukemia: In vitro models and mechanisms.
Carter JL, Su Y, Qiao X, Zhao J, Wang G, Howard M, Edwards H, Bao X, Li J, Hüttemann M, Yang J, Taub JW, Ge Y
Biochemical pharmacology 2023 Oct;216:115759
Biochemical pharmacology 2023 Oct;216:115759
Targeting DHODH reveals therapeutic opportunities in ATRA-resistant acute promyelocytic leukemia.
Yang T, Shi X, Li S, Zhao Z, Wang J, Yu P, Li H, Wang R, Chen Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct;166:115314
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct;166:115314
Anti-rheumatoid arthritis effects of total saponins from Rhizoma Panacis Majoris on adjuvant-induced arthritis in rats and rheumatoid arthritis fibroblast-like synoviocytes.
Ren M, Ma K, Pang X, Liu Y, Song Z, Zhou R, Tang Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:155021
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:155021
Ganoderma lucidum polysaccharide peptide (GLPP) attenuates rheumatic arthritis in rats through inactivating NF-κB and MAPK signaling pathways.
Meng M, Wang L, Yao Y, Lin D, Wang C, Yao J, Sun H, Liu M
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:155010
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:155010
MiR-132-3p activation aggravates renal ischemia-reperfusion injury by targeting Sirt1/PGC1alpha axis.
Li C, Han S, Zhu J, Cheng F
Cellular signalling 2023 Oct;110:110801
Cellular signalling 2023 Oct;110:110801
CT2-3 induces cell cycle arrest and apoptosis in rheumatoid arthritis fibroblast-like synoviocytes through regulating PI3K/AKT pathway.
Chen J, Lin X, Liu K, He J, Li X, Zhang C, Deng Y, Luo L, Tao C, Wang Q
European journal of pharmacology 2023 Oct 5;956:175871
European journal of pharmacology 2023 Oct 5;956:175871
Zigui-Yichong-Fang protects against cyclophosphamide-induced premature ovarian insufficiency via the SIRT1/Foxo3a pathway.
Xiu Z, Tang S, Kong P, Yan M, Tong X, Liu X, Liang X, Li R, Duan Y
Journal of ethnopharmacology 2023 Oct 5;314:116608
Journal of ethnopharmacology 2023 Oct 5;314:116608
A modified Fangji Huangqi decoction ameliorates pulmonary artery hypertension via phosphatidylinositide 3-kinases/protein kinase B-mediated regulation of proliferation and apoptosis of smooth muscle cells in vitro and in vivo.
Xue Z, Zhou M, Liu Y, Qin H, Li Y, Zhu Y, Yang J
Journal of ethnopharmacology 2023 Oct 5;314:116544
Journal of ethnopharmacology 2023 Oct 5;314:116544
Decreased HAT1 expression in granulosa cells disturbs oocyte meiosis during mouse ovarian aging.
Guo B, Zhang S, Wang S, Zhang H, Fang J, Kang N, Zhen X, Zhang Y, Zhou J, Yan G, Sun H, Ding L, Liu C
Reproductive biology and endocrinology : RB&E 2023 Oct 31;21(1):103
Reproductive biology and endocrinology : RB&E 2023 Oct 31;21(1):103
Coumarins from Jinhua Finger Citron: Separation by Liquid-Liquid Chromatography and Potential Antitumor Activity.
Wang C, Huang J, Zhou Z, Xu P, Shi J, Yang Y, Tong S, Hu H
Molecules (Basel, Switzerland) 2023 Oct 3;28(19)
Molecules (Basel, Switzerland) 2023 Oct 3;28(19)
N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity.
Varland S, Silva RD, Kjosås I, Faustino A, Bogaert A, Billmann M, Boukhatmi H, Kellen B, Costanzo M, Drazic A, Osberg C, Chan K, Zhang X, Tong AHY, Andreazza S, Lee JJ, Nedyalkova L, Ušaj M, Whitworth AJ, Andrews BJ, Moffat J, Myers CL, Gevaert K, Boone C, Martinho RG, Arnesen T
Nature communications 2023 Oct 27;14(1):6774
Nature communications 2023 Oct 27;14(1):6774
Acteoside protects podocyte against apoptosis through regulating AKT/GSK-3β signaling pathway in db/db mice.
Li X, Liu Z, He Z, Wang X, Li R, Wang J, Ma G, Zhang P, Ma C
BMC endocrine disorders 2023 Oct 23;23(1):230
BMC endocrine disorders 2023 Oct 23;23(1):230
ALKBH5-mediated m(6)A demethylation of HS3ST3B1-IT1 prevents osteoarthritis progression.
Tang Y, Liu Y, Zhu X, Chen Y, Jiang X, Ding S, Zheng Q, Zhang M, Yang J, Ma Y, Xing M, Zhang Z, Ding H, Jin Y, Ma C
iScience 2023 Oct 20;26(10):107838
iScience 2023 Oct 20;26(10):107838
The Wnt/β-catenin signaling pathway inhibits osteoporosis by regulating the expression of TERT: an in vivo and in vitro study.
Cai Y, Sun H, Song X, Zhao J, Xu D, Liu M
Aging 2023 Oct 19;15(20):11471-11488
Aging 2023 Oct 19;15(20):11471-11488
Dendrobium officinale polysaccharide Converts M2 into M1 Subtype Macrophage Polarization via the STAT6/PPAR-r and JAGGED1/NOTCH1 Signaling Pathways to Inhibit Gastric Cancer.
Zhao Y, Lu X, Huang H, Yao Y, Liu H, Sun Y
Molecules (Basel, Switzerland) 2023 Oct 12;28(20)
Molecules (Basel, Switzerland) 2023 Oct 12;28(20)
Matrix stiffness induces Drp1-mediated mitochondrial fission through Piezo1 mechanotransduction in human intervertebral disc degeneration.
Ke W, Wang B, Liao Z, Song Y, Li G, Ma L, Wang K, Li S, Hua W, Yang C
Journal of translational medicine 2023 Oct 10;21(1):711
Journal of translational medicine 2023 Oct 10;21(1):711
Metformin combined with glucose starvation synergistically suppress triple-negative breast cancer by enhanced unfolded protein response.
Li Y, Zhang Q, Yang J, He W, Jiang Y, Chen Y, Wang Y
Biochemical and biophysical research communications 2023 Oct 1;675:146-154
Biochemical and biophysical research communications 2023 Oct 1;675:146-154
Oral administration of sophoricoside (SOP) inhibits neuronal damage and neuroinflammation to curb neurodegeneration in Parkinson's disease.
Wang H, He D, Li Z, Gao X, Yang S, Cui M, Ye B, Huang B, Fu S, Liu D
Chemico-biological interactions 2023 Oct 1;384:110726
Chemico-biological interactions 2023 Oct 1;384:110726
Dapagliflozin suppress endoplasmic reticulum stress mediated apoptosis of chondrocytes by activating Sirt1.
Liu Z, Huang J, Wang X, Deng S, Zhou J, Gong Z, Li X, Wang Y, Yang J, Hu Y
Chemico-biological interactions 2023 Oct 1;384:110724
Chemico-biological interactions 2023 Oct 1;384:110724
Chronic exposure to low-dose deltamethrin can lead to colon tissue injury through PRDX1 inactivation-induced mitochondrial oxidative stress injury and gut microbial dysbiosis.
Ma R, Sun T, Wang X, Ren K, Min T, Xie X, Wang D, Li K, Zhang Y, Zhu K, Mo C, Dang C, Yang Y, Zhang H
Ecotoxicology and environmental safety 2023 Oct 1;264:115475
Ecotoxicology and environmental safety 2023 Oct 1;264:115475
FUT8-Mediated Core Fucosylation Promotes the Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension.
Zhang W, Lin W, Zeng X, Zhang M, Chen Q, Tang Y, Sun J, Liang B, Zha L, Yu Z
Aging and disease 2023 Oct 1;14(5):1927-1944
Aging and disease 2023 Oct 1;14(5):1927-1944
The Extract of Pinellia Ternata-Induced Apoptosis of Leukemia Cells by Regulating the Expression of Bax, Bcl-2 and Caspase-3 Protein Expression in Mice.
Li ZF, Feng JK, Zhao XC, Liu W, Gu SA, Li R, Lu YL, Mao RJ, Xia LL, Dong LL, Zhang LW, Ruan JY, Liu J, Li GF, Li T, Sun R, Qiu SL, Zheng ZZ, Dong T
Transplantation proceedings 2023 Nov;55(9):2232-2240
Transplantation proceedings 2023 Nov;55(9):2232-2240
Knockdown of LIMD2 inhibits the progression of ovarian carcinoma through ERK1/2 pathway.
Hu H, Wang Y, Dong Y, Wang L, Chen Y, Zhou Y, Sun L
Molecular biology reports 2023 Nov;50(11):8985-8993
Molecular biology reports 2023 Nov;50(11):8985-8993
Fusaric acid inhibits proliferation and induces apoptosis through triggering endoplasmic reticulum stress in MCF-7 human breast cancer cells.
Zhang J, Yuan H, Li W, Chen S, Liu S, Li C, Yao X
Mycotoxin research 2023 Nov;39(4):347-364
Mycotoxin research 2023 Nov;39(4):347-364
Correlation of 3'-phosphoadenosine-5'-phosphosulfate synthase 1 (PAPSS1) expression with clinical parameters and prognosis in esophageal squamous cell carcinoma.
Zhu X, Zhu P, Chen X, Zhang L, Wu C, Zhang H, Shen X, Qi Y, Chen M, Wang S, Yi X
Histology and histopathology 2023 Nov;38(11):1327-1335
Histology and histopathology 2023 Nov;38(11):1327-1335
A Responsive Nanorobot Modulates Intracellular Zinc Homeostasis to Amplify Mitochondria-Targeted Phototherapy.
Zhou X, Zhou A, Tian Z, Chen W, Xu Y, Ning X, Chen K
Small (Weinheim an der Bergstrasse, Germany) 2023 Nov;19(45):e2302952
Small (Weinheim an der Bergstrasse, Germany) 2023 Nov;19(45):e2302952
Design and synthesis of 3,4-seco-lupane triterpene derivatives to resist myocardial ischemia-reperfusion injury by inhibiting oxidative stress-mediated mitochondrial dysfunction via the PI3K/AKT/HIF-1α axis.
Teng H, Wu D, Lu L, Gao C, Wang H, Zhao Y, Wang L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Nov;167:115452
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Nov;167:115452
The role of the Gas6/TAM signal pathway in the LPS-induced pulmonary epithelial cells injury.
Cheng Y, Yang X, Wang Y, Ding Q, Huang Y, Zhang C
Molecular immunology 2023 Nov;163:181-187
Molecular immunology 2023 Nov;163:181-187
Linderalactone mitigates diabetic cardiomyopathy in mice via suppressing the MAPK/ATF6 pathway.
Han X, Zhou W, Zhang J, Tu Y, Wei J, Zheng R, Zhu J, Xu D, Ying H, Wu G, Shi Q, Liang G
International immunopharmacology 2023 Nov;124(Pt B):110984
International immunopharmacology 2023 Nov;124(Pt B):110984
Arecoline hydrobromide suppresses PI3K/AKT pathway in rheumatoid arthritis synovial fibroblasts and relieves collagen-induced arthritis in mice.
He J, Lin X, Wang X, Lin T, Lyu S, Gao X, Chen J, Wang Q
International immunopharmacology 2023 Nov;124(Pt B):110925
International immunopharmacology 2023 Nov;124(Pt B):110925
3D Elastomeric Stent Functionalized with Antioxidative and Perivascular Tissue Regenerative Activities Ameliorated PVT Deprivation-Induced Vein Graft Failure.
Wang Y, Fu M, Xiao W, Zhao Y, Yuan P, Zhang X, Wu W
Advanced healthcare materials 2023 Nov;12(29):e2301247
Advanced healthcare materials 2023 Nov;12(29):e2301247
ADORA2A promotes proliferation and inhibits apoptosis through PI3K/AKT pathway activation in colorectal carcinoma.
Ran L, Mou X, Peng Z, Li X, Li M, Xu D, Yang Z, Sun X, Yin T
Scientific reports 2023 Nov 9;13(1):19477
Scientific reports 2023 Nov 9;13(1):19477
Ferulic acid ameliorates the quality of in vitro-aged bovine oocytes by suppressing oxidative stress and apoptosis.
Yin YJ, Zhang YH, Wang Y, Jiang H, Zhang JB, Liang S, Yuan B
Aging 2023 Nov 8;15(21):12497-12512
Aging 2023 Nov 8;15(21):12497-12512
TROP2-directed nanobody-drug conjugate elicited potent antitumor effect in pancreatic cancer.
Xu C, Zhu M, Wang Q, Cui J, Huang Y, Huang X, Huang J, Gai J, Li G, Qiao P, Zeng X, Ju D, Wan Y, Zhang X
Journal of nanobiotechnology 2023 Nov 6;21(1):410
Journal of nanobiotechnology 2023 Nov 6;21(1):410
Duck Tembusu virus NS3 protein induces apoptosis by activating the PERK/PKR pathway and mitochondrial pathway.
Pan Y, Cai W, Cheng A, Wang M, Huang J, Chen S, Yang Q, Wu Y, Sun D, Mao S, Zhu D, Liu M, Zhao X, Zhang S, Gao Q, Ou X, Tian B, Yin Z, Jia R
Journal of virology 2023 Nov 30;97(11):e0149723
Journal of virology 2023 Nov 30;97(11):e0149723
Hypoxic preconditioned MSCs-derived small extracellular vesicles for photoreceptor protection in retinal degeneration.
Sun Y, Sun Y, Chen S, Yu Y, Ma Y, Sun F
Journal of nanobiotechnology 2023 Nov 25;21(1):449
Journal of nanobiotechnology 2023 Nov 25;21(1):449
A prognostic risk model for programmed cell death and revealing TRIB3 as a promising apoptosis suppressor in renal cell carcinoma.
Fu Q, Yi B, Su Q, Huang Y, Wang L, Zhang Z
Aging 2023 Nov 22;15(22):13213-13238
Aging 2023 Nov 22;15(22):13213-13238
Erythropoietin suppresses osteoblast apoptosis and ameliorates steroid-induced necrosis of the femoral head in rats by inhibition of STAT1-caspase 3 signaling pathway.
Cai T, Chen S, Wu C, Lou C, Wang W, Lin C, Jiang H, Xu X
BMC musculoskeletal disorders 2023 Nov 17;24(1):894
BMC musculoskeletal disorders 2023 Nov 17;24(1):894
Toxic effects of bisphenol S on mice heart and human umbilical cord endothelial cells.
Luo H, Yang Y, Zhang H, Ren L, Han X, Lin Y, Wu M, Hou Y
Ecotoxicology and environmental safety 2023 Nov 15;267:115652
Ecotoxicology and environmental safety 2023 Nov 15;267:115652
Biomimetic Construction of Degradable DNAzyme-Loaded Nanocapsules for Self-Sufficient Gene Therapy of Pulmonary Metastatic Breast Cancer.
Jiang R, Li L, Li M
ACS nano 2023 Nov 14;17(21):22129-22144
ACS nano 2023 Nov 14;17(21):22129-22144
Polytetrafluorethylene microplastic particles mediated oxidative stress, inflammation, and intracellular signaling pathway alteration in human derived cell lines.
K C PB, Maharjan A, Acharya M, Lee D, Kusma S, Gautam R, Kwon JT, Kim C, Kim K, Kim H, Heo Y
The Science of the total environment 2023 Nov 1;897:165295
The Science of the total environment 2023 Nov 1;897:165295
Morusinol Extracted from Morus alba Inhibits Cell Proliferation and Induces Autophagy via FOXO3a Nuclear Accumulation-Mediated Cholesterol Biosynthesis Obstruction in Colorectal Cancer.
Zhang X, Dong Z, Yang Y, Liu C, Li J, Sun W, Zhu Y, Shen Y, Wang Z, Lü M, Cui H
Journal of agricultural and food chemistry 2023 Nov 1;71(43):16016-16031
Journal of agricultural and food chemistry 2023 Nov 1;71(43):16016-16031
Inhibition of endogenous hydrogen sulfide production suppresses the growth of nasopharyngeal carcinoma cells.
Wang DY, Zhang J, Li HX, Zhang YX, Jing MR, Cai CB, Wang D, Qi HW, Wang YZ, Chen HJ, Li T, Zhai YK, Ji XY, Wu DD
Molecular carcinogenesis 2023 May;62(5):652-664
Molecular carcinogenesis 2023 May;62(5):652-664
TREM2 Inhibits Tau Hyperphosphorylation and Neuronal Apoptosis via the PI3K/Akt/GSK-3β Signaling Pathway In vivo and In vitro.
Peng X, Guo H, Zhang X, Yang Z, Ruganzu JB, Yang Z, Wu X, Bi W, Ji S, Yang W
Molecular neurobiology 2023 May;60(5):2470-2485
Molecular neurobiology 2023 May;60(5):2470-2485
Alpha lipoamide inhibits diabetic kidney fibrosis via improving mitochondrial function and regulating RXRα expression and activation.
Zhang HF, Liu HM, Xiang JY, Zhou XC, Wang D, Chen RY, Tan WL, Liang LQ, Liu LL, Shi MJ, Zhang F, Xiao Y, Zhou YX, Zhang T, Tang L, Guo B, Wang YY
Acta pharmacologica Sinica 2023 May;44(5):1051-1065
Acta pharmacologica Sinica 2023 May;44(5):1051-1065
The pan-cancer analysis of the oncogenic role of FAM72A as a BRCA prognostic biomarker and immunotherapeutic target.
Xu Y, Hirachan S, Shen Y, Huang Q, Bhandari A, Xia E
Environmental toxicology 2023 May;38(5):1100-1117
Environmental toxicology 2023 May;38(5):1100-1117
Experimental study of the effects of absorbable gelatin sponge and non‑absorbable polyvinyl alcohol particle material used in transcatheter arterial embolization on liver tissues.
Liu J, Wang S, Xue X, Hu T, Peng X, Huang J, Zhou S
Experimental and therapeutic medicine 2023 May;25(5):229
Experimental and therapeutic medicine 2023 May;25(5):229
Inhibitory effect and mechanism of hirsuteine on NCI‑H1299 lung cancer cell lines.
Yun X, Qin H, Du B, Peng Y, Liu Y, Yang B
Oncology letters 2023 May;25(5):202
Oncology letters 2023 May;25(5):202
Lyn attenuates sepsis-associated acute kidney injury by inhibition of phospho-STAT3 and apoptosis.
Li N, Lin G, Zhang H, Sun J, Gui M, Liu Y, Li W, Zhan Z, Li Y, Pan S, Liu J, Tang J
Biochemical pharmacology 2023 May;211:115523
Biochemical pharmacology 2023 May;211:115523
Anionic liposomes prepared without organic solvents for effective siRNA delivery.
Han X, Lu Y, Xu Z, Chu Y, Ma X, Wu H, Zou B, Zhou G
IET nanobiotechnology 2023 May;17(3):269-280
IET nanobiotechnology 2023 May;17(3):269-280
CBL0137 activates ROS/BAX signaling to promote caspase-3/GSDME-dependent pyroptosis in ovarian cancer cells.
Yang C, Wang ZQ, Zhang ZC, Lou G, Jin WL
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 May;161:114529
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 May;161:114529
High uric acid aggravates apoptosis of lung epithelial cells induced by cigarette smoke extract through downregulating PRDX2 in chronic obstructive pulmonary disease.
Dong Y, Han F, Su Y, Sun B, Zhao W, Pan C
International immunopharmacology 2023 May;118:110056
International immunopharmacology 2023 May;118:110056
DNMT3A R882H mutation promotes acute leukemic cell survival by regulating glycolysis through the NRF2/NQO1 axis.
Chu X, Zhong L, Dan W, Wang X, Zhang Z, Liu Z, Lu Y, Shao X, Zhou Z, Chen S, Liu B
Cellular signalling 2023 May;105:110626
Cellular signalling 2023 May;105:110626
Cryptotanshinone induces apoptosis of activated hepatic stellate cells via modulating endoplasmic reticulum stress.
Hou XX, Li YW, Song JL, Zhang W, Liu R, Yuan H, Feng TT, Jiang ZY, Li WT, Zhu CL
World journal of gastroenterology 2023 May 7;29(17):2616-2627
World journal of gastroenterology 2023 May 7;29(17):2616-2627
Red Ginseng Improves D-galactose-Induced Premature Ovarian Failure in Mice Based on Network Pharmacology.
Shang Z, Fan M, Zhang J, Wang Z, Jiang S, Li W
International journal of molecular sciences 2023 May 4;24(9)
International journal of molecular sciences 2023 May 4;24(9)
Inhibition of AGEs-RAGE-PP2A Axis Alleviates Cognitive Impairment after Chronic Heart Failure.
Li S, Wang L, Wang J, Liang B, Gao W, Huang Y, Deng B, Liu Q, Zhou Z, Zhang L, Xian S, Wang L, Liu J, Wang Z
Cellular and molecular biology (Noisy-le-Grand, France) 2023 May 31;69(5):179-185
Cellular and molecular biology (Noisy-le-Grand, France) 2023 May 31;69(5):179-185
The soluble guanylyl cyclase pathway is inhibited to evade androgen deprivation-induced senescence and enable progression to castration resistance.
Zhang L, Troccoli CI, Mateo-Victoriano B, Lincheta LM, Jackson E, Shu P, Plastini T, Tao W, Kwon D, Chen X, Sharma J, Jorda M, Gulley JL, Bilusic M, Lockhart AC, Beuve A, Rai P
bioRxiv : the preprint server for biology 2023 May 3;
bioRxiv : the preprint server for biology 2023 May 3;
Resveratrol Enhances Temozolomide Efficacy in Glioblastoma Cells through Downregulated MGMT and Negative Regulators-Related STAT3 Inactivation.
Wu M, Song D, Li H, Ahmad N, Xu H, Yang X, Wang Q, Cheng X, Deng S, Shu X
International journal of molecular sciences 2023 May 29;24(11)
International journal of molecular sciences 2023 May 29;24(11)
Chrysomycin A Regulates Proliferation and Apoptosis of Neuroglioma Cells via the Akt/GSK-3β Signaling Pathway In Vivo and In Vitro.
Liu DN, Liu M, Zhang SS, Shang YF, Zhang WF, Song FH, Zhang HW, Du GH, Wang YH
Marine drugs 2023 May 27;21(6)
Marine drugs 2023 May 27;21(6)
The Nrf2/HMGB1/NF-κB axis modulates chondrocyte apoptosis and extracellular matrix degradation in osteoarthritis.
Li W, Tao C, Mao M, Zhu K
Acta biochimica et biophysica Sinica 2023 May 26;55(5):818-830
Acta biochimica et biophysica Sinica 2023 May 26;55(5):818-830
Aristolocholic acid I promotes renal tubular epithelial fibrosis by upregulating matrix metalloproteinase-9 expression via activating the C3a/C3aR axis of macrophages.
Zhang Q, Ye J, Zhang Z, Hu Y, Wang X, Jiang W, Guo X, Chen L, Cheng S, Li J, Zhang L
Toxicology letters 2023 May 15;381:27-35
Toxicology letters 2023 May 15;381:27-35
Protective mechanism of gold nanoparticles on human neural stem cells injured by β-amyloid protein through miR-21-5p/SOCS6 pathway.
Wang G, Shen X, Song X, Wang N, Wo X, Gao Y
Neurotoxicology 2023 Mar;95:12-22
Neurotoxicology 2023 Mar;95:12-22
Electroacupuncture alleviates early brain injury via modulating microglia polarization and suppressing neuroinflammation in a rat model of subarachnoid hemorrhage.
Wang Y, Yang X, Cao Y, Li X, Xu R, Yan J, Guo Z, Sun S, Sun X, Wu Y
Heliyon 2023 Mar;9(3):e14475
Heliyon 2023 Mar;9(3):e14475
Loss of pleckstrin homology domain and leucine-rich repeat protein phosphatase 2 has protective effects on high glucose-injured retinal ganglion cells via the effect on the Akt-GSK-3β-Nrf2 pathway.
Liu X, Liu Y, Chen L, Zhang Z, Cui L, Wei T
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Mar;72(3):373-385
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Mar;72(3):373-385
Myricetin improves apoptosis after ischemic stroke via inhibiting MAPK-ERK pathway.
Zhang L, Zhou T, Ji Q, He L, Lan Y, Ding L, Li L, Wang Z
Molecular biology reports 2023 Mar;50(3):2545-2557
Molecular biology reports 2023 Mar;50(3):2545-2557
Ginsenoside compound K reduces ischemia/reperfusion-induced neuronal apoptosis by inhibiting PTP1B-mediated IRS1 tyrosine dephosphorylation.
Fu J, Yu L, Yu Q, Yu N, Xu F, Li S
Journal of ginseng research 2023 Mar;47(2):274-282
Journal of ginseng research 2023 Mar;47(2):274-282
The PERK/ATF4/CHOP signaling branch of the unfolded protein response mediates cisplatin-induced ototoxicity in hair cells.
Qu Y, Zong S, Wang Z, Du P, Wen Y, Li H, Wu N, Xiao H
Drug and chemical toxicology 2023 Mar;46(2):369-379
Drug and chemical toxicology 2023 Mar;46(2):369-379
CircTNPO3 promotes hepatocellular carcinoma progression by sponging miR-199b-5p and regulating STRN expression.
Liu J, Liu B
The Kaohsiung journal of medical sciences 2023 Mar;39(3):221-233
The Kaohsiung journal of medical sciences 2023 Mar;39(3):221-233
Pharmacological network analysis of the functions and mechanism of kaempferol from Du Zhong in intervertebral disc degeneration (IDD).
Wang X, Tan Y, Liu F, Wang J, Liu F, Zhang Q, Li J
Journal of orthopaedic translation 2023 Mar;39:135-146
Journal of orthopaedic translation 2023 Mar;39:135-146
Linear ubiquitination of LKB1 activates AMPK pathway to inhibit NLRP3 inflammasome response and reduce chondrocyte pyroptosis in osteoarthritis.
Chen Y, Liu Y, Jiang K, Wen Z, Cao X, Wu S
Journal of orthopaedic translation 2023 Mar;39:1-11
Journal of orthopaedic translation 2023 Mar;39:1-11
OASL knockdown inhibits the progression of stomach adenocarcinoma by regulating the mTORC1 signaling pathway.
Zhao W, Yang H, Liu L, Qu X, Ding J, Yu H, Xu B, Zhao S, Xi G, Xing L, Chai J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Mar;37(3):e22824
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Mar;37(3):e22824
Up-regulation of STRA6 predicts poor prognosis and contributes to oxaliplatin resistance in colorectal cancer.
Yang F, Xu P, Yao S, Li M, Bian Z, Huang Z
Pathology, research and practice 2023 Mar;243:154352
Pathology, research and practice 2023 Mar;243:154352
Decreased AGGF1 facilitates the progression of placenta accreta spectrum via mediating the P53 signaling pathway under the regulation of miR-1296-5p.
Wang R, Zhao J, Liu C, Li S, Liu W, Cao Q
Reproductive biology 2023 Mar;23(1):100735
Reproductive biology 2023 Mar;23(1):100735
Cyclin-dependent kinase subunit2 (CKS2) promotes malignant phenotypes and epithelial-mesenchymal transition-like process in glioma by activating TGFβ/SMAD signaling.
Feng F, Zhao Z, Cai X, Heng X, Ma X
Cancer medicine 2023 Mar;12(5):5889-5907
Cancer medicine 2023 Mar;12(5):5889-5907
Plumbagin induces the apoptosis of drug-resistant oral cancer in vitro and in vivo through ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction.
Lin CL, Yu CI, Lee TH, Chuang JM, Han KF, Lin CS, Huang WP, Chen JY, Chen CY, Lin MY, Lee CH
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Mar;111:154655
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Mar;111:154655
Ursolic Acid Suppresses Colorectal Cancer by Down-Regulation of Wnt/β-Catenin Signaling Pathway Activity.
Zhao H, Tang S, Tao Q, Ming T, Lei J, Liang Y, Peng Y, Wang M, Liu M, Yang H, Ren S, Xu H
Journal of agricultural and food chemistry 2023 Mar 8;71(9):3981-3993
Journal of agricultural and food chemistry 2023 Mar 8;71(9):3981-3993
Autophagy-Targeted Calcium Phosphate Nanoparticles Enable Transarterial Chemoembolization for Enhanced Cancer Therapy.
Yuan G, Xu Y, Bai X, Wang W, Wu X, Chen J, Li J, Jia X, Gu Z, Zhang X, Hu W, Wang J, Liu Y, Zhu XM
ACS applied materials & interfaces 2023 Mar 8;15(9):11431-11443
ACS applied materials & interfaces 2023 Mar 8;15(9):11431-11443
The Wnt/β-catenin pathway regulates inflammation and apoptosis in ventilator-induced lung injury.
Chen Z, He S, Lian S, Shen Y, Jiang W, Zhou L, Zhou L, Zhang X
Bioscience reports 2023 Mar 31;43(3)
Bioscience reports 2023 Mar 31;43(3)
PTMA binds to HMGB1 to regulate mitochondrial oxidative phosphorylation and thus affect the malignant progression of esophageal squamous cell carcinoma.
Chen S, He R, Lin X, Zhang W, Chen H, Xu R, Kang M
Journal of thoracic disease 2023 Mar 31;15(3):1302-1318
Journal of thoracic disease 2023 Mar 31;15(3):1302-1318
The effects of the prognostic biomarker SAAL1 on cancer growth and its association with the immune microenvironment in lung adenocarcinoma.
Tong S, Jiang N, Wan JH, Chen CR, Wang SH, Wu CY, Guo Q, Xiao XY, Huang H, Zhou T
BMC cancer 2023 Mar 27;23(1):275
BMC cancer 2023 Mar 27;23(1):275
ZNF582 overexpression restrains the progression of clear cell renal cell carcinoma by enhancing the binding of TJP2 and ERK2 and inhibiting ERK2 phosphorylation.
Yang W, Zhang Z, Li L, Zhang K, Xu Y, Xia M, Zhou J, Gong Y, Chen J, Gong K
Cell death & disease 2023 Mar 25;14(3):212
Cell death & disease 2023 Mar 25;14(3):212
Astaxanthin Alleviates Aflatoxin B1-Induced Oxidative Stress and Apoptosis in IPEC-J2 Cells via the Nrf2 Signaling Pathway.
Tian Y, Che H, Yang J, Jin Y, Yu H, Wang C, Fu Y, Li N, Zhang J
Toxins 2023 Mar 21;15(3)
Toxins 2023 Mar 21;15(3)
Human umbilical cord mesenchymal stem cells conditioned medium exerts anti-tumor effects on KGN cells in a cell density-dependent manner through activation of the Hippo pathway.
Wan W, Miao Y, Niu Y, Zhu K, Ma Y, Pan M, Ma B, Wei Q
Stem cell research & therapy 2023 Mar 20;14(1):46
Stem cell research & therapy 2023 Mar 20;14(1):46
AAZ2 induces mitochondrial-dependent apoptosis by targeting PDK1 in gastric cancer.
Li Y, She W, Xu X, Liu Y, Wang X, Tian S, Li S, Wang M, Yu C, Liu P, Huang T, Wei Y
Journal of Zhejiang University. Science. B 2023 Mar 15;24(3):232-247
Journal of Zhejiang University. Science. B 2023 Mar 15;24(3):232-247
Low-density small extracellular vesicles in bovine follicular fluid carrying let-7i target FASLG to inhibit granulosa cells apoptosis.
Zhao Y, Wang Y, Ling Z, Xue Y, Luan D, Kang J, Zhang Y, Quan F
Theriogenology 2023 Mar 15;199:121-130
Theriogenology 2023 Mar 15;199:121-130
Fam72a functions as a cell-cycle-controlled gene during proliferation and antagonizes apoptosis through reprogramming PP2A substrates.
Fu Y, Jia X, Yuan J, Yang Y, Zhang T, Yu Q, Zhou J, Wang T
Developmental cell 2023 Mar 13;58(5):398-415.e7
Developmental cell 2023 Mar 13;58(5):398-415.e7
Mir-153-3p Modulates the Breast Cancer Cells' Chemosensitivity to Doxorubicin by Targeting KIF20A.
Rahman KU, Yang S, Azam N, Yuan Z, Yu J, Zhao C, Feng B
Cancers 2023 Mar 11;15(6)
Cancers 2023 Mar 11;15(6)
Exploring the potential of ginseng glycoprotein to improve learning and memory in mice via Notch signaling pathway and structural analysis using multi-information fusion based on liquid chromatography-mass spectrometry.
Fang X, Zhang X, Zhang Y, Zhang X, Shan M, Guan S, Qiu Z, Zhu D, Luo H
Journal of ethnopharmacology 2023 Mar 1;303:115978
Journal of ethnopharmacology 2023 Mar 1;303:115978
Aidi injection enhances the anti-tumor impact of doxorubicin in H22 tumor-containing mice.
Lu Y, Zhang S, Zhu X, Wang K, He Y, Liu C, Sun J, Pan J, Zheng L, Liu W, Li Y, Huang Y, Liu T
Journal of ethnopharmacology 2023 Mar 1;303:115968
Journal of ethnopharmacology 2023 Mar 1;303:115968
Zearalenone induces oxidative stress and autophagy in goat Sertoli cells.
Liu X, Xi H, Han S, Zhang H, Hu J
Ecotoxicology and environmental safety 2023 Mar 1;252:114571
Ecotoxicology and environmental safety 2023 Mar 1;252:114571
IFT20 Confers Paclitaxel Resistance by Triggering β-arrestin-1 to Modulate ASK1 Signaling in Breast Cancer.
Qiu N, Jin H, Cui L, Zhan YT, Xia HM, Jiang M, Zhou J, Liang HL, Ao X, He ZM, Li HS
Molecular cancer research : MCR 2023 Mar 1;21(3):214-227
Molecular cancer research : MCR 2023 Mar 1;21(3):214-227
Git1-PGK1 interaction achieves self-protection against spinal cord ischemia-reperfusion injury by modulating Keap1/Nrf2 signaling.
Xu T, Gao P, Huang Y, Wu M, Yi J, Zhou Z, Zhao X, Jiang T, Liu H, Qin T, Yang Z, Wang X, Bao T, Chen J, Zhao S, Yin G
Redox biology 2023 Jun;62:102682
Redox biology 2023 Jun;62:102682
taVNS Alleviates Sevoflurane-Induced Cognitive Dysfunction in Aged Rats Via Activating Basal Forebrain Cholinergic Neurons.
Zhou Q, Zheng Z, Wang X, Li W, Wang L, Yin C, Zhang Q, Wang Q
Neurochemical research 2023 Jun;48(6):1848-1863
Neurochemical research 2023 Jun;48(6):1848-1863
1,25-Dihydroxvitamin D3 attenuates the damage of human immortalised keratinocytes caused by Ultraviolet-B.
Wang P, Liu D, Cui J, Yan S, Liang Y, Chen Q, Liu Y, Ren S, Chen P
Cutaneous and ocular toxicology 2023 Jun;42(2):74-81
Cutaneous and ocular toxicology 2023 Jun;42(2):74-81
Silencing of FAM111B inhibits tumor growth and promotes apoptosis by decreasing AKT activity in ovarian cancer.
Wang W, Gu Y, Ni H, Quan Q, Guo L
Experimental biology and medicine (Maywood, N.J.) 2023 Jun;248(12):1043-1055
Experimental biology and medicine (Maywood, N.J.) 2023 Jun;248(12):1043-1055
Sulconazole Induces PANoptosis by Triggering Oxidative Stress and Inhibiting Glycolysis to Increase Radiosensitivity in Esophageal Cancer.
Liu LX, Heng JH, Deng DX, Zhao H, Zheng ZY, Liao LD, Lin W, Xu XE, Li EM, Xu LY
Molecular & cellular proteomics : MCP 2023 Jun;22(6):100551
Molecular & cellular proteomics : MCP 2023 Jun;22(6):100551
HCH6-1, an antagonist of formyl peptide receptor-1, exerts anti-neuroinflammatory and neuroprotective effects in cellular and animal models of Parkinson's disease.
Wang HL, Cheng YC, Yeh TH, Liu HF, Weng YH, Chen RS, Chen YC, Lu JC, Hwang TL, Wei KC, Liu YC, Wang YT, Hsu CC, Chiu TJ, Chiu CC
Biochemical pharmacology 2023 Jun;212:115524
Biochemical pharmacology 2023 Jun;212:115524
Toosendanin-induced apoptosis of CMT-U27 is mediated through the mitochondrial apoptotic pathway.
Yang Y, Mei C, Xian H, Zhang X, Li J, Liang ZX, Zhi Y, Ma Y, Wang HJ
Veterinary and comparative oncology 2023 Jun;21(2):315-326
Veterinary and comparative oncology 2023 Jun;21(2):315-326
Excessive ER-phagy contributes to ochratoxin A-induced apoptosis.
Deng H, Chen W, Zhang B, Zhang Y, Han L, Zhang Q, Yao S, Wang H, Shen XL
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jun;176:113793
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jun;176:113793
HDAC inhibitor HPTA initiates anti-tumor response by CXCL9/10-recruited CXCR3(+)CD4(+)T cells against PAHs carcinogenicity.
Chen C, Lim D, Cai Z, Zhang F, Liu G, Dong C, Feng Z
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jun;176:113783
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jun;176:113783
miR-30c-2-3p suppresses the proliferation of human renal cell carcinoma cells by targeting TOP2A.
Huang X, Jia Y, Shi H, Fan H, Sun L, Zhang H, Wang Y, Chen J, Han J, Wang M, Du J, Zhang J
Asian biomedicine : research, reviews and news 2023 Jun;17(3):124-135
Asian biomedicine : research, reviews and news 2023 Jun;17(3):124-135
Aloe-emodin ameliorated MI-induced cardiac remodeling in mice via inhibiting TGF-β/SMAD signaling via up-regulating SMAD7.
Yu J, Zhao X, Yan X, Li W, Liu Y, Wang J, Wang J, Yang Y, Hao Y, Liang Z, Tao Y, Yuan Y, Du Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154793
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154793
Potential Mechanisms of Metformin-Induced Apoptosis in HeLa Cells.
Chu Z, Tan Y, Xu C, Zhangsun D, Zhu X
Biomolecules 2023 Jun 6;13(6)
Biomolecules 2023 Jun 6;13(6)
C11orf54 promotes DNA repair via blocking CMA-mediated degradation of HIF1A.
Tan J, Wang W, Liu X, Xu J, Che Y, Liu Y, Hu J, Hu L, Li J, Zhou Q
Communications biology 2023 Jun 5;6(1):606
Communications biology 2023 Jun 5;6(1):606
Codelivery of TRAIL and Mitomycin C via Liposomes Shows Improved Antitumor Effect on TRAIL-Resistant Tumors.
Chang R, Fu R, Huang Y, Zhang J, Feng C, Wang R, Yan H, Li G, Chu X, Yuan F, Jia D, Li J
Molecular pharmaceutics 2023 Jun 5;20(6):2864-2875
Molecular pharmaceutics 2023 Jun 5;20(6):2864-2875
Risk signature identification and NPRL2 affects sunitinib sensitivity in clear cell renal cell carcinoma.
Du X, Zhao Z, Zhao X, Wang H, Jiang L, Tang W
Biochemical and biophysical research communications 2023 Jun 30;663:122-131
Biochemical and biophysical research communications 2023 Jun 30;663:122-131
METTL3-mediated m(6)A modification of IGFBP7-OT promotes osteoarthritis progression by regulating the DNMT1/DNMT3a-IGFBP7 axis.
Tang Y, Hong F, Ding S, Yang J, Zhang M, Ma Y, Zheng Q, Yang D, Jin Y, Ma C
Cell reports 2023 Jun 27;42(6):112589
Cell reports 2023 Jun 27;42(6):112589
EZH2 Gene Knockdown Inhibits Sheep Pituitary Cell Proliferation via Downregulating the AKT/ERK Signaling Pathway.
Cai Y, Chen P, Xu H, Li S, Zhao B, Fan Y, Wang F, Zhang Y
International journal of molecular sciences 2023 Jun 26;24(13)
International journal of molecular sciences 2023 Jun 26;24(13)
Synergism Antiproliferative Effects of Apigenin and Naringenin in NSCLC Cells.
Liu X, Zhao T, Shi Z, Hu C, Li Q, Sun C
Molecules (Basel, Switzerland) 2023 Jun 23;28(13)
Molecules (Basel, Switzerland) 2023 Jun 23;28(13)
Effect of Lactobacillus delbrueckii subsp. lactis on vaginal radiotherapy for gynecological cancer.
Bi Z, Wang Q, Yang T, Liu Y, Yuan J, Li L, Guo Y
Scientific reports 2023 Jun 21;13(1):10105
Scientific reports 2023 Jun 21;13(1):10105
A multi-bioresponsive self-assembled nano drug delivery system based on hyaluronic acid and geraniol against liver cancer.
Duan S, Xia Y, Tian X, Cui J, Zhang X, Yang Q, Zhao T, Lin Y, Zhang F, Zhang X, Cen J
Carbohydrate polymers 2023 Jun 15;310:120695
Carbohydrate polymers 2023 Jun 15;310:120695
Acupuncture regulates the apoptosis of ovarian granulosa cells in polycystic ovarian syndrome-related abnormal follicular development through LncMEG3-mediated inhibition of miR-21-3p.
Chen X, He H, Long B, Wei B, Yang P, Huang X, Wang Q, Lin J, Tang H
Biological research 2023 Jun 12;56(1):31
Biological research 2023 Jun 12;56(1):31
Granulosa cells undergo BPA-induced apoptosis in a miR-21-independent manner.
Sabry R, Williams M, LaMarre J, Favetta LA
Experimental cell research 2023 Jun 1;427(1):113574
Experimental cell research 2023 Jun 1;427(1):113574
DR1-CSE/H(2)S pathway upregulates autophagy and inhibits H9C2 cells damage induced by high glucose.
Li H, Wei Y, Xi Y, Jiao L, Wen X, Wu R, Chang G, Sun F, Hao J
Acta cardiologica 2023 Jul;78(5):594-606
Acta cardiologica 2023 Jul;78(5):594-606
Natural Oncolysis of Enterovirus 71 in Antitumor Therapy of Colorectal Cancer.
Ruan Z, Chi J, Kong Y, Li C, Ruan X, Zhou X, Chen Y, Li Y, Luo Z
Advanced biology 2023 Jul;7(7):e2200336
Advanced biology 2023 Jul;7(7):e2200336
USP51/PD-L1/ITGB1-deployed juxtacrine interaction plays a cell-intrinsic role in promoting chemoresistant phenotypes in non-small cell lung cancer.
Li J, Xiao X, Ou Y, Cao L, Guo M, Qi C, Wang Z, Liu Y, Shuai Q, Wang H, Sun P, Shi Y, Yang G, Yang S
Cancer communications (London, England) 2023 Jul;43(7):765-787
Cancer communications (London, England) 2023 Jul;43(7):765-787
Circular forms of dedicator of cytokinesis 1 promotes breast cancer progression by derepressing never in mitosis related kinase 2 via sponging miR-128-3p.
Ni Z, Liu W, Pan G, Mao A, Liu J, Zhang Q, Li J, Liu L, Li H
Environmental toxicology 2023 Jul;38(7):1712-1722
Environmental toxicology 2023 Jul;38(7):1712-1722
Destruction of the cellular antioxidant pool contributes to resveratrol-induced senescence and apoptosis in lung cancer.
Liang C, Yi K, Zhou X, Li X, Zhong C, Cao H, Xie C, Zhu J
Phytotherapy research : PTR 2023 Jul;37(7):2995-3008
Phytotherapy research : PTR 2023 Jul;37(7):2995-3008
A mitochondria-targeting ROS-activated nanoprodrug for self-augmented antitumor oxidation therapy.
Zeng Z, Luo Y, Xu X, Shan T, Chen M, Huang Z, Huang Y, Zhao C
Journal of controlled release : official journal of the Controlled Release Society 2023 Jul;359:415-427
Journal of controlled release : official journal of the Controlled Release Society 2023 Jul;359:415-427
A role for fibroblast-derived SASP factors in the activation of pyroptotic cell death in mammary epithelial cells.
Hom LM, Sun S, Campbell J, Liu P, Culbert S, Murphy IM, Schafer ZT
The Journal of biological chemistry 2023 Jul;299(7):104922
The Journal of biological chemistry 2023 Jul;299(7):104922
Palmitic acid-induced ferroptosis via CD36 activates ER stress to break calcium-iron balance in colon cancer cells.
Kuang H, Sun X, Liu Y, Tang M, Wei Y, Shi Y, Li R, Xiao G, Kang J, Wang F, Peng J, Xu H, Zhou F
The FEBS journal 2023 Jul;290(14):3664-3687
The FEBS journal 2023 Jul;290(14):3664-3687
Fenofibrate attenuates the cytotoxic effect of cisplatin on lung cancer cells by enhancing the antioxidant defense system in vitro.
Kogami M, Abe S, Nakamura H, Aoshiba K
Oncology letters 2023 Jul;26(1):313
Oncology letters 2023 Jul;26(1):313
Coffee prevents IQ-induced liver damage by regulating oxidative stress, inflammation, endoplasmic reticulum stress, autophagy, apoptosis, and the MAPK/NF-κB signaling pathway in zebrafish.
Li D, Li Z, Dong L, Zhang Y, Lu Y, Wang J, Sun H, Wang S
Food research international (Ottawa, Ont.) 2023 Jul;169:112946
Food research international (Ottawa, Ont.) 2023 Jul;169:112946
Vitamin B12 alleviates myocardial ischemia/reperfusion injury via the SIRT3/AMPK signaling pathway.
Qin Y, Shi Y, Yu Q, Yang S, Wang Y, Dai X, Li G, Cheng Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jul;163:114761
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jul;163:114761
A novel organic arsenic derivative MZ2 remodels metabolism and triggers mtROS-mediated apoptosis in acute myeloid leukemia.
Chen G, She W, Yu C, Rouzi T, Li X, Ma L, Zhang N, Jiang H, Liu X, Wu J, Wang Q, Shen H, Zhou F
Journal of cancer research and clinical oncology 2023 Jul;149(8):4225-4242
Journal of cancer research and clinical oncology 2023 Jul;149(8):4225-4242
Dipeptidyl peptidase 3 is essential for maintaining osteoblastic differentiation under a high-glucose environment by inhibiting apoptosis, oxidative stress and inflammation through the modulation of the Keap1-Nrf2 pathway.
Li X, Yu X, He S, Li J
International immunopharmacology 2023 Jul;120:110404
International immunopharmacology 2023 Jul;120:110404
The protective effect of lncRNA NEAT1/miR-122-5p/Wnt1 axis on hippocampal damage in hepatic ischemic reperfusion young mice.
Dong Z, Jia L, Han W, Wang Y, Sheng M, Ren Y, Weng Y, Li H, Yu W
Cellular signalling 2023 Jul;107:110668
Cellular signalling 2023 Jul;107:110668
Hydrogen sulfide alleviates mitochondrial damage and ferroptosis by regulating OPA3-NFS1 axis in doxorubicin-induced cardiotoxicity.
Wang Y, Ying X, Wang Y, Zou Z, Yuan A, Xiao Z, Geng N, Qiao Z, Li W, Lu X, Pu J
Cellular signalling 2023 Jul;107:110655
Cellular signalling 2023 Jul;107:110655
Downregulated CAV-1 in mouse spinal cord may alleviate bone cancer pain by inhibiting the ERK/CREB pathway.
Ge J, Song J, Sun B, Yang X, Du B, Sun X, Zhang J, Ge J, Xie H
Mutation research 2023 Jul-Dec;827:111829
Mutation research 2023 Jul-Dec;827:111829
Defective efferocytosis by aged macrophages promotes STING signaling mediated inflammatory liver injury.
Hu H, Cheng X, Li F, Guan Z, Xu J, Wu D, Gao Y, Zhan X, Wang P, Zhou H, Rao Z, Cheng F
Cell death discovery 2023 Jul 8;9(1):236
Cell death discovery 2023 Jul 8;9(1):236
DSC2 suppresses the growth of gastric cancer through the inhibition of nuclear translocation of γ-catenin and PTEN/PI3K/AKT signaling pathway.
Sun C, Wen K, Zhang B, Dong Y, Chen C, Neo SY, Leng B, Gao TT, Wu J
Aging 2023 Jul 8;15(13):6380-6399
Aging 2023 Jul 8;15(13):6380-6399
Design, synthesis, and SAR study of novel flavone 1,2,4-oxadiazole derivatives with anti-inflammatory activities for the treatment of Parkinson's disease.
Shen ZB, Meng HW, Meng XS, Lv ZK, Fang MY, Zhang LL, Lv ZL, Li MS, Liu AK, Han JH, Li QS, Duan YJ
European journal of medicinal chemistry 2023 Jul 5;255:115417
European journal of medicinal chemistry 2023 Jul 5;255:115417
Downregulation of CLDN6 inhibits cell migration and invasion and promotes apoptosis by regulation of the JAK2/STAT3 signaling pathway in hepatocellular carcinoma.
He Z, Fan F, Xu Z, Zhang M, Zhao R, Ke X, Wang Q, Yan S, Zheng H
Translational cancer research 2023 Jul 31;12(7):1753-1764
Translational cancer research 2023 Jul 31;12(7):1753-1764
Effects of the Overexpression of Progesterone Receptors on a Precancer p53 and Rb-Defective Human Fallopian Tube Epithelial Cell Line.
Chang YH, Wu KC, Wang KH, Ding DC
International journal of molecular sciences 2023 Jul 23;24(14)
International journal of molecular sciences 2023 Jul 23;24(14)
Neuroprotective effect of a medium-chain triglyceride ketogenic diet on MPTP-induced Parkinson's disease mice: a combination of transcriptomics and metabolomics in the substantia nigra and fecal microbiome.
Zhang W, Chen S, Huang X, Tong H, Niu H, Lu L
Cell death discovery 2023 Jul 17;9(1):251
Cell death discovery 2023 Jul 17;9(1):251
Alkaloids from Piper longum Exhibit Anti-inflammatory Activity and Synergistic Effects with Chemotherapeutic Agents against Cervical Cancer Cells.
Wan Q, Xu J, Zhu C, Liu X, Tu Y, Lei J, Yu J
Journal of agricultural and food chemistry 2023 Jul 12;71(27):10349-10360
Journal of agricultural and food chemistry 2023 Jul 12;71(27):10349-10360
Gut microbiota contribute to Methamphetamine-induced cardiotoxicity in mouse model.
Liu Y, Chen LJ, Li XW, Yang JZ, Liu JL, Zhang KK, Li JH, Wang Q, Xu JT, Zhi X
Chemico-biological interactions 2023 Jul 1;379:110512
Chemico-biological interactions 2023 Jul 1;379:110512
Stat3 shRNA delivery with folate receptor-modified multi-functionalized graphene oxide particles for combined infrared radiation and gene therapy in hepatocellular carcinoma.
Chen X, Zhang L, Wang X, Xu L, Sun J, Liu Y, Liu X, Kalvakolanu DV, Guo B
Anti-cancer drugs 2023 Jul 1;34(6):715-724
Anti-cancer drugs 2023 Jul 1;34(6):715-724
Periplocin inhibits hepatocellular carcinoma progression and reduces the recruitment of MDSCs through AKT/NF-κB pathway.
Lin JP, Huang MH, Sun ZT, Chen L, Lei YH, Huang YQ, Qi M, Fan SR, Chen SG, Chung CW, Chan MC, Liu JS, Hu M, Chen MF, Ye WC, Chen YY, Deng LJ
Life sciences 2023 Jul 1;324:121715
Life sciences 2023 Jul 1;324:121715
Carnosic Acid Attenuates AβOs-Induced Apoptosis and Synaptic Impairment via Regulating NMDAR2B and Its Downstream Cascades in SH-SY5Y Cells.
Liu WY, Li Y, Li Y, Xu LZ, Jia JP
Molecular neurobiology 2023 Jan;60(1):133-144
Molecular neurobiology 2023 Jan;60(1):133-144
The hybrid oncolytic peptide NTP-385 potently inhibits adherent cancer cells by targeting the nucleus.
Yin H, Chen XT, Chi QN, Ma YN, Fu XY, Du SS, Qi YK, Wang KW
Acta pharmacologica Sinica 2023 Jan;44(1):201-210
Acta pharmacologica Sinica 2023 Jan;44(1):201-210
Anti-Postmenopausal osteoporosis effects of Isopsoralen: A bioinformatics-integrated experimental study.
Li H, Wang C, Jin Y, Cai Y, Yao J, Meng Q, Wu J, Wang H, Sun H, Liu M
Phytotherapy research : PTR 2023 Jan;37(1):231-251
Phytotherapy research : PTR 2023 Jan;37(1):231-251
6-Methoxydihydrosanguinarine induces apoptosis and autophagy in breast cancer MCF-7 cells by accumulating ROS to suppress the PI3K/AKT/mTOR signaling pathway.
Zhang L, Zhang X, Che D, Zeng L, Zhang Y, Nan K, Zhang X, Zhang H, Guo Z
Phytotherapy research : PTR 2023 Jan;37(1):124-139
Phytotherapy research : PTR 2023 Jan;37(1):124-139
Verniciflavanol A, a profisetinidin-type-4-arylflavan-3-ol from toxicodendron vernicifluum protects SH-SY5Y cells against H2O2-Induced oxidative stress.
Li M, Zhang Y, Han T, Guan L, Fan D, Wu Q, Liu J, Xu Y, Fan Y
Phytochemistry 2023 Jan;205:113487
Phytochemistry 2023 Jan;205:113487
Protective Mechanism of Ethyl Gallate against Intestinal Ischemia-Reperfusion Injury in Mice by in Vivo and in Vitro Studies Based on Transcriptomics.
Fan S, Feng X, Li K, Li B, Diao Y
Chemistry & biodiversity 2023 Jan;20(1):e202200643
Chemistry & biodiversity 2023 Jan;20(1):e202200643
CircSETD3 mediates acquired resistance to gefitinib in non-small lung cancer cells by FXR1/ECT2 pathway.
Wen C, Li Y, Huang Y, Wang N, He S, Bao M, Zhou H, Wu L
The international journal of biochemistry & cell biology 2023 Jan;154:106344
The international journal of biochemistry & cell biology 2023 Jan;154:106344
Koumine ameliorates concanavalin A-induced autoimmune hepatitis in mice: involvement of the Nrf2, NF-κB pathways, and gut microbiota.
Que W, Lin H, Li X, Zhang B, Liu M, Hu X, Fu J, Cheng Y, Qiu H
International immunopharmacology 2023 Jan;114:109573
International immunopharmacology 2023 Jan;114:109573
Methyl gallate prevents oxidative stress induced apoptosis and ECM degradation in chondrocytes via restoring Sirt3 mediated autophagy and ameliorates osteoarthritis progression.
Li Y, Shen B, Lv C, Zhu X, Naren Q, Xu D, Chen H, Wu F
International immunopharmacology 2023 Jan;114:109489
International immunopharmacology 2023 Jan;114:109489
Flammulina velutipes stem regulates oxidative damage and synthesis of yolk precursors in aging laying hens by regulating the liver-blood-ovary axis.
Wu H, Yuan J, Yin H, Jing B, Sun C, Nguepi Tsopmejio IS, Jin Z, Song H
Poultry science 2023 Jan;102(1):102261
Poultry science 2023 Jan;102(1):102261
Berberine enhances autophagic flux by activating the Nrf2 signaling pathway in bovine endometrial epithelial cells to resist LPS-induced apoptosis.
Fu K, Chen H, Mei L, Wang J, Gong B, Li Y, Cao R
Animal science journal = Nihon chikusan Gakkaiho 2023 Jan-Dec;94(1):e13847
Animal science journal = Nihon chikusan Gakkaiho 2023 Jan-Dec;94(1):e13847
Cathepsin B mediates the lysosomal-mitochondrial apoptosis pathway in arsenic-induced microglial cell injury.
Zhang Z, Pi R, Jiang Y, Ahmad M, Luo H, Luo J, Yang J, Sun B
Human & experimental toxicology 2023 Jan-Dec;42:9603271231172724
Human & experimental toxicology 2023 Jan-Dec;42:9603271231172724
Immunopotentiation effects of apigenin on NK cell proliferation and killing pancreatic cancer cells.
Feng YB, Chen L, Chen FX, Yang Y, Chen GH, Zhou ZH, Xu CF
International journal of immunopathology and pharmacology 2023 Jan-Dec;37:3946320231161174
International journal of immunopathology and pharmacology 2023 Jan-Dec;37:3946320231161174
Aa-Z2 triggers ROS-induced apoptosis of osteosarcoma by targeting PDK-1.
Liu Y, She W, Li Y, Wang M, Liu Y, Ning B, Xu T, Huang T, Wei Y
Journal of translational medicine 2023 Jan 7;21(1):7
Journal of translational medicine 2023 Jan 7;21(1):7
A Mulberry Diels-Alder-Type Adduct, Kuwanon M, Triggers Apoptosis and Paraptosis of Lung Cancer Cells through Inducing Endoplasmic Reticulum Stress.
Ma M, Luan X, Zheng H, Wang X, Wang S, Shen T, Ren D
International journal of molecular sciences 2023 Jan 5;24(2)
International journal of molecular sciences 2023 Jan 5;24(2)
Sulforaphane Suppresses H(2)O(2)-Induced Oxidative Stress and Apoptosis via the Activation of AMPK/NFE2L2 Signaling Pathway in Goat Mammary Epithelial Cells.
Shao D, Gao Z, Zhao Y, Fan M, Zhao X, Wei Q, Pan M, Ma B
International journal of molecular sciences 2023 Jan 5;24(2)
International journal of molecular sciences 2023 Jan 5;24(2)
Deficiency of S100A9 Alleviates Sepsis-Induced Acute Liver Injury through Regulating AKT-AMPK-Dependent Mitochondrial Energy Metabolism.
Zhang Y, Wu F, Teng F, Guo S, Li H
International journal of molecular sciences 2023 Jan 20;24(3)
International journal of molecular sciences 2023 Jan 20;24(3)
Stearate-derived very long-chain fatty acids are indispensable to tumor growth.
Chu Q, Liu P, Song Y, Yang R, An J, Zhai X, Niu J, Yang C, Li B
The EMBO journal 2023 Jan 16;42(2):e111268
The EMBO journal 2023 Jan 16;42(2):e111268
Endosulfan induced kidney cell injury by modulating ACE2 through up-regulating miR-429 in HK-2 cells.
Zhang B, Liu S, Sun Y, Xu D
Toxicology 2023 Jan 15;484:153392
Toxicology 2023 Jan 15;484:153392
Design, synthesis and anti-ovarian cancer activities of thieno[2,3-d]pyrimidine based chimeric BRD4 inhibitor/nitric oxide-donator.
Zhang Y, Pan Z, Chen C, Tan Y, Wang X, Wang L, Zhang L, Chen Y, He G
European journal of medicinal chemistry 2023 Jan 15;246:114970
European journal of medicinal chemistry 2023 Jan 15;246:114970
Discovery of rafoxanide as a novel agent for the treatment of non-small cell lung cancer.
Hu A, Liu J, Wang Y, Zhang M, Guo Y, Qin Y, Liu T, Men Y, Chen Q, Liu T
Scientific reports 2023 Jan 13;13(1):693
Scientific reports 2023 Jan 13;13(1):693
The Importance of the Immune System and Molecular Cell Signaling Pathways in the Pathogenesis and Progression of Lung Cancer.
Smok-Kalwat J, Mertowska P, Mertowski S, Smolak K, Kozińska A, Koszałka F, Kwaśniewski W, Grywalska E, Góźdź S
International journal of molecular sciences 2023 Jan 12;24(2)
International journal of molecular sciences 2023 Jan 12;24(2)
METTL3 Regulates Osteoclast Biological Behaviors via iNOS/NO-Mediated Mitochondrial Dysfunction in Inflammatory Conditions.
Li D, He J, Fang C, Zhang Y, He M, Zhang Z, Hou J, Xu Q
International journal of molecular sciences 2023 Jan 11;24(2)
International journal of molecular sciences 2023 Jan 11;24(2)
Dioscin reduced chemoresistance for colon cancer and analysis of sensitizing targets.
Li R, Qin J, Wang Z, Lv F, Guo J, Zhu H, Huang Y
Biochemical and biophysical research communications 2023 Jan 1;638:94-102
Biochemical and biophysical research communications 2023 Jan 1;638:94-102
ALKBH5 ALLEVIATES HYPOXIA POSTCONDITIONING INJURY IN d -GALACTOSE-INDUCED SENESCENT CARDIOMYOCYTES BY REGULATING STAT3.
Zhang X, Li F, Ma J, Zhang X, Yin Y
Shock (Augusta, Ga.) 2023 Jan 1;59(1):91-98
Shock (Augusta, Ga.) 2023 Jan 1;59(1):91-98
Aluminum exposure induces nephrotoxicity via fibrosis and apoptosis through the TGF-β1/Smads pathway in vivo and in vitro.
Wei H, Li D, Luo Y, Wang Y, Lin E, Wei X
Ecotoxicology and environmental safety 2023 Jan 1;249:114422
Ecotoxicology and environmental safety 2023 Jan 1;249:114422
FSH-inhibited autophagy protects against oxidative stress in goat Sertoli cells through p62-Nrf2 pathway.
Xi H, Hu Z, Han S, Liu X, Wang L, Hu J
Theriogenology 2023 Jan 1;195:103-114
Theriogenology 2023 Jan 1;195:103-114
Triptonide inhibits growth and metastasis in HCC by suppressing EGFR/PI3K/AKT signaling.
Zhang H, Mao Y, Zou X, Niu J, Jiang J, Chen X, Zhu M, Yang X, Dong T
Neoplasma 2023 Feb;70(1):94-102
Neoplasma 2023 Feb;70(1):94-102
Dysregulated B7H4/JAK2/STAT3 Pathway Involves in Hypertriglyceridemia Acute Pancreatitis and Is Attenuated by Baicalin.
Yang J, Han F, Wu G, Dong Y, Su H, Xu J, Li J
Digestive diseases and sciences 2023 Feb;68(2):478-486
Digestive diseases and sciences 2023 Feb;68(2):478-486
Elevated PGT promotes proliferation and inhibits cell apoptosis in preeclampsia by Erk signaling pathway.
Pang H, Lei D, Huang J, Guo Y, Fan C
Molecular and cellular probes 2023 Feb;67:101896
Molecular and cellular probes 2023 Feb;67:101896
G2 and S phase-expressed-1 induces chromosomal instability in esophageal squamous cell carcinoma cells and inhibits cell apoptosis through ROS/JNK signaling.
Zhang M, Wang X, Liu C, Zheng Z, Wan J, Yang Y, Chen S, Liu H
Molecular carcinogenesis 2023 Feb;62(2):122-134
Molecular carcinogenesis 2023 Feb;62(2):122-134
Curcumin alleviates ketamine-induced oxidative stress and apoptosis via Nrf2 signaling pathway in rats' cerebral cortex and hippocampus.
Zhang X, Cui Y, Song X, Jin X, Sheng X, Xu X, Li T, Chen H, Gao L
Environmental toxicology 2023 Feb;38(2):300-311
Environmental toxicology 2023 Feb;38(2):300-311
Combination of a New Oral Demethylating Agent, OR2100, and Venetoclax for Treatment of Acute Myeloid Leukemia.
Kamachi K, Ureshino H, Watanabe T, Yoshida-Sakai N, Fukuda-Kurahashi Y, Kawasoe K, Hoshiko T, Yamamoto Y, Kurahashi Y, Kimura S
Cancer research communications 2023 Feb;3(2):297-308
Cancer research communications 2023 Feb;3(2):297-308
Combination of chloroquine diphosphate and salidroside induces human liver cell apoptosis via regulation of mitochondrial dysfunction and autophagy.
Jiang B, Feng L, Yang T, Guo W, Li Y, Wang T, Liu C, Su H
Molecular medicine reports 2023 Feb;27(2)
Molecular medicine reports 2023 Feb;27(2)
Cyasterone inhibits IL-1β-mediated apoptosis and inflammation via the NF-κB and MAPK signaling pathways in rat chondrocytes and ameliorates osteoarthritisin vivo.
Teng L, Shen Y, Qu Y, Yang L, Yang Y, Jian X, Fan S, Zhang L, Fu Q
Chinese journal of natural medicines 2023 Feb;21(2):99-112
Chinese journal of natural medicines 2023 Feb;21(2):99-112
The organic arsenical-derived thioredoxin and glutathione system inhibitor ACZ2 induces apoptosis and autophagy in gastric cancer via ROS-dependent ER stress.
Li Y, She W, Guo T, Huang T, Liu Y, Liu P, Xu X, Wang X, Wang M, Yu C, Liu Y, Wei Y
Biochemical pharmacology 2023 Feb;208:115404
Biochemical pharmacology 2023 Feb;208:115404
Decreased expression and DNA hypermethylation of syncytin-1 in human villus tissues with unexplained recurrent spontaneous abortion.
Fu Y, Song Y, Zhang J, Wei LP, Sun XR
Journal of reproductive immunology 2023 Feb;155:103784
Journal of reproductive immunology 2023 Feb;155:103784
Melatonin reduces IL-33 and TSLP expression in human nasal epithelial cells by scavenging ROS directly.
Gong MJ, Zhang HB, Lou M, Wang YS, Ma RP, Hu ZZ, Zheng GX, Zhang Y
Immunity, inflammation and disease 2023 Feb;11(2):e788
Immunity, inflammation and disease 2023 Feb;11(2):e788
Low temperature exposure inhibits proliferation and induces apoptosis of bovine subcutaneous preadipocytes via p38 MAPK/JNK activation.
Li T, Bai H, Yang L, Hao W, Wei S, Yan P
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2023 Feb-Mar;264:110813
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2023 Feb-Mar;264:110813
Combination of DNA Damage, Autophagy, and ERK Inhibition: Novel Evodiamine-Inspired Multi-Action Pt(IV) Prodrugs with High-Efficiency and Low-Toxicity Antitumor Activity.
Liu XM, Li Z, Xie XR, Wang JQ, Qiao X, Qiao X, Xie CZ, Xu JY
Journal of medicinal chemistry 2023 Feb 9;66(3):1852-1872
Journal of medicinal chemistry 2023 Feb 9;66(3):1852-1872
Stress granules inhibit endoplasmic reticulum stress-mediated apoptosis during hypoxia-induced injury in acute liver failure.
Li WY, Yang F, Li X, Wang LW, Wang Y
World journal of gastroenterology 2023 Feb 28;29(8):1315-1329
World journal of gastroenterology 2023 Feb 28;29(8):1315-1329
Knockdown of MEF2D inhibits the development and progression of B-cell acute lymphoblastic leukemia.
Chang N, Feng J, Liao P, Hu Y, Li M, He Y, Li Y
Translational cancer research 2023 Feb 28;12(2):287-300
Translational cancer research 2023 Feb 28;12(2):287-300
LncGMDS-AS1 promotes the tumorigenesis of colorectal cancer through HuR-STAT3/Wnt axis.
Ye D, Liu H, Zhao G, Chen A, Jiang Y, Hu Y, Liu D, Xie N, Liang W, Chen X, Zhang H, Li C, Wang J, Sun D, Chen W, Tan D, Wang Q, Wang H, Yu D, Wu B, Wang M, Cui S, Liu S, Zhang X
Cell death & disease 2023 Feb 27;14(2):165
Cell death & disease 2023 Feb 27;14(2):165
The protective effect of the mitochondrial-derived peptide MOTS-c on LPS-induced septic cardiomyopathy.
Wu J, Xiao D, Yu K, Shalamu K, He B, Zhang M
Acta biochimica et biophysica Sinica 2023 Feb 25;55(2):285-294
Acta biochimica et biophysica Sinica 2023 Feb 25;55(2):285-294
A role for fibroblast-derived SASP factors in the activation of pyroptotic cell death in mammary epithelial cells.
Hom LM, Sun S, Campbell J, Liu P, Culbert S, Murphy IM, Schafer ZT
bioRxiv : the preprint server for biology 2023 Feb 22;
bioRxiv : the preprint server for biology 2023 Feb 22;
METTL14-dependent maturation of pri-miR-17 regulates mitochondrial homeostasis and induces chemoresistance in colorectal cancer.
Sun K, Chen L, Li Y, Huang B, Yan Q, Wu C, Lai Q, Fang Y, Cai J, Liu Y, Chen J, Wang X, Zhu Y, Dong S, Tan J, Li A, Liu S, Zhang Y
Cell death & disease 2023 Feb 21;14(2):148
Cell death & disease 2023 Feb 21;14(2):148
Iron overload modulates follicular microenvironment via ROS/HIF-1α/FSHR signaling.
Wu Y, Yang R, Lan J, Wu Y, Huang J, Fan Q, You Y, Lin H, Jiao X, Chen H, Cao C, Zhang Q
Free radical biology & medicine 2023 Feb 20;196:37-52
Free radical biology & medicine 2023 Feb 20;196:37-52
Identifying CDC7 as a synergistic target of chemotherapy in resistant small-cell lung cancer via CRISPR/Cas9 screening.
Deng L, Yang L, Zhu S, Li M, Wang Y, Cao X, Wang Q, Guo L
Cell death discovery 2023 Feb 2;9(1):40
Cell death discovery 2023 Feb 2;9(1):40
RTA dh404 Induces Cell Cycle Arrest, Apoptosis, and Autophagy in Glioblastoma Cells.
Tsai TH, Su YF, Tsai CY, Wu CH, Lee KT, Hsu YC
International journal of molecular sciences 2023 Feb 16;24(4)
International journal of molecular sciences 2023 Feb 16;24(4)
Exendin-4 alleviates myocardial ischemia reperfusion injury by enhancing autophagy through promoting nuclear translocation of TFEB.
He W, Tong G, Fan H, Zhen C, Zeng L, Xue L, Chen J, Sun Z, He P
Experimental cell research 2023 Feb 15;423(2):113469
Experimental cell research 2023 Feb 15;423(2):113469
To explore the regulatory role of Wnt/P53/Caspase3 signal in mouse ovarian development based on LFQ proteomics.
Ma Y, Du C, Xie X, Zhang Y, Wang C, Xu J, Xia G, Yang Y
Journal of proteomics 2023 Feb 10;272:104772
Journal of proteomics 2023 Feb 10;272:104772
Bumetanide Rescues Aquaporin-4 Depolarization via Suppressing β-Dystroglycan Cleavage and Provides Neuroprotection in Rat Retinal Ischemia-Reperfusion Injury.
Chen C, Fan P, Zhang L, Xue K, Hu J, Huang J, Lu W, Xu J, Xu S, Qiu G, Ran J, Gan S
Neuroscience 2023 Feb 1;510:95-108
Neuroscience 2023 Feb 1;510:95-108
Long noncoding RNA RMRP ameliorates doxorubicin-induced apoptosis by interacting with PFN1 in a P53-Dependent manner.
Li J, Zhou L, Jiang Y, Gao H, Maierhaba T, Gong H
Molecular and cellular probes 2023 Dec;72:101937
Molecular and cellular probes 2023 Dec;72:101937
TBC1 domain family member 25 protects against myocardial apoptosis and the proinflammatory response triggered by ischemia-reperfusion injury through suppression of the TAK1-JNK/p38 MAPK signaling cascade.
Liu Z, Shang F, Li N, Dong W
In vitro cellular & developmental biology. Animal 2023 Dec;59(10):796-810
In vitro cellular & developmental biology. Animal 2023 Dec;59(10):796-810
Selumetinib overcomes gefitinib primary and acquired resistance by regulating MIG6/STAT3 in NSCLC.
Song X, Wang L, Tang W, Yuan L, Liu Q, Li J, Fan D
Archives of pharmacal research 2023 Dec;46(11-12):924-938
Archives of pharmacal research 2023 Dec;46(11-12):924-938
ANXA3, associated with YAP1 regulation, participates in the proliferation and chemoresistance of cervical cancer cells.
Huang J, Wei W, Kang F, Tan S, Li Y, Lu X, Wang N
Genes & genomics 2023 Dec;45(12):1575-1586
Genes & genomics 2023 Dec;45(12):1575-1586
Integrating network pharmacology and experimental models to examine the mechanisms of corosolic acid in preventing hepatocellular carcinoma progression through activation PERK-eIF2a-ATF4 signaling.
Tang F, Peng Y, Liu J, Gao W, Xu Y
Naunyn-Schmiedeberg's archives of pharmacology 2023 Dec;396(12):3671-3682
Naunyn-Schmiedeberg's archives of pharmacology 2023 Dec;396(12):3671-3682
GALNT2, an O-glycosylating enzyme, is a critical regulator of radioresistance of non-small cell lung cancer: evidence from an integrated multi-omics analysis.
Dong X, Leng Y, Tian T, Hu Q, Chen S, Liu Y, Shen L
Cell biology and toxicology 2023 Dec;39(6):3159-3174
Cell biology and toxicology 2023 Dec;39(6):3159-3174
Endogenous hydrogen sulfide inhibition suppresses tumor growth by promoting apoptosis and pyroptosis in esophageal cancer cells.
Wang HG, Wang D, Sarfraz M, Afzal A, Jing MR, Zhang YX, Cai CB, Qi HW, Chen HJ, Li T, Hu SJ, Liu HX, Ji XY, Wu DD
Translational oncology 2023 Dec;38:101770
Translational oncology 2023 Dec;38:101770
miR-133a-3p regulates the growth of hair follicle stem cells in white goats from the Yangtze River Delta.
Wu X, Wang J, Kang Y, Wang Q, Qu J, Sun X, Ji D, Li Y
Animal biotechnology 2023 Dec;34(9):4559-4568
Animal biotechnology 2023 Dec;34(9):4559-4568
Bioinformatic analysis of the expression profile and identification of RhoGDI2 as a biomarker in imatinib-resistant K562 cells.
Yang Y, Zhong F, Jiang J, Li M, Yao F, Liu J, Cheng Y, Xu S, Chen S, Zhang H, Xu Y, Huang B
Hematology (Amsterdam, Netherlands) 2023 Dec;28(1):2244856
Hematology (Amsterdam, Netherlands) 2023 Dec;28(1):2244856
BNIP3 overexpression may promote myeloma cell apoptosis by enhancing sensitivity to bortezomib via the p38 MAPK pathway.
Xiao P, Chen X, Dong Z, Fan W, Chen Y, Su J, Wang Q, Ma L
Hematology (Amsterdam, Netherlands) 2023 Dec;28(1):2231739
Hematology (Amsterdam, Netherlands) 2023 Dec;28(1):2231739
Brusatol enhances MEF2A expression to inhibit RCC progression through the Wnt signalling pathway in renal cell carcinoma.
Wang T, Zhou Y, Bao H, Liu B, Wang M, Wang L, Pan T
Journal of cellular and molecular medicine 2023 Dec;27(23):3897-3910
Journal of cellular and molecular medicine 2023 Dec;27(23):3897-3910
Inhibiting NF-κB-S100A11 signaling and targeting S100A11 for anticancer effects of demethylzeylasteral in human colon cancer.
Li W, Han F, Tang K, Ding C, Xiong F, Xiao Y, Li C, Liang Q, Lee KY, Lee IS, Gao H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec;168:115725
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec;168:115725
LRRC8A promotes Glaesserella parasuis cytolethal distending toxin-induced p53-dependent apoptosis in NPTr cells.
Mao W, Wang Z, Wen S, Lin Y, Gu J, Sun J, Wang H, Cao Q, Xu Y, Xu X, Cai X
Virulence 2023 Dec;14(1):2287339
Virulence 2023 Dec;14(1):2287339
The novel CDK9 inhibitor, XPW1, alone and in combination with BRD4 inhibitor JQ1, for the treatment of clear cell renal cell carcinoma.
Kuang Z, Guo K, Cao Y, Jiang M, Wang C, Wu Q, Hu G, Ao M, Huang M, Qin J, Zhao T, Lu S, Sun C, Li M, Wu T, Liu W, Fang M
British journal of cancer 2023 Dec;129(12):1915-1929
British journal of cancer 2023 Dec;129(12):1915-1929
Multi-omics analysis reveals the mechanism of action of ophiopogonin D against pulmonary fibrosis.
Bao S, Chen T, Chen J, Zhang J, Zhang G, Hui Y, Li J, Yan S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Dec;121:155078
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Dec;121:155078
Comprehensive analysis of clinical prognosis and biological significance of CNIH4 in cervical cancer.
Wang J, Wang S, Wang J, Huang J, Lu H, Pan B, Pan H, Song Y, Deng Q, Jin X, Shi G
Cancer medicine 2023 Dec;12(24):22381-22394
Cancer medicine 2023 Dec;12(24):22381-22394
Probiotic-fermented Qushi decoction alleviates reserpine-induced spleen deficiency syndrome by regulating spleen function and gut microbiota dysbiosis.
Zeng W, Chen Y, Zhang H, Peng L, Li Y, Liu B, Liang H, Du B, Li P
Journal of the science of food and agriculture 2023 Dec;103(15):7702-7711
Journal of the science of food and agriculture 2023 Dec;103(15):7702-7711
RUNX1 knockdown induced apoptosis and impaired EMT in high-grade serous ovarian cancer cells.
Chen Y, He Z, Yang S, Chen C, Xiong W, He Y, Liu S
Journal of translational medicine 2023 Dec 6;21(1):886
Journal of translational medicine 2023 Dec 6;21(1):886
Pinocembrin attenuates susceptibility to atrial fibrillation in rats with pulmonary arterial hypertension.
Yi Y, Tianxin Y, Zhangchi L, Cui Z, Weiguo W, Bo Y
European journal of pharmacology 2023 Dec 5;960:176169
European journal of pharmacology 2023 Dec 5;960:176169
Discovery of 4-((3,4-dichlorophenyl)amino)-2-methylquinolin-6-ol derivatives as EGFR and HDAC dual inhibitors.
Qian Y, Zhou S, Li J, Ma M, Chen H, Cao Y, Zhang Y, Sun C, Li K, Liu Y, Dai S, Ao M, Fang M, Wu Z, Li M
European journal of pharmacology 2023 Dec 5;960:176114
European journal of pharmacology 2023 Dec 5;960:176114
Cynanchum komarovii extract for the treatment of rheumatoid arthritis by acting on synovial cells in vitro and in vivo.
Hao F, Tao L, Liu J, Ma Y, Zhang J, Wang W, Yan W, Wang B, Wang X, Chen X, Ma Y, Fan H, Zhao X, Wang Z, Bai C
Journal of ethnopharmacology 2023 Dec 5;317:116825
Journal of ethnopharmacology 2023 Dec 5;317:116825
Design, synthesis, and biological evaluation of novel 4,4'-bipyridine derivatives acting as CDK9-Cyclin T1 protein-protein interaction inhibitors against triple-negative breast cancer.
Gao G, Li J, Cao Y, Li X, Qian Y, Wang X, Li M, Qiu Y, Wu T, Wang L, Fang M
European journal of medicinal chemistry 2023 Dec 5;261:115858
European journal of medicinal chemistry 2023 Dec 5;261:115858
Protective Effect of Ginsenoside CK against Autoimmune Hepatitis Induced by Concanavalin A.
Zhang J, Liu Y, An C, Liu C, Ma S, Zhang Q, Ding H, Shao J, Xue W
Foods (Basel, Switzerland) 2023 Dec 5;12(24)
Foods (Basel, Switzerland) 2023 Dec 5;12(24)
TrxR/Trx inhibitor butaselen ameliorates pulmonary fibrosis by suppressing NF-κB/TGF-β1/Smads signaling.
Chen Y, Yin H, Sun J, Zhang G, Zhang Y, Zeng H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec 31;169:115822
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec 31;169:115822
Isoliquiritigenin Inhibits the Growth of Colorectal Cancer Cells through the ESR2/PI3K/AKT Signalling Pathway.
Luo F, Tang Y, Zheng L, Yang Y, Gao H, Tian S, Chen H, Tang C, Tang S, Man Q, Wu Y
Pharmaceuticals (Basel, Switzerland) 2023 Dec 27;17(1)
Pharmaceuticals (Basel, Switzerland) 2023 Dec 27;17(1)
Nanointegrative In Situ Reprogramming of Tumor-Intrinsic Lipid Droplet Biogenesis for Low-Dose Radiation-Activated Ferroptosis Immunotherapy.
Zhang Q, Wang X, Zhao Y, Cheng Z, Fang D, Liu Y, Tian G, Li M, Luo Z
ACS nano 2023 Dec 26;17(24):25419-25438
ACS nano 2023 Dec 26;17(24):25419-25438
Reduced Proteolipid Protein 2 promotes endoplasmic reticulum stress-related apoptosis and increases drug sensitivity in acute myeloid leukemia.
Xie F, Qu J, Lin D, Feng K, Tan M, Liao H, Zeng L, Xiong Q, Huang J, Chen W
Molecular biology reports 2023 Dec 12;51(1):10
Molecular biology reports 2023 Dec 12;51(1):10
Pectolinarigenin attenuates hepatic ischemia/reperfusion injury via activation of the PI3K/AKT/Nrf2 signaling pathway.
Li H, Chen Y, Ding M, Yan Z, Guo W, Guo R
Chemico-biological interactions 2023 Dec 1;386:110763
Chemico-biological interactions 2023 Dec 1;386:110763
Mouth breathing induces condylar remodelling and chondrocyte apoptosis via both the extrinsic and mitochondrial pathways in male adolescent rats.
Wang Y, Liu Z, Ma G, Xu Y, Li Y
Tissue & cell 2023 Aug;83:102146
Tissue & cell 2023 Aug;83:102146
TAGLN2 Promotes the Proliferation, Migration, Invasion, and EMT of Clear Cell Renal Cell Carcinoma Through the PI3K/Akt Signaling Pathway.
He Y, Zhang B, Han D, Du Y, Zhang X, Wang H, Yue Z, Shang P
Biochemical genetics 2023 Aug;61(4):1265-1281
Biochemical genetics 2023 Aug;61(4):1265-1281
Mechanism of ligusticum cycloprolactam against neuroinflammation based on network pharmacology and experimental verification.
Gao J, Su G, Chen W, Wu Q, Liu J, Liu J, Chai M, Dong Y, Wang H, Chen L, Zhang Z, Wang M
Clinical and experimental pharmacology & physiology 2023 Aug;50(8):647-663
Clinical and experimental pharmacology & physiology 2023 Aug;50(8):647-663
The MyD88 inhibitor, ST2825, induces cell cycle arrest and apoptosis by suppressing the activation of the NF‑κB/AKT1/p21 pathway in pancreatic cancer.
Lu S, He T, Zhang Y, Zhou B, Zhang Q, Yan S
Oncology reports 2023 Aug;50(2)
Oncology reports 2023 Aug;50(2)
TRAF6 regulates autophagy and apoptosis of melanoma cells through c-Jun/ATG16L2 signaling pathway.
Guo Y, Zhang X, Li J, Zhou Z, Zhu S, Liu W, Su J, Chen X, Peng C
MedComm 2023 Aug;4(4):e309
MedComm 2023 Aug;4(4):e309
Methylseleninic acid induces apoptosis of human bladder cancer cells through the ROS-mediated mitochondrial pathway.
Chen Y, Zhang Y, Wang X, Qiao S
Journal of biochemical and molecular toxicology 2023 Aug;37(8):e23387
Journal of biochemical and molecular toxicology 2023 Aug;37(8):e23387
A novel long noncoding RNA-lncRNA-AABR07066529.3 alleviates inflammation, apoptosis, and pyroptosis by inhibiting MyD88 in lipopolysaccharide-induced myocardial depression.
Wen R, Zhang TN, Zhang T, Tong YJ, Song WL, Liu YP, Yang N, Liu CF
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Aug;37(8):e23063
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Aug;37(8):e23063
Thymoquinone induces apoptosis and protective autophagy in gastric cancer cells by inhibiting the PI3K/Akt/mTOR pathway.
He P, He Y, Ma J, Liu Y, Liu C, Baoping Y, Dong W
Phytotherapy research : PTR 2023 Aug;37(8):3467-3480
Phytotherapy research : PTR 2023 Aug;37(8):3467-3480
miR-101-5p overexpression suppresses the proliferation of goat spermatogonial stem cells by targeting EZH2.
Cai Y, Liu Z, Zhang G, Yang Y, Zhang Y, Wang F, Deng M
Animal reproduction science 2023 Aug;255:107281
Animal reproduction science 2023 Aug;255:107281
Decreased PPP1R3G in pre-eclampsia impairs human trophoblast invasion and migration via Akt/MMP-9 signaling pathway.
Shi H, Kong R, Miao X, Gou L, Yin X, Ding Y, Cao X, Meng Q, Gu M, Suo F
Experimental biology and medicine (Maywood, N.J.) 2023 Aug;248(16):1373-1382
Experimental biology and medicine (Maywood, N.J.) 2023 Aug;248(16):1373-1382
Role of Autophagy and Apoptosis in Aluminum Exposure-Induced Liver Injury in Rats.
Wei X, Li D, Luo Y, Wu B
Biological trace element research 2023 Aug;201(8):3971-3980
Biological trace element research 2023 Aug;201(8):3971-3980
Profilin1 Regulates Trophoblast Invasion and Macrophage Differentiation.
Chen X, Song QL, Wang JY, Ji R, Li ZH, Cao ML, Mu XF, Guo DY, Zhang Y, Yang J
The American journal of pathology 2023 Aug;193(8):1059-1071
The American journal of pathology 2023 Aug;193(8):1059-1071
Armcx1 attenuates secondary brain injury in an experimental traumatic brain injury model in male mice by alleviating mitochondrial dysfunction and neuronal cell death.
Lu D, Wang Y, Liu G, Wang S, Duan A, Wang Z, Wang J, Sun X, Wu Y, Wang Z
Neurobiology of disease 2023 Aug;184:106228
Neurobiology of disease 2023 Aug;184:106228
MALAT1 binds to miR-188-3p to regulate ALOX5 activity in the lung inflammatory response of neonatal bronchopulmonary dysplasia.
Feng DD, Chen JH, Chen YF, Cao Q, Li BJ, Chen XQ, Jin R, Zhou GP
Molecular immunology 2023 Aug;160:67-79
Molecular immunology 2023 Aug;160:67-79
Astragaloside IV protects LO2 cells from oxidative damage caused by radiation-induced bystander effect through Akt/Nrf2 pathway.
Wan D, Zhu Z, Zhou J, Deng Z, Lei P, Liu Q, Sun X, Huang B
Toxicology research 2023 Aug;12(4):635-647
Toxicology research 2023 Aug;12(4):635-647
Multi-Catcher Polymers Regulate the Nucleolin Cluster on the Cell Surface for Cancer Therapy.
Cheng F, Jiang Y, Kong B, Lin H, Shuai X, Hu P, Gao P, Zhan L, Huang C, Li C
Advanced healthcare materials 2023 Aug;12(21):e2300102
Advanced healthcare materials 2023 Aug;12(21):e2300102
Manganese-induced apoptosis through the ROS-activated JNK/FOXO3a signaling pathway in CTX cells, a model of rat astrocytes.
Li WH, Xiang ZT, Lu AX, Wang SS, Yan CH
Ecotoxicology and environmental safety 2023 Aug 7;262:115326
Ecotoxicology and environmental safety 2023 Aug 7;262:115326
Histone acetylation by HBO1 (KAT7) activates Wnt/β-catenin signaling to promote leukemogenesis in B-cell acute lymphoblastic leukemia.
Wang H, Qiu Y, Zhang H, Chang N, Hu Y, Chen J, Hu R, Liao P, Li Z, Yang Y, Cen Q, Ding X, Li M, Xie X, Li Y
Cell death & disease 2023 Aug 4;14(8):498
Cell death & disease 2023 Aug 4;14(8):498
Cordycepin inhibits ERK pathway to suppress FGF9-induced tumorigenesis with MA-10 mouse Leydig tumor cells.
Chen LC, Chen CY, Lee YP, Huang BM
Journal of food and drug analysis 2023 Aug 31;31(3):485-501
Journal of food and drug analysis 2023 Aug 31;31(3):485-501
Free Fatty Acids Induce Apoptosis of Mammary Epithelial Cells of Ketotic Dairy Cows via the Mito-ROS/NLRP3 Signaling Pathway.
Chang R, Jia H, Dong Z, Xu Q, Liu L, Majigsuren Z, Batbaatar T, Xu C, Yang Q, Sun X
Journal of agricultural and food chemistry 2023 Aug 30;71(34):12645-12656
Journal of agricultural and food chemistry 2023 Aug 30;71(34):12645-12656
The cellular uptake of Cordyceps sinensis exopolysaccharide‑selenium nanoparticles and their induced apoptosis of HepG2 cells via mitochondria- and death receptor-mediated pathways.
Zhang X, Xiao Y, Huang Q
International journal of biological macromolecules 2023 Aug 30;247:125747
International journal of biological macromolecules 2023 Aug 30;247:125747
Neuroprotective Effects of Vinpocetine Against Ischemia-Reperfusion Injury Via Inhibiting NLRP3 Inflammasome Signaling Pathway.
Hou B, Li D, Wang D, Jiang C, Wang G, Wang D, Yan G, Guo X, Zhao L, Wan Z, Fan C, Cao W, Ren H
Neuroscience 2023 Aug 21;526:74-84
Neuroscience 2023 Aug 21;526:74-84
MFAP2 promotes the progression of oral squamous cell carcinoma by activating the Wnt/β-catenin signaling pathway through autophagy.
Zhang H, Shen S, Feng C, Chen G, Wang X
Acta biochimica et biophysica Sinica 2023 Aug 17;55(9):1445-1455
Acta biochimica et biophysica Sinica 2023 Aug 17;55(9):1445-1455
ADAMDEC1 induces EMT and promotes colorectal cancer cells metastasis by enhancing Wnt/β-catenin signaling via negative modulation of GSK-3β.
Jia Y, Huang X, Shi H, Wang M, Chen J, Zhang H, Hou D, Jing H, Du J, Han H, Zhang J
Experimental cell research 2023 Aug 15;429(2):113629
Experimental cell research 2023 Aug 15;429(2):113629
Salidroside alleviates acetaminophen-induced hepatotoxicity via Sirt1-mediated activation of Akt/Nrf2 pathway and suppression of NF-κB/NLRP3 inflammasome axis.
Gao Z, Zhan H, Zong W, Sun M, Linghu L, Wang G, Meng F, Chen M
Life sciences 2023 Aug 15;327:121793
Life sciences 2023 Aug 15;327:121793
Correction: Tang et al. Vitamin K2 Modulates Mitochondrial Dysfunction Induced by 6-Hydroxydopamine in SH-SY5Y Cells via Mitochondrial Quality-Control Loop. Nutrients 2022, 14, 1504.
Tang H, Zheng Z, Wang H, Wang L, Zhao G, Wang P
Nutrients 2023 Aug 11;15(16)
Nutrients 2023 Aug 11;15(16)
Intermittent fasting activates macrophage migration inhibitory factor and alleviates high-fat diet-induced nonalcoholic fatty liver disease.
Li D, Dun Y, Qi D, Ripley-Gonzalez JW, Dong J, Zhou N, Qiu L, Zhang J, Zeng T, You B, Liu S
Scientific reports 2023 Aug 11;13(1):13068
Scientific reports 2023 Aug 11;13(1):13068
Ubiquitin-specific protease 7 prevents recurrent spontaneous abortion by targeting enhancer of zeste homolog 2 to regulate trophoblast proliferation, apoptosis, migration, and invasion through the Wnt/β-catenin pathway†.
Zhou M, Gao Y, Wu S, Chen J, Ding J, Wang Y, Yang J
Biology of reproduction 2023 Aug 10;109(2):204-214
Biology of reproduction 2023 Aug 10;109(2):204-214
The effects and mechanism of LncRNA NORAD on doxorubicin-induced cardiotoxicity.
Guan X, Wang Y, Li W, Liu X, Jiang J, Bian W, Xu C, Sun Y, Zhang C
Toxicology 2023 Aug 1;494:153587
Toxicology 2023 Aug 1;494:153587
Mechanism of aconitine mediated neuronal apoptosis induced by mitochondrial calcium overload caused by MCU.
Jiang C, Shen J, Wang C, Huang Y, Wang L, Yang Y, Hu W, Li P, Wu H
Toxicology letters 2023 Aug 1;384:86-95
Toxicology letters 2023 Aug 1;384:86-95
Combination with vorinostat enhances the antitumor activity of cisplatin in castration-resistant prostate cancer by inhibiting DNA damage repair pathway and detoxification of GSH.
Chang T, Lian Z, Ma S, Liang Z, Ma X, Wen X, Wang Y, Liu R
The Prostate 2023 Apr;83(5):470-486
The Prostate 2023 Apr;83(5):470-486
RBM3 is associated with acute lung injury in septic mice and patients via the NF-κB/NLRP3 pathway.
Long F, Hu L, Chen Y, Duan X, Xie K, Feng J, Wang M
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Apr;72(4):731-744
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2023 Apr;72(4):731-744
Synergistic activity and mechanism of cytarabine and MCL-1 inhibitor AZD5991 against acute myeloid leukemia.
Wang Y, Wang D, Wang Y, Yang H, Wang G, Wu S
Neoplasma 2023 Apr;70(2):287-293
Neoplasma 2023 Apr;70(2):287-293
NUCKS1 promotes the progression of colorectal cancer via activating PI3K/AKT/mTOR signaling pathway.
Zhu LL, Shi JJ, Guo YD, Yang C, Wang RL, Li SS, Gan DX, Ma PX, Li JQ, Su HC
Neoplasma 2023 Apr;70(2):272-286
Neoplasma 2023 Apr;70(2):272-286
Alpha-ketoglutarate ameliorates induced premature ovarian insufficiency in rats by inhibiting apoptosis and upregulating glycolysis.
Li T, Liu J, Liu K, Wang Q, Cao J, Xiao P, Yang W, Li X, Li J, Li M, Tang X, Li M, Zhang S, Lei X
Reproductive biomedicine online 2023 Apr;46(4):673-685
Reproductive biomedicine online 2023 Apr;46(4):673-685
Hederagenin Suppresses Inflammation and Cartilage Degradation to Ameliorate the Progression of Osteoarthritis: An In vivo and In vitro Study.
Shen Y, Teng L, Qu Y, Huang Y, Peng Y, Tang M, Fu Q
Inflammation 2023 Apr;46(2):655-678
Inflammation 2023 Apr;46(2):655-678
Oridonin ameliorates caspase-9-mediated brain neuronal apoptosis in mouse with ischemic stroke by inhibiting RIPK3-mediated mitophagy.
Li L, Song JJ, Zhang MX, Zhang HW, Zhu HY, Guo W, Pan CL, Liu X, Xu L, Zhang ZY
Acta pharmacologica Sinica 2023 Apr;44(4):726-740
Acta pharmacologica Sinica 2023 Apr;44(4):726-740
Relaxin-2 Prevents Erectile Dysfunction by Cavernous Nerve, Endothelial and Histopathological Protection Effects in Rats with Bilateral Cavernous Nerve Injury.
Liu K, Sun T, Xu W, Song J, Chen Y, Ruan Y, Li H, Cui K, Zhang Y, Feng Y, Pan J, Liang E, Xin Z, Wang T, Wang S, Liu J, Luan Y
The world journal of men's health 2023 Apr;41(2):434-445
The world journal of men's health 2023 Apr;41(2):434-445
Decreased autophagic activity of detrusor cells is involved in the inflammatory response of interstitial cystitis/bladder pain syndrome.
Zhao J, Lu Q, Yang Z, Sun B, Zhu J, Zhang H, Yang C, Yi S, Dong X
International urogynecology journal 2023 Apr;34(4):843-851
International urogynecology journal 2023 Apr;34(4):843-851
Parecoxib attenuates inflammation injury in septic H9c2 cells by regulating the MAPK signaling pathway.
Qian X, Xiong S, Chen Q, Zhang J, Xie J
Experimental and therapeutic medicine 2023 Apr;25(4):150
Experimental and therapeutic medicine 2023 Apr;25(4):150
A prospective diagnostic and prognostic biomarker for hepatocellular carcinoma that functions in glucose metabolism regulation: Solute carrier family 37 member 3.
Meng Z, Geng X, Lin X, Wang Z, Chen D, Liang H, Zhu Y, Sui Y
Biochimica et biophysica acta. Molecular basis of disease 2023 Apr;1869(4):166661
Biochimica et biophysica acta. Molecular basis of disease 2023 Apr;1869(4):166661
Roles of TRPV4 in Regulating Circulating Angiogenic Cells to Promote Coronary Microvascular Regeneration.
Yang W, Wang H, Guo Q, Xu X, Guo T, Sun L
Journal of cardiovascular translational research 2023 Apr;16(2):414-426
Journal of cardiovascular translational research 2023 Apr;16(2):414-426
Dual-specificity phosphatase 26-dificient neurons are susceptible to oxygen-glucose deprivation/reoxygenation-evoked apoptosis and proinflammatory response by affecting the TAK1-medaited JNK/P38 MAPK pathway.
Zhao H, Lv J, Meng L, Lv J, Li Z
International immunopharmacology 2023 Apr;117:109980
International immunopharmacology 2023 Apr;117:109980
Circular RNA circ0104103 inhibits colorectal cancer progression through interactions with HuR and miR-373-5p.
Tan P, Sun H, Xu M, Liu X, Qin J, Nie J, Qin X, Wang S, Pan Y
Cancer science 2023 Apr;114(4):1396-1409
Cancer science 2023 Apr;114(4):1396-1409
Exercise-activated hepatic autophagy via the FN1-α5β1 integrin pathway drives metabolic benefits of exercise.
Kuramoto K, Liang H, Hong JH, He C
Cell metabolism 2023 Apr 4;35(4):620-632.e5
Cell metabolism 2023 Apr 4;35(4):620-632.e5
Diosgenin Inhibits ROS Generation by Modulating NOX4 and Mitochondrial Respiratory Chain and Suppresses Apoptosis in Diabetic Nephropathy.
Zhong Y, Wang L, Jin R, Liu J, Luo R, Zhang Y, Zhu L, Peng X
Nutrients 2023 Apr 30;15(9)
Nutrients 2023 Apr 30;15(9)
NCAPG is transcriptionally regulated by CBX3 and activates the Wnt/β-catenin signaling pathway to promote proliferation and the cell cycle and inhibit apoptosis in colorectal cancer.
Yang H, Pu L, Li R, Zhu R
Journal of gastrointestinal oncology 2023 Apr 29;14(2):900-912
Journal of gastrointestinal oncology 2023 Apr 29;14(2):900-912
Dual role of PID1 in regulating apoptosis induced by distinct anticancer-agents through AKT/Raf-1-dependent pathway in hepatocellular carcinoma.
Yang J, Li S, He J, Xu Q, Xie M, Yang C, Wang H, Zhang Y, Wan Q, Xiang M
Cell death discovery 2023 Apr 28;9(1):139
Cell death discovery 2023 Apr 28;9(1):139
Acinous cell AR42J-derived exosome miR125b-5p promotes acute pancreatitis exacerbation by inhibiting M2 macrophage polarization via PI3K/AKT signaling pathway.
Zheng Z, Cao F, Ding YX, Lu JD, Fu YQ, Liu L, Guo YL, Liu S, Sun HC, Cui YQ, Li F
World journal of gastrointestinal surgery 2023 Apr 27;15(4):600-620
World journal of gastrointestinal surgery 2023 Apr 27;15(4):600-620
An herbal formulation "Shenshuaifu Granule" alleviates cisplatin-induced nephrotoxicity by suppressing inflammation and apoptosis through inhibition of the TLR4/MyD88/NF-κB pathway.
Jin X, He R, Liu J, Wang Y, Li Z, Jiang B, Lu J, Yang S
Journal of ethnopharmacology 2023 Apr 24;306:116168
Journal of ethnopharmacology 2023 Apr 24;306:116168
Administration of prosaposin-derived neurotrophic factor to neural tube defects facilitates regeneration and restores neurological functions.
Khan S, Takeuchi A, Nabeka H, Khan F, Shimokawa T, Takanezawa S, Saitou T, Imamura T, Tachibana T, Nishizono A, Hamada F, Matsuda S
iScience 2023 Apr 21;26(4):106277
iScience 2023 Apr 21;26(4):106277
Melatonin induces cell cycle arrest and suppresses tumor invasion in urinary bladder urothelial carcinoma.
Hsieh TY, Sung WW, Chang YC, Yu CY, Lu LY, Dong C, Lee TH, Chen SL
Aging 2023 Apr 21;15(8):3107-3119
Aging 2023 Apr 21;15(8):3107-3119
[Overexpression of miR-431-5p impairs mitochondrial function and induces apoptosis in gastric cancer cells via the Bax/Bcl-2/caspase3 pathway].
Wu J, Deng Z, Zhu Y, Dou G, Li J, Huang L
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2023 Apr 20;43(4):537-543
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2023 Apr 20;43(4):537-543
Antioxidant, Immunostimulatory, and Anticancer Properties of Hydrolyzed Wheat Bran Mediated through Macrophages Stimulation.
Tomé-Sánchez I, Martínez-Villaluenga C, Martín-Diana AB, Rico D, Jiménez-Pulido I, Frias J, Dia VP
International journal of molecular sciences 2023 Apr 18;24(8)
International journal of molecular sciences 2023 Apr 18;24(8)
Disruption of the Intestinal Mucosal Barrier Induced by High Fructose and Restraint Stress Is Regulated by the Intestinal Microbiota and Microbiota Metabolites.
Yu J, Liu T, Guo Q, Wang Z, Chen Y, Dong Y
Microbiology spectrum 2023 Apr 13;11(2):e0469822
Microbiology spectrum 2023 Apr 13;11(2):e0469822
OBHS Drives Abnormal Glycometabolis Reprogramming via GLUT1 in Breast Cancer.
Wang K, Li Q, Fan Y, Fang P, Zhou H, Huang J
International journal of molecular sciences 2023 Apr 12;24(8)
International journal of molecular sciences 2023 Apr 12;24(8)
Sulforaphane suppresses paraquat-induced oxidative damage in bovine in vitro-matured oocytes through Nrf2 transduction pathway.
Feng Z, Wang T, Sun Y, Chen S, Hao H, Du W, Zou H, Yu D, Zhu H, Pang Y
Ecotoxicology and environmental safety 2023 Apr 1;254:114747
Ecotoxicology and environmental safety 2023 Apr 1;254:114747
Renal Ischemia-reperfusion Injury Attenuated by Exosomes Extracted From Splenic Ischemic Preconditioning Models.
Liu H, Shen Y
Transplantation 2023 Apr 1;107(4):e90-e97
Transplantation 2023 Apr 1;107(4):e90-e97
Aerobic Exercise Training Improves Renal Injury in Spontaneously Hypertensive Rats by Increasing Renalase Expression in Medulla.
Luo M, Cao S, Lv D, He L, He Z, Li L, Li Y, Luo S, Chang Q
Frontiers in cardiovascular medicine 2022;9:922705
Frontiers in cardiovascular medicine 2022;9:922705
Effect of Two Different Drug-Resistant Staphylococcus aureus Strains on the Physiological Properties of MAC-T Cells and Their Transcriptome Analysis.
Yan L, Yang Y, Ma X, Wei L, Wan X, Zhang Z, Ding J, Peng J, Liu G, Gou H, Wang C, Zhang X
Frontiers in veterinary science 2022;9:818928
Frontiers in veterinary science 2022;9:818928
Integrated Strategies of Diverse Feature Selection Methods Identify Aging-Based Reliable Gene Signatures for Ischemic Cardiomyopathy.
Song H, Chen S, Zhang T, Huang X, Zhang Q, Li C, Chen C, Chen S, Liu D, Wang J, Tu Y, Wu Y, Liu Y
Frontiers in molecular biosciences 2022;9:805235
Frontiers in molecular biosciences 2022;9:805235
1,4-dihydroxy quininib modulates the secretome of uveal melanoma tumour explants and a marker of oxidative phosphorylation in a metastatic xenograft model.
Slater K, Bosch R, Smith KF, Jahangir CA, Garcia-Mulero S, Rahman A, O'Connell F, Piulats JM, O'Neill V, Horgan N, Coupland SE, O'Sullivan J, Gallagher WM, Villanueva A, Kennedy BN
Frontiers in medicine 2022;9:1036322
Frontiers in medicine 2022;9:1036322
TRIM47 promotes ovarian cancer cell proliferation, migration, and invasion by activating STAT3 signaling.
Wang X, Fu Y, Xing Y
Clinics (Sao Paulo, Brazil) 2022;77:100122
Clinics (Sao Paulo, Brazil) 2022;77:100122
Antitumor Effects of Astaxanthin on Esophageal Squamous Cell Carcinoma by up-Regulation of PPARγ.
Cui L, Li Z, Xu F, Tian Y, Chen T, Li J, Guo Y, Lyu Q
Nutrition and cancer 2022;74(4):1399-1410
Nutrition and cancer 2022;74(4):1399-1410
MiR-7015-3p Targets Nuclear Factor-Kappa-B-Inhibitor Alpha to Aggravate Hypoxia/Reoxygenation Injury in Cardiomyocytes Through the NF-κB Pathway.
Shen X, Tao J, Wang Z, Li G, Zhang Z, Li J, Diliar A
International heart journal 2022;63(5):881-892
International heart journal 2022;63(5):881-892
Effect of one-time high load exercise on skeletal muscle injury in rats of different genders: oxidative stress and mitochondrial responses.
Wang Y, Chen M, Gao Y, He K, Yang Z, Li Y, Zhang S, Zhao L
Acta cirurgica brasileira 2022;37(8):e370805
Acta cirurgica brasileira 2022;37(8):e370805
Jatrorrhizine reduces myocardial infarction-induced apoptosis and fibrosis through inhibiting p53 and TGF-β1/Smad2/3 pathways in mice.
Hao M, Jiao K
Acta cirurgica brasileira 2022;37(7):e370705
Acta cirurgica brasileira 2022;37(7):e370705
Guanxinping Tablets Inhibit ET-1-Induced Proliferation and Migration of MOVAS by Suppressing Activated PI3K/Akt/NF-κB Signaling Cascade.
Wu YY, Huang YL, Dai B, Liu JW, Han X
Evidence-based complementary and alternative medicine : eCAM 2022;2022:9485463
Evidence-based complementary and alternative medicine : eCAM 2022;2022:9485463
A Network Pharmacology Approach for Uncovering the Antitumor Effects and Potential Mechanisms of the Sijunzi Decoction for the Treatment of Gastric Cancer.
Ding P, Guo Y, Wang C, Chen J, Guo C, Liu H, Shi Q
Evidence-based complementary and alternative medicine : eCAM 2022;2022:9364313
Evidence-based complementary and alternative medicine : eCAM 2022;2022:9364313
Study on the Anti-demyelination Mechanism of Bu-Shen-Yi-Sui Capsule in the Central Nervous System Based on Network Pharmacology and Experimental Verification.
Zha Z, Liu YJ, Liu SS, Zhang N, Li JL, Qi F, Jin LY, Xue B, Yang T, Fan YP, Zhao H, Wang L
Mediators of inflammation 2022;2022:9241261
Mediators of inflammation 2022;2022:9241261
PHGDH Inhibitor CBR-5884 Inhibits Epithelial Ovarian Cancer Progression via ROS/Wnt/β-Catenin Pathway and Plays a Synergistic Role with PARP Inhibitor Olaparib.
Zhang X, Sun M, Jiao Y, Lin B, Yang Q
Oxidative medicine and cellular longevity 2022;2022:9029544
Oxidative medicine and cellular longevity 2022;2022:9029544
Development of a Costimulatory Molecule Signature to Predict Prognosis, Immune Landscape, and Response to Immune Therapy for Hepatocellular Carcinoma.
Zhou Y, Zhou X, Liu Q, Zhang Z, Zhang W, Ma J, Yang M, Yu J, Luo J, Yan Z
Disease markers 2022;2022:8973721
Disease markers 2022;2022:8973721
Loureirin A Exerts Antikeloid Activity by Antagonizing the TGF-β1/Smad Signalling Pathway.
Ma H, Duan X, Zhang R, Li H, Guo Y, Tian Y, Huang M, Chen G, Wang Z, Li L
Evidence-based complementary and alternative medicine : eCAM 2022;2022:8661288
Evidence-based complementary and alternative medicine : eCAM 2022;2022:8661288
Pretreatment with Shenmai Injection Protects against Coronary Microvascular Dysfunction.
Zheng Z, Yu Z, Xu B, Zhou Y, Xing Y, Li Q, Tang W, Peng F
Evidence-based complementary and alternative medicine : eCAM 2022;2022:8630480
Evidence-based complementary and alternative medicine : eCAM 2022;2022:8630480
Resveratrol Induces Apoptosis, Suppresses Migration, and Invasion of Cervical Cancer Cells by Inhibiting the Hedgehog Signaling Pathway.
Jiang J, Liu Z, Zhou X, Peng F, Wang Z, Li F, Li M
BioMed research international 2022;2022:8453011
BioMed research international 2022;2022:8453011
Protective Effect of Phloretin against Hydrogen Peroxide-Induced Oxidative Damage by Enhancing Autophagic Flux in DF-1 Cells.
Song D, Liu F, Tao W, Wu X, Bi H, Li X, Shu J, Wang D
Oxidative medicine and cellular longevity 2022;2022:8359118
Oxidative medicine and cellular longevity 2022;2022:8359118
Keratin 8 Is an Inflammation-Induced and Prognosis-Related Marker for Pancreatic Adenocarcinoma.
Xiong F, Guo T, Wang X, Wu G, Liu W, Wang Q, Wang B, Chen Y
Disease markers 2022;2022:8159537
Disease markers 2022;2022:8159537
EGCG Enhances the Chemosensitivity of Colorectal Cancer to Irinotecan through GRP78-MediatedEndoplasmic Reticulum Stress.
Wu W, Gou H, Xiang B, Geng R, Dong J, Yang X, Chen D, Dai R, Chen L, Liu J
Journal of oncology 2022;2022:7099589
Journal of oncology 2022;2022:7099589
Resveratrol Downregulates miR-155-5p to Block the Malignant Behavior of Gastric Cancer Cells.
Su N, Li L, Zhou E, Li H, Wu S, Cao Z
BioMed research international 2022;2022:6968641
BioMed research international 2022;2022:6968641
Correlation Analysis of Umbilical Cord Blood Metabolic Phenotype and Inflammation in Patients with Gestational Diabetes Mellitus Complicated with Overweight and Obesity.
Chen Q, Li W, Deng Y, Li Y, Huang L, Zhao L, Li H
Evidence-based complementary and alternative medicine : eCAM 2022;2022:6072286
Evidence-based complementary and alternative medicine : eCAM 2022;2022:6072286
Metformin Exhibits an Attractive Antineoplastic Effect on Human Endometrial Cancer by Regulating the Hippo Signaling Pathway.
Wang M, Zhang Q, Li Y, Jin L, Fang Z
Journal of oncology 2022;2022:5824617
Journal of oncology 2022;2022:5824617
Schisandrin B Diet Inhibits Oxidative Stress to Reduce Ferroptosis and Lipid Peroxidation to Prevent Pirarubicin-Induced Hepatotoxicity.
Shi H, Yan Y, Yang H, Pu P, Tang H
BioMed research international 2022;2022:5623555
BioMed research international 2022;2022:5623555
LARS2 Regulates Apoptosis via ROS-Mediated Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in Ovarian Granulosa Cells.
Feng S, Wan S, Liu S, Wang W, Tang M, Bai L, Zhu Y
Oxidative medicine and cellular longevity 2022;2022:5501346
Oxidative medicine and cellular longevity 2022;2022:5501346
The Effects of Hedgehog Signaling Pathway on the Proliferation and Apoptosis of Melanoma Cells.
Peng ZP, Huang SF, Li JJ, Tang XK, Wang XY, Li HM
Journal of oncology 2022;2022:4984866
Journal of oncology 2022;2022:4984866
Evodiamine as the Active Compound of Evodiae fructus to Inhibit Proliferation and Migration of Prostate Cancer through PI3K/AKT/NF-κB Signaling Pathway.
Lei Y, Chan M, Liu H, Lyu W, Chen L, Zhong Y, Gan H, Wang M, Qi M, Guo Y, Liu J, Zhang E
Disease markers 2022;2022:4399334
Disease markers 2022;2022:4399334
The lncRNA KIF9-AS1 Accelerates Hepatocellular Carcinoma Growth by Recruiting DNMT1 to Promote RAI2 DNA Methylation.
Yu Y, Lu X, Yan Y, Wang Y, Meng J, Tian S, Mu J
Journal of oncology 2022;2022:3888798
Journal of oncology 2022;2022:3888798
Prognostic Lnc-S100B-2 Affects Cell Apoptosis and Microenvironment of Colorectal Cancer through MLLT10 Signaling.
Yi J, Peng F, Zhao J, Gong X
Journal of oncology 2022;2022:3565118
Journal of oncology 2022;2022:3565118
p16(INK4a) Plays Critical Role in Exacerbating Inflammaging in High Fat Diet Induced Skin.
Liang Y, Gu T, Peng S, Lin Y, Liu J, Wang X, Huang X, Zhang X, Zhu J, Zhao L, Fan C, Wang G, Gu X, Lin J
Oxidative medicine and cellular longevity 2022;2022:3415528
Oxidative medicine and cellular longevity 2022;2022:3415528
Hax-1 Regulates Radiation-Induced Mitochondrial-Dependent Apoptosis of Uveal Melanoma Cells through PI3K/AKT/eNOS Pathway.
Wang S, Tan J, Chen L, Wang J
Journal of oncology 2022;2022:2956888
Journal of oncology 2022;2022:2956888
Mechanism Study of Cinnamomi Ramulus and Paris polyphylla Sm. Drug Pair in the Treatment of Adenomyosis by Network Pharmacology and Experimental Validation.
Zhang K, Zhou Z, Wang C, Yu M, Zhang Y, Shi Y, Wang X, Liu Y, Xu L, Shi W, Liu Z
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2624434
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2624434
Grape Seed Proanthocyanidins Exert a Neuroprotective Effect by Regulating Microglial M1/M2 Polarisation in Rats with Spinal Cord Injury.
Liu WZ, Ma ZJ, Kang JH, Lin AX, Wang ZH, Chen HW, Guo XD, He XG, Kang XW
Mediators of inflammation 2022;2022:2579003
Mediators of inflammation 2022;2022:2579003
DJ-1/FGFR-1 Signaling Pathway Contributes to Sorafenib Resistance in Hepatocellular Carcinoma.
Chen X, Yang G, Guo X, Zhang J, Sun W, Liu D, Wang H, Liu S
Oxidative medicine and cellular longevity 2022;2022:2543220
Oxidative medicine and cellular longevity 2022;2022:2543220
Oleoylethanolamide Alleviates Hepatic Ischemia-Reperfusion Injury via Inhibiting Endoplasmic Reticulum Stress-Associated Apoptosis.
Qi S, Yan Q, Wang Z, Liu D, Zhan M, Du J, Chen L
PPAR research 2022;2022:2212996
PPAR research 2022;2022:2212996
Sestrin2 Overexpression Ameliorates Endoplasmic Reticulum Stress-Induced Apoptosis via Inhibiting mTOR Pathway in HepG2 Cells.
Hu H, Luo Z, Liu X, Huang L, Lu X, Ding R, Duan C, He Y
International journal of endocrinology 2022;2022:2009753
International journal of endocrinology 2022;2022:2009753
Overexpression of Aquaporin-3 Alleviates Hyperosmolarity-Induced Nucleus Pulposus Cell Apoptosis via Regulating the ERK1/2 Pathway.
Zhang Z, Zhao C, Zhang R, Wang Y, Hu Y, Zhou Q, Li P
Pain research & management 2022;2022:1639560
Pain research & management 2022;2022:1639560
PCNP is a novel regulator of proliferation, migration, and invasion in human thyroid cancer.
Chen YG, Liu HX, Hong Y, Dong PZ, Liu SY, Gao YR, Lu D, Li T, Wang DY, Wu DD, Ji XY
International journal of biological sciences 2022;18(9):3605-3620
International journal of biological sciences 2022;18(9):3605-3620
A marine-derived small molecule induces immunogenic cell death against triple-negative breast cancer through ER stress-CHOP pathway.
Wen H, Zhong Y, Yin Y, Qin K, Yang L, Li D, Yu W, Yang C, Deng Z, Hong K
International journal of biological sciences 2022;18(7):2898-2913
International journal of biological sciences 2022;18(7):2898-2913
Yap is essential for uterine decidualization through Rrm2/GSH/ROS pathway in response to Bmp2.
Yu HF, Yang ZQ, Xu MY, Huang JC, Yue ZP, Guo B
International journal of biological sciences 2022;18(6):2261-2276
International journal of biological sciences 2022;18(6):2261-2276
HJURP Promotes Malignant Progression and Mediates Sensitivity to Cisplatin and WEE1-inhibitor in Serous Ovarian Cancer.
Dou Z, Qiu C, Zhang X, Yao S, Zhao C, Wang Z, Chu R, Chen J, Chen Z, Li R, Wang K, Liu P, Liu C, Song K, Kong B
International journal of biological sciences 2022;18(3):1188-1210
International journal of biological sciences 2022;18(3):1188-1210
Dezocine inhibits cell proliferation, migration, and invasion by targeting CRABP2 in ovarian cancer.
Zhang C, Pan R, Ma S, Xu S, Wang B
Open medicine (Warsaw, Poland) 2022;17(1):2052-2061
Open medicine (Warsaw, Poland) 2022;17(1):2052-2061
Ketamine Attenuates Airway Inflammation via Inducing Inflammatory Cells Apoptosis and Activating Nrf2 Pathway in a Mixed-Granulocytic Murine Asthma Model.
Xiao S, Zhou Y, Wang Q, Yang D
Drug design, development and therapy 2022;16:4411-4428
Drug design, development and therapy 2022;16:4411-4428
Keloid Patient Plasma-Derived Exosomal hsa_circ_0020792 Promotes Normal Skin Fibroblasts Proliferation, Migration, and Fibrogenesis via Modulating miR-193a-5p and Activating TGF-β1/Smad2/3 Signaling.
Hu H, Mao G, Zheng J, Guo F
Drug design, development and therapy 2022;16:4223-4234
Drug design, development and therapy 2022;16:4223-4234
Feasibility of Catalpol Intranasal Administration and Its Protective Effect on Acute Cerebral Ischemia in Rats via Anti-Oxidative and Anti-Apoptotic Mechanisms.
Wang J, Zhang Y, Zhang M, Sun S, Zhong Y, Han L, Xu Y, Wan D, Zhang J, Zhu H
Drug design, development and therapy 2022;16:279-296
Drug design, development and therapy 2022;16:279-296
Magnesium Lithospermate B Protects Against Cisplatin-Induced Acute Kidney Injury via Alleviating Mitochondrial Dysfunction.
Shen D, Guo M, Geng X, Yu J, Zhang Z, Lin J, Lin P, Ding X, Xu X
Drug design, development and therapy 2022;16:2293-2304
Drug design, development and therapy 2022;16:2293-2304
Didymin Ameliorates Liver Fibrosis by Alleviating Endoplasmic Reticulum Stress and Glycerophospholipid Metabolism: Based on Transcriptomics and Metabolomics.
Li Y, Li C, Xiong Y, Fang B, Lin X, Huang Q
Drug design, development and therapy 2022;16:1713-1729
Drug design, development and therapy 2022;16:1713-1729
Shikonin Attenuates Cochlear Spiral Ganglion Neuron Degeneration by Activating Nrf2-ARE Signaling Pathway.
Du H, Zhou X, Shi L, Xia M, Wang Y, Guo N, Hu H, Zhang P, Yang H, Zhu F, Teng Z, Liu C, Zhao M
Frontiers in molecular neuroscience 2022;15:829642
Frontiers in molecular neuroscience 2022;15:829642
Inhibitory effect of taurine on rotator cuff degeneration via mitochondrial protection.
Ueda S, Ichiseki T, Shimasaki M, Hirata H, Kawahara N, Ueda Y
American journal of translational research 2022;14(9):6286-6294
American journal of translational research 2022;14(9):6286-6294
Mannan-Binding Lectin via Interaction With Cell Surface Calreticulin Promotes Senescence of Activated Hepatic Stellate Cells to Limit Liver Fibrosis Progression.
Luo J, Li L, Chang B, Zhu Z, Deng F, Hu M, Yu Y, Lu X, Chen Z, Zuo D, Zhou J
Cellular and molecular gastroenterology and hepatology 2022;14(1):75-99
Cellular and molecular gastroenterology and hepatology 2022;14(1):75-99
Exploring the pharmacological mechanisms of icaritin against nasopharyngeal carcinoma via network pharmacology and experimental validation.
Liu M, Hu T, Gou W, Chang H, Li Y, Li Y, Zuo D, Hou W, Jiao S
Frontiers in pharmacology 2022;13:993022
Frontiers in pharmacology 2022;13:993022
NRF2-directed PRPS1 upregulation to promote the progression and metastasis of melanoma.
Xiong G, Feng Y, Yi X, Zhang X, Li X, Yang L, Yi Z, Sai B, Yang Z, Zhang Q, Kuang Y, Zhu Y
Frontiers in immunology 2022;13:989263
Frontiers in immunology 2022;13:989263
Alleviating effect of quercetin on cadmium-induced oxidative damage and apoptosis by activating the Nrf2-keap1 pathway in BRL-3A cells.
Wang J, Wang K, Ding L, Zhao P, Zhang C, Wang H, Yang Z, Liu Z
Frontiers in pharmacology 2022;13:969892
Frontiers in pharmacology 2022;13:969892
The miR-33a-5p/CROT axis mediates ovarian cancer cell behaviors and chemoresistance via the regulation of the TGF-β signal pathway.
Li X, Gao X, Yuan J, Wang F, Xu X, Wang C, Liu H, Guan W, Zhang J, Xu G
Frontiers in endocrinology 2022;13:950345
Frontiers in endocrinology 2022;13:950345
D-tagatose protects against oleic acid-induced acute respiratory distress syndrome in rats by activating PTEN/PI3K/AKT pathway.
Huang J, Wang B, Tao S, Hu Y, Wang N, Zhang Q, Wang C, Chen C, Gao B, Cheng X, Li Y
Frontiers in immunology 2022;13:928312
Frontiers in immunology 2022;13:928312
Acetyl-11-Keto-Beta Boswellic Acid (AKBA) Protects Lens Epithelial Cells Against H(2)O(2)-Induced Oxidative Injury and Attenuates Cataract Progression by Activating Keap1/Nrf2/HO-1 Signaling.
Yang T, Lin X, Li H, Zhou X, Fan F, Yang J, Luo Y, Liu X
Frontiers in pharmacology 2022;13:927871
Frontiers in pharmacology 2022;13:927871
Furfural Produces Dose-Dependent Attenuating Effects on Ethanol-Induced Toxicity in the Liver.
Cheng Z, Luo X, Zhu Z, Huang Y, Yan X
Frontiers in pharmacology 2022;13:906933
Frontiers in pharmacology 2022;13:906933
ABCA12 Promotes Proliferation and Migration and Inhibits Apoptosis of Pancreatic Cancer Cells Through the AKT Signaling Pathway.
Zheng S, Liu D, Wang F, Jin Y, Zhao S, Sun S, Wang S
Frontiers in genetics 2022;13:906326
Frontiers in genetics 2022;13:906326
Interleukin-6-derived cancer-associated fibroblasts activate STAT3 pathway contributing to gemcitabine resistance in cholangiocarcinoma.
Kittirat Y, Suksawat M, Thongchot S, Padthaisong S, Phetcharaburanin J, Wangwiwatsin A, Klanrit P, Sangkhamanon S, Titapun A, Loilome W, Saya H, Namwat N
Frontiers in pharmacology 2022;13:897368
Frontiers in pharmacology 2022;13:897368
Autophagy Inhibition Enhances the Anti-Tumor Activity of Methylseleninic Acid in Cisplatin-Resistance Human Lung Adenocarcinoma Cells.
Xin M, Gao Q, Xiang X, Xu J, Jiao Y, Li X, Zhang X, Jia X
Frontiers in pharmacology 2022;13:890974
Frontiers in pharmacology 2022;13:890974
FGF2 Is Protective Towards Cisplatin-Induced KGN Cell Toxicity by Promoting FTO Expression and Autophagy.
Wang R, Wang L, Wang L, Cui Z, Cheng F, Wang W, Yang X
Frontiers in endocrinology 2022;13:890623
Frontiers in endocrinology 2022;13:890623
Engineered Exosomes-Mediated Transfer of hsa-miR-320a Overcomes Chemoresistance in Cervical Cancer Cells via Targeting MCL1.
Zhou J, Wang Y, Zhang L, Chen Q, Zhu X, Jiang P, Jiang N, Zhao W, Li B
Frontiers in pharmacology 2022;13:883445
Frontiers in pharmacology 2022;13:883445
High expression of B4GALT1 is associated with poor prognosis in acute myeloid leukemia.
Ren Z, Huang X, Lv Q, Lei Y, Shi H, Wang F, Wang M
Frontiers in genetics 2022;13:882004
Frontiers in genetics 2022;13:882004
H1N1 Influenza Virus-Infected Nasal Mucosal Epithelial Progenitor Cells Promote Dendritic Cell Recruitment and Maturation.
Zhu F, Teng Z, Zhou X, Xu R, Bing X, Shi L, Guo N, Wang M, Liu C, Xia M
Frontiers in immunology 2022;13:879575
Frontiers in immunology 2022;13:879575
Dimethyl Fumarate Ameliorates Doxorubicin-Induced Cardiotoxicity By Activating the Nrf2 Pathway.
Hu X, Li C, Wang Q, Wei Z, Chen T, Wang Y, Li Y
Frontiers in pharmacology 2022;13:872057
Frontiers in pharmacology 2022;13:872057
Cytosolic p53 Inhibits Parkin-Mediated Mitophagy and Promotes Acute Liver Injury Induced by Heat Stroke.
Huang W, Xie W, Zhong H, Cai S, Huang Q, Liu Y, Zeng Z, Liu Y
Frontiers in immunology 2022;13:859231
Frontiers in immunology 2022;13:859231
Gluconolactone Alleviates Myocardial Ischemia/Reperfusion Injury and Arrhythmias via Activating PKCε/Extracellular Signal-Regulated Kinase Signaling.
Qin X, Liu B, Gao F, Hu Y, Chen Z, Xu J, Zhang X
Frontiers in physiology 2022;13:856699
Frontiers in physiology 2022;13:856699
Silibinin Therapy Improves Cholangiocarcinoma Outcomes by Regulating ERK/Mitochondrial Pathway.
Bai Y, Chen J, Hu W, Wang L, Wu Y, Yu S
Frontiers in pharmacology 2022;13:847905
Frontiers in pharmacology 2022;13:847905
Identification and Validation of Ferroptosis-Related Biomarkers in Septic Cardiomyopathy via Bioinformatics Analysis.
Gong CW, Yuan MM, Qiu BQ, Wang LJ, Zou HX, Hu T, Lai SQ, Liu JC
Frontiers in genetics 2022;13:827559
Frontiers in genetics 2022;13:827559
Tormentic Acid Ameliorates Hepatic Fibrosis in vivo by Inhibiting Glycerophospholipids Metabolism and PI3K/Akt/mTOR and NF-κB Pathways: Based on Transcriptomics and Metabolomics.
Lin X, Wei Y, Li Y, Xiong Y, Fang B, Li C, Huang Q, Huang R, Wei J
Frontiers in pharmacology 2022;13:801982
Frontiers in pharmacology 2022;13:801982
Natural product manoalide promotes EGFR-TKI sensitivity of lung cancer cells by KRAS-ERK pathway and mitochondrial Ca(2+) overload-induced ferroptosis.
Ni Y, Liu J, Zeng L, Yang Y, Liu L, Yao M, Chai L, Zhang L, Li Y, Zhang L, Li W
Frontiers in pharmacology 2022;13:1109822
Frontiers in pharmacology 2022;13:1109822
Corilagin alleviates intestinal ischemia/reperfusion-induced intestinal and lung injury in mice via inhibiting NLRP3 inflammasome activation and pyroptosis.
Li W, Yang K, Li B, Wang Y, Liu J, Chen D, Diao Y
Frontiers in pharmacology 2022;13:1060104
Frontiers in pharmacology 2022;13:1060104
Malvidin alleviates mitochondrial dysfunction and ROS accumulation through activating AMPK-α/UCP2 axis, thereby resisting inflammation and apoptosis in SAE mice.
Zhao P, Li X, Yang Q, Lu Y, Wang G, Yang H, Dong J, Zhang H
Frontiers in pharmacology 2022;13:1038802
Frontiers in pharmacology 2022;13:1038802
Bisphenols A and F, but not S, induce apoptosis in bovine granulosa cells via the intrinsic mitochondrial pathway.
Kourmaeva E, Sabry R, Favetta LA
Frontiers in endocrinology 2022;13:1028438
Frontiers in endocrinology 2022;13:1028438
Ginkgolide C slows the progression of osteoarthritis by activating Nrf2/HO-1 and blocking the NF-κB pathway.
Ma T, Jia L, Zhao J, Lv L, Yu Y, Ruan H, Song X, Chen H, Li X, Zhang J, Gao L
Frontiers in pharmacology 2022;13:1027553
Frontiers in pharmacology 2022;13:1027553
BCATc inhibitor 2 ameliorated mitochondrial dysfunction and apoptosis in oleic acid-induced non-alcoholic fatty liver disease model.
Lu Z, Sun GF, Pan XA, Qu XH, Yang P, Chen ZP, Han XJ, Wang T
Frontiers in pharmacology 2022;13:1025551
Frontiers in pharmacology 2022;13:1025551
Network pharmacology-based and experimental identification of the effects of Renshen Yangrong decoction on myocardial infarction.
Zhao J, Xu X, Yang X
Frontiers in pharmacology 2022;13:1010036
Frontiers in pharmacology 2022;13:1010036
METTL3/m(6)A/IFIT2 regulates proliferation, invasion and immunity in esophageal squamous cell carcinoma.
Ge F, Li Z, Hu J, Pu Y, Zhao F, Kong L
Frontiers in pharmacology 2022;13:1002565
Frontiers in pharmacology 2022;13:1002565
Cordycepin enhances radiosensitivity to induce apoptosis through cell cycle arrest, caspase pathway and ER stress in MA-10 mouse Leydig tumor cells.
Lee YP, Huang WR, Wu WS, Wu YH, Ho SY, Wang YJ, Huang BM
American journal of cancer research 2022;12(8):3601-3624
American journal of cancer research 2022;12(8):3601-3624
INPP4B inhibits glioma cell proliferation and immune escape via inhibition of the PI3K/AKT signaling pathway.
Sun X, Chen Y, Tao X, Zhang W, Wang X, Wang X, Ruan Z, Chen Z
Frontiers in oncology 2022;12:983537
Frontiers in oncology 2022;12:983537
The Novel lncRNA RP9P Promotes Colorectal Cancer Progression by Modulating miR-133a-3p/FOXQ1 Axis.
Jin Z, Liu B, Lin B, Yang R, Wu C, Xue W, Zou X, Qian J
Frontiers in oncology 2022;12:843064
Frontiers in oncology 2022;12:843064
Hinokiflavone Inhibits Growth of Esophageal Squamous Cancer By Inducing Apoptosis via Regulation of the PI3K/AKT/mTOR Signaling Pathway.
Guo J, Zhang S, Wang J, Zhang P, Lu T, Zhang L
Frontiers in oncology 2022;12:833719
Frontiers in oncology 2022;12:833719
Fusobacterium necrophorum Promotes Apoptosis and Inflammatory Cytokine Production Through the Activation of NF-κB and Death Receptor Signaling Pathways.
Wang FF, Zhao PY, He XJ, Jiang K, Wang TS, Xiao JW, Sun DB, Guo DH
Frontiers in cellular and infection microbiology 2022;12:827750
Frontiers in cellular and infection microbiology 2022;12:827750
Prognostic biomarker MCP-4 triggers epithelial-mesenchymal transition via the p38 MAPK pathway in ovarian cancer.
Li S, Hu Y, Liu O, Li X, Lin B
Frontiers in oncology 2022;12:1034737
Frontiers in oncology 2022;12:1034737
Sophocarpine inhibits tumor progression by antagonizing the PI3K/AKT/mTOR signaling pathway in castration-resistant prostate cancer.
Weng M, Shi C, Han H, Zhu H, Xiao Y, Guo H, Yu Z, Wu C
PeerJ 2022;10:e14042
PeerJ 2022;10:e14042
Glucocorticoids induce osteonecrosis of the femoral head in rats via PI3K/AKT/FOXO1 signaling pathway.
Sun F, Zhou JL, Wei SX, Jiang ZW, Peng H
PeerJ 2022;10:e13319
PeerJ 2022;10:e13319
Protection of catalpol against triptolide-induced hepatotoxicity by inhibiting excessive autophagy via the PERK-ATF4-CHOP pathway.
Zhang L, Li C, Fu L, Yu Z, Xu G, Zhou J, Shen M, Feng Z, Zhu H, Xie T, Zhou L, Zhou X
PeerJ 2022;10:e12759
PeerJ 2022;10:e12759
Therapeutic targeting of ARID1A and PI3K/AKT pathway alterations in cholangiocarcinoma.
Tessiri S, Techasen A, Kongpetch S, Namjan A, Loilome W, Chan-On W, Thanan R, Jusakul A
PeerJ 2022;10:e12750
PeerJ 2022;10:e12750
A nanobody-based molecular toolkit for ubiquitin-proteasome system explores the main role of survivin subcellular localization.
Miao H, Liu C, Ouyang H, Zhang P, Liu Y, Zhang C, Deng C, Fu Y, Niu J, Zheng W, You F, Yang Y, Ma X
Frontiers in bioengineering and biotechnology 2022;10:952237
Frontiers in bioengineering and biotechnology 2022;10:952237
Dexamethasone Alleviates Myocardial Injury in a Rat Model of Acute Myocardial Infarction Supported by Venoarterial Extracorporeal Membrane Oxygenation.
Cheng X, Zhang R, Wei S, Huang J, Zhai K, Li Y, Gao B
Frontiers in public health 2022;10:900751
Frontiers in public health 2022;10:900751
The Circular RNA CircCOL1A1 Functions as a miR-149-5p Sponge to Regulate the Formation of Superior-Quality Brush Hair via the CMTM3/AR Axis.
Wang J, Wu X, Sun X, Zhang L, Wang Q, Qu J, Wang Y, Li Y
Frontiers in cell and developmental biology 2022;10:760466
Frontiers in cell and developmental biology 2022;10:760466
TMPRSS12 Functions in Meiosis and Spermiogenesis and Is Required for Male Fertility in Mice.
Zhang J, Zhou X, Wan D, Yu L, Chen X, Yan T, Wu Z, Zheng M, Zhu F, Zhu H
Frontiers in cell and developmental biology 2022;10:757042
Frontiers in cell and developmental biology 2022;10:757042
A bavachinin analog, D36, induces cell death by targeting both autophagy and apoptosis pathway in acute myeloid leukemia cells.
Zhang W, Liu J, Li Y, Guo F
Cancer chemotherapy and pharmacology 2022 Sep;90(3):251-265
Cancer chemotherapy and pharmacology 2022 Sep;90(3):251-265
Effect of thymoquinone on sepsis-induced cardiac damage via anti-inflammatory and anti-apoptotic mechanisms.
Guo W, Long X, Lv M, Deng S, Liu D, Yang Q
The Journal of international medical research 2022 Sep;50(9):3000605221118680
The Journal of international medical research 2022 Sep;50(9):3000605221118680
Ginsenoside Rg3 increases gemcitabine sensitivity of pancreatic adenocarcinoma via reducing ZFP91 mediated TSPYL2 destabilization.
Pan H, Yang L, Bai H, Luo J, Deng Y
Journal of ginseng research 2022 Sep;46(5):636-645
Journal of ginseng research 2022 Sep;46(5):636-645
Protective Effect of Shenfu Injection on Vascular Endothelial Damage in a Porcine Model of Hemorrhagic Shock.
Zhang MQ, Zhang Q, Yuan W, Wu JY, Liang Y, Qin HJ, Li CS
Chinese journal of integrative medicine 2022 Sep;28(9):794-801
Chinese journal of integrative medicine 2022 Sep;28(9):794-801
UFL1 alleviates ER stress and apoptosis stimulated by LPS via blocking the ferroptosis pathway in human granulosa-like cells.
Li J, Tang X, Tu X, Jin Z, Dong H, Yang Q, Yao T, Pan Z
Cell stress & chaperones 2022 Sep;27(5):485-497
Cell stress & chaperones 2022 Sep;27(5):485-497
Suppression of EZH2 inhibits TGF-β1-induced EMT in human retinal pigment epithelial cells.
Peng Y, Liao K, Tan F, Liang Y, Sun X, Cui Z, Ye B, Chen Z, Tang S, Chen J
Experimental eye research 2022 Sep;222:109158
Experimental eye research 2022 Sep;222:109158
Inhibition of 8-oxoguanine DNA glycosylase (OGG1) expression suppresses polycystic ovarian syndrome via the NF-κB signaling pathway.
Xia J, Wu S, Wu G, Yang J
Reproductive biology 2022 Sep;22(3):100679
Reproductive biology 2022 Sep;22(3):100679
Discoidin domain receptor 1(DDR1) promote intestinal barrier disruption in Ulcerative Colitis through tight junction proteins degradation and epithelium apoptosis.
Li X, Li Q, Xiong B, Chen H, Wang X, Zhang D
Pharmacological research 2022 Sep;183:106368
Pharmacological research 2022 Sep;183:106368
Design, semi-synthesis and bioactivity evaluation of novel podophyllotoxin derivatives as potent anti-tumor agents.
Sun W, Sun F, Meng J, Cao X, Zhao S, Wang C, Li L, Jiang P
Bioorganic chemistry 2022 Sep;126:105906
Bioorganic chemistry 2022 Sep;126:105906
N-Acetyl-l-tryptophan inhibits CCl(4)-induced hepatic fibrogenesis via regulating TGF-β1/SMAD and Hippo/YAP1 signal.
Ma T, Cheng H, Li T, Chen Y, Cai T, Bai J, Wu Z, Xia X, Liang T, Du Y, Fu W
Bioorganic chemistry 2022 Sep;126:105899
Bioorganic chemistry 2022 Sep;126:105899
MiR-1306-5p promotes cell proliferation and inhibits cell apoptosis in acute myeloid leukemia by downregulating PHF6 expression.
Gao X, Fan S, Zhang X
Leukemia research 2022 Sep;120:106906
Leukemia research 2022 Sep;120:106906
Chlorogenic acid suppresses miR-460a in the regulation of Bcl-2, causing interleukin-1β reduction in thiram exposed chondrocytes via caspase-3/caspase-7 pathway.
Kulyar MF, Mo Q, Yao W, Ding Y, Yan Z, Du H, Pan H, Li K, Gao J, Shahzad M, Mansoor MK, Iqbal M, Waqas M, Akhtar M, Bhutta ZA, Li J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154296
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154296
GTSE1 promotes tumor growth and metastasis by attenuating of KLF4 expression in clear cell renal cell carcinoma.
Chen W, Wang H, Lu Y, Huang Y, Xuan Y, Li X, Guo T, Wang C, Lai D, Wu S, Zhao W, Mai H, Li H, Wang B, Ma X, Zhang X
Laboratory investigation; a journal of technical methods and pathology 2022 Sep;102(9):1011-1022
Laboratory investigation; a journal of technical methods and pathology 2022 Sep;102(9):1011-1022
TRIM36 inhibits tumorigenesis through the Wnt/β-catenin pathway and promotes caspase-dependent apoptosis in hepatocellular carcinoma.
Tong Q, Yi M, Kong P, Xu L, Huang W, Niu Y, Gan X, Zhan H, Tian R, Yan D
Cancer cell international 2022 Sep 6;22(1):278
Cancer cell international 2022 Sep 6;22(1):278
METTL3 suppresses anlotinib sensitivity by regulating m(6)A modification of FGFR3 in oral squamous cell carcinoma.
Chen J, Li S, Huang Z, Cao C, Wang A, He Q
Cancer cell international 2022 Sep 27;22(1):295
Cancer cell international 2022 Sep 27;22(1):295
HOXA5 inhibits the proliferation of extrahepatic cholangiocarcinoma cells by enhancing MXD1 expression and activating the p53 pathway.
Xiong F, Liu W, Wang X, Wu G, Wang Q, Guo T, Huang W, Wang B, Chen Y
Cell death & disease 2022 Sep 27;13(9):829
Cell death & disease 2022 Sep 27;13(9):829
Small extracellular vesicles of hypoxic endothelial cells regulate the therapeutic potential of adipose-derived mesenchymal stem cells via miR-486-5p/PTEN in a limb ischemia model.
Shen Z, Wang W, Chen J, Chen B, Tang Y, Hou J, Li J, Liu S, Mei Y, Zhang L, Lu S
Journal of nanobiotechnology 2022 Sep 24;20(1):422
Journal of nanobiotechnology 2022 Sep 24;20(1):422
Taraxasterol Inhibits Tumor Growth by Inducing Apoptosis and Modulating the Tumor Microenvironment in Non-Small Cell Lung Cancer.
Lu J, Shuai B, Shou Z, Guo W, Zhou C, Ouyang X, Zhou H, Li J, Cui J, Jiang F, Jin KY, Sarapultsev A, Li F, Zhang G, Luo S, Hu D
Cancers 2022 Sep 24;14(19)
Cancers 2022 Sep 24;14(19)
Co-Targeting ErbB Receptors and the PI3K/AKT Axis in Androgen-Independent Taxane-Sensitive and Taxane-Resistant Human Prostate Cancer Cells.
Adediran S, Wang L, Khan MA, Guang W, Fan X, Dan H, Qi J, Jay SM, Carrier F, Hussain A
Cancers 2022 Sep 23;14(19)
Cancers 2022 Sep 23;14(19)
Daidzein alleviates doxorubicin-induced heart failure via the SIRT3/FOXO3a signaling pathway.
Li H, Zhang M, Wang Y, Gong K, Yan T, Wang D, Meng X, Yang X, Chen Y, Han J, Duan Y, Zhang S
Food & function 2022 Sep 22;13(18):9576-9588
Food & function 2022 Sep 22;13(18):9576-9588
Isoalantolactone (IAL) Regulates Neuro-Inflammation and Neuronal Apoptosis to Curb Pathology of Parkinson's Disease.
He D, Liu Y, Li J, Wang H, Ye B, He Y, Li Z, Gao X, Fu S, Liu D
Cells 2022 Sep 19;11(18)
Cells 2022 Sep 19;11(18)
Zearalenone Promotes LPS-Induced Oxidative Stress, Endoplasmic Reticulum Stress, and Accelerates Bovine Mammary Epithelial Cell Apoptosis.
Fu Y, Jin Y, Tian Y, Yu H, Wang R, Qi H, Feng B, Zhang J
International journal of molecular sciences 2022 Sep 18;23(18)
International journal of molecular sciences 2022 Sep 18;23(18)
Chronic acrylamide exposure resulted in dopaminergic neuron loss, neuroinflammation and motor impairment in rats.
Liu Y, Wang Y, Zhang X, Jiao Y, Duan L, Dai L, Yan H
Toxicology and applied pharmacology 2022 Sep 15;451:116190
Toxicology and applied pharmacology 2022 Sep 15;451:116190
Neuropeptide-Functionalized Gold Nanorod Enhanced Cellular Uptake and Improved In Vitro Photothermal Killing in LRP1-Positive Glioma Cells.
Sivasoorian SS, Urade R, Chiu CC, Wang LF
Pharmaceutics 2022 Sep 13;14(9)
Pharmaceutics 2022 Sep 13;14(9)
Comprehensive comparison between azacytidine and decitabine treatment in an acute myeloid leukemia cell line.
Aumer T, Gremmelmaier CB, Runtsch LS, Pforr JC, Yeşiltaç GN, Kaiser S, Traube FR
Clinical epigenetics 2022 Sep 11;14(1):113
Clinical epigenetics 2022 Sep 11;14(1):113
1-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)-3-(2-(dimethylamino)ethyl)imidazolidin-2-one (ZX-42) inhibits cell proliferation and induces apoptosis via inhibiting ALK and its downstream pathways in Karpas299 cells.
Chang X, Wang J, Bian J, Liu Z, Guo M, Li Z, Wu Y, Zhai X, Zuo D
Toxicology and applied pharmacology 2022 Sep 1;450:116156
Toxicology and applied pharmacology 2022 Sep 1;450:116156
LIS1 interacts with CLIP170 to promote tumor growth and metastasis via the Cdc42 signaling pathway in salivary gland adenoid cystic carcinoma.
Li L, Wen Z, Kou N, Liu J, Jin D, Wang L, Wang F, Gao L
International journal of oncology 2022 Oct;61(4)
International journal of oncology 2022 Oct;61(4)
Hace1 overexpression mitigates myocardial hypoxia/reoxygenation injury via the effects on Keap1/Nrf2 pathway.
Chen TY, Zheng SK
In vitro cellular & developmental biology. Animal 2022 Oct;58(9):830-839
In vitro cellular & developmental biology. Animal 2022 Oct;58(9):830-839
TMBIM6 promotes diabetic tubular epithelial cell survival and albumin endocytosis by inhibiting the endoplasmic reticulum stress sensor, IRE1α.
Xie H, Shi Y, Zhou Y, Liu H
Molecular biology reports 2022 Oct;49(10):9181-9194
Molecular biology reports 2022 Oct;49(10):9181-9194
PLEK2 promotes cancer stemness and tumorigenesis of head and neck squamous cell carcinoma via the c-Myc-mediated positive feedback loop.
Zhao X, Shu D, Sun W, Si S, Ran W, Guo B, Cui L
Cancer communications (London, England) 2022 Oct;42(10):987-1007
Cancer communications (London, England) 2022 Oct;42(10):987-1007
Bortezomib prodrug catalytic nanoreactor for chemo/chemodynamic therapy and macrophage re-education.
Huang Y, Guan Z, Ren L, Luo Y, Chen M, Sun Y, He Y, Zeng Z, Dai X, Jiang J, Huang Z, Zhao C
Journal of controlled release : official journal of the Controlled Release Society 2022 Oct;350:332-349
Journal of controlled release : official journal of the Controlled Release Society 2022 Oct;350:332-349
Transcription factor YY1 contributes to human melanoma cell growth through modulating the p53 signalling pathway.
Zhou S, Li P, Qin L, Huang S, Dang N
Experimental dermatology 2022 Oct;31(10):1563-1578
Experimental dermatology 2022 Oct;31(10):1563-1578
Mechanical stretch aggravates vascular smooth muscle cell apoptosis and vascular remodeling by downregulating EZH2.
Zhong HY, Yuan C, Liu XL, Wang QQ, Li X, Zhao YC, Li X, Liu DD, Zheng TF, Zhang M
The international journal of biochemistry & cell biology 2022 Oct;151:106278
The international journal of biochemistry & cell biology 2022 Oct;151:106278
Aucubin promoted neuron functional recovery by suppressing inflammation and neuronal apoptosis in a spinal cord injury model.
Xiao S, Zhong N, Yang Q, Li A, Tong W, Zhang Y, Yao G, Wang S, Liu J, Liu Z
International immunopharmacology 2022 Oct;111:109163
International immunopharmacology 2022 Oct;111:109163
Chicoric acid attenuates tumor necrosis factor-α-induced inflammation and apoptosis via the Nrf2/HO-1, PI3K/AKT and NF-κB signaling pathways in C28/I2 cells and ameliorates the progression of osteoarthritis in a rat model.
Qu Y, Shen Y, Teng L, Huang Y, Yang Y, Jian X, Fan S, Wu P, Fu Q
International immunopharmacology 2022 Oct;111:109129
International immunopharmacology 2022 Oct;111:109129
Exosomes Derived from Bone Marrow Mesenchymal Stem Cells Alleviate Ischemia-Reperfusion Injury and Promote Survival of Skin Flaps in Rats.
Niu Q, Yang Y, Li D, Guo W, Wang C, Xu H, Feng Z, Han Z
Life (Basel, Switzerland) 2022 Oct 9;12(10)
Life (Basel, Switzerland) 2022 Oct 9;12(10)
UBXD8 mediates mitochondria-associated degradation to restrain apoptosis and mitophagy.
Zheng J, Cao Y, Yang J, Jiang H
EMBO reports 2022 Oct 6;23(10):e54859
EMBO reports 2022 Oct 6;23(10):e54859
Regulation of Proliferation and Apoptosis of Hair Follicle Stem Cells by miR-145-5p in Yangtze River Delta White Goats.
Wu X, Wang J, Kang Y, Wang Q, Qu J, Sun X, Ji D, Li Y
Genes 2022 Oct 28;13(11)
Genes 2022 Oct 28;13(11)
DNMT3A R882H mutation drives daunorubicin resistance in acute myeloid leukemia via regulating NRF2/NQO1 pathway.
Chu X, Zhong L, Dan W, Wang X, Zhang Z, Liu Z, Lu Y, Shao X, Zhou Z, Chen S, Liu B
Cell communication and signaling : CCS 2022 Oct 27;20(1):168
Cell communication and signaling : CCS 2022 Oct 27;20(1):168
Valdecoxib Protects against Cell Apoptosis Induced by Endoplasmic Reticulum Stress via the Inhibition of PERK-ATF4-CHOP Pathway in Experimental Glaucoma.
Gao Z, Li M, Yao F, Xia X, Duan T, Meng J, Huang Y, He Y, Saro A, Huang J
International journal of molecular sciences 2022 Oct 26;23(21)
International journal of molecular sciences 2022 Oct 26;23(21)
Metformin alleviates bone loss in ovariectomized mice through inhibition of autophagy of osteoclast precursors mediated by E2F1.
Xie X, Hu L, Mi B, Xue H, Hu Y, Panayi AC, Endo Y, Chen L, Yan C, Lin Z, Li H, Zhou W, Liu G
Cell communication and signaling : CCS 2022 Oct 25;20(1):165
Cell communication and signaling : CCS 2022 Oct 25;20(1):165
Network Pharmacology Analysis and Experimental Validation of Kaempferol in the Treatment of Ischemic Stroke by Inhibiting Apoptosis and Regulating Neuroinflammation Involving Neutrophils.
Zhang SS, Liu M, Liu DN, Shang YF, Du GH, Wang YH
International journal of molecular sciences 2022 Oct 21;23(20)
International journal of molecular sciences 2022 Oct 21;23(20)
Polygonatum cyrtonema Hua Polysaccharides Protect BV2 Microglia Relief Oxidative Stress and Ferroptosis by Regulating NRF2/HO-1 Pathway.
Li J, Wang X, Zhou R, Cheng F, Tang X, Lao J, Xu L, He W, Wan D, Zeng H, Zhang S
Molecules (Basel, Switzerland) 2022 Oct 20;27(20)
Molecules (Basel, Switzerland) 2022 Oct 20;27(20)
MicroRNA-21-5p agomir inhibits apoptosis of oligodendrocyte precursor cell and attenuates white matter injury in neonatal rats.
Zhang F, Gou Z, Zhou Y, Huang L, Shao C, Wang M, Wu C, Lu L
Brain research bulletin 2022 Oct 15;189:139-150
Brain research bulletin 2022 Oct 15;189:139-150
Anti-ANGPTL3-FLD monoclonal antibody treatment ameliorates podocyte lesions through attenuating mitochondrial damage.
Lv Q, Han X, Ni J, Ma Q, Dai R, Liu J, Liu J, Zhai Y, Shen Q, Sun L, Liu H, Rao J, Xu H
Cell death & disease 2022 Oct 13;13(10):867
Cell death & disease 2022 Oct 13;13(10):867
Difenoconazole disrupts the blood-brain barrier and results in neurotoxicity in carp by inhibiting the Nrf2 pathway mediated ROS accumulation.
Liu F, Wang Y, Chen L, Bello BK, Zhang T, Yang H, Li X, Pan E, Feng H, Dong J
Ecotoxicology and environmental safety 2022 Oct 1;244:114081
Ecotoxicology and environmental safety 2022 Oct 1;244:114081
miR-1297 sensitizes glioma cells to temozolomide (TMZ) treatment through targeting adrenomedullin (ADM).
He Z, Cheng M, Hu J, Liu L, Liu P, Chen L, Cao D, Tang J
Journal of translational medicine 2022 Oct 1;20(1):443
Journal of translational medicine 2022 Oct 1;20(1):443
Protective effect of hepatocyte-enriched lncRNA-Mir122hg by promoting hepatocyte proliferation in acute liver injury.
Yu Z, Li Y, Shao S, Guo B, Zhang M, Zheng L, Zhang K, Zhou F, Zhang L, Chen C, Jiang W, Hong W, Han T
Experimental & molecular medicine 2022 Nov;54(11):2022-2035
Experimental & molecular medicine 2022 Nov;54(11):2022-2035
An oleanolic acid derivative, K73-03, inhibits pancreatic cancer cells proliferation in vitro and in vivo via blocking EGFR/Akt pathway.
Zhou Z, Dong Y, Li N, Niu M, Wang S, Zhou Y, Sun Z, Chu P, Tang Z
Cell biology international 2022 Nov;46(11):1801-1813
Cell biology international 2022 Nov;46(11):1801-1813
S100A8 regulates autophagy-dependent ferroptosis in microglia after experimental subarachnoid hemorrhage.
Tao Q, Qiu X, Li C, Zhou J, Gu L, Zhang L, Pang J, Zhang L, Yin S, Jiang Y, Peng J
Experimental neurology 2022 Nov;357:114171
Experimental neurology 2022 Nov;357:114171
Targeting the miR-34a/LRPPRC/MDR1 axis collapse the chemoresistance in P53 inactive colorectal cancer.
Yang Y, Yuan H, Zhao L, Guo S, Hu S, Tian M, Nie Y, Yu J, Zhou C, Niu J, Wang G, Song Y
Cell death and differentiation 2022 Nov;29(11):2177-2189
Cell death and differentiation 2022 Nov;29(11):2177-2189
Legumain affects the PI3K/AKT tumor progression pathway in retinoblastoma.
Tang Q, Xu F, Lin J, Zhang C, Liu X, Dong L, Zhao J, Zhu L, Lin T
Experimental eye research 2022 Nov;224:109221
Experimental eye research 2022 Nov;224:109221
N-acetylserotonin protects PC12 cells from hydrogen peroxide induced damage through ROS mediated PI3K / AKT pathway.
Kang J, Wang Y, Guo X, He X, Liu W, Chen H, Wang Z, Lin A, Kang X
Cell cycle (Georgetown, Tex.) 2022 Nov;21(21):2268-2282
Cell cycle (Georgetown, Tex.) 2022 Nov;21(21):2268-2282
Effect of rapamycin treatment on oocyte in vitro maturation and embryonic development after parthenogenesis in yaks.
Zhang T, Wang L, Pan Y, He H, Wang J, Zhao T, Ding T, Wang Y, Zhao L, Han X, Fan J, Xu G, Cui Y, Yu S
Theriogenology 2022 Nov;193:128-135
Theriogenology 2022 Nov;193:128-135
Ellagic Acid Alleviates Mice Intestinal Ischemia-Reperfusion Injury: A Study Based on Transcriptomics Combined with Functional Experiments.
Fan S, Xu Y, Li K, Li B, Diao Y
Chemistry & biodiversity 2022 Nov;19(11):e202200345
Chemistry & biodiversity 2022 Nov;19(11):e202200345
5-Bromo-3,4-dihydroxybenzaldehyde attenuates endothelial cells injury from high glucose-induced damage.
Wang Q, Ou K, Zeng C, Fang Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Nov;155:113793
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Nov;155:113793
Diterpenoids from the whole plant of Euphorbia wallichii and their protective effects on H(2)O(2)-induced BV-2 microglial cells injury.
Wang Y, Zhu M, Liang J, Zhang N, Sun D, Li H, Chen L
Bioorganic chemistry 2022 Nov;128:106067
Bioorganic chemistry 2022 Nov;128:106067
Novel isatin-based hybrids as potential anti-rheumatoid arthritis drug candidates: Synthesis and biological evaluation.
Chen J, Lin X, He J, Liu J, He J, Tao C, Wang Q
Bioorganic chemistry 2022 Nov;128:106063
Bioorganic chemistry 2022 Nov;128:106063
Long-Term Consumption of Food-Derived Chlorogenic Acid Protects Mice against Acetaminophen-Induced Hepatotoxicity via Promoting PINK1-Dependent Mitophagy and Inhibiting Apoptosis.
Hu B, Li J, Gong D, Dai Y, Wang P, Wan L, Xu S
Toxics 2022 Nov 5;10(11)
Toxics 2022 Nov 5;10(11)
GRP75 Modulates Endoplasmic Reticulum-Mitochondria Coupling and Accelerates Ca(2+)-Dependent Endothelial Cell Apoptosis in Diabetic Retinopathy.
Li Y, Li HY, Shao J, Zhu L, Xie TH, Cai J, Wang W, Cai MX, Wang ZL, Yao Y, Wei TT
Biomolecules 2022 Nov 29;12(12)
Biomolecules 2022 Nov 29;12(12)
Ellagic acid attenuates muscle atrophy in STZ-induced diabetic mice.
Liu X, Cheng C, Deng B, Liu M
Physiological research 2022 Nov 28;71(5):631-641
Physiological research 2022 Nov 28;71(5):631-641
Suffruticosol C-Mediated Autophagy and Cell Cycle Arrest via Inhibition of mTORC1 Signaling.
Qin S, Geng H, Wang G, Chen L, Xia C, Yao J, Bai Z, Deng L
Nutrients 2022 Nov 24;14(23)
Nutrients 2022 Nov 24;14(23)
WY-14643 attenuates lipid deposition via activation of the PPARα/CPT1A axis by targeting Gly335 to inhibit cell proliferation and migration in ccRCC.
Wang R, Zhao J, Jin J, Tian Y, Lan L, Wang X, Zhu L, Wang J
Lipids in health and disease 2022 Nov 16;21(1):121
Lipids in health and disease 2022 Nov 16;21(1):121
CD93 promotes acute myeloid leukemia development and is a potential therapeutic target.
Jia J, Liu B, Wang D, Wang X, Song L, Ren Y, Guo Z, Ma K, Cui C
Experimental cell research 2022 Nov 15;420(2):113361
Experimental cell research 2022 Nov 15;420(2):113361
Inhibition of human peptide deformylase by actinonin sensitizes glioblastoma cells to temozolomide chemotherapy.
Lan B, Zhao H, He Y, Zhao Z, Wang N, Gao Y
Experimental cell research 2022 Nov 15;420(2):113358
Experimental cell research 2022 Nov 15;420(2):113358
GRP94 Inhabits the Immortalized Porcine Hepatic Stellate Cells Apoptosis under Endoplasmic Reticulum Stress through Modulating the Expression of IGF-1 and Ubiquitin.
Wang X, Xin H, Zhang C, Gu X, Hao Y
International journal of molecular sciences 2022 Nov 14;23(22)
International journal of molecular sciences 2022 Nov 14;23(22)
Protective Effect of Flavonoids against Methylglyoxal-Induced Oxidative Stress in PC-12 Neuroblastoma Cells and Its Structure-Activity Relationships.
Zhang D, Li X, He X, Xing Y, Jiang B, Xiu Z, Bao Y, Dong Y
Molecules (Basel, Switzerland) 2022 Nov 12;27(22)
Molecules (Basel, Switzerland) 2022 Nov 12;27(22)
NAP1L5 targeting combined with MYH9 Inhibit HCC progression through PI3K/AKT/mTOR signaling pathway.
Zhao R, Ge Y, Gong Y, Li B, Xiao B, Zuo S
Aging 2022 Nov 11;14(22):9000-9019
Aging 2022 Nov 11;14(22):9000-9019
HA-ADT suppresses esophageal squamous cell carcinoma progression via apoptosis promotion and autophagy inhibition.
Duan SF, Zhang MM, Zhang X, Liu W, Zhang SH, Yang B, Dong Q, Han JG, Yu HL, Li T, Ji XY, Wu DD, Zhang XJ
Experimental cell research 2022 Nov 1;420(1):113341
Experimental cell research 2022 Nov 1;420(1):113341
Traditional Chinese medicine CFF-1 exerts a potent anti-tumor immunity to hinder tumor growth and metastasis in prostate cancer through EGFR/JAK1/STAT3 pathway to inhibit PD-1/PD-L1 checkpoint signaling.
Zhang Y, Wei Y, Jiang S, Dang Y, Yang Y, Zuo W, Zhu Q, Liu P, Gao Y, Lu S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 May;99:153939
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 May;99:153939
Maslinic Acid Inhibits Myocardial Ischemia-Reperfusion Injury-Induced Apoptosis and Necroptosis via Promoting Autophagic Flux.
Li L, Lin L, Lei S, Shi S, Chen C, Xia Z
DNA and cell biology 2022 May;41(5):487-497
DNA and cell biology 2022 May;41(5):487-497
HSP90-Mediates Liraglutide Preconditioning-Induced Cardioprotection by Inhibiting C5a and NF-κB.
He ST, Wang DX, Meng JJ, Cheng XF, Bi Q, Zhong GQ, Tu RH
Journal of investigative surgery : the official journal of the Academy of Surgical Research 2022 May;35(5):1012-1020
Journal of investigative surgery : the official journal of the Academy of Surgical Research 2022 May;35(5):1012-1020
TMBIM1 promotes proliferation and attenuates apoptosis in glioblastoma cells by targeting the p38 MAPK signalling pathway.
Cai J, Gao L, Wang Y, Li Y, Ye Z, Tong S, Yan T, Sun Q, Xu Y, Jiang H, Zhang S, Zhao L, Yang J, Chen Q
Translational oncology 2022 May;19:101391
Translational oncology 2022 May;19:101391
A novel ribosomal protein S6 kinase 2 inhibitor attenuates the malignant phenotype of cutaneous malignant melanoma cells by inducing cell cycle arrest and apoptosis.
Li Y, Yu P, Long J, Tang L, Zhang X, Zhou Z, Cao D, Su J, Chen X, Peng C
Bioengineered 2022 May;13(5):13555-13570
Bioengineered 2022 May;13(5):13555-13570
MicroRNA-124 modulates neuroinflammation in acute methanol poisoning rats via targeting Krüppel-like factor-6.
Zhou S, Li J, Zhang X, Xiong W
Bioengineered 2022 May;13(5):13507-13519
Bioengineered 2022 May;13(5):13507-13519
Long non-coding RNA lincRNA-erythroid prosurvival (EPS) alleviates cerebral ischemia/reperfusion injury by maintaining high-temperature requirement protein A1 (Htra1) stability through recruiting heterogeneous nuclear ribonucleoprotein L (HNRNPL).
Guo H, Guo X, Jiang S
Bioengineered 2022 May;13(5):12248-12260
Bioengineered 2022 May;13(5):12248-12260
Recombinant human klotho protects against hydrogen peroxide-mediated injury in human retinal pigment epithelial cells via the PI3K/Akt-Nrf2/HO-1 signaling pathway.
Wen X, Li S, Zhang Y, Zhu L, Xi X, Zhang S, Li Y
Bioengineered 2022 May;13(5):11767-11781
Bioengineered 2022 May;13(5):11767-11781
Single-cell profiling-guided combination therapy of c-Fos and histone deacetylase inhibitors in diffuse large B-cell lymphoma.
Wang L, Wu Z, Xia Y, Lu X, Li J, Fan L, Qiao C, Qiu H, Gu D, Xu W, Li J, Jin H
Clinical and translational medicine 2022 May;12(5):e798
Clinical and translational medicine 2022 May;12(5):e798
Mitochondria-specific peptide amphiphiles induce mitochondrial dysfunction and peripheral T-cell lymphomas (PTCL) damage.
Sun Q, Gui A, Zou A, Yan Y, Qiu S, Zhu S, Liu W, Zuo J, Zhang Q, Yang L
Annals of translational medicine 2022 May;10(10):570
Annals of translational medicine 2022 May;10(10):570
Glucolipotoxicity induces endothelial cell dysfunction by activating autophagy and inhibiting autophagic flow.
Liu Y, Xiang H, Xiong W, Ouyang J, Liu H, Zhao S, Xiao J, Li J, Shu Z, Wang X, Liu H, Zhang J, Fan J, Li Y, Chen S, Lu H
Diabetes & vascular disease research 2022 May-Jun;19(3):14791641221102513
Diabetes & vascular disease research 2022 May-Jun;19(3):14791641221102513
Liver Receptor homolog-1 Regulates Apoptosis of Bovine Ovarian Granulosa Cells by Progestogen Receptor Signaling Pathway.
Xu D, Jiang X, Wang Y, Song S
Animals : an open access journal from MDPI 2022 May 8;12(9)
Animals : an open access journal from MDPI 2022 May 8;12(9)
Therapeutic targeting m6A-guided miR-146a-5p signaling contributes to the melittin-induced selective suppression of bladder cancer.
Yan R, Dai W, Wu R, Huang H, Shu M
Cancer letters 2022 May 28;534:215615
Cancer letters 2022 May 28;534:215615
FBXW2 inhibits prostate cancer proliferation and metastasis via promoting EGFR ubiquitylation and degradation.
Zhou T, Chen T, Lai B, Zhang W, Luo X, Xia D, Fu W, Xu J
Cellular and molecular life sciences : CMLS 2022 May 2;79(5):268
Cellular and molecular life sciences : CMLS 2022 May 2;79(5):268
Taraxasterol prompted the anti-tumor effect in mice burden hepatocellular carcinoma by regulating T lymphocytes.
Ren F, Zhang Y, Qin Y, Shang J, Wang Y, Wei P, Guo J, Jia H, Zhao T
Cell death discovery 2022 May 16;8(1):264
Cell death discovery 2022 May 16;8(1):264
TMCO1 expression promotes cell proliferation and induces epithelial-mesenchymal transformation in human gliomas.
Gao L, Ye Z, Liu JH, Yang JA, Li Y, Cai JY, Wang YX, Tong SA, Deng G, Zhang S, Chen QX
Medical oncology (Northwood, London, England) 2022 May 15;39(5):90
Medical oncology (Northwood, London, England) 2022 May 15;39(5):90
Xiao-Luo-Wan treats propylthiouracil-induced goiter with hypothyroidism in rats through the PI3K-AKT/RAS pathways based on UPLC/MS and network pharmacology.
Dong S, Liu Q, Jiang M, Ma Q, Huang Q, Liu T, Li Y, Ni L, Shi Y
Journal of ethnopharmacology 2022 May 10;289:115045
Journal of ethnopharmacology 2022 May 10;289:115045
Network pharmacology analysis uncovers the effect on apoptotic pathway by Bu-Fei formula for COPD treatment.
Zhang LX, Tian YG, Zhao P, Feng SX, Han XX, Li JS
Journal of ethnopharmacology 2022 May 10;289:115022
Journal of ethnopharmacology 2022 May 10;289:115022
PACS-2 Ameliorates Tubular Injury by Facilitating Endoplasmic Reticulum-Mitochondria Contact and Mitophagy in Diabetic Nephropathy.
Li C, Li L, Yang M, Yang J, Zhao C, Han Y, Zhao H, Jiang N, Wei L, Xiao Y, Liu Y, Xiong X, Xi Y, Luo S, Deng F, Chen W, Yuan S, Zhu X, Xiao L, Sun L
Diabetes 2022 May 1;71(5):1034-1050
Diabetes 2022 May 1;71(5):1034-1050
DT7 peptide-modified lecithin nanoparticles co-loaded with γ-secretase inhibitor and dexamethasone efficiently inhibit T-cell acute lymphoblastic leukemia and reduce gastrointestinal toxicity.
Zhou Y, Guan L, Li W, Jia R, Jia L, Zhang Y, Wen X, Meng S, Ma D, Zhang N, Ji M, Liu Y, Ji C
Cancer letters 2022 May 1;533:215608
Cancer letters 2022 May 1;533:215608
Aberrant translation regulated by METTL1/WDR4-mediated tRNA N7-methylguanosine modification drives head and neck squamous cell carcinoma progression.
Chen J, Li K, Chen J, Wang X, Ling R, Cheng M, Chen Z, Chen F, He Q, Li S, Zhang C, Jiang Y, Chen Q, Wang A, Chen D
Cancer communications (London, England) 2022 Mar;42(3):223-244
Cancer communications (London, England) 2022 Mar;42(3):223-244
The LncRNA RP11-301G19.1/miR-582-5p/HMGB2 axis modulates the proliferation and apoptosis of multiple myeloma cancer cells via the PI3K/AKT signalling pathway.
Wang F, Luo Y, Zhang L, Younis M, Yuan L
Cancer gene therapy 2022 Mar;29(3-4):292-303
Cancer gene therapy 2022 Mar;29(3-4):292-303
Map, but not EspF, induces breast epithelial cell apoptosis through ERK/DRP-1 pathway.
Li Y, Zhu Y, Chu B, Liu N, Chen S, Wang J
Veterinary microbiology 2022 Mar;266:109367
Veterinary microbiology 2022 Mar;266:109367
Proteomic analysis reveals that Xbp1s promotes hypoxic pulmonary hypertension through the p-JNK MAPK pathway.
Jiang H, Niu Y, He Y, Li X, Xu Y, Liu X
Journal of cellular physiology 2022 Mar;237(3):1948-1963
Journal of cellular physiology 2022 Mar;237(3):1948-1963
PP2A promotes apoptosis and facilitates docetaxel sensitivity via the PP2A/p-eIF4B/XIAP signaling pathway in prostate cancer.
Yin S, Chen Y, Tong H, Li T, Qin Z, Zhu J, He W
Oncology letters 2022 Mar;23(3):101
Oncology letters 2022 Mar;23(3):101
Kruppel-like factor 2 acts as a tumor suppressor in human retinoblastoma.
Wu N, Chen S, Luo Q, Jiang Z, Wang X, Li Y, Qiu J, Yu K, Yang Y, Zhuang J
Experimental eye research 2022 Mar;216:108955
Experimental eye research 2022 Mar;216:108955
Inhibition of IRE1 suppresses the catabolic effect of IL-1β on nucleus pulposus cell and prevents intervertebral disc degeneration in vivo.
Kang H, Dong Y, Peng R, Liu H, Guo Q, Song K, Zhu M, Yu K, Wu W, Li F
Biochemical pharmacology 2022 Mar;197:114932
Biochemical pharmacology 2022 Mar;197:114932
Immune-responsive gene 1 protects against liver injury caused by concanavalin A via the activation Nrf2/HO-1 pathway and inhibition of ROS activation pathways.
Yang W, Wang Y, Zhang P, Sun X, Chen X, Yu J, Shi L, Yin Y, Tao K, Li R
Free radical biology & medicine 2022 Mar;182:108-118
Free radical biology & medicine 2022 Mar;182:108-118
Expressions and significances of CTSL, the target of COVID-19 on GBM.
Dong Q, Li Q, Duan L, Wang H, Yan Y, Yin H, Niu L, Zhang H, Wang B, Yuan G, Pan Y
Journal of cancer research and clinical oncology 2022 Mar;148(3):599-608
Journal of cancer research and clinical oncology 2022 Mar;148(3):599-608
SiRNA-circFARSA-loaded porous silicon nanomaterials for pancreatic cancer treatment via inhibition of CircFARSA expression.
Yuan H, Huang X, Li Q, Luo C, Lin C, Zhang S, Zhang Y, Yan Z, Du N, Liu Z, Jiang H, Chen B
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Mar;147:112672
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Mar;147:112672
Shikonin induces apoptosis and autophagy via downregulation of pyrroline-5-carboxylate reductase1 in hepatocellular carcinoma cells.
Zhang J, Shang L, Jiang W, Wu W
Bioengineered 2022 Mar;13(3):7904-7918
Bioengineered 2022 Mar;13(3):7904-7918
Circular RNA triple functional domain promotes osteoarthritis' development by modulating the microRNA-136-5p/Nicotinamide phosphoribosyltransferase axis.
Yang J, Li Q, Wang T, Lv K
Bioengineered 2022 Mar;13(3):6070-6079
Bioengineered 2022 Mar;13(3):6070-6079
Effects of transforming growth factor beta-activated kinase 1 (TAK1) on apoptosis of HK-2 cells in the high glucose environment.
Wang Y, Zhao L, Qiu D, Shi Y, Duan H
Bioengineered 2022 Mar;13(3):5880-5891
Bioengineered 2022 Mar;13(3):5880-5891
Circular RNA SET domain protein 3 promotes nasopharyngeal carcinoma proliferation, cisplatin resistance, and protein kinase B / mammalian target of rapamycin pathway activation by modulating microRNA-147a expression.
Deng G, Wang F, Song Y
Bioengineered 2022 Mar;13(3):5843-5854
Bioengineered 2022 Mar;13(3):5843-5854
Design, synthesis and biological evaluation of marine phidianidine-inspired derivatives against oxidized ldl-induced endothelial injury by activating Nrf2 anti-oxidation pathway.
Xie HX, Wang YH, Zhang JH, Zhang J, Zhong YN, Ge YX, Cheng ZQ, Jiang CS, Meng N
Bioorganic chemistry 2022 Mar;120:105606
Bioorganic chemistry 2022 Mar;120:105606
Complement C1q binding protein regulates T cells' mitochondrial fitness to affect their survival, proliferation, and anti-tumor immune function.
Tian H, Wang G, Wang Q, Zhang B, Jiang G, Li H, Chai D, Fang L, Wang M, Zheng J
Cancer science 2022 Mar;113(3):875-890
Cancer science 2022 Mar;113(3):875-890
Downregulation of NCL attenuates tumor formation and growth in HeLa cells by targeting the PI3K/AKT pathway.
Ying J, Pan R, Tang Z, Zhu J, Ren P, Lou Y, Zhang E, Huang D, Hu P, Li D, Bao Q, Li P
Cancer medicine 2022 Mar;11(6):1454-1464
Cancer medicine 2022 Mar;11(6):1454-1464
Polysaccharides from Platycodonis Radix ameliorated respiratory syncytial virus-induced epithelial cell apoptosis and inflammation through activation of miR-181a-mediated Hippo and SIRT1 pathways.
Li JJ, Liu ML, Lv JN, Chen RL, Ding K, He JQ
International immunopharmacology 2022 Mar;104:108510
International immunopharmacology 2022 Mar;104:108510
Venetoclax enhances NK cell killing sensitivity of AML cells through the NKG2D/NKG2DL activation pathway.
Wu HY, Li KX, Pan WY, Guo MQ, Qiu DZ, He YJ, Li YH, Huang YX
International immunopharmacology 2022 Mar;104:108497
International immunopharmacology 2022 Mar;104:108497
Targeted Polymeric Nanoparticles Based on Mangiferin for Enhanced Protection of Pancreatic β-Cells and Type 1 Diabetes Mellitus Efficacy.
Wang M, Zhang Z, Huo Q, Wang M, Sun Y, Liu H, Chang J, He B, Liang Y
ACS applied materials & interfaces 2022 Mar 9;14(9):11092-11103
ACS applied materials & interfaces 2022 Mar 9;14(9):11092-11103
Tanshinone IIA regulates glycogen synthase kinase-3β-related signaling pathway and ameliorates memory impairment in APP/PS1 transgenic mice.
Peng X, Chen L, Wang Z, He Y, Ruganzu JB, Guo H, Zhang X, Ji S, Zheng L, Yang W
European journal of pharmacology 2022 Mar 5;918:174772
European journal of pharmacology 2022 Mar 5;918:174772
Blocking protease-activated receptor 4 alleviates liver injury induced by brain death.
Fang H, Yuan Z, Zhu Y, Tang H, Pang C, Li J, Shi J, Guo W, Zhang S
Biochemical and biophysical research communications 2022 Mar 5;595:47-53
Biochemical and biophysical research communications 2022 Mar 5;595:47-53
Chlorine disinfection elevates the toxicity of polystyrene microplastics to human cells by inducing mitochondria-dependent apoptosis.
Qin J, Xia PF, Yuan XZ, Wang SG
Journal of hazardous materials 2022 Mar 5;425:127842
Journal of hazardous materials 2022 Mar 5;425:127842
m(6)A mRNA modification maintains colonic epithelial cell homeostasis via NF-κB-mediated antiapoptotic pathway.
Zhang T, Ding C, Chen H, Zhao J, Chen Z, Chen B, Mao K, Hao Y, Roulis M, Xu H, Kluger Y, Zou Q, Ye Y, Zhan M, Flavell RA, Li HB
Science advances 2022 Mar 25;8(12):eabl5723
Science advances 2022 Mar 25;8(12):eabl5723
Curcumin ameliorates HO-induced injury through SIRT1-PERK-CHOP pathway in pancreatic beta cells.
Cao Z, Wu Z, Duan T, Tang C, Huang D, Hu X
Acta biochimica et biophysica Sinica 2022 Mar 25;54(3):370-377
Acta biochimica et biophysica Sinica 2022 Mar 25;54(3):370-377
Autophagy Promotes α-Amanitin-Induced Apoptosis of Hepa1-6 Liver Cells.
Gu X, Zhang L, Sun W, Liu K, Xu H, Wu P, Gui M, Qu W
Chemical research in toxicology 2022 Mar 21;35(3):392-401
Chemical research in toxicology 2022 Mar 21;35(3):392-401
Dioscin relieves diabetic nephropathy via suppressing oxidative stress and apoptosis, and improving mitochondrial quality and quantity control.
Zhong Y, Liu J, Sun D, Guo T, Yao Y, Xia X, Shi C, Peng X
Food & function 2022 Mar 21;13(6):3660-3673
Food & function 2022 Mar 21;13(6):3660-3673
Dihydrohomoplantagin and Homoplantaginin, Major Flavonoid Glycosides from Salvia plebeia R. Br. Inhibit oxLDL-Induced Endothelial Cell Injury and Restrict Atherosclerosis via Activating Nrf2 Anti-Oxidation Signal Pathway.
Meng N, Chen K, Wang Y, Hou J, Chu W, Xie S, Yang F, Sun C
Molecules (Basel, Switzerland) 2022 Mar 19;27(6)
Molecules (Basel, Switzerland) 2022 Mar 19;27(6)
Chelerythrine inhibits the progression of glioblastoma by suppressing the TGFB1-ERK1/2/Smad2/3-Snail/ZEB1 signaling pathway.
Zhu M, Niu J, Jiang J, Dong T, Chen Y, Yang X, Liu P
Life sciences 2022 Mar 15;293:120358
Life sciences 2022 Mar 15;293:120358
Pan-cancer analysis, cell and animal experiments revealing TEAD4 as a tumor promoter in ccRCC.
Li F, Feng Y, Jiang Q, Zhang J, Wu F, Li Q, Jing X, Wang X, Huang C
Life sciences 2022 Mar 15;293:120327
Life sciences 2022 Mar 15;293:120327
Protective Effects of Taraxasterol against Deoxynivalenol-Induced Damage to Bovine Mammary Epithelial Cells.
Wang J, Zheng K, Jin Y, Fu Y, Wang R, Zhang J
Toxins 2022 Mar 15;14(3)
Toxins 2022 Mar 15;14(3)
Inhibition of STAT3(Y705) phosphorylation by Stattic suppresses proliferation and induces mitochondrial-dependent apoptosis in pancreatic cancer cells.
Guo H, Xiao Y, Yuan Z, Yang X, Chen J, Chen C, Wang M, Xie L, Chen Q, Tong Y, Zhang Q, Bai Y
Cell death discovery 2022 Mar 14;8(1):116
Cell death discovery 2022 Mar 14;8(1):116
The Novel Competing Endogenous Long Noncoding RNA SM2 Regulates Gonadotropin Secretion in the Hu Sheep Anterior Pituitary by Targeting the Oar-miR-16b/TGF-β/SMAD2 Signaling Pathway.
Wan Z, Yang H, Chen P, Wang Z, Cai Y, Yao X, Wang F, Zhang Y
Cells 2022 Mar 14;11(6)
Cells 2022 Mar 14;11(6)
Knockdown of long noncoding RNA MIAT attenuates cigarette smoke-induced airway remodeling by downregulating miR-29c-3p-HIF3A axis.
Gu W, Wang L, Deng G, Gu X, Tang Z, Li S, Jin W, Yang J, Guo X, Li Q
Toxicology letters 2022 Mar 1;357:11-19
Toxicology letters 2022 Mar 1;357:11-19
Oxidative stress activates Ryr2-Ca(2+) and apoptosis to promote PM(2.5)-induced heart injury of hyperlipidemia mice.
Meng M, Jia R, Wei M, Meng X, Zhang X, Du R, Sun W, Wang L, Song L
Ecotoxicology and environmental safety 2022 Mar 1;232:113228
Ecotoxicology and environmental safety 2022 Mar 1;232:113228
Low energy shock wave therapy attenuates mitochondrial dysfunction and improves bladder function in HCl induced cystitis in rats.
Wang HJ, Tyagi P, Lin TK, Huang CC, Lee WC, Chancellor MB, Chuang YC
Biomedical journal 2022 Jun;45(3):482-490
Biomedical journal 2022 Jun;45(3):482-490
Protection of CAPE-pNO(2) Against Chronic Myocardial Ischemia by the TGF-Β1/Galectin-3 Pathway In Vivo and In Vitro.
Wan Q, Zhang L, Zhou Q, Han Y, Li Z, Li B
Inflammation 2022 Jun;45(3):1039-1058
Inflammation 2022 Jun;45(3):1039-1058
LncRNA small nucleolar RNA host gene 16 reduces sepsis-induced myocardial damage by regulating miR-421/suppressor of cytokine signaling 5 axis.
Yu M, Xie D, Hu CY, Cui Y
The Kaohsiung journal of medical sciences 2022 Jun;38(6):517-529
The Kaohsiung journal of medical sciences 2022 Jun;38(6):517-529
Naringin alleviates acetaminophen-induced acute liver injury by activating Nrf2 via CHAC2 upregulation.
Zhai X, Dai T, Chi Z, Zhao Z, Wu G, Yang S, Dong D
Environmental toxicology 2022 Jun;37(6):1332-1342
Environmental toxicology 2022 Jun;37(6):1332-1342
microRNA-486-5p is implicated in the cisplatin-induced apoptosis and acute inflammation response of renal tubular epithelial cells by targeting HAT1.
Lin FY, Han ST, Yu WM, Rao T, Ruan Y, Yuan R, Li HY, Ning JZ, Xia YQ, Xie JN, Qi YC, Zhou XJ, Cheng F
Journal of biochemical and molecular toxicology 2022 Jun;36(6):e23039
Journal of biochemical and molecular toxicology 2022 Jun;36(6):e23039
In situ forming and biocompatible hyaluronic acid hydrogel with reactive oxygen species-scavenging activity to improve traumatic brain injury repair by suppressing oxidative stress and neuroinflammation.
Zhang D, Ren Y, He Y, Chang R, Guo S, Ma S, Guan F, Yao M
Materials today. Bio 2022 Jun;15:100278
Materials today. Bio 2022 Jun;15:100278
Effect of miR-101 on the Proliferation and Apoptosis of Goat Hair Follicle Stem Cells.
Qu J, Wu X, Wang Q, Wang J, Sun X, Ji D, Li Y
Genes 2022 Jun 9;13(6)
Genes 2022 Jun 9;13(6)
Carboxymethyl Chitosan Modified Oxymatrine Liposomes for the Alleviation of Emphysema in Mice via Pulmonary Administration.
Peng J, Cai Z, Wang Q, Zhou J, Xu J, Pan D, Chen T, Zhang G, Tao L, Chen Y, Shen X
Molecules (Basel, Switzerland) 2022 Jun 4;27(11)
Molecules (Basel, Switzerland) 2022 Jun 4;27(11)
CircEZH2/miR-133b/IGF2BP2 aggravates colorectal cancer progression via enhancing the stability of m(6)A-modified CREB1 mRNA.
Yao B, Zhang Q, Yang Z, An F, Nie H, Wang H, Yang C, Sun J, Chen K, Zhou J, Bai B, Gu S, Zhao W, Zhan Q
Molecular cancer 2022 Jun 30;21(1):140
Molecular cancer 2022 Jun 30;21(1):140
Design, Synthesis, and Biological Evaluation of N14-Amino Acid-Substituted Tetrandrine Derivatives as Potential Antitumor Agents against Human Colorectal Cancer.
Wang YC, Zhang RH, Hu SC, Zhang H, Yang D, Zhang WL, Zhao YL, Cui DB, Li YJ, Pan WD, Liao SG, Zhou M
Molecules (Basel, Switzerland) 2022 Jun 23;27(13)
Molecules (Basel, Switzerland) 2022 Jun 23;27(13)
Pharmacological Inhibition of Endogenous Hydrogen Sulfide Attenuates Breast Cancer Progression.
Khan NH, Wang D, Wang W, Shahid M, Khattak S, Ngowi EE, Sarfraz M, Ji XY, Zhang CY, Wu DD
Molecules (Basel, Switzerland) 2022 Jun 23;27(13)
Molecules (Basel, Switzerland) 2022 Jun 23;27(13)
A novel phosphodiesterase 9A inhibitor LW33 protects against ischemic stroke through the cGMP/PKG/CREB pathway.
You JY, Liu XW, Bao YX, Shen ZN, Wang Q, He GY, Lu J, Zhang JG, Chen JW, Liu PQ
European journal of pharmacology 2022 Jun 15;925:174987
European journal of pharmacology 2022 Jun 15;925:174987
Comparative and mechanistic study of pharmacodynamic difference in anti-breast cancer activity between water and liquor extracts of Xiaojin Pills.
Liu H, Cao B, Li C, Han L, Xu H, Lin J, Zhang D, Xu R
Journal of ethnopharmacology 2022 Jun 12;291:115104
Journal of ethnopharmacology 2022 Jun 12;291:115104
Platelet-Membrane-Encapsulated Carvedilol with Improved Targeting Ability for Relieving Myocardial Ischemia-Reperfusion Injury.
Zhou T, Yang X, Wang T, Xu M, Huang Z, Yu R, Jiang Y, Zhou Y, Shi J
Membranes 2022 Jun 10;12(6)
Membranes 2022 Jun 10;12(6)
METTL3 mediates osteoblast apoptosis by regulating endoplasmic reticulum stress during LPS-induced inflammation.
Kong Y, Zhang Y, Cai Y, Li D, Yi B, Xu Q
Cellular signalling 2022 Jul;95:110335
Cellular signalling 2022 Jul;95:110335
Loss of cell division cycle‑associated 5 promotes cell apoptosis by activating DNA damage response in clear cell renal cell carcinoma.
Huang X, Huang Y, Lv Z, Wang T, Feng H, Wang H, Du S, Wu S, Shen D, Wang C, Li H, Wang B, Ma X, Zhang X
International journal of oncology 2022 Jul;61(1)
International journal of oncology 2022 Jul;61(1)
Dopamine 1 receptors inhibit apoptosis via activating CSE/H(2) S pathway in high glucose-induced vascular endothelial cells.
Li H, Wu R, Xi Y, Li H, Chang G, Sun F, Wei C, Jiao L, Wen X, Zhang G, Zaid A, Hao J
Cell biology international 2022 Jul;46(7):1098-1108
Cell biology international 2022 Jul;46(7):1098-1108
Inhibition of PDK1 enhances radiosensitivity and reverses epithelial-mesenchymal transition in nasopharyngeal carcinoma.
Zhang W, Li L, Guo E, Zhou H, Ming J, Sun L, Hu G, Zhang L
Head & neck 2022 Jul;44(7):1576-1587
Head & neck 2022 Jul;44(7):1576-1587
Melatonin improves bisphenol A-induced cell apoptosis, oxidative stress and autophagy impairment via inhibition of the p38 MAPK signaling pathway in FLK-BLV cells.
Song D, Liu Y, Yao Y, Liu F, Tao W, Zhou X, Li R, Zhang X, Li X
Environmental toxicology 2022 Jul;37(7):1551-1562
Environmental toxicology 2022 Jul;37(7):1551-1562
MicroRNA profiling reveals miR-145-5p inhibits goat myoblast differentiation by targeting the coding domain sequence of USP13.
Zhang Z, Deng K, Kang Z, Wang F, Fan Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Jul;36(7):e22370
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Jul;36(7):e22370
The mitochondrial protein Sideroflexin 3 (SFXN3) influences neurodegeneration pathways in vivo.
Ledahawsky LM, Terzenidou ME, Edwards R, Kline RA, Graham LC, Eaton SL, van der Hoorn D, Chaytow H, Huang YT, Groen EJN, Motyl AAL, Lamont DJ, Tokatlidis K, Wishart TM, Gillingwater TH
The FEBS journal 2022 Jul;289(13):3894-3914
The FEBS journal 2022 Jul;289(13):3894-3914
SERPINA1 is a hub gene associated with intervertebral disc degeneration grade and affects the nucleus pulposus cell phenotype through the ADIRF-AS1/miR-214-3p axis.
Zhong H, Zhou Z, Guo L, Liu FS, Wang X, Li J, Lv GH, Zou MX
Translational research : the journal of laboratory and clinical medicine 2022 Jul;245:99-116
Translational research : the journal of laboratory and clinical medicine 2022 Jul;245:99-116
Insulin and liraglutide attenuate brain pathology in diabetic mice by enhancing the Wnt/β-catenin signaling pathway.
Zhao Y, Yu J, Ping F, Xu L, Li W, Zhang H, Li Y
Experimental and therapeutic medicine 2022 Jul;24(1):439
Experimental and therapeutic medicine 2022 Jul;24(1):439
Berberine exerts protective effects on cardiac senescence by regulating the Klotho/SIRT1 signaling pathway.
Li C, Jiang S, Wang H, Wang Y, Han Y, Jiang J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jul;151:113097
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jul;151:113097
Effect of alfalfa substituted with ramie on the expression of apoptotic genes in the gastrointestinal tracts of goats.
Liu Q, Fu C, Yang H, Zhou C, Kang J, Chen L, Kong Z, Tan Z, Tang S
Food science & nutrition 2022 Jul;10(7):2400-2407
Food science & nutrition 2022 Jul;10(7):2400-2407
Box C/D snoRNA SNORD89 influences the occurrence and development of endometrial cancer through 2'-O-methylation modification of Bim.
Bao HJ, Chen X, Liu X, Wu W, Li QH, Xian JY, Zhao Y, Chen S
Cell death discovery 2022 Jul 5;8(1):309
Cell death discovery 2022 Jul 5;8(1):309
Akkermansia muciniphila Colonization Alleviating High Fructose and Restraint Stress-Induced Jejunal Mucosal Barrier Disruption.
Yu J, Liu T, Gao Z, Liu R, Wang Z, Chen Y, Cao J, Dong Y
Nutrients 2022 Jul 30;14(15)
Nutrients 2022 Jul 30;14(15)
T-2 Toxin Induces Apoptotic Cell Death and Protective Autophagy in Mouse Microglia BV2 Cells.
Sun T, Zhang Q, Li M, Tang S, Dai C
Journal of fungi (Basel, Switzerland) 2022 Jul 22;8(8)
Journal of fungi (Basel, Switzerland) 2022 Jul 22;8(8)
Revealing the mechanism of Jiegeng decoction attenuates bleomycin-induced pulmonary fibrosis via PI3K/Akt signaling pathway based on lipidomics and transcriptomics.
Xu Y, Wang X, Han D, Wang J, Luo Z, Jin T, Shi C, Zhou X, Lin L, Shan J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jul 20;102:154207
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jul 20;102:154207
SIRT4 functions as a tumor suppressor during prostate cancer by inducing apoptosis and inhibiting glutamine metabolism.
Cai G, Ge Z, Xu Y, Cai L, Sun P, Huang G
Scientific reports 2022 Jul 16;12(1):12208
Scientific reports 2022 Jul 16;12(1):12208
A small-molecule Skp1 inhibitor elicits cell death by p53-dependent mechanism.
Hussain M, Lu Y, Tariq M, Jiang H, Shu Y, Luo S, Zhu Q, Zhang J, Liu J
iScience 2022 Jul 15;25(7):104591
iScience 2022 Jul 15;25(7):104591
RBM47 inhibits hepatocellular carcinoma progression by targeting UPF1 as a DNA/RNA regulator.
Guo T, You K, Chen X, Sun Y, Wu Y, Wu P, Jiang Y
Cell death discovery 2022 Jul 14;8(1):320
Cell death discovery 2022 Jul 14;8(1):320
Effects of bamboo leaf extract intervention on the growth performance, antioxidant capacity, and hepatic apoptosis in suckling piglets.
Yu G, Ji S, Yun Y, Cheng K, Zhang H, Jia P, Wang T, Zhang L
Journal of animal science 2022 Jul 1;100(7)
Journal of animal science 2022 Jul 1;100(7)
Study on the new anti-atherosclerosis activity of different Herba patriniae through down-regulating lysophosphatidylcholine of the glycerophospholipid metabolism pathway.
Su D, Liao L, Zeng Q, Liao Z, Liu Y, Jin C, Zhu G, Chen C, Yang M, Ai Z, Song Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;94:153833
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;94:153833
Expression pattern of alkB homolog 5 in goat testis and its role in spermatogonial stem cells.
Liu Z, Cai Y, Deng M, Li D, Leng Q, Shi L, Tang Y, Wang F, Wan Y
Cell and tissue research 2022 Jan;387(1):131-142
Cell and tissue research 2022 Jan;387(1):131-142
PKM2 compensates for proteasome dysfunction by mediating the formation of the CHIP-HSP70-BAG3 complex and the aggregation of ubiquitinated proteins.
Zhang C, Tang Q, Xia H, Xu H, Bi F
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Jan;36(1):e22121
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Jan;36(1):e22121
Circular RNA circUSP13 sponges miR-29c to promote differentiation and inhibit apoptosis of goat myoblasts by targeting IGF1.
Zhang Z, Fan Y, Deng K, Liang Y, Zhang G, Gao X, El-Samahy MA, Zhang Y, Deng M, Wang F
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Jan;36(1):e22097
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Jan;36(1):e22097
TRIM59 promotes osteosarcoma progression via activation of STAT3.
Xu G, Ma Z, Yang F, Bai Y, Li J, Luo W, Zhong J
Human cell 2022 Jan;35(1):250-259
Human cell 2022 Jan;35(1):250-259
Carrier-Free Delivery of Ultrasmall π-Conjugated Oligomer Nanoparticles with Photothermal Conversion over 80% for Cancer Theranostics.
Zheng R, Zhao Q, Qing W, Li S, Liu Z, Li Q, Huang Y
Small (Weinheim an der Bergstrasse, Germany) 2022 Jan;18(4):e2104521
Small (Weinheim an der Bergstrasse, Germany) 2022 Jan;18(4):e2104521
Ki20227 aggravates apoptosis, inflammatory response, and oxidative stress after focal cerebral ischemia injury.
Jiang C, Wang ZN, Kang YC, Chen Y, Lu WX, Ren HJ, Hou BR
Neural regeneration research 2022 Jan;17(1):137-143
Neural regeneration research 2022 Jan;17(1):137-143
Jujuboside A ameliorates high fat diet and streptozotocin induced diabetic nephropathy via suppressing oxidative stress, apoptosis, and enhancing autophagy.
Zhong Y, Luo R, Liu Q, Zhu J, Lei M, Liang X, Wang X, Peng X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Jan;159:112697
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Jan;159:112697
Targeting the Pro-survival Protein BCL-2 to Prevent Breast Cancer.
Young A, Bu W, Jiang W, Ku A, Kapali J, Dhamne S, Qin L, Hilsenbeck SG, Du YN, Li Y
Cancer prevention research (Philadelphia, Pa.) 2022 Jan;15(1):3-10
Cancer prevention research (Philadelphia, Pa.) 2022 Jan;15(1):3-10
Knockdown of forkhead box protein P1 alleviates hypoxia reoxygenation injury in H9c2 cells through regulating Pik3ip1/Akt/eNOS and ROS/mPTP pathway.
Liu X, Yang Y, Song J, Li D, Liu X, Li C, Ma Z, Zhong J, Wang L
Bioengineered 2022 Jan;13(1):1320-1334
Bioengineered 2022 Jan;13(1):1320-1334
Injectable hyaluronic acid hydrogel loaded with BMSC and NGF for traumatic brain injury treatment.
Wang L, Zhang D, Ren Y, Guo S, Li J, Ma S, Yao M, Guan F
Materials today. Bio 2022 Jan;13:100201
Materials today. Bio 2022 Jan;13:100201
Inhibition of CDK1 attenuates neuronal apoptosis and autophagy and confers neuroprotection after chronic spinal cord injury in vivo.
Nie BX, Zhao G, Yuan XF, Yu LX, Zhang J, Yuan Y, Liu Y, Hu J, Song E, Zhou YC, Shu J
Journal of chemical neuroanatomy 2022 Jan;119:102053
Journal of chemical neuroanatomy 2022 Jan;119:102053
Inhibition of the proliferation, invasion, migration, and epithelial-mesenchymal transition of prostate cancer cells through the action of ATP1A2 on the TGF-β/Smad pathway.
Zhang B, Zhu Z, Zhang X, Li F, Ding A
Translational andrology and urology 2022 Jan;11(1):53-66
Translational andrology and urology 2022 Jan;11(1):53-66
Cotargeting of Bcl-2 and Mcl-1 shows promising antileukemic activity against AML cells including those with acquired cytarabine resistance.
Liu F, Zhao Q, Su Y, Lv J, Gai Y, Liu S, Lin H, Wang Y, Wang G
Experimental hematology 2022 Jan;105:39-49
Experimental hematology 2022 Jan;105:39-49
Deglycosylated EpCAM regulates proliferation by enhancing autophagy of breast cancer cells via PI3K/Akt/mTOR pathway.
Yang L, Wang Q, Zhao Q, Yang F, Liu T, Huang X, Yan Q, Yang X
Aging 2022 Jan 4;14(1):316-329
Aging 2022 Jan 4;14(1):316-329
Involvement of caspase in patulin-induced hepatotoxicity in vitro and in vivo.
Zhang B, Huang C, Lu Q, Liang H, Li J, Xu D
Toxicon : official journal of the International Society on Toxinology 2022 Jan 30;206:64-73
Toxicon : official journal of the International Society on Toxinology 2022 Jan 30;206:64-73
The bibenzyl derivatives of Dendrobium officinale prevent UV-B irradiation induced photoaging via SIRT3.
Chen DK, Shao HY, Yang L, Hu JM
Natural products and bioprospecting 2022 Jan 27;12(1):1
Natural products and bioprospecting 2022 Jan 27;12(1):1
Betulinic acid self-assembled nanoparticles for effective treatment of glioblastoma.
Li Y, Wang Y, Gao L, Tan Y, Cai J, Ye Z, Chen AT, Xu Y, Zhao L, Tong S, Sun Q, Liu B, Zhang S, Tian D, Deng G, Zhou J, Chen Q
Journal of nanobiotechnology 2022 Jan 21;20(1):39
Journal of nanobiotechnology 2022 Jan 21;20(1):39
4,5-Dimethoxycanthin-6-one is a novel LSD1 inhibitor that inhibits proliferation of glioblastoma cells and induces apoptosis and pyroptosis.
Li W, Huang BS, Xiong YY, Yang LJ, Wu LX
Cancer cell international 2022 Jan 18;22(1):32
Cancer cell international 2022 Jan 18;22(1):32
Salidroside alleviates oxidative stress and apoptosis via AMPK/Nrf2 pathway in DHT-induced human granulosa cell line KGN.
Ji R, Jia FY, Chen X, Wang ZH, Jin WY, Yang J
Archives of biochemistry and biophysics 2022 Jan 15;715:109094
Archives of biochemistry and biophysics 2022 Jan 15;715:109094
Inhibition of Rac1 attenuates radiation-induced lung injury while suppresses lung tumor in mice.
An N, Li Z, Yan X, Zhao H, Yang Y, Liu R, Yang Y, Gao F, Li B, Liu H, Yuan H
Cell death discovery 2022 Jan 14;8(1):26
Cell death discovery 2022 Jan 14;8(1):26
Short-term starvation synergistically enhances cytotoxicity of Niraparib via Akt/mTOR signaling pathway in ovarian cancer therapy.
Zhi W, Li S, Wan Y, Wu F, Hong L
Cancer cell international 2022 Jan 11;22(1):18
Cancer cell international 2022 Jan 11;22(1):18
Anti-tumor effect of Yanggan Huayu granule by inducing AKT-mediated apoptosis in hepatocellular carcinoma.
Shen Y, Yang F, Peng H, Zhang G, Zhu F, Xu H, Shi L
Journal of ethnopharmacology 2022 Jan 10;282:114601
Journal of ethnopharmacology 2022 Jan 10;282:114601
ATF4/CEMIP/PKCα promotes anoikis resistance by enhancing protective autophagy in prostate cancer cells.
Yu Y, Liu B, Li X, Lu D, Yang L, Chen L, Li Y, Cheng L, Lv F, Zhang P, Song Y, Xing Y
Cell death & disease 2022 Jan 10;13(1):46
Cell death & disease 2022 Jan 10;13(1):46
Lactobacillus rhamnosus Ameliorates Multi-Drug-Resistant Bacillus cereus-Induced Cell Damage through Inhibition of NLRP3 Inflammasomes and Apoptosis in Bovine Endometritis.
Liu N, Wang X, Shan Q, Xu L, Li Y, Chu B, Yang L, Wang J, Zhu Y
Microorganisms 2022 Jan 10;10(1)
Microorganisms 2022 Jan 10;10(1)
Downregulation of HSPA12A underlies myotoxicity of local anesthetic agent bupivacaine through inhibiting PGC1α-mediated mitochondrial integrity.
Mao Q, Yu W, Liu S, Cao X, Dai Y, Zhang X, Min X, Liu L, Ding Z
Toxicology and applied pharmacology 2022 Jan 1;434:115798
Toxicology and applied pharmacology 2022 Jan 1;434:115798
Pre-ischemic exercise prevents inflammation and apoptosis by inhibiting MAPK pathway in ischemic stroke.
Gao ZK, Shen XY, Han Y, Guo YS, Li K, Bi X
Translational neuroscience 2022 Jan 1;13(1):495-505
Translational neuroscience 2022 Jan 1;13(1):495-505
Integrating network pharmacology deciphers the action mechanism of Zuojin capsule in suppressing colorectal cancer.
Fan JH, Xu MM, Zhou LM, Gui ZW, Huang L, Li XG, Ye XL
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Feb;96:153881
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Feb;96:153881
Lysophosphatidylcholine disrupts cell adhesion and induces anoikis in hepatocytes.
Chen H, Ma J, Liu J, Dou L, Shen T, Zuo H, Xu F, Zhao L, Tang W, Man Y, Ma Y, Li J, Huang X
FEBS letters 2022 Feb;596(4):510-525
FEBS letters 2022 Feb;596(4):510-525
Inhibition of gap junction communication between cells can induce apoptosis of corpus cavernosum smooth muscle in guinea pigs.
Wang Y, Wang J, Hao Z, Yang H, Li Y, Tan M, Liu L, Feng S, Mei L, Qian B
Andrologia 2022 Feb;54(1):e14287
Andrologia 2022 Feb;54(1):e14287
Inhibition of the miR-193b-3p protects against oxidized low-density lipoprotein-induced HUVECs injury by upregulating ALDH2.
Bai Y, Wang M, Yang Y, Liu X, Chen Q, Guo Z
Cell biology international 2022 Feb;46(2):192-202
Cell biology international 2022 Feb;46(2):192-202
MiR-4521 plays a tumor repressive role in growth and metastasis of hepatocarcinoma cells by suppressing phosphorylation of FAK/AKT pathway via targeting FAM129A.
Ayesha M, Majid A, Zhao D, Greenaway FT, Yan N, Liu Q, Liu S, Sun MZ
Journal of advanced research 2022 Feb;36:147-161
Journal of advanced research 2022 Feb;36:147-161
SKI knockdown suppresses apoptosis and extracellular matrix degradation of nucleus pulposus cells via inhibition of the Wnt/β-catenin pathway and ameliorates disc degeneration.
Wu ZL, Chen YJ, Zhang GZ, Xie QQ, Wang KP, Yang X, Liu TC, Wang ZQ, Zhao GH, Zhang HH
Apoptosis : an international journal on programmed cell death 2022 Feb;27(1-2):133-148
Apoptosis : an international journal on programmed cell death 2022 Feb;27(1-2):133-148
Extracellular vesicles of Lacticaseibacillus paracasei PC-H1 induce colorectal cancer cells apoptosis via PDK1/AKT/Bcl-2 signaling pathway.
Shi Y, Meng L, Zhang C, Zhang F, Fang Y
Microbiological research 2022 Feb;255:126921
Microbiological research 2022 Feb;255:126921
Combination of the 6-thioguanine and disulfiram/Cu synergistically inhibits proliferation of triple-negative breast cancer cells by enhancing DNA damage and disrupting DNA damage checkpoint.
Chu M, An X, Zhang D, Li Q, Dai X, Yu H, Li Z
Biochimica et biophysica acta. Molecular cell research 2022 Feb;1869(2):119169
Biochimica et biophysica acta. Molecular cell research 2022 Feb;1869(2):119169
Inhibition of microRNA-29b suppresses oxidative stress and reduces apoptosis in ischemic stroke.
Ma YH, Deng WJ, Luo ZY, Jing J, Pan PW, Yao YB, Fang YB, Teng JF
Neural regeneration research 2022 Feb;17(2):433-439
Neural regeneration research 2022 Feb;17(2):433-439
Genistein alleviates renin-angiotensin system mediated vascular and kidney alterations in renovascular hypertensive rats.
Poasakate A, Maneesai P, Potue P, Bunbupha S, Tong-Un T, Settheetham-Ishida W, Khamseekaew J, Pakdeechote P
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Feb;146:112601
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Feb;146:112601
Polygonum cuspidatum inhibits the growth of osteosarcoma cells via impeding Akt/ERK/EGFR signaling pathways.
Zhao J, Pan B, Zhou X, Wu C, Hao F, Zhang J, Liu L
Bioengineered 2022 Feb;13(2):2992-3006
Bioengineered 2022 Feb;13(2):2992-3006
Knockdown of long non-coding RNA plasmacytoma variant translocation 1 relieves ox-LDL-induced endothelial cell injury through regulating microRNA-30c-5p in atherosclerosis.
Li G, Zong W, Liu L, Wu J, Pang J
Bioengineered 2022 Feb;13(2):2791-2802
Bioengineered 2022 Feb;13(2):2791-2802
Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy.
Sun X, Shu Y, Ye G, Wu C, Xu M, Gao R, Huang D, Zhang J
Acta pharmaceutica Sinica. B 2022 Feb;12(2):838-852
Acta pharmaceutica Sinica. B 2022 Feb;12(2):838-852
Integrative investigation of the TF-miRNA coregulatory network involved in the inhibition of breast cancer cell proliferation by resveratrol.
Zhou Y, Zhang J, Li W, Zhang D, Wang Z, Zhai Y, Yu H, Li Z
FEBS open bio 2022 Feb;12(2):379-393
FEBS open bio 2022 Feb;12(2):379-393
MiR-187 regulates the proliferation, migration and invasion of human trophoblast cells by repressing BCL6-mediated activation of PI3K/AKT signaling.
Chen X, Song QL, Ji R, Wang JY, Li ZH, Guo D, Yin TL, Wang SJ, Yang J
Placenta 2022 Feb;118:20-31
Placenta 2022 Feb;118:20-31
Berberine ameliorates erectile dysfunction in rats with streptozotocin-induced diabetes mellitus through the attenuation of apoptosis by inhibiting the SPHK1/S1P/S1PR2 and MAPK pathways.
Liu K, Sun T, Luan Y, Chen Y, Song J, Ling L, Yuan P, Li R, Cui K, Ruan Y, Lan R, Wang T, Wang S, Liu J, Rao K
Andrology 2022 Feb;10(2):404-418
Andrology 2022 Feb;10(2):404-418
Long non-coding RNA MALAT1 modulates myocardial ischemia-reperfusion injury through the PI3K/Akt/eNOS pathway by sponging miRNA-133a-3p to target IGF1R expression.
Liu XM, Zhang Z, Zhong J, Li N, Wang T, Wang L, Zhang Q
European journal of pharmacology 2022 Feb 5;916:174719
European journal of pharmacology 2022 Feb 5;916:174719
Design and synthesis of marine sesterterpene analogues as novel estrogen receptor α degraders for breast cancer treatment.
Liang JJ, Yu WL, Yang L, Xie BH, Qin KM, Yin YP, Yan JJ, Gong S, Liu TY, Zhou HB, Hong K
European journal of medicinal chemistry 2022 Feb 5;229:114081
European journal of medicinal chemistry 2022 Feb 5;229:114081
miR-196a Upregulation Contributes to Gefitinib Resistance through Inhibiting GLTP Expression.
Liu BJ, Li FF, Xie YX, Fan CY, Liu WJ, Qiu JG, Jiang BH
International journal of molecular sciences 2022 Feb 4;23(3)
International journal of molecular sciences 2022 Feb 4;23(3)
Targeting and neutralizing human epididymis protein 4 by novel nanobodies to suppress ovarian cancer cells and attenuate cisplatin resistance.
Yu J, Guo Y, Gu Y, Li F, Song H, Nian R, Fan X, Liu W
International journal of biological macromolecules 2022 Feb 28;199:298-306
International journal of biological macromolecules 2022 Feb 28;199:298-306
Inhibition of Ceramide Glycosylation Enhances Cisplatin Sensitivity in Cholangiocarcinoma by Limiting the Activation of the ERK Signaling Pathway.
Chueakwon P, Jatooratthawichot P, Talabnin K, Ketudat Cairns JR, Talabnin C
Life (Basel, Switzerland) 2022 Feb 28;12(3)
Life (Basel, Switzerland) 2022 Feb 28;12(3)
Hepatic Ischemia-reperfusion Injury in Mice was Alleviated by Rac1 Inhibition - More Than Just ROS-inhibition.
Sha Z, Yang Y, Liu R, Bao H, Song S, Dong J, Guo M, Zhao Y, Liu H, Ding G
Journal of clinical and translational hepatology 2022 Feb 28;10(1):42-52
Journal of clinical and translational hepatology 2022 Feb 28;10(1):42-52
FTO protects human granulosa cells from chemotherapy-induced cytotoxicity.
Wang R, Wang W, Wang L, Yuan L, Cheng F, Guan X, Zheng N, Yang X
Reproductive biology and endocrinology : RB&E 2022 Feb 26;20(1):39
Reproductive biology and endocrinology : RB&E 2022 Feb 26;20(1):39
Perfluorooctanoic acid induces hepatocellular endoplasmic reticulum stress and mitochondrial-mediated apoptosis in vitro via endoplasmic reticulum-mitochondria communication.
Wang Q, Chen W, Zhang B, Gao Z, Zhang Q, Deng H, Han L, Shen XL
Chemico-biological interactions 2022 Feb 25;354:109844
Chemico-biological interactions 2022 Feb 25;354:109844
Isovitexin protects against acute liver injury by targeting PTEN, PI3K and BiP via modification of m6A.
Huang Y, Chen S, Pang L, Feng Z, Su H, Zhu W, Wei J
European journal of pharmacology 2022 Feb 15;917:174749
European journal of pharmacology 2022 Feb 15;917:174749
RRM2 Alleviates Doxorubicin-Induced Cardiotoxicity through the AKT/mTOR Signaling Pathway.
Jiao Y, Li Y, Zhang J, Zhang S, Zha Y, Wang J
Biomolecules 2022 Feb 12;12(2)
Biomolecules 2022 Feb 12;12(2)
A Second Near-Infrared Ru(II) Polypyridyl Complex for Synergistic Chemo-Photothermal Therapy.
Liu Y, Li Q, Gu M, Lu D, Xiong X, Zhang Z, Pan Y, Liao Y, Ding Q, Gong W, Chen DS, Guan M, Wu J, Tian Z, Deng H, Gu L, Hong X, Xiao Y
Journal of medicinal chemistry 2022 Feb 10;65(3):2225-2237
Journal of medicinal chemistry 2022 Feb 10;65(3):2225-2237
Design, synthesis and biological evaluation of novel 1,3,4,9-tetrahydropyrano[3,4-b]indoles as potential treatment of triple negative breast cancer by suppressing PI3K/AKT/mTOR pathway.
Qin J, Sun X, Ma Y, Cheng Y, Ma Q, Jing W, Qu S, Liu L
Bioorganic & medicinal chemistry 2022 Feb 1;55:116594
Bioorganic & medicinal chemistry 2022 Feb 1;55:116594
Genistein interferes with antitumor effects of cisplatin in an ovariectomized breast cancer xenograft tumor model.
Ma X, Yu X, Min J, Chen X, Liu R, Cui X, Cheng J, Xie M, Diel P, Hu X
Toxicology letters 2022 Feb 1;355:106-115
Toxicology letters 2022 Feb 1;355:106-115
Berberine inhibits gastric cancer development and progression by regulating the JAK2/STAT3 pathway and downregulating IL-6.
Xu M, Ren L, Fan J, Huang L, Zhou L, Li X, Ye X
Life sciences 2022 Feb 1;290:120266
Life sciences 2022 Feb 1;290:120266
Trimethylamine N-oxide promotes hyperoxaluria-induced calcium oxalate deposition and kidney injury by activating autophagy.
Dong F, Jiang S, Tang C, Wang X, Ren X, Wei Q, Tian J, Hu W, Guo J, Fu X, Liu L, Patzak A, Persson PB, Gao F, Lai EY, Zhao L
Free radical biology & medicine 2022 Feb 1;179:288-300
Free radical biology & medicine 2022 Feb 1;179:288-300
QiShenYiQi pill for myocardial collagen metabolism and apoptosis in rats of autoimmune cardiomyopathy.
Lv S, Zhang W, Yuan P, Lu C, Dong J, Zhang J
Pharmaceutical biology 2022 Dec;60(1):722-728
Pharmaceutical biology 2022 Dec;60(1):722-728
Cinobufagin induces acute promyelocytic leukaemia cell apoptosis and PML-RARA degradation in a caspase-dependent manner by inhibiting the β-catenin signalling pathway.
Bian Y, Xue M, Guo X, Jiang W, Zhao Y, Zhang Z, Wang X, Hu Y, Zhang Q, Dun W, Zhang L
Pharmaceutical biology 2022 Dec;60(1):1801-1811
Pharmaceutical biology 2022 Dec;60(1):1801-1811
Polyphyllin II induced apoptosis of NSCLC cells by inhibiting autophagy through the mTOR pathway.
Jiao Y, Xin M, Xu J, Xiang X, Li X, Jiang J, Jia X
Pharmaceutical biology 2022 Dec;60(1):1781-1789
Pharmaceutical biology 2022 Dec;60(1):1781-1789
Study on the biological mechanism of urolithin a on nasopharyngeal carcinoma in vitro.
Yang Y, Ren ZZ, Wei WJ, He ZL, Deng YL, Wang Z, Fan YC, Zhou J, Jiang LH
Pharmaceutical biology 2022 Dec;60(1):1566-1577
Pharmaceutical biology 2022 Dec;60(1):1566-1577
A metabolomic approach to study triptolide-induced ovarian damage in rats.
Zhou F, Zhong LL, Tan Y, Liu L, Pei G
Toxicology 2022 Dec;482:153351
Toxicology 2022 Dec;482:153351
Resveratrol inhibits the progression of premature senescence partially by regulating v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA) and sirtuin 1 (SIRT1).
He S, Zhou M, Zheng H, Wang Y, Wu S, Gao Y, Chen J
Renal failure 2022 Dec;44(1):171-183
Renal failure 2022 Dec;44(1):171-183
Cystathionine γ-lyase mediates cell proliferation, migration, and invasion of nasopharyngeal carcinoma.
Zhang Q, Gao Y, Zhang Y, Jing M, Wang D, Wang Y, Khattak S, Qi H, Cai C, Zhang J, Ngowi EE, Khan NH, Li T, Ji A, Jiang Q, Ji X, Li Y, Wu D
Oncogene 2022 Dec;41(49):5238-5252
Oncogene 2022 Dec;41(49):5238-5252
Involvement of the gut-brain axis in vascular depression via tryptophan metabolism: A benefit of short chain fatty acids.
Xiao W, Li J, Gao X, Yang H, Su J, Weng R, Gao Y, Ni W, Gu Y
Experimental neurology 2022 Dec;358:114225
Experimental neurology 2022 Dec;358:114225
c-Myc plays a critical role in the antileukemic activity of the Mcl-1-selective inhibitor AZD5991 in acute myeloid leukemia.
Liu S, Qiao X, Wu S, Gai Y, Su Y, Edwards H, Wang Y, Lin H, Taub JW, Wang G, Ge Y
Apoptosis : an international journal on programmed cell death 2022 Dec;27(11-12):913-928
Apoptosis : an international journal on programmed cell death 2022 Dec;27(11-12):913-928
Mild hypothermia ameliorates hepatic ischemia reperfusion injury by inducing RBM3 expression.
Xiao Q, Liu Y, Zhang X, Liu Z, Xiao J, Ye Q, Fu B
Apoptosis : an international journal on programmed cell death 2022 Dec;27(11-12):899-912
Apoptosis : an international journal on programmed cell death 2022 Dec;27(11-12):899-912
Alfalfa saponins inhibit oxidative stress-induced cell apoptosis through the MAPK signaling pathway.
Cui Y, Li F, Zhu X, Xu J, Muhammad A, Chen Y, Li D, Liu B, Wang C, Wang Z, Ma S, Liu X, Shi Y
Redox report : communications in free radical research 2022 Dec;27(1):1-8
Redox report : communications in free radical research 2022 Dec;27(1):1-8
Acteoside alleviates dextran sulphate sodium‑induced ulcerative colitis via regulation of the HO‑1/HMGB1 signaling pathway.
Guo W, Wang X, Liu F, Chen S, Wang S, Zhang Q, Yuan L, Du S
Molecular medicine reports 2022 Dec;26(6)
Molecular medicine reports 2022 Dec;26(6)
FBXL6 depletion restrains clear cell renal cell carcinoma progression.
Yu Y, Yao W, Wang T, Xue W, Meng Y, Cai L, Jian W, Yu Y, Zhang C
Translational oncology 2022 Dec;26:101550
Translational oncology 2022 Dec;26:101550
Melatonin alleviates arginine vasopressin-induced cardiomyocyte apoptosis via increasing Mst1-Nrf2 pathway activity to reduce oxidative stress.
Chen S, Li Y, Fu S, Li Y, Wang C, Sun P, Li H, Tian J, Du GQ
Biochemical pharmacology 2022 Dec;206:115265
Biochemical pharmacology 2022 Dec;206:115265
Tumor-targeted dual-starvation therapy based on redox-responsive micelle nanosystem with co-loaded LND and BPTES.
Fu Z, Du H, Meng S, Yao M, Zhao P, Li X, Zheng X, Yuan Z, Yang H, Cai K, Dai L
Materials today. Bio 2022 Dec;16:100449
Materials today. Bio 2022 Dec;16:100449
Stilbene B10 induces apoptosis and tumor suppression in lymphoid Raji cells by BTK-mediated regulation of the KRAS/HDAC1/EP300/PEBP1 axis.
Varier KM, Dan G, Liu W, Wu G, Xiao C, Lei H, Ling T, Jiang Y, Chen Y, Ben-David Y, Li Y, Zhang N, Gajendran B, Shen X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Dec;156:113887
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Dec;156:113887
The transcription factor KLF14 attenuates LPS-induced acute lung injury by ameliorating apoptosis of alveolar epithelial cells in mice.
Liu L, Yuan Y, Zhou Y, Yao L, Li J, Chen F
Molecular immunology 2022 Dec;152:67-77
Molecular immunology 2022 Dec;152:67-77
Inhibition of cell proliferation by Tas of foamy viruses through cell cycle arrest or apoptosis underlines the different mechanisms of virus-host interactions.
Jie W, Rui-Fen Z, Zhong-Xiang H, Yan W, Wei-Na L, Yong-Ping M, Jing S, Jing-Yi C, Wan-Hong L, Xiao-Hua H, Zhi L, Yan S
Virulence 2022 Dec;13(1):342-354
Virulence 2022 Dec;13(1):342-354
Artemisitene suppresses rheumatoid arthritis progression via modulating METTL3-mediated N6-methyladenosine modification of ICAM2 mRNA in fibroblast-like synoviocytes.
Chen J, Lin X, He J, Liu D, He L, Zhang M, Luan H, Hu Y, Tao C, Wang Q
Clinical and translational medicine 2022 Dec;12(12):e1148
Clinical and translational medicine 2022 Dec;12(12):e1148
Isolongifolene alleviates liver ischemia/reperfusion injury by regulating AMPK-PGC1α signaling pathway-mediated inflammation, apoptosis, and oxidative stress.
Li J, Li J, Fang H, Yang H, Wu T, Shi X, Pang C
International immunopharmacology 2022 Dec;113(Pt A):109185
International immunopharmacology 2022 Dec;113(Pt A):109185
Effects of betaine on viability, apoptosis, function protein expression and oxidative status in heat-stressed IEC-6 cells.
Sun S, Yin Q, Li B, Deng Y, Li J, Xiong Y, Shaojun H
Journal of thermal biology 2022 Dec;110:103348
Journal of thermal biology 2022 Dec;110:103348
Targeting CRL4 suppresses chemoresistant ovarian cancer growth by inducing mitophagy.
Meng Y, Qiu L, Zeng X, Hu X, Zhang Y, Wan X, Mao X, Wu J, Xu Y, Xiong Q, Chen Z, Zhang B, Han J
Signal transduction and targeted therapy 2022 Dec 9;7(1):388
Signal transduction and targeted therapy 2022 Dec 9;7(1):388
Circ-CREBBP inhibits sperm apoptosis via the PI3K-Akt signaling pathway by sponging miR-10384 and miR-143-3p.
Ding N, Zhang Y, Huang M, Liu J, Wang C, Zhang C, Cao J, Zhang Q, Jiang L
Communications biology 2022 Dec 7;5(1):1339
Communications biology 2022 Dec 7;5(1):1339
Resveratrol inhibits proliferation and induces apoptosis via the Hippo/YAP pathway in human colon cancer cells.
Qin X, Luo H, Deng Y, Yao X, Zhang J, He B
Biochemical and biophysical research communications 2022 Dec 25;636(Pt 1):197-204
Biochemical and biophysical research communications 2022 Dec 25;636(Pt 1):197-204
Inhibitory effect of calycosin on breast cancer cell progression through downregulating lncRNA HOTAIR and downstream targets: HuR and IGF2BP1.
Li Y, Miao H, Wei W, Tian J, Chen J
Acta biochimica et biophysica Sinica 2022 Dec 25;55(2):225-236
Acta biochimica et biophysica Sinica 2022 Dec 25;55(2):225-236
microRNA-338-3p suppresses lipopolysaccharide-induced inflammatory response in HK-2 cells.
Wang J, Li G, Lin M, Lin S, Wu L
BMC molecular and cell biology 2022 Dec 23;23(1):60
BMC molecular and cell biology 2022 Dec 23;23(1):60
Multi-specific niflumic acid platinum(IV) complexes displaying potent antitumor activities by improving immunity and suppressing angiogenesis besides causing DNA damage.
Li L, Zhang M, Jia D, Liu Z, Zhang N, Sun B, Wang Z, Liu M, Wang Q
Dalton transactions (Cambridge, England : 2003) 2022 Dec 20;52(1):147-158
Dalton transactions (Cambridge, England : 2003) 2022 Dec 20;52(1):147-158
Platycodon grandiflorus Polysaccharides Alleviate Cr(VI)-Induced Apoptosis in DF-1 Cells via ROS-Drp1 Signal Pathway.
Zhang Z, Zheng P, Qi C, Cui Y, Qi Y, Xue K, Yan G, Liu J
Life (Basel, Switzerland) 2022 Dec 19;12(12)
Life (Basel, Switzerland) 2022 Dec 19;12(12)
Inactivation of Yes-Associated Protein Mediates Trophoblast Dysfunction: A New Mechanism of Pregnancy Loss Associated with Anti-Phospholipid Antibodies?
Huang Z, Tang Z, Guan H, Leung W, Wang L, Xia H, Zhang W
Biomedicines 2022 Dec 19;10(12)
Biomedicines 2022 Dec 19;10(12)
Inhibition of TIGAR Increases Exogenous p53 and Cisplatin Combination Sensitivity in Lung Cancer Cells by Regulating Glycolytic Flux.
Fu J, Yu S, Zhao X, Zhang C, Shen L, Liu Y, Yu H
International journal of molecular sciences 2022 Dec 16;23(24)
International journal of molecular sciences 2022 Dec 16;23(24)
Thrombus Inhibition and Neuroprotection for Ischemic Stroke Treatment through Platelet Regulation and ROS Scavenging.
Ye H, Ma Z, Liu L, Zhang T, Han Q, Xiang Z, Xia Y, Ke Y, Guan X, Shi Q, Ataullakhanov FI, Panteleev M
ChemMedChem 2022 Dec 16;17(24):e202200317
ChemMedChem 2022 Dec 16;17(24):e202200317
Anti-Tumor Effects of Engineered VNP20009-Abvec-Igκ-mPD-1 Strain in Melanoma Mice via Combining the Oncolytic Therapy and Immunotherapy.
Zhou DX, Wang XH, Xu X, Chen WJ, Wei J, Chen TT, Wei H
Pharmaceutics 2022 Dec 13;14(12)
Pharmaceutics 2022 Dec 13;14(12)
FUT2 Facilitates Autophagy and Suppresses Apoptosis via p53 and JNK Signaling in Lung Adenocarcinoma Cells.
Zhang Y, Yao E, Liu Y, Zhang Y, Ding M, Liu J, Chen X, Fan S
Cells 2022 Dec 13;11(24)
Cells 2022 Dec 13;11(24)
Adipose-Derived Mesenchymal Stem Cells Alleviate Hypertrophic Scar by Inhibiting Bioactivity and Inducing Apoptosis in Hypertrophic Scar Fibroblasts.
Li S, Yang J, Sun J, Chen M
Cells 2022 Dec 12;11(24)
Cells 2022 Dec 12;11(24)
Macrophages regulate vascular smooth muscle cell function during atherosclerosis progression through IL-1β/STAT3 signaling.
Xue Y, Luo M, Hu X, Li X, Shen J, Zhu W, Huang L, Hu Y, Guo Y, Liu L, Wang L, Luo S
Communications biology 2022 Dec 1;5(1):1316
Communications biology 2022 Dec 1;5(1):1316
Adiponectin/AdiopR1 signaling prevents mitochondrial dysfunction and oxidative injury after traumatic brain injury in a SIRT3 dependent manner.
Zhang S, Wu X, Wang J, Shi Y, Hu Q, Cui W, Bai H, Zhou J, Du Y, Han L, Li L, Feng D, Ge S, Qu Y
Redox biology 2022 Aug;54:102390
Redox biology 2022 Aug;54:102390
Effect of low energy shock wave on testicular microenvironment homeostasis in rats.
Xing J, Yu G, Xiang Y, Xu H, Liu Z, Bai Z
Ecotoxicology and environmental safety 2022 Aug;241:113710
Ecotoxicology and environmental safety 2022 Aug;241:113710
Identification and verification of the role of crucial genes through which methionine restriction inhibits the progression of colon cancer cells.
Zhou L, Chen Z, Liu C
Oncology letters 2022 Aug;24(2):274
Oncology letters 2022 Aug;24(2):274
Nav1.6 promotes the progression of human follicular thyroid carcinoma cells via JAK-STAT signaling pathway.
Li H, Liu J, Fan N, Wang H, Thomas AM, Yan Q, Li S, Qin H
Pathology, research and practice 2022 Aug;236:153984
Pathology, research and practice 2022 Aug;236:153984
Protective Effects of Three Flavonoids from Dendrobium huoshanense Flowers on Alcohol-Induced Hepatocyte Injury via Activating Nrf2 and Inhibiting NF-κB Pathways.
Li QM, Yang XR, Zha XQ, Pan LH, Zang DD, Zhang FY, Luo JP
Chemistry & biodiversity 2022 Aug;19(8):e202200471
Chemistry & biodiversity 2022 Aug;19(8):e202200471
The miR-410-5p /ITGA6 axis participates in the pathogenesis of recurrent abortion by regulating the biological function of trophoblast.
Wu S, Liu H, Zhou M, Shang Y, Luo L, Chen J, Yang J
Journal of reproductive immunology 2022 Aug;152:103647
Journal of reproductive immunology 2022 Aug;152:103647
CD13 downregulation mediated by ubenimex inhibits autophagy to overcome 5-FU resistance by disturbing the EMP3/FAK/NF-κB pathway in gastric cancer cells.
Xiu T, Guo Q, Jing F, Shi Y, Jing F
Translational cancer research 2022 Aug;11(8):2487-2500
Translational cancer research 2022 Aug;11(8):2487-2500
Phosphorylated STYK1 restrains the inhibitory role of EGFR in autophagy initiation and EGFR-TKIs sensitivity.
Zhou C, Dong X, Wang M, Qian X, Hu M, Liang K, Liang Y, Zhang R, Huang Y, Lyu H, Xiao S, Tang Y, Ali DW, Michalak M, Chen XZ, Tang J
Cell insight 2022 Aug;1(4):100045
Cell insight 2022 Aug;1(4):100045
The Relationship between Procyanidin Structure and Their Protective Effect in a Parkinson's Disease Model.
Chen J, Chen Y, Zheng Y, Zhao J, Yu H, Zhu J
Molecules (Basel, Switzerland) 2022 Aug 6;27(15)
Molecules (Basel, Switzerland) 2022 Aug 6;27(15)
Design, synthesis, and in vitro protective effect evaluation of α-carboline derivatives against H(2)O(2)-induced cardiomyocyte injury.
Zhang RH, Yang D, Liao XM, Zhang H, Chen GQ, Zhang WL, Wang YC, Wang C, Liao SG, Zhou M, Wang YL, Li YJ
European journal of medicinal chemistry 2022 Aug 5;238:114469
European journal of medicinal chemistry 2022 Aug 5;238:114469
Discovery of precision targeting EZH2 degraders for triple-negative breast cancer.
Wang C, Chen X, Liu X, Lu D, Li S, Qu L, Yin F, Luo H, Zhang Y, Luo Z, Cui N, Kong L, Wang X
European journal of medicinal chemistry 2022 Aug 5;238:114462
European journal of medicinal chemistry 2022 Aug 5;238:114462
Hyaluronic Acid Oligosaccharide Derivatives Alleviate Lipopolysaccharide-Induced Inflammation in ATDC5 Cells by Multiple Mechanisms.
Huang H, Ding X, Xing D, Lin J, Li Z, Lin J
Molecules (Basel, Switzerland) 2022 Aug 31;27(17)
Molecules (Basel, Switzerland) 2022 Aug 31;27(17)
Inhibition of autophagy potentiates the cytotoxicity of the irreversible FGFR1-4 inhibitor FIIN-2 on lung adenocarcinoma.
Jia X, Xin M, Xu J, Xiang X, Li X, Jiao Y, Wang L, Jiang J, Pang F, Zhang X, Zhang J
Cell death & disease 2022 Aug 30;13(8):750
Cell death & disease 2022 Aug 30;13(8):750
Assembly of Celastrol to Zeolitic Imidazolate Framework-8 by Coordination as a Novel Drug Delivery Strategy for Cancer Therapy.
Wang N, Li Y, He F, Liu S, Liu Y, Peng J, Liu J, Yu C, Wang S
Pharmaceuticals (Basel, Switzerland) 2022 Aug 29;15(9)
Pharmaceuticals (Basel, Switzerland) 2022 Aug 29;15(9)
Non-Esterified Fatty Acid Induces ER Stress-Mediated Apoptosis via ROS/MAPK Signaling Pathway in Bovine Mammary Epithelial Cells.
Yan Y, Huang J, Huan C, Li L, Li C
Metabolites 2022 Aug 27;12(9)
Metabolites 2022 Aug 27;12(9)
The microRNA-10b-Bim axis promotes cancer progression through activating autophagy in oral squamous cell carcinoma.
Li S, Gao L, Liu J, Guo C, Zheng J, Zhi K, Ren W
Cell death discovery 2022 Aug 25;8(1):373
Cell death discovery 2022 Aug 25;8(1):373
Development of a series of flurbiprofen and zaltoprofen platinum(IV) complexes with anti-metastasis competence targeting COX-2, PD-L1 and DNA.
Li Z, Li L, Zhao W, Sun B, Liu Z, Liu M, Han J, Wang Z, Li D, Wang Q
Dalton transactions (Cambridge, England : 2003) 2022 Aug 23;51(33):12604-12619
Dalton transactions (Cambridge, England : 2003) 2022 Aug 23;51(33):12604-12619
Regulation of the sensitivity of hepatocarcinoma cells by ORMDL3, to sorafenib by autophagy.
Sun Y, Guan X, Zhang T, Li Y, Shi H, Chitakunye AT, Hong H, Zhang S, Zhu Q, Cai L
Medical oncology (Northwood, London, England) 2022 Aug 16;39(11):159
Medical oncology (Northwood, London, England) 2022 Aug 16;39(11):159
12/15-Lipoxygenase Regulation of Diabetic Cognitive Dysfunction Is Determined by Interfering with Inflammation and Cell Apoptosis.
Chen Q, Zheng Q, Yang Y, Luo Y, Wang H, Li H, Yang L, Hu C, Zhang J, Li Y, Xia H, Chen Z, Ma J, Tian X, Yang J
International journal of molecular sciences 2022 Aug 12;23(16)
International journal of molecular sciences 2022 Aug 12;23(16)
Sparstolonin B inhibits pancreatic adenocarcinoma through the NF-κB signaling pathway.
Lyu Y, Duan B, Liu Z, Yang F, Chen C, Jiang X, Liu X
Experimental cell research 2022 Aug 1;417(1):113214
Experimental cell research 2022 Aug 1;417(1):113214
Acetyl CoA synthase 2 potentiates ATG5-induced autophagy against neuronal apoptosis after subarachnoid hemorrhage.
He W, Zhou X, Wu Q, Zhou L, Zhang Z, Zhang R, Deng C, Zhang X
Journal of molecular histology 2022 Apr;53(2):511-521
Journal of molecular histology 2022 Apr;53(2):511-521
Copper induces oxidative stress and apoptosis of hippocampal neuron via pCREB/BDNF/ and Nrf2/HO-1/NQO1 pathway.
Lu Q, Zhang Y, Zhao C, Zhang H, Pu Y, Yin L
Journal of applied toxicology : JAT 2022 Apr;42(4):694-705
Journal of applied toxicology : JAT 2022 Apr;42(4):694-705
MiR-125b enhances doxorubicin-induced cardiotoxicity by suppressing the nucleus-cytoplasmic translocation of YAP via targeting STARD13.
Jin X, Yu W, Ye P
Environmental toxicology 2022 Apr;37(4):730-740
Environmental toxicology 2022 Apr;37(4):730-740
TIMP2 mediates endoplasmic reticulum stress contributing to sepsis-induced acute kidney injury.
Jiang N, Huang R, Zhang J, Xu D, Li T, Sun Z, Su L, Peng Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Apr;36(4):e22228
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Apr;36(4):e22228
Andrographolide Inhibits Proliferation and Promotes Apoptosis in Bladder Cancer Cells by Interfering with NF- κ B and PI3K/AKT Signaling In Vitro and In Vivo.
Xuan L, Hu JH, Bi R, Liu SQ, Wang CX
Chinese journal of integrative medicine 2022 Apr;28(4):349-356
Chinese journal of integrative medicine 2022 Apr;28(4):349-356
Pharmacological inhibition of CDK7 by THZ1 impairs tumor growth in p53-mutated HNSCC.
Ge H, Yao Y, Jiang Y, Wu X, Wang Y
Oral diseases 2022 Apr;28(3):611-620
Oral diseases 2022 Apr;28(3):611-620
DEC1 promotes progression of Helicobacter pylori-positive gastric cancer by regulating Akt/NF-κB pathway.
Jia Y, Liu Y, Zhu J, Liu L, Ma X, Liu D, Han S, Zhang L, Ling ZQ, Wang Y
Journal of cellular and molecular medicine 2022 Apr;26(7):1943-1954
Journal of cellular and molecular medicine 2022 Apr;26(7):1943-1954
Tetrastigma hemsleyanum Diels et Gilg ameliorates lipopolysaccharide induced sepsis via repairing the intestinal mucosal barrier.
Zhan L, Pu J, Zheng J, Hang S, Pang L, Dai M, Ji C
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Apr;148:112741
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Apr;148:112741
Guizhi Fuling pill attenuates liver fibrosis in vitro and in vivo via inhibiting TGF-β1/Smad2/3 and activating IFN-γ/Smad7 signaling pathways.
Liu Z, Xu B, Ding Y, Ding X, Yang Z
Bioengineered 2022 Apr;13(4):9357-9368
Bioengineered 2022 Apr;13(4):9357-9368
TIM-1 promotes proliferation and metastasis, and inhibits apoptosis, in cervical cancer through the PI3K/AKT/p53 pathway.
Chen L, Qing J, Xiao Y, Huang X, Chi Y, Chen Z
BMC cancer 2022 Apr 7;22(1):370
BMC cancer 2022 Apr 7;22(1):370
Protective effects of 5(S)-5-carboxystrictosidine on myocardial ischemia-reperfusion injury through activation of mitochondrial KATP channels.
Han Y, Li C, Zhang P, Yang X, Min J, Wu Q, Xie Y, Jin D, Wang Z, Shao F, Quan H
European journal of pharmacology 2022 Apr 5;920:174811
European journal of pharmacology 2022 Apr 5;920:174811
Targeting IL8 as a sequential therapy strategy to overcome chemotherapy resistance in advanced gastric cancer.
Jiang H, Cui J, Chu H, Xu T, Xie M, Jing X, Xu J, Zhou J, Shu Y
Cell death discovery 2022 Apr 29;8(1):235
Cell death discovery 2022 Apr 29;8(1):235
Preventive effects of the AMPA receptor potentiator LY450108 in an LPS-induced depressive mouse model.
Yao H, Guo W, Suo L, Li G, Wang Y, Chen Y, Sun Y, Ding R
Behavioural brain research 2022 Apr 29;424:113813
Behavioural brain research 2022 Apr 29;424:113813
Map of Enteropathogenic Escherichia coli Targets Mitochondria and Triggers DRP-1-Mediated Mitochondrial Fission and Cell Apoptosis in Bovine Mastitis.
Li Y, Zhu Y, Chu B, Liu N, Chen S, Wang J, Zou Y
International journal of molecular sciences 2022 Apr 28;23(9)
International journal of molecular sciences 2022 Apr 28;23(9)
Brusatol inhibits the growth of renal cell carcinoma by regulating the PTEN/PI3K/AKT pathway.
Wang T, Chen Z, Chen H, Yu X, Wang L, Liu X
Journal of ethnopharmacology 2022 Apr 24;288:115020
Journal of ethnopharmacology 2022 Apr 24;288:115020
Oxidative Stress-Induced TRPV2 Expression Increase Is Involved in Diabetic Cataracts and Apoptosis of Lens Epithelial Cells in a High-Glucose Environment.
Chen L, Chen Y, Ding W, Zhan T, Zhu J, Zhang L, Wang H, Shen B, Wang Y
Cells 2022 Apr 2;11(7)
Cells 2022 Apr 2;11(7)
The microbiota-gut-brain axis participates in chronic cerebral hypoperfusion by disrupting the metabolism of short-chain fatty acids.
Xiao W, Su J, Gao X, Yang H, Weng R, Ni W, Gu Y
Microbiome 2022 Apr 17;10(1):62
Microbiome 2022 Apr 17;10(1):62
NaAsO(2) decreases GSH synthesis by inhibiting GCLC and induces apoptosis through Hela cell mitochondrial damage, mediating the activation of the NF-κB/miR-21 signaling pathway.
Ran S, Gao X, Ma M, Zhang J, Li S, Zhang M, Li S
Ecotoxicology and environmental safety 2022 Apr 1;234:113380
Ecotoxicology and environmental safety 2022 Apr 1;234:113380
Chaperone-mediated autophagy plays an important role in regulating retinal progenitor cell homeostasis.
Jin C, Ou Q, Chen J, Wang T, Zhang J, Wang Z, Wang Y, Tian H, Xu JY, Gao F, Wang J, Li J, Lu L, Xu GT
Stem cell research & therapy 2022 Apr 1;13(1):136
Stem cell research & therapy 2022 Apr 1;13(1):136
Comprehensive analysis of abnormal expression, prognostic value and oncogenic role of the hub gene FN1 in pancreatic ductal adenocarcinoma via bioinformatic analysis and in vitro experiments.
Lei X, Chen G, Li J, Wen W, Gong J, Fu J
PeerJ 2021;9:e12141
PeerJ 2021;9:e12141
Identification of KIF4A as a pan-cancer diagnostic and prognostic biomarker via bioinformatics analysis and validation in osteosarcoma cell lines.
Pan J, Lei X, Mao X
PeerJ 2021;9:e11455
PeerJ 2021;9:e11455
Inhibitory effect and mechanism of action (MOA) of hirsutine on the proliferation of T-cell leukemia Jurkat clone E6-1 cells.
Meng J, Su R, Wang L, Yuan B, Li L
PeerJ 2021;9:e10692
PeerJ 2021;9:e10692
The GDF11 Promotes Nerve Regeneration After Sciatic Nerve Injury in Adult Rats by Promoting Axon Growth and Inhibiting Neuronal Apoptosis.
Lin J, Shi J, Min X, Chen S, Zhao Y, Zhang Y, Cheng L
Frontiers in bioengineering and biotechnology 2021;9:803052
Frontiers in bioengineering and biotechnology 2021;9:803052
Apigenin Alleviates Intervertebral Disc Degeneration via Restoring Autophagy Flux in Nucleus Pulposus Cells.
Xie C, Shi Y, Chen Z, Zhou X, Luo P, Hong C, Tian N, Wu Y, Zhou Y, Lin Y, Dou H, Wu A, Huang Q, Zhang X, Wang X
Frontiers in cell and developmental biology 2021;9:787278
Frontiers in cell and developmental biology 2021;9:787278
Hypoxia Activates Notch4 via ERK/JNK/P38 MAPK Signaling Pathways to Promote Lung Adenocarcinoma Progression and Metastasis.
Li X, Cao X, Zhao H, Guo M, Fang X, Li K, Qin L, He Y, Liu X
Frontiers in cell and developmental biology 2021;9:780121
Frontiers in cell and developmental biology 2021;9:780121
LncRNA FEZF1-AS1 Promotes Multi-Drug Resistance of Gastric Cancer Cells via Upregulating ATG5.
Gui Z, Zhao Z, Sun Q, Shao G, Huang J, Zhao W, Kuang Y
Frontiers in cell and developmental biology 2021;9:749129
Frontiers in cell and developmental biology 2021;9:749129
Syndromic Deafness Gene ATP6V1B2 Controls Degeneration of Spiral Ganglion Neurons Through Modulating Proton Flux.
Qiu S, Zhao W, Gao X, Li D, Wang W, Gao B, Han W, Yang S, Dai P, Cao P, Yuan Y
Frontiers in cell and developmental biology 2021;9:742714
Frontiers in cell and developmental biology 2021;9:742714
The Regulatory Role of GBF1 on Osteoclast Activation Through EIF2a Mediated ER Stress and Novel Marker FAM129A Induction.
Wen C, Zhou Y, Xu Y, Tan H, Pang C, Liu H, Liu K, Wei L, Luo H, Qin T, He C, Liu C, Zhou C
Frontiers in cell and developmental biology 2021;9:706768
Frontiers in cell and developmental biology 2021;9:706768
Apatinib Suppresses Gastric Cancer Stem Cells Properties by Inhibiting the Sonic Hedgehog Pathway.
Cao W, Li Y, Sun H, Yang C, Zhu J, Xie C, Li X, Wu J, Geng S, Wang L, Sun L, Geng G, Han H, Zhong C
Frontiers in cell and developmental biology 2021;9:679806
Frontiers in cell and developmental biology 2021;9:679806
Ufbp1, a Key Player of Ufm1 Conjugation System, Protects Against Ketosis-Induced Liver Injury via Suppressing Smad3 Activation.
Chen F, Sheng L, Xu C, Li J, Ali I, Li H, Cai Y
Frontiers in cell and developmental biology 2021;9:676789
Frontiers in cell and developmental biology 2021;9:676789
NLGN3 Upregulates Expression of ADAM10 to Promote the Cleavage of NLGN3 via Activating the LYN Pathway in Human Gliomas.
Dang NN, Li XB, Zhang M, Han C, Fan XY, Huang SH
Frontiers in cell and developmental biology 2021;9:662763
Frontiers in cell and developmental biology 2021;9:662763
Rutaecarpine Inhibits Doxorubicin-Induced Oxidative Stress and Apoptosis by Activating AKT Signaling Pathway.
Liao ZQ, Jiang YN, Su ZL, Bi HL, Li JT, Li CL, Yang XL, Zhang Y, Xie X
Frontiers in cardiovascular medicine 2021;8:809689
Frontiers in cardiovascular medicine 2021;8:809689
Auranofin and ICG-001 Emerge Synergistic Anti-tumor Effect on Canine Breast Cancer by Inducing Apoptosis via Mitochondrial Pathway.
Lin Z, Lin Z, Zhao Y, Cheng N, Zhang D, Lin J, Zhang H, Lin D
Frontiers in veterinary science 2021;8:772687
Frontiers in veterinary science 2021;8:772687
Maslinic Acid Attenuates Ischemia/Reperfusion Injury-Induced Myocardial Inflammation and Apoptosis by Regulating HMGB1-TLR4 Axis.
Li Q, Xu M, Li Z, Li T, Wang Y, Chen Q, Wang Y, Feng J, Yin X, Lu C
Frontiers in cardiovascular medicine 2021;8:768947
Frontiers in cardiovascular medicine 2021;8:768947
Citric Acid Promoting B Lymphocyte Differentiation and Anti-epithelial Cells Apoptosis Mediate the Protective Effects of Hermetia illucens Feed in ETEC Induced Piglets Diarrhea.
Liu M, Yuan B, Jin X, Zhu M, Xu H, Xie G, Wang Z, Zhang X, Xu Z, Li B, Huang Y, Lv Y, Wang W
Frontiers in veterinary science 2021;8:751861
Frontiers in veterinary science 2021;8:751861
The Role of TRPC6 in Renal Ischemia/Reperfusion and Cellular Hypoxia/Reoxygenation Injuries.
Hou X, Huang M, Zeng X, Zhang Y, Sun A, Wu Q, Zhu L, Zhao H, Liao Y
Frontiers in molecular biosciences 2021;8:698975
Frontiers in molecular biosciences 2021;8:698975
Traditional Chinese Medication Qiliqiangxin Attenuates Diabetic Cardiomyopathy via Activating PPARγ.
Wu X, Zhang T, Lyu P, Chen M, Ni G, Cheng H, Xu G, Li X, Wang L, Shang H
Frontiers in cardiovascular medicine 2021;8:698056
Frontiers in cardiovascular medicine 2021;8:698056
Plasma Purification Treatment Relieves the Damage of Hyperlipidemia to PBMCs.
Zhang XM, Gu YH, Deng H, Xu ZQ, Zhong ZY, Lyu XJ, Jin HM, Yang XH
Frontiers in cardiovascular medicine 2021;8:691336
Frontiers in cardiovascular medicine 2021;8:691336
Sinomenine Suppresses Development of Hepatocellular Carcinoma Cells via Inhibiting MARCH1 and AMPK/STAT3 Signaling Pathway.
Yang W, Feng Q, Li M, Su J, Wang P, Wang X, Yin Y, Wang X, Zhao M
Frontiers in molecular biosciences 2021;8:684262
Frontiers in molecular biosciences 2021;8:684262
Lactobacillus acidophilus ATCC 4356 Alleviates Renal Ischemia-Reperfusion Injury Through Antioxidant Stress and Anti-inflammatory Responses and Improves Intestinal Microbial Distribution.
Zhang P, Han X, Zhang X, Zhu X
Frontiers in nutrition 2021;8:667695
Frontiers in nutrition 2021;8:667695
Exosomal MicroRNA-181a Derived From Mesenchymal Stem Cells Improves Gut Microbiota Composition, Barrier Function, and Inflammatory Status in an Experimental Colitis Model.
Gu L, Ren F, Fang X, Yuan L, Liu G, Wang S
Frontiers in medicine 2021;8:660614
Frontiers in medicine 2021;8:660614
Pilose Antler Peptide-3.2KD Ameliorates Adriamycin-Induced Myocardial Injury Through TGF-β/SMAD Signaling Pathway.
Xu Y, Qu X, Zhou J, Lv G, Han D, Liu J, Liu Y, Chen Y, Qu P, Huang X
Frontiers in cardiovascular medicine 2021;8:659643
Frontiers in cardiovascular medicine 2021;8:659643
Hengshun Aromatic Vinegar Ameliorates Vascular Endothelial Injury via Regulating PKCζ-Mediated Oxidative Stress and Apoptosis.
Li X, Gao M, Zhu S, Yin L, Zhang B, Qi Y, Zhao Y, Yu Y, Xu L
Frontiers in nutrition 2021;8:635232
Frontiers in nutrition 2021;8:635232
Liraglutide Protects Nucleus Pulposus Cells Against High-Glucose Induced Apoptosis by Activating PI3K/Akt/ mTOR/Caspase-3 and PI3K/Akt/GSK3β/Caspase-3 Signaling Pathways.
Yao M, Zhang J, Li Z, Bai X, Ma J, Li Y
Frontiers in medicine 2021;8:630962
Frontiers in medicine 2021;8:630962
Gentiopicroside Inhibits Cell Growth and Migration on Cervical Cancer via the Reciprocal MAPK/Akt Signaling Pathways.
Hu Z, Wang H, Fu Y, Ma K, Ma X, Wang J
Nutrition and cancer 2021;73(8):1459-1470
Nutrition and cancer 2021;73(8):1459-1470
Resveratrol Inhibition of Renal Cancer Stem Cell Characteristics and Modulation of the Sonic Hedgehog Pathway.
Sun H, Zhang T, Liu R, Cao W, Zhang Z, Liu Z, Qian W, Wang D, Yu D, Zhong C
Nutrition and cancer 2021;73(7):1157-1167
Nutrition and cancer 2021;73(7):1157-1167
EphA2 overexpression reduces H2O2-induced damage of lens epithelial cells.
Ji Q, Liu J, Wang G, Liu L, Zhong J
Genetics and molecular biology 2021;44(3):e20200414
Genetics and molecular biology 2021;44(3):e20200414
Shen-fu injection alleviates acute renal injury by reducing cytokine levels and modulating apoptosis in a porcine hemorrhagic shock model.
Yuan W, Wu J, Zhang Q, Liang Y, Zhang M, Qin H, Li CS
Acta cirurgica brasileira 2021;36(4):e360405
Acta cirurgica brasileira 2021;36(4):e360405
H2S improves doxorubicin-induced myocardial fibrosis by inhibiting oxidative stress and apoptosis via Keap1-Nrf2.
Li Y, Chandra TP, Song X, Nie L, Liu M, Yi J, Zheng X, Chu C, Yang J
Technology and health care : official journal of the European Society for Engineering and Medicine 2021;29(S1):195-209
Technology and health care : official journal of the European Society for Engineering and Medicine 2021;29(S1):195-209
Lipidomic Alterations and PPARα Activation Induced by Resveratrol Lead to Reduction in Lesion Size in Endometriosis Models.
Chen Z, Wang C, Lin C, Zhang L, Zheng H, Zhou Y, Li X, Li C, Zhang X, Yang X, Guan M, Xi Y
Oxidative medicine and cellular longevity 2021;2021:9979953
Oxidative medicine and cellular longevity 2021;2021:9979953
Long Noncoding RNA HCG9 Promotes Osteosarcoma Progression through RAD51 by Acting as a ceRNA of miR-34b-3p.
Wang L, Li S, Qi L, Ling L
Mediators of inflammation 2021;2021:9978882
Mediators of inflammation 2021;2021:9978882
Huxie Huaji Ointment Induced Apoptosis of Liver Cancer Cells In Vivo and In Vitro by Activating the Mitochondrial Pathway.
Cai Y, Du Q, Deng TH, Shen BB, Peng YM, Zeng PH, Yu SR
Evidence-based complementary and alternative medicine : eCAM 2021;2021:9922059
Evidence-based complementary and alternative medicine : eCAM 2021;2021:9922059
Escin Sodium Improves the Prognosis of Acute Pancreatitis via Promoting Cell Apoptosis by Suppression of the ERK/STAT3 Signaling Pathway.
Zhang Q, Zhao C, Zhang L, Sun K, Yu L, Wang X, Ren L, Zhang N, Chen C, Liu J, Wang H, Tian H
Oxidative medicine and cellular longevity 2021;2021:9921839
Oxidative medicine and cellular longevity 2021;2021:9921839
PICK1 Deficiency Exacerbates Sepsis-Associated Acute Kidney Injury.
Dou Q, Tong H, Yang Y, Zhang H, Gan H
BioMed research international 2021;2021:9884297
BioMed research international 2021;2021:9884297
Mechanosensitive Ion Channel Piezo1 Activated by Matrix Stiffness Regulates Oxidative Stress-Induced Senescence and Apoptosis in Human Intervertebral Disc Degeneration.
Wang B, Ke W, Wang K, Li G, Ma L, Lu S, Xiang Q, Liao Z, Luo R, Song Y, Hua W, Wu X, Zhang Y, Zeng X, Yang C
Oxidative medicine and cellular longevity 2021;2021:8884922
Oxidative medicine and cellular longevity 2021;2021:8884922
Melatonin Attenuates Diabetic Myocardial Microvascular Injury through Activating the AMPK/SIRT1 Signaling Pathway.
Wang B, Li J, Bao M, Chen R, Li H, Lu B, Chen M, Huang D, Zhang Y, Gao F, Shi G
Oxidative medicine and cellular longevity 2021;2021:8882130
Oxidative medicine and cellular longevity 2021;2021:8882130
Tetrandrine Ameliorates Myocardial Ischemia Reperfusion Injury through miR-202-5p/TRPV2.
Zhao W, Wu Y, Ye F, Huang S, Chen H, Zhou R, Jiang W
BioMed research international 2021;2021:8870674
BioMed research international 2021;2021:8870674
Sodium Houttuyfonate Ameliorates β-amyloid(1-42)-Induced Memory Impairment and Neuroinflammation through Inhibiting the NLRP3/GSDMD Pathway in Alzheimer's Disease.
Zhao Y, Tian Y, Feng T
Mediators of inflammation 2021;2021:8817698
Mediators of inflammation 2021;2021:8817698
Effects of Noninvasive Low-Intensity Focus Ultrasound Neuromodulation on Spinal Cord Neurocircuits In Vivo.
Liao YH, Chen MX, Chen SC, Luo KX, Wang B, Liu Y, Ao LJ
Evidence-based complementary and alternative medicine : eCAM 2021;2021:8534466
Evidence-based complementary and alternative medicine : eCAM 2021;2021:8534466
Catalpol-Induced AMPK Activation Alleviates Cisplatin-Induced Nephrotoxicity through the Mitochondrial-Dependent Pathway without Compromising Its Anticancer Properties.
Zhang J, Zhao T, Wang C, Meng Q, Huo X, Wang C, Sun P, Sun H, Ma X, Wu J, Liu K
Oxidative medicine and cellular longevity 2021;2021:7467156
Oxidative medicine and cellular longevity 2021;2021:7467156
Tilianin Ameliorates Cognitive Dysfunction and Neuronal Damage in Rats with Vascular Dementia via p-CaMKII/ERK/CREB and ox-CaMKII-Dependent MAPK/NF-κB Pathways.
Jiang H, Ashraf GM, Liu M, Zhao K, Wang Y, Wang L, Xing J, Alghamdi BS, Li Z, Liu R
Oxidative medicine and cellular longevity 2021;2021:6673967
Oxidative medicine and cellular longevity 2021;2021:6673967
Fenofibrate Ameliorates Hepatic Ischemia/Reperfusion Injury in Mice: Involvements of Apoptosis, Autophagy, and PPAR-α Activation.
Zhang J, Cheng P, Dai W, Ji J, Wu L, Feng J, Wu J, Yu Q, Li J, Guo C
PPAR research 2021;2021:6658944
PPAR research 2021;2021:6658944
Quercetin Alleviates Intervertebral Disc Degeneration by Modulating p38 MAPK-Mediated Autophagy.
Zhang S, Liang W, Abulizi Y, Xu T, Cao R, Xun C, Zhang J, Sheng W
BioMed research international 2021;2021:6631562
BioMed research international 2021;2021:6631562
Combined Treatment of Cinobufotalin and Gefitinib Exhibits Potent Efficacy against Lung Cancer.
Han Y, Ma R, Cao G, Liu H, He L, Tang L, Li H, Luo Q
Evidence-based complementary and alternative medicine : eCAM 2021;2021:6612365
Evidence-based complementary and alternative medicine : eCAM 2021;2021:6612365
Imbalance of Autophagy and Apoptosis Induced by Oxidative Stress May Be Involved in Thyroid Damage Caused by Sleep Deprivation in Rats.
Li Y, Zhang W, Liu M, Zhang Q, Lin Z, Jia M, Liu D, Lin L
Oxidative medicine and cellular longevity 2021;2021:5645090
Oxidative medicine and cellular longevity 2021;2021:5645090
Babao Dan Reverses Multiple-Drug Resistance in Gastric Cancer Cells via Triggering Apoptosis and Autophagy and Inhibiting PI3K/AKT/mTOR Signaling.
Zhao J, Lan W, Peng J, Guan B, Liu J, Zhang M, Zhan Z, Lin J
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5631942
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5631942
Programmed NP Cell Death Induced by Mitochondrial ROS in a One-Strike Loading Disc Degeneration Organ Culture Model.
Li BL, Liu X, Gao M, Zhang F, Chen X, He Z, Wang J, Tian W, Chen D, Zhou Z, Liu S
Oxidative medicine and cellular longevity 2021;2021:5608133
Oxidative medicine and cellular longevity 2021;2021:5608133
Tubeimoside I Ameliorates Myocardial Ischemia-Reperfusion Injury through SIRT3-Dependent Regulation of Oxidative Stress and Apoptosis.
Lv D, Luo M, Cheng Z, Wang R, Yang X, Guo Y, Huang L, Li X, Huang B, Shen J, Luo S, Yan J
Oxidative medicine and cellular longevity 2021;2021:5577019
Oxidative medicine and cellular longevity 2021;2021:5577019
Study on the Antitumor Effect and Glycolysis of Andrographolide in Anaplastic Thyroid Carcinoma.
Yang K, Wu K, Feng J, Yutian L, Zhu X, Xu D
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5526581
Evidence-based complementary and alternative medicine : eCAM 2021;2021:5526581
The Role of Exercise in Reducing Hyperlipidemia-Induced Neuronal Damage in Apolipoprotein E-Deficient Mice.
Bai Y, Feng Y, Jiang B, Yang Y, Pei Z, Yang Q, Cui Y
BioMed research international 2021;2021:5512518
BioMed research international 2021;2021:5512518
Exploration of the Danggui Buxue Decoction Mechanism Regulating the Balance of ESR and AR in the TP53-AKT Signaling Pathway in the Prevention and Treatment of POF.
Liu H, Yang H, Qin Z, Chen Y, Yu H, Li W, Zhu X, Cai J, Chen J, Zhang M
Evidence-based complementary and alternative medicine : eCAM 2021;2021:4862164
Evidence-based complementary and alternative medicine : eCAM 2021;2021:4862164
The Dietary Supplement γ-Oryzanol Attenuates Hepatic Ischemia Reperfusion Injury via Inhibiting Endoplasmic Reticulum Stress and HMGB1/NLRP3 Inflammasome.
Du Y, Zhong F, Cheng H, Li T, Chen Y, Tan P, Huang M, Liang T, Liu Y, Xia X, Fu W
Oxidative medicine and cellular longevity 2021;2021:4628050
Oxidative medicine and cellular longevity 2021;2021:4628050
Effects of MicroRNA-195-5p on Biological Behaviors and Radiosensitivity of Lung Adenocarcinoma Cells via Targeting HOXA10.
Yuan C, Bai R, Gao Y, Jiang X, Li S, Sun W, Li Y, Huang Z, Gong Y, Xie C
Oxidative medicine and cellular longevity 2021;2021:4522210
Oxidative medicine and cellular longevity 2021;2021:4522210
Recombinant Human Growth Hormone Inhibits Lipotoxicity, Oxidative Stress, and Apoptosis in a Mouse Model of Diabetic Cardiomyopathy.
Pei Z, Wang X, Yang C, Dong M, Wang F
Oxidative medicine and cellular longevity 2021;2021:3899356
Oxidative medicine and cellular longevity 2021;2021:3899356
TSH Combined with TSHR Aggravates Diabetic Peripheral Neuropathy by Promoting Oxidative Stress and Apoptosis in Schwann Cells.
Fan J, Pan Q, Gao Q, Li W, Xiao F, Guo L
Oxidative medicine and cellular longevity 2021;2021:2482453
Oxidative medicine and cellular longevity 2021;2021:2482453
Trefoil Factor 3 Inhibits Thyroid Cancer Cell Progression Related to IL-6/JAK/STAT3 Signaling Pathway.
Xin Y, Shang X, Sun X, Liu Y, Xu G, Xue G
Evidence-based complementary and alternative medicine : eCAM 2021;2021:2130229
Evidence-based complementary and alternative medicine : eCAM 2021;2021:2130229
PKM2 Is a Potential Diagnostic and Therapeutic Target for Retinitis Pigmentosa.
Zhu P, Yang Q, Li G, Chang Q
Disease markers 2021;2021:1602797
Disease markers 2021;2021:1602797
miR-149 Suppresses the Proliferation and Metastasis of Human Gastric Cancer Cells by Targeting FOXC1.
Li D, Zhang Y, Li Y, Wang X, Wang F, Du J, Zhang H, Shi H, Wang Y, Gao Y, Feng Y, Yan J, Xue Y, Yang Y, Zhang J
BioMed research international 2021;2021:1503403
BioMed research international 2021;2021:1503403
USP37 downregulation elevates the Chemical Sensitivity of Human Breast Cancer Cells to Adriamycin.
Qin T, Cui XY, Xiu H, Huang C, Sun ZN, Xu XM, Li LH, Yue L
International journal of medical sciences 2021;18(2):325-334
International journal of medical sciences 2021;18(2):325-334
Cyclovirobuxine inhibits the progression of clear cell renal cell carcinoma by suppressing the IGFBP3-AKT/STAT3/MAPK-Snail signalling pathway.
Liu Y, Lv H, Li X, Liu J, Chen S, Chen Y, Jin Y, An R, Yu S, Wang Z
International journal of biological sciences 2021;17(13):3522-3537
International journal of biological sciences 2021;17(13):3522-3537
Discovery of a novel HDACi structure that inhibits the proliferation of ovarian cancer cells in vivo and in vitro.
Bai M, Cui M, Li M, Yao X, Wu Y, Zheng L, Sun L, Song Q, Wang S, Liu L, Yu C, Huang Y
International journal of biological sciences 2021;17(13):3493-3507
International journal of biological sciences 2021;17(13):3493-3507
CD44 modulates metabolic pathways and altered ROS-mediated Akt signal promoting cholangiocarcinoma progression.
Thanee M, Dokduang H, Kittirat Y, Phetcharaburanin J, Klanrit P, Titapun A, Namwat N, Khuntikeo N, Wangwiwatsin A, Saya H, Loilome W
PloS one 2021;16(3):e0245871
PloS one 2021;16(3):e0245871
Glucocorticoids protect HEI-OC1 cells from tunicamycin-induced cell damage via inhibiting endoplasmic reticulum stress.
Liu Z, Fei B, Xie L, Liu J, Chen X, Zhu W, Lv L, Ma W, Gao Z, Hou J, She W
Open life sciences 2021;16(1):695-702
Open life sciences 2021;16(1):695-702
Delivery of Rapamycin by Liposomes Synergistically Enhances the Chemotherapy Effect of 5-Fluorouracil on Colorectal Cancer.
Chen YQ, Zhu WT, Lin CY, Yuan ZW, Li ZH, Yan PK
International journal of nanomedicine 2021;16:269-281
International journal of nanomedicine 2021;16:269-281
Total Flavonoids of Chuju Decrease Oxidative Stress and Cell Apoptosis in Ischemic Stroke Rats: Network and Experimental Analyses.
Wang C, Chen H, Jiang HH, Mao BB, Yu H
Frontiers in neuroscience 2021;15:772401
Frontiers in neuroscience 2021;15:772401
Baicalin Alleviates Oxidative Stress and Inflammation in Diabetic Nephropathy via Nrf2 and MAPK Signaling Pathway.
Ma L, Wu F, Shao Q, Chen G, Xu L, Lu F
Drug design, development and therapy 2021;15:3207-3221
Drug design, development and therapy 2021;15:3207-3221
Gypenosides Inhibit Inflammatory Response and Apoptosis of Endothelial and Epithelial Cells in LPS-Induced ALI: A Study Based on Bioinformatic Analysis and in vivo/vitro Experiments.
Tu Q, Zhu Y, Yuan Y, Guo L, Liu L, Yao L, Zou Y, Li J, Chen F
Drug design, development and therapy 2021;15:289-303
Drug design, development and therapy 2021;15:289-303
Effect of luteolin on apoptosis and vascular endothelial growth factor in human choroidal melanoma cells.
Shi ML, Chen YF, Liao HF
International journal of ophthalmology 2021;14(2):186-193
International journal of ophthalmology 2021;14(2):186-193
Engeletin Protects Against TNF-α-Induced Apoptosis and Reactive Oxygen Species Generation in Chondrocytes and Alleviates Osteoarthritis in vivo.
Wang H, Jiang Z, Pang Z, Qi G, Hua B, Yan Z, Yuan H
Journal of inflammation research 2021;14:745-760
Journal of inflammation research 2021;14:745-760
Hydrogen (H(2)) Alleviates Osteoarthritis by Inhibiting Apoptosis and Inflammation via the JNK Signaling Pathway.
Lu H, Wang W, Kang X, Lin Z, Pan J, Cheng S, Zhang J
Journal of inflammation research 2021;14:1387-1402
Journal of inflammation research 2021;14:1387-1402
lncRNA AC007207.2 Promotes Malignant Properties of Osteosarcoma via the miR-1306-5p/SIRT7 Axis.
Dang Y, Zhou Y, Ou X, Wang Q, Wei D, Xie F
Cancer management and research 2021;13:7277-7288
Cancer management and research 2021;13:7277-7288
MALAT-1 is Associated with the Doxorubicin Resistance in U-2OS Osteosarcoma Cells.
Liu C, Han X, Li B, Huang S, Zhou Z, Wang Z, Wang W
Cancer management and research 2021;13:6879-6889
Cancer management and research 2021;13:6879-6889
Analysis of m6A-Related lncRNAs for Prognosis Value and Response to Immune Checkpoint Inhibitors Therapy in Hepatocellular Carcinoma.
Wang Y, Li N, Tian D, Zhou CW, Wang YH, Yang C, Zeng MS
Cancer management and research 2021;13:6451-6471
Cancer management and research 2021;13:6451-6471
High-Fat Diet-Induced Mitochondrial Dysfunction Promotes Genioglossus Injury - A Potential Mechanism for Obstructive Sleep Apnea with Obesity.
Chen Q, Han X, Chen M, Zhao B, Sun B, Sun L, Zhang W, Yu L, Liu Y
Nature and science of sleep 2021;13:2203-2219
Nature and science of sleep 2021;13:2203-2219
SAA1 knockdown promotes the apoptosis of glioblastoma cells via downregulation of AKT signaling.
Zhang H, Xu Y, Deng G, Yuan F, Tan Y, Gao L, Sun Q, Qi Y, Yang K, Geng R, Jiang H, Liu B, Chen Q
Journal of Cancer 2021;12(9):2756-2767
Journal of Cancer 2021;12(9):2756-2767
ARRB1 Drives Gallbladder Cancer Progression by Facilitating TAK1/MAPK Signaling Activation.
Zhang X, Kong Z, Xu X, Yun X, Chao J, Ding D, Li T, Gao Y, Guan N, Zhu C, Qin X
Journal of Cancer 2021;12(7):1926-1935
Journal of Cancer 2021;12(7):1926-1935
Keratin 80 regulated by miR-206/ETS1 promotes tumor progression via the MEK/ERK pathway in ovarian cancer.
Liu O, Wang C, Wang S, Hu Y, Gou R, Dong H, Li S, Li X, Lin B
Journal of Cancer 2021;12(22):6835-6850
Journal of Cancer 2021;12(22):6835-6850
Demethylzelasteral inhibits proliferation and EMT via repressing Wnt/β-catenin signaling in esophageal squamous cell carcinoma.
Yu J, Wang W, Liu B, Gu J, Chen S, Cui Y, Sun G
Journal of Cancer 2021;12(13):3967-3975
Journal of Cancer 2021;12(13):3967-3975
Myricanol Inhibits Platelet Derived Growth Factor-BB-Induced Vascular Smooth Muscle Cells Proliferation and Migration in vitro and Intimal Hyperplasia in vivo by Targeting the Platelet-Derived Growth Factor Receptor-β and NF-κB Signaling.
Fan S, Wang C, Huang K, Liang M
Frontiers in physiology 2021;12:790345
Frontiers in physiology 2021;12:790345
Baicalein Alleviates Osteoarthritis Progression in Mice by Protecting Subchondral Bone and Suppressing Chondrocyte Apoptosis Based on Network Pharmacology.
Yi N, Mi Y, Xu X, Li N, Zeng F, Yan K, Tan K, Kuang G, Lu M
Frontiers in pharmacology 2021;12:788392
Frontiers in pharmacology 2021;12:788392
An Endogenous Retroviral LTR-Derived Long Noncoding RNA lnc-LTR5B Interacts With BiP to Modulate ALV-J Replication in Chicken Cells.
Chen S, Zhao R, Wu T, Wang D, Wang B, Pan S, Hu X, Pan Z, Cui H
Frontiers in microbiology 2021;12:788317
Frontiers in microbiology 2021;12:788317
Exercise Capacity Is Improved by Levosimendan in Heart Failure and Sarcopenia via Alleviation of Apoptosis of Skeletal Muscle.
Wang D, Song M, Shen LF, Han L, Zhu P, Jia X, Shang GK, Cao Y, Zhang W, Zhong M, Wang ZH
Frontiers in physiology 2021;12:786895
Frontiers in physiology 2021;12:786895
Qingda Granule Attenuates Angiotensin II-Induced Renal Apoptosis and Activation of the p53 Pathway.
Long L, Zhang X, Wen Y, Li J, Wei L, Cheng Y, Liu H, Chu J, Fang Y, Xie Q, Shen A, Peng J
Frontiers in pharmacology 2021;12:770863
Frontiers in pharmacology 2021;12:770863
Sempervirine Mediates Autophagy and Apoptosis via the Akt/mTOR Signaling Pathways in Glioma Cells.
Li G, Zhong Y, Wang W, Jia X, Zhu H, Jiang W, Song Y, Xu W, Wu S
Frontiers in pharmacology 2021;12:770667
Frontiers in pharmacology 2021;12:770667
Salmonella Infantis Delays the Death of Infected Epithelial Cells to Aggravate Bacterial Load by Intermittent Phosphorylation of Akt With SopB.
Chu BX, Li YN, Liu N, Yuan LX, Chen SY, Zhu YH, Wang JF
Frontiers in immunology 2021;12:757909
Frontiers in immunology 2021;12:757909
Transcriptomic Profiling Reveals the Antiapoptosis and Antioxidant Stress Effects of Fos in Ischemic Stroke.
Mu Q, Zhang Y, Gu L, Gerner ST, Qiu X, Tao Q, Pang J, Dipritu G, Zhang L, Yin S, Jiang Y, Peng J
Frontiers in neurology 2021;12:728984
Frontiers in neurology 2021;12:728984
The Abscopal Effects of Cranial Irradiation Induce Testicular Damage in Mice.
Guo L, Qin TZ, Liu LY, Lai PP, Xue YZ, Jing YT, Zhang W, Li W, Li J, Ding GR
Frontiers in physiology 2021;12:717571
Frontiers in physiology 2021;12:717571
Ivermectin has New Application in Inhibiting Colorectal Cancer Cell Growth.
Zhou S, Wu H, Ning W, Wu X, Xu X, Ma Y, Li X, Hu J, Wang C, Wang J
Frontiers in pharmacology 2021;12:717529
Frontiers in pharmacology 2021;12:717529
Lactobacillus rhamnosus GR-1 Prevents Escherichia coli-Induced Apoptosis Through PINK1/Parkin-Mediated Mitophagy in Bovine Mastitis.
Li Y, Zhu Y, Chu B, Liu N, Chen S, Wang J
Frontiers in immunology 2021;12:715098
Frontiers in immunology 2021;12:715098
Myricetin Induces Autophagy and Cell Cycle Arrest of HCC by Inhibiting MARCH1-Regulated Stat3 and p38 MAPK Signaling Pathways.
Yang W, Su J, Li M, Li T, Wang X, Zhao M, Hu X
Frontiers in pharmacology 2021;12:709526
Frontiers in pharmacology 2021;12:709526
PBK/TOPK Inhibitor Suppresses the Progression of Prolactinomas.
Zhu K, Cheng X, Wang S, Zhang H, Zhang Y, Wang X, Chen Y, Wu J
Frontiers in endocrinology 2021;12:706909
Frontiers in endocrinology 2021;12:706909
miR-344-5p Modulates Cholesterol-Induced β-Cell Apoptosis and Dysfunction Through Regulating Caveolin-1 Expression.
Sun X, Ji G, Li P, Li W, Li J, Zhu L
Frontiers in endocrinology 2021;12:695164
Frontiers in endocrinology 2021;12:695164
Autophagy is Involved in Neuroprotective Effect of Alpha7 Nicotinic Acetylcholine Receptor on Ischemic Stroke.
Xu ZQ, Zhang JJ, Kong N, Zhang GY, Ke P, Han T, Su DF, Liu C
Frontiers in pharmacology 2021;12:676589
Frontiers in pharmacology 2021;12:676589
Targeting Glycogen Synthase Kinase 3 Beta Regulates CD47 Expression After Myocardial Infarction in Rats via the NF-κB Signaling Pathway.
Xu LN, Wang SH, Su XL, Komal S, Fan HK, Xia L, Zhang LR, Han SN
Frontiers in pharmacology 2021;12:662726
Frontiers in pharmacology 2021;12:662726
The New PI3K/mTOR Inhibitor GNE-477 Inhibits the Malignant Behavior of Human Glioblastoma Cells.
Wang Y, Shen H, Sun Q, Zhao L, Liu H, Ye L, Xu Y, Cai J, Li Y, Gao L, Tan Y, Liu B, Chen Q
Frontiers in pharmacology 2021;12:659511
Frontiers in pharmacology 2021;12:659511
Aldehyde Dehydrogenase 2 Protects Against Lipopolysaccharide-Induced Myocardial Injury by Suppressing Mitophagy.
Ji W, Wan T, Zhang F, Zhu X, Guo S, Mei X
Frontiers in pharmacology 2021;12:641058
Frontiers in pharmacology 2021;12:641058
Oxytocin Attenuates Methamphetamine-Induced Apoptosis via Oxytocin Receptor in Rat Hippocampal Neurons.
Li C, Wang H, Wang M, Chen C, Bai F, Ban M, Wu C
Frontiers in pharmacology 2021;12:639571
Frontiers in pharmacology 2021;12:639571
Inhibition of BAG3 enhances the anticancer effect of shikonin in hepatocellular carcinoma.
Lu J, Liu SY, Zhang J, Yang GM, Gao GB, Yu NN, Li YP, Li YX, Ma ZQ, Wang Y, Lu CH
American journal of cancer research 2021;11(7):3575-3593
American journal of cancer research 2021;11(7):3575-3593
The 14-3-3σ protein promotes HCC anoikis resistance by inhibiting EGFR degradation and thereby activating the EGFR-dependent ERK1/2 signaling pathway.
Song J, Liu Y, Liu F, Zhang L, Li G, Yuan C, Yu C, Lu X, Liu Q, Chen X, Liang H, Ding Z, Zhang B
Theranostics 2021;11(3):996-1015
Theranostics 2021;11(3):996-1015
Relieving lipid accumulation through UCP1 suppresses the progression of acute kidney injury by promoting the AMPK/ULK1/autophagy pathway.
Xiong W, Xiong Z, Song A, Lei C, Ye C, Zhang C
Theranostics 2021;11(10):4637-4654
Theranostics 2021;11(10):4637-4654
Hedgehog-Gli2 Signaling Promotes Chemoresistance in Ovarian Cancer Cells by Regulating MDR1.
Wang Q, Wei X, Hu L, Zhuang L, Zhang H, Chen Q
Frontiers in oncology 2021;11:794959
Frontiers in oncology 2021;11:794959
Deferoxamine Counteracts Cisplatin Resistance in A549 Lung Adenocarcinoma Cells by Increasing Vulnerability to Glutamine Deprivation-Induced Cell Death.
Liu WJ, Pan PY, Sun Y, Wang JB, Zhou H, Xie X, Duan ZY, Dong HY, Chen WN, Zhang LD, Wang C
Frontiers in oncology 2021;11:794735
Frontiers in oncology 2021;11:794735
Identification of CDCA2 as a Diagnostic and Prognostic Marker for Hepatocellular Carcinoma.
Yu Z, Zhang Y, Shao S, Liu Q, Li Y, Du X, Zhang K, Zhang M, Yuan H, Yuan Q, Liu T, Gao Y, Wang Y, Hong W, Han T
Frontiers in oncology 2021;11:755814
Frontiers in oncology 2021;11:755814
Periplocymarin Induced Colorectal Cancer Cells Apoptosis Via Impairing PI3K/AKT Pathway.
Cheng Y, Wang G, Zhao L, Dai S, Han J, Hu X, Zhou C, Wang F, Ma H, Li B, Meng Z
Frontiers in oncology 2021;11:753598
Frontiers in oncology 2021;11:753598
Ursolic Acid Inhibits Breast Cancer Metastasis by Suppressing Glycolytic Metabolism via Activating SP1/Caveolin-1 Signaling.
Wang S, Chang X, Zhang J, Li J, Wang N, Yang B, Pan B, Zheng Y, Wang X, Ou H, Wang Z
Frontiers in oncology 2021;11:745584
Frontiers in oncology 2021;11:745584
Targeting NUFIP1 Suppresses Growth and Induces Senescence of Colorectal Cancer Cells.
Shen A, Wu M, Liu L, Chen Y, Chen X, Zhuang M, Xie Q, Cheng Y, Li J, Shen Z, Wei L, Chu J, Sferra TJ, Zhang X, Xu N, Li L, Peng J, Chen F
Frontiers in oncology 2021;11:681425
Frontiers in oncology 2021;11:681425
NUDT21 Promotes Tumor Growth and Metastasis Through Modulating SGPP2 in Human Gastric Cancer.
Zhu Y, Zhang R, Zhang Y, Cheng X, Li L, Wu Z, Ding K
Frontiers in oncology 2021;11:670353
Frontiers in oncology 2021;11:670353
Pinocembrin Inhibits the Proliferation and Metastasis of Breast Cancer via Suppression of the PI3K/AKT Signaling Pathway.
Zhu X, Li R, Wang C, Zhou S, Fan Y, Ma S, Gao D, Gai N, Yang J
Frontiers in oncology 2021;11:661184
Frontiers in oncology 2021;11:661184
The lncRNA ADAMTS9-AS2 Regulates RPL22 to Modulate TNBC Progression via Controlling the TGF-β Signaling Pathway.
Ni K, Huang Z, Zhu Y, Xue D, Jin Q, Zhang C, Gu C
Frontiers in oncology 2021;11:654472
Frontiers in oncology 2021;11:654472
N6-Methyladenosine Modification of LncRNA DUXAP9 Promotes Renal Cancer Cells Proliferation and Motility by Activating the PI3K/AKT Signaling Pathway.
Tan L, Tang Y, Li H, Li P, Ye Y, Cen J, Gui C, Luo J, Cao J, Wei J
Frontiers in oncology 2021;11:641833
Frontiers in oncology 2021;11:641833
MiR-454-3p Promotes Oxaliplatin Resistance by Targeting PTEN in Colorectal Cancer.
Qian XL, Zhou F, Xu S, Jiang J, Chen ZP, Wang SK, Zuo Y, Ni C
Frontiers in oncology 2021;11:638537
Frontiers in oncology 2021;11:638537
Epigallocatechin-3-gallate inhibits proliferation and triggers apoptosis in colon cancer via the hedgehog/phosphoinositide 3-kinase pathways.
Ding F, Yang S
Canadian journal of physiology and pharmacology 2021 Sep;99(9):910-920
Canadian journal of physiology and pharmacology 2021 Sep;99(9):910-920
TLR2 inhibition ameliorates the amplification effect of LPS on lipid accumulation and lipotoxicity in hepatic cells.
Zhang L, Xie Z, Yu H, Du H, Wang X, Cai J, Qiu Y, Chen R, Jiang X, Liu Z, Li Y, Chen T
Annals of translational medicine 2021 Sep;9(18):1429
Annals of translational medicine 2021 Sep;9(18):1429
Homoharringtonine inhibits the progression of hepatocellular carcinoma by suppressing the PI3K/AKT/GSK3β/Slug signaling pathway.
Liu HY, Dong TX, Li ZZ, Li TT, Jiang J, Zhu MW, An TT, Chen YD, Yang XH
Neoplasma 2021 Sep;68(5):924-937
Neoplasma 2021 Sep;68(5):924-937
Environmental Microcystin exposure in underlying NAFLD-induced exacerbation of neuroinflammation, blood-brain barrier dysfunction, and neurodegeneration are NLRP3 and S100B dependent.
Mondal A, Saha P, Bose D, Chatterjee S, Seth RK, Xiao S, Porter DE, Brooks BW, Scott GI, Nagarkatti M, Nagarkatti P, Chatterjee S
Toxicology 2021 Sep;461:152901
Toxicology 2021 Sep;461:152901
Triclosan regulates the Nrf2/HO-1 pathway through the PI3K/Akt/JNK signaling cascade to induce oxidative damage in neurons.
Wang D, Liu J, Jiang H
Environmental toxicology 2021 Sep;36(9):1953-1964
Environmental toxicology 2021 Sep;36(9):1953-1964
Role of Notch pathway in effect of mono-2-ethylhexyl phthalate on the proliferation and cell cycle of SH-SY5Y cell.
Zhang B, Li X, Zhang X, Ye J, Zhao W, Zhang M, Xing J, Qi W, Ye L
Environmental toxicology 2021 Sep;36(9):1944-1952
Environmental toxicology 2021 Sep;36(9):1944-1952
Docosahexaenoic acid activates the Nrf2 signaling pathway to alleviate impairment of spleen cellular immunity in intrauterine growth restricted rat pups.
Jiang W, Wan L, Chen P, Lu W
Saudi journal of biological sciences 2021 Sep;28(9):4987-4993
Saudi journal of biological sciences 2021 Sep;28(9):4987-4993
miR‑140‑5p alleviates mouse liver ischemia/reperfusion injury by targeting CAPN1.
Yu Q, Chen S, Tang H, Yang H, Zhang J, Shi X, Li J, Guo W, Zhang S
Molecular medicine reports 2021 Sep;24(3)
Molecular medicine reports 2021 Sep;24(3)
Expression and purification of a recombinant ELRL-MAP30 with dual-targeting anti-tumor bioactivity.
Chen WW, Zhang HR, Huang ZG, Zhou ZY, Lou QW, Jiang XY, Zhu ZH
Protein expression and purification 2021 Sep;185:105893
Protein expression and purification 2021 Sep;185:105893
Scutellarin ameliorates colitis-associated colorectal cancer by suppressing Wnt/β-catenin signaling cascade.
Zeng S, Chen L, Sun Q, Zhao H, Yang H, Ren S, Liu M, Meng X, Xu H
European journal of pharmacology 2021 Sep 5;906:174253
European journal of pharmacology 2021 Sep 5;906:174253
A self-amplified nanocatalytic system for achieving "1 + 1 + 1 > 3" chemodynamic therapy on triple negative breast cancer.
Zhou L, Chen J, Sun Y, Chai K, Zhu Z, Wang C, Chen M, Han W, Hu X, Li R, Yao T, Li H, Dong C, Shi S
Journal of nanobiotechnology 2021 Sep 4;19(1):261
Journal of nanobiotechnology 2021 Sep 4;19(1):261
Fibroblast growth factor 21 (FGF21) alleviates senescence, apoptosis, and extracellular matrix degradation in osteoarthritis via the SIRT1-mTOR signaling pathway.
Lu H, Jia C, Wu D, Jin H, Lin Z, Pan J, Li X, Wang W
Cell death & disease 2021 Sep 23;12(10):865
Cell death & disease 2021 Sep 23;12(10):865
Xenon Nanobubbles for the Image-Guided Preemptive Treatment of Acute Ischemic Stroke via Neuroprotection and Microcirculatory Restoration.
Jin J, Li M, Li J, Li B, Duan L, Yang F, Gu N
ACS applied materials & interfaces 2021 Sep 22;13(37):43880-43891
ACS applied materials & interfaces 2021 Sep 22;13(37):43880-43891
Orexin-A Regulates Follicular Growth, Proliferation, Cell Cycle and Apoptosis in Mouse Primary Granulosa Cells via the AKT/ERK Signaling Pathway.
Safdar M, Liang A, Rajput SA, Abbas N, Zubair M, Shaukat A, Rehman AU, Jamil H, Guo Y, Ullah F, Yang L
Molecules (Basel, Switzerland) 2021 Sep 16;26(18)
Molecules (Basel, Switzerland) 2021 Sep 16;26(18)
Chitosan-based nanoparticle co-delivery of docetaxel and curcumin ameliorates anti-tumor chemoimmunotherapy in lung cancer.
Zhu X, Yu Z, Feng L, Deng L, Fang Z, Liu Z, Li Y, Wu X, Qin L, Guo R, Zheng Y
Carbohydrate polymers 2021 Sep 15;268:118237
Carbohydrate polymers 2021 Sep 15;268:118237
Scoparone inhibits pancreatic cancer through PI3K/Akt signaling pathway.
Li N, Yang F, Liu DY, Guo JT, Ge N, Sun SY
World journal of gastrointestinal oncology 2021 Sep 15;13(9):1164-1183
World journal of gastrointestinal oncology 2021 Sep 15;13(9):1164-1183
Tetrahydropalmatine Regulates BDNF through TrkB/CAM Interaction to Alleviate the Neurotoxicity Induced by Methamphetamine.
Liu L, Liu M, Zhao W, Zhao YL, Wang Y
ACS chemical neuroscience 2021 Sep 15;12(18):3373-3386
ACS chemical neuroscience 2021 Sep 15;12(18):3373-3386
Effect of different exercise training intensities on age-related cardiac damage in male mice.
Pei Z, Yang C, Guo Y, Dong M, Wang F
Aging 2021 Sep 14;13(17):21700-21711
Aging 2021 Sep 14;13(17):21700-21711
Bortezomib enhances the anti-cancer effect of the novel Bruton's tyrosine kinase inhibitor (BGB-3111) in mantle cell lymphoma expressing BTK.
Wang X, Fei Y, Liu X, Zhang T, Li W, Jia X, Liu X, Qiu L, Qian Z, Zhou S, Ren X, Zhai Q, Meng B, Li L, Zhang H
Aging 2021 Sep 10;13(17):21102-21121
Aging 2021 Sep 10;13(17):21102-21121
IL-22 ameliorated cardiomyocyte apoptosis in cardiac ischemia/reperfusion injury by blocking mitochondrial membrane potential decrease, inhibiting ROS and cytochrome C.
Che Y, Tian Y, Chen R, Xia L, Liu F, Su Z
Biochimica et biophysica acta. Molecular basis of disease 2021 Sep 1;1867(9):166171
Biochimica et biophysica acta. Molecular basis of disease 2021 Sep 1;1867(9):166171
miR-132-3p promotes the cisplatin-induced apoptosis and inflammatory response of renal tubular epithelial cells by targeting SIRT1 via the NF-κB pathway.
Han S, Lin F, Ruan Y, Zhao S, Yuan R, Ning J, Jiang K, Xie J, Li H, Li C, Rao T, Yu W, Xia Y, Zhou X, Cheng F
International immunopharmacology 2021 Oct;99:108022
International immunopharmacology 2021 Oct;99:108022
Enhancement of gemcitabine efficacy by K73-03 via epigenetically regulation of miR-421/SPINK1 in gemcitabine resistant pancreatic cancer cells.
Shopit A, Li X, Wang S, Awsh M, Safi M, Chu P, Jia J, Al-Radhi M, Baldi S, Wang F, Fang J, Peng J, Ma X, Tang Z, Shu X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Oct;91:153711
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Oct;91:153711
Metformin alleviates bevacizumab-induced vascular endothelial injury by up-regulating GDF15 and activating the PI3K/AKT/FOXO/PPARγ signaling pathway.
Chen L, Yin Y, Liu G
Annals of translational medicine 2021 Oct;9(20):1547
Annals of translational medicine 2021 Oct;9(20):1547
Alpha-ketoglutarate ameliorates pressure overload-induced chronic cardiac dysfunction in mice.
An D, Zeng Q, Zhang P, Ma Z, Zhang H, Liu Z, Li J, Ren H, Xu D
Redox biology 2021 Oct;46:102088
Redox biology 2021 Oct;46:102088
Arctigenin inhibits cholangiocarcinoma progression by regulating cell migration and cell viability via the N-cadherin and apoptosis pathway.
Janthamala S, Jusakul A, Kongpetch S, Kimawaha P, Klanrit P, Loilome W, Namwat N, Techasen A
Naunyn-Schmiedeberg's archives of pharmacology 2021 Oct;394(10):2049-2059
Naunyn-Schmiedeberg's archives of pharmacology 2021 Oct;394(10):2049-2059
Inhibition of ER stress attenuates kidney injury and apoptosis induced by 3-MCPD via regulating mitochondrial fission/fusion and Ca(2+) homeostasis.
Zhong Y, Jin C, Han J, Zhu J, Liu Q, Sun D, Xia X, Peng X
Cell biology and toxicology 2021 Oct;37(5):795-809
Cell biology and toxicology 2021 Oct;37(5):795-809
Exosomes derived from idiopathic gingival fibroma fibroblasts regulate gingival fibroblast proliferation and apoptosis.
Yin S, Jia F, Ran L, Xie L, Wu Z, Zhan Y, Zhang Y, Zhang M
Oral diseases 2021 Oct;27(7):1789-1795
Oral diseases 2021 Oct;27(7):1789-1795
Adiponectin regulates osteocytic MLO-Y4 cell apoptosis in a high-glucose environment through the AMPK/FoxO3a signaling pathway.
Zeng Y, Liang H, Guo Y, Feng Y, Yao Q
Journal of cellular physiology 2021 Oct;236(10):7088-7096
Journal of cellular physiology 2021 Oct;236(10):7088-7096
ST8SIA1 inhibits the proliferation, migration and invasion of bladder cancer cells by blocking the JAK/STAT signaling pathway.
Yu S, Wang S, Sun X, Wu Y, Zhao J, Liu J, Yang D, Jiang Y
Oncology letters 2021 Oct;22(4):736
Oncology letters 2021 Oct;22(4):736
Overexpression of E74-like transformation-specific transcription factor 3 promotes cellular proliferation and predicts poor prognosis in ovarian cancer.
Liu Y, Wang S, Zhou R, Li W, Zhang G
Oncology letters 2021 Oct;22(4):710
Oncology letters 2021 Oct;22(4):710
Hsa_circ_0004058 inhibits apoptosis of SRA01/04 cells by promoting autophagy via miR-186/ATG7 axis.
Wang Y, Wu Z, Huang Y, Zhang Y
Experimental eye research 2021 Oct;211:108721
Experimental eye research 2021 Oct;211:108721
RSL3 enhances the antitumor effect of cisplatin on prostate cancer cells via causing glycolysis dysfunction.
Li M, Chen X, Wang X, Wei X, Wang D, Liu X, Xu L, Batu W, Li Y, Guo B, Zhang L
Biochemical pharmacology 2021 Oct;192:114741
Biochemical pharmacology 2021 Oct;192:114741
LncRNA-Malat1 down-regulates miR-211-5p expression to promote neuronal damage from cerebral ischemia reperfusion injury.
Tan X, Guo W, Peng Z, Gu C, Xiang P, Tu Y, Fei H, Liu X, Lu Y, Li M, Wang H, Luo Y, Yang J
Biochemical pharmacology 2021 Oct;192:114694
Biochemical pharmacology 2021 Oct;192:114694
Panax notoginseng saponins reduces the cisplatin-induced acute renal injury by increasing HIF-1α/BNIP3 to inhibit mitochondrial apoptosis pathway.
Li Q, Zhang Y, Yang Y, Huang S, Zou X, Wei C, Liang T, Zhong X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Oct;142:111965
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Oct;142:111965
Silent information regulator 2 promotes clear cell renal cell carcinoma progression through deacetylation and small ubiquitin-related modifier 1 modification of glucose 6-phosphate dehydrogenase.
Ni Y, Yang Z, Agbana YL, Bai H, Wang L, Yang L, Yi Z, Cheng J, Zhang Q, Kuang Y, Zhu Y
Cancer science 2021 Oct;112(10):4075-4086
Cancer science 2021 Oct;112(10):4075-4086
Long-term repetitive exposure to excess iodine induces mitochondrial apoptosis, and alters monoamine neurotransmitters in hippocampus of rats of different genders.
Cui Y, Zhang B, Zhang Z, Nie J, Liu H
Toxicology research 2021 Oct;10(5):975-982
Toxicology research 2021 Oct;10(5):975-982
sTNFRII-Fc modification protects human UC-MSCs against apoptosis/autophagy induced by TNF-α and enhances their efficacy in alleviating inflammatory arthritis.
Zhao Y, Yang X, Li S, Zhang B, Li S, Wang X, Wang Y, Jia C, Chang Y, Wei W
Stem cell research & therapy 2021 Oct 9;12(1):535
Stem cell research & therapy 2021 Oct 9;12(1):535
ECHS1, an interacting protein of LASP1, induces sphingolipid-metabolism imbalance to promote colorectal cancer progression by regulating ceramide glycosylation.
Li R, Hao Y, Wang Q, Meng Y, Wu K, Liu C, Xu L, Liu Z, Zhao L
Cell death & disease 2021 Oct 6;12(10):911
Cell death & disease 2021 Oct 6;12(10):911
Diosgenin exerts anti-tumor effects through inactivation of cAMP/PKA/CREB signaling pathway in colorectal cancer.
Li SY, Shang J, Mao XM, Fan R, Li HQ, Li RH, Shen DY
European journal of pharmacology 2021 Oct 5;908:174370
European journal of pharmacology 2021 Oct 5;908:174370
Anti-Cancer Properties of Ginkgolic Acids in Human Nasopharyngeal Carcinoma CNE-2Z Cells via Inhibition of Heat Shock Protein 90.
Li HM, Ma H, Sun X, Li B, Cao C, Dai Y, Zhu M, Wu CZ
Molecules (Basel, Switzerland) 2021 Oct 30;26(21)
Molecules (Basel, Switzerland) 2021 Oct 30;26(21)
The biological effect of cobalt chloride mimetic-hypoxia on nucleus pulposus cells and the comparability with physical hypoxia in vitro.
Gao XX, Liu CH, Hu ZL, Li HY, Chang X, Li YY, Zhang YY, Zhai Y, Li CQ
Frontiers in bioscience (Landmark edition) 2021 Oct 30;26(10):799-812
Frontiers in bioscience (Landmark edition) 2021 Oct 30;26(10):799-812
Activation of G protein coupled estrogen receptor prevents chemotherapy-induced intestinal mucositis by inhibiting the DNA damage in crypt cell in an extracellular signal-regulated kinase 1- and 2- dependent manner.
Chen G, Zeng H, Li X, Liu J, Li Z, Xu R, Ma Y, Liu C, Xue B
Cell death & disease 2021 Oct 30;12(11):1034
Cell death & disease 2021 Oct 30;12(11):1034
Disruption of Gprasp2 down-regulates Hedgehog signaling and leads to apoptosis in auditory cells.
Lu Y, Zhang M, Wei Q, Chen Z, Xing G, Yao J, Cao X
Biochemical and biophysical research communications 2021 Oct 15;574:1-7
Biochemical and biophysical research communications 2021 Oct 15;574:1-7
MiR-10b-5p inhibits tumorigenesis in gastric cancer xenograft mice model through down-regulating Tiam1.
Liu F, An X, Zhao X, Zhang N, Chen B, Li Z, Xu W
Experimental cell research 2021 Oct 15;407(2):112810
Experimental cell research 2021 Oct 15;407(2):112810
Co-modification with MSC membrane and PDA prevents Fe(3)O(4)-induced pulmonary toxicity in mice via AMPK-ULK1 axis.
Yao H, Yan J, Shao P, Wang Y, Liu T, Jiang J, Liu T
Toxicology letters 2021 Oct 15;351:145-154
Toxicology letters 2021 Oct 15;351:145-154
Design, synthesis, and biological evaluation of 2,4-diamino pyrimidine derivatives as potent FAK inhibitors with anti-cancer and anti-angiogenesis activities.
Wang S, Zhang RH, Zhang H, Wang YC, Yang D, Zhao YL, Yan GY, Xu GB, Guan HY, Zhou YH, Cui DB, Liu T, Li YJ, Liao SG, Zhou M
European journal of medicinal chemistry 2021 Oct 15;222:113573
European journal of medicinal chemistry 2021 Oct 15;222:113573
SMAD2 regulates testicular development and testosterone synthesis in Hu sheep.
Yang H, Wan Z, Jin Y, Wang F, Zhang Y
Theriogenology 2021 Oct 15;174:139-148
Theriogenology 2021 Oct 15;174:139-148
Methamphetamine mediates apoptosis of vascular smooth muscle cells via the chop-related endoplasmic reticulum stress pathway.
Tan X, Cai D, Chen N, Du S, Qiao D, Yue X, Wang T, Li J, Xie W, Wang H
Toxicology letters 2021 Oct 10;350:98-110
Toxicology letters 2021 Oct 10;350:98-110
GRIM-19 inhibits proliferation and induces apoptosis in a p53-dependent manner in colorectal cancer cells through the SIRT7/PCAF/MDM2 axis.
Wang D, Wei X, Chen X, Wang Q, Zhang J, Kalvakolanu DV, Guo B, Zhang L
Experimental cell research 2021 Oct 1;407(1):112799
Experimental cell research 2021 Oct 1;407(1):112799
Harpagide alleviate neuronal apoptosis and blood-brain barrier leakage by inhibiting TLR4/MyD88/NF-κB signaling pathway in Angiotensin II-induced microglial activation in vitro.
Lu Y, Hao R, Hu Y, Wei Y, Xie Y, Shen Y, Rui Q, Yu G
Chemico-biological interactions 2021 Oct 1;348:109653
Chemico-biological interactions 2021 Oct 1;348:109653
A-24, a steroidal saponin from Allium chinense, induced apoptosis, autophagy and migration inhibition in p53 wild-type and p53-deficient gastric cancer cells.
Xu J, Wang Y, Wang Y, Wang Z, He X
Chemico-biological interactions 2021 Oct 1;348:109648
Chemico-biological interactions 2021 Oct 1;348:109648
MiR-223-3p targets FOXO3a to inhibit radiosensitivity in prostate cancer by activating glycolysis.
Zhou K, Wei Y, Li X, Yang X
Life sciences 2021 Oct 1;282:119798
Life sciences 2021 Oct 1;282:119798
Arsenic trioxide induces expression of BCL-2 expression via NF-κB and p38 MAPK signaling pathways in BEAS-2B cells during apoptosis.
Tang J, Yao C, Liu Y, Yuan J, Wu L, Hosoi K, Yu S, Huang C, Wei H, Chen G
Ecotoxicology and environmental safety 2021 Oct 1;222:112531
Ecotoxicology and environmental safety 2021 Oct 1;222:112531
Antagonizing effects of curcumin against mercury-induced autophagic death and trace elements disorder by regulating PI3K/AKT and Nrf2 pathway in the spleen.
Zhao G, Qi L, Wang Y, Li X, Li Q, Tang X, Wang X, Wu C
Ecotoxicology and environmental safety 2021 Oct 1;222:112529
Ecotoxicology and environmental safety 2021 Oct 1;222:112529
Comparison of biological and transcriptomic effects of conventional cigarette and electronic cigarette smoke exposure at toxicological dose in BEAS-2B cells.
Wang L, Wang Y, Chen J, Yang XM, Jiang XT, Liu P, Li M
Ecotoxicology and environmental safety 2021 Oct 1;222:112472
Ecotoxicology and environmental safety 2021 Oct 1;222:112472
Patient-Derived Organoids Can Guide Personalized-Therapies for Patients with Advanced Breast Cancer.
Chen P, Zhang X, Ding R, Yang L, Lyu X, Zeng J, Lei JH, Wang L, Bi J, Shao N, Shu D, Wu B, Wu J, Yang Z, Wang H, Wang B, Xiong K, Lu Y, Fu S, Choi TK, Lon NW, Zhang A, Tang D, Quan Y, Meng Y, Miao K, Sun H, Zhao M, Bao J, Zhang L, Xu X, Shi Y, Lin Y, Deng C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Nov;8(22):e2101176
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Nov;8(22):e2101176
Abnormally elevated ubiquilin‑1 expression in breast cancer regulates metastasis and stemness via AKT signaling.
Feng X, Cao A, Qin T, Zhang Q, Fan S, Wang B, Song B, Yu X, Li L
Oncology reports 2021 Nov;46(5)
Oncology reports 2021 Nov;46(5)
Sanguinarine impairs lysosomal function and induces ROS-dependent mitophagy and apoptosis in human hepatocellular carcinoma cells.
Wang J, Su Q, Wu Q, Chen K, Ullah A, Ghauri MA, Zhang Y
Archives of pharmacal research 2021 Nov;44(11):1025-1036
Archives of pharmacal research 2021 Nov;44(11):1025-1036
Low-dose exposure to black carbon significantly increase lung injury of cadmium by promoting cellular apoptosis.
Wang L, Bao S, Liu X, Wang F, Zhang J, Dang P, Wang F, Li B, Lin Y
Ecotoxicology and environmental safety 2021 Nov;224:112703
Ecotoxicology and environmental safety 2021 Nov;224:112703
Effect of long-term exposure to acrylamide on endoplasmic reticulum stress and autophagy in rat cerebellum.
Wang Y, Duan L, Zhang X, Jiao Y, Liu Y, Dai L, Yan H
Ecotoxicology and environmental safety 2021 Nov;224:112691
Ecotoxicology and environmental safety 2021 Nov;224:112691
Anthocyanin from purple sweet potato attenuates lead-induced reproductive toxicity mediated by JNK signaling pathway in male mice.
Zhou L, Zhang C, Qiang Y, Huang M, Ren X, Li Y, Shao J, Xu L
Ecotoxicology and environmental safety 2021 Nov;224:112683
Ecotoxicology and environmental safety 2021 Nov;224:112683
EGFR and ERK activation resists flavonoid quercetin-induced anticancer activities in human cervical cancer cells in vitro.
Chen X, Xu P, Zhang H, Su X, Guo L, Zhou X, Wang J, Huang P, Zhang Q, Sun R
Oncology letters 2021 Nov;22(5):754
Oncology letters 2021 Nov;22(5):754
Anticancer roles of let-7f-1-3p in non-small cell lung cancer via direct targeting of integrin β1.
Yang Y, Liu Y, Xie N, Shao L, Sun H, Wei Y, Sun Y, Wang P, Yan Y, Xie S, Li Y
Experimental and therapeutic medicine 2021 Nov;22(5):1305
Experimental and therapeutic medicine 2021 Nov;22(5):1305
miR-378d is Involved in the Regulation of Apoptosis and Autophagy of and E(2) Secretion from Cultured Ovarian Granular Cells Treated by Sodium Fluoride.
Chen Q, Li Z, Xu Z, Chen C, Wang J, Zhu J, Dong Z
Biological trace element research 2021 Nov;199(11):4119-4128
Biological trace element research 2021 Nov;199(11):4119-4128
The anti-neoplastic activities of aloperine in HeLa cervical cancer cells are associated with inhibition of the IL-6-JAK1-STAT3 feedback loop.
Chen YD, Cai FY, Mao YZ, Yang YS, Xu K, Liu XF, Fan WW, Chen W, Jiang FQ, Zhang H
Chinese journal of natural medicines 2021 Nov;19(11):815-824
Chinese journal of natural medicines 2021 Nov;19(11):815-824
INHBA transfection regulates proliferation, apoptosis and hormone synthesis in sheep granulosa cells.
Bao Y, Yao X, Li X, Ei-Samahy MA, Yang H, Liang Y, Liu Z, Wang F
Theriogenology 2021 Nov;175:111-122
Theriogenology 2021 Nov;175:111-122
Sesamin promotes apoptosis and pyroptosis via autophagy to enhance antitumour effects on murine T-cell lymphoma.
Meng Z, Liu H, Zhang J, Zheng Z, Wang Z, Zhang L, Jia Z, Sui Y
Journal of pharmacological sciences 2021 Nov;147(3):260-270
Journal of pharmacological sciences 2021 Nov;147(3):260-270
The inhibitory effect Polygonum Cillinerve polysaccharide on transmissible gastroenteritis virus of swine.
Pan X, Zhou Y, Duan X, Cui J, Liu J, Song X, Ma W, Zhang W, Liu Y, Fan Y
Research in veterinary science 2021 Nov;140:47-55
Research in veterinary science 2021 Nov;140:47-55
DOC-2/DAB2 interactive protein destabilizes c-Myc to impair the growth and self-renewal of colon tumor-repopulating cells.
Li H, Zhou Y, Wang M, Wang H, Zhang Y, Peng R, Zhang R, Zhang M, Zhang M, Qiu P, Liu L, Zhao Q, Liu J
Cancer science 2021 Nov;112(11):4593-4603
Cancer science 2021 Nov;112(11):4593-4603
Betaine alleviates right ventricular failure via regulation of Rho A/ROCK signaling pathway in rats with pulmonary arterial hypertension.
Lv Y, Ma P, Wang J, Xu Q, Fan J, Yan L, Ma P, Zhou R
European journal of pharmacology 2021 Nov 5;910:174311
European journal of pharmacology 2021 Nov 5;910:174311
Taxifolin retards the D-galactose-induced aging process through inhibiting Nrf2-mediated oxidative stress and regulating the gut microbiota in mice.
Liu XL, Zhao YC, Zhu HY, Wu M, Zheng YN, Yang M, Cheng ZQ, Ding CB, Liu WC
Food & function 2021 Nov 29;12(23):12142-12158
Food & function 2021 Nov 29;12(23):12142-12158
Tβ4 ameliorates oxidative damage and apoptosis through ERK/MAPK and 5-HT1A signaling pathway in Aβ insulted SH-SY5Y cells.
Zhang GH, Pare RB, Chin KL, Qian YH
Life sciences 2021 Nov 25;:120178
Life sciences 2021 Nov 25;:120178
Maternal selenium deficiency suppresses proliferation, induces autophagy dysfunction and apoptosis in the placenta of mice.
Li M, Cheng W, Zhang L
Metallomics : integrated biometal science 2021 Nov 19;13(11)
Metallomics : integrated biometal science 2021 Nov 19;13(11)
3-Epipachysamine B suppresses proliferation and induces apoptosis of breast cancer cell via PI3K/AKT/mTOR signaling pathway.
Zhang L, Zheng Y, Zeng L, Zhang F, Che D, Cao Z, Huang C, Xian L, Zhang X, Zhang H, Guo Z
Life sciences 2021 Nov 15;285:119995
Life sciences 2021 Nov 15;285:119995
Changes in histology, protein expression, and autophagy in dairy goat testes during nonbreeding season†.
Xi H, Ren F, Li Y, Du Y, Wang L, Hu J
Biology of reproduction 2021 Nov 15;105(5):1344-1354
Biology of reproduction 2021 Nov 15;105(5):1344-1354
CDKN2B antisense RNA 1 suppresses tumor growth in human colorectal cancer by targeting MAPK inactivator dual-specificity phosphatase 1.
Pan J, Lin M, Xu Z, Xu M, Zhang J, Weng Z, Lin B, Lin X
Carcinogenesis 2021 Nov 12;42(11):1399-1409
Carcinogenesis 2021 Nov 12;42(11):1399-1409
Melatonin enhances SIRT1 to ameliorate mitochondrial membrane damage by activating PDK1/Akt in granulosa cells of PCOS.
Zheng B, Meng J, Zhu Y, Ding M, Zhang Y, Zhou J
Journal of ovarian research 2021 Nov 11;14(1):152
Journal of ovarian research 2021 Nov 11;14(1):152
TGIF1 plays a carcinogenic role in esophageal squamous cell carcinoma through the Wnt/β‑catenin and Akt/mTOR signaling pathways.
Kong L, Yu Y, Guan H, Jiang L, Sun F, Li X, Huang W, Li B
International journal of molecular medicine 2021 May;47(5)
International journal of molecular medicine 2021 May;47(5)
Mzb1 protects against myocardial infarction injury in mice via modulating mitochondrial function and alleviating inflammation.
Zhang L, Wang YN, Ju JM, Shabanova A, Li Y, Fang RN, Sun JB, Guo YY, Jin TZ, Liu YY, Li TY, Shan HL, Liang HH, Yang BF
Acta pharmacologica Sinica 2021 May;42(5):691-700
Acta pharmacologica Sinica 2021 May;42(5):691-700
TUFM is involved in Alzheimer's disease-like pathologies that are associated with ROS.
Zhong BR, Zhou GF, Song L, Wen QX, Deng XJ, Ma YL, Hu LT, Chen GJ
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 May;35(5):e21445
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 May;35(5):e21445
Chlorogenic acid enhances autophagy by upregulating lysosomal function to protect against SH-SY5Y cell injury induced by H(2)O(2).
Gao LJ, Dai Y, Li XQ, Meng S, Zhong ZQ, Xu SJ
Experimental and therapeutic medicine 2021 May;21(5):426
Experimental and therapeutic medicine 2021 May;21(5):426
Expression and prognostic value of E2F3 transcription factor in non-small cell lung cancer.
Wu L, Wan S, Li J, Xu Y, Lou X, Sun M, Wang S
Oncology letters 2021 May;21(5):411
Oncology letters 2021 May;21(5):411
Effects of SPATA6 on proliferation, apoptosis and steroidogenesis of Hu sheep Leydig cells in vitro.
Li X, Yao X, Xie H, Deng M, Gao X, Deng K, Bao Y, Wang Q, Wang F
Theriogenology 2021 May;166:9-20
Theriogenology 2021 May;166:9-20
Mitochondrial TXN2 attenuates amyloidogenesis via selective inhibition of BACE1 expression.
Li KY, Xiang XJ, Song L, Chen J, Luo B, Wen QX, Zhong BR, Zhou GF, Deng XJ, Ma YL, Hu LT, Chen GJ
Journal of neurochemistry 2021 May;157(4):1351-1365
Journal of neurochemistry 2021 May;157(4):1351-1365
The Kidney-Related Effects of Polystyrene Microplastics on Human Kidney Proximal Tubular Epithelial Cells HK-2 and Male C57BL/6 Mice.
Wang YL, Lee YH, Hsu YH, Chiu IJ, Huang CC, Huang CC, Chia ZC, Lee CP, Lin YF, Chiu HW
Environmental health perspectives 2021 May;129(5):57003
Environmental health perspectives 2021 May;129(5):57003
SEC61G promotes breast cancer development and metastasis via modulating glycolysis and is transcriptionally regulated by E2F1.
Ma J, He Z, Zhang H, Zhang W, Gao S, Ni X
Cell death & disease 2021 May 27;12(6):550
Cell death & disease 2021 May 27;12(6):550
Verapamil inhibits early acute liver failure through suppressing the NLRP3 inflammasome pathway.
Han M, Li S, Li L
Journal of cellular and molecular medicine 2021 May 24;25(13):5963-75
Journal of cellular and molecular medicine 2021 May 24;25(13):5963-75
Molecular landscape and subtype-specific therapeutic response of nasopharyngeal carcinoma revealed by integrative pharmacogenomics.
Ding RB, Chen P, Rajendran BK, Lyu X, Wang H, Bao J, Zeng J, Hao W, Sun H, Wong AH, Valecha MV, Yang EJ, Su SM, Choi TK, Liu S, Chan KI, Yang LL, Wu J, Miao K, Chen Q, Shim JS, Xu X, Deng CX
Nature communications 2021 May 24;12(1):3046
Nature communications 2021 May 24;12(1):3046
Interleukin-17 aggravates right ventricular remodeling via activating STAT3 under both normoxia and hypoxia.
Huang J, Zhang W, Zhang CL, Wang L
BMC cardiovascular disorders 2021 May 21;21(1):249
BMC cardiovascular disorders 2021 May 21;21(1):249
[Development and functional validation of a nano-delivery system of miR-16/polypeptide targeting ovarian cancer cells].
Li Q, Cen B, Huang W, Chen J, Chen Z, Pang J, Fu W, He S, Ji A
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2021 May 20;41(5):736-746
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2021 May 20;41(5):736-746
LncRNA CD27-AS1 promotes acute myeloid leukemia progression through the miR-224-5p/PBX3 signaling circuit.
Tao Y, Zhang J, Chen L, Liu X, Yao M, Zhang H
Cell death & disease 2021 May 18;12(6):510
Cell death & disease 2021 May 18;12(6):510
Protective effect of recombinant Lactobacillus plantarum against H(2)O(2)-induced oxidative stress in HUVEC cells.
Wang G, Hao M, Liu Q, Jiang Y, Huang H, Yang G, Wang C
Journal of Zhejiang University. Science. B 2021 May 15;22(5):348-365
Journal of Zhejiang University. Science. B 2021 May 15;22(5):348-365
Loss of Camk2n1 aggravates cardiac remodeling and malignant ventricular arrhythmia after myocardial infarction in mice via NLRP3 inflammasome activation.
Wei Z, Fei Y, Wang Q, Hou J, Cai X, Yang Y, Chen T, Xu Q, Wang Y, Li YG
Free radical biology & medicine 2021 May 1;167:243-257
Free radical biology & medicine 2021 May 1;167:243-257
The HDAC and PI3K dual inhibitor CUDC-907 synergistically enhances the antileukemic activity of venetoclax in preclinical models of acute myeloid leukemia.
Li X, Su Y, Hege K, Madlambayan G, Edwards H, Knight T, Polin L, Kushner J, Dzinic SH, White K, Yang J, Miller R, Wang G, Zhao L, Wang Y, Lin H, Taub JW, Ge Y
Haematologica 2021 May 1;106(5):1262-1277
Haematologica 2021 May 1;106(5):1262-1277
Valproic acid mitigates spinal nerve ligation-induced neuropathic pain in rats by modulating microglial function and inhibiting neuroinflammatory response.
Guo A, Li J, Luo L, Chen C, Lu Q, Ke J, Feng X
International immunopharmacology 2021 Mar;92:107332
International immunopharmacology 2021 Mar;92:107332
Decreased miR-214-3p activates NF-κB pathway and aggravates osteoarthritis progression.
Cao Y, Tang S, Nie X, Zhou Z, Ruan G, Han W, Zhu Z, Ding C
EBioMedicine 2021 Mar;65:103283
EBioMedicine 2021 Mar;65:103283
Chlorogenic acid inhibits proliferation in human hepatoma cells by suppressing noncanonical NF-κB signaling pathway and triggering mitochondrial apoptosis.
Jiang Y, Nan H, Shi N, Hao W, Dong J, Chen H
Molecular biology reports 2021 Mar;48(3):2351-2364
Molecular biology reports 2021 Mar;48(3):2351-2364
Inhibition of chondrocyte apoptosis in a rat model of osteoarthritis by exosomes derived from miR‑140‑5p‑overexpressing human dental pulp stem cells.
Lin T, Wu N, Wang L, Zhang R, Pan R, Chen YF
International journal of molecular medicine 2021 Mar;47(3)
International journal of molecular medicine 2021 Mar;47(3)
Cordyceps acid alleviates lung cancer in nude mice.
Wang J, Chen H, Li W, Shan L
Journal of biochemical and molecular toxicology 2021 Mar;35(3):e22670
Journal of biochemical and molecular toxicology 2021 Mar;35(3):e22670
Apoptosis inhibition is involved in improvement of sevoflurane-induced cognitive impairment following normobaric hyperoxia preconditioning in aged rats.
Wang Y, Yin CP, Tai YL, Zhao ZJ, Hou ZY, Wang QJ
Experimental and therapeutic medicine 2021 Mar;21(3):203
Experimental and therapeutic medicine 2021 Mar;21(3):203
Nuciferine protects against folic acid-induced acute kidney injury by inhibiting ferroptosis.
Li D, Liu B, Fan Y, Liu M, Han B, Meng Y, Xu X, Song Z, Liu X, Hao Q, Duan X, Nakai A, Chang Y, Cao P, Tan K
British journal of pharmacology 2021 Mar;178(5):1182-1199
British journal of pharmacology 2021 Mar;178(5):1182-1199
Three phytosterols from sweet potato inhibit MCF7-xenograft-tumor growth through modulating gut microbiota homeostasis and SCFAs secretion.
Han B, Jiang P, Jiang L, Li X, Ye X
Food research international (Ottawa, Ont.) 2021 Mar;141:110147
Food research international (Ottawa, Ont.) 2021 Mar;141:110147
Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway.
Gao X, Wang Y, Lu F, Chen X, Yang D, Cao Y, Zhang W, Chen J, Zheng L, Wang G, Fu M, Ma L, Song Y, Zhan Q
Journal of extracellular vesicles 2021 Mar;10(5):e12060
Journal of extracellular vesicles 2021 Mar;10(5):e12060
miR-98-5p protects against cerebral ischemia/reperfusion injury through anti-apoptosis and anti-oxidative stress in mice.
Yu S, Zhai J, Yu J, Yang Q, Yang J
Journal of biochemistry 2021 Mar 5;169(2):195-206
Journal of biochemistry 2021 Mar 5;169(2):195-206
PGC1α Promotes Cisplatin Resistance in Ovarian Cancer by Regulating the HSP70/HK2/VDAC1 Signaling Pathway.
Li Y, Kang J, Fu J, Luo H, Liu Y, Li Y, Sun L
International journal of molecular sciences 2021 Mar 3;22(5)
International journal of molecular sciences 2021 Mar 3;22(5)
CircRNA RSF1 regulated ox-LDL induced vascular endothelial cells proliferation, apoptosis and inflammation through modulating miR-135b-5p/HDAC1 axis in atherosclerosis.
Zhang X, Lu J, Zhang Q, Luo Q, Liu B
Biological research 2021 Mar 23;54(1):11
Biological research 2021 Mar 23;54(1):11
Inhibition of lipogenesis and induction of apoptosis by valproic acid in prostate cancer cells via the C/EBPα/SREBP-1 pathway.
Pang B, Zhang J, Zhang X, Yuan J, Shi Y, Qiao L
Acta biochimica et biophysica Sinica 2021 Mar 2;53(3):354-364
Acta biochimica et biophysica Sinica 2021 Mar 2;53(3):354-364
MiR-133a-3p relieves the oxidative stress induced trophoblast cell apoptosis through the BACH1/Nrf2/HO-1 signaling pathway.
Guo H, Wang Y, Jia W, Liu L
Physiological research 2021 Mar 17;70(1):67-78
Physiological research 2021 Mar 17;70(1):67-78
The role of Se content in improving anti-tumor activities and its potential mechanism for selenized Artemisia sphaerocephala polysaccharides.
Liu S, Hu J, Li M, Zhu S, Guo S, Guo H, Wang T, Zhang Y, Zhang J, Wang J
Food & function 2021 Mar 15;12(5):2058-2074
Food & function 2021 Mar 15;12(5):2058-2074
α-Solanine Inhibits Proliferation, Invasion, and Migration, and Induces Apoptosis in Human Choriocarcinoma JEG-3 Cells In Vitro and In Vivo.
Gu T, Yuan W, Li C, Chen Z, Wen Y, Zheng Q, Yang Q, Xiong X, Yuan A
Toxins 2021 Mar 13;13(3)
Toxins 2021 Mar 13;13(3)
Sesamin induces cell cycle arrest and apoptosis through p38/C-Jun N-terminal kinase mitogen-activated protein kinase pathways in human colorectal cancer cells.
Wang X, Qiao J, Zou C, Zhao Y, Huang Y
Anti-cancer drugs 2021 Mar 1;32(3):248-256
Anti-cancer drugs 2021 Mar 1;32(3):248-256
Identifying miRNAs in multiple sclerosis gray matter lesions that correlate with atrophy measures.
Tripathi A, Pandit I, Perles A, Zhou Y, Cheng F, Dutta R
Annals of clinical and translational neurology 2021 Jun;8(6):1279-1291
Annals of clinical and translational neurology 2021 Jun;8(6):1279-1291
WISP-1 induced by mechanical stress contributes to fibrosis and hypertrophy of the ligamentum flavum through Hedgehog-Gli1 signaling.
Sun C, Ma Q, Yin J, Zhang H, Liu X
Experimental & molecular medicine 2021 Jun;53(6):1068-1079
Experimental & molecular medicine 2021 Jun;53(6):1068-1079
Drug-repositioning screening identified fludarabine and risedronic acid as potential therapeutic compounds for malignant pleural mesothelioma.
Dell'Anno I, Martin SA, Barbarino M, Melani A, Silvestri R, Bottaro M, Paolicchi E, Corrado A, Cipollini M, Melaiu O, Giordano A, Luzzi L, Gemignani F, Landi S
Investigational new drugs 2021 Jun;39(3):644-657
Investigational new drugs 2021 Jun;39(3):644-657
Temperature Variability Does Not Attenuate the Beneficial Effects of Therapeutic Hypothermia on Cellular Apoptosis and Endoplasmic Reticulum Stress in the Cerebral Cortex of a Swine Cardiac Arrest Model.
Zhang B, Gu Q, Chen X, You Y, Chen M, Qian Y, Chen Y, Yu W
Neurocritical care 2021 Jun;34(3):769-780
Neurocritical care 2021 Jun;34(3):769-780
PIWIL2 interacting with IKK to regulate autophagy and apoptosis in esophageal squamous cell carcinoma.
Zhao X, Huang L, Lu Y, Jiang W, Song Y, Qiu B, Tao D, Liu Y, Ma Y
Cell death and differentiation 2021 Jun;28(6):1941-1954
Cell death and differentiation 2021 Jun;28(6):1941-1954
Wogonin alleviates liver injury in sepsis through Nrf2-mediated NF-κB signalling suppression.
Dai JM, Guo WN, Tan YZ, Niu KW, Zhang JJ, Liu CL, Yang XM, Tao KS, Chen ZN, Dai JY
Journal of cellular and molecular medicine 2021 Jun;25(12):5782-5798
Journal of cellular and molecular medicine 2021 Jun;25(12):5782-5798
Ketoplatin in triple-negative breast cancer cells MDA-MB-231: High efficacy and low toxicity, and positive impact on inflammatory microenvironment.
Ma ZY, Song XQ, Hu JJ, Wang DB, Ding XJ, Liu RP, Dai ML, Meng FY, Xu JY
Biochemical pharmacology 2021 Jun;188:114523
Biochemical pharmacology 2021 Jun;188:114523
Mir-34c affects the proliferation and pluripotency of porcine induced pluripotent stem cell (piPSC)-like cells by targeting c-Myc.
Yue W, Sun J, Zhang J, Chang Y, Shen Q, Zhu Z, Yu S, Wu X, Peng S, Li N, Hua J
Cells & development 2021 Jun;166:203665
Cells & development 2021 Jun;166:203665
AMD3465 (hexahydrobromide) rescues the MG63 osteoblasts against the apoptosis induced by high glucose.
Zhang Z, Wu H, Huang S, Chen L, Chen X, Zhang W, Liao L, Zhang X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111476
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111476
Effect of SOCS3 on apoptosis of human trophoblasts via adjustment of the JAK2/STAT3 signaling pathway in preterm birth.
Yin Y, Qu L, Zhu D, Wu Y, Zhou X
Translational pediatrics 2021 Jun;10(6):1637-1646
Translational pediatrics 2021 Jun;10(6):1637-1646
YWHAE as an HE4 interacting protein can influence the malignant behaviour of ovarian cancer by regulating the PI3K/AKT and MAPK pathways.
Li X, Wang C, Wang S, Hu Y, Jin S, Liu O, Gou R, Nie X, Liu J, Lin B
Cancer cell international 2021 Jun 9;21(1):302
Cancer cell international 2021 Jun 9;21(1):302
Cellular FADD-like IL-1β-converting enzyme-inhibitory protein attenuates myocardial ischemia/reperfusion injury via suppressing apoptosis and autophagy simultaneously.
Liu D, Wu H, Li YZ, Yang J, Yang J, Ding JW, Zhou G, Zhang J, Wang X, Fan ZX
Nutrition, metabolism, and cardiovascular diseases : NMCD 2021 Jun 7;31(6):1916-1928
Nutrition, metabolism, and cardiovascular diseases : NMCD 2021 Jun 7;31(6):1916-1928
The combination of CUDC-907 and gilteritinib shows promising in vitro and in vivo antileukemic activity against FLT3-ITD AML.
Qiao X, Ma J, Knight T, Su Y, Edwards H, Polin L, Li J, Kushner J, Dzinic SH, White K, Wang J, Lin H, Wang Y, Wang L, Wang G, Taub JW, Ge Y
Blood cancer journal 2021 Jun 7;11(6):111
Blood cancer journal 2021 Jun 7;11(6):111
Effects of β-Asarone on Ischemic Stroke in Middle Cerebral Artery Occlusion Rats by an Nrf2-Antioxidant Response Elements (ARE) Pathway-Dependent Mechanism.
Pan H, Xu Y, Cai Q, Wu M, Ding M
Medical science monitor : international medical journal of experimental and clinical research 2021 Jun 4;27:e931884
Medical science monitor : international medical journal of experimental and clinical research 2021 Jun 4;27:e931884
Hypoxia induces chemoresistance of esophageal cancer cells to cisplatin through regulating the lncRNA-EMS/miR-758-3p/WTAP axis.
Zhu ZJ, Pang Y, Jin G, Zhang HY, Wang WH, Liu JW, Tuo GX, Wu P, Yang Y, Wang ZQ, Wang K
Aging 2021 Jun 3;13(13):17155-17176
Aging 2021 Jun 3;13(13):17155-17176
Anti-tumor effects of Solanum nigrum L. extraction on C6 high-grade glioma.
Li JH, Li SY, Shen MX, Qiu RZ, Fan HW, Li YB
Journal of ethnopharmacology 2021 Jun 28;274:114034
Journal of ethnopharmacology 2021 Jun 28;274:114034
Long noncoding RNA LINC00284 facilitates cell proliferation in papillary thyroid cancer via impairing miR-3127-5p targeted E2F7 suppression.
Zhou B, Ge Y, Shao Q, Yang L, Chen X, Jiang G
Cell death discovery 2021 Jun 26;7(1):156
Cell death discovery 2021 Jun 26;7(1):156
DNA methylation mediated RSPO2 to promote follicular development in mammals.
Zhou X, He Y, Li N, Bai G, Pan X, Zhang Z, Zhang H, Li J, Yuan X
Cell death & disease 2021 Jun 26;12(7):653
Cell death & disease 2021 Jun 26;12(7):653
DUSP1 overexpression attenuates renal tubular mitochondrial dysfunction by restoring Parkin-mediated mitophagy in diabetic nephropathy.
Lu C, Wu B, Liao Z, Xue M, Zou Z, Feng J, Sheng J
Biochemical and biophysical research communications 2021 Jun 25;559:141-147
Biochemical and biophysical research communications 2021 Jun 25;559:141-147
VHL regulates the sensitivity of clear cell renal cell carcinoma to SIRT4-mediated metabolic stress via HIF-1α/HO-1 pathway.
Tong Y, Kai J, Wang S, Yu Y, Xie S, Zheng H, Wang Y, Liu Y, Zhu K, Guan X, Guo L, Lu R
Cell death & disease 2021 Jun 16;12(7):621
Cell death & disease 2021 Jun 16;12(7):621
NPRL2 reduces the niraparib sensitivity of castration-resistant prostate cancer via interacting with UBE2M and enhancing neddylation.
Zhao X, Jiang L, Hu D, Tang Y, Zhao G, Du X, Luo S, Tang W
Experimental cell research 2021 Jun 15;403(2):112614
Experimental cell research 2021 Jun 15;403(2):112614
Bone marrow-derived mesenchymal stem cells attenuate silica-induced pulmonary fibrosis by inhibiting apoptosis and pyroptosis but not autophagy in rats.
Zhao Q, Hao C, Wei J, Huang R, Li C, Yao W
Ecotoxicology and environmental safety 2021 Jun 15;216:112181
Ecotoxicology and environmental safety 2021 Jun 15;216:112181
Helenalin Facilitates Reactive Oxygen Species-Mediated Apoptosis and Cell Cycle Arrest by Targeting Thioredoxin Reductase-1 in Human Prostate Cancer Cells.
Yang M, Zhang W, Yu X, Wang F, Li Y, Zhang Y, Yang Y
Medical science monitor : international medical journal of experimental and clinical research 2021 Jun 14;27:e930083
Medical science monitor : international medical journal of experimental and clinical research 2021 Jun 14;27:e930083
The Long-Term DEHP Exposure Confers Multidrug Resistance of Triple-Negative Breast Cancer Cells through ABC Transporters and Intracellular ROS.
Jadhao M, Tsai EM, Yang HC, Chen YF, Liang SS, Wang TN, Teng YN, Huang HW, Wang LF, Chiu CC
Antioxidants (Basel, Switzerland) 2021 Jun 11;10(6)
Antioxidants (Basel, Switzerland) 2021 Jun 11;10(6)
A neutral polysaccharide from Ophiocordyceps lanpingensis restrains cisplatin-induced nephrotoxicity.
Zhou S, Zhou Y, Yu J, Jiang L, Xiang Y, Wang J, Du Y, Cui X, Ge F
Food science & nutrition 2021 Jul;9(7):3602-3616
Food science & nutrition 2021 Jul;9(7):3602-3616
Electroacupuncture at GV20‑GB7 regulates mitophagy to protect against neurological deficits following intracerebral hemorrhage via inhibition of apoptosis.
Guan R, Li Z, Dai X, Zou W, Yu X, Liu H, Chen Q, Teng W, Liu P, Liu X, Dong S
Molecular medicine reports 2021 Jul;24(1)
Molecular medicine reports 2021 Jul;24(1)
2-Methoxyestradiol synergizes with Erlotinib to suppress hepatocellular carcinoma by disrupting the PLAGL2-EGFR-HIF-1/2α signaling loop.
Zheng S, Ni J, Li Y, Lu M, Yao Y, Guo H, Jiao M, Jin T, Zhang H, Yuan A, Wang Z, Yang Y, Chen Z, Wu H, Hu W
Pharmacological research 2021 Jul;169:105685
Pharmacological research 2021 Jul;169:105685
LncRNA TONSL-AS1 participates in coronary artery disease by interacting with miR-197.
Wu L, Tan G, Li X, Jiang X, Run B, Zhou W, Liao H
Microvascular research 2021 Jul;136:104152
Microvascular research 2021 Jul;136:104152
Choline attenuates heat stress-induced oxidative injury and apoptosis in bovine mammary epithelial cells by modulating PERK/Nrf-2 signaling pathway.
Yang M, Kuang M, Wang G, Ali I, Tang Y, Yang C, Li Y, Li L
Molecular immunology 2021 Jul;135:388-397
Molecular immunology 2021 Jul;135:388-397
Amyloid-β (25-35) regulates neuronal damage and memory loss via SIRT1/Nrf2 in the cortex of mice.
Zhu L, Lu F, Jia X, Yan Q, Zhang X, Mu P
Journal of chemical neuroanatomy 2021 Jul;114:101945
Journal of chemical neuroanatomy 2021 Jul;114:101945
Anti-CD19 mAb modified mesoporous titanium dioxide as exclusively targeting vector for efficient B-lymphoblastic leukemia therapy.
Li S, Zhang L, Li M, Huang J, Cui B, Jia J, Guo Z, Ma K, Cui C
Journal of pharmaceutical sciences 2021 Jul;110(7):2733-2742
Journal of pharmaceutical sciences 2021 Jul;110(7):2733-2742
Tubeimoside I improves endothelial function in sepsis via activation of SIRT3.
Yang X, Li X, Luo M, Li C, Huang L, Li X, Huang B, Shen J, Luo S, Yan J
Laboratory investigation; a journal of technical methods and pathology 2021 Jul;101(7):897-907
Laboratory investigation; a journal of technical methods and pathology 2021 Jul;101(7):897-907
Andrographolide Attenuates Gut-Brain-Axis Associated Pathology in Gulf War Illness by Modulating Bacteriome-Virome Associated Inflammation and Microglia-Neuron Proinflammatory Crosstalk.
Saha P, Skidmore PT, Holland LA, Mondal A, Bose D, Seth RK, Sullivan K, Janulewicz PA, Horner R, Klimas N, Nagarkatti M, Nagarkatti P, Lim ES, Chatterjee S
Brain sciences 2021 Jul 9;11(7)
Brain sciences 2021 Jul 9;11(7)
Prognostic signature composed of transcription factors accurately predicts the prognosis of gastric cancer patients.
Zhou L, Chen Z, Wu Y, Lu H, Xin L
Cancer cell international 2021 Jul 7;21(1):357
Cancer cell international 2021 Jul 7;21(1):357
Glycoursodeoxycholic acid ameliorates diet-induced metabolic disorders with inhibiting endoplasmic reticulum stress.
Cheng L, Chen T, Guo M, Liu P, Qiao X, Wei Y, She J, Li B, Xi W, Zhou J, Yuan Z, Wu Y, Liu J
Clinical science (London, England : 1979) 2021 Jul 30;135(14):1689-1706
Clinical science (London, England : 1979) 2021 Jul 30;135(14):1689-1706
miR-126 Controls the Apoptosis and Proliferation of Immature Porcine Sertoli Cells by Targeting the PIK3R2 Gene through the PI3K/AKT Signaling Pathway.
Tang X, Chen Y, Luo H, Bian Q, Weng B, Yang A, Chu D, Ran M, Chen B
Animals : an open access journal from MDPI 2021 Jul 30;11(8)
Animals : an open access journal from MDPI 2021 Jul 30;11(8)
A novel chemical inhibitor suppresses breast cancer cell growth and metastasis through inhibiting HPIP oncoprotein.
Li P, Cao S, Huang Y, Zhang Y, Liu J, Cai X, Zhou L, Li J, Jiang Z, Ding L, Zheng Z, Li S, Ye Q
Cell death discovery 2021 Jul 29;7(1):198
Cell death discovery 2021 Jul 29;7(1):198
NUDCD1 knockdown inhibits the proliferation, migration, and invasion of pancreatic cancer via the EMT process.
Shi C, Weng M, Zhu H, Guo Y, Xu D, Jin H, Wei B, Cao Z
Aging 2021 Jul 29;13(14):18298-18309
Aging 2021 Jul 29;13(14):18298-18309
The anti-dysenteric drug fraxetin enhances anti-tumor efficacy of gemcitabine and suppresses pancreatic cancer development by antagonizing STAT3 activation.
Guo Y, Xiao Y, Guo H, Zhu H, Chen D, Wang J, Deng J, Lan J, Liu X, Zhang Q, Bai Y
Aging 2021 Jul 28;13(14):18545-18563
Aging 2021 Jul 28;13(14):18545-18563
A CREB1-miR-181a-5p loop regulates the pathophysiologic features of bone marrow stromal cells in fibrous dysplasia of bone.
Fu Y, Xin Z, Ling Z, Xie H, Xiao T, Shen X, Lin J, Xu L, Jiang H
Molecular medicine (Cambridge, Mass.) 2021 Jul 22;27(1):81
Molecular medicine (Cambridge, Mass.) 2021 Jul 22;27(1):81
VALD-3, a Schiff base ligand synthesized from o-vanillin derivatives, induces cell cycle arrest and apoptosis in breast cancer cells by inhibiting the Wnt/β-catenin pathway.
Li H, Dang C, Tai X, Xue L, Meng Y, Ma S, Zhang J
Scientific reports 2021 Jul 22;11(1):14985
Scientific reports 2021 Jul 22;11(1):14985
Long noncoding RNA GAS5 accelerates diabetic wound healing and promotes lymphangiogenesis via miR-217/Prox1 axis.
He ZY, Huang MT, Cui X, Zhou ST, Wu Y, Zhang PH, Zhou J
Molecular and cellular endocrinology 2021 Jul 15;532:111283
Molecular and cellular endocrinology 2021 Jul 15;532:111283
Early-senescent bone marrow mesenchymal stem cells promote C2C12 cell myogenic differentiation by preventing the nuclear translocation of FOXO3.
Che J, Xu C, Wu Y, Jia P, Han Q, Ma Y, Wang X, Du Y, Zheng Y
Life sciences 2021 Jul 15;277:119520
Life sciences 2021 Jul 15;277:119520
Antagonistic effect of nano-selenium on hepatocyte apoptosis induced by DEHP via PI3K/AKT pathway in chicken liver.
Li H, Zhang J, Xia Y, Pan W, Zhou D
Ecotoxicology and environmental safety 2021 Jul 15;218:112282
Ecotoxicology and environmental safety 2021 Jul 15;218:112282
Limonin ameliorates dextran sulfate sodium-induced chronic colitis in mice by inhibiting PERK-ATF4-CHOP pathway of ER stress and NF-κB signaling.
Song C, Chen J, Li X, Yang R, Cao X, Zhou L, Zhou Y, Ying H, Zhang Q, Sun Y
International immunopharmacology 2021 Jan;90:107161
International immunopharmacology 2021 Jan;90:107161
Antileukemic effect of caffeic acid 3,4-dihydroxyphenetyl ester. Evidences for its mechanisms of action.
Tang M, Xie X, Shi M, Xin W, Zheng G, Zhang Y, Zhang Z, Lian X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Jan;80:153383
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Jan;80:153383
BCL2 enhances survival of porcine pluripotent stem cells through promoting FGFR2.
Zhu Z, Pan Q, Zhao W, Wu X, Yu S, Shen Q, Zhang J, Yue W, Peng S, Li N, Zhang S, Lei A, Hua J
Cell proliferation 2021 Jan;54(1):e12932
Cell proliferation 2021 Jan;54(1):e12932
S100A8 promotes chemoresistance via augmenting autophagy in B‑cell lymphoma cells.
Zhang L, Zhou S, Zhou T, Yuan K, Li X, Tang J
Oncology reports 2021 Jan;45(1):151-158
Oncology reports 2021 Jan;45(1):151-158
Fangchinoline exerts antitumour activity by suppressing the EGFR‑PI3K/AKT signalling pathway in colon adenocarcinoma.
Jiang F, Ren S, Chen Y, Zhang A, Zhu Y, Zhang Z, Li Z, Piao D
Oncology reports 2021 Jan;45(1):139-150
Oncology reports 2021 Jan;45(1):139-150
FUNDC1-dependent mitophagy induced by tPA protects neurons against cerebral ischemia-reperfusion injury.
Cai Y, Yang E, Yao X, Zhang X, Wang Q, Wang Y, Liu J, Fan W, Yi K, Kang C, Wu J
Redox biology 2021 Jan;38:101792
Redox biology 2021 Jan;38:101792
Senolytic therapy ameliorates renal fibrosis postacute kidney injury by alleviating renal senescence.
Li C, Shen Y, Huang L, Liu C, Wang J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Jan;35(1):e21229
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Jan;35(1):e21229
Inhibition of Bcl-2 and Bcl-xL overcomes the resistance to the third-generation EGFR tyrosine kinase inhibitor osimertinib in non-small cell lung cancer.
Lu Y, Bian D, Zhang X, Zhang H, Zhu Z
Molecular medicine reports 2021 Jan;23(1)
Molecular medicine reports 2021 Jan;23(1)
Inhibition of proliferation-linked signaling cascades with atractylenolide I reduces myofibroblastic phenotype and renal fibrosis.
Guo Y, Xiao Y, Zhu H, Guo H, Zhou Y, Shentu Y, Zheng C, Chen C, Bai Y
Biochemical pharmacology 2021 Jan;183:114344
Biochemical pharmacology 2021 Jan;183:114344
The neuroprotective effects of phosphocreatine on Amyloid Beta 25-35-induced differentiated neuronal cell death through inhibition of AKT /GSK-3β /Tau/APP /CDK5 pathways in vivo and vitro.
Ai J, Wang H, Chu P, Shopit A, Niu M, Ahmad N, Tesfaldet T, Wang FH, Fang JN, Li X, Tang SJ, Qing Ju Han, Han G, Peng J, Tang Z
Free radical biology & medicine 2021 Jan;162:181-190
Free radical biology & medicine 2021 Jan;162:181-190
Triptolidenol, isolated from Tripterygium wilfordii, disrupted NF-κB/COX-2 pathway by targeting ATP-binding sites of IKKβ in clear cell renal cell carcinoma.
Jin J, Zhou M, Wang X, Liu M, Huang H, Yan F, Yu Z, Shu X, Huo X, Feng L, Zhang B, Huang S, Deng S, Wang C, Ma X
Fitoterapia 2021 Jan;148:104779
Fitoterapia 2021 Jan;148:104779
Toxicity of different zinc oxide nanomaterials and dose-dependent onset and development of Parkinson's disease-like symptoms induced by zinc oxide nanorods.
Jin M, Li N, Sheng W, Ji X, Liang X, Kong B, Yin P, Li Y, Zhang X, Liu K
Environment international 2021 Jan;146:106179
Environment international 2021 Jan;146:106179
Qingda granule attenuates angiotensin II-induced cardiac hypertrophy and apoptosis and modulates the PI3K/AKT pathway.
Cheng Y, Shen A, Wu X, Shen Z, Chen X, Li J, Liu L, Lin X, Wu M, Chen Y, Chu J, Peng J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jan;133:111022
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jan;133:111022
Lidocaine inhibits the metastatic potential of ovarian cancer by blocking Na(V) 1.5-mediated EMT and FAK/Paxillin signaling pathway.
Liu C, Yu M, Li Y, Wang H, Xu C, Zhang X, Li M, Guo H, Ma D, Guo X
Cancer medicine 2021 Jan;10(1):337-349
Cancer medicine 2021 Jan;10(1):337-349
Omeprazole improves chemosensitivity of gastric cancer cells by m6A demethylase FTO-mediated activation of mTORC1 and DDIT3 up-regulation.
Feng S, Qiu G, Yang L, Feng L, Fan X, Ren F, Huang K, Chen Y
Bioscience reports 2021 Jan 29;41(1)
Bioscience reports 2021 Jan 29;41(1)
Ameliorative effect of recombinant human lactoferrin on the premature ovarian failure in rats after cyclophosphamide treatments.
Li S, Liu M, Ma H, Jin Q, Ma Y, Wang C, Ren J, Liu G, Dai Y
Journal of ovarian research 2021 Jan 21;14(1):17
Journal of ovarian research 2021 Jan 21;14(1):17
Aloin protects mice from diet-induced non-alcoholic steatohepatitis via activation of Nrf2/HO-1 signaling.
Xu Q, Fan Y, Loor JJ, Liang Y, Lv H, Sun X, Jia H, Xu C
Food & function 2021 Jan 21;12(2):696-705
Food & function 2021 Jan 21;12(2):696-705
Cartilage endplate stem cells inhibit intervertebral disc degeneration by releasing exosomes to nucleus pulposus cells to activate Akt/autophagy.
Luo L, Jian X, Sun H, Qin J, Wang Y, Zhang J, Shen Z, Yang D, Li C, Zhao P, Liu M, Tian Z, Zhou Y
Stem cells (Dayton, Ohio) 2021 Jan 18;
Stem cells (Dayton, Ohio) 2021 Jan 18;
miR-31-5p promotes proliferation and inhibits apoptosis of goat hair follicle stem cells by targeting RASA1/MAP3K1 pathway.
Feng Y, Wang J, Ma J, Zhang L, Chu C, Hu H, Wang Y, Li Y
Experimental cell research 2021 Jan 15;398(2):112441
Experimental cell research 2021 Jan 15;398(2):112441
Adiponectin alleviates the symptoms of ischemic renal disease by inhibiting renal cell apoptosis.
Zheng X, Liu D
Life sciences 2021 Jan 15;265:118825
Life sciences 2021 Jan 15;265:118825
Shikonin differentially regulates glucose metabolism via PKM2 and HIF1α to overcome apoptosis in a refractory HCC cell line.
Yang W, Liu J, Hou L, Chen Q, Liu Y
Life sciences 2021 Jan 15;265:118796
Life sciences 2021 Jan 15;265:118796
Nephrotoxicity and possible mechanisms of decabrominated diphenyl ethers (BDE-209) exposure to kidney in broilers.
Sun S, Jin Y, Yang J, Zhao Z, Rao Q
Ecotoxicology and environmental safety 2021 Jan 15;208:111638
Ecotoxicology and environmental safety 2021 Jan 15;208:111638
Circ_0001438 participates in the pathogenesis of preeclampsia via the circ_0001438/miR-942/NLRP3 regulatory network.
Li X, Yang R, Xu Y, Zhang Y
Placenta 2021 Jan 15;104:40-50
Placenta 2021 Jan 15;104:40-50
MiR-133a-3p relieves the oxidative stress induced trophoblast cell apoptosis through the BACH1/Nrf2/HO-1 signaling pathway.
Guo H, Wang Y, Jia W, Liu L
Physiological research 2021 Jan 14;70(1)
Physiological research 2021 Jan 14;70(1)
LncRNA SNHG16 contributes to tumor progression via the miR-302b-3p/SLC2A4 axis in pancreatic adenocarcinoma.
Xu H, Miao X, Li X, Chen H, Zhang B, Zhou W
Cancer cell international 2021 Jan 12;21(1):51
Cancer cell international 2021 Jan 12;21(1):51
ALKBH5-mediated m(6)A demethylation of FOXM1 mRNA promotes progression of uveal melanoma.
Hao L, Yin J, Yang H, Li C, Zhu L, Liu L, Zhong J
Aging 2021 Jan 10;13(3):4045-4062
Aging 2021 Jan 10;13(3):4045-4062
PGC1α regulates mitochondrial oxidative phosphorylation involved in cisplatin resistance in ovarian cancer cells via nucleo-mitochondrial transcriptional feedback.
Shen L, Zhou L, Xia M, Lin N, Ma J, Dong D, Sun L
Experimental cell research 2021 Jan 1;398(1):112369
Experimental cell research 2021 Jan 1;398(1):112369
Deficiency of NEAT1 prevented MPP(+)-induced inflammatory response, oxidative stress and apoptosis in dopaminergic SK-N-SH neuroblastoma cells via miR-1277-5p/ARHGAP26 axis.
Zhou S, Zhang D, Guo J, Chen Z, Chen Y, Zhang J
Brain research 2021 Jan 1;1750:147156
Brain research 2021 Jan 1;1750:147156
Alantolactone induces apoptosis in THP-1 cells through STAT3, survivin inhibition, and intrinsic apoptosis pathway.
Ahmad B, Gamallat Y, Su P, Husain A, Rehman AU, Zaky MY, Bakheet AMH, Tahir N, Xin Y, Liang W
Chemical biology & drug design 2021 Feb;97(2):266-272
Chemical biology & drug design 2021 Feb;97(2):266-272
Bufarenogin induces intrinsic apoptosis via Bax and ANT cooperation.
Han Q, Zhang C, Zhang Y, Li Y, Wu L, Sun X
Pharmacology research & perspectives 2021 Feb;9(1):e00694
Pharmacology research & perspectives 2021 Feb;9(1):e00694
MicroRNA-520c-3p suppresses vascular endothelium dysfunction by targeting RELA and regulating the AKT and NF-κB signaling pathways.
Jiao Y, Zhao D, Gao F, Hu X, Hu X, Li M, Cui Y, Wei X, Xie C, Zhao Y, Gao Y
Journal of physiology and biochemistry 2021 Feb;77(1):47-61
Journal of physiology and biochemistry 2021 Feb;77(1):47-61
Curcumin Ameliorates Copper-Induced Neurotoxicity Through Inhibiting Oxidative Stress and Mitochondrial Apoptosis in SH-SY5Y Cells.
Xiang B, Li D, Chen Y, Li M, Zhang Y, Sun T, Tang S
Neurochemical research 2021 Feb;46(2):367-378
Neurochemical research 2021 Feb;46(2):367-378
Autophagy Induction Contributes to the Neuroprotective Impact of Intermittent Fasting on the Acutely Injured Spinal Cord.
Yuan W, He X, Morin D, Barrière G, Liu X, Li J, Zhu Y
Journal of neurotrauma 2021 Feb;38(3):373-384
Journal of neurotrauma 2021 Feb;38(3):373-384
Rosmarinic acid exerts an antagonistic effect on nonalcoholic fatty liver disease by regulating the YAP1/TAZ-PPARγ/PGC-1α signaling pathway.
Luo C, Sun H, Peng J, Gao C, Bao L, Ji R, Zhang C, Zhu W, Jin Y
Phytotherapy research : PTR 2021 Feb;35(2):1010-1022
Phytotherapy research : PTR 2021 Feb;35(2):1010-1022
PRSS55 plays an important role in the structural differentiation and energy metabolism of sperm and is required for male fertility in mice.
Zhu F, Li W, Zhou X, Chen X, Zheng M, Cui Y, Liu X, Guo X, Zhu H
Journal of cellular and molecular medicine 2021 Feb;25(4):2040-2051
Journal of cellular and molecular medicine 2021 Feb;25(4):2040-2051
Knockdown of long non‑coding RNA ANRIL inhibits the proliferation and promotes the apoptosis of Burkitt lymphoma cells through the TGF‑β1 signaling pathway.
Mao S, Jin J, Li Z, Yang W
Molecular medicine reports 2021 Feb;23(2)
Molecular medicine reports 2021 Feb;23(2)
CircCDK8 regulates osteogenic differentiation and apoptosis of PDLSCs by inducing ER stress/autophagy during hypoxia.
Zheng J, Zhu X, He Y, Hou S, Liu T, Zhi K, Hou T, Gao L
Annals of the New York Academy of Sciences 2021 Feb;1485(1):56-70
Annals of the New York Academy of Sciences 2021 Feb;1485(1):56-70
Impact of knockdown LincRNA-Cox2 on apoptosis of macrophage infected with Bacillus Calmette-Guérin.
Xu Y, Yu J, Ma C, Gong Z, Wu X, Deng G
Molecular immunology 2021 Feb;130:85-95
Molecular immunology 2021 Feb;130:85-95
RabGEF1 functions as an oncogene in U251 glioblastoma cells and is involved in regulating AKT and Erk pathways.
Fan H, Xin T, Dong X, Yang F, Zhang R, Feng S, He D, Guo H, Pang Q
Experimental and molecular pathology 2021 Feb;118:104571
Experimental and molecular pathology 2021 Feb;118:104571
RTN1-C mediates cerebral ischemia/reperfusion injury via modulating autophagy.
Ling J, Cai H, Lin M, Qi S, Du J, Chen L
Acta biochimica et biophysica Sinica 2021 Feb 4;53(2):170-178
Acta biochimica et biophysica Sinica 2021 Feb 4;53(2):170-178
The novel ZEB1-upregulated protein PRTG induced by Helicobacter pylori infection promotes gastric carcinogenesis through the cGMP/PKG signaling pathway.
Xiang T, Yuan C, Guo X, Wang H, Cai Q, Xiang Y, Luo W, Liu G
Cell death & disease 2021 Feb 4;12(2):150
Cell death & disease 2021 Feb 4;12(2):150
Central role of TRAP1 in the ameliorative effect of oleanolic acid on the mitochondrial-mediated and endoplasmic reticulum stress-excitated apoptosis induced by ochratoxin A.
Zhang Q, Chen W, Zhang B, Li C, Zhang X, Wang Q, Wang Y, Zhou Q, Li X, Shen XL
Toxicology 2021 Feb 28;450:152681
Toxicology 2021 Feb 28;450:152681
Transcription of MRPL12 regulated by Nrf2 contributes to the mitochondrial dysfunction in diabetic kidney disease.
Gu X, Liu Y, Wang N, Zhen J, Zhang B, Hou S, Cui Z, Wan Q, Feng H
Free radical biology & medicine 2021 Feb 20;164:329-340
Free radical biology & medicine 2021 Feb 20;164:329-340
Downregulation of CD151 induces oxidative stress and apoptosis in trophoblast cells via inhibiting ERK/Nrf2 signaling pathway in preeclampsia.
Wang Z, Cai B, Cao C, Lv H, Dai Y, Zheng M, Zhao G, Peng Y, Gou W, Wang J, Liu D, Hu Y
Free radical biology & medicine 2021 Feb 20;164:249-257
Free radical biology & medicine 2021 Feb 20;164:249-257
Rational design and synthesis of 6-aryl-6H-benzo[c]chromenes as non-steroidal progesterone receptor antagonists for use against cancers.
Qin J, Qu S, Zhu K, Cheng Y, Pan G, Jing W, Liu X, Sun X, Liu L
Bioorganic & medicinal chemistry 2021 Feb 15;32:116003
Bioorganic & medicinal chemistry 2021 Feb 15;32:116003
Protective effect of procyanidin A-type dimers against H(2)O(2)-induced oxidative stress in prostate DU145 cells through the MAPKs signaling pathway.
Yan F, Chen L, Chen W, Zhao L, Lu Q, Liu R
Life sciences 2021 Feb 1;266:118908
Life sciences 2021 Feb 1;266:118908
MEG3/MIR-376B-3P/HMGA2 axis is involved in pituitary tumor invasiveness.
Zhu D, Xiao Z, Wang Z, Hu B, Duan C, Zhu Z, Gao N, Zhu Y, Wang H
Journal of neurosurgery 2021 Feb 1;134(2):499-511
Journal of neurosurgery 2021 Feb 1;134(2):499-511
Red ginseng has stronger anti-aging effects compared to ginseng possibly due to its regulation of oxidative stress and the gut microbiota.
Peng X, Hao M, Zhao Y, Cai Y, Chen X, Chen H, Zhang Y, Dong L, Liu X, Ding C, Liu W, Yang M, Luo Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Dec;93:153772
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Dec;93:153772
Myrtenol improves brain damage and promotes angiogenesis in rats with cerebral infarction by activating the ERK1/2 signalling pathway.
Huang S, Tan Z, Cai J, Wang Z, Tian Y
Pharmaceutical biology 2021 Dec;59(1):584-593
Pharmaceutical biology 2021 Dec;59(1):584-593
Alisol A 24-acetate protects oxygen-glucose deprivation-induced brain microvascular endothelial cells against apoptosis through miR-92a-3p inhibition by targeting the B-cell lymphoma-2 gene.
Zhou Y, Wei W, Shen J, Lu L, Lu T, Wang H, Xue X
Pharmaceutical biology 2021 Dec;59(1):513-524
Pharmaceutical biology 2021 Dec;59(1):513-524
Kaempferol-induced GPER upregulation attenuates atherosclerosis via the PI3K/AKT/Nrf2 pathway.
Feng Z, Wang C, Yue, Jin, Meng Q, Wu J, Sun H
Pharmaceutical biology 2021 Dec;59(1):1106-1116
Pharmaceutical biology 2021 Dec;59(1):1106-1116
Azathioprine pretreatment ameliorates myocardial ischaemia reperfusion injury in diabetic rats by reducing oxidative stress, apoptosis, and inflammation.
Lu C, Liu L, Chen S, Niu J, Li S, Xie W, Cheng X
Clinical and experimental pharmacology & physiology 2021 Dec;48(12):1621-1632
Clinical and experimental pharmacology & physiology 2021 Dec;48(12):1621-1632
Ropivacaine Induces Cell Cycle Arrest in the G0/G1 Phase and Apoptosis of PC12 Cells via Inhibiting Mitochondrial STAT3 Translocation.
Zeng L, Li A, Zhang Z, Zhang F, Chen H, Wang Y, Ding X, Luo H
Inflammation 2021 Dec;44(6):2362-2376
Inflammation 2021 Dec;44(6):2362-2376
Lobetyolin inhibits the proliferation of breast cancer cells via ASCT2 down-regulation-induced apoptosis.
Chen Y, Tian Y, Jin G, Cui Z, Guo W, Zhang X, Liu X
Human & experimental toxicology 2021 Dec;40(12):2074-2086
Human & experimental toxicology 2021 Dec;40(12):2074-2086
AK003290 Protects Myocardial Cells Against Apoptosis and Promotes Cardiac Function Recovery Via miR-539-3p/ErbB4 Axis in Ischemic-Reperfusion Injury.
Tang Y, Tang Y, Xiang Y, Yan J, Guo K
DNA and cell biology 2021 Dec;40(12):1528-1538
DNA and cell biology 2021 Dec;40(12):1528-1538
Synergistic inhibitory effect of Smo inhibitor jervine and its combination with decitabine can target Hedgehog signaling pathway to inhibit myelodysplastic syndrome cell line.
Zhao F, Wang J, Yao L, Qin YT, Tuerxun N, Wang H, Jiang M, Hao JP
Hematology (Amsterdam, Netherlands) 2021 Dec;26(1):518-528
Hematology (Amsterdam, Netherlands) 2021 Dec;26(1):518-528
Exosomal ANXA2 derived from ovarian cancer cells regulates epithelial-mesenchymal plasticity of human peritoneal mesothelial cells.
Gao L, Nie X, Gou R, Hu Y, Dong H, Li X, Lin B
Journal of cellular and molecular medicine 2021 Dec;25(23):10916-10929
Journal of cellular and molecular medicine 2021 Dec;25(23):10916-10929
Danshensu derivative ADTM ameliorates CCl(4)‑induced acute liver injury in mice through inhibiting oxidative stress and apoptosis.
Jia S, Chen Q, Wu J, Yao X, Shao J, Cheng X, Zhang C, Cen D, Wang Y, Shen Z, Shan L, Yao X
Pathology, research and practice 2021 Dec;228:153656
Pathology, research and practice 2021 Dec;228:153656
PPP2R2A affects embryonic implantation by regulating the proliferation and apoptosis of Hu sheep endometrial stromal cells.
Li X, Yao X, Xie H, Zhang G, Deng M, Deng K, Gao X, Bao Y, Li K, Wang F
Theriogenology 2021 Dec;176:149-162
Theriogenology 2021 Dec;176:149-162
The endocytic pathway of Pt nanoclusters and their induced apoptosis of A549 and A549/Cis cells through c-Myc/p53 and Bcl-2/caspase-3 signaling pathways.
Zhao L, Li H, Huang X, Liu T, Xin Y, Xiao Z, Zhao W, Miao S, Chen J, Li Z, Mi Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Dec;144:112360
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Dec;144:112360
The XBP1‒MARCH5‒MFN2 Axis Confers Endoplasmic Reticulum Stress Resistance by Coordinating Mitochondrial Fission and Mitophagy in Melanoma.
Wang H, Yi X, Guo S, Wang S, Ma J, Zhao T, Shi Q, Tian Y, Wang H, Jia L, Gao T, Li C, Guo W
The Journal of investigative dermatology 2021 Dec;141(12):2932-2943.e12
The Journal of investigative dermatology 2021 Dec;141(12):2932-2943.e12
Activation of NLR family, domain of pyrin containing 3 inflammasome by nitrous oxide through thioredoxin-interacting protein to induce nerve cell injury.
Liu W, Zhang G, Sun B, Wang S, Lu Y, Xie H
Bioengineered 2021 Dec;12(1):4768-4779
Bioengineered 2021 Dec;12(1):4768-4779
Veratric acid alleviates liver ischemia/reperfusion injury by activating the Nrf2 signaling pathway.
Yu Q, Chen S, Tang H, Zhang X, Tao R, Yan Z, Shi J, Guo W, Zhang S
International immunopharmacology 2021 Dec;101(Pt B):108294
International immunopharmacology 2021 Dec;101(Pt B):108294
MiR-155-5p suppresses SOX1 to promote proliferation of cholangiocarcinoma via RAF/MEK/ERK pathway.
Wang D, Xiong F, Wu G, Liu W, Wang B, Chen Y
Cancer cell international 2021 Dec 7;21(1):656
Cancer cell international 2021 Dec 7;21(1):656
Long non-coding RNA CRNDE exacerbates NPC advancement mediated by the miR-545-5p/CCND2 axis.
Ge S, Jiang C, Li M, Cheng Z, Feng X
Cancer cell international 2021 Dec 4;21(1):650
Cancer cell international 2021 Dec 4;21(1):650
Inhibition of microRNA-30a alleviates vascular remodeling in pulmonary arterial hypertension.
Ma W, Qiu Z, Bai Z, Dai Y, Li C, Chen X, Song X, Shi D, Zhou Y, Pan Y, Liao Y, Liao M, Zhou Z
Molecular therapy. Nucleic acids 2021 Dec 3;26:678-693
Molecular therapy. Nucleic acids 2021 Dec 3;26:678-693
CircSTK40 contributes to recurrent implantation failure via modulating the HSP90/AKT/FOXO1 axis.
Ni T, Zhang Q, Li Y, Huang C, Zhou T, Yan J, Chen ZJ
Molecular therapy. Nucleic acids 2021 Dec 3;26:208-221
Molecular therapy. Nucleic acids 2021 Dec 3;26:208-221
CLEC12B suppresses lung cancer progression by inducing SHP-1 expression and inactivating the PI3K/AKT signaling pathway.
Chi D, Wang D, Zhang M, Ma H, Chen F, Sun Y
Experimental cell research 2021 Dec 15;409(2):112914
Experimental cell research 2021 Dec 15;409(2):112914
Miro1 provides neuroprotection via the mitochondrial trafficking pathway in a rat model of traumatic brain injury.
Chen C, Lu L, Zhu J, Gu X, Liu B, Li D, Chen G
Brain research 2021 Dec 15;1773:147685
Brain research 2021 Dec 15;1773:147685
Recombinant protein Schistosoma japonicum-derived molecule attenuates dextran sulfate sodium-induced colitis by inhibiting miRNA-217-5p to alleviate apoptosis.
Zhang LC, Wu XY, Yang RB, Chen F, Liu JH, Hu YY, Wu ZD, Wang LF, Sun X
World journal of gastroenterology 2021 Dec 14;27(46):7982-7994
World journal of gastroenterology 2021 Dec 14;27(46):7982-7994
Adipose-derived stem cells (ADSCs) inhibit the expression of anti-apoptosis proteins through up-regulation of ATF4 on breast cancer cells.
Ren J, Kong W, Lu F, Li Y
Annals of translational medicine 2021 Aug;9(16):1300
Annals of translational medicine 2021 Aug;9(16):1300
The miR-223-3p/MAP1B axis aggravates TGF-β-induced proliferation and migration of BPH-1 cells.
Wang Z, Zhang Y, Zhao C, Li Y, Hu X, Wu L, Chen M, Tong S
Cellular signalling 2021 Aug;84:110004
Cellular signalling 2021 Aug;84:110004
Genomic gain of RRS1 promotes hepatocellular carcinoma through reducing the RPL11-MDM2-p53 signaling.
Cao P, Yang A, Li P, Xia X, Han Y, Zhou G, Wang R, Yang F, Li Y, Zhang Y, Cui Y, Ji H, Lu L, He F, Zhou G
Science advances 2021 Aug;7(35)
Science advances 2021 Aug;7(35)
Diosgenin Protects Against Kidney Injury and Mitochondrial Apoptosis Induced by 3-MCPD Through the Regulation of ER Stress, Ca(2+) Homeostasis, and Bcl2 Expression.
Zhong Y, Jin C, Han J, Zhu J, Liu Q, Sun D, Xia X, Zhang Y, Peng X
Molecular nutrition & food research 2021 Aug;65(15):e2001202
Molecular nutrition & food research 2021 Aug;65(15):e2001202
6-Shogaol from ginger shows anti-tumor effect in cervical carcinoma via PI3K/Akt/mTOR pathway.
Pei XD, He ZL, Yao HL, Xiao JS, Li L, Gu JZ, Shi PZ, Wang JH, Jiang LH
European journal of nutrition 2021 Aug;60(5):2781-2793
European journal of nutrition 2021 Aug;60(5):2781-2793
Vitamin E regulates bovine granulosa cell apoptosis via NRF2-mediated defence mechanism by activating PI3K/AKT and ERK1/2 signalling pathways.
Wang M, Li Y, Gao Y, Li Q, Cao Y, Shen Y, Chen P, Yan J, Li J
Reproduction in domestic animals = Zuchthygiene 2021 Aug;56(8):1066-1084
Reproduction in domestic animals = Zuchthygiene 2021 Aug;56(8):1066-1084
Chicoric acid attenuates hyperglycemia-induced endothelial dysfunction through AMPK-dependent inhibition of oxidative/nitrative stresses.
Ma X, Zhang J, Wu Z, Wang X
Journal of receptor and signal transduction research 2021 Aug;41(4):378-392
Journal of receptor and signal transduction research 2021 Aug;41(4):378-392
W436, a novel SMART derivative, exhibits anti-hepatocarcinoma activity by inducing apoptosis and G2/M cell cycle arrest in vitro and in vivo and induces protective autophagy.
Man S, Wu Z, Sun R, Guan Q, Li Z, Zuo D, Zhang W, Wu Y
Journal of biochemical and molecular toxicology 2021 Aug;35(8):e22831
Journal of biochemical and molecular toxicology 2021 Aug;35(8):e22831
Tanshinone IIA alleviates acute ethanol-induced myocardial apoptosis mainly through inhibiting the expression of PDCD4 and activating the PI3K/Akt pathway.
Deng H, Yu B, Li Y
Phytotherapy research : PTR 2021 Aug;35(8):4309-4323
Phytotherapy research : PTR 2021 Aug;35(8):4309-4323
EGCG synergizes the therapeutic effect of irinotecan through enhanced DNA damage in human colorectal cancer cells.
Wu W, Dong J, Gou H, Geng R, Yang X, Chen D, Xiang B, Zhang Z, Ren S, Chen L, Liu J
Journal of cellular and molecular medicine 2021 Aug;25(16):7913-7921
Journal of cellular and molecular medicine 2021 Aug;25(16):7913-7921
Ring finger protein 19A is overexpressed in non-small cell lung cancer and mediates p53 ubiquitin-degradation to promote cancer growth.
Cheng Y, Hu Y, Wang H, Zhao Z, Jiang X, Zhang Y, Zhang J, Tong Y, Qiu X
Journal of cellular and molecular medicine 2021 Aug;25(16):7796-7808
Journal of cellular and molecular medicine 2021 Aug;25(16):7796-7808
TNF-α induces up-regulation of MicroRNA-27a via the P38 signalling pathway, which inhibits intervertebral disc degeneration by targeting FSTL1.
Shi J, Wang S, He Q, Liu K, Zhao W, Xie Q, Cheng L
Journal of cellular and molecular medicine 2021 Aug;25(15):7146-7156
Journal of cellular and molecular medicine 2021 Aug;25(15):7146-7156
Prenatal exposure to di-n-butyl phthalate induces erectile dysfunction in male adult rats.
Zhou X, Zhang T, Song L, Wang Y, Zhang Q, Cong R, Ji C, Luan J, Yao L, Zhang W, Song N, Wang S
Ecotoxicology and environmental safety 2021 Aug;219:112323
Ecotoxicology and environmental safety 2021 Aug;219:112323
Orexin A improves the cognitive impairment induced by chronic intermittent hypoxia in mice.
Zhu J, Tang S, Zhao D, Zeng Z, Mo H, Hu K
Brain research bulletin 2021 Aug;173:203-210
Brain research bulletin 2021 Aug;173:203-210
Vitamin E and selenium supplementation synergistically alleviate the injury induced by hydrogen peroxide in bovine granulosa cells.
Wang M, Li Y, Molenaar A, Li Q, Cao Y, Shen Y, Chen P, Yan J, Gao Y, Li J
Theriogenology 2021 Aug;170:91-106
Theriogenology 2021 Aug;170:91-106
SETD4 in the Proliferation, Migration, Angiogenesis, Myogenic Differentiation and Genomic Methylation of Bone Marrow Mesenchymal Stem Cells.
Liao X, Wu C, Shao Z, Zhang S, Zou Y, Wang K, Ha Y, Xing J, Zheng A, Shen Z, Zheng S, Guo J, Jie W
Stem cell reviews and reports 2021 Aug;17(4):1374-1389
Stem cell reviews and reports 2021 Aug;17(4):1374-1389
Ferroptosis inducer erastin sensitizes NSCLC cells to celastrol through activation of the ROS-mitochondrial fission-mitophagy axis.
Liu M, Fan Y, Li D, Han B, Meng Y, Chen F, Liu T, Song Z, Han Y, Huang L, Chang Y, Cao P, Nakai A, Tan K
Molecular oncology 2021 Aug;15(8):2084-2105
Molecular oncology 2021 Aug;15(8):2084-2105
Momordin Ic induces G0/1 phase arrest and apoptosis in colon cancer cells by suppressing SENP1/c-MYC signaling pathway.
Xianjun F, Xirui X, Jie T, Huiwen M, Shaojun Z, Qiaoyun L, Yunxin L, Xuqun S
Journal of pharmacological sciences 2021 Aug;146(4):249-258
Journal of pharmacological sciences 2021 Aug;146(4):249-258
CSNK2A1-mediated phosphorylation of HMGA2 modulates cisplatin resistance in cervical cancer.
Shi Z, Wu D, Xu H, Yang J, Sun X
FEBS open bio 2021 Aug;11(8):2245-2255
FEBS open bio 2021 Aug;11(8):2245-2255
Renoprotective effects of levosimendan on acute kidney injury following cardiac arrest via anti-inflammation, anti-apoptosis, and ERK activation.
Tian L, Wang S, Zhao L, Lu X, Zhu C, Gong H, Yang W
FEBS open bio 2021 Aug;11(8):2236-2244
FEBS open bio 2021 Aug;11(8):2236-2244
Cypermethrin induces Sertoli cell apoptosis through mitochondrial pathway associated with calcium.
Wang HX, Zhang R, Li Z, Wang LS, Yu Y, Wang Q, Ding Z, Zhang JP, Zhang MR, Xu LC
Toxicology research 2021 Aug;10(4):742-750
Toxicology research 2021 Aug;10(4):742-750
Cyanidin-3-glucoside suppresses the progression of lung adenocarcinoma by downregulating TP53I3 and inhibiting PI3K/AKT/mTOR pathway.
Chen X, Zhang W, Xu X
World journal of surgical oncology 2021 Aug 6;19(1):232
World journal of surgical oncology 2021 Aug 6;19(1):232
Enriched environment remedies cognitive dysfunctions and synaptic plasticity through NMDAR-Ca(2+)-Activin A circuit in chronic cerebral hypoperfusion rats.
Zhang X, Shi X, Wang J, Xu Z, He J
Aging 2021 Aug 30;13(16):20748-20761
Aging 2021 Aug 30;13(16):20748-20761
The screening of drug-induced nephrotoxicity using gold nanocluster-based ratiometric fluorescent probes.
Liu Q, Li J, Liu X, Yuan L, Zhao L, Chang YT, Liu X, Peng J
Nanoscale 2021 Aug 28;13(32):13835-13844
Nanoscale 2021 Aug 28;13(32):13835-13844
Apatinib triggers autophagic and apoptotic cell death via VEGFR2/STAT3/PD-L1 and ROS/Nrf2/p62 signaling in lung cancer.
Xie C, Zhou X, Liang C, Li X, Ge M, Chen Y, Yin J, Zhu J, Zhong C
Journal of experimental & clinical cancer research : CR 2021 Aug 24;40(1):266
Journal of experimental & clinical cancer research : CR 2021 Aug 24;40(1):266
PDGF-BB/SA/Dex injectable hydrogels accelerate BMSC-mediated functional full thickness skin wound repair by promoting angiogenesis.
Zhang Z, Li Z, Wang Y, Wang Q, Yao M, Zhao L, Shi J, Guan F, Ma S
Journal of materials chemistry. B 2021 Aug 21;9(31):6176-6189
Journal of materials chemistry. B 2021 Aug 21;9(31):6176-6189
Tubeimoside I protects against sepsis-induced cardiac dysfunction via SIRT3.
Cheng Z, Lv D, Luo M, Wang R, Guo Y, Yang X, Huang L, Li X, Li C, Shang FF, Huang B, Shen J, Luo S, Yan J
European journal of pharmacology 2021 Aug 15;905:174186
European journal of pharmacology 2021 Aug 15;905:174186
Identification of Potentially Related Genes and Mechanisms Involved in Skeletal Muscle Atrophy Induced by Excessive Exercise in Zebrafish.
Sun CC, Zhou ZQ, Chen ZL, Zhu RK, Yang D, Peng XY, Zheng L, Tang CF
Biology 2021 Aug 10;10(8)
Biology 2021 Aug 10;10(8)
Arsenic-induced autophagy regulates apoptosis in AML-12 cells.
Yuan M, Sun Z, Manthari RK, Zhao Y, Guo Q, Yang K, Wang J
Toxicology in vitro : an international journal published in association with BIBRA 2021 Apr;72:105074
Toxicology in vitro : an international journal published in association with BIBRA 2021 Apr;72:105074
Silencing MAP3K1 expression inhibits the proliferation of goat hair follicle stem cells.
Ma J, Wang J, Feng Y, Zhang L, Hu H, Wang Q, Chu C, Qu J, Wang Y, Li Y
In vitro cellular & developmental biology. Animal 2021 Apr;57(4):428-437
In vitro cellular & developmental biology. Animal 2021 Apr;57(4):428-437
Resveratrol-induced apoptosis is associated with regulating the miR-492/CD147 pathway in malignant melanoma cells.
Zhao S, Tang L, Chen W, Su J, Li F, Chen X, Wu L
Naunyn-Schmiedeberg's archives of pharmacology 2021 Apr;394(4):797-807
Naunyn-Schmiedeberg's archives of pharmacology 2021 Apr;394(4):797-807
Expression of long-chain noncoding RNA GAS5 in osteoarthritis and its effect on apoptosis and autophagy of osteoarthritis chondrocytes.
Ji Q, Qiao X, Liu Y, Wang D
Histology and histopathology 2021 Apr;36(4):475-484
Histology and histopathology 2021 Apr;36(4):475-484
CRSP8 promotes thyroid cancer progression by antagonizing IKKα-induced cell differentiation.
Liao Y, Hua Y, Li Y, Zhang C, Yu W, Guo P, Zou K, Li W, Sun Y, Wang R, Zuo Y, Sui S, Tian C, Hao J, Chen M, Hu S, Chen M, Long Q, Wang X, Zou L, Xie F, Guo W, Deng W
Cell death and differentiation 2021 Apr;28(4):1347-1363
Cell death and differentiation 2021 Apr;28(4):1347-1363
Fusobacterium nucleatum Promotes Cisplatin-Resistance and Migration of Oral Squamous Carcinoma Cells by Up-Regulating Wnt5a-Mediated NFATc3 Expression.
Da J, Wang X, Li L, Xu Y
The Tohoku journal of experimental medicine 2021 Apr;253(4):249-259
The Tohoku journal of experimental medicine 2021 Apr;253(4):249-259
Elevated Secretion of Aldosterone Increases TG/HDL-C Ratio and Potentiates The Ox-LDL-Induced Dysfunction of HUVEC.
Zhang Q, Pan Y, Ma X, Yang H, Chang J, Hong L, Yan H, Zhang SH
Cell journal 2021 Apr;23(1):61-69
Cell journal 2021 Apr;23(1):61-69
MicroRNA-1 affects the development of the neural crest and craniofacial skeleton via the mitochondrial apoptosis pathway.
Zhao N, Qin W, Wang D, Raquel AG, Yuan L, Mao Y, Ma C, Xiao Z, Ma J
Experimental and therapeutic medicine 2021 Apr;21(4):379
Experimental and therapeutic medicine 2021 Apr;21(4):379
The miR-136-5p/ROCK1 axis suppresses invasion and migration, and enhances cisplatin sensitivity in head and neck cancer cells.
Yang B, Zang J, Yuan W, Jiang X, Zhang F
Experimental and therapeutic medicine 2021 Apr;21(4):317
Experimental and therapeutic medicine 2021 Apr;21(4):317
Dracomolphin A-E, new lignans from Dracocephalum moldavica.
Zhang H, Wang S, Liu Q, Zheng H, Liu X, Wang X, Shen T, Ren D
Fitoterapia 2021 Apr;150:104841
Fitoterapia 2021 Apr;150:104841
Anti-androgenetic alopecia effect of policosanol from Chinese wax by regulating abnormal hormone levels to suppress premature hair follicle entry into the regression phase.
Wang ZD, Feng Y, Sun L, Gan J, Li X, Ding WF, Chen XM
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Apr;136:111241
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Apr;136:111241
Change on apoptosis, autophagy and mitochondria of the Harderian gland in Cricetulus barabensis during age.
Kong XT, Wang Z, Mou JJ, Li CS, Xue HL, Wu M, Chen L, Xu JH, Xu LX
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2021 Apr-May;253:110547
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 2021 Apr-May;253:110547
Construction of Smart Nanotheranostic Platform Bi-Ag@PVP: Multimodal CT/PA Imaging-Guided PDT/PTT for Cancer Therapy.
Zhou Z, Xie J, Ma S, Luo X, Liu J, Wang S, Chen Y, Yan J, Luo F
ACS omega 2021 Apr 27;6(16):10723-10734
ACS omega 2021 Apr 27;6(16):10723-10734
Coibamide A kills cancer cells through inhibiting autophagy.
Shi W, Lu D, Wu C, Li M, Ding Z, Li Y, Chen B, Lin X, Su W, Shao X, Xia Z, Fang L, Liu K, Li H
Biochemical and biophysical research communications 2021 Apr 2;547:52-58
Biochemical and biophysical research communications 2021 Apr 2;547:52-58
Inhibition of Notch1 signaling reduces hepatocyte injury in nonalcoholic fatty liver disease via autophagy.
Zhang M, Wu P, Li M, Guo Y, Tian T, Liao X, Tan S
Biochemical and biophysical research communications 2021 Apr 2;547:131-138
Biochemical and biophysical research communications 2021 Apr 2;547:131-138
Reduction of Autophagosome Overload Attenuates Neuronal Cell Death After Traumatic Brain Injury.
Quan X, Song L, Zheng X, Liu S, Ding H, Li S, Xu G, Li X, Liu L
Neuroscience 2021 Apr 15;460:107-119
Neuroscience 2021 Apr 15;460:107-119
Tissue-based metabolomics reveals metabolic biomarkers and potential therapeutic targets for esophageal squamous cell carcinoma.
Chen Z, Gao Y, Huang X, Yao Y, Chen K, Zeng S, Mao W
Journal of pharmaceutical and biomedical analysis 2021 Apr 15;197:113937
Journal of pharmaceutical and biomedical analysis 2021 Apr 15;197:113937
Kaempferol induces ROS-dependent apoptosis in pancreatic cancer cells via TGM2-mediated Akt/mTOR signaling.
Wang F, Wang L, Qu C, Chen L, Geng Y, Cheng C, Yu S, Wang D, Yang L, Meng Z, Chen Z
BMC cancer 2021 Apr 12;21(1):396
BMC cancer 2021 Apr 12;21(1):396
Drug-Loaded, Polyurethane Coated Nitinol Stents for the Controlled Release of Docetaxel for the Treatment of Oesophageal Cancer.
Fouladian P, Jin Q, Arafat M, Song Y, Guo X, Blencowe A, Garg S
Pharmaceuticals (Basel, Switzerland) 2021 Apr 1;14(4)
Pharmaceuticals (Basel, Switzerland) 2021 Apr 1;14(4)
Silencing lncRNA TUG1 Alleviates LPS-Induced Mouse Hepatocyte Inflammation by Targeting miR-140/TNF.
Liu QM, Liu LL, Li XD, Tian P, Xu H, Li ZL, Wang LK
Frontiers in cell and developmental biology 2020;8:616416
Frontiers in cell and developmental biology 2020;8:616416
NDUFA4L2 Regulated by HIF-1α Promotes Metastasis and Epithelial-Mesenchymal Transition of Osteosarcoma Cells Through Inhibiting ROS Production.
Xu WN, Yang RZ, Zheng HL, Jiang LS, Jiang SD
Frontiers in cell and developmental biology 2020;8:515051
Frontiers in cell and developmental biology 2020;8:515051
miR-205 Expression Elevated With EDS Treatment and Induced Leydig Cell Apoptosis by Targeting RAP2B via the PI3K/AKT Signaling Pathway.
Cui Y, Chen R, Ma L, Yang W, Chen M, Zhang Y, Yu S, Dong W, Zeng W, Lan X, Pan C
Frontiers in cell and developmental biology 2020;8:448
Frontiers in cell and developmental biology 2020;8:448
miR-124-3p Suppresses the Invasiveness and Metastasis of Hepatocarcinoma Cells via Targeting CRKL.
Majid A, Wang J, Nawaz M, Abdul S, Ayesha M, Guo C, Liu Q, Liu S, Sun MZ
Frontiers in molecular biosciences 2020;7:223
Frontiers in molecular biosciences 2020;7:223
The Novel Synthetic Triterpene Methyl 3β-O-[4-(2-Aminoethylamino)-4-oxo-butyryl]olean-12-ene-28-oate Inhibits Breast Tumor Cell Growth in Vitro and in Vivo.
Feng B, Zhao C, Li J, Yu J, Zhang Y, Zhang X, Tian T, Zhao L
Chemical & pharmaceutical bulletin 2020;68(10):962-970
Chemical & pharmaceutical bulletin 2020;68(10):962-970
RGS12 is required for the maintenance of mitochondrial function during skeletal development.
Yuan G, Yang S, Liu M, Yang S
Cell discovery 2020;6:59
Cell discovery 2020;6:59
Anti-inflammation and anti-apoptosis effects of growth arrest-specific protein 6 in acute liver injury induced by LPS/D-GalN in mice.
Wang Q, Zhao Y, Zang B
Acta cirurgica brasileira 2020;35(2):e202000204
Acta cirurgica brasileira 2020;35(2):e202000204
Effect of Wenshen-Yanggan Decoction on Movement Disorder and Substantia Nigra Dopaminergic Neurons in Mice with Chronic Parkinson's Disease.
Tang L, Chen C, Xia B, Wu W, Wei R, Zhu G, Tang J, Zhou X, Liang Y, Zhang ZN, Lu Y, Yang Y, Zhao Y
Evidence-based complementary and alternative medicine : eCAM 2020;2020:9838295
Evidence-based complementary and alternative medicine : eCAM 2020;2020:9838295
Exosomes from Bone Marrow Microenvironment-Derived Mesenchymal Stem Cells Affect CML Cells Growth and Promote Drug Resistance to Tyrosine Kinase Inhibitors.
Zhang X, Yang Y, Yang Y, Chen H, Tu H, Li J
Stem cells international 2020;2020:8890201
Stem cells international 2020;2020:8890201
Methane-Rich Saline Alleviates CA/CPR Brain Injury by Inhibiting Oxidative Stress, Microglial Activation-Induced Inflammatory Responses, and ER Stress-Mediated Apoptosis.
Cui R, Liu S, Wang C, Liu T, Ren J, Jia Y, Tong Y, Liu C, Zhang J
Oxidative medicine and cellular longevity 2020;2020:8829328
Oxidative medicine and cellular longevity 2020;2020:8829328
Network Pharmacology-Based Strategy Reveals the Effects of Hedysarum multijugum Maxim.-Radix Salviae Compound on Oxidative Capacity and Cardiomyocyte Apoptosis in Rats with Diabetic Cardiomyopathy.
Zhang S, Yuan Z, Wu H, Li W, Li L, Huang H
BioMed research international 2020;2020:8260703
BioMed research international 2020;2020:8260703
Neuroprotective Effect of the Inhibitor Salubrinal after Cardiac Arrest in a Rodent Model.
Zhang J, Wang Y, Ju M, Song J, Zheng Y, Lin S, Zhu D, Wen L, Zhong M, Pan S, Yang G
Oxidative medicine and cellular longevity 2020;2020:7468738
Oxidative medicine and cellular longevity 2020;2020:7468738
Combination of Dichloroacetate and Atorvastatin Regulates Excessive Proliferation and Oxidative Stress in Pulmonary Arterial Hypertension Development via p38 Signaling.
Li T, Li S, Feng Y, Zeng X, Dong S, Li J, Zha L, Luo H, Zhao L, Liu B, Ou Z, Lin W, Zhang M, Li S, Jiang Q, Qi Q, Xu Q, Yu Z
Oxidative medicine and cellular longevity 2020;2020:6973636
Oxidative medicine and cellular longevity 2020;2020:6973636
Nei Endonuclease VIII-Like1 (NEIL1) Inhibits Apoptosis of Human Colorectal Cancer Cells.
Xue W, Liu Y, Xin N, Miao J, Du J, Wang Y, Shi H, Wei Y, Zhang H, Chen Y, Gao Y, Li D, Feng Y, Yan J, Zhang J, Hou N, Huang C, Han J
BioMed research international 2020;2020:5053975
BioMed research international 2020;2020:5053975
The Nrf2/PGC1α Pathway Regulates Antioxidant and Proteasomal Activity to Alter Cisplatin Sensitivity in Ovarian Cancer.
Deng X, Lin N, Fu J, Xu L, Luo H, Jin Y, Liu Y, Sun L, Su J
Oxidative medicine and cellular longevity 2020;2020:4830418
Oxidative medicine and cellular longevity 2020;2020:4830418
Protective Effects of Cinnamaldehyde against Mesenteric Ischemia-Reperfusion-Induced Lung and Liver Injuries in Rats.
Almoiliqy M, Wen J, Qaed E, Sun Y, Lian M, Mousa H, Al-Azab M, Zaky MY, Chen D, Wang L, Al-Sharabi A, Liu Z, Sun P, Lin Y
Oxidative medicine and cellular longevity 2020;2020:4196548
Oxidative medicine and cellular longevity 2020;2020:4196548
Overexpression of BMPER in Ovarian Cancer and the Mechanism by which It Promotes Malignant Biological Behavior in Tumor Cells.
Xi Y, Nie X, Wang J, Gao L, Lin B
BioMed research international 2020;2020:3607436
BioMed research international 2020;2020:3607436
miR193b Promotes Apoptosis of Gastric Cancer Cells via Directly Mediating the Akt Pathway.
Tian R, Jiang H, Shao L, Yu Y, Guo Q, Cao B, Guo S
BioMed research international 2020;2020:2863236
BioMed research international 2020;2020:2863236
Inhibition of Specificity Protein 1 Is Involved in Phloretin-Induced Suppression of Prostate Cancer.
Kang D, Zuo W, Wu Q, Zhu Q, Liu P
BioMed research international 2020;2020:1358674
BioMed research international 2020;2020:1358674
Silencing of PRDX2 Inhibits the Proliferation and Invasion of Non-Small Cell Lung Cancer Cells.
Jing X, Du L, Niu A, Wang Y, Wang Y, Wang C
BioMed research international 2020;2020:1276328
BioMed research international 2020;2020:1276328
Alantolactone inhibits cell autophagy and promotes apoptosis via AP2M1 in acute lymphoblastic leukemia.
Shi C, Lan W, Wang Z, Yang D, Wei J, Liu Z, Teng Y, Gu M, Yuan T, Cao F, Zhou J, Li Y
Cancer cell international 2020;20:442
Cancer cell international 2020;20:442
A novel chalcone derivative has antitumor activity in melanoma by inducing DNA damage through the upregulation of ROS products.
Li K, Zhao S, Long J, Su J, Wu L, Tao J, Zhou J, Zhang J, Chen X, Peng C
Cancer cell international 2020;20:36
Cancer cell international 2020;20:36
A novel chalcone derivative suppresses melanoma cell growth through targeting Fyn/Stat3 pathway.
Tang L, Long J, Li K, Zhang X, Chen X, Peng C
Cancer cell international 2020;20:256
Cancer cell international 2020;20:256
miR-454 suppresses the proliferation and invasion of ovarian cancer by targeting E2F6.
An Y, Zhang J, Cheng X, Li B, Tian Y, Zhang X, Zhao F
Cancer cell international 2020;20:237
Cancer cell international 2020;20:237
Silencing of miR-17-5p suppresses cell proliferation and promotes cell apoptosis by directly targeting PIK3R1 in laryngeal squamous cell carcinoma.
Wang JX, Jia XJ, Liu Y, Dong JH, Ren XM, Xu O, Liu SH, Shan CG
Cancer cell international 2020;20:14
Cancer cell international 2020;20:14
Long non-coding RNA LINC01503 promotes the progression of hepatocellular carcinoma via activating MAPK/ERK pathway.
Wang MR, Fang D, Di MP, Guan JL, Wang G, Liu L, Sheng JQ, Tian DA, Li PY
International journal of medical sciences 2020;17(9):1224-1234
International journal of medical sciences 2020;17(9):1224-1234
Downregulation of Cypher induces apoptosis in cardiomyocytes via Akt/p38 MAPK signaling pathway.
Xuan T, Wang D, Lv J, Pan Z, Fang J, Xiang Y, Cheng H, Wang X, Guo X
International journal of medical sciences 2020;17(15):2328-2337
International journal of medical sciences 2020;17(15):2328-2337
Drp1-mediated mitochondrial fission contributes to baicalein-induced apoptosis and autophagy in lung cancer via activation of AMPK signaling pathway.
Deng X, Liu J, Liu L, Sun X, Huang J, Dong J
International journal of biological sciences 2020;16(8):1403-1416
International journal of biological sciences 2020;16(8):1403-1416
Mitochondrial KATP channels contribute to the protective effects of hydrogen sulfide against impairment of central chemoreception of rat offspring exposed to maternal cigarette smoke.
Lei F, Wang W, Fu Y, Wang J, Zheng Y
PloS one 2020;15(10):e0237643
PloS one 2020;15(10):e0237643
Shikonin and 4-hydroxytamoxifen synergistically inhibit the proliferation of breast cancer cells through activating apoptosis signaling pathway in vitro and in vivo.
Lin HY, Han HW, Wang YS, He DL, Sun WX, Feng L, Wen ZL, Yang MK, Lu GH, Wang XM, Qi JL, Yang YH
Chinese medicine 2020;15:23
Chinese medicine 2020;15:23
RNA Binding Protein Motif 3 Inhibits Oxygen-Glucose Deprivation/Reoxygenation-Induced Apoptosis Through Promoting Stress Granules Formation in PC12 Cells and Rat Primary Cortical Neurons.
Si W, Li Z, Huang Z, Ye S, Li X, Li Y, Kuang W, Chen D, Zhu M
Frontiers in cellular neuroscience 2020;14:559384
Frontiers in cellular neuroscience 2020;14:559384
Induction of Autophagy by Baicalin Through the AMPK-mTOR Pathway Protects Human Skin Fibroblasts from Ultraviolet B Radiation-Induced Apoptosis.
Zhang JA, Luan C, Huang D, Ju M, Chen K, Gu H
Drug design, development and therapy 2020;14:417-428
Drug design, development and therapy 2020;14:417-428
Thymol Isolated from Thymus vulgaris L. Inhibits Colorectal Cancer Cell Growth and Metastasis by Suppressing the Wnt/β-Catenin Pathway.
Zeng Q, Che Y, Zhang Y, Chen M, Guo Q, Zhang W
Drug design, development and therapy 2020;14:2535-2547
Drug design, development and therapy 2020;14:2535-2547
The knockdown of the sepiapterin reductase gene suppresses the proliferation of breast cancer by inducing ROS-mediated apoptosis.
Zhang X, Chen Y, Wang K, Tang J, Chen Y, Jin G, Liu X
International journal of clinical and experimental pathology 2020;13(9):2228-2239
International journal of clinical and experimental pathology 2020;13(9):2228-2239
Huaier Restrains Cholangiocarcinoma Progression in vitro and in vivo Through Modulating lncRNA TP73-AS1 and Inducing Oxidative Stress.
Ji D, Zheng W, Huang P, Yao Y, Zhong X, Kang P, Wang Z, Shi G, Xu Y, Cui Y
OncoTargets and therapy 2020;13:7819-7837
OncoTargets and therapy 2020;13:7819-7837
Derlin-1 Promotes the Progression of Human Hepatocellular Carcinoma via the Activation of AKT Pathway.
Fan J, Tian L, Huang S, Zhang J, Zhao B
OncoTargets and therapy 2020;13:5407-5417
OncoTargets and therapy 2020;13:5407-5417
Connexin 43 Modulates the Cellular Resistance to Paclitaxel via Targeting β-Tubulin in Triple-Negative Breast Cancer.
Fu Y, Sun X, Gu Z, Zhuang Z
OncoTargets and therapy 2020;13:5323-5335
OncoTargets and therapy 2020;13:5323-5335
β-Elemene Enhances the Chemotherapeutic Effect of 5-Fluorouracil in Triple-Negative Breast Cancer via PI3K/AKT, RAF-MEK-ErK, and NF-κB Signaling Pathways.
Su P, Ahmad B, Zou K, Zou L
OncoTargets and therapy 2020;13:5207-5222
OncoTargets and therapy 2020;13:5207-5222
LncRNA MIR503HG Promotes High-Glucose-Induced Proximal Tubular Cell Apoptosis by Targeting miR-503-5p/Bcl-2 Pathway.
Cao X, Fan QL
Diabetes, metabolic syndrome and obesity : targets and therapy 2020;13:4507-4517
Diabetes, metabolic syndrome and obesity : targets and therapy 2020;13:4507-4517
Brevilin A Inhibits STAT3 Signaling and Induces ROS-Dependent Apoptosis, Mitochondrial Stress and Endoplasmic Reticulum Stress in MCF-7 Breast Cancer Cells.
Saleem MZ, Nisar MA, Alshwmi M, Din SRU, Gamallat Y, Khan M, Ma T
OncoTargets and therapy 2020;13:435-450
OncoTargets and therapy 2020;13:435-450
Overexpression of TEM8 promotes ovarian cancer progression via Rac1/Cdc42/JNK and MEK/ERK/STAT3 signaling pathways.
Wang CX, Xiong HF, Wang S, Wang J, Nie X, Guo Q, Li X, Qi Y, Liu JJ, Lin B
American journal of translational research 2020;12(7):3557-3576
American journal of translational research 2020;12(7):3557-3576
Fenofibrate-induced mitochondrial dysfunction and metabolic reprogramming reversal: the anti-tumor effects in gastric carcinoma cells mediated by the PPAR pathway.
Chen L, Peng J, Wang Y, Jiang H, Wang W, Dai J, Tang M, Wei Y, Kuang H, Xu G, Xu H, Zhou F
American journal of translational research 2020;12(2):428-446
American journal of translational research 2020;12(2):428-446
Selaginellin B induces apoptosis and autophagy in pancreatic cancer cells via the JAK2/STAT3 signaling pathway.
Chu P, Wang S, Zhu X, Yang Y, Li H, Tesfaldet T, Shopit A, Yang Y, Ma X, Peng J, Tang Z, Sun Z
American journal of translational research 2020;12(11):7127-7143
American journal of translational research 2020;12(11):7127-7143
LongShengZhi Capsule Attenuates Alzheimer-Like Pathology in APP/PS1 Double Transgenic Mice by Reducing Neuronal Oxidative Stress and Inflammation.
Yin Z, Wang X, Zheng S, Cao P, Chen Y, Yu M, Liao C, Zhang Z, Han J, Duan Y, Yang X, Zhang S
Frontiers in aging neuroscience 2020;12:582455
Frontiers in aging neuroscience 2020;12:582455
Targeting PIK3CG in Combination with Paclitaxel as a Potential Therapeutic Regimen in Claudin-Low Breast Cancer.
Chang J, Hong L, Liu Y, Pan Y, Yang H, Ye W, Xu K, Li Z, Zhang S
Cancer management and research 2020;12:2641-2651
Cancer management and research 2020;12:2641-2651
Down-regulation of USP8 Inhibits Cholangiocarcinoma Cell Proliferation and Invasion.
Jing X, Chen Y, Chen Y, Shi G, Lv S, Cheng N, Feng C, Xin Z, Zhang L, Wu J
Cancer management and research 2020;12:2185-2194
Cancer management and research 2020;12:2185-2194
AOC1 Contributes to Tumor Progression by Promoting the AKT and EMT Pathways in Gastric Cancer.
Xu F, Xu Y, Xiong JH, Zhang JH, Wu J, Luo J, Xiong JP
Cancer management and research 2020;12:1789-1798
Cancer management and research 2020;12:1789-1798
Hyperin Controls the Development and Therapy of Gastric Cancer via Regulating Wnt/β-Catenin Signaling.
Ping MH
Cancer management and research 2020;12:11773-11782
Cancer management and research 2020;12:11773-11782
Baohuoside I via mTOR Apoptotic Signaling to Inhibit Glioma Cell Growth.
Guo Y, Wang C, Jiang M, Zhu H, Weng M, Sun L, Zhang Y
Cancer management and research 2020;12:11435-11444
Cancer management and research 2020;12:11435-11444
Inhibiting EMT, stemness and cell cycle involved in baicalin-induced growth inhibition and apoptosis in colorectal cancer cells.
Yang B, Bai H, Sa Y, Zhu P, Liu P
Journal of Cancer 2020;11(8):2303-2317
Journal of Cancer 2020;11(8):2303-2317
Mesenchymal stem/stromal cells-derived IL-6 promotes nasopharyngeal carcinoma growth and resistance to cisplatin via upregulating CD73 expression.
Zeng J, Chen S, Li C, Ye Z, Lin B, Liang Y, Wang B, Ma Y, Chai X, Zhang X, Zhou K, Zhang Q, Zhang H
Journal of Cancer 2020;11(8):2068-2079
Journal of Cancer 2020;11(8):2068-2079
Gambogic acid affects ESCC progression through regulation of PI3K/AKT/mTOR signal pathway.
Yu J, Wang W, Yao W, Yang Z, Gao P, Liu M, Wang H, Chen S, Wang D, Wang W, Sun G
Journal of Cancer 2020;11(19):5568-5577
Journal of Cancer 2020;11(19):5568-5577
Knockdown of the long noncoding RNA XIST suppresses glioma progression by upregulating miR-204-5p.
Shen J, Xiong J, Shao X, Cheng H, Fang X, Sun Y, Di G, Mao J, Jiang X
Journal of Cancer 2020;11(15):4550-4559
Journal of Cancer 2020;11(15):4550-4559
Total saponins from Lilium lancifolium: a promising alternative to inhibit the growth of gastric carcinoma cells.
Zhang YY, Luo LM, Wang YX, Zhu N, Zhao TJ, Qin L
Journal of Cancer 2020;11(14):4261-4273
Journal of Cancer 2020;11(14):4261-4273
Oleoylethanolamide Protects Against Acute Liver Injury by Regulating Nrf-2/HO-1 and NLRP3 Pathways in Mice.
Hu J, Zhu Z, Ying H, Yao J, Ma H, Li L, Zhao Y
Frontiers in pharmacology 2020;11:605065
Frontiers in pharmacology 2020;11:605065
Ursodeoxycholic Acid Protects Against Arsenic Induced Hepatotoxicity by the Nrf2 Signaling Pathway.
Li C, Zhang S, Li L, Hu Q, Ji S
Frontiers in pharmacology 2020;11:594496
Frontiers in pharmacology 2020;11:594496
A Mechanism of Action Study on Danggui Sini Decoction to Discover Its Therapeutic Effect on Gastric Cancer.
Pan B, Wang Y, Wu C, Jia J, Huang C, Fang S, Liu L
Frontiers in pharmacology 2020;11:592903
Frontiers in pharmacology 2020;11:592903
Acylated Ghrelin is Protective Against 6-OHDA-induced Neurotoxicity by Regulating Autophagic Flux.
He X, Yuan W, Liu F, Feng J, Guo Y
Frontiers in pharmacology 2020;11:586302
Frontiers in pharmacology 2020;11:586302
miR-222 Suppresses Immature Porcine Sertoli Cell Growth by Targeting the GRB10 Gene Through Inactivating the PI3K/AKT Signaling Pathway.
Luo H, Peng F, Weng B, Tang X, Chen Y, Yang A, Chen B, Ran M
Frontiers in genetics 2020;11:581593
Frontiers in genetics 2020;11:581593
miR-149-5p Regulates Goat Hair Follicle Stem Cell Proliferation and Apoptosis by Targeting the CMTM3/AR Axis During Superior-Quality Brush Hair Formation.
Wang J, Qu J, Li Y, Feng Y, Ma J, Zhang L, Chu C, Hu H, Wang Y, Ji D
Frontiers in genetics 2020;11:529757
Frontiers in genetics 2020;11:529757
An Integrative Pharmacology-Based Analysis of Refined Qingkailing Injection Against Cerebral Ischemic Stroke: A Novel Combination of Baicalin, Geniposide, Cholic Acid, and Hyodeoxycholic Acid.
Ma C, Wang X, Xu T, Zhang S, Liu S, Zhai C, Wang Z, Mu J, Li C, Cheng F, Wang Q
Frontiers in pharmacology 2020;11:519
Frontiers in pharmacology 2020;11:519
Sodium Butyrate Abrogates the Growth and Pathogenesis of Mycobacterium bovis via Regulation of Cathelicidin (LL37) Expression and NF-κB Signaling.
Zhang K, Hussain T, Wang J, Li M, Wang W, Ma X, Liao Y, Yao J, Song Y, Liang Z, Zhou X, Xu L
Frontiers in microbiology 2020;11:433
Frontiers in microbiology 2020;11:433
α-Cyperone Attenuates H(2)O(2)-Induced Oxidative Stress and Apoptosis in SH-SY5Y Cells via Activation of Nrf2.
Huang B, Liu J, Fu S, Zhang Y, Li Y, He D, Ran X, Yan X, Du J, Meng T, Gao X, Liu D
Frontiers in pharmacology 2020;11:281
Frontiers in pharmacology 2020;11:281
Tilianin Extracted From Dracocephalum moldavica L. Induces Intrinsic Apoptosis and Drives Inflammatory Microenvironment Response on Pharyngeal Squamous Carcinoma Cells via Regulating TLR4 Signaling Pathways.
Jiang H, Zeng L, Dong X, Guo S, Xing J, Li Z, Liu R
Frontiers in pharmacology 2020;11:205
Frontiers in pharmacology 2020;11:205
Purmorphamine Attenuates Neuro-Inflammation and Synaptic Impairments After Hypoxic-Ischemic Injury in Neonatal Mice via Shh Signaling.
Liu D, Bai X, Ma W, Xin D, Chu X, Yuan H, Qiu J, Ke H, Yin S, Chen W, Wang Z
Frontiers in pharmacology 2020;11:204
Frontiers in pharmacology 2020;11:204
Dose- and Time-Dependent Cytotoxicity of Carteolol in Corneal Endothelial Cells and the Underlying Mechanisms.
Su W, Zhao J, Fan TJ
Frontiers in pharmacology 2020;11:202
Frontiers in pharmacology 2020;11:202
AKT Inhibitor SC66 Inhibits Proliferation and Induces Apoptosis in Human Glioblastoma Through Down-Regulating AKT/β-Catenin Pathway.
Gao L, Liu J, Xu P, Deng G, Liu B, Yuan F, Tan Y, Sun Q, Xu Y, Zhang H, Qi Y, Han S, Yang K, Geng R, Jiang H, Chen Q
Frontiers in pharmacology 2020;11:1102
Frontiers in pharmacology 2020;11:1102
Inhibition of JNK-Mediated Autophagy Promotes Proscillaridin A- Induced Apoptosis via ROS Generation, Intracellular Ca(+2) Oscillation and Inhibiting STAT3 Signaling in Breast Cancer Cells.
Saleem MZ, Alshwmi M, Zhang H, Din SRU, Nisar MA, Khan M, Alam S, Alam G, Jin L, Ma T
Frontiers in pharmacology 2020;11:01055
Frontiers in pharmacology 2020;11:01055
Targeting BCL10 by small peptides for the treatment of B cell lymphoma.
Bao W, Sun C, Sun X, He M, Yu H, Yan W, Wen F, Zhang L, Yang C
Theranostics 2020;10(25):11622-11636
Theranostics 2020;10(25):11622-11636
3D printed intelligent scaffold prevents recurrence and distal metastasis of breast cancer.
Shi X, Cheng Y, Wang J, Chen H, Wang X, Li X, Tan W, Tan Z
Theranostics 2020;10(23):10652-10664
Theranostics 2020;10(23):10652-10664
Whole-Exome Sequencing Reveals New Potential Mutations Genes for Primary Mucosa-Associated Lymphoid Tissue Lymphoma Arising From the Kidney.
Wen S, Liu T, Zhang H, Zhou X, Jin H, Sun M, Yun Z, Luo H, Ni Z, Zhao R, Fan B
Frontiers in oncology 2020;10:609839
Frontiers in oncology 2020;10:609839
Disulfiram Chelated With Copper Inhibits the Growth of Gastric Cancer Cells by Modulating Stress Response and Wnt/β-catenin Signaling.
Wang L, Chai X, Wan R, Zhang H, Zhou C, Xiang L, Paul ME, Li Y
Frontiers in oncology 2020;10:595718
Frontiers in oncology 2020;10:595718
Fusobacterium nucleatum Promotes the Development of Ulcerative Colitis by Inducing the Autophagic Cell Death of Intestinal Epithelial.
Su W, Chen Y, Cao P, Chen Y, Guo Y, Wang S, Dong W
Frontiers in cellular and infection microbiology 2020;10:594806
Frontiers in cellular and infection microbiology 2020;10:594806
MicroRNA-1269a Promotes Proliferation and Arrest of Apoptosis of Glioma Cells by Directly Targeting ATRX.
Zhang Y, Wang Q, Luo N, Liu J, Ren H, Shao X, Zhang L, Yu Y
Frontiers in oncology 2020;10:563901
Frontiers in oncology 2020;10:563901
Long Non-coding RNA CCAT1 Acts as an Oncogene and Promotes Sunitinib Resistance in Renal Cell Carcinoma.
Shan L, Liu W, Zhan Y
Frontiers in oncology 2020;10:516552
Frontiers in oncology 2020;10:516552
Upregulated MELK Leads to Doxorubicin Chemoresistance and M2 Macrophage Polarization via the miR-34a/JAK2/STAT3 Pathway in Uterine Leiomyosarcoma.
Zhang Z, Sun C, Li C, Jiao X, Griffin BB, Dongol S, Wu H, Zhang C, Cao W, Dong R, Yang X, Zhang Q, Kong B
Frontiers in oncology 2020;10:453
Frontiers in oncology 2020;10:453
Verteporfin Is a Promising Anti-Tumor Agent for Cervical Carcinoma by Targeting Endoplasmic Reticulum Stress Pathway.
Wang M, Liu C, Li Y, Zhang Q, Zhu L, Fang Z, Jin L
Frontiers in oncology 2020;10:1781
Frontiers in oncology 2020;10:1781
Effect of epiberberine from Coptis chinensis Franch on inhibition of tumor growth in MKN-45 xenograft mice.
Yu M, Ren L, Liang F, Zhang Y, Jiang L, Ma W, Li C, Li X, Ye X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 Sep;76:153216
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 Sep;76:153216
Cetuximab enhances oridonin-induced apoptosis through mitochondrial pathway and endoplasmic reticulum stress in laryngeal squamous cell carcinoma cells.
Kang N, Cao S, Jiang B, Zhang Q, Donkor PO, Zhu Y, Qiu F, Gao X
Toxicology in vitro : an international journal published in association with BIBRA 2020 Sep;67:104885
Toxicology in vitro : an international journal published in association with BIBRA 2020 Sep;67:104885
GBP1 promotes erlotinib resistance via PGK1‑activated EMT signaling in non‑small cell lung cancer.
Cheng L, Gou L, Wei T, Zhang J
International journal of oncology 2020 Sep;57(3):858-870
International journal of oncology 2020 Sep;57(3):858-870
Hyperbaric oxygen treatment mitigates liver damage in mice with noise exposure.
Meng X, Zhang X, Su Y, Gu Z, Xie X, Chang Y, Bao J
Clinical and experimental pharmacology & physiology 2020 Sep;47(9):1564-1574
Clinical and experimental pharmacology & physiology 2020 Sep;47(9):1564-1574
Neferine induces apoptosis by modulating the ROS‑mediated JNK pathway in esophageal squamous cell carcinoma.
An K, Zhang Y, Liu Y, Yan S, Hou Z, Cao M, Liu G, Dong C, Gao J, Liu G
Oncology reports 2020 Sep;44(3):1116-1126
Oncology reports 2020 Sep;44(3):1116-1126
Cinnamaldehyde protects against rat intestinal ischemia/reperfusion injuries by synergistic inhibition of NF-κB and p53.
Almoiliqy M, Wen J, Xu B, Sun YC, Lian MQ, Li YL, Qaed E, Al-Azab M, Chen DP, Shopit A, Wang L, Sun PY, Lin Y
Acta pharmacologica Sinica 2020 Sep;41(9):1208-1222
Acta pharmacologica Sinica 2020 Sep;41(9):1208-1222
Curcumin inhibits the growth of triple-negative breast cancer cells by silencing EZH2 and restoring DLC1 expression.
Zhou X, Jiao D, Dou M, Zhang W, Lv L, Chen J, Li L, Wang L, Han X
Journal of cellular and molecular medicine 2020 Sep;24(18):10648-10662
Journal of cellular and molecular medicine 2020 Sep;24(18):10648-10662
Musashi2 promotes the progression of pancreatic cancer through a novel ISYNA1-p21/ZEB-1 pathway.
Zhou L, Sheng W, Jia C, Shi X, Cao R, Wang G, Lin Y, Zhu F, Dong Q, Dong M
Journal of cellular and molecular medicine 2020 Sep;24(18):10560-10572
Journal of cellular and molecular medicine 2020 Sep;24(18):10560-10572
FTO accelerates ovarian cancer cell growth by promoting proliferation, inhibiting apoptosis, and activating autophagy.
Zhao L, Kong X, Zhong W, Wang Y, Li P
Pathology, research and practice 2020 Sep;216(9):153042
Pathology, research and practice 2020 Sep;216(9):153042
Effect of CEACAM6 silencing on the biological behavior of human gallbladder cancer cells.
Tian C, Zhang B, Ge C
Oncology letters 2020 Sep;20(3):2677-2688
Oncology letters 2020 Sep;20(3):2677-2688
Mycobacterium tuberculosis infection increases the number of osteoclasts and inhibits osteoclast apoptosis by regulating TNF-α-mediated osteoclast autophagy.
Liu W, Zhou J, Niu F, Pu F, Wang Z, Huang M, Zhao X, Yang L, Tao P, Xia P, Feng J
Experimental and therapeutic medicine 2020 Sep;20(3):1889-1898
Experimental and therapeutic medicine 2020 Sep;20(3):1889-1898
BAIAP2L2 promotes the progression of gastric cancer via AKT/mTOR and Wnt3a/β-catenin signaling pathways.
Liu J, Shangguan Y, Sun J, Cong W, Xie Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Sep;129:110414
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Sep;129:110414
Synthesis, docking studies and antitumor activity of phenanthroimidazole derivatives as promising c-myc G-quadruplex DNA stabilizers.
Wu Q, Song Y, Liu R, Wang R, Mei W, Chen W, Yang H, Wang X
Bioorganic chemistry 2020 Sep;102:104074
Bioorganic chemistry 2020 Sep;102:104074
LAIR-1 suppresses cell growth of ovarian cancer cell via the PI3K-AKT-mTOR pathway.
Liu Y, Ma L, Shangguan F, Zhao X, Wang W, Gao Z, Zhou H, Qu G, Huang Y, An J, Xue J, Yang S, Cao Q
Aging 2020 Sep 5;12(16):16142-16154
Aging 2020 Sep 5;12(16):16142-16154
Dual Regulation of miR-34a and Notch Signaling in Triple-Negative Breast Cancer by Antibody/miRNA Nanocarriers.
Valcourt DM, Day ES
Molecular therapy. Nucleic acids 2020 Sep 4;21:290-298
Molecular therapy. Nucleic acids 2020 Sep 4;21:290-298
Porphyromonas gingivalis disrupts vascular endothelial homeostasis in a TLR-NF-κB axis dependent manner.
Xie M, Tang Q, Yu S, Sun J, Mei F, Zhao J, Chen L
International journal of oral science 2020 Sep 30;12(1):28
International journal of oral science 2020 Sep 30;12(1):28
Myricanol 5-fluorobenzyloxy ether regulation of survivin pathway inhibits human lung adenocarcinoma A549 cells growth in vitro.
Dai GH, Chen X, Ren ZM, Dai CJ, Tong YL, Chai KQ
BMC complementary medicine and therapies 2020 Sep 3;20(1):269
BMC complementary medicine and therapies 2020 Sep 3;20(1):269
Targeting DNA to the endoplasmic reticulum efficiently enhances gene delivery and therapy.
Qin B, Yuan X, Jiang M, Yin H, Luo Z, Zhang J, Zhu C, Li X, Shi Y, Luo L, Du Y, You J
Nanoscale 2020 Sep 21;12(35):18249-18262
Nanoscale 2020 Sep 21;12(35):18249-18262
Zinc oxide nanoparticles effectively regulate autophagic cell death by activating autophagosome formation and interfering with their maturation.
Liu Z, Lv X, Xu L, Liu X, Zhu X, Song E, Song Y
Particle and fibre toxicology 2020 Sep 18;17(1):46
Particle and fibre toxicology 2020 Sep 18;17(1):46
Reactive oxygen species mediate anlotinib-induced apoptosis via activation of endoplasmic reticulum stress in pancreatic cancer.
Yang L, Zhou X, Sun J, Lei Q, Wang Q, Pan D, Ding M, Ding Y
Cell death & disease 2020 Sep 17;11(9):766
Cell death & disease 2020 Sep 17;11(9):766
α-Cyperone inhibits the proliferation of human cervical cancer HeLa cells via ROS-mediated PI3K/Akt/mTOR signaling pathway.
Pei XD, Yao HL, Shen LQ, Yang Y, Lu L, Xiao JS, Wang XY, He ZL, Jiang LH
European journal of pharmacology 2020 Sep 15;883:173355
European journal of pharmacology 2020 Sep 15;883:173355
Inhibition of autophagy enhances timosaponin AIII-induced lung cancer cell apoptosis and anti-tumor effect in vitro and in vivo.
Liu J, Deng X, Sun X, Dong J, Huang J
Life sciences 2020 Sep 15;257:118040
Life sciences 2020 Sep 15;257:118040
Involvement of JNK/FOXO1 pathway in apoptosis induced by severe hypoxia in porcine granulosa cells.
Liu Z, Li C, Wu G, Li W, Zhang X, Zhou J, Zhang L, Tao J, Shen M, Liu H
Theriogenology 2020 Sep 15;154:120-127
Theriogenology 2020 Sep 15;154:120-127
Downregulation of CDC20 Increases Radiosensitivity through Mcl-1/p-Chk1-Mediated DNA Damage and Apoptosis in Tumor Cells.
Gao Y, Wen P, Chen B, Hu G, Wu L, Xu A, Zhao G
International journal of molecular sciences 2020 Sep 12;21(18)
International journal of molecular sciences 2020 Sep 12;21(18)
The AKT/GSK3-Mediated Slug Expression Contributes to Oxaliplatin Resistance in Colorectal Cancer via Upregulation of ERCC1.
Wei W, Ma XD, Jiang GM, Shi B, Zhong W, Sun CL, Zhao L, Hou YJ, Wang H
Oncology research 2020 Sep 1;28(4):423-438
Oncology research 2020 Sep 1;28(4):423-438
Puerarin ameliorates retinal ganglion cell damage induced by retinal ischemia/reperfusion through inhibiting the activation of TLR4/NLRP3 inflammasome.
Guan L, Li C, Zhang Y, Gong J, Wang G, Tian P, Shen N
Life sciences 2020 Sep 1;256:117935
Life sciences 2020 Sep 1;256:117935
Oncogenic gene RGC-32 is a direct target of miR-26b and facilitates tongue squamous cell carcinoma aggressiveness through EMT and PI3K/AKT signalling.
Yang ZH, Li J, Chen WZ, Kong FS
Cell biochemistry and function 2020 Oct;38(7):943-954
Cell biochemistry and function 2020 Oct;38(7):943-954
Potential hazardous effects of printing room PM2.5 exposure include promotion of lung inflammation and subsequent injury.
Zou C, Yang H, Cui L, Cao X, Huang H, Chen T
Molecular medicine reports 2020 Oct;22(4):3213-3224
Molecular medicine reports 2020 Oct;22(4):3213-3224
PRDX2 plays an oncogenic role in esophageal squamous cell carcinoma via Wnt/β-catenin and AKT pathways.
Feng AL, Han X, Meng X, Chen Z, Li Q, Shu W, Dai H, Zhu J, Yang Z
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2020 Oct;22(10):1838-1848
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2020 Oct;22(10):1838-1848
Micheliolide suppresses the viability, migration and invasion of U251MG cells via the NF-κB signaling pathway.
Feng D, Liu M, Liu Y, Zhao X, Sun H, Zheng X, Zhu J, Shang F
Oncology letters 2020 Oct;20(4):67
Oncology letters 2020 Oct;20(4):67
Inhibitory effect of Lycium barbarum polysaccharide on sperm damage during cryopreservation.
Yan B, Zhang X, Wang J, Jia S, Zhou Y, Tian J, Wang H, Tang Y
Experimental and therapeutic medicine 2020 Oct;20(4):3051-3063
Experimental and therapeutic medicine 2020 Oct;20(4):3051-3063
Long non-coding RNA MEG3 promotes cataractogenesis by upregulating TP53INP1 expression in age-related cataract.
Tu Y, Xie L, Chen L, Yuan Y, Qin B, Wang K, Zhu Q, Ji N, Zhu M, Guan H
Experimental eye research 2020 Oct;199:108185
Experimental eye research 2020 Oct;199:108185
Lowly expressed lncRNA PVT1 suppresses proliferation and advances apoptosis of glioma cells through up-regulating microRNA-128-1-5p and inhibiting PTBP1.
Dahai Z, Daliang C, Famu L, Xiang W, Lenian L, Jianmin C, Xiaobing X
Brain research bulletin 2020 Oct;163:1-13
Brain research bulletin 2020 Oct;163:1-13
STYK1 promotes autophagy through enhancing the assembly of autophagy-specific class III phosphatidylinositol 3-kinase complex I.
Zhou C, Qian X, Hu M, Zhang R, Liu N, Huang Y, Yang J, Zhang J, Bai H, Yang Y, Wang Y, Ali D, Michalak M, Chen XZ, Tang J
Autophagy 2020 Oct;16(10):1786-1806
Autophagy 2020 Oct;16(10):1786-1806
Evaluation of toxicity of halloysite nanotubes and multi-walled carbon nanotubes to endothelial cells in vitro and blood vessels in vivo.
Wu B, Jiang M, Liu X, Huang C, Gu Z, Cao Y
Nanotoxicology 2020 Oct;14(8):1017-1038
Nanotoxicology 2020 Oct;14(8):1017-1038
Huoxin pill attenuates myocardial infarction-induced apoptosis and fibrosis via suppression of p53 and TGF-β1/Smad2/3 pathways.
Shen Z, Shen A, Chen X, Wu X, Chu J, Cheng Y, Peng M, Chen Y, Weygant N, Wu M, Lin X, Peng J, Chen K
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Oct;130:110618
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Oct;130:110618
Identification of osalmid metabolic profile and active metabolites with anti-tumor activity in human hepatocellular carcinoma cells.
Wu Z, Zhan Y, Wang L, Tong J, Zhang L, Lin M, Jin X, Jiang L, Lou Y, Qiu Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Oct;130:110556
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Oct;130:110556
Empagliflozin improves diabetic renal tubular injury by alleviating mitochondrial fission via AMPK/SP1/PGAM5 pathway.
Liu X, Xu C, Xu L, Li X, Sun H, Xue M, Li T, Yu X, Sun B, Chen L
Metabolism: clinical and experimental 2020 Oct;111:154334
Metabolism: clinical and experimental 2020 Oct;111:154334
Hepcidin overexpression in astrocytes alters brain iron metabolism and protects against amyloid-β induced brain damage in mice.
Zhang X, Gou YJ, Zhang Y, Li J, Han K, Xu Y, Li H, You LH, Yu P, Chang YZ, Gao G
Cell death discovery 2020 Oct 30;6(1):113
Cell death discovery 2020 Oct 30;6(1):113
Activation of Sirtuin1 by lyceum barbarum polysaccharides in protection against diabetic cataract.
Yao Q, Zhou Y, Yang Y, Cai L, Xu L, Han X, Guo Y, Li PA
Journal of ethnopharmacology 2020 Oct 28;261:113165
Journal of ethnopharmacology 2020 Oct 28;261:113165
Rosmarinic Acid Alleviates Inflammation, Apoptosis, and Oxidative Stress through Regulating miR-155-5p in a Mice Model of Parkinson's Disease.
Lv R, Du L, Zhou F, Yuan X, Liu X, Zhang L
ACS chemical neuroscience 2020 Oct 21;11(20):3259-3266
ACS chemical neuroscience 2020 Oct 21;11(20):3259-3266
NO66 overexpression rescues ethanol-induced cell apoptosis in human AC16 cardiomyocytes by suppressing PTEN and activating the PI3K/Akt signaling.
Deng H, Yu B, Yu Y, Tian G, Yang L
Acta biochimica et biophysica Sinica 2020 Oct 19;52(10):1093-1101
Acta biochimica et biophysica Sinica 2020 Oct 19;52(10):1093-1101
BioID-based proteomic analysis of the Bid interactome identifies novel proteins involved in cell-cycle-dependent apoptotic priming.
Pedley R, King LE, Mallikarjun V, Wang P, Swift J, Brennan K, Gilmore AP
Cell death & disease 2020 Oct 16;11(10):872
Cell death & disease 2020 Oct 16;11(10):872
Hepatoprotective effects of Di Wu Yang Gan: A medicinal food against CCl(4)-induced hepatotoxicity in vivo and in vitro.
Xu W, Xiao M, Li J, Chen Y, Sun Q, Li H, Sun W
Food chemistry 2020 Oct 15;327:127093
Food chemistry 2020 Oct 15;327:127093
Melatonin suppresses ER stress-dependent proapoptotic effects via AMPK in bone mesenchymal stem cells during mitochondrial oxidative damage.
Fan C, Feng J, Tang C, Zhang Z, Feng Y, Duan W, Zhai M, Yan Z, Zhu L, Feng L, Zhu H, Luo E
Stem cell research & therapy 2020 Oct 15;11(1):442
Stem cell research & therapy 2020 Oct 15;11(1):442
Bta-miR-34b inhibits proliferation and promotes apoptosis via the MEK/ERK pathway by targeting MAP2K1 in bovine primary Sertoli cells.
Zhang L, Ma T, Tao Q, Tan W, Chen H, Liu W, Lin P, Zhou D, Wang A, Jin Y, Tang K
Journal of animal science 2020 Oct 1;98(10)
Journal of animal science 2020 Oct 1;98(10)
Polydatin executes anticancer effects against glioblastoma multiforme by inhibiting the EGFR-AKT/ERK1/2/STAT3-SOX2/Snail signaling pathway.
Chen Y, Niu J, Li L, Li Z, Jiang J, Zhu M, Dong T, Zhang J, Shi C, Xu P, Lu Y, Jiang Y, Liu P, Chen W
Life sciences 2020 Oct 1;258:118158
Life sciences 2020 Oct 1;258:118158
Echinacea polysaccharide alleviates LPS-induced lung injury via inhibiting inflammation, apoptosis and activation of the TLR4/NF-κB signal pathway.
Zhang H, Lang W, Wang S, Li B, Li G, Shi Q
International immunopharmacology 2020 Nov;88:106974
International immunopharmacology 2020 Nov;88:106974
Inhibition of B7-H4 promotes hepatocellular carcinoma cell apoptosis and autophagy through the PI3K signaling pathway.
Hao TT, Liao R, Lei DL, Hu GL, Luo F
International immunopharmacology 2020 Nov;88:106889
International immunopharmacology 2020 Nov;88:106889
CaMKII as a key regulator of contrast-induced nephropathy through mPTP opening in HK-2 cells.
Hu C, Zhou G, Liu K, Yin W, Zhou L, Wang J, Chen L, Zuo S, Xie Y, Zuo X
Cellular signalling 2020 Nov;75:109734
Cellular signalling 2020 Nov;75:109734
Induction of SPARC on Oxidative Stress, Inflammatory Phenotype Transformation, and Apoptosis of Human Brain Smooth Muscle Cells Via TGF-β1-NOX4 Pathway.
Tan X, Li T, Zhu S, Zhong W, Li F, Wang Y
Journal of molecular neuroscience : MN 2020 Nov;70(11):1728-1741
Journal of molecular neuroscience : MN 2020 Nov;70(11):1728-1741
miR-877-5p antagonizes the promoting effect of SP on the gastric cancer progression.
Guo XD, Zhang N, Sha L
Neoplasma 2020 Nov;67(6):1293-1302
Neoplasma 2020 Nov;67(6):1293-1302
miR-130a promotes immature porcine Sertoli cell growth by activating SMAD5 through the TGF-β-PI3K/AKT signaling pathway.
Luo H, Chen B, Weng B, Tang X, Chen Y, Yang A, Chu D, Zeng X, Ran M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Nov;34(11):15164-15179
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Nov;34(11):15164-15179
Development of a novel thymidylate synthase (TS) inhibitor capable of up-regulating P53 expression and inhibiting angiogenesis in NSCLC.
Li XY, Wang DP, Lu GQ, Liu KL, Zhang TJ, Li S, Mohamed O K, Xue WH, Qian XH, Meng FH
Journal of advanced research 2020 Nov;26:95-110
Journal of advanced research 2020 Nov;26:95-110
Pharmacological Effects of Fasudil on Flap Survival in a Rodent Model.
Ji E, Wang J, Wang L, Pan Z, Gao W
The Journal of surgical research 2020 Nov;255:575-582
The Journal of surgical research 2020 Nov;255:575-582
Mechanical stress regulates autophagic flux to affect apoptosis after spinal cord injury.
Zhang X, Jing Y, Qin C, Liu C, Yang D, Gao F, Yang M, Du L, Li J
Journal of cellular and molecular medicine 2020 Nov;24(21):12765-12776
Journal of cellular and molecular medicine 2020 Nov;24(21):12765-12776
Berberine protects against diabetic retinopathy by inhibiting cell apoptosis via deactivation of the NF‑κB signaling pathway.
Zhai J, Li Z, Zhang H, Ma L, Ma Z, Zhang Y, Zou J, Li M, Ma L, Wang X, Li X
Molecular medicine reports 2020 Nov;22(5):4227-4235
Molecular medicine reports 2020 Nov;22(5):4227-4235
miR‑155 modulates high glucose‑induced cardiac fibrosis via the Nrf2/HO‑1 signaling pathway.
Li Y, Duan JZ, He Q, Wang CQ
Molecular medicine reports 2020 Nov;22(5):4003-4016
Molecular medicine reports 2020 Nov;22(5):4003-4016
miR‑183‑5p attenuates cerebral ischemia injury by negatively regulating PTEN.
Zhu L, Zhou X, Li S, Liu J, Yang J, Fan X, Zhou S
Molecular medicine reports 2020 Nov;22(5):3944-3954
Molecular medicine reports 2020 Nov;22(5):3944-3954
MicroRNA‑22 regulates autophagy and apoptosis in cisplatin resistance of osteosarcoma.
Meng CY, Zhao ZQ, Bai R, Zhao W, Wang YX, Sun L, Sun C, Feng W, Guo SB
Molecular medicine reports 2020 Nov;22(5):3911-3921
Molecular medicine reports 2020 Nov;22(5):3911-3921
Agaricus blazei extract (FA-2-b-β) induces apoptosis in chronic myeloid leukemia cells.
Sun Y, Cheng M, Dong L, Yang K, Ma Z, Yu S, Yan P, Bai K, Zhu X, Zhang Q
Oncology letters 2020 Nov;20(5):270
Oncology letters 2020 Nov;20(5):270
Anthocyanins from Aronia melanocarpa Induce Apoptosis in Caco-2 Cells through Wnt/β-Catenin Signaling Pathway.
Wei J, Yu W, Hao R, Fan J, Gao J
Chemistry & biodiversity 2020 Nov;17(11):e2000654
Chemistry & biodiversity 2020 Nov;17(11):e2000654
Extracellular ubiquitin protects cardiomyocytes during ischemia/hypoxia by inhibiting mitochondrial apoptosis pathway through CXCR4.
Ji Y, Yao J, He Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Nov;131:110787
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Nov;131:110787
Pomegranate flower extract bidirectionally regulates the proliferation, differentiation and apoptosis of 3T3-L1 cells through regulation of PPARγ expression mediated by PI3K-AKT signaling pathway.
Li T, Zhang L, Jin C, Xiong Y, Cheng YY, Chen K
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Nov;131:110769
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Nov;131:110769
HAX1 enhances the survival and metastasis of non-small cell lung cancer through the AKT/mTOR and MDM2/p53 signaling pathway.
Liang Z, Zhong Y, Meng L, Chen Y, Liu Y, Wu A, Li X, Wang M
Thoracic cancer 2020 Nov;11(11):3155-3167
Thoracic cancer 2020 Nov;11(11):3155-3167
Mycoplasma bovis-generated reactive oxygen species and induced apoptosis in bovine mammary epithelial cell cultures.
Liu Y, Zhou M, Xu S, Khan MA, Shi Y, Qu W, Gao J, Liu G, Kastelic JP, Han B
Journal of dairy science 2020 Nov;103(11):10429-10445
Journal of dairy science 2020 Nov;103(11):10429-10445
TMEM176A acts as a tumor suppressor gene in pancreatic cancer by inhibiting ERK signaling.
Guo Y, Cao F, Hu S, Liu S, Sun H, Li A, Li F
Discovery medicine 2020 Nov-Dec;30(161):145-153
Discovery medicine 2020 Nov-Dec;30(161):145-153
CDK5RAP3, a Novel Nucleoplasmic Shuttle, Deeply Regulates HSF1-Mediated Heat Stress Response and Protects Mammary Epithelial Cells from Heat Injury.
Shen Y, Zou Y, Li J, Chen F, Li H, Cai Y
International journal of molecular sciences 2020 Nov 9;21(21)
International journal of molecular sciences 2020 Nov 9;21(21)
[IL-17A/lL-17RA reduces cisplatin sensitivity of ovarian cancer SKOV3 cells by regulating autophagy].
Wang L, Zhang X, Wang L, Wang B, Zhang J, Li Y
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2020 Nov 30;40(11):1550-1556
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2020 Nov 30;40(11):1550-1556
Sesn2 attenuates the damage of endothelial progenitor cells induced by angiotensin II through regulating the Keap1/Nrf2 signal pathway.
Ding S, Ma N, Liu H, Tang M, Mei J
Aging 2020 Nov 24;12(24):25505-25527
Aging 2020 Nov 24;12(24):25505-25527
SRT2183 impairs ovarian cancer by facilitating autophagy.
Sun T, Hu Y, He W, Shang Y, Yang X, Gong L, Zhang X, Gong P, Yang G
Aging 2020 Nov 20;12(23):24208-24218
Aging 2020 Nov 20;12(23):24208-24218
Oxidative stress mediates age-related hypertrophy of ligamentum flavum by inducing inflammation, fibrosis, and apoptosis through activating Akt and MAPK pathways.
Chuang HC, Tsai KL, Tsai KJ, Tu TY, Shyong YJ, Jou IM, Hsu CC, Shih SS, Liu YF, Lin CL
Aging 2020 Nov 20;12(23):24168-24183
Aging 2020 Nov 20;12(23):24168-24183
Ranolazine protects against diabetic cardiomyopathy by activating the NOTCH1/NRG1 pathway.
Chen X, Ren L, Liu X, Sun X, Dong C, Jiang Y, Qin Y, Qu H, Jiao J, Wang S, Bai Y, Yang B
Life sciences 2020 Nov 15;261:118306
Life sciences 2020 Nov 15;261:118306
Design and synthesis of novel Flavone-based histone deacetylase inhibitors antagonizing activation of STAT3 in breast cancer.
Wei M, Xie M, Zhang Z, Wei Y, Zhang J, Pan H, Li B, Wang J, Song Y, Chong C, Zhao R, Wang J, Yu L, Yang G, Yang C
European journal of medicinal chemistry 2020 Nov 15;206:112677
European journal of medicinal chemistry 2020 Nov 15;206:112677
Targeted inhibition of GRP78 by HA15 promotes apoptosis of lung cancer cells accompanied by ER stress and autophagy.
Wu J, Wu Y, Lian X
Biology open 2020 Nov 12;9(11)
Biology open 2020 Nov 12;9(11)
Acupuncture protects against cerebral ischemia-reperfusion injury via suppressing endoplasmic reticulum stress-mediated autophagy and apoptosis.
Sun X, Liu H, Sun Z, Zhang B, Wang X, Liu T, Pan T, Gao Y, Jiang X, Li H
Molecular medicine (Cambridge, Mass.) 2020 Nov 10;26(1):105
Molecular medicine (Cambridge, Mass.) 2020 Nov 10;26(1):105
Hesperidin ameliorates hypobaric hypoxia-induced retinal impairment through activation of Nrf2/HO-1 pathway and inhibition of apoptosis.
Xin X, Li Y, Liu H
Scientific reports 2020 Nov 10;10(1):19426
Scientific reports 2020 Nov 10;10(1):19426
Morusin induces apoptosis and autophagy via JNK, ERK and PI3K/Akt signaling in human lung carcinoma cells.
Wang J, Liu X, Zheng H, Liu Q, Zhang H, Wang X, Shen T, Wang S, Ren D
Chemico-biological interactions 2020 Nov 1;331:109279
Chemico-biological interactions 2020 Nov 1;331:109279
E3 ubiquitin ligase TRIM7 negatively regulates NF-kappa B signaling pathway by degrading p65 in lung cancer.
Jin J, Lu Z, Wang X, Liu Y, Han T, Wang Y, Wang T, Gan M, Xie C, Wang J, Yu B
Cellular signalling 2020 May;69:109543
Cellular signalling 2020 May;69:109543
miR-362 knock-down promotes proliferation and inhibits apoptosis in porcine immature Sertoli cells by targeting the RMI1 gene.
Ran M, Luo H, Gao H, Tang X, Chen Y, Zeng X, Weng B, Chen B
Reproduction in domestic animals = Zuchthygiene 2020 May;55(5):547-558
Reproduction in domestic animals = Zuchthygiene 2020 May;55(5):547-558
LINC00963 targeting miR-128-3p promotes acute kidney injury process by activating JAK2/STAT1 pathway.
Xie LB, Chen B, Liao X, Chen YF, Yang R, He SR, Pei LJ, Jiang R
Journal of cellular and molecular medicine 2020 May;24(10):5555-5564
Journal of cellular and molecular medicine 2020 May;24(10):5555-5564
Altered circadian clock as a novel therapeutic target for constant darkness-induced insulin resistance and hyperandrogenism of polycystic ovary syndrome.
Li S, Zhai J, Chu W, Geng X, Chen ZJ, Du Y
Translational research : the journal of laboratory and clinical medicine 2020 May;219:13-29
Translational research : the journal of laboratory and clinical medicine 2020 May;219:13-29
Palmatine induces G2/M phase arrest and mitochondrial-associated pathway apoptosis in colon cancer cells by targeting AURKA.
Liu X, Zhang Y, Wu S, Xu M, Shen Y, Yu M, Fan J, Wei S, Xu C, Huang L, Zhao H, Li X, Ye X
Biochemical pharmacology 2020 May;175:113933
Biochemical pharmacology 2020 May;175:113933
Silencing METTL3 inhibits the proliferation and invasion of osteosarcoma by regulating ATAD2.
Zhou L, Yang C, Zhang N, Zhang X, Zhao T, Yu J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 May;125:109964
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 May;125:109964
KIF2A promotes the progression via AKT signaling pathway and is upregulated by transcription factor ETV4 in human gastric cancer.
Zhang X, Wang Y, Liu X, Zhao A, Yang Z, Kong F, Sun L, Yu Y, Jiang L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 May;125:109840
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 May;125:109840
MicroRNA-375-3p enhances chemosensitivity to 5-fluorouracil by targeting thymidylate synthase in colorectal cancer.
Xu F, Ye ML, Zhang YP, Li WJ, Li MT, Wang HZ, Qiu X, Xu Y, Yin JW, Hu Q, Wei WH, Chang Y, Liu L, Zhao Q
Cancer science 2020 May;111(5):1528-1541
Cancer science 2020 May;111(5):1528-1541
Pyruvate alleviates high glucose-induced endoplasmic reticulum stress and apoptosis in HK-2 cells.
Zhang XM, Wang YZ, Tong JD, Ning XC, Zhou FQ, Yang XH, Jin HM
FEBS open bio 2020 May;10(5):827-834
FEBS open bio 2020 May;10(5):827-834
Astragaloside IV enhances GATA-4 mediated myocardial protection effect in hypoxia/reoxygenation injured H9c2 cells.
Yang JJ, Zhang XH, Ma XH, Duan WJ, Xu NG, Chen YJ, Liang L
Nutrition, metabolism, and cardiovascular diseases : NMCD 2020 May 7;30(5):829-842
Nutrition, metabolism, and cardiovascular diseases : NMCD 2020 May 7;30(5):829-842
Arsenic trioxide ameliorates experimental autoimmune encephalomyelitis in C57BL/6 mice by inducing CD4(+) T cell apoptosis.
An K, Xue MJ, Zhong JY, Yu SN, Lan TS, Qi ZQ, Xia JJ
Journal of neuroinflammation 2020 May 6;17(1):147
Journal of neuroinflammation 2020 May 6;17(1):147
MAY, a novel tubulin inhibitor, induces cell apoptosis in A549 and A549/Taxol cells and inhibits epithelial-mesenchymal transition in A549/Taxol cells.
Du J, Li J, Gao M, Guan Q, Liu T, Wu Y, Li Z, Zuo D, Zhang W, Wu Y
Chemico-biological interactions 2020 May 25;323:109074
Chemico-biological interactions 2020 May 25;323:109074
Bismuth Porphyrin Antagonizes Cisplatin-Induced Nephrotoxicity via Unexpected Metallothionein-Independent Mechanisms.
Wang R, Wang S, Chan S, Wang Y, Zhang Y, Zuo Z, Chi-Fung Chan G, Li H, Sun H
iScience 2020 May 22;23(5):101054
iScience 2020 May 22;23(5):101054
Butyrate alleviates oxidative stress by regulating NRF2 nuclear accumulation and H3K9/14 acetylation via GPR109A in bovine mammary epithelial cells and mammary glands.
Guo W, Liu J, Sun J, Gong Q, Ma H, Kan X, Cao Y, Wang J, Fu S
Free radical biology & medicine 2020 May 20;152:728-742
Free radical biology & medicine 2020 May 20;152:728-742
MS-275 combined with cisplatin exerts synergistic antitumor effects in human esophageal squamous cell carcinoma cells.
Liu T, Guan F, Wang Y, Zhang Z, Li Y, Cui Y, Li Z, Liu H, Zhang Y, Wang Y, Ma S
Toxicology and applied pharmacology 2020 May 15;395:114971
Toxicology and applied pharmacology 2020 May 15;395:114971
CUL4 E3 ligase regulates the proliferation and apoptosis of lung squamous cell carcinoma and small cell lung carcinoma.
Li T, Wu S, Jia L, Cao W, Yao Y, Zhao G, Li H
Cancer biology & medicine 2020 May 15;17(2):357-370
Cancer biology & medicine 2020 May 15;17(2):357-370
MiR-193b-5p inhibits proliferation and enhances radio-sensitivity by downregulating the AKT/mTOR signaling pathway in tongue cancer.
Jiang L, He C, Zhang X, Chen Y, Li G
Translational cancer research 2020 Mar;9(3):1851-1860
Translational cancer research 2020 Mar;9(3):1851-1860
Rosmarinic acid exerts an anticancer effect on osteosarcoma cells by inhibiting DJ-1 via regulation of the PTEN-PI3K-Akt signaling pathway.
Ma Z, Yang J, Yang Y, Wang X, Chen G, Shi A, Lu Y, Jia S, Kang X, Lu L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 Mar;68:153186
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 Mar;68:153186
Silencing of TPD52 inhibits proliferation, migration, invasion but induces apoptosis of pancreatic cancer cells by deactivating Akt pathway.
Wang Z, Li Y, Fan L, Zhao Q, Tan B, Liu R, Li F
Neoplasma 2020 Mar;67(2):277-285
Neoplasma 2020 Mar;67(2):277-285
Characterization of HTATIP2 and its role during hair follicle cycles in Angora rabbit.
Zhao B, Chen Y, Hu S, Yang N, Liu M, Li J, Bao Z, Wu X
Genome 2020 Mar;63(3):179-187
Genome 2020 Mar;63(3):179-187
HJC0152 suppresses human non-small-cell lung cancer by inhibiting STAT3 and modulating metabolism.
Lu L, Li H, Wu X, Rao J, Zhou J, Fan S, Shen Q
Cell proliferation 2020 Mar;53(3):e12777
Cell proliferation 2020 Mar;53(3):e12777
Resveratrol protects the integrity of alveolar epithelial barrier via SIRT1/PTEN/p-Akt pathway in methamphetamine-induced chronic lung injury.
Wang X, Liu M, Zhu MJ, Shi L, Liu L, Zhao YL, Cheng L, Gu YJ, Zhou MY, Chen L, Kumar A, Wang Y
Cell proliferation 2020 Mar;53(3):e12773
Cell proliferation 2020 Mar;53(3):e12773
Do You Know the Details of Your PAX8 Antibody? Monoclonal PAX8 (MRQ-50) Is Not Expressed in a Series of 45 Medullary Thyroid Carcinomas.
Gucer H, Caliskan S, Kefeli M, Mete O
Endocrine pathology 2020 Mar;31(1):33-38
Endocrine pathology 2020 Mar;31(1):33-38
Acrolein-induced apoptosis of smooth muscle cells through NEAT1-Bmal1/Clock pathway and a protection from asparagus extract.
Chen L, Wu X, Zeb F, Huang Y, An J, Jiang P, Chen A, Xu C, Feng Q
Environmental pollution (Barking, Essex : 1987) 2020 Mar;258:113735
Environmental pollution (Barking, Essex : 1987) 2020 Mar;258:113735
Blockade of HSP70 by VER-155008 synergistically enhances bortezomib-induced cytotoxicity in multiple myeloma.
Huang L, Wang Y, Bai J, Yang Y, Wang F, Feng Y, Zhang R, Li F, Zhang P, Lv N, Lei L, Hu J, He A
Cell stress & chaperones 2020 Mar;25(2):357-367
Cell stress & chaperones 2020 Mar;25(2):357-367
C. sakazakii activates AIM2 pathway accompanying with excessive ER stress response in mammalian mammary gland epithelium.
Song W, Sheng L, Chen F, Tian Y, Li L, Wang G, Li H, Cai Y
Cell stress & chaperones 2020 Mar;25(2):223-233
Cell stress & chaperones 2020 Mar;25(2):223-233
Melatonin attenuates doxorubicin-induced cardiotoxicity through preservation of YAP expression.
Li HR, Wang C, Sun P, Liu DD, Du GQ, Tian JW
Journal of cellular and molecular medicine 2020 Mar;24(6):3634-3646
Journal of cellular and molecular medicine 2020 Mar;24(6):3634-3646
Dioscin inhibits the growth of human osteosarcoma by inducing G2/M-phase arrest, apoptosis, and GSDME-dependent cell death in vitro and in vivo.
Ding Q, Zhang W, Cheng C, Mo F, Chen L, Peng G, Cai X, Wang J, Yang S, Liu X
Journal of cellular physiology 2020 Mar;235(3):2911-2924
Journal of cellular physiology 2020 Mar;235(3):2911-2924
Knockdown of lncRNA MIR503HG suppresses proliferation and promotes apoptosis of non-small cell lung cancer cells by regulating miR-489-3p and miR-625-5p.
Dao R, Wudu M, Hui L, Jiang J, Xu Y, Ren H, Qiu X
Pathology, research and practice 2020 Mar;216(3):152823
Pathology, research and practice 2020 Mar;216(3):152823
CHAF1B induces radioresistance by promoting DNA damage repair in nasopharyngeal carcinoma.
Di M, Wang M, Miao J, Chen B, Huang H, Lin C, Jian Y, Li Y, Ouyang Y, Chen X, Wang L, Zhao C
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Mar;123:109748
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Mar;123:109748
The mechanism of PDA/PEI/5-Fu coated esophageal stent material on inhibiting cancer associated pathological cells.
Zhang K, Bai Y, Xu R, Li J, Guan F
Journal of biomedical materials research. Part A 2020 Mar;108(3):814-821
Journal of biomedical materials research. Part A 2020 Mar;108(3):814-821
Layer-by-layer assembled PLGA nanoparticles carrying miR-34a cargo inhibit the proliferation and cell cycle progression of triple-negative breast cancer cells.
Kapadia CH, Ioele SA, Day ES
Journal of biomedical materials research. Part A 2020 Mar;108(3):601-613
Journal of biomedical materials research. Part A 2020 Mar;108(3):601-613
MicroRNA-217-5p ameliorates endothelial cell apoptosis induced by ox-LDL by targeting CLIC4.
Zhang X, Wang Z, Li W, Huang R, Zheng D, Bi G
Nutrition, metabolism, and cardiovascular diseases : NMCD 2020 Mar 9;30(3):523-533
Nutrition, metabolism, and cardiovascular diseases : NMCD 2020 Mar 9;30(3):523-533
Novel HSP90-PI3K Dual Inhibitor Suppresses Melanoma Cell Proliferation by Interfering with HSP90-EGFR Interaction and Downstream Signaling Pathways.
Zhao Q, Zhu HP, Xie X, Mao Q, Liu YQ, He XH, Peng C, Jiang QL, Huang W
International journal of molecular sciences 2020 Mar 7;21(5)
International journal of molecular sciences 2020 Mar 7;21(5)
High Glucose Induces Mesangial Cell Apoptosis through miR-15b-5p and Promotes Diabetic Nephropathy by Extracellular Vesicle Delivery.
Tsai YC, Kuo MC, Hung WW, Wu LY, Wu PH, Chang WA, Kuo PL, Hsu YL
Molecular therapy : the journal of the American Society of Gene Therapy 2020 Mar 4;28(3):963-974
Molecular therapy : the journal of the American Society of Gene Therapy 2020 Mar 4;28(3):963-974
Long non-coding RNA HAL suppresses the migration and invasion of serous ovarian cancer by inhibiting EMT signaling pathway.
Wu K, Li L, Li L, Wang D
Bioscience reports 2020 Mar 27;40(3)
Bioscience reports 2020 Mar 27;40(3)
Nanoparticle-Mediated Co-Delivery of Notch-1 Antibodies and ABT-737 as a Potent Treatment Strategy for Triple-Negative Breast Cancer.
Valcourt DM, Dang MN, Scully MA, Day ES
ACS nano 2020 Mar 24;14(3):3378-3388
ACS nano 2020 Mar 24;14(3):3378-3388
LncRNA HCP5 promotes cell proliferation and inhibits apoptosis via miR-27a-3p/IGF-1 axis in human granulosa-like tumor cell line KGN.
Chen Y, Zhang X, An Y, Liu B, Lu M
Molecular and cellular endocrinology 2020 Mar 1;503:110697
Molecular and cellular endocrinology 2020 Mar 1;503:110697
MicroRNA-145 suppresses gastric cancer progression by targeting Hu-antigen R.
Li Q, Tong D, Guo C, Wu F, Li F, Wang X, Jiang Q, Wei Y, Liu L, Ni L, Guo B, Huang C
American journal of physiology. Cell physiology 2020 Mar 1;318(3):C605-C614
American journal of physiology. Cell physiology 2020 Mar 1;318(3):C605-C614
Discovery of novel akt1 inhibitor induces autophagy associated death in hepatocellular carcinoma cells.
Yu M, Zeng M, Pan Z, Wu F, Guo L, He G
European journal of medicinal chemistry 2020 Mar 1;189:112076
European journal of medicinal chemistry 2020 Mar 1;189:112076
4-hydroxybenzo[d]oxazol-2(3H)-one ameliorates LPS/D-GalN-induced acute liver injury by inhibiting TLR4/NF-κB and MAPK signaling pathways in mice.
Wang H, Wei X, Wei X, Sun X, Huang X, Liang Y, Xu W, Zhu X, Lin X, Lin J
International immunopharmacology 2020 Jun;83:106445
International immunopharmacology 2020 Jun;83:106445
MANF Promotes Diabetic Corneal Epithelial Wound Healing and Nerve Regeneration by Attenuating Hyperglycemia-Induced Endoplasmic Reticulum Stress.
Wang X, Li W, Zhou Q, Li J, Wang X, Zhang J, Li D, Qi X, Liu T, Zhao X, Li S, Yang L, Xie L
Diabetes 2020 Jun;69(6):1264-1278
Diabetes 2020 Jun;69(6):1264-1278
Dihydromethysticin, a natural molecule from Kava, suppresses the growth of colorectal cancer via the NLRC3/PI3K pathway.
Pan H, Liu F, Wang J, Zhao M, Wang D, Jia C, Wang T, Chen Z, Fan Y, Liang D, Meng Q
Molecular carcinogenesis 2020 Jun;59(6):575-589
Molecular carcinogenesis 2020 Jun;59(6):575-589
Compositional characterization of Pyrus ussuriensis Maxim and their antioxidant activities and induction of apoptosis in Bel-7402 cell.
Peng F, Li G, Xie Y, Yin HY, Li XJ, Yang YD
Journal of food biochemistry 2020 Jun;44(6):e13222
Journal of food biochemistry 2020 Jun;44(6):e13222
Triptolide interrupts rRNA synthesis and induces the RPL23‑MDM2‑p53 pathway to repress lung cancer cells.
Wang J, Zhang ZQ, Li FQ, Chen JN, Gong X, Cao BB, Wang W
Oncology reports 2020 Jun;43(6):1863-1874
Oncology reports 2020 Jun;43(6):1863-1874
Upregulation of miR-219a-5p Decreases Cerebral Ischemia/Reperfusion Injury In Vitro by Targeting Pde4d.
Lu MY, Wu JR, Liang RB, Wang YP, Zhu YC, Ma ZT, Zhang H, Zan J, Tan W
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2020 Jun;29(6):104801
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2020 Jun;29(6):104801
Overexpressed microRNA-494 represses RIPK1 to attenuate hippocampal neuron injury in epilepsy rats by inactivating the NF-κB signaling pathway.
Qi Y, Qian R, Jia L, Fei X, Zhang D, Zhang Y, Jiang S, Fu X
Cell cycle (Georgetown, Tex.) 2020 Jun;19(11):1298-1313
Cell cycle (Georgetown, Tex.) 2020 Jun;19(11):1298-1313
Chemopreventive effect of Betulinic acid via mTOR -Caspases/Bcl2/Bax apoptotic signaling in pancreatic cancer.
Guo Y, Zhu H, Weng M, Wang C, Sun L
BMC complementary medicine and therapies 2020 Jun 8;20(1):178
BMC complementary medicine and therapies 2020 Jun 8;20(1):178
lncRNA MIRF Promotes Cardiac Apoptosis through the miR-26a-Bak1 Axis.
Su X, Lv L, Li Y, Fang R, Yang R, Li C, Li T, Zhu D, Li X, Zhou Y, Shan H, Liang H
Molecular therapy. Nucleic acids 2020 Jun 5;20:841-850
Molecular therapy. Nucleic acids 2020 Jun 5;20:841-850
SIRT3 increases cisplatin sensitivity of small-cell lung cancer through apoptosis.
Guo R, Li Y, Xue Y, Chen Y, Li J, Deng X, Su J, Liu Y, Sun L
Gene 2020 Jun 30;745:144629
Gene 2020 Jun 30;745:144629
Glycosylation end products mediate damage and apoptosis of periodontal ligament stem cells induced by the JNK-mitochondrial pathway.
Fang H, Yang K, Tang P, Zhao N, Ma R, Luo X, Liu Q
Aging 2020 Jun 30;12(13):12850-12868
Aging 2020 Jun 30;12(13):12850-12868
Radiation-Induced DNMT3B Promotes Radioresistance in Nasopharyngeal Carcinoma through Methylation of p53 and p21.
Wu C, Guo E, Ming J, Sun W, Nie X, Sun L, Peng S, Luo M, Liu D, Zhang L, Mei Q, Long G, Hu G, Hu G
Molecular therapy oncolytics 2020 Jun 26;17:306-319
Molecular therapy oncolytics 2020 Jun 26;17:306-319
YBX1 mediates autophagy by targeting p110β and decreasing the sensitivity to cisplatin in NSCLC.
Cui Y, Li F, Xie Q, Zhao S, Guo T, Guo P, Hu S, Hao J, Tian C, Yu W, Li Z, Fang L, Zhao L, Chen M, Wu T, Gu C
Cell death & disease 2020 Jun 19;11(6):476
Cell death & disease 2020 Jun 19;11(6):476
Rosmarinic acid exerts a neuroprotective effect on spinal cord injury by suppressing oxidative stress and inflammation via modulating the Nrf2/HO-1 and TLR4/NF-κB pathways.
Ma Z, Lu Y, Yang F, Li S, He X, Gao Y, Zhang G, Ren E, Wang Y, Kang X
Toxicology and applied pharmacology 2020 Jun 15;397:115014
Toxicology and applied pharmacology 2020 Jun 15;397:115014
Non-Esterified Fatty Acid-Induced Reactive Oxygen Species Mediated Granulosa Cells Apoptosis Is Regulated by Nrf2/p53 Signaling Pathway.
Wang Y, Li C, Li J, Wang G, Li L
Antioxidants (Basel, Switzerland) 2020 Jun 14;9(6)
Antioxidants (Basel, Switzerland) 2020 Jun 14;9(6)
Resveratrol inhibits the malignant progression of hepatocellular carcinoma via MARCH1-induced regulation of PTEN/AKT signaling.
Dai H, Li M, Yang W, Sun X, Wang P, Wang X, Su J, Wang X, Hu X, Zhao M
Aging 2020 Jun 12;12(12):11717-11731
Aging 2020 Jun 12;12(12):11717-11731
Cyclovirobuxine D inhibits colorectal cancer tumorigenesis via the CTHRC1‑AKT/ERK‑Snail signaling pathway.
Jiang F, Chen Y, Ren S, Li Z, Sun K, Xing Y, Zhu Y, Piao D
International journal of oncology 2020 Jul;57(1):183-196
International journal of oncology 2020 Jul;57(1):183-196
4-Phenylbutyrate Prevents Endoplasmic Reticulum Stress-Mediated Apoptosis Induced by Heatstroke in the Intestines of Mice.
Cao Y, Liu Z, Xiao W, Gu Z, Xiao G, Yuan F, Chen F, Pei Y, Li H, Su L
Shock (Augusta, Ga.) 2020 Jul;54(1):102-109
Shock (Augusta, Ga.) 2020 Jul;54(1):102-109
PCNP promotes ovarian cancer progression by accelerating β-catenin nuclear accumulation and triggering EMT transition.
Dong P, Fu H, Chen L, Zhang S, Zhang X, Li H, Wu D, Ji X
Journal of cellular and molecular medicine 2020 Jul;24(14):8221-8235
Journal of cellular and molecular medicine 2020 Jul;24(14):8221-8235
CUDC-907, a novel dual PI3K and HDAC inhibitor, in prostate cancer: Antitumour activity and molecular mechanism of action.
Hu C, Xia H, Bai S, Zhao J, Edwards H, Li X, Yang Y, Lyu J, Wang G, Zhan Y, Dong Y, Ge Y
Journal of cellular and molecular medicine 2020 Jul;24(13):7239-7253
Journal of cellular and molecular medicine 2020 Jul;24(13):7239-7253
lncRNA KCNQ1OT1 knockdown inhibits colorectal cancer cell proliferation, migration and invasiveness via the PI3K/AKT pathway.
Duan Q, Cai L, Zheng K, Cui C, Huang R, Zheng Z, Xie L, Wu C, Yu X, Yu J
Oncology letters 2020 Jul;20(1):601-610
Oncology letters 2020 Jul;20(1):601-610
Vitamin D3 mediates miR-15a-5p inhibition of liver cancer cell proliferation via targeting E2F3.
Li Y, Lin Q, Chang S, Zhang R, Wang J
Oncology letters 2020 Jul;20(1):292-298
Oncology letters 2020 Jul;20(1):292-298
ZX-29, a novel ALK inhibitor, induces apoptosis via ER stress in ALK rearrangement NSCLC cells and overcomes cell resistance caused by an ALK mutation.
Gou W, Li Z, Xu X, Shen J, Guo M, Zhou X, Zhang X, Wu Y, Zhai X, Zuo D
Biochimica et biophysica acta. Molecular cell research 2020 Jul;1867(7):118712
Biochimica et biophysica acta. Molecular cell research 2020 Jul;1867(7):118712
MicroRNA-26a-5p alleviates neuronal apoptosis and brain injury in intracerebral hemorrhage by targeting RAN binding protein 9.
Zhang H, Lu X, Hao Y, Tang L, He Z
Acta histochemica 2020 Jul;122(5):151571
Acta histochemica 2020 Jul;122(5):151571
PD-L1 promotes tumor growth and progression by activating WIP and β-catenin signaling pathways and predicts poor prognosis in lung cancer.
Yu W, Hua Y, Qiu H, Hao J, Zou K, Li Z, Hu S, Guo P, Chen M, Sui S, Xiong Y, Li F, Lu J, Guo W, Luo G, Deng W
Cell death & disease 2020 Jul 6;11(7):506
Cell death & disease 2020 Jul 6;11(7):506
Epigenetic upregulation of HOXC10 in non-small lung cancer cells.
Li M, Alsager JS, Wang Z, Cheng L, Shan B
Aging 2020 Jul 19;12(17):16921-16935
Aging 2020 Jul 19;12(17):16921-16935
Circ-ADAM9 targeting PTEN and ATG7 promotes autophagy and apoptosis of diabetic endothelial progenitor cells by sponging mir-20a-5p.
Tian D, Xiang Y, Tang Y, Ge Z, Li Q, Zhang Y
Cell death & disease 2020 Jul 13;11(7):526
Cell death & disease 2020 Jul 13;11(7):526
Design, synthesis and biological evaluation of homoerythrina alkaloid derivatives bearing a triazole moiety as PARP-1 inhibitors and as potential antitumor drugs.
Li S, Li XY, Zhang TJ, Kamara MO, Liang JW, Zhu J, Meng FH
Bioorganic chemistry 2020 Jan;94:103385
Bioorganic chemistry 2020 Jan;94:103385
Withaferin A triggers G2/M arrest and intrinsic apoptosis in glioblastoma cells via ATF4-ATF3-CHOP axis.
Tang Q, Ren L, Liu J, Li W, Zheng X, Wang J, Du G
Cell proliferation 2020 Jan;53(1):e12706
Cell proliferation 2020 Jan;53(1):e12706
Aconitine induces cardiomyocyte damage by mitigating BNIP3-dependent mitophagy and the TNFα-NLRP3 signalling axis.
Peng F, Zhang N, Wang C, Wang X, Huang W, Peng C, He G, Han B
Cell proliferation 2020 Jan;53(1):e12701
Cell proliferation 2020 Jan;53(1):e12701
LncRNA MYCNOS facilitates proliferation and invasion in hepatocellular carcinoma by regulating miR-340.
Yu J, Ou Z, Lei Y, Chen L, Su Q, Zhang K
Human cell 2020 Jan;33(1):148-158
Human cell 2020 Jan;33(1):148-158
LINC00365-SCGB2A1 axis inhibits the viability of breast cancer through targeting NF-κB signaling.
Zhang L, Yan X, Yu S, Zhong X, Tian R, Xu L, Bian X, Su J
Oncology letters 2020 Jan;19(1):753-762
Oncology letters 2020 Jan;19(1):753-762
Long noncoding RNA CA7-4 promotes autophagy and apoptosis via sponging MIR877-3P and MIR5680 in high glucose-induced vascular endothelial cells.
Zhao X, Su L, He X, Zhao B, Miao J
Autophagy 2020 Jan;16(1):70-85
Autophagy 2020 Jan;16(1):70-85
Long noncoding RNA CASC21 exerts an oncogenic role in colorectal cancer through regulating miR-7-5p/YAP1 axis.
Zheng Y, Nie P, Xu S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jan;121:109628
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jan;121:109628
Enhanced UV Resistance Role of Death Domain-Associated Protein in Human MDA-MB-231 Breast Cancer Cells by Regulation of G2 DNA Damage Checkpoint.
Shan Z, Liu L, Shen J, Hao H, Zhang H, Lei L, Liu F, Wang Z
Cell transplantation 2020 Jan-Dec;29:963689720920277
Cell transplantation 2020 Jan-Dec;29:963689720920277
Desloratadine, a Novel Antigrowth Reagent for Bladder Cancer.
Ma J, Qi J, Li S, Zhang C, Wang H, Shao L, Yuan X, Sha Q
Technology in cancer research & treatment 2020 Jan-Dec;19:1533033820926591
Technology in cancer research & treatment 2020 Jan-Dec;19:1533033820926591
Knockdown of Rab9 Suppresses the Progression of Gastric Cancer Through Regulation of Akt Signaling Pathway.
Zhu Y, Shi F, Wang M, Ding J
Technology in cancer research & treatment 2020 Jan-Dec;19:1533033820915958
Technology in cancer research & treatment 2020 Jan-Dec;19:1533033820915958
Trehalose Alleviates Crystalline Silica-Induced Pulmonary Fibrosis via Activation of the TFEB-Mediated Autophagy-Lysosomal System in Alveolar Macrophages.
He X, Chen S, Li C, Ban J, Wei Y, He Y, Liu F, Chen Y, Chen J
Cells 2020 Jan 4;9(1)
Cells 2020 Jan 4;9(1)
Lycorine Induces autophagy-associated apoptosis by targeting MEK2 and enhances vemurafenib activity in colorectal cancer.
Hu M, Yu Z, Mei P, Li J, Luo D, Zhang H, Zhou M, Liang F, Chen R
Aging 2020 Jan 3;12(1):138-155
Aging 2020 Jan 3;12(1):138-155
Ginsenoside Rk1 induces apoptosis and downregulates the expression of PD-L1 by targeting the NF-κB pathway in lung adenocarcinoma.
Hu M, Yang J, Qu L, Deng X, Duan Z, Fu R, Liang L, Fan D
Food & function 2020 Jan 29;11(1):456-471
Food & function 2020 Jan 29;11(1):456-471
Calcium relieves fluoride-induced bone damage through the PI3K/AKT pathway.
Wang J, Xu H, Cheng X, Yang J, Yan Z, Ma H, Zhao Y, Ommati MM, Manthari RK, Wang J
Food & function 2020 Jan 29;11(1):1155-1164
Food & function 2020 Jan 29;11(1):1155-1164
A robust TDP-43 knock-in mouse model of ALS.
Huang SL, Wu LS, Lee M, Chang CW, Cheng WC, Fang YS, Chen YR, Cheng PL, Shen CJ
Acta neuropathologica communications 2020 Jan 21;8(1):3
Acta neuropathologica communications 2020 Jan 21;8(1):3
The Preparation of Ginsenoside Rg5, Its Antitumor Activity against Breast Cancer Cells and Its Targeting of PI3K.
Liu Y, Fan D
Nutrients 2020 Jan 18;12(1)
Nutrients 2020 Jan 18;12(1)
Propofol facilitates migration and invasion of oral squamous cell carcinoma cells by upregulating SNAI1 expression.
Li C, Xia M, Wang H, Li W, Peng J, Jiang H
Life sciences 2020 Jan 15;241:117143
Life sciences 2020 Jan 15;241:117143
The potential of Diosgenin in treating psoriasis: Studies from HaCaT keratinocytes and imiquimod-induced murine model.
Wu S, Zhao M, Sun Y, Xie M, Le K, Xu M, Huang C
Life sciences 2020 Jan 15;241:117115
Life sciences 2020 Jan 15;241:117115
Icariin protects human nucleus pulposus cells from hydrogen peroxide-induced mitochondria-mediated apoptosis by activating nuclear factor erythroid 2-related factor 2.
Hua W, Li S, Luo R, Wu X, Zhang Y, Liao Z, Song Y, Wang K, Zhao K, Yang S, Yang C
Biochimica et biophysica acta. Molecular basis of disease 2020 Jan 1;1866(1):165575
Biochimica et biophysica acta. Molecular basis of disease 2020 Jan 1;1866(1):165575
FOXO3/TRIM22 axis abated the antitumor effect of gemcitabine in non-small cell lung cancer via autophagy induction.
Wang Y, Liang HX, Zhang CM, Zou M, Zou BB, Wei W, Hu W
Translational cancer research 2020 Feb;9(2):937-948
Translational cancer research 2020 Feb;9(2):937-948
Chronic toxicity of methamphetamine: Oxidative remodeling of pulmonary arteries.
Liang LY, Wang MM, Liu M, Zhao W, Wang X, Shi L, Zhu MJ, Zhao YL, Liu L, Maurya P, Wang Y
Toxicology in vitro : an international journal published in association with BIBRA 2020 Feb;62:104668
Toxicology in vitro : an international journal published in association with BIBRA 2020 Feb;62:104668
Prucalopride inhibits lung cancer cell proliferation, invasion, and migration through blocking of the PI3K/AKT/mTor signaling pathway.
Chen M, Zhu LL, Su JL, Li GL, Wang J, Zhang YN
Human & experimental toxicology 2020 Feb;39(2):173-181
Human & experimental toxicology 2020 Feb;39(2):173-181
A randomized phase 2 trial of apatinib vs observation as maintenance treatment following first-line induction chemotherapy in extensive- stage small cell lung cancer.
Luo H, Zhang L, Yang B, Feng Y, Xiong Y, Zhang S, Li X, Qian C, Dong W, Dai N
Investigational new drugs 2020 Feb;38(1):148-159
Investigational new drugs 2020 Feb;38(1):148-159
Berberine inhibits proliferation and migration of colorectal cancer cells by downregulation of GRP78.
Gong C, Hu X, Xu Y, Yang J, Zong L, Wang C, Zhu J, Li Z, Lu D
Anti-cancer drugs 2020 Feb;31(2):141-149
Anti-cancer drugs 2020 Feb;31(2):141-149
FGFRL1 affects chemoresistance of small-cell lung cancer by modulating the PI3K/Akt pathway via ENO1.
Chen R, Li D, Zheng M, Chen B, Wei T, Wang Y, Li M, Huang W, Tong Q, Wang Q, Zhu Y, Fang W, Guo L, Fang S
Journal of cellular and molecular medicine 2020 Feb;24(3):2123-2134
Journal of cellular and molecular medicine 2020 Feb;24(3):2123-2134
N-glycosylation of uterine endometrium determines its receptivity.
Yu M, Qin H, Wang H, Liu J, Liu S, Yan Q
Journal of cellular physiology 2020 Feb;235(2):1076-1089
Journal of cellular physiology 2020 Feb;235(2):1076-1089
Pizotifen inhibits the proliferation and invasion of gastric cancer cells.
Jiang Y, Wang W, Wu X, Shi J
Experimental and therapeutic medicine 2020 Feb;19(2):817-824
Experimental and therapeutic medicine 2020 Feb;19(2):817-824
Targeting of β-Catenin Reverses Radioresistance of Cervical Cancer with the PIK3CA-E545K Mutation.
Jiang W, Wu Y, He T, Zhu H, Ke G, Xiang L, Yang H
Molecular cancer therapeutics 2020 Feb;19(2):337-347
Molecular cancer therapeutics 2020 Feb;19(2):337-347
1,3-Dicaffeoylquinic acid targeting 14-3-3 tau suppresses human breast cancer cell proliferation and metastasis through IL6/JAK2/PI3K pathway.
Zhou Y, Fu X, Guan Y, Gong M, He K, Huang B
Biochemical pharmacology 2020 Feb;172:113752
Biochemical pharmacology 2020 Feb;172:113752
Transforming growth factor-β1-regulated Fas/FasL pathway activation suppresses nucleus pulposus cell apoptosis in an inflammatory environment.
Xie J, Li B, Yao B, Zhang P, Wang L, Lu H, Song X
Bioscience reports 2020 Feb 28;40(2)
Bioscience reports 2020 Feb 28;40(2)
Bruceine D induces lung cancer cell apoptosis and autophagy via the ROS/MAPK signaling pathway in vitro and in vivo.
Fan J, Ren D, Wang J, Liu X, Zhang H, Wu M, Yang G
Cell death & disease 2020 Feb 18;11(2):126
Cell death & disease 2020 Feb 18;11(2):126
Intravenously Infusing the Secretome of Adipose-Derived Mesenchymal Stem Cells Ameliorates Neuroinflammation and Neurological Functioning After Traumatic Brain Injury.
Xu C, Diao YF, Wang J, Liang J, Xu HH, Zhao ML, Zheng B, Luan Z, Wang JJ, Yang XP, Wei MG, Duan JH, Wang KQ, Chen C, Chen F, Ming D, Zhang S, Sun HT, Li XH
Stem cells and development 2020 Feb 15;29(4):222-234
Stem cells and development 2020 Feb 15;29(4):222-234
Microcystin-leucine-arginine induced neurotoxicity by initiating mitochondrial fission in hippocampal neurons.
Zhang C, Wang J, Zhu J, Chen Y, Han X
The Science of the total environment 2020 Feb 10;703:134702
The Science of the total environment 2020 Feb 10;703:134702
Epigenetic silencing of IGFBPL1 promotes esophageal cancer growth by activating PI3K-AKT signaling.
Liu Y, Zhang M, He T, Yang W, Wang L, Zhang L, Guo M
Clinical epigenetics 2020 Feb 10;12(1):22
Clinical epigenetics 2020 Feb 10;12(1):22
MiR-21 modulates the polarization of macrophages and increases the effects of M2 macrophages on promoting the chemoresistance of ovarian cancer.
An Y, Yang Q
Life sciences 2020 Feb 1;242:117162
Life sciences 2020 Feb 1;242:117162
Britanin Exhibits Potential Inhibitory Activity on Human Prostate Cancer Cell Lines Through PI3K/Akt/NF-κB Signaling Pathways.
Zeng Q, Zeng Y, Nie X, Guo Y, Zhan Y
Planta medica 2020 Dec;86(18):1401-1410
Planta medica 2020 Dec;86(18):1401-1410
Positive regulation of the CREB phosphorylation via JNK-dependent pathway prevents antimony-induced neuronal apoptosis in PC12 cell and mice brain.
Zhi Y, Lu C, Zhu G, Li Z, Zhu P, Liu Y, Shi W, Su L, Jiang J, Qu J, Zhao X
Neurotoxicology 2020 Dec;81:101-108
Neurotoxicology 2020 Dec;81:101-108
Ursolic acid derivative UA232 evokes apoptosis of lung cancer cells induced by endoplasmic reticulum stress.
Gou W, Luo N, Wei H, Wu H, Yu X, Duan Y, Bi C, Ning H, Hou W, Li Y
Pharmaceutical biology 2020 Dec;58(1):707-715
Pharmaceutical biology 2020 Dec;58(1):707-715
Protective effect of hydroxysafflor yellow A on dopaminergic neurons against 6-hydroxydopamine, activating anti-apoptotic and anti-neuroinflammatory pathways.
Yang X, Li Y, Chen L, Xu M, Wu J, Zhang P, Nel D, Sun B
Pharmaceutical biology 2020 Dec;58(1):686-694
Pharmaceutical biology 2020 Dec;58(1):686-694
Anti-tumour activity of zinc ionophore pyrithione in human ovarian cancer cells through inhibition of proliferation and migration and promotion of lysosome-mitochondrial apoptosis.
Chen M, Ding Y, Ke Y, Zeng Y, Liu N, Zhong Y, Hua X, Li Z, Xiong Y, Wu C, Yu H
Artificial cells, nanomedicine, and biotechnology 2020 Dec;48(1):824-833
Artificial cells, nanomedicine, and biotechnology 2020 Dec;48(1):824-833
Synergistic antitumor activity of sorafenib and artesunate in hepatocellular carcinoma cells.
Yao X, Zhao CR, Yin H, Wang K, Gao JJ
Acta pharmacologica Sinica 2020 Dec;41(12):1609-1620
Acta pharmacologica Sinica 2020 Dec;41(12):1609-1620
Alpha-fetoprotein accelerates the progression of hepatocellular carcinoma by promoting Bcl-2 gene expression through an RA-RAR signalling pathway.
Zhang C, Zhang J, Wang J, Yan Y, Zhang C
Journal of cellular and molecular medicine 2020 Dec;24(23):13804-13812
Journal of cellular and molecular medicine 2020 Dec;24(23):13804-13812
Associations between Huwe1 and autophagy in rat cerebral neuron oxygen‑glucose deprivation and reperfusion injury.
He GQ, Chen Y, Liao HJ, Xu WM, Zhang W, He GL
Molecular medicine reports 2020 Dec;22(6):5083-5094
Molecular medicine reports 2020 Dec;22(6):5083-5094
Synchrotron FTIR microspectroscopy revealed apoptosis-induced biomolecular changes of cholangiocarcinoma cells treated with ursolic acid.
Maphanao P, Thanan R, Loilome W, Chio-Srichan S, Wongwattanakul M, Sakonsinsiri C
Biochimica et biophysica acta. General subjects 2020 Dec;1864(12):129708
Biochimica et biophysica acta. General subjects 2020 Dec;1864(12):129708
Microcystin-LR exposure results in aberrant spindles and induces apoptosis in porcine oocytes.
Shi F, Li W, Zhao H, He Y, Jiang Y, Ni J, Abbasi B, Rui R, Ju S
Theriogenology 2020 Dec;158:358-367
Theriogenology 2020 Dec;158:358-367
Silibinin ameliorats H(2)O(2)-induced cell apoptosis and oxidative stress response by activating Nrf2 signaling in trophoblast cells.
Guo H, Wang Y, Liu D
Acta histochemica 2020 Dec;122(8):151620
Acta histochemica 2020 Dec;122(8):151620
MicroRNA (MiR)-301a-3p regulates the proliferation of esophageal squamous cells via targeting PTEN.
Zhang N, Liu JF
Bioengineered 2020 Dec;11(1):972-983
Bioengineered 2020 Dec;11(1):972-983
Latcripin-7A, derivative of Lentinula edodes C(91-3), reduces migration and induces apoptosis, autophagy, and cell cycle arrest at G(1) phase in breast cancer cells.
Din SRU, Zhong M, Nisar MA, Saleem MZ, Hussain A, Khinsar KH, Alam S, Ayub G, Kanwal S, Li X, Zhang W, Wang X, Ning A, Cao J, Huang M
Applied microbiology and biotechnology 2020 Dec;104(23):10165-10179
Applied microbiology and biotechnology 2020 Dec;104(23):10165-10179
Ssc-miR-21-5p regulates endometrial epithelial cell proliferation, apoptosis and migration via the PDCD4/AKT pathway.
Hua R, Zhang X, Li W, Lian W, Liu Q, Gao D, Wang Y, Lei M
Journal of cell science 2020 Dec 9;133(23)
Journal of cell science 2020 Dec 9;133(23)
Silencing of lncRNA MIAT alleviates LPS-induced pneumonia via regulating miR-147a/NKAP/NF-κB axis.
Liu M, Li W, Song F, Zhang L, Sun X
Aging 2020 Dec 9;13(2):2506-2518
Aging 2020 Dec 9;13(2):2506-2518
Exogenous hydrogen sulfide inhibits apoptosis by regulating endoplasmic reticulum stress-autophagy axis and improves myocardial reconstruction after acute myocardial infarction.
Li Y, Liu M, Yi J, Song X, Zheng X, Liu D, Wang S, Chu C, Yang J
Acta biochimica et biophysica Sinica 2020 Dec 29;52(12):1325-1336
Acta biochimica et biophysica Sinica 2020 Dec 29;52(12):1325-1336
An SGLT2 inhibitor modulates SHH expression by activating AMPK to inhibit the migration and induce the apoptosis of cervical carcinoma cells.
Xie Z, Wang F, Lin L, Duan S, Liu X, Li X, Li T, Xue M, Cheng Y, Ren H, Zhu Y
Cancer letters 2020 Dec 28;495:200-210
Cancer letters 2020 Dec 28;495:200-210
Overexpression of Mucin 1 Suppresses the Therapeutical Efficacy of Disulfiram against Canine Mammary Tumor.
Zhao Y, Lin Z, Lin Z, Zhou C, Liu G, Lin J, Zhang D, Lin D
Animals : an open access journal from MDPI 2020 Dec 27;11(1)
Animals : an open access journal from MDPI 2020 Dec 27;11(1)
Transplanting Rac1-silenced bone marrow mesenchymal stem cells promote neurological function recovery in TBI mice.
Huang D, Siaw-Debrah F, Wang H, Ye S, Wang K, Wu K, Zhang Y, Wang H, Yao C, Chen J, Yan L, Zhang CL, Zhuge Q, Yang J
Aging 2020 Dec 19;13(2):2822-2850
Aging 2020 Dec 19;13(2):2822-2850
Curcumin protects rat hippocampal neurons against pseudorabies virus by regulating the BDNF/TrkB pathway.
Yang B, Luo G, Zhang C, Feng L, Luo X, Gan L
Scientific reports 2020 Dec 17;10(1):22204
Scientific reports 2020 Dec 17;10(1):22204
Serine-70 phosphorylated Bcl-2 prevents oxidative stress-induced DNA damage by modulating the mitochondrial redox metabolism.
Chong SJF, Iskandar K, Lai JXH, Qu J, Raman D, Valentin R, Herbaux C, Collins M, Low ICC, Loh T, Davids M, Pervaiz S
Nucleic acids research 2020 Dec 16;48(22):12727-12745
Nucleic acids research 2020 Dec 16;48(22):12727-12745
Exosome-mediated Hic-5 regulates proliferation and apoptosis of osteosarcoma via Wnt/β-catenin signal pathway.
Sha L, Ma D, Chen C
Aging 2020 Dec 13;12(23):23598-23608
Aging 2020 Dec 13;12(23):23598-23608
Combined toxic effects of CBNPs and Pb on rat alveolar macrophage apoptosis and autophagy flux.
Guan S, Tao S, Huang Y, Jin Y, Hu Y, Lu J
Ecotoxicology and environmental safety 2020 Dec 1;205:111062
Ecotoxicology and environmental safety 2020 Dec 1;205:111062
Polyphyllin I suppresses proliferation and promotes apoptosis of gastric cancer cell by inhibiting stat3 phosphorylation.
Han J, Kan J, Wang X, Yuan Q, Song X, Huang M, Wu H
Translational cancer research 2020 Aug;9(8):4715-4725
Translational cancer research 2020 Aug;9(8):4715-4725
Knockdown of interferon-induced transmembrane protein 1 inhibited proliferation, induced cell cycle arrest and apoptosis, and suppressed MAPK signaling pathway in pancreatic cancer cells.
Zhang L, Wang Z, Kong D, Zhao X, Chen X, Chai W
Bioscience, biotechnology, and biochemistry 2020 Aug;84(8):1603-1613
Bioscience, biotechnology, and biochemistry 2020 Aug;84(8):1603-1613
Norfloxacin induces apoptosis and necroptosis in human corneal epithelial cells.
Yang T, Fan TJ, Xu B
Toxicology in vitro : an international journal published in association with BIBRA 2020 Aug;66:104868
Toxicology in vitro : an international journal published in association with BIBRA 2020 Aug;66:104868
Blocking Parkin/PINK1-mediated mitophagy sensitizes hepatocellular carcinoma cells to sanguinarine-induced mitochondrial apoptosis.
Su Q, Wang J, Liu F, Zhang Y
Toxicology in vitro : an international journal published in association with BIBRA 2020 Aug;66:104840
Toxicology in vitro : an international journal published in association with BIBRA 2020 Aug;66:104840
Metabolomic profiling reveals similar cytotoxic effects and protective functions of quercetin during deoxynivalenol- and 15-acetyl deoxynivalenol-induced cell apoptosis.
Yang YX, Yu S, Jia BX, Liu N, Wu A
Toxicology in vitro : an international journal published in association with BIBRA 2020 Aug;66:104838
Toxicology in vitro : an international journal published in association with BIBRA 2020 Aug;66:104838
Nicotinamide N-methyltransferase decreases 5-fluorouracil sensitivity in human esophageal squamous cell carcinoma through metabolic reprogramming and promoting the Warburg effect.
Cui Y, Yang D, Wang W, Zhang L, Liu H, Ma S, Guo W, Yao M, Zhang K, Li W, Zhang Y, Guan F
Molecular carcinogenesis 2020 Aug;59(8):940-954
Molecular carcinogenesis 2020 Aug;59(8):940-954
WWP2 ameliorates acute kidney injury by mediating p53 ubiquitylation and degradation.
Che H, He W, Feng J, Dong W, Liu S, Chen T, Ge S, Zhou J, Liang C
Cell biochemistry and function 2020 Aug;38(6):695-701
Cell biochemistry and function 2020 Aug;38(6):695-701
Effects of PYRIN-containing Apaf1-like protein 1 on isoflurane-induced postoperative cognitive dysfunction in aged rats.
Zhang X, Fan X, Li F, Qiu J, Zhang Y
Molecular medicine reports 2020 Aug;22(2):1391-1399
Molecular medicine reports 2020 Aug;22(2):1391-1399
Prazosin inhibits the proliferation, migration and invasion, but promotes the apoptosis of U251 and U87 cells via the PI3K/AKT/mTOR signaling pathway.
Zhang J, Fan J
Experimental and therapeutic medicine 2020 Aug;20(2):1145-1152
Experimental and therapeutic medicine 2020 Aug;20(2):1145-1152
Midazolam contributes to neuroprotection against hypoxia/reoxygenation-induced brain injury in neonatal rats via regulation of EAAT2.
Tang Z, Yang F, Dong Y, Ma C, Sun S, Shan Y, Zhang Y, Liu H
Brain research bulletin 2020 Aug;161:136-146
Brain research bulletin 2020 Aug;161:136-146
Baohuoside-1 targeting mTOR inducing apoptsis to inhibit hepatocellular carcinoma proliferation, invasion and migration.
Guo Y, Zhu H, Weng M, Chen B, Wang C, Sun L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Aug;128:110366
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Aug;128:110366
Fraxetin inhibits the growth of colon adenocarcinoma cells via the Janus kinase 2/signal transducer and activator of transcription 3 signalling pathway.
Ren S, Xing Y, Wang C, Jiang F, Liu G, Li Z, Jiang T, Zhu Y, Piao D
The international journal of biochemistry & cell biology 2020 Aug;125:105777
The international journal of biochemistry & cell biology 2020 Aug;125:105777
Activation of the Hedgehog Pathway Promotes Recovery of Neurological Function After Traumatic Brain Injury by Protecting the Neurovascular Unit.
Wu J, He J, Tian X, Zhong J, Li H, Sun X
Translational stroke research 2020 Aug;11(4):720-733
Translational stroke research 2020 Aug;11(4):720-733
IL13Rα1 protects against rheumatoid arthritis by combating the apoptotic resistance of fibroblast-like synoviocytes.
Yang X, Guo Q, Feng T, Lu Q, Ge L, Pan J, Bi K, Qiao L, Tian L, Xie T, Yao C, Song G, Wang L
Arthritis research & therapy 2020 Aug 8;22(1):184
Arthritis research & therapy 2020 Aug 8;22(1):184
S100A8 transported by SEC23A inhibits metastatic colonization via autocrine activation of autophagy.
Sun Z, Zeng B, Liu D, Zhao Q, Wang J, Rosie Xing H
Cell death & disease 2020 Aug 6;11(8):650
Cell death & disease 2020 Aug 6;11(8):650
A mitochondria-targeted anticancer nanoplatform with deep penetration for enhanced synergistic sonodynamic and starvation therapy.
Zhang R, Zhang L, Ran H, Li P, Huang J, Tan M, Yang Y, Wang Z
Biomaterials science 2020 Aug 21;8(16):4581-4594
Biomaterials science 2020 Aug 21;8(16):4581-4594
A Novel Pharmacological Approach to Enhance the Integrity and Accelerate Restitution of the Intestinal Epithelial Barrier.
Cao X, Sun L, Lechuga S, Naydenov NG, Feygin A, Ivanov AI
Inflammatory bowel diseases 2020 Aug 20;26(9):1340-1352
Inflammatory bowel diseases 2020 Aug 20;26(9):1340-1352
Upregulation of circ-0000745 in acute lymphoblastic leukemia enhanced cell proliferation by activating ERK pathway.
Liu X, Zhou C, Li Y, Deng Y, Lu W, Li J
Gene 2020 Aug 15;751:144726
Gene 2020 Aug 15;751:144726
Antagomirs targeting miR-142-5p attenuate pilocarpine-induced status epilepticus in mice.
Zhang H, Lian Y, Xie N, Cheng X, Chen C, Xu H, Zheng Y
Experimental cell research 2020 Aug 15;393(2):112089
Experimental cell research 2020 Aug 15;393(2):112089
Bcl2 inhibitor ABT737 reverses the Warburg effect via the Sirt3-HIF1α axis to promote oxidative stress-induced apoptosis in ovarian cancer cells.
Dong D, Dong Y, Fu J, Lu S, Yuan C, Xia M, Sun L
Life sciences 2020 Aug 15;255:117846
Life sciences 2020 Aug 15;255:117846
Protective function of exosomes from adipose tissue-derived mesenchymal stem cells in acute kidney injury through SIRT1 pathway.
Gao F, Zuo B, Wang Y, Li S, Yang J, Sun D
Life sciences 2020 Aug 15;255:117719
Life sciences 2020 Aug 15;255:117719
Inhibiting pannexin-1 alleviates sepsis-induced acute kidney injury via decreasing NLRP3 inflammasome activation and cell apoptosis.
Huang G, Bao J, Shao X, Zhou W, Wu B, Ni Z, Wang L
Life sciences 2020 Aug 1;254:117791
Life sciences 2020 Aug 1;254:117791
Therapeutic mechanism of human neural stem cell-derived extracellular vesicles against hypoxia-reperfusion injury in vitro.
Liu Q, Tan Y, Qu T, Zhang J, Duan X, Xu H, Mu Y, Ma H, Wang F
Life sciences 2020 Aug 1;254:117772
Life sciences 2020 Aug 1;254:117772
Oxymatrine protects neonatal rat against hypoxic-ischemic brain damage via PI3K/Akt/GSK3β pathway.
Liu Y, Wang H, Liu N, Du J, Lan X, Qi X, Zhuang C, Sun T, Li Y, Yu J
Life sciences 2020 Aug 1;254:116444
Life sciences 2020 Aug 1;254:116444
MicroRNA-760 inhibits cell viability and migration through down-regulating BST2 in gastric cancer.
Liu W, Li Y, Feng S, Guan Y, Cao Y
Journal of biochemistry 2020 Aug 1;168(2):159-170
Journal of biochemistry 2020 Aug 1;168(2):159-170
RETRACTED: MicroRNA-208-5p regulates myocardial injury of sepsis mice via targeting SOCS2-mediated NF-κB/HIF-1α pathway.
Ouyang H, Tan Y, Li Q, Xia F, Xiao X, Zheng S, Lu J, Zhong J, Hu Y
International immunopharmacology 2020 Apr;81:106204
International immunopharmacology 2020 Apr;81:106204
Hydrogen sulfide inhibits cigarette smoke-induced inflammation and injury in alveolar epithelial cells by suppressing PHD2/HIF-1α/MAPK signaling pathway.
Guan R, Wang J, Li D, Li Z, Liu H, Ding M, Cai Z, Liang X, Yang Q, Long Z, Chen L, Liu W, Sun D, Yao H, Lu W
International immunopharmacology 2020 Apr;81:105979
International immunopharmacology 2020 Apr;81:105979
MicroRNA-378-3p/5p represses proliferation and induces apoptosis of oral squamous carcinoma cells via targeting KLK4.
Cui Z, Bao X, Liu Q, Li Q, Huang L, Wang H, Jiao K
Clinical and experimental pharmacology & physiology 2020 Apr;47(4):713-724
Clinical and experimental pharmacology & physiology 2020 Apr;47(4):713-724
CCN5 inhibits proliferation and promotes apoptosis of oral squamous cell carcinoma cells.
Sun S, Cui Z, Yan T, Wu J, Liu Z
Cell biology international 2020 Apr;44(4):998-1008
Cell biology international 2020 Apr;44(4):998-1008
Identification of a 3,3-difluorinated tetrahydropyridinol compound as a novel antitumor agent for hepatocellular carcinoma acting via cell cycle arrest through disturbing CDK7-mediated phosphorylation of Cdc2.
Bi W, Xiao JC, Liu RJ, Zhou LY, Zhang S, Yang M, Zhang PF
Investigational new drugs 2020 Apr;38(2):287-298
Investigational new drugs 2020 Apr;38(2):287-298
MTH1 Inhibitor TH287 Suppresses Gastric Cancer Development Through the Regulation of PI3K/AKT Signaling.
Zhan D, Zhang X, Li J, Ding X, Cui Y, Jia J
Cancer biotherapy & radiopharmaceuticals 2020 Apr;35(3):223-232
Cancer biotherapy & radiopharmaceuticals 2020 Apr;35(3):223-232
Organic anion transporters and PI3K-AKT-mTOR pathway mediate the synergistic anticancer effect of pemetrexed and rhein.
Bu T, Wang C, Jin H, Meng Q, Huo X, Sun H, Sun P, Wu J, Ma X, Liu Z, Liu K
Journal of cellular physiology 2020 Apr;235(4):3309-3319
Journal of cellular physiology 2020 Apr;235(4):3309-3319
Estradiol-17β regulates proliferation and apoptosis of sheep endometrial epithelial cells by regulating the relative abundance of YAP1.
An SY, Gao XX, Wang ZB, Liang YX, Wang ST, Xiao SH, Xia JT, You PH, Wang F, Zhang GM
Animal reproduction science 2020 Apr;215:106328
Animal reproduction science 2020 Apr;215:106328
Prazosin inhibits the proliferation and survival of acute myeloid leukaemia cells through down-regulating TNS1.
Sun X, Yang S, Song W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Apr;124:109731
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Apr;124:109731
MiR-664 Protects Against UVB Radiation-Induced HaCaT Cell Damage via Downregulating ARMC8.
Zhang C, Xie X, Yuan Y, Wang Y, Zhou M, Li X, Zhen P
Dose-response : a publication of International Hormesis Society 2020 Apr-Jun;18(2):1559325820929234
Dose-response : a publication of International Hormesis Society 2020 Apr-Jun;18(2):1559325820929234
Deferasirox protects against hydrogen peroxide-induced cell apoptosis by inhibiting ubiquitination and degradation of p21(WAF1/CIP1).
Miao J, Xu M, Kuang Y, Pan S, Hou J, Cao P, Duan X, Chang Y, Hasem H, Zhou N, Tan K, Fan Y
Biochemical and biophysical research communications 2020 Apr 9;524(3):736-743
Biochemical and biophysical research communications 2020 Apr 9;524(3):736-743
Resveratrol Attenuates Aflatoxin B(1)-Induced ROS Formation and Increase of m(6)A RNA Methylation.
Wu J, Gan Z, Zhuo R, Zhang L, Wang T, Zhong X
Animals : an open access journal from MDPI 2020 Apr 13;10(4)
Animals : an open access journal from MDPI 2020 Apr 13;10(4)
Doxorubicin-polyglycerol-nanodiamond conjugates disrupt STAT3/IL-6-mediated reciprocal activation loop between glioblastoma cells and astrocytes.
Chen Z, Yuan SJ, Li K, Zhang Q, Li TF, An HC, Xu HZ, Yue Y, Han M, Xu YH, Komatsu N, Zhao L, Chen X
Journal of controlled release : official journal of the Controlled Release Society 2020 Apr 10;320:469-483
Journal of controlled release : official journal of the Controlled Release Society 2020 Apr 10;320:469-483
MicroRNA-16 participates in the cell cycle alteration of HepG2 cells induced by MC-LR.
Feng Y, Chen X, Ding W, Ma J, Zhang B, Li X
Ecotoxicology and environmental safety 2020 Apr 1;192:110295
Ecotoxicology and environmental safety 2020 Apr 1;192:110295
MYCN-mediated regulation of the HES1 promoter enhances the chemoresistance of small-cell lung cancer by modulating apoptosis.
Tong Q, Ouyang S, Chen R, Huang J, Guo L
American journal of cancer research 2019;9(9):1938-1956
American journal of cancer research 2019;9(9):1938-1956
Oncogenic MSH6-CXCR4-TGFB1 Feedback Loop: A Novel Therapeutic Target of Photothermal Therapy in Glioblastoma Multiforme.
Chen Y, Liu P, Sun P, Jiang J, Zhu Y, Dong T, Cui Y, Tian Y, An T, Zhang J, Li Z, Yang X
Theranostics 2019;9(5):1453-1473
Theranostics 2019;9(5):1453-1473
A novel STAT3 inhibitor, HJC0152, exerts potent antitumor activity in glioblastoma.
Li Z, Zhu T, Xu Y, Wu C, Chen J, Ren Y, Kong L, Sun S, Guo W, Wang Y, Jing C, Dong J, Zhou J, Zhang L, Shen Q, Zhou X
American journal of cancer research 2019;9(4):699-713
American journal of cancer research 2019;9(4):699-713
Cinobufagin Promotes Cell Cycle Arrest and Apoptosis to Block Human Esophageal Squamous Cell Carcinoma Cells Growth via the p73 Signalling Pathway.
Deng X, Sheng J, Liu H, Wang N, Dai C, Wang Z, Zhang J, Zhao J, Dai E
Biological & pharmaceutical bulletin 2019;42(9):1500-1509
Biological & pharmaceutical bulletin 2019;42(9):1500-1509
Gefitinib-coated balloon inhibits the excessive hyperplasia of intima after vascular injuries through PI3K/AKT pathway.
Tang F, Liu M, Zeng O, Tan W, Long J, Liu S, Yang J, Chu C
Technology and health care : official journal of the European Society for Engineering and Medicine 2019;27(S1):331-343
Technology and health care : official journal of the European Society for Engineering and Medicine 2019;27(S1):331-343
LncRNA ZFAS1 promotes proliferation and migration and inhibits apoptosis in nasopharyngeal carcinoma via the PI3K/AKT pathway in vitro.
Wang X, Jin Q, Wang X, Chen W, Cai Z
Cancer biomarkers : section A of Disease markers 2019;26(2):171-182
Cancer biomarkers : section A of Disease markers 2019;26(2):171-182
Long noncoding RNA glutathione peroxidase 3-antisense inhibits lens epithelial cell apoptosis by upregulating glutathione peroxidase 3 expression in age-related cataract.
Tu Y, Li L, Qin B, Wu J, Cheng T, Kang L, Guan H
Molecular vision 2019;25:734-744
Molecular vision 2019;25:734-744
Down-regulation of miR-30b-5p protects cardiomyocytes against hypoxia-induced injury by targeting Aven.
Zhang L, Jia X
Cellular & molecular biology letters 2019;24:61
Cellular & molecular biology letters 2019;24:61
Therapeutic Effects of Human Urine-Derived Stem Cells in a Rat Model of Cisplatin-Induced Acute Kidney Injury In Vivo and In Vitro.
Sun B, Luo X, Yang C, Liu P, Yang Y, Dong X, Yang Z, Xu J, Zhang Y, Li L
Stem cells international 2019;2019:8035076
Stem cells international 2019;2019:8035076
Phosphocreatine Improves Cardiac Dysfunction by Normalizing Mitochondrial Respiratory Function through JAK2/STAT3 Signaling Pathway In Vivo and In Vitro.
Qaed E, Wang J, Almoiliqy M, Song Y, Liu W, Chu P, Alademi S, Alademi M, Li H, Alshwmi M, Al-Azab M, Ahsan A, Mahdi S, Han G, Niu M, Ali A, Shopit A, Wang H, Li X, Qaid A, Ma X, Li T, Peng J, Ma J, Zhang J, Tang Z
Oxidative medicine and cellular longevity 2019;2019:6521218
Oxidative medicine and cellular longevity 2019;2019:6521218
Methane-Rich Saline: A Potential Resuscitation Fluid for Hemorrhagic Shock.
Tong Y, Dong Y, Feng Y, Li Z, Jia Y, Zhang X, Qu K, Liu C, Zhang J
Oxidative medicine and cellular longevity 2019;2019:4929107
Oxidative medicine and cellular longevity 2019;2019:4929107
Oleic Acid Protects against Hepatic Ischemia and Reperfusion Injury in Mice by Inhibiting AKT/mTOR Pathways.
Guo J, Zhang T, Gu J, Cai K, Deng X, Chen K, Huang K, Wang G, Li H, Wang J
Oxidative medicine and cellular longevity 2019;2019:4842592
Oxidative medicine and cellular longevity 2019;2019:4842592
Carnosine Protects Mouse Podocytes from High Glucose Induced Apoptosis through PI3K/AKT and Nrf2 Pathways.
Zhao K, Li Y, Wang Z, Han N, Wang Y
BioMed research international 2019;2019:4348973
BioMed research international 2019;2019:4348973
Alleviation of Hepatic Ischemia Reperfusion Injury by Oleanolic Acid Pretreating via Reducing HMGB1 Release and Inhibiting Apoptosis and Autophagy.
Wang W, Wu L, Li J, Ji J, Chen K, Yu Q, Li S, Feng J, Liu T, Zhang J, Chen J, Zhou Y, Mao Y, Wang F, Dai W, Fan X, Guo C, Wu J
Mediators of inflammation 2019;2019:3240713
Mediators of inflammation 2019;2019:3240713
Nrf2/Keap1/ARE Signaling Mediated an Antioxidative Protection of Human Placental Mesenchymal Stem Cells of Fetal Origin in Alveolar Epithelial Cells.
Yan X, Fu X, Jia Y, Ma X, Tao J, Yang T, Ma H, Liang X, Liu X, Yang J, Wei J
Oxidative medicine and cellular longevity 2019;2019:2654910
Oxidative medicine and cellular longevity 2019;2019:2654910
Jiawei Foshou San Induces Apoptosis in Ectopic Endometrium Based on Systems Pharmacology, Molecular Docking, and Experimental Evidence.
Wei J, Zhao B, Zhang C, Shen B, Zhang Y, Li C, Chen Y
Evidence-based complementary and alternative medicine : eCAM 2019;2019:2360367
Evidence-based complementary and alternative medicine : eCAM 2019;2019:2360367
Overexpression of CD59 inhibits apoptosis of T-acute lymphoblastic leukemia via AKT/Notch1 signaling pathway.
Jia Y, Qi Y, Wang Y, Ma X, Xu Y, Wang J, Zhang X, Gao M, Cong B, Han S
Cancer cell international 2019;19:9
Cancer cell international 2019;19:9
Epigallocatechin-3-gallate inhibits the growth and increases the apoptosis of human thyroid carcinoma cells through suppression of EGFR/RAS/RAF/MEK/ERK signaling pathway.
Wu D, Liu Z, Li J, Zhang Q, Zhong P, Teng T, Chen M, Xie Z, Ji A, Li Y
Cancer cell international 2019;19:43
Cancer cell international 2019;19:43
Degradation of long non-coding RNA-CIR decelerates proliferation, invasion and migration, but promotes apoptosis of osteosarcoma cells.
Liu S, Li J, Kang L, Tian Y, Xue Y
Cancer cell international 2019;19:349
Cancer cell international 2019;19:349
Sevoflurane inhibits the progression of ovarian cancer through down-regulating stanniocalcin 1 (STC1).
Zhang C, Wang B, Wang X, Sheng X, Cui Y
Cancer cell international 2019;19:339
Cancer cell international 2019;19:339
LncRNA-LET inhibits cell growth of clear cell renal cell carcinoma by regulating miR-373-3p.
Ye Z, Duan J, Wang L, Ji Y, Qiao B
Cancer cell international 2019;19:311
Cancer cell international 2019;19:311
PPAR δ inhibition protects against palmitic acid-LPS induced lipidosis and injury in cultured hepatocyte L02 cell.
Li Y, Wang C, Lu J, Huang K, Han Y, Chen J, Yang Y, Liu B
International journal of medical sciences 2019;16(12):1593-1603
International journal of medical sciences 2019;16(12):1593-1603
NFAT5 is Regulated by p53/miR-27a Signal Axis and Promotes Mouse Ovarian Granulosa Cells Proliferation.
Tao H, Xiong Q, Ji Z, Zhang F, Liu Y, Chen M
International journal of biological sciences 2019;15(2):287-297
International journal of biological sciences 2019;15(2):287-297
Muscle Injury Associated Elevated Oxidative Stress and Abnormal Myogenesis in Patients with Idiopathic Scoliosis.
Li J, Tang M, Yang G, Wang L, Gao Q, Zhang H
International journal of biological sciences 2019;15(12):2584-2595
International journal of biological sciences 2019;15(12):2584-2595
The ginsenoside Rk3 exerts anti-esophageal cancer activity in vitro and in vivo by mediating apoptosis and autophagy through regulation of the PI3K/Akt/mTOR pathway.
Liu H, Zhao J, Fu R, Zhu C, Fan D
PloS one 2019;14(5):e0216759
PloS one 2019;14(5):e0216759
Celecoxib enhances the sensitivity of non-small-cell lung cancer cells to radiation-induced apoptosis through downregulation of the Akt/mTOR signaling pathway and COX-2 expression.
Zhang P, He D, Song E, Jiang M, Song Y
PloS one 2019;14(10):e0223760
PloS one 2019;14(10):e0223760
Multi-Walled Carbon Nanotubes (MWCNTs) Activate Apoptotic Pathway Through ER Stress: Does Surface Chemistry Matter?
Sun Y, Gong J, Cao Y
International journal of nanomedicine 2019;14:9285-9294
International journal of nanomedicine 2019;14:9285-9294
Synergism of cisplatin-oleanolic acid co-loaded calcium carbonate nanoparticles on hepatocellular carcinoma cells for enhanced apoptosis and reduced hepatotoxicity.
Khan MW, Zhao P, Khan A, Raza F, Raza SM, Sarfraz M, Chen Y, Li M, Yang T, Ma X, Xiang G
International journal of nanomedicine 2019;14:3753-3771
International journal of nanomedicine 2019;14:3753-3771
Catalpol prevents denervated muscular atrophy related to the inhibition of autophagy and reduces BAX/BCL2 ratio via mTOR pathway.
Wang Y, Shao Y, Gao Y, Wan G, Wan D, Zhu H, Qiu Y, Ye X
Drug design, development and therapy 2019;13:243-253
Drug design, development and therapy 2019;13:243-253
Gatifloxacin inducing apoptosis of stromal fibroblasts through cross-talk between caspase-dependent extrinsic and intrinsic pathways.
Xu B, Sui YL, Fan TJ
International journal of ophthalmology 2019;12(10):1524-1530
International journal of ophthalmology 2019;12(10):1524-1530
TNIP1 Inhibits Proliferation And Promotes Apoptosis In Clear Cell Renal Carcinoma Through Targeting C/Ebpβ.
Yang Y, Fan J, Han S, Li E
OncoTargets and therapy 2019;12:9861-9871
OncoTargets and therapy 2019;12:9861-9871
RGS4 Regulates Proliferation And Apoptosis Of NSCLC Cells Via microRNA-16 And Brain-Derived Neurotrophic Factor.
He Z, Yu L, Luo S, Li Q, Huang S, An Y
OncoTargets and therapy 2019;12:8701-8714
OncoTargets and therapy 2019;12:8701-8714
Long noncoding RNA UBE2R2-AS1 promotes glioma cell apoptosis via targeting the miR-877-3p/TLR4 axis.
Xu W, Hu GQ, Da Costa C, Tang JH, Li QR, Du L, Pan YW, Lv SQ
OncoTargets and therapy 2019;12:3467-3480
OncoTargets and therapy 2019;12:3467-3480
Effects of Vitamin K3 Combined with UVB on the Proliferation and Apoptosis of Cutaneous Squamous Cell Carcinoma A431 Cells.
Shi S, Zheng G, Yang C, Chen X, Yan Q, Jiang F, Jiang X, Xin Y, Jiang G
OncoTargets and therapy 2019;12:11715-11727
OncoTargets and therapy 2019;12:11715-11727
miR-7 Reverses Breast Cancer Resistance To Chemotherapy By Targeting MRP1 And BCL2.
Hong T, Ding J, Li W
OncoTargets and therapy 2019;12:11097-11105
OncoTargets and therapy 2019;12:11097-11105
DHT deteriorates the progression of monocrotaline-induced pulmonary arterial hypertension: effects of endogenous and exogenous androgen.
Wen J, Wang J, Tang X, Deng S, Dai J, Li X, Cai W
American journal of translational research 2019;11(9):5752-5763
American journal of translational research 2019;11(9):5752-5763
Hypoxia induces HT-22 neuronal cell death via Orai1/CDK5 pathway-mediated Tau hyperphosphorylation.
Fang B, Zhao Q, Ling W, Zhang Y, Ou M
American journal of translational research 2019;11(12):7591-7603
American journal of translational research 2019;11(12):7591-7603
Silencing of lncRNA HOXA11-AS inhibits cell migration, invasion, proliferation, and promotes apoptosis in human glioma cells via upregulating microRNA-125a: in vitro and in vivo studies.
Jiang J, Wang X, Gao G, Liu X, Chang H, Xiong R, Lu J, Sun Z
American journal of translational research 2019;11(10):6382-6392
American journal of translational research 2019;11(10):6382-6392
TMEFF1 overexpression and its mechanism for tumor promotion in ovarian cancer.
Nie X, Liu C, Guo Q, Zheng MJ, Gao LL, Li X, Liu DW, Zhu LC, Liu JJ, Lin B
Cancer management and research 2019;11:839-855
Cancer management and research 2019;11:839-855
BHLHE41 promotes U87 and U251 cell proliferation via ERK/cyclinD1 signaling pathway.
Wang C, Zhao N, Zheng Q, Zhang D, Liu Y
Cancer management and research 2019;11:7657-7672
Cancer management and research 2019;11:7657-7672
siPRDX2-elevated DNM3 inhibits the proliferation and metastasis of colon cancer cells via AKT signaling pathway.
Ma Y, Guan L, Han Y, Zhou Y, Li X, Liu Y, Zhang X, Zhang W, Li X, Wang S, Lu W
Cancer management and research 2019;11:5799-5811
Cancer management and research 2019;11:5799-5811
UNBS5162 and amonafide inhibits tumor progression in human melanoma by the AKT/mTOR pathway.
Ye Y, Huang S, Wu Y
Cancer management and research 2019;11:2339-2348
Cancer management and research 2019;11:2339-2348
Baohuoside I Inhibits the Proliferation of Pancreatic Cancer Cells via mTOR/S6K1-Caspases/Bcl2/Bax Apoptotic Signaling.
Ni F, Tang H, Wang C, Zhang H, Zheng C, Zhang N, Chen B, Sun L
Cancer management and research 2019;11:10609-10621
Cancer management and research 2019;11:10609-10621
Peptide V3 Inhibits the Growth of Human Hepatocellular Carcinoma by Inhibiting the Ras/Raf/MEK/ERK Signaling Pathway.
Wu D, Li M, Gao Y, Tian W, Li J, Zhang Q, Liu Z, Zheng M, Wang H, Wang J, Teng T, Zhang L, Ji X, Xie Z, Ji A, Li Y
Journal of Cancer 2019;10(7):1693-1706
Journal of Cancer 2019;10(7):1693-1706
Lyn Kinase Promotes the Proliferation of Malignant Melanoma Cells through Inhibition of Apoptosis and Autophagy via the PI3K/Akt Signaling Pathway.
Zhang Q, Meng X, Qin G, Xue X, Dang N
Journal of Cancer 2019;10(5):1197-1208
Journal of Cancer 2019;10(5):1197-1208
Methylation of SLFN11 promotes gastric cancer growth and increases gastric cancer cell resistance to cisplatin.
Peng Y, Wang L, Wu L, Zhang L, Nie G, Guo M
Journal of Cancer 2019;10(24):6124-6134
Journal of Cancer 2019;10(24):6124-6134
Lin28b is involved in curcumin-reversed paclitaxel chemoresistance and associated with poor prognosis in hepatocellular carcinoma.
Tian N, Shangguan W, Zhou Z, Yao Y, Fan C, Cai L
Journal of Cancer 2019;10(24):6074-6087
Journal of Cancer 2019;10(24):6074-6087
A Novel Resveratrol-Arsenic Trioxide Combination Treatment Synergistically Induces Apoptosis of Adriamycin-Selected Drug-Resistant Leukemia K562 Cells.
Chen J, Tian B, Zhou C, Sun J, Lin L, Jin S, Liu Q, Fu S, Liu L, Liu H, Zhang Z, Li C, Wei H
Journal of Cancer 2019;10(22):5483-5493
Journal of Cancer 2019;10(22):5483-5493
SIRT5 Promotes Hepatocellular Carcinoma Progression by Regulating Mitochondrial Apoptosis.
Zhang R, Wang C, Tian Y, Yao Y, Mao J, Wang H, Li Z, Xu Y, Ye M, Wang L
Journal of Cancer 2019;10(16):3871-3882
Journal of Cancer 2019;10(16):3871-3882
PINK1/Parkin-Mediated Mitophagy Regulation by Reactive Oxygen Species Alleviates Rocaglamide A-Induced Apoptosis in Pancreatic Cancer Cells.
Zhao C, He R, Shen M, Zhu F, Wang M, Liu Y, Chen H, Li X, Qin R
Frontiers in pharmacology 2019;10:968
Frontiers in pharmacology 2019;10:968
Resveratrol Protects Against Post-Contrast Acute Kidney Injury in Rabbits With Diabetic Nephropathy.
Wang Y, Wang B, Qi X, Zhang X, Ren K
Frontiers in pharmacology 2019;10:833
Frontiers in pharmacology 2019;10:833
Diosbulbin B-Induced Mitochondria-Dependent Apoptosis in L-02 Hepatocytes is Regulated by Reactive Oxygen Species-Mediated Autophagy.
Ye J, Xue M, Liu Y, Zhu S, Li Y, Liu X, Cai D, Rui J, Zhang L
Frontiers in pharmacology 2019;10:676
Frontiers in pharmacology 2019;10:676
The Anti-proliferative Activity of GnRH Through Downregulation of the Akt/ERK Pathways in Pancreatic Cancer.
Suo L, Chang X, Xu N, Ji H
Frontiers in endocrinology 2019;10:370
Frontiers in endocrinology 2019;10:370
Prazosin inhibits the growth and mobility of osteosarcoma cells.
An M, Ma WH, Jia HW, Li YW, Feng JJ, Meng J, Qi H, Liu J
Translational cancer research 2019 Sep;8(5):1997-2004
Translational cancer research 2019 Sep;8(5):1997-2004
Knockdown of SP1/Syncytin1 axis inhibits the proliferation and metastasis through the AKT and ERK1/2 signaling pathways in non-small cell lung cancer.
Li X, Fu Y, Xia X, Zhang X, Xiao K, Zhuang X, Zhang Y
Cancer medicine 2019 Sep;8(12):5750-5759
Cancer medicine 2019 Sep;8(12):5750-5759
miR-671-5p Inhibits Tumor Proliferation by Blocking Cell Cycle in Osteosarcoma.
Xin C, Lu S, Li Y, Zhang Y, Tian J, Zhang S, Yang S, Gao T, Xu J
DNA and cell biology 2019 Sep;38(9):996-1004
DNA and cell biology 2019 Sep;38(9):996-1004
PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation.
Lin Q, Li S, Jiang N, Shao X, Zhang M, Jin H, Zhang Z, Shen J, Zhou Y, Zhou W, Gu L, Lu R, Ni Z
Redox biology 2019 Sep;26:101254
Redox biology 2019 Sep;26:101254
Bavachinin exhibits antitumor activity against non‑small cell lung cancer by targeting PPARγ.
Ge LN, Yan L, Li C, Cheng K
Molecular medicine reports 2019 Sep;20(3):2805-2811
Molecular medicine reports 2019 Sep;20(3):2805-2811
Sonic hedgehog pathway mediates genistein inhibition of renal cancer stem cells.
Li E, Zhang T, Sun X, Li Y, Geng H, Yu D, Zhong C
Oncology letters 2019 Sep;18(3):3081-3091
Oncology letters 2019 Sep;18(3):3081-3091
Association between CIRP expression and hypoxic-ischemic brain injury in neonatal rats.
Chen L, Tian Q, Wang W
Experimental and therapeutic medicine 2019 Sep;18(3):1515-1520
Experimental and therapeutic medicine 2019 Sep;18(3):1515-1520
Functional daidzein enhances the anticancer effect of topotecan and reverses BCRP-mediated drug resistance in breast cancer.
Guo J, Wang Q, Zhang Y, Sun W, Zhang S, Li Y, Wang J, Bao Y
Pharmacological research 2019 Sep;147:104387
Pharmacological research 2019 Sep;147:104387
HOXA11-AS regulates JAK-STAT pathway by miR-15a-3p/STAT3 axis to promote the growth and metastasis in liver cancer.
Wang S, Zhang S, He Y, Huang X, Hui Y, Tang Y
Journal of cellular biochemistry 2019 Sep;120(9):15941-15951
Journal of cellular biochemistry 2019 Sep;120(9):15941-15951
The oncogenic role of CB2 in the progression of non-small-cell lung cancer.
Xu S, Ma H, Bo Y, Shao M
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Sep;117:109080
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Sep;117:109080
Long non-coding RNA linc00645 promotes TGF-β-induced epithelial-mesenchymal transition by regulating miR-205-3p-ZEB1 axis in glioma.
Li C, Zheng H, Hou W, Bao H, Xiong J, Che W, Gu Y, Sun H, Liang P
Cell death & disease 2019 Sep 26;10(10):717
Cell death & disease 2019 Sep 26;10(10):717
Targeting the IL-1β/IL-1Ra pathways for the aggregation of human islet amyloid polypeptide in an ex vivo organ culture system of the intervertebral disc.
Wu X, Liao Z, Wang K, Hua W, Liu X, Song Y, Zhang Y, Yang S, Yang C
Experimental & molecular medicine 2019 Sep 25;51(9):1-16
Experimental & molecular medicine 2019 Sep 25;51(9):1-16
miR-375-3p suppresses tumorigenesis and partially reverses chemoresistance by targeting YAP1 and SP1 in colorectal cancer cells.
Xu X, Chen X, Xu M, Liu X, Pan B, Qin J, Xu T, Zeng K, Pan Y, He B, Sun H, Sun L, Wang S
Aging 2019 Sep 22;11(18):7357-7385
Aging 2019 Sep 22;11(18):7357-7385
αB-crystallin (CRYAB) regulates the proliferation, apoptosis, synthesis and degradation of extracellular matrix of chondrocytes in osteoarthritis.
Bao Q, Yang D, Hong F, Yang J, Li L, Jin Y, Ma C
Experimental cell research 2019 Sep 15;382(2):111459
Experimental cell research 2019 Sep 15;382(2):111459
Cypermethrin exposure reduces the ovarian reserve by causing mitochondrial dysfunction in granulosa cells.
Wang H, He Y, Cheng D, Pu D, Tan R, Gao L, Cui Y, Wu J
Toxicology and applied pharmacology 2019 Sep 15;379:114693
Toxicology and applied pharmacology 2019 Sep 15;379:114693
Corticosterone Excess-Mediated Mitochondrial Damage Induces Hippocampal Neuronal Autophagy in Mice Following Cold Exposure.
Xu B, Lang L, Li S, Yuan J, Wang J, Yang H, Lian S
Animals : an open access journal from MDPI 2019 Sep 14;9(9)
Animals : an open access journal from MDPI 2019 Sep 14;9(9)
Knockdown of METTL14 inhibits the growth and invasion of cervical cancer.
Geng F, Fan MJ, Li J, Liang SM, Li CY, Li N
Translational cancer research 2019 Oct;8(6):2307-2315
Translational cancer research 2019 Oct;8(6):2307-2315
Bromodomain inhibitor jq1 induces cell cycle arrest and apoptosis of glioma stem cells through the VEGF/PI3K/AKT signaling pathway.
Wen N, Guo B, Zheng H, Xu L, Liang H, Wang Q, Wang D, Chen X, Zhang S, Li Y, Zhang L
International journal of oncology 2019 Oct;55(4):879-895
International journal of oncology 2019 Oct;55(4):879-895
Paip1 Indicated Poor Prognosis in Cervical Cancer and Promoted Cervical Carcinogenesis.
Li N, Piao J, Wang X, Kim KY, Bae JY, Ren X, Lin Z
Cancer research and treatment 2019 Oct;51(4):1653-1665
Cancer research and treatment 2019 Oct;51(4):1653-1665
The protective effect of Cordycepin on diabetic nephropathy through autophagy induction in vivo and in vitro.
Cao T, Xu R, Xu Y, Liu Y, Qi D, Wan Q
International urology and nephrology 2019 Oct;51(10):1883-1892
International urology and nephrology 2019 Oct;51(10):1883-1892
Babao Dan induces gastric cancer cell apoptosis via regulating MAPK and NF-κB signaling pathways.
Shang H, Cao Z, Zhao J, Guan J, Liu J, Peng J, Chen Y, Joseph Sferra T, Sankararaman S, Lin J
The Journal of international medical research 2019 Oct;47(10):5106-5119
The Journal of international medical research 2019 Oct;47(10):5106-5119
Downregulation of nicotinamide N-methyltransferase inhibits migration and epithelial-mesenchymal transition of esophageal squamous cell carcinoma via Wnt/β-catenin pathway.
Cui Y, Zhang L, Wang W, Ma S, Liu H, Zang X, Zhang Y, Guan F
Molecular and cellular biochemistry 2019 Oct;460(1-2):93-103
Molecular and cellular biochemistry 2019 Oct;460(1-2):93-103
HMQ‑T‑F2 suppresses migration of the human cervical cancer HeLa cells by reversing EMT via the PI3K/Akt signaling pathway.
Dai B, Yu R, Fan M, Yang T, Wang B, Zhang Y
Oncology reports 2019 Oct;42(4):1451-1458
Oncology reports 2019 Oct;42(4):1451-1458
Fibrin matrix containing high-dose calcitriol promotes the apoptosis of gastric cancer cells by sustainably releasing calcitrol and D-dimer.
Hu P, Fang D, Shen L, Zhou H, Shao R, Chen M, Yao C, Shi Y, Chen Q
Journal of biomaterials applications 2019 Oct;34(4):509-522
Journal of biomaterials applications 2019 Oct;34(4):509-522
Autophagy protects HUVECs against ER stress-mediated apoptosis under simulated microgravity.
Li CF, Pan YK, Gao Y, Shi F, Wang YC, Sun XQ
Apoptosis : an international journal on programmed cell death 2019 Oct;24(9-10):812-825
Apoptosis : an international journal on programmed cell death 2019 Oct;24(9-10):812-825
LncRNA ADPGK-AS1 regulated cell proliferation, invasion, migration and apoptosis via targeting miR-542-3p in osteosarcoma.
Luo XF, Wu XJ, Wei X, Wang AG, Wang SH, Wang JL
European review for medical and pharmacological sciences 2019 Oct;23(20):8751-8760
European review for medical and pharmacological sciences 2019 Oct;23(20):8751-8760
Cisplatin decreases cyclin D2 expression via upregulating miR‑93 to inhibit lung adenocarcinoma cell growth.
Xie N, Liu YR, Li YM, Yang YN, Pan L, Wei YB, Wang PY, Li YJ, Xie SY
Molecular medicine reports 2019 Oct;20(4):3355-3362
Molecular medicine reports 2019 Oct;20(4):3355-3362
Cleavage and polyadenylation specific factor 4 promotes colon cancer progression by transcriptionally activating hTERT.
Yang Q, Fan W, Zheng Z, Lin S, Liu C, Wang R, Li W, Zuo Y, Sun Y, Hu S, Chen M, Guo P, Pan J, Tian C, Zhu T, Diao C, Hao J, Yu W, Li L, Li Y, Guo W, Deng W, Wu X
Biochimica et biophysica acta. Molecular cell research 2019 Oct;1866(10):1533-1543
Biochimica et biophysica acta. Molecular cell research 2019 Oct;1866(10):1533-1543
Downregulation of XBP1 decreases serous ovarian cancer cell viability and enhances sensitivity to oxidative stress by increasing intracellular ROS levels.
Zhang GH, Kai JY, Chen MM, Ma Q, Zhong AL, Xie SH, Zheng H, Wang YC, Tong Y, Tian Y, Lu RQ, Guo L
Oncology letters 2019 Oct;18(4):4194-4202
Oncology letters 2019 Oct;18(4):4194-4202
NKAP functions as an oncogene in Ewing sarcoma cells partly through the AKT signaling pathway.
Li F, Wu JT, Wang PF, Qu LZ
Experimental and therapeutic medicine 2019 Oct;18(4):3037-3045
Experimental and therapeutic medicine 2019 Oct;18(4):3037-3045
Ginsenoside Rg5 induces G2/M phase arrest, apoptosis and autophagy via regulating ROS-mediated MAPK pathways against human gastric cancer.
Liu Y, Fan D
Biochemical pharmacology 2019 Oct;168:285-304
Biochemical pharmacology 2019 Oct;168:285-304
Disocin prevents postmenopausal atherosclerosis in ovariectomized LDLR-/- mice through a PGC-1α/ERα pathway leading to promotion of autophagy and inhibition of oxidative stress, inflammation and apoptosis.
Yang Q, Wang C, Jin Y, Ma X, Xie T, Wang J, Liu K, Sun H
Pharmacological research 2019 Oct;148:104414
Pharmacological research 2019 Oct;148:104414
Qingjie Fuzheng Granule attenuates 5-fluorouracil-induced intestinal mucosal damage.
Zhang L, Jin Y, Peng J, Chen W, Lisha L, Lin J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109223
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109223
Fractionated irradiation of right thorax induces abscopal damage on testes leading to decline in fertility.
Zhang J, Yao D, Song Y, Pan Y, Zhu L, Bai Y, Xu Y, Zhang J, Shao C
Scientific reports 2019 Oct 23;9(1):15221
Scientific reports 2019 Oct 23;9(1):15221
Induction of Chemerin on Autophagy and Apoptosis in Dairy Cow Mammary Epithelial Cells.
Hu B, Song W, Tang Y, Shi M, Li H, Yu D
Animals : an open access journal from MDPI 2019 Oct 21;9(10)
Animals : an open access journal from MDPI 2019 Oct 21;9(10)
Functional genetic variants of RUVBL1 predict overall survival of Chinese patients with epithelial ovarian cancer.
Li H, Tong X, Xu Y, Wang M, Dai H, Shi T, Sun M, Chen K, Cheng X, Wei Q
Carcinogenesis 2019 Oct 16;40(10):1209-1219
Carcinogenesis 2019 Oct 16;40(10):1209-1219
γ-Oryzanol alleviates acetaminophen-induced liver injury: roles of modulating AMPK/GSK3β/Nrf2 and NF-κB signaling pathways.
Shu G, Qiu Y, Hao J, Fu Q, Deng X
Food & function 2019 Oct 16;10(10):6858-6872
Food & function 2019 Oct 16;10(10):6858-6872
Oxidation Stress-Mediated MAPK Signaling Pathway Activation Induces Neuronal Loss in the CA1 and CA3 Regions of the Hippocampus of Mice Following Chronic Cold Exposure.
Xu B, Lang LM, Lian S, Guo JR, Wang JF, Yang HM, Li SZ
Brain sciences 2019 Oct 12;9(10)
Brain sciences 2019 Oct 12;9(10)
Quetiapine induces myocardial necroptotic cell death through bidirectional regulation of cannabinoid receptors.
Li X, Peng Z, Zhou Y, Wang J, Lin X, Dong X, Liu X, Jiang J, Jiang Y, Li L
Toxicology letters 2019 Oct 1;313:77-90
Toxicology letters 2019 Oct 1;313:77-90
Enhancing autophagy by down-regulating GSK-3β alleviates cisplatin-induced ototoxicity in vivo and in vitro.
Liu T, Zong S, Luo P, Qu Y, Wen Y, Du P, Xiao H
Toxicology letters 2019 Oct 1;313:11-18
Toxicology letters 2019 Oct 1;313:11-18
Dysregulated expression of ACTN4 contributes to endothelial cell injury via the activation of the p38-MAPK/p53 apoptosis pathway in preeclampsia.
Zhao J, Peng W, Ran Y, Ge H, Zhang C, Zou H, Ding Y, Qi H
Journal of physiology and biochemistry 2019 Nov;75(4):475-487
Journal of physiology and biochemistry 2019 Nov;75(4):475-487
Piperine as a neuroprotective functional component in rats with cerebral ischemic injury.
Hua S, Liu J, Zhang Y, Li J, Zhang X, Dong L, Zhao Y, Fu X
Food science & nutrition 2019 Nov;7(11):3443-3451
Food science & nutrition 2019 Nov;7(11):3443-3451
Tannic acid synergistically enhances the anticancer efficacy of cisplatin on liver cancer cells through mitochondria‑mediated apoptosis.
Geng N, Zheng X, Wu M, Yang L, Li X, Chen J
Oncology reports 2019 Nov;42(5):2108-2116
Oncology reports 2019 Nov;42(5):2108-2116
Dehydrogenase/reductase SDR family member 2 silencing sensitizes an oxaliplatin‑resistant cell line to oxaliplatin by inhibiting excision repair cross‑complementing group 1 protein expression.
Li JM, Jiang GM, Zhao L, Yang F, Yuan WQ, Wang H, Luo YQ
Oncology reports 2019 Nov;42(5):1725-1734
Oncology reports 2019 Nov;42(5):1725-1734
Diabetes aggravates renal ischemia and reperfusion injury in rats by exacerbating oxidative stress, inflammation, and apoptosis.
Gong DJ, Wang L, Yang YY, Zhang JJ, Liu XH
Renal failure 2019 Nov;41(1):750-761
Renal failure 2019 Nov;41(1):750-761
Nonviral Delivery of GRIM-19 Gene Inhibits Tumor Growth with Reduced Local and Systemic Complications.
Xu Y, Wang X, Guo B, Wang D, Kalvakolanu DV, Chen X, Tang J, Zhang L, Yang Q
Human gene therapy 2019 Nov;30(11):1419-1430
Human gene therapy 2019 Nov;30(11):1419-1430
Impaired calcium homeostasis via advanced glycation end products promotes apoptosis through endoplasmic reticulum stress in human nucleus pulposus cells and exacerbates intervertebral disc degeneration in rats.
Luo R, Song Y, Liao Z, Yin H, Zhan S, Wang K, Li S, Li G, Ma L, Lu S, Zhang Y, Yang C
The FEBS journal 2019 Nov;286(21):4356-4373
The FEBS journal 2019 Nov;286(21):4356-4373
Iron dysregulation in vascular dementia: Focused on the AMPK/autophagy pathway.
Huo T, Jia Y, Yin C, Luo X, Zhao J, Wang Z, Lv P
Brain research bulletin 2019 Nov;153:305-313
Brain research bulletin 2019 Nov;153:305-313
Silencing Huwe1 reduces apoptosis of cortical neurons exposed to oxygen-glucose deprivation and reperfusion.
He GQ, Xu WM, Liao HJ, Jiang C, Li CQ, Zhang W
Neural regeneration research 2019 Nov;14(11):1977-1985
Neural regeneration research 2019 Nov;14(11):1977-1985
[Exogenous hydrogen sulfide improves erectile dysfunction by inhibiting apoptosis of corpus cavernosum smooth muscle cells in rats with cavernous nerve injury].
Zeng Q, He S, Zhong L, Wang L, Cheng F, Zhang H, Hui J, Wei A
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2019 Nov 30;39(11):1329-1336
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2019 Nov 30;39(11):1329-1336
Targetting an LncRNA P5848-ENO1 axis inhibits tumor growth in hepatocellular carcinoma.
Zhu X, Yu H, Li B, Quan J, Zeng Z, Li G, Liu J
Bioscience reports 2019 Nov 29;39(11)
Bioscience reports 2019 Nov 29;39(11)
Sulforaphane Mediates Glutathione Depletion via Polymeric Nanoparticles to Restore Cisplatin Chemosensitivity.
Xu Y, Han X, Li Y, Min H, Zhao X, Zhang Y, Qi Y, Shi J, Qi S, Bao Y, Nie G
ACS nano 2019 Nov 26;13(11):13445-13455
ACS nano 2019 Nov 26;13(11):13445-13455
Viral Nonstructural Protein 1 Induces Mitochondrion-Mediated Apoptosis in Mink Enteritis Virus Infection.
Lin P, Cheng Y, Song S, Qiu J, Yi L, Cao Z, Li J, Cheng S, Wang J
Journal of virology 2019 Nov 15;93(22)
Journal of virology 2019 Nov 15;93(22)
Cardioprotective effects of galectin-3 inhibition against ischemia/reperfusion injury.
Mo D, Tian W, Zhang HN, Feng YD, Sun Y, Quan W, Hao XW, Wang XY, Liu XX, Li C, Cao W, Liu WJ, Li XQ
European journal of pharmacology 2019 Nov 15;863:172701
European journal of pharmacology 2019 Nov 15;863:172701
A novel ALK inhibitor ZYY inhibits Karpas299 cell growth in vitro and in a mouse xenograft model and induces protective autophagy.
Shen J, Wang J, Du J, Wang L, Zhou X, Chang X, Li Z, Zhai X, Zuo D, Wu Y
Toxicology and applied pharmacology 2019 Nov 15;383:114781
Toxicology and applied pharmacology 2019 Nov 15;383:114781
Inhibition of Bcl-2 Synergistically Enhances the Antileukemic Activity of Midostaurin and Gilteritinib in Preclinical Models of FLT3-Mutated Acute Myeloid Leukemia.
Ma J, Zhao S, Qiao X, Knight T, Edwards H, Polin L, Kushner J, Dzinic SH, White K, Wang G, Zhao L, Lin H, Wang Y, Taub JW, Ge Y
Clinical cancer research : an official journal of the American Association for Cancer Research 2019 Nov 15;25(22):6815-6826
Clinical cancer research : an official journal of the American Association for Cancer Research 2019 Nov 15;25(22):6815-6826
The protective effect of oleanolic acid on NMDA-induced MLE-12 cells apoptosis and lung injury in mice by activating SIRT1 and reducing NF-κB acetylation.
Peng XP, Li XH, Li Y, Huang XT, Luo ZQ
International immunopharmacology 2019 May;70:520-529
International immunopharmacology 2019 May;70:520-529
Protective effects of levo-tetrahydropalmatine on hepatic ischemia/reperfusion injury are mediated by inhibition of the ERK/NF-κB pathway.
Yu Q, Wu L, Liu T, Li S, Feng J, Mao Y, Fan X, Guo C, Wu J
International immunopharmacology 2019 May;70:435-445
International immunopharmacology 2019 May;70:435-445
Activation of Nrf2 signaling by Icariin protects against 6-OHDA-induced neurotoxicity.
Zhu L, Li D, Chen C, Wang G, Shi J, Zhang F
Biotechnology and applied biochemistry 2019 May;66(3):465-471
Biotechnology and applied biochemistry 2019 May;66(3):465-471
Astragaloside IV attenuates myocardial ischemia/reperfusion injury in rats via inhibition of calcium-sensing receptor-mediated apoptotic signaling pathways.
Yin B, Hou XW, Lu ML
Acta pharmacologica Sinica 2019 May;40(5):599-607
Acta pharmacologica Sinica 2019 May;40(5):599-607
Dehydroepiandrosterone stimulates inflammation and impairs ovarian functions of polycystic ovary syndrome.
Li Y, Zheng Q, Sun D, Cui X, Chen S, Bulbul A, Liu S, Yan Q
Journal of cellular physiology 2019 May;234(5):7435-7447
Journal of cellular physiology 2019 May;234(5):7435-7447
1,7-Bis(4-hydroxyphenyl)-1,4-heptadien-3-one induces lung cancer cell apoptosis via the PI3K/Akt and ERK1/2 pathways.
Fan J, Wu M, Wang J, Ren D, Zhao J, Yang G
Journal of cellular physiology 2019 May;234(5):6336-6349
Journal of cellular physiology 2019 May;234(5):6336-6349
MARCH1 encourages tumour progression of hepatocellular carcinoma via regulation of PI3K-AKT-β-catenin pathways.
Xie L, Dai H, Li M, Yang W, Yu G, Wang X, Wang P, Liu W, Hu X, Zhao M
Journal of cellular and molecular medicine 2019 May;23(5):3386-3401
Journal of cellular and molecular medicine 2019 May;23(5):3386-3401
Establishment and characterization of a radiation-induced dermatitis rat model.
Sheng X, Zhou Y, Wang H, Shen Y, Liao Q, Rao Z, Deng F, Xie L, Yao C, Mao H, Liu Z, Peng M, Long Y, Zeng Y, Xue L, Gao N, Kong Y, Zhou X
Journal of cellular and molecular medicine 2019 May;23(5):3178-3189
Journal of cellular and molecular medicine 2019 May;23(5):3178-3189
SSRP1 promotes colorectal cancer progression and is negatively regulated by miR-28-5p.
Wu W, He K, Guo Q, Chen J, Zhang M, Huang K, Yang D, Wu L, Deng Y, Luo X, Yu H, Ding Q, Xiang G
Journal of cellular and molecular medicine 2019 May;23(5):3118-3129
Journal of cellular and molecular medicine 2019 May;23(5):3118-3129
Nano hydroxyapatite induces glioma cell apoptosis by suppressing NF-κB signaling pathway.
Guo G, Tian A, Lan X, Fu C, Yan Z, Wang C
Experimental and therapeutic medicine 2019 May;17(5):4080-4088
Experimental and therapeutic medicine 2019 May;17(5):4080-4088
Exogenous testosterone alleviates cardiac fibrosis and apoptosis via Gas6/Axl pathway in the senescent mice.
Chen FF, Song FQ, Chen YQ, Wang ZH, Li YH, Liu MH, Li Y, Song M, Zhang W, Zhao J, Zhong M
Experimental gerontology 2019 May;119:128-137
Experimental gerontology 2019 May;119:128-137
USP36 protects proximal tubule cells from ischemic injury by stabilizing c-Myc and SOD2.
Liu Q, Sheng W, Ma Y, Zhen J, Roy S, Alvira Jafar C, Xin W, Wan Q
Biochemical and biophysical research communications 2019 May 28;513(2):502-508
Biochemical and biophysical research communications 2019 May 28;513(2):502-508
LncRNA HMMR-AS1 promotes proliferation and metastasis of lung adenocarcinoma by regulating MiR-138/sirt6 axis.
Cai Y, Sheng Z, Chen Y, Wang J
Aging 2019 May 25;11(10):3041-3054
Aging 2019 May 25;11(10):3041-3054
CircRNA_014511 affects the radiosensitivity of bone marrow mesenchymal stem cells by binding to miR-29b-2-5p.
Wang Y, Zhang J, Li J, Gui R, Nie X, Huang R
Bosnian journal of basic medical sciences 2019 May 20;19(2):155-163
Bosnian journal of basic medical sciences 2019 May 20;19(2):155-163
Triptolide prevents proliferation and migration of Esophageal Squamous Cell Cancer via MAPK/ERK signaling pathway.
Yanchun M, Yi W, Lu W, Yu Q, Jian Y, Pengzhou K, Ting Y, Hongyi L, Fang W, Xiaolong C, Yongping C
European journal of pharmacology 2019 May 15;851:43-51
European journal of pharmacology 2019 May 15;851:43-51
Retinoic Acid-Related Orphan Receptor C Regulates Proliferation, Glycolysis, and Chemoresistance via the PD-L1/ITGB6/STAT3 Signaling Axis in Bladder Cancer.
Cao D, Qi Z, Pang Y, Li H, Xie H, Wu J, Huang Y, Zhu Y, Shen Y, Zhu Y, Dai B, Hu X, Ye D, Wang Z
Cancer research 2019 May 15;79(10):2604-2618
Cancer research 2019 May 15;79(10):2604-2618
Gambogic acid attenuates liver fibrosis by inhibiting the PI3K/AKT and MAPK signaling pathways via inhibiting HSP90.
Yu Z, Jv Y, Cai L, Tian X, Huo X, Wang C, Zhang B, Sun C, Ning J, Feng L, Zhang H, Ma X
Toxicology and applied pharmacology 2019 May 15;371:63-73
Toxicology and applied pharmacology 2019 May 15;371:63-73
Estrogen-related receptor-α mediates puromycin aminonucleoside-induced mesangial cell apoptosis and inflammatory injury.
Gong W, Song J, Chen X, Li S, Yu J, Xia W, Ding G, Zhang Y, Jia Z, Zhang A, Huang S
American journal of physiology. Renal physiology 2019 May 1;316(5):F906-F913
American journal of physiology. Renal physiology 2019 May 1;316(5):F906-F913
The preoperative neutrophil-to-lymphocyte ratio is not a marker of prostate cancer characteristics but is an independent predictor of biochemical recurrence in patients receiving radical prostatectomy.
Cao Z, Ji J, Zhang C, Wang F, Xu H, Yu Y, Sun Y
Cancer medicine 2019 Mar;8(3):1004-1012
Cancer medicine 2019 Mar;8(3):1004-1012
Hepatoprotective effects and structure-activity relationship of five flavonoids against lipopolysaccharide/d-galactosamine induced acute liver failure in mice.
He Y, Xia Z, Yu D, Wang J, Jin L, Huang D, Ye X, Li X, Zhang B
International immunopharmacology 2019 Mar;68:171-178
International immunopharmacology 2019 Mar;68:171-178
Combined inhibition of sonic Hedgehog signaling and histone deacetylase is an effective treatment for liver cancer.
Li J, Cai H, Li H, Liu Y, Wang Y, Shi Y, Sun Y, Song H, Wang D
Oncology reports 2019 Mar;41(3):1991-1997
Oncology reports 2019 Mar;41(3):1991-1997
Radiosensitization of esophageal carcinoma cells by knockdown of HMGB1 expression.
Zhang X, Yang X, Zhu S, Li Q, Zou N
Oncology reports 2019 Mar;41(3):1960-1970
Oncology reports 2019 Mar;41(3):1960-1970
XPC inhibition rescues cisplatin resistance via the Akt/mTOR signaling pathway in A549/DDP lung adenocarcinoma cells.
Teng X, Fan XF, Li Q, Liu S, Wu DY, Wang SY, Shi Y, Dong M
Oncology reports 2019 Mar;41(3):1875-1882
Oncology reports 2019 Mar;41(3):1875-1882
Betaine protects against heat exposure-induced oxidative stress and apoptosis in bovine mammary epithelial cells via regulation of ROS production.
Li C, Wang Y, Li L, Han Z, Mao S, Wang G
Cell stress & chaperones 2019 Mar;24(2):453-460
Cell stress & chaperones 2019 Mar;24(2):453-460
UNBS5162 inhibits SKOV3 ovarian cancer cell proliferation by regulating the PI3K/AKT signalling pathway.
Wang Q, Shi W
Oncology letters 2019 Mar;17(3):2976-2982
Oncology letters 2019 Mar;17(3):2976-2982
Nuciferine inhibits the progression of glioblastoma by suppressing the SOX2-AKT/STAT3-Slug signaling pathway.
Li Z, Chen Y, An T, Liu P, Zhu J, Yang H, Zhang W, Dong T, Jiang J, Zhang Y, Jiang M, Yang X
Journal of experimental & clinical cancer research : CR 2019 Mar 29;38(1):139
Journal of experimental & clinical cancer research : CR 2019 Mar 29;38(1):139
STAT1-mediated inhibition of FOXM1 enhances gemcitabine sensitivity in pancreatic cancer.
Liu C, Shi J, Li Q, Li Z, Lou C, Zhao Q, Zhu Y, Zhan F, Lian J, Wang B, Guan X, Fang L, Li Z, Wang Y, Zhou B, Yao Y, Zhang Y
Clinical science (London, England : 1979) 2019 Mar 15;133(5):645-663
Clinical science (London, England : 1979) 2019 Mar 15;133(5):645-663
Downregulation of TIMP2 attenuates sepsis-induced AKI through the NF-κb pathway.
Li YM, Zhang J, Su LJ, Kellum JA, Peng ZY
Biochimica et biophysica acta. Molecular basis of disease 2019 Mar 1;1865(3):558-569
Biochimica et biophysica acta. Molecular basis of disease 2019 Mar 1;1865(3):558-569
The attenuation of HIV-1 Tat-induced neurotoxicity by Salvianic acid A and Danshen granule.
Bao D, Wang J, Liu J, Qin T, Liu H
International journal of biological macromolecules 2019 Mar 1;124:863-870
International journal of biological macromolecules 2019 Mar 1;124:863-870
Effects of okadaic acid and hematein on human lung adenocarcinoma A549 cells and responses of mitochondria and endoplasmic reticulum apoptosis pathways.
Wang R, Wang J, Ding N, He S, Zhao Y, Gao P
Translational cancer research 2019 Jun;8(3):968-975
Translational cancer research 2019 Jun;8(3):968-975
Acid sphingomyelinase mediates the noise-induced liver disorder in mice.
Meng X, Gu Z, Xie X, Su Y, Zhang X, Ma H, Guo Y, Liu X, Cheng Y, Chang Y, Bao J
Clinical and experimental pharmacology & physiology 2019 Jun;46(6):556-566
Clinical and experimental pharmacology & physiology 2019 Jun;46(6):556-566
Effect of Gpx3 gene silencing by siRNA on apoptosis and autophagy in chicken cardiomyocytes.
Gong Y, Yang J, Cai J, Liu Q, Zhang JM, Zhang Z
Journal of cellular physiology 2019 Jun;234(6):7828-7838
Journal of cellular physiology 2019 Jun;234(6):7828-7838
Venetoclax Synergistically Enhances the Anti-leukemic Activity of Vosaroxin Against Acute Myeloid Leukemia Cells Ex Vivo.
Liu F, Knight T, Su Y, Edwards H, Wang G, Wang Y, Taub JW, Lin H, Sun L, Ge Y
Targeted oncology 2019 Jun;14(3):351-364
Targeted oncology 2019 Jun;14(3):351-364
Cortisol Excess-Mediated Mitochondrial Damage Induced Hippocampal Neuronal Apoptosis in Mice Following Cold Exposure.
Xu B, Lang LM, Li SZ, Guo JR, Wang JF, Wang D, Zhang LP, Yang HM, Lian S
Cells 2019 Jun 18;8(6)
Cells 2019 Jun 18;8(6)
NLRP3 inflammasome activates interleukin-23/interleukin-17 axis during ischaemia-reperfusion injury in cerebral ischaemia in mice.
Wang H, Zhong D, Chen H, Jin J, Liu Q, Li G
Life sciences 2019 Jun 15;227:101-113
Life sciences 2019 Jun 15;227:101-113
The long non-coding RNA H19 induces hypoxia/reoxygenation injury by up-regulating autophagy in the hepatoma carcinoma cells.
Cui C, Li Z, Wu D
Biological research 2019 Jun 13;52(1):32
Biological research 2019 Jun 13;52(1):32
Design, synthesis and biological evaluation of novel uracil derivatives bearing 1, 2, 3-triazole moiety as thymidylate synthase (TS) inhibitors and as potential antitumor drugs.
Lu GQ, Li XY, Mohamed O K, Wang D, Meng FH
European journal of medicinal chemistry 2019 Jun 1;171:282-296
European journal of medicinal chemistry 2019 Jun 1;171:282-296
Anti-inflammatory and antitumour activity of various extracts and compounds from the fruits of Piper longum L.
Guo Z, Xu J, Xia J, Wu Z, Lei J, Yu J
The Journal of pharmacy and pharmacology 2019 Jul;71(7):1162-1171
The Journal of pharmacy and pharmacology 2019 Jul;71(7):1162-1171
APS could potentially activate hepatic insulin signaling in HFD-induced IR mice.
Sun J, Liu Y, Yu J, Wu J, Gao W, Ran L, Jiang R, Guo M, Han D, Liu B, Wang N, Li Y, Huang H, Zeng L, Gao Y, Li X, Wu Y
Journal of molecular endocrinology 2019 Jul;63(1):77-91
Journal of molecular endocrinology 2019 Jul;63(1):77-91
p57KIP2‑mediated inhibition of human trophoblast apoptosis and promotion of invasion in vitro.
He GQ, Liu GY, Xu WM, Liao HJ, Liu XH, He GL
International journal of molecular medicine 2019 Jul;44(1):281-290
International journal of molecular medicine 2019 Jul;44(1):281-290
Protein kinase RNA-like ER kinase/eukaryotic translation initiation factor 2α pathway attenuates tumor necrosis factor alpha-induced apoptosis in nucleus pulposus cells by activating autophagy.
Chen L, Liu L, Xie ZY, Wang F, Zhu L, Zhang C, Fan P, Sinkemani A, Hong X, Wu XT
Journal of cellular physiology 2019 Jul;234(7):11631-11645
Journal of cellular physiology 2019 Jul;234(7):11631-11645
Chlorogenic acid: A potent molecule that protects cardiomyocytes from TNF-α-induced injury via inhibiting NF-κB and JNK signals.
Tian L, Su CP, Wang Q, Wu FJ, Bai R, Zhang HM, Liu JY, Lu WJ, Wang W, Lan F, Guo SZ
Journal of cellular and molecular medicine 2019 Jul;23(7):4666-4678
Journal of cellular and molecular medicine 2019 Jul;23(7):4666-4678
Melatonin prevents lung injury by regulating apelin 13 to improve mitochondrial dysfunction.
Zhang L, Li F, Su X, Li Y, Wang Y, Fang R, Guo Y, Jin T, Shan H, Zhao X, Yang R, Shan H, Liang H
Experimental & molecular medicine 2019 Jul 4;51(7):1-12
Experimental & molecular medicine 2019 Jul 4;51(7):1-12
A novel hydrogen sulfide-releasing donor, HA-ADT, suppresses the growth of human breast cancer cells through inhibiting the PI3K/AKT/mTOR and Ras/Raf/MEK/ERK signaling pathways.
Dong Q, Yang B, Han JG, Zhang MM, Liu W, Zhang X, Yu HL, Liu ZG, Zhang SH, Li T, Wu DD, Ji XY, Duan SF
Cancer letters 2019 Jul 28;455:60-72
Cancer letters 2019 Jul 28;455:60-72
Suv39h1 promotes facet joint chondrocyte proliferation by targeting miR-15a/Bcl2 in idiopathic scoliosis patients.
Li J, Yang G, Liu S, Wang L, Liang Z, Zhang H
Clinical epigenetics 2019 Jul 23;11(1):107
Clinical epigenetics 2019 Jul 23;11(1):107
Nek2 augments sorafenib resistance by regulating the ubiquitination and localization of β-catenin in hepatocellular carcinoma.
Deng L, Sun J, Chen X, Liu L, Wu D
Journal of experimental & clinical cancer research : CR 2019 Jul 18;38(1):316
Journal of experimental & clinical cancer research : CR 2019 Jul 18;38(1):316
Discovery of N-phenyl-(2,4-dihydroxypyrimidine-5-sulfonamido) phenylurea-based thymidylate synthase (TS) inhibitor as a novel multi-effects antitumor drugs with minimal toxicity.
Li XY, Zhang TJ, Kamara MO, Lu GQ, Xu HL, Wang DP, Meng FH
Cell death & disease 2019 Jul 11;10(7):532
Cell death & disease 2019 Jul 11;10(7):532
Knockdown ATG4C inhibits gliomas progression and promotes temozolomide chemosensitivity by suppressing autophagic flux.
Wen ZP, Zeng WJ, Chen YH, Li H, Wang JY, Cheng Q, Yu J, Zhou HH, Liu ZZ, Xiao J, Chen XP
Journal of experimental & clinical cancer research : CR 2019 Jul 10;38(1):298
Journal of experimental & clinical cancer research : CR 2019 Jul 10;38(1):298
Toxicological exploration of peptide-based cationic liposomes in siRNA delivery.
Zhu Y, Meng Y, Zhao Y, Zhu J, Xu H, Zhang E, Shi L, Du L, Liu G, Zhang C, Xu X, Kang X, Zhen Y, Zhang S
Colloids and surfaces. B, Biointerfaces 2019 Jul 1;179:66-76
Colloids and surfaces. B, Biointerfaces 2019 Jul 1;179:66-76
NPRL2 enhances autophagy and the resistance to Everolimus in castration-resistant prostate cancer.
Chen Z, Jiang Q, Zhu P, Chen Y, Xie X, Du Z, Jiang L, Tang W
The Prostate 2019 Jan;79(1):44-53
The Prostate 2019 Jan;79(1):44-53
Ginsenoside Compound K Regulates Amyloid β via the Nrf2/Keap1 Signaling Pathway in Mice with Scopolamine Hydrobromide-Induced Memory Impairments.
Yang Q, Lin J, Zhang H, Liu Y, Kan M, Xiu Z, Chen X, Lan X, Li X, Shi X, Li N, Qu X
Journal of molecular neuroscience : MN 2019 Jan;67(1):62-71
Journal of molecular neuroscience : MN 2019 Jan;67(1):62-71
Suppressive effect mediated by human adipose-derived stem cells on T cells involves the activation of JNK.
Wang Y, Wang X, Zhou X, Zhu Z, Yang J, Liu F
International journal of molecular medicine 2019 Jan;43(1):177-184
International journal of molecular medicine 2019 Jan;43(1):177-184
Apoptosis induced by ursodeoxycholic acid in human melanoma cells through the mitochondrial pathway.
Yu H, Fu QR, Huang ZJ, Lin JY, Chen QX, Wang Q, Shen DY
Oncology reports 2019 Jan;41(1):213-223
Oncology reports 2019 Jan;41(1):213-223
BPTF promotes hepatocellular carcinoma growth by modulating hTERT signaling and cancer stem cell traits.
Zhao X, Zheng F, Li Y, Hao J, Tang Z, Tian C, Yang Q, Zhu T, Diao C, Zhang C, Chen M, Hu S, Guo P, Zhang L, Liao Y, Yu W, Chen M, Zou L, Guo W, Deng W
Redox biology 2019 Jan;20:427-441
Redox biology 2019 Jan;20:427-441
Nischarin attenuates apoptosis induced by oxidative stress in PC12 cells.
Guo Z, Yuan Y, Guo Y, Wang H, Song C, Huang M
Experimental and therapeutic medicine 2019 Jan;17(1):663-670
Experimental and therapeutic medicine 2019 Jan;17(1):663-670
MiR-181b-5p modulates chemosensitivity of glioma cells to temozolomide by targeting Bcl-2.
Zhang X, Yu J, Zhao C, Ren H, Yuan Z, Zhang B, Zhuang J, Wang J, Feng B
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jan;109:2192-2202
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jan;109:2192-2202
Human amnion-derived mesenchymal stem cell (hAD-MSC) transplantation improves ovarian function in rats with premature ovarian insufficiency (POI) at least partly through a paracrine mechanism.
Ling L, Feng X, Wei T, Wang Y, Wang Y, Wang Z, Tang D, Luo Y, Xiong Z
Stem cell research & therapy 2019 Jan 25;10(1):46
Stem cell research & therapy 2019 Jan 25;10(1):46
Secalonic Acid-F, a Novel Mycotoxin, Represses the Progression of Hepatocellular Carcinoma via MARCH1 Regulation of the PI3K/AKT/β-catenin Signaling Pathway.
Xie L, Li M, Liu D, Wang X, Wang P, Dai H, Yang W, Liu W, Hu X, Zhao M
Molecules (Basel, Switzerland) 2019 Jan 22;24(3)
Molecules (Basel, Switzerland) 2019 Jan 22;24(3)
Anti-breast Cancer Activity of SPG-56 from Sweet Potato in MCF-7 Bearing Mice in Situ through Promoting Apoptosis and Inhibiting Metastasis.
Li Z, Yu Y, Wang M, Xu H, Han B, Jiang P, Ma H, Li Y, Tian C, Zhou D, Li X, Ye X
Scientific reports 2019 Jan 16;9(1):146
Scientific reports 2019 Jan 16;9(1):146
A phenanthroline derivative enhances radiosensitivity of hepatocellular carcinoma cells by inducing mitochondria-dependent apoptosis.
Liu HM, Wu Q, Cao JQ, Wang X, Song Y, Mei WJ, Wang XC
European journal of pharmacology 2019 Jan 15;843:285-291
European journal of pharmacology 2019 Jan 15;843:285-291
Autophagy and Apoptosis Interact to Modulate T-2 Toxin-Induced Toxicity in Liver Cells.
Wu J, Zhou Y, Yuan Z, Yi J, Chen J, Wang N, Tian Y
Toxins 2019 Jan 15;11(1)
Toxins 2019 Jan 15;11(1)
SIRT1 downregulation mediated Manganese-induced neuronal apoptosis through activation of FOXO3a-Bim/PUMA axis.
Zhao X, Liu Y, Zhu G, Liang Y, Liu B, Wu Y, Han M, Sun W, Han Y, Chen G, Jiang J
The Science of the total environment 2019 Jan 1;646:1047-1055
The Science of the total environment 2019 Jan 1;646:1047-1055
CpG Oligodeoxynucleotide Promotes Apoptosis of Human Bladder Cancer T24 Cells Via Inhibition of the Antiapoptotic Factors.
Luo Y, Dong Y, Liang S, Yuan L, Men H, Zhang S, Tian S, Fu X, Dong B, Meng M
Technology in cancer research & treatment 2019 Jan 1;18:1533033819873636
Technology in cancer research & treatment 2019 Jan 1;18:1533033819873636
The Roles of HK2 on Tumorigenesis of Cervical Cancer.
Liu C, Wang X, Zhang Y
Technology in cancer research & treatment 2019 Jan 1;18:1533033819871306
Technology in cancer research & treatment 2019 Jan 1;18:1533033819871306
Effects of resveratrol on regulation on UCP2 and cardiac function in diabetic rats.
Diao J, Wei J, Yan R, Fan G, Lin L, Chen M
Journal of physiology and biochemistry 2019 Feb;75(1):39-51
Journal of physiology and biochemistry 2019 Feb;75(1):39-51
Pterostilbene exerts a protective effect via regulating tunicamycin-induced endoplasmic reticulum stress in mouse preimplantation embryos.
Ullah O, Li Z, Ali I, Xu L, Liu H, Jin HZ, Fang YY, Jin QG, Fang N
In vitro cellular & developmental biology. Animal 2019 Feb;55(2):82-93
In vitro cellular & developmental biology. Animal 2019 Feb;55(2):82-93
Tunicamycin enhances the suppressive effects of cisplatin on lung cancer growth through PTX3 glycosylation via AKT/NF-κB signaling pathway.
Ahmmed B, Khan MN, Nisar MA, Kampo S, Zheng Q, Li Y, Yan Q
International journal of oncology 2019 Feb;54(2):431-442
International journal of oncology 2019 Feb;54(2):431-442
Down-regulation of lncRNA OGFRP1 induces autophagy and growth inhibition by AKT/mTOR signaling pathway in HCAECs.
Zhang X, Liu J, Gu Y, Sun C, Qu F
Cell biology international 2019 Feb;43(2):158-166
Cell biology international 2019 Feb;43(2):158-166
Allicin attenuated chronic social defeat stress induced depressive-like behaviors through suppression of NLRP3 inflammasome.
Gao W, Wang W, Liu G, Zhang J, Yang J, Deng Z
Metabolic brain disease 2019 Feb;34(1):319-329
Metabolic brain disease 2019 Feb;34(1):319-329
JTC-801 inhibits the proliferation and metastasis of the Hep G2 hepatoblastoma cell line by regulating the phosphatidylinositol 3-kinase/protein kinase B signalling pathway.
Zhao B, Hu T
Oncology letters 2019 Feb;17(2):1939-1945
Oncology letters 2019 Feb;17(2):1939-1945
Ebselen protects rat hearts against myocardial ischemia-reperfusion injury.
Cheng B, Zhong JP, Wu FX, Li GL, Ruan QX, Luo G, Jiang H
Experimental and therapeutic medicine 2019 Feb;17(2):1412-1419
Experimental and therapeutic medicine 2019 Feb;17(2):1412-1419
Doxorubicin conjugated with nanodiamonds and in free form commit glioblastoma cells to heterodromous fates.
Chen Z, Wang C, Li TF, Li K, Yue Y, Liu X, Xu HZ, Wen Y, Zhang Q, Han M, Komatsu N, Xu YH, Zhao L, Chen X
Nanomedicine (London, England) 2019 Feb;14(3):335-351
Nanomedicine (London, England) 2019 Feb;14(3):335-351
Exogenous Tetranectin Protects Against 1-Methyl-4-Phenylpyridine-Induced Neurotoxicity by Inhibiting Apoptosis and Autophagy Through Ribosomal Protein S6 Kinase Beta-1.
Xie Q, Liu M, Yan YF, Shen X, Wang ES
World neurosurgery 2019 Feb;122:e375-e382
World neurosurgery 2019 Feb;122:e375-e382
Trans-vaccenic acid inhibits proliferation and induces apoptosis of human nasopharyngeal carcinoma cells via a mitochondrial-mediated apoptosis pathway.
Song J, Wang Y, Fan X, Wu H, Han J, Yang M, Lu L, Nie G
Lipids in health and disease 2019 Feb 9;18(1):46
Lipids in health and disease 2019 Feb 9;18(1):46
Pterostilbene alleviates hydrogen peroxide-induced oxidative stress via nuclear factor erythroid 2 like 2 pathway in mouse preimplantation embryos.
Ullah O, Li Z, Ali I, Xu L, Liu H, Shah SZA, Fang N
The Journal of reproduction and development 2019 Feb 8;65(1):73-81
The Journal of reproduction and development 2019 Feb 8;65(1):73-81
Identification of microRNAs in granulosa cells from patients with different levels of ovarian reserve function and the potential regulatory function of miR-23a in granulosa cell apoptosis.
Luo H, Han Y, Liu J, Zhang Y
Gene 2019 Feb 20;686:250-260
Gene 2019 Feb 20;686:250-260
Soft fibrin matrix downregulates DAB2IP to promote Nanog-dependent growth of colon tumor-repopulating cells.
Zhang M, Xu C, Wang HZ, Peng YN, Li HO, Zhou YJ, Liu S, Wang F, Liu L, Chang Y, Zhao Q, Liu J
Cell death & disease 2019 Feb 15;10(3):151
Cell death & disease 2019 Feb 15;10(3):151
κ-Opioid receptor stimulation reduces palmitate-induced apoptosis via Akt/eNOS signaling pathway.
Cui Y, Feng N, Gu X, Fu F, Li J, Guo H, Liu Y, Zhang S, Li J, Wang Y, Jia M, Yang L, Zhang F, Wang Y, Fan R, Pei J
Lipids in health and disease 2019 Feb 14;18(1):52
Lipids in health and disease 2019 Feb 14;18(1):52
Long non-coding RNA FAM84B-AS promotes resistance of gastric cancer to platinum drugs through inhibition of FAM84B expression.
Zhang Y, Li Q, Yu S, Zhu C, Zhang Z, Cao H, Xu J
Biochemical and biophysical research communications 2019 Feb 12;509(3):753-762
Biochemical and biophysical research communications 2019 Feb 12;509(3):753-762
Autophagic flux blockage in alveolar epithelial cells is essential in silica nanoparticle-induced pulmonary fibrosis.
Zhao X, Wei S, Li Z, Lin C, Zhu Z, Sun D, Bai R, Qian J, Gao X, Chen G, Xu Z
Cell death & disease 2019 Feb 12;10(2):127
Cell death & disease 2019 Feb 12;10(2):127
Protective Effect of Koumine, an Alkaloid from Gelsemium Sempervirens, on Injury Induced by H₂O₂ in IPEC-J2 Cells.
Yuan Z, Liang Z, Yi J, Chen X, Li R, Wu Y, Wu J, Sun Z
International journal of molecular sciences 2019 Feb 11;20(3)
International journal of molecular sciences 2019 Feb 11;20(3)
Identification of diterpenoid compounds that interfere with Fli-1 DNA binding to suppress leukemogenesis.
Liu T, Xia L, Yao Y, Yan C, Fan Y, Gajendran B, Yang J, Li YJ, Chen J, Filmus J, Spaner DE, Zacksenhaus E, Hao X, Ben-David Y
Cell death & disease 2019 Feb 11;10(2):117
Cell death & disease 2019 Feb 11;10(2):117
Cordycepin sensitizes breast cancer cells toward irradiation through elevating ROS production involving Nrf2.
Dong J, Li Y, Xiao H, Luo D, Zhang S, Zhu C, Jiang M, Cui M, Lu L, Fan S
Toxicology and applied pharmacology 2019 Feb 1;364:12-21
Toxicology and applied pharmacology 2019 Feb 1;364:12-21
Silence of S1 RNA binding domain 1 represses cell growth and promotes apoptosis in human non-small cell lung cancer cells.
Zhang T, Cheng G, Deng L, Yang Y, Sun L, Chen P, He X, Su D, Bi N, Qiu B
Translational lung cancer research 2019 Dec;8(6):760-774
Translational lung cancer research 2019 Dec;8(6):760-774
Bruceine D inhibits tumor growth and stem cell-like traits of osteosarcoma through inhibition of STAT3 signaling pathway.
Wang S, Hu H, Zhong B, Shi D, Qing X, Cheng C, Deng X, Zhang Z, Shao Z
Cancer medicine 2019 Dec;8(17):7345-7358
Cancer medicine 2019 Dec;8(17):7345-7358
Propofol Attenuates Hypoxia/Reoxygenation-Induced Apoptosis and Autophagy in HK-2 Cells by Inhibiting JNK Activation.
Wang H, Peng X, Huang Y, Xiao Y, Wang Z, Zhan L
Yonsei medical journal 2019 Dec;60(12):1195-1202
Yonsei medical journal 2019 Dec;60(12):1195-1202
Protective effect of miR-20a against hypoxia/reoxygenation treatment on cardiomyocytes cell viability and cell apoptosis by targeting TLR4 and inhibiting p38 MAPK/JNK signaling.
Gong XY, Zhang Y
In vitro cellular & developmental biology. Animal 2019 Dec;55(10):793-800
In vitro cellular & developmental biology. Animal 2019 Dec;55(10):793-800
Ginsenoside Rb1 mitigates oxidative stress and apoptosis induced by methylglyoxal in SH-SY5Y cells via the PI3K/Akt pathway.
Nan F, Sun G, Xie W, Ye T, Sun X, Zhou P, Dong X, Sun J, Sun X, Zhang M
Molecular and cellular probes 2019 Dec;48:101469
Molecular and cellular probes 2019 Dec;48:101469
Anti-tumour effects of red blood cell membrane-camouflaged black phosphorous quantum dots combined with chemotherapy and anti-inflammatory therapy.
Huang X, Wu B, Li J, Shang Y, Chen W, Nie X, Gui R
Artificial cells, nanomedicine, and biotechnology 2019 Dec;47(1):968-979
Artificial cells, nanomedicine, and biotechnology 2019 Dec;47(1):968-979
Ribociclib (LEE011) suppresses cell proliferation and induces apoptosis of MDA-MB-231 by inhibiting CDK4/6-cyclin D-Rb-E2F pathway.
Li T, Xiong Y, Wang Q, Chen F, Zeng Y, Yu X, Wang Y, Zhou F, Zhou Y
Artificial cells, nanomedicine, and biotechnology 2019 Dec;47(1):4001-4011
Artificial cells, nanomedicine, and biotechnology 2019 Dec;47(1):4001-4011
Molecular mechanism of miR-204 regulates proliferation, apoptosis and autophagy of cervical cancer cells by targeting ATF2.
Li N, Guo X, Liu L, Wang L, Cheng R
Artificial cells, nanomedicine, and biotechnology 2019 Dec;47(1):2529-2535
Artificial cells, nanomedicine, and biotechnology 2019 Dec;47(1):2529-2535
Transarterial Infusion of iRGD-Modified ZrO(2) Nanoparticles with Lipiodol Improves the Tissue Distribution of Doxorubicin and Its Antitumor Efficacy.
Xie Y, Qi X, Xu K, Meng X, Chen X, Wang F, Zhong H
Journal of vascular and interventional radiology : JVIR 2019 Dec;30(12):2026-2035.e2
Journal of vascular and interventional radiology : JVIR 2019 Dec;30(12):2026-2035.e2
Histone deacetylases inhibitor MS-275 suppresses human esophageal squamous cell carcinoma cell growth and progression via the PI3K/Akt/mTOR pathway.
Ma S, Liu T, Xu L, Wang Y, Zhou J, Huang T, Li P, Liu H, Zhang Y, Zhou X, Cui Y, Zang X, Wang Y, Guan F
Journal of cellular physiology 2019 Dec;234(12):22400-22410
Journal of cellular physiology 2019 Dec;234(12):22400-22410
Long non-coding RNA GAPLINC promotes angiogenesis by regulating miR-211 under hypoxia in human umbilical vein endothelial cells.
He Y, Wu Z, Qiu C, Wang X, Xiang Y, Lu T, He Y, Shang T, Zhu Q, Wang X, Zeng Q, Zhang H, Li D
Journal of cellular and molecular medicine 2019 Dec;23(12):8090-8100
Journal of cellular and molecular medicine 2019 Dec;23(12):8090-8100
Effects of kojic acid on boar sperm quality and anti-bacterial activity during liquid preservation at 17 C.
Shaoyong W, Li Q, Ren Z, Xiao J, Diao Z, Yang G, Pang W
Theriogenology 2019 Dec;140:124-135
Theriogenology 2019 Dec;140:124-135
HDAC5-mediated deacetylation and nuclear localisation of SOX9 is critical for tamoxifen resistance in breast cancer.
Xue Y, Lian W, Zhi J, Yang W, Li Q, Guo X, Gao J, Qu H, Lin W, Li Z, Lai L, Wang Q
British journal of cancer 2019 Dec;121(12):1039-1049
British journal of cancer 2019 Dec;121(12):1039-1049
Hepatotoxicity and mechanism study of chrysophanol-8-O-glucoside in vitro.
Lin L, Yuan F, Liu Y, Zhong M, Xie T, Ni J, Li H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Dec;120:109531
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Dec;120:109531
miR-885-5p Negatively Regulates Warburg Effect by Silencing Hexokinase 2 in Liver Cancer.
Xu F, Yan JJ, Gan Y, Chang Y, Wang HL, He XX, Zhao Q
Molecular therapy. Nucleic acids 2019 Dec 6;18:308-319
Molecular therapy. Nucleic acids 2019 Dec 6;18:308-319
Hydrogen sulfide attenuates mitochondrial dysfunction-induced cellular senescence and apoptosis in alveolar epithelial cells by upregulating sirtuin 1.
Guan R, Cai Z, Wang J, Ding M, Li Z, Xu J, Li Y, Li J, Yao H, Liu W, Qian J, Deng B, Tang C, Sun D, Lu W
Aging 2019 Dec 23;11(24):11844-11864
Aging 2019 Dec 23;11(24):11844-11864
Combination of the natural compound Periplocin and TRAIL induce esophageal squamous cell carcinoma apoptosis in vitro and in vivo: Implication in anticancer therapy.
Han L, Dai S, Li Z, Zhang C, Wei S, Zhao R, Zhang H, Zhao L, Shan B
Journal of experimental & clinical cancer research : CR 2019 Dec 21;38(1):501
Journal of experimental & clinical cancer research : CR 2019 Dec 21;38(1):501
Genome-wide CRISPR screen identifies ELP5 as a determinant of gemcitabine sensitivity in gallbladder cancer.
Xu S, Zhan M, Jiang C, He M, Yang L, Shen H, Huang S, Huang X, Lin R, Shi Y, Liu Q, Chen W, Mohan M, Wang J
Nature communications 2019 Dec 2;10(1):5492
Nature communications 2019 Dec 2;10(1):5492
Upregulating MicroRNA-410 or Downregulating Wnt-11 Increases Osteoblasts and Reduces Osteoclasts to Alleviate Osteonecrosis of the Femoral Head.
Yin Y, Ding L, Hou Y, Jiang H, Zhang J, Dai Z, Zhang G
Nanoscale research letters 2019 Dec 18;14(1):383
Nanoscale research letters 2019 Dec 18;14(1):383
Protease-activated receptor 2 (PAR-2) antagonist AZ3451 as a novel therapeutic agent for osteoarthritis.
Huang X, Ni B, Xi Y, Chu X, Zhang R, You H
Aging 2019 Dec 16;11(24):12532-12545
Aging 2019 Dec 16;11(24):12532-12545
LncRNA AC007271.3 promotes cell proliferation, invasion, migration and inhibits cell apoptosis of OSCC via the Wnt/β-catenin signaling pathway.
Shao TR, Zheng ZN, Chen YC, Wu QQ, Huang GZ, Li F, Zeng WS, Lv XZ
Life sciences 2019 Dec 15;239:117087
Life sciences 2019 Dec 15;239:117087
TBX3 deficiency accelerates apoptosis in cardiomyoblasts through regulation of P21 expression.
Cao M, Zhu B, Sun Y, Zhao X, Qiu G, Fu W, Jiang H
Life sciences 2019 Dec 15;239:117040
Life sciences 2019 Dec 15;239:117040
Melatonin ameliorates cerebral ischemia/reperfusion injury through SIRT3 activation.
Liu L, Chen H, Jin J, Tang Z, Yin P, Zhong D, Li G
Life sciences 2019 Dec 15;239:117036
Life sciences 2019 Dec 15;239:117036
HMGB1/TLR4 promotes apoptosis and reduces autophagy of hippocampal neurons in diabetes combined with OSA.
Guo X, Shi Y, Du P, Wang J, Han Y, Sun B, Feng J
Life sciences 2019 Dec 15;239:117020
Life sciences 2019 Dec 15;239:117020
Sulforaphane inhibits gastric cancer stem cells via suppressing sonic hedgehog pathway.
Ge M, Zhang L, Cao L, Xie C, Li X, Li Y, Meng Y, Chen Y, Wang X, Chen J, Zhang Q, Shao J, Zhong C
International journal of food sciences and nutrition 2019 Aug;70(5):570-578
International journal of food sciences and nutrition 2019 Aug;70(5):570-578
Melatonin promotes secondary hair follicle development of early postnatal cashmere goat and improves cashmere quantity and quality by enhancing antioxidant capacity and suppressing apoptosis.
Yang CH, Xu JH, Ren QC, Duan T, Mo F, Zhang W
Journal of pineal research 2019 Aug;67(1):e12569
Journal of pineal research 2019 Aug;67(1):e12569
UNBS5162 as a novel naphthalimide holds efficacy in human gastric carcinoma cell behaviors mediated by AKT/ERK signaling pathway.
Li HH, Song XX, Liu B, Yang WP
Drug development and industrial pharmacy 2019 Aug;45(8):1306-1312
Drug development and industrial pharmacy 2019 Aug;45(8):1306-1312
Upregulation of miR‑95-3p inhibits growth of osteosarcoma by targeting HDGF.
Liu X, Ma W, Ma J, Xiao L, Hao D
Pathology, research and practice 2019 Aug;215(8):152492
Pathology, research and practice 2019 Aug;215(8):152492
The expression of Bcl-2 in adenomyosis and its effect on proliferation, migration, and apoptosis of endometrial stromal cells.
Li J, Yanyan M, Mu L, Chen X, Zheng W
Pathology, research and practice 2019 Aug;215(8):152477
Pathology, research and practice 2019 Aug;215(8):152477
RING finger protein 10 is a potential drug target for diabetic vascular complications.
Li S, Yu G, Huang W, Wang R, Pu P, Chen M
Molecular medicine reports 2019 Aug;20(2):931-938
Molecular medicine reports 2019 Aug;20(2):931-938
HSF1 phosphorylation by cyclosporin A confers hyperthermia sensitivity through suppression of HSP expression.
Shao J, Han B, Cao P, Zhang B, Liu M, Li D, Zhou N, Hao Q, Duan X, Chang Y, Nakai A, Fan Y, Tan K
Biochimica et biophysica acta. Gene regulatory mechanisms 2019 Aug;1862(8):846-857
Biochimica et biophysica acta. Gene regulatory mechanisms 2019 Aug;1862(8):846-857
Galectin-3 Mediates Endothelial-to-Mesenchymal Transition in Pulmonary Arterial Hypertension.
Li T, Zha L, Luo H, Li S, Zhao L, He J, Li X, Qi Q, Liu Y, Yu Z
Aging and disease 2019 Aug;10(4):731-745
Aging and disease 2019 Aug;10(4):731-745
Platelet-Membrane-Camouflaged Black Phosphorus Quantum Dots Enhance Anticancer Effect Mediated by Apoptosis and Autophagy.
Shang Y, Wang Q, Wu B, Zhao Q, Li J, Huang X, Chen W, Gui R
ACS applied materials & interfaces 2019 Aug 7;11(31):28254-28266
ACS applied materials & interfaces 2019 Aug 7;11(31):28254-28266
[Effect of the chemoprotectant tempol on anti-tumor activity of cisplatin].
Ye S, Zeng S, Huang M, Chen J, Chen X, Xu P, Wang Q, Gao W, Yang B, Hao B, Huang W, Liu Q
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2019 Aug 30;39(8):883-890
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2019 Aug 30;39(8):883-890
EXT1, Regulated by MiR-665, Promotes Cell Apoptosis via ERK1/2 Signaling Pathway in Acute Lymphoblastic Leukemia.
Liu NW, Huang X, Liu S, Lu Y
Medical science monitor : international medical journal of experimental and clinical research 2019 Aug 29;25:6491-6503
Medical science monitor : international medical journal of experimental and clinical research 2019 Aug 29;25:6491-6503
Resveratrol induces apoptosis of benign prostatic hyperplasia epithelial cell line (BPH-1) through p38 MAPK-FOXO3a pathway.
Li C, Hu WL, Lu MX, Xiao GF
BMC complementary and alternative medicine 2019 Aug 29;19(1):233
BMC complementary and alternative medicine 2019 Aug 29;19(1):233
HO-1 reduces heat stress-induced apoptosis in bovine granulosa cells by suppressing oxidative stress.
Wang Y, Yang C, Elsheikh NAH, Li C, Yang F, Wang G, Li L
Aging 2019 Aug 12;11(15):5535-5547
Aging 2019 Aug 12;11(15):5535-5547
Exogenous H(2)S reduces the acetylation levels of mitochondrial respiratory enzymes via regulating the NAD(+)-SIRT3 pathway in cardiac tissues of db/db mice.
Sun Y, Teng Z, Sun X, Zhang L, Chen J, Wang B, Lu F, Liu N, Yu M, Peng S, Wang Y, Zhao D, Zhao Y, Ren H, Cheng Z, Dong S, Lu F, Zhang W
American journal of physiology. Endocrinology and metabolism 2019 Aug 1;317(2):E284-E297
American journal of physiology. Endocrinology and metabolism 2019 Aug 1;317(2):E284-E297
SALL4 induces radioresistance in nasopharyngeal carcinoma via the ATM/Chk2/p53 pathway.
Nie X, Guo E, Wu C, Liu D, Sun W, Zhang L, Long G, Mei Q, Wu K, Xiong H, Hu G
Cancer medicine 2019 Apr;8(4):1779-1792
Cancer medicine 2019 Apr;8(4):1779-1792
Restorative effect of modified dioscorea pills on the structure of hippocampal neurovascular unit in an animal model of chronic cerebral hypoperfusion.
Li HB
Heliyon 2019 Apr;5(4):e01567
Heliyon 2019 Apr;5(4):e01567
Cloning of a new testis-enriched gene C4orf22 and its role in cell cycle and apoptosis in mouse spermatogenic cells.
Li H, Dai Y, Luo Z, Nie D
Molecular biology reports 2019 Apr;46(2):2029-2038
Molecular biology reports 2019 Apr;46(2):2029-2038
Bax inhibitor-1 overexpression in prelimbic cortex protects rats against depression-like behavior induced by olfactory bulbectomy and reduces apoptotic and inflammatory signals.
Li D, Cai Z, Wu J, Zhang Y
Neurological research 2019 Apr;41(4):369-377
Neurological research 2019 Apr;41(4):369-377
Protective effects of ethyl gallate on H(2)O(2)-induced mitochondrial dysfunction in PC12 cells.
Chen L, Wu X, Shen T, Wang X, Wang S, Wang J, Ren D
Metabolic brain disease 2019 Apr;34(2):545-555
Metabolic brain disease 2019 Apr;34(2):545-555
Luteolin attenuates glucocorticoid-induced osteoporosis by regulating ERK/Lrp-5/GSK-3β signaling pathway in vivo and in vitro.
Jing Z, Wang C, Yang Q, Wei X, Jin Y, Meng Q, Liu Q, Liu Z, Ma X, Liu K, Sun H, Liu M
Journal of cellular physiology 2019 Apr;234(4):4472-4490
Journal of cellular physiology 2019 Apr;234(4):4472-4490
Astragaloside IV enhances taxol chemosensitivity of breast cancer via caveolin-1-targeting oxidant damage.
Zheng Y, Dai Y, Liu W, Wang N, Cai Y, Wang S, Zhang F, Liu P, Chen Q, Wang Z
Journal of cellular physiology 2019 Apr;234(4):4277-4290
Journal of cellular physiology 2019 Apr;234(4):4277-4290
Heme oxygenase 1 regulates apoptosis induced by heat stress in bovine ovarian granulosa cells via the ERK1/2 pathway.
Wang YR, Chen KL, Li CM, Li L, Wang GL
Journal of cellular physiology 2019 Apr;234(4):3961-3972
Journal of cellular physiology 2019 Apr;234(4):3961-3972
Deficiency of TPPP2, a factor linked to oligoasthenozoospermia, causes subfertility in male mice.
Zhu F, Yan P, Zhang J, Cui Y, Zheng M, Cheng Y, Guo Y, Yang X, Guo X, Zhu H
Journal of cellular and molecular medicine 2019 Apr;23(4):2583-2594
Journal of cellular and molecular medicine 2019 Apr;23(4):2583-2594
Potent effects of dioscin against hepatocellular carcinoma through regulating TP53-induced glycolysis and apoptosis regulator (TIGAR)-mediated apoptosis, autophagy, and DNA damage.
Mao Z, Han X, Chen D, Xu Y, Xu L, Yin L, Sun H, Qi Y, Fang L, Liu K, Peng J
British journal of pharmacology 2019 Apr;176(7):919-937
British journal of pharmacology 2019 Apr;176(7):919-937
Ribociclib, a selective cyclin D kinase 4/6 inhibitor, inhibits proliferation and induces apoptosis of human cervical cancer in vitro and in vivo.
Xiong Y, Li T, Assani G, Ling H, Zhou Q, Zeng Y, Zhou F, Zhou Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Apr;112:108602
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Apr;112:108602
Host defense peptide Hymenochirin-1B induces lung cancer cell apoptosis and cell cycle arrest through the mitochondrial pathway.
Zhang Y, Sun C, Xiao G, Gu Y
Biochemical and biophysical research communications 2019 Apr 30;512(2):269-275
Biochemical and biophysical research communications 2019 Apr 30;512(2):269-275
Impact of Taurine on the proliferation and apoptosis of human cervical carcinoma cells and its mechanism.
Li H, Ruan WJ, Liu LQ, Wan HF, Yang XH, Zhu WF, Yu LH, Zhang XL, Wan FS
Chinese medical journal 2019 Apr 20;132(8):948-956
Chinese medical journal 2019 Apr 20;132(8):948-956
Ginsenoside Rk1 induces cell cycle arrest and apoptosis in MDA-MB-231 triple negative breast cancer cells.
Hong Y, Fan D
Toxicology 2019 Apr 15;418:22-31
Toxicology 2019 Apr 15;418:22-31
Novel half-sandwich iridium OˆC (carbene)-Complexes: In vitro and in vivo tumor growth suppression and pro-apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes.
Xu Z, Zhang Y, Zhang S, Jia X, Zhong G, Yang Y, Du Q, Li J, Liu Z
Cancer letters 2019 Apr 10;447:75-85
Cancer letters 2019 Apr 10;447:75-85
Cadmium-induced apoptosis through reactive oxygen species-mediated mitochondrial oxidative stress and the JNK signaling pathway in TM3 cells, a model of mouse Leydig cells.
Wang S, Ren X, Hu X, Zhou L, Zhang C, Zhang M
Toxicology and applied pharmacology 2019 Apr 1;368:37-48
Toxicology and applied pharmacology 2019 Apr 1;368:37-48
The Orexin-A-Regulated Akt/mTOR Pathway Promotes Cell Proliferation Through Inhibiting Apoptosis in Pancreatic Cancer Cells.
Suo L, Chang X, Zhao Y
Frontiers in endocrinology 2018;9:647
Frontiers in endocrinology 2018;9:647
Analysis of microRNA Expression Profiles Induced by Yiqifumai Injection in Rats with Chronic Heart Failure.
Zhao Y, Li Y, Tong L, Liang X, Zhang H, Li L, Fan G, Wang Y
Frontiers in physiology 2018;9:48
Frontiers in physiology 2018;9:48
β-Sitosterol and Gemcitabine Exhibit Synergistic Anti-pancreatic Cancer Activity by Modulating Apoptosis and Inhibiting Epithelial-Mesenchymal Transition by Deactivating Akt/GSK-3β Signaling.
Cao ZQ, Wang XX, Lu L, Xu JW, Li XB, Zhang GR, Ma ZJ, Shi AC, Wang Y, Song YJ
Frontiers in pharmacology 2018;9:1525
Frontiers in pharmacology 2018;9:1525
Protective Effects of Costunolide Against D-Galactosamine and Lipopolysaccharide-Induced Acute Liver Injury in Mice.
Mao J, Yi M, Wang R, Huang Y, Chen M
Frontiers in pharmacology 2018;9:1469
Frontiers in pharmacology 2018;9:1469
Add-On therapy with Chinese herb medicine Bo-Er-Ning capsule (BENC) improves outcomes of gastric cancer patients: a randomized clinical trial followed with bioinformatics-assisted mechanism study.
Pan B, Zang J, He J, Wang Z, Liu L
American journal of cancer research 2018;8(6):1090-1105
American journal of cancer research 2018;8(6):1090-1105
Targeting P-Glycoprotein: Nelfinavir Reverses Adriamycin Resistance in K562/ADR Cells.
Liu W, Meng Q, Sun Y, Wang C, Huo X, Liu Z, Sun P, Sun H, Ma X, Liu K
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;51(4):1616-1631
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;51(4):1616-1631
High Concentration of Aspirin Induces Apoptosis in Rat Tendon Stem Cells via Inhibition of the Wnt/β-Catenin Pathway.
Wang Y, Tang H, He G, Shi Y, Kang X, Lyu J, Zhou M, Zhu M, Zhang J, Tang K
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;50(6):2046-2059
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;50(6):2046-2059
Alpha-Lipoic Acid Protects Human Aortic Endothelial Cells Against H2O2-Induced Injury and Inhibits Atherosclerosis in Ovariectomized Low Density Lipoprotein Receptor Knock-Out Mice.
Shen D, Tian L, Shen T, Sun H, Liu P
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;47(6):2261-2277
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;47(6):2261-2277
HSP70/HSP90-Organizing Protein Contributes to Gastric Cancer Progression in an Autocrine Fashion and Predicts Poor Survival in Gastric Cancer.
Zhai E, Liang W, Lin Y, Huang L, He X, Cai S, Chen J, Zhang N, Li J, Zhang Q, He Y, Zeng Z, Chen M, Xu L, Peng S
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;47(2):879-892
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;47(2):879-892
Novel Serum Biomarkers Detected by Protein Array in Polycystic Ovary Syndrome with Low Progesterone Level.
Zheng Q, Zhou F, Cui X, Liu M, Li Y, Liu S, Tan J, Yan Q
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;46(6):2297-2310
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;46(6):2297-2310
Atorvastatin Attenuates Myocardial Hypertrophy in Spontaneously Hypertensive Rats via the C/EBPβ/PGC-1α/UCP3 Pathway.
Chen Y, Chang Y, Zhang N, Guo X, Sun G, Sun Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;46(3):1009-1018
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;46(3):1009-1018
MnTMPyP inhibits paraquat-induced pulmonary epithelial-like cell injury by inhibiting oxidative stress.
Xu Y, Sun D, Song C, Wang R, Dong X
The Journal of toxicological sciences 2018;43(9):545-555
The Journal of toxicological sciences 2018;43(9):545-555
MiR-320 regulates cardiomyocyte apoptosis induced by ischemia-reperfusion injury by targeting AKIP1.
Tian ZQ, Jiang H, Lu ZB
Cellular & molecular biology letters 2018;23:41
Cellular & molecular biology letters 2018;23:41
Hydrogen Sulfide Alleviates Lipopolysaccharide-Induced Diaphragm Dysfunction in Rats by Reducing Apoptosis and Inflammation through ROS/MAPK and TLR4/NF-κB Signaling Pathways.
Zhang GY, Lu D, Duan SF, Gao YR, Liu SY, Hong Y, Dong PZ, Chen YG, Li T, Wang DY, Cheng XS, He F, Wei JS, Li GY, Zhang QY, Wu DD, Ji XY
Oxidative medicine and cellular longevity 2018;2018:9647809
Oxidative medicine and cellular longevity 2018;2018:9647809
Portulaca Extract Attenuates Development of Dextran Sulfate Sodium Induced Colitis in Mice through Activation of PPARγ.
Kong R, Luo H, Wang N, Li J, Xu S, Chen K, Feng J, Wu L, Li S, Liu T, Lu X, Xia Y, Shi Y, Zhou Y, He W, Dai Q, Zheng Y, Lu J
PPAR research 2018;2018:6079101
PPAR research 2018;2018:6079101
The Protective Effects of Levo-Tetrahydropalmatine on ConA-Induced Liver Injury Are via TRAF6/JNK Signaling.
Yu Q, Liu T, Li S, Feng J, Wu L, Wang W, Chen K, Xia Y, Niu P, Xu L, Wang F, Dai W, Zhou Y, Guo C
Mediators of inflammation 2018;2018:4032484
Mediators of inflammation 2018;2018:4032484
Proscillaridin A Promotes Oxidative Stress and ER Stress, Inhibits STAT3 Activation, and Induces Apoptosis in A549 Lung Adenocarcinoma Cells.
Maryam A, Mehmood T, Yan Q, Li Y, Khan M, Ma T
Oxidative medicine and cellular longevity 2018;2018:3853409
Oxidative medicine and cellular longevity 2018;2018:3853409
Hydrogen Sulfide Alleviates Acute Myocardial Ischemia Injury by Modulating Autophagy and Inflammation Response under Oxidative Stress.
Bai YD, Yang YR, Mu XP, Lin G, Wang YP, Jin S, Chen Y, Wang MJ, Zhu YC
Oxidative medicine and cellular longevity 2018;2018:3402809
Oxidative medicine and cellular longevity 2018;2018:3402809
The Hepatoprotection by Oleanolic Acid Preconditioning: Focusing on PPARα Activation.
Wang W, Chen K, Xia Y, Mo W, Wang F, Dai W, Niu P
PPAR research 2018;2018:3180396
PPAR research 2018;2018:3180396
Activating the PGC-1α/TERT Pathway by Catalpol Ameliorates Atherosclerosis via Modulating ROS Production, DNA Damage, and Telomere Function: Implications on Mitochondria and Telomere Link.
Zhang Y, Wang C, Jin Y, Yang Q, Meng Q, Liu Q, Dai Y, Cai L, Liu Z, Liu K, Sun H
Oxidative medicine and cellular longevity 2018;2018:2876350
Oxidative medicine and cellular longevity 2018;2018:2876350
Fucosterol Protects against Concanavalin A-Induced Acute Liver Injury: Focus on P38 MAPK/NF-κB Pathway Activity.
Mo W, Wang C, Li J, Chen K, Xia Y, Li S, Xu L, Lu X, Wang W, Guo C
Gastroenterology research and practice 2018;2018:2824139
Gastroenterology research and practice 2018;2018:2824139
Proscillaridin A induces apoptosis, inhibits STAT3 activation and augments doxorubicin toxicity in prostate cancer cells.
He Y, Khan M, Yang J, Yao M, Yu S, Gao H
International journal of medical sciences 2018;15(8):832-839
International journal of medical sciences 2018;15(8):832-839
SND1 acts as an anti-apoptotic factor via regulating the expression of lncRNA UCA1 in hepatocellular carcinoma.
Cui X, Zhao C, Yao X, Qian B, Su C, Ren Y, Yao Z, Gao X, Yang J
RNA biology 2018;15(10):1364-1375
RNA biology 2018;15(10):1364-1375
Notch signaling inhibitor DAPT provides protection against acute craniocerebral injury.
Zhang HM, Liu P, Jiang C, Jin XQ, Liu RN, Li SQ, Zhao Y
PloS one 2018;13(2):e0193037
PloS one 2018;13(2):e0193037
Codelivery of doxorubicin and MDR1-siRNA by mesoporous silica nanoparticles-polymerpolyethylenimine to improve oral squamous carcinoma treatment.
Wang D, Xu X, Zhang K, Sun B, Wang L, Meng L, Liu Q, Zheng C, Yang B, Sun H
International journal of nanomedicine 2018;13:187-198
International journal of nanomedicine 2018;13:187-198
HDAC1 Silence Promotes Neuroprotective Effects of Human Umbilical Cord-Derived Mesenchymal Stem Cells in a Mouse Model of Traumatic Brain Injury via PI3K/AKT Pathway.
Xu L, Xing Q, Huang T, Zhou J, Liu T, Cui Y, Cheng T, Wang Y, Zhou X, Yang B, Yang GL, Zhang J, Zang X, Ma S, Guan F
Frontiers in cellular neuroscience 2018;12:498
Frontiers in cellular neuroscience 2018;12:498
Realgar, a traditional Chinese medicine, induces apoptosis of HPV16-positive cervical cells through a HPV16 E7-related pathway.
Ding W, Ji T, Xiong W, Li T, Pu D, Liu R
Drug design, development and therapy 2018;12:3459-3469
Drug design, development and therapy 2018;12:3459-3469
XRCC1 rs1799782 (C194T) polymorphism correlated with tumor metastasis and molecular subtypes in breast cancer.
Li Q, Ma R, Zhang M
OncoTargets and therapy 2018;11:8435-8444
OncoTargets and therapy 2018;11:8435-8444
Brevilin A promotes oxidative stress and induces mitochondrial apoptosis in U87 glioblastoma cells.
Wang J, Li M, Cui X, Lv D, Jin L, Khan M, Ma T
OncoTargets and therapy 2018;11:7031-7040
OncoTargets and therapy 2018;11:7031-7040
Transcriptional Repression of p53 by PAX3 Contributes to Gliomagenesis and Differentiation of Glioma Stem Cells.
Zhu H, Wang H, Huang Q, Liu Q, Guo Y, Lu J, Li X, Xue C, Han Q
Frontiers in molecular neuroscience 2018;11:187
Frontiers in molecular neuroscience 2018;11:187
Combination Treatment of Icariin and L-DOPA Against 6-OHDA-Lesioned Dopamine Neurotoxicity.
Lu DS, Chen C, Zheng YX, Li DD, Wang GQ, Liu J, Shi J, Zhang F
Frontiers in molecular neuroscience 2018;11:155
Frontiers in molecular neuroscience 2018;11:155
Pyrroline-5-carboxylate reductase 1 promotes cell proliferation via inhibiting apoptosis in human malignant melanoma.
Ye Y, Wu Y, Wang J
Cancer management and research 2018;10:6399-6407
Cancer management and research 2018;10:6399-6407
Therapeutic Potential of a Prolyl Hydroxylase Inhibitor FG-4592 for Parkinson's Diseases in Vitro and in Vivo: Regulation of Redox Biology and Mitochondrial Function.
Li X, Cui XX, Chen YJ, Wu TT, Xu H, Yin H, Wu YC
Frontiers in aging neuroscience 2018;10:121
Frontiers in aging neuroscience 2018;10:121
ABT737 reverses cisplatin resistance by targeting glucose metabolism of human ovarian cancer cells.
Xu Y, Gao W, Zhang Y, Wu S, Liu Y, Deng X, Xie L, Yang J, Yu H, Su J, Sun L
International journal of oncology 2018 Sep;53(3):1055-1068
International journal of oncology 2018 Sep;53(3):1055-1068
Knockdown of NUPR1 inhibits the growth of U266 and RPMI8226 multiple myeloma cell lines via activating PTEN and caspase activation‑dependent apoptosis.
Zeng C, Li X, Li A, Yi B, Peng X, Huang X, Chen J
Oncology reports 2018 Sep;40(3):1487-1494
Oncology reports 2018 Sep;40(3):1487-1494
Interferon Gamma Inhibits CXCL8-Induced Proliferation and Migration of Pancreatic Cancer BxPC-3 Cell Line via a RhoGDI2/Rac1/NF-κB Signaling Pathway.
Zhang M, Ding G, Zhou L, Shen T, Xu X, Zhao T, Jia S, Cao L
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2018 Sep;38(9):413-422
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2018 Sep;38(9):413-422
Activation of STAT3 and Bcl-2 and reduction of reactive oxygen species (ROS) promote radioresistance in breast cancer and overcome of radioresistance with niclosamide.
Lu L, Dong J, Wang L, Xia Q, Zhang D, Kim H, Yin T, Fan S, Shen Q
Oncogene 2018 Sep;37(39):5292-5304
Oncogene 2018 Sep;37(39):5292-5304
TMCO1 is essential for ovarian follicle development by regulating ER Ca(2+) store of granulosa cells.
Sun Z, Zhang H, Wang X, Wang QC, Zhang C, Wang JQ, Wang YH, An CQ, Yang KY, Wang Y, Gao F, Guo C, Tang TS
Cell death and differentiation 2018 Sep;25(9):1686-1701
Cell death and differentiation 2018 Sep;25(9):1686-1701
UBIAD1 protects against oxygen-glucose deprivation/reperfusion-induced multiple subcellular organelles injury through PI3K/AKT pathway in N2A cells.
Huang Y, Hu Z
Journal of cellular physiology 2018 Sep;233(9):7480-7496
Journal of cellular physiology 2018 Sep;233(9):7480-7496
The protective effects of distal ischemic treatment on apoptosis and mitochondrial permeability in the hippocampus after cardiopulmonary resuscitation.
Zhou X, Yong L, Huang Y, Zhu S, Song X, Li B, Zhu J, Wang H
Journal of cellular physiology 2018 Sep;233(9):6902-6910
Journal of cellular physiology 2018 Sep;233(9):6902-6910
LncRNA TDRG1 enhances tumorigenicity in endometrial carcinoma by binding and targeting VEGF-A protein.
Chen S, Wang LL, Sun KX, Liu Y, Guan X, Zong ZH, Zhao Y
Biochimica et biophysica acta. Molecular basis of disease 2018 Sep;1864(9 Pt B):3013-3021
Biochimica et biophysica acta. Molecular basis of disease 2018 Sep;1864(9 Pt B):3013-3021
Overexpression of SMARCA2 or CAMK2D is associated with cisplatin resistance in human epithelial ovarian cancer.
Xu X, Zheng Z, Jia L, Suo S, Liu B, Shao T, Tu Q, Hua Y, Xu H
Oncology letters 2018 Sep;16(3):3796-3804
Oncology letters 2018 Sep;16(3):3796-3804
Rapamycin Supplementation May Ameliorate Erectile Function in Rats With Streptozotocin-Induced Type 1 Diabetes by Inducing Autophagy and Inhibiting Apoptosis, Endothelial Dysfunction, and Corporal Fibrosis.
Lin H, Wang T, Ruan Y, Liu K, Li H, Wang S, Li M, Liu J
The journal of sexual medicine 2018 Sep;15(9):1246-1259
The journal of sexual medicine 2018 Sep;15(9):1246-1259
Effects of Guanfu total base on Bcl-2 and Bax expression and correlation with atrial fibrillation.
Li Y, Song B, Xu C
Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese 2018 Sep-Oct;59(5):274-278
Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese 2018 Sep-Oct;59(5):274-278
Rapid induction of apoptosis in tumor cells treated with a new platinum(II) complex based on amino-thiazolidinone.
Song XQ, Liu YH, Shao J, Zhang ZL, Xie CZ, Qiao X, Bao WG, Xu JY
European journal of medicinal chemistry 2018 Sep 5;157:188-197
European journal of medicinal chemistry 2018 Sep 5;157:188-197
Different sulfonylureas induce the apoptosis of proximal tubular epithelial cell differently via closing K(ATP) channel.
Zhang R, Zhou X, Shen X, Xie T, Xu C, Zou Z, Dong J, Liao L
Molecular medicine (Cambridge, Mass.) 2018 Sep 4;24(1):47
Molecular medicine (Cambridge, Mass.) 2018 Sep 4;24(1):47
LP1 from Lentinula edodes C(91-3) Induces Autophagy, Apoptosis and Reduces Metastasis in Human Gastric Cancer Cell Line SGC-7901.
Batool S, Joseph TP, Hussain M, Vuai MS, Khinsar KH, Din SRU, Padhiar AA, Zhong M, Ning A, Zhang W, Cao J, Huang M
International journal of molecular sciences 2018 Sep 30;19(10)
International journal of molecular sciences 2018 Sep 30;19(10)
Tumor-targeting core-shell structured nanoparticles for drug procedural controlled release and cancer sonodynamic combined therapy.
Wang L, Hu Y, Hao Y, Li L, Zheng C, Zhao H, Niu M, Yin Y, Zhang Z, Zhang Y
Journal of controlled release : official journal of the Controlled Release Society 2018 Sep 28;286:74-84
Journal of controlled release : official journal of the Controlled Release Society 2018 Sep 28;286:74-84
Anti-breast-Cancer Activity Exerted by β-Sitosterol-d-glucoside from Sweet Potato via Upregulation of MicroRNA-10a and via the PI3K-Akt Signaling Pathway.
Xu H, Li Y, Han B, Li Z, Wang B, Jiang P, Zhang J, Ma W, Zhou D, Li X, Ye X
Journal of agricultural and food chemistry 2018 Sep 19;66(37):9704-9718
Journal of agricultural and food chemistry 2018 Sep 19;66(37):9704-9718
Selenoprotein S protects against adipocyte death through mediation of the IRE1α-sXBP1 pathway.
Men L, Yu S, Yao J, Li Y, Ren D, Du J
Biochemical and biophysical research communications 2018 Sep 18;503(4):2866-2871
Biochemical and biophysical research communications 2018 Sep 18;503(4):2866-2871
ABT-199-mediated inhibition of Bcl-2 as a potential therapeutic strategy for nasopharyngeal carcinoma.
Wang Y, Wang Y, Fan X, Song J, Wu H, Han J, Lu L, Weng X, Nie G
Biochemical and biophysical research communications 2018 Sep 10;503(3):1214-1220
Biochemical and biophysical research communications 2018 Sep 10;503(3):1214-1220
Concurrence of autophagy with apoptosis in alveolar epithelial cells contributes to chronic pulmonary toxicity induced by methamphetamine.
Wang Y, Gu YH, Liang LY, Liu M, Jiang B, Zhu MJ, Wang X, Shi L
Cell proliferation 2018 Oct;51(5):e12476
Cell proliferation 2018 Oct;51(5):e12476
Zinc enhances chemosensitivity to paclitaxel in PC‑3 prostate cancer cells.
Zhang P, Li Y, Tang X, Guo R, Li J, Chen YY, Guo H, Su J, Sun L, Liu Y
Oncology reports 2018 Oct;40(4):2269-2277
Oncology reports 2018 Oct;40(4):2269-2277
Probiotics decrease depressive behaviors induced by constipation via activating the AKT signaling pathway.
Xu N, Fan W, Zhou X, Liu Y, Ma P, Qi S, Gu B
Metabolic brain disease 2018 Oct;33(5):1625-1633
Metabolic brain disease 2018 Oct;33(5):1625-1633
Dual effects of baicalin on osteoclast differentiation and bone resorption.
Lu X, He W, Yang W, Li J, Han W, Liu Q, Zhang T, Jiang J, Qin A, Qian Y
Journal of cellular and molecular medicine 2018 Oct;22(10):5029-5039
Journal of cellular and molecular medicine 2018 Oct;22(10):5029-5039
β-Bourbonene attenuates proliferation and induces apoptosis of prostate cancer cells.
Wang Z, Liu F, Yu JJ, Jin JZ
Oncology letters 2018 Oct;16(4):4519-4525
Oncology letters 2018 Oct;16(4):4519-4525
Effects of zerumbone on proliferation and apoptosis of esophageal cancer cells and on P53 and Bcl-2 expression levels.
Ma S, Lei Y, Zhang L, Wang J
Oncology letters 2018 Oct;16(4):4379-4383
Oncology letters 2018 Oct;16(4):4379-4383
Eugenol protects the transplanted heart against ischemia/reperfusion injury in rats by inhibiting the inflammatory response and apoptosis.
Feng W, Jin L, Xie Q, Huang L, Jiang Z, Ji Y, Li C, Yang L, Wang D
Experimental and therapeutic medicine 2018 Oct;16(4):3464-3470
Experimental and therapeutic medicine 2018 Oct;16(4):3464-3470
Layer-by-layer assembled gold nanoshells for the intracellular delivery of miR-34a.
Goyal R, Kapadia CH, Melamed JR, Riley RS, Day ES
Cellular and molecular bioengineering 2018 Oct;11(5):383-396
Cellular and molecular bioengineering 2018 Oct;11(5):383-396
Low-Dose Radiation Enhanced Inhibition of Breast Tumor Xenograft and Reduced Myocardial Injury Induced by Doxorubicin.
Jiang X, Du Y, Meng X, Zhang H, Zhao D, Zhao L, Chen J, Xiao S, Jiang H
Dose-response : a publication of International Hormesis Society 2018 Oct-Dec;16(4):1559325818813061
Dose-response : a publication of International Hormesis Society 2018 Oct-Dec;16(4):1559325818813061
Newcastle disease virus V protein inhibits apoptosis in DF-1 cells by downregulating TXNL1.
Wang C, Chu Z, Liu W, Pang Y, Gao X, Tang Q, Ma J, Lu K, Adam FEA, Dang R, Xiao S, Wang X, Yang Z
Veterinary research 2018 Oct 5;49(1):102
Veterinary research 2018 Oct 5;49(1):102
Nucleus pulposus cell apoptosis is attenuated by CDMP-2 through regulating oxidative damage under the hyperosmotic environment.
Jiao S, Li J, Liu B, Yang M, Xiu J, Qu D
Bioscience reports 2018 Oct 31;38(5)
Bioscience reports 2018 Oct 31;38(5)
Disruption of Chromosomal Architecture of cox2 Locus Sensitizes Lung Cancer Cells to Radiotherapy.
Sun Y, Dai H, Chen S, Zhang Y, Wu T, Cao X, Zhao G, Xu A, Wang J, Wu L
Molecular therapy : the journal of the American Society of Gene Therapy 2018 Oct 3;26(10):2456-2465
Molecular therapy : the journal of the American Society of Gene Therapy 2018 Oct 3;26(10):2456-2465
Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway.
Peng Y, Wang Y, Tang N, Sun D, Lan Y, Yu Z, Zhao X, Feng L, Zhang B, Jin L, Yu F, Ma X, Lv C
Journal of experimental & clinical cancer research : CR 2018 Oct 12;37(1):248
Journal of experimental & clinical cancer research : CR 2018 Oct 12;37(1):248
Sestrin 2 confers primary resistance to sorafenib by simultaneously activating AKT and AMPK in hepatocellular carcinoma.
Dai J, Huang Q, Niu K, Wang B, Li Y, Dai C, Chen Z, Tao K, Dai J
Cancer medicine 2018 Nov;7(11):5691-5703
Cancer medicine 2018 Nov;7(11):5691-5703
BF211, a derivative of bufalin, enhances the cytocidal effects in multiple myeloma cells by inhibiting the IL-6/JAK2/STAT3 pathway.
Wu XY, Tian F, Su MH, Wu M, Huang Y, Hu LH, Jin L, Zhu XJ
International immunopharmacology 2018 Nov;64:24-32
International immunopharmacology 2018 Nov;64:24-32
RNA interference of long noncoding RNA HOTAIR suppresses autophagy and promotes apoptosis and sensitivity to cisplatin in oral squamous cell carcinoma.
Wang X, Liu W, Wang P, Li S
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2018 Nov;47(10):930-937
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2018 Nov;47(10):930-937
HMGB1 knock-down promoting tumor cells viability and arrest pro-apoptotic proteins via Stat3/NFκB in HepG2 cells.
Alduais S, Alduais Y, Wu X, Li H, Mao J
BioFactors (Oxford, England) 2018 Nov;44(6):570-576
BioFactors (Oxford, England) 2018 Nov;44(6):570-576
3‑Bromopyruvate sensitizes human breast cancer cells to TRAIL‑induced apoptosis via the phosphorylated AMPK‑mediated upregulation of DR5.
Chen Y, Wei L, Zhang X, Liu X, Chen Y, Zhang S, Zhou L, Li Q, Pan Q, Zhao S, Liu H
Oncology reports 2018 Nov;40(5):2435-2444
Oncology reports 2018 Nov;40(5):2435-2444
Excessive apoptosis and disordered autophagy flux contribute to the neurotoxicity induced by high iodine in Sprague-Dawley rat.
Cui Y, Zhang Z, Zhang B, Zhao L, Hou C, Zeng Q, Nie J, Yu J, Zhao Y, Gao T, Wang A, Liu H
Toxicology letters 2018 Nov;297:24-33
Toxicology letters 2018 Nov;297:24-33
Cantharidin inhibits melanoma cell proliferation via the miR‑21‑mediated PTEN pathway.
Mu Z, Sun Q
Molecular medicine reports 2018 Nov;18(5):4603-4610
Molecular medicine reports 2018 Nov;18(5):4603-4610
Aclidinium inhibits proliferation and metastasis of ovarian cancer SKOV3 cells via downregulating PI3K/AKT/mTOR signaling pathway.
Qiao J, Wang WJ, Zhang Y
Oncology letters 2018 Nov;16(5):6417-6422
Oncology letters 2018 Nov;16(5):6417-6422
Isoliquiritigenin inhibits cell proliferation and migration through the PI3K/AKT signaling pathway in A549 lung cancer cells.
Tian T, Sun J, Wang J, Liu Y, Liu H
Oncology letters 2018 Nov;16(5):6133-6139
Oncology letters 2018 Nov;16(5):6133-6139
DNMTs inhibitor SGI-1027 induces apoptosis in Huh7 human hepatocellular carcinoma cells.
Sun N, Zhang J, Zhang C, Zhao B, Jiao A
Oncology letters 2018 Nov;16(5):5799-5806
Oncology letters 2018 Nov;16(5):5799-5806
UNBS5162 induces growth inhibition and apoptosis via inhibiting PI3K/AKT/mTOR pathway in triple negative breast cancer MDA-MB-231 cells.
Yue X, Li M, Chen D, Xu Z, Sun S
Experimental and therapeutic medicine 2018 Nov;16(5):3921-3928
Experimental and therapeutic medicine 2018 Nov;16(5):3921-3928
Activation of α7 nicotinic acetylcholine receptor alleviates Aβ(1-42)-induced neurotoxicity via downregulation of p38 and JNK MAPK signaling pathways.
Chang KW, Zong HF, Ma KG, Zhai WY, Yang WN, Hu XD, Xu JH, Chen XL, Ji SF, Qian YH
Neurochemistry international 2018 Nov;120:238-250
Neurochemistry international 2018 Nov;120:238-250
The relationship between lncRNA PCGEM1 and STAT3 during the occurrence and development of endometrial carcinoma.
Li Q, Shen F, Zhao L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Nov;107:918-928
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Nov;107:918-928
Abnormally elevated USP37 expression in breast cancer stem cells regulates stemness, epithelial-mesenchymal transition and cisplatin sensitivity.
Qin T, Li B, Feng X, Fan S, Liu L, Liu D, Mao J, Lu Y, Yang J, Yu X, Zhang Q, Zhang J, Song B, Li M, Li L
Journal of experimental & clinical cancer research : CR 2018 Nov 27;37(1):287
Journal of experimental & clinical cancer research : CR 2018 Nov 27;37(1):287
Chloroquine ameliorates carbon tetrachloride-induced acute liver injury in mice via the concomitant inhibition of inflammation and induction of apoptosis.
Dai C, Xiao X, Li D, Tun S, Wang Y, Velkov T, Tang S
Cell death & disease 2018 Nov 26;9(12):1164
Cell death & disease 2018 Nov 26;9(12):1164
An E-selectin targeting and MMP-2-responsive dextran-curcumin polymeric prodrug for targeted therapy of acute kidney injury.
Hu JB, Liu D, Qi J, Lu KJ, Jin FY, Ying XY, You J, Du YZ
Biomaterials science 2018 Nov 20;6(12):3397-3409
Biomaterials science 2018 Nov 20;6(12):3397-3409
Ginsenoside Rg5 induces apoptosis and autophagy via the inhibition of the PI3K/Akt pathway against breast cancer in a mouse model.
Liu Y, Fan D
Food & function 2018 Nov 14;9(11):5513-5527
Food & function 2018 Nov 14;9(11):5513-5527
Alisol B-23-acetate, a tetracyclic triterpenoid isolated from Alisma orientale, induces apoptosis in human lung cancer cells via the mitochondrial pathway.
Wang J, Li H, Wang X, Shen T, Wang S, Ren D
Biochemical and biophysical research communications 2018 Nov 10;505(4):1015-1021
Biochemical and biophysical research communications 2018 Nov 10;505(4):1015-1021
Effects and mechanism of amyloid β1-42 on mitochondria in astrocytes.
Yao Y, Huang JZ, Chen Y, Hu HJ, Tang X, Li X
Molecular medicine reports 2018 May;17(5):6997-7004
Molecular medicine reports 2018 May;17(5):6997-7004
Cantharidin suppresses cell growth and migration, and activates autophagy in human non-small cell lung cancer cells.
Liu YP, Li L, Xu L, Dai EN, Chen WD
Oncology letters 2018 May;15(5):6527-6532
Oncology letters 2018 May;15(5):6527-6532
Lenalidomide improvement of cisplatin antitumor efficacy on triple-negative breast cancer cells in vitro.
Yin LL, Wen XM, Lai QH, Li J, Wang XW
Oncology letters 2018 May;15(5):6469-6474
Oncology letters 2018 May;15(5):6469-6474
Cardioprotection of CAPE-oNO(2) against myocardial ischemia/reperfusion induced ROS generation via regulating the SIRT1/eNOS/NF-κB pathway in vivo and in vitro.
Li D, Wang X, Huang Q, Li S, Zhou Y, Li Z
Redox biology 2018 May;15:62-73
Redox biology 2018 May;15:62-73
After Treatment with Methylene Blue is Effective against Delayed Encephalopathy after Acute Carbon Monoxide Poisoning.
Zhao N, Liang P, Zhuo X, Su C, Zong X, Guo B, Han D, Yan X, Hu S, Zhang Q, Tie X
Basic & clinical pharmacology & toxicology 2018 May;122(5):470-480
Basic & clinical pharmacology & toxicology 2018 May;122(5):470-480
Diallyl Trisulfide inhibits breast cancer stem cells via suppression of Wnt/β-catenin pathway.
Li X, Meng Y, Xie C, Zhu J, Wang X, Li Y, Geng S, Wu J, Zhong C, Li M
Journal of cellular biochemistry 2018 May;119(5):4134-4141
Journal of cellular biochemistry 2018 May;119(5):4134-4141
Matrine reversed multidrug resistance of breast cancer MCF-7/ADR cells through PI3K/AKT signaling pathway.
Zhou BG, Wei CS, Zhang S, Zhang Z, Gao HM
Journal of cellular biochemistry 2018 May;119(5):3885-3891
Journal of cellular biochemistry 2018 May;119(5):3885-3891
The NK1 receptor antagonist NKP608 inhibits proliferation of human colorectal cancer cells via Wnt signaling pathway.
Niu XL, Hou JF, Li JX
Biological research 2018 May 30;51(1):14
Biological research 2018 May 30;51(1):14
The molecular landscape of synchronous colorectal cancer reveals genetic heterogeneity.
Wang X, Fang H, Cheng Y, Li L, Sun X, Fu T, Huang P, Zhang A, Feng Z, Li C, Huang X, Li G, Du P, Yang H, Fang X, Li F, Gao Q, Liu B
Carcinogenesis 2018 May 3;39(5):708-718
Carcinogenesis 2018 May 3;39(5):708-718
Betulinic acid chemosensitizes breast cancer by triggering ER stress-mediated apoptosis by directly targeting GRP78.
Cai Y, Zheng Y, Gu J, Wang S, Wang N, Yang B, Zhang F, Wang D, Fu W, Wang Z
Cell death & disease 2018 May 25;9(6):636
Cell death & disease 2018 May 25;9(6):636
Procyanidin from peanut skin induces antiproliferative effect in human prostate carcinoma cells DU145.
Chen L, Yan F, Chen W, Zhao L, Zhang J, Lu Q, Liu R
Chemico-biological interactions 2018 May 25;288:12-23
Chemico-biological interactions 2018 May 25;288:12-23
MicroRNA-1247 inhibits cell proliferation by directly targeting ZNF346 in childhood neuroblastoma.
Wu T, Lin Y, Xie Z
Biological research 2018 May 24;51(1):13
Biological research 2018 May 24;51(1):13
Neuroprotective effect of phosphocreatine on oxidative stress and mitochondrial dysfunction induced apoptosis in vitro and in vivo: Involvement of dual PI3K/Akt and Nrf2/HO-1 pathways.
Li H, Tang Z, Chu P, Song Y, Yang Y, Sun B, Niu M, Qaed E, Shopit A, Han G, Ma X, Peng J, Hu M, Tang Z
Free radical biology & medicine 2018 May 20;120:228-238
Free radical biology & medicine 2018 May 20;120:228-238
PEST-containing nuclear protein mediates the proliferation, migration, and invasion of human neuroblastoma cells through MAPK and PI3K/AKT/mTOR signaling pathways.
Wu DD, Gao YR, Li T, Wang DY, Lu D, Liu SY, Hong Y, Ning HB, Liu JP, Shang J, Shi JF, Wei JS, Ji XY
BMC cancer 2018 May 2;18(1):499
BMC cancer 2018 May 2;18(1):499
Rat Model of Brain Injury to Occupants of Vehicles Targeted by Land Mines: Mitigation by Elastomeric Frame Designs.
Tchantchou F, Puche AA, Leiste U, Fourney W, Blanpied TA, Fiskum G
Journal of neurotrauma 2018 May 15;35(10):1192-1203
Journal of neurotrauma 2018 May 15;35(10):1192-1203
Fluoride induces apoptosis via inhibiting SIRT1 activity to activate mitochondrial p53 pathway in human neuroblastoma SH-SY5Y cells.
Tu W, Zhang Q, Liu Y, Han L, Wang Q, Chen P, Zhang S, Wang A, Zhou X
Toxicology and applied pharmacology 2018 May 15;347:60-69
Toxicology and applied pharmacology 2018 May 15;347:60-69
Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice.
Jia YN, Lu HP, Peng YL, Zhang BS, Gong XB, Su J, Zhou Y, Pan MH, Xu L
International immunopharmacology 2018 Mar;56:105-112
International immunopharmacology 2018 Mar;56:105-112
Donor Treatment With a Hypoxia-Inducible Factor-1 Agonist Prevents Donation After Cardiac Death Liver Graft Injury in a Rat Isolated Perfusion Model.
Zhang X, Liu Z, Xiao Q, Zeng C, Lai CH, Fan X, Ye Q, Wang Y, Xiong Y
Artificial organs 2018 Mar;42(3):280-289
Artificial organs 2018 Mar;42(3):280-289
Bcl-2 overexpression reduces cisplatin cytotoxicity by decreasing ER-mitochondrial Ca2+ signaling in SKOV3 cells.
Xu L, Xie Q, Qi L, Wang C, Xu N, Liu W, Yu Y, Li S, Xu Y
Oncology reports 2018 Mar;39(3):985-992
Oncology reports 2018 Mar;39(3):985-992
Capsaicin enhances the antitumor activity of sorafenib in hepatocellular carcinoma cells and mouse xenograft tumors through increased ERK signaling.
Zhang SS, Ni YH, Zhao CR, Qiao Z, Yu HX, Wang LY, Sun JY, Du C, Zhang JH, Dong LY, Wang K, Gao JJ
Acta pharmacologica Sinica 2018 Mar;39(3):438-448
Acta pharmacologica Sinica 2018 Mar;39(3):438-448
MicroRNA-124a inhibits cell proliferation and migration in liver cancer by regulating interleukin-11.
Yu L, Wang S, Lin X, Lu Y, Gu P
Molecular medicine reports 2018 Mar;17(3):3972-3978
Molecular medicine reports 2018 Mar;17(3):3972-3978
Overexpression of Nitrogen Permease Regulator Like-2 (NPRL2) Enhances Sensitivity to Irinotecan (CPT-11) in Colon Cancer Cells by Activating the DNA Damage Checkpoint Pathway.
Liu S, Liu B
Medical science monitor : international medical journal of experimental and clinical research 2018 Mar 9;24:1424-1433
Medical science monitor : international medical journal of experimental and clinical research 2018 Mar 9;24:1424-1433
7-Acetylsinumaximol B Induces Apoptosis and Autophagy in Human Gastric Carcinoma Cells through Mitochondria Dysfunction and Activation of the PERK/eIF2α/ATF4/CHOP Signaling Pathway.
Tsai TC, Lai KH, Su JH, Wu YJ, Sheu JH
Marine drugs 2018 Mar 26;16(4)
Marine drugs 2018 Mar 26;16(4)
New Drug Candidate Targeting the 4A1 Orphan Nuclear Receptor for Medullary Thyroid Cancer Therapy.
Zhang L, Liu W, Wang Q, Li Q, Wang H, Wang J, Teng T, Chen M, Ji A, Li Y
Molecules (Basel, Switzerland) 2018 Mar 2;23(3)
Molecules (Basel, Switzerland) 2018 Mar 2;23(3)
Epidermal Growth Factor, through Alleviating Oxidative Stress, Protect IPEC-J2 Cells from Lipopolysaccharides-Induced Apoptosis.
Tang X, Liu B, Wang X, Yu Q, Fang R
International journal of molecular sciences 2018 Mar 14;19(3)
International journal of molecular sciences 2018 Mar 14;19(3)
Wnt/β-catenin signaling mediates the suppressive effects of diallyl trisulfide on colorectal cancer stem cells.
Zhang Q, Li XT, Chen Y, Chen JQ, Zhu JY, Meng Y, Wang XQ, Li Y, Geng SS, Xie CF, Wu JS, Zhong CY, Han HY
Cancer chemotherapy and pharmacology 2018 Jun;81(6):969-977
Cancer chemotherapy and pharmacology 2018 Jun;81(6):969-977
Luteoloside attenuates anoxia/reoxygenation-induced cardiomyocytes injury via mitochondrial pathway mediated by 14-3-3η protein.
Liu Z, Yang L, Huang J, Xu P, Zhang Z, Yin D, Liu J, He H, He M
Phytotherapy research : PTR 2018 Jun;32(6):1126-1134
Phytotherapy research : PTR 2018 Jun;32(6):1126-1134
Osteopontin is essential for IL-1β production and apoptosis in peri-implantitis.
Che C, Liu J, Yang J, Ma L, Bai N, Zhang Q
Clinical implant dentistry and related research 2018 Jun;20(3):384-392
Clinical implant dentistry and related research 2018 Jun;20(3):384-392
Cognitive-enhancing effect of polysaccharides from Flammulina velutipes on Alzheimer's disease by compatibilizing with ginsenosides.
Zhang Y, Li H, Yang X, Jin G, Zhang Y
International journal of biological macromolecules 2018 Jun;112:788-795
International journal of biological macromolecules 2018 Jun;112:788-795
Osthole inhibits the PI3K/AKT signaling pathway via activation of PTEN and induces cell cycle arrest and apoptosis in esophageal squamous cell carcinoma.
Zhu X, Li Z, Li T, Long F, Lv Y, Liu L, Liu X, Zhan Q
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jun;102:502-509
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jun;102:502-509
CD300A promotes tumor progression by PECAM1, ADCY7 and AKT pathway in acute myeloid leukemia.
Sun X, Huang S, Wang X, Zhang X, Wang X
Oncotarget 2018 Jun 8;9(44):27574-27584
Oncotarget 2018 Jun 8;9(44):27574-27584
Curcumin-Loaded Solid Lipid Nanoparticles Enhanced Anticancer Efficiency in Breast Cancer.
Wang W, Chen T, Xu H, Ren B, Cheng X, Qi R, Liu H, Wang Y, Yan L, Chen S, Yang Q, Chen C
Molecules (Basel, Switzerland) 2018 Jun 29;23(7)
Molecules (Basel, Switzerland) 2018 Jun 29;23(7)
Design, synthesis and biological evaluation of N-phenyl-(2,4-dihydroxypyrimidine-5-sulfonamido)benzoyl hydrazide derivatives as thymidylate synthase (TS) inhibitors and as potential antitumor drugs.
Li XY, Liang JW, Mohamed O K, Zhang TJ, Lu GQ, Meng FH
European journal of medicinal chemistry 2018 Jun 25;154:267-279
European journal of medicinal chemistry 2018 Jun 25;154:267-279
Role of Daucosterol Linoleate on Breast Cancer: Studies on Apoptosis and Metastasis.
Han B, Jiang P, Liu W, Xu H, Li Y, Li Z, Ma H, Yu Y, Li X, Ye X
Journal of agricultural and food chemistry 2018 Jun 20;66(24):6031-6041
Journal of agricultural and food chemistry 2018 Jun 20;66(24):6031-6041
PGC1α promotes cisplatin resistance in human ovarian carcinoma cells through upregulation of mitochondrial biogenesis.
Shen L, Sun B, Sheng J, Yu S, Li Y, Xu H, Su J, Sun L
International journal of oncology 2018 Jul;53(1):404-416
International journal of oncology 2018 Jul;53(1):404-416
miRNA‑222 promotes liver cancer cell proliferation, migration and invasion and inhibits apoptosis by targeting BBC3.
Liu Z, Sun J, Liu B, Zhao M, Xing E, Dang C
International journal of molecular medicine 2018 Jul;42(1):141-148
International journal of molecular medicine 2018 Jul;42(1):141-148
Isorhamnetin: A hepatoprotective flavonoid inhibits apoptosis and autophagy via P38/PPAR-α pathway in mice.
Lu X, Liu T, Chen K, Xia Y, Dai W, Xu S, Xu L, Wang F, Wu L, Li J, Li S, Wang W, Yu Q, Feng J, Fan X, Zhou Y, Niu P, Guo C
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jul;103:800-811
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jul;103:800-811
Coptisine from Rhizoma coptidis exerts an anti-cancer effect on hepatocellular carcinoma by up-regulating miR-122.
Chai FN, Ma WY, Zhang J, Xu HS, Li YF, Zhou QD, Li XG, Ye XL
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jul;103:1002-1011
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jul;103:1002-1011
Self-assembled RNAi nanoflowers via rolling circle transcription for aptamer-targeted siRNA delivery.
Cheng H, Hong S, Wang Z, Sun N, Wang T, Zhang Y, Chen H, Pei R
Journal of materials chemistry. B 2018 Jul 28;6(28):4638-4644
Journal of materials chemistry. B 2018 Jul 28;6(28):4638-4644
CART peptide activates the Nrf2/HO-1 antioxidant pathway and protects hippocampal neurons in a rat model of Alzheimer's disease.
Jiao W, Wang Y, Kong L, Ou-Yang T, Meng Q, Fu Q, Hu Z
Biochemical and biophysical research communications 2018 Jul 2;501(4):1016-1022
Biochemical and biophysical research communications 2018 Jul 2;501(4):1016-1022
Formononetin, an isoflavone from Astragalus membranaceus inhibits proliferation and metastasis of ovarian cancer cells.
Zhang J, Liu L, Wang J, Ren B, Zhang L, Li W
Journal of ethnopharmacology 2018 Jul 15;221:91-99
Journal of ethnopharmacology 2018 Jul 15;221:91-99
Damage to the myogenic differentiation of C2C12 cells by heat stress is associated with up-regulation of several selenoproteins.
Tang J, He A, Yan H, Jia G, Liu G, Chen X, Cai J, Tian G, Shang H, Zhao H
Scientific reports 2018 Jul 13;8(1):10601
Scientific reports 2018 Jul 13;8(1):10601
Cisplatin and curcumin co-loaded nano-liposomes for the treatment of hepatocellular carcinoma.
Cheng Y, Zhao P, Wu S, Yang T, Chen Y, Zhang X, He C, Zheng C, Li K, Ma X, Xiang G
International journal of pharmaceutics 2018 Jul 10;545(1-2):261-273
International journal of pharmaceutics 2018 Jul 10;545(1-2):261-273
UNBS5162 inhibits the proliferation of human A549 non-small-cell lung cancer cells by promoting apoptosis.
Liu C, Xing J, Gao Y
Thoracic cancer 2018 Jan;9(1):105-111
Thoracic cancer 2018 Jan;9(1):105-111
Anticancer effect of SZC015 on pancreatic cancer via mitochondria-dependent apoptosis and the constitutive suppression of activated nuclear factor κB and STAT3 in vitro and in vivo.
Song Y, Gao L, Tang Z, Li H, Sun B, Chu P, Qaed E, Ma X, Peng J, Wang S, Hu M, Tang Z
Journal of cellular physiology 2018 Jan;234(1):777-788
Journal of cellular physiology 2018 Jan;234(1):777-788
Protective Effect of Selenoprotein X Against Oxidative Stress-Induced Cell Apoptosis in Human Hepatocyte (LO2) Cells via the p38 Pathway.
Tang JY, He AH, Jia G, Liu GM, Chen XL, Cai JY, Shang HY, Liao JQ, Zhao H
Biological trace element research 2018 Jan;181(1):44-53
Biological trace element research 2018 Jan;181(1):44-53
Downregulation of TRIM28 inhibits growth and increases apoptosis of nude mice with non‑small cell lung cancer xenografts.
Liu L, Zhang L, Wang J, Zhao X, Xu Q, Lu Y, Zuo Y, Chen L, Du J, Lian Y, Zhang Q
Molecular medicine reports 2018 Jan;17(1):835-842
Molecular medicine reports 2018 Jan;17(1):835-842
UNBS5162 inhibits the proliferation of esophageal cancer squamous cells via the PI3K/AKT signaling pathway.
He D, Zhang S
Molecular medicine reports 2018 Jan;17(1):549-555
Molecular medicine reports 2018 Jan;17(1):549-555
Molecular mechanisms of Ellis‑van Creveld gene variations in ventricular septal defect.
Liu F, Liu X, Xu Z, Yuan P, Zhou Q, Jin J, Yan X, Xu Z, Cao Q, Yu J, Cheng Y, Wan R, Hong K
Molecular medicine reports 2018 Jan;17(1):1527-1536
Molecular medicine reports 2018 Jan;17(1):1527-1536
Pseudolaric acid B induced autophagy, but not apoptosis, in MRC5 human fibroblast cells.
Wang Y, Gao H, Wu T, Wang Z, Song F, Chen A, Zhang J, Zhang W, Zhang H, Yu J
Oncology letters 2018 Jan;15(1):863-870
Oncology letters 2018 Jan;15(1):863-870
The inhibitory effects of soybean isoflavones on testicular cell apoptosis in mice with type 2 diabetes.
Du Z, Qiu Z, Wang Z, Wang X
Experimental and therapeutic medicine 2018 Jan;15(1):305-309
Experimental and therapeutic medicine 2018 Jan;15(1):305-309
Experimental evidence of good efficacy and reduced toxicity with peptide-doxorubicin to treat gastric cancer.
Zhang J, Yuan JP, Wang Q, Shao LH, Liu SP, Firestone RA, Hong YP, Li JG, Xin YC, Li Y
Oncotarget 2018 Jan 5;9(2):1957-1968
Oncotarget 2018 Jan 5;9(2):1957-1968
Increased high mobility group A 2 expression promotes transition of cervical intraepithelial neoplasm into cervical cancer.
Wang L, Shen H, Zhu D, Feng B, Yu L, Tian X, Ren C, Gao C, Li X, Ma D, Hu Z, Wang H
Oncotarget 2018 Jan 30;9(8):7891-7901
Oncotarget 2018 Jan 30;9(8):7891-7901
Propranolol enhanced the anti-tumor effect of sunitinib by inhibiting proliferation and inducing G0/G1/S phase arrest in malignant melanoma.
Kuang X, Qi M, Peng C, Zhou C, Su J, Zeng W, Liu H, Zhang J, Chen M, Shen M, Xie X, Li F, Zhao S, Li Q, Luo Z, Chen J, Tao J, He Y, Chen X
Oncotarget 2018 Jan 2;9(1):802-811
Oncotarget 2018 Jan 2;9(1):802-811
Capsaicin prevents mitochondrial damage, protects cardiomyocytes subjected to anoxia/reoxygenation injury mediated by 14-3-3η/Bcl-2.
Huang J, Liu Z, Xu P, Zhang Z, Yin D, Liu J, He H, He M
European journal of pharmacology 2018 Jan 15;819:43-50
European journal of pharmacology 2018 Jan 15;819:43-50
Vascular peroxidase 1 mediates hypoxia-induced pulmonary artery smooth muscle cell proliferation, apoptosis resistance and migration.
You B, Liu Y, Chen J, Huang X, Peng H, Liu Z, Tang Y, Zhang K, Xu Q, Li X, Cheng G, Shi R, Zhang G
Cardiovascular research 2018 Jan 1;114(1):188-199
Cardiovascular research 2018 Jan 1;114(1):188-199
Quantitative proteomics analysis of the role of tetraspanin-8 in the drug resistance of gastric cancer.
Li L, Yang D, Cui D, Li Y, Nie Z, Wang J, Liang L
International journal of oncology 2018 Feb;52(2):473-484
International journal of oncology 2018 Feb;52(2):473-484
TAT‑fused IP3R‑derived peptide enhances cisplatin sensitivity of ovarian cancer cells by increasing ER Ca2+ release.
Xie Q, Xu Y, Gao W, Zhang Y, Su J, Liu Y, Guo Y, Dou M, Hu K, Sun L
International journal of molecular medicine 2018 Feb;41(2):809-817
International journal of molecular medicine 2018 Feb;41(2):809-817
6-Hydroxydopamine induces autophagic flux dysfunction by impairing transcription factor EB activation and lysosomal function in dopaminergic neurons and SH-SY5Y cells.
He X, Yuan W, Li Z, Hou Y, Liu F, Feng J
Toxicology letters 2018 Feb;283:58-68
Toxicology letters 2018 Feb;283:58-68
The environmental pollutant BDE-209 regulates NO/cGMP signaling through activation of NMDA receptors in neurons.
Chen J, Li X, Li X, Chen D
Environmental science and pollution research international 2018 Feb;25(4):3397-3407
Environmental science and pollution research international 2018 Feb;25(4):3397-3407
Propofol protects against endotoxin-induced myocardial injury by inhibiting NF-κB-mediated inflammation.
Yang Z, Cheng F, Yan G, Xiong L, Liu H
Experimental and therapeutic medicine 2018 Feb;15(2):2032-2036
Experimental and therapeutic medicine 2018 Feb;15(2):2032-2036
Targeting PI3K, mTOR, ERK, and Bcl-2 signaling network shows superior antileukemic activity against AML ex vivo.
Su Y, Li X, Ma J, Zhao J, Liu S, Wang G, Edwards H, Taub JW, Lin H, Ge Y
Biochemical pharmacology 2018 Feb;148:13-26
Biochemical pharmacology 2018 Feb;148:13-26
Ginsenoside Rg3 sensitizes hypoxic lung cancer cells to cisplatin via blocking of NF-κB mediated epithelial-mesenchymal transition and stemness.
Wang J, Tian L, Khan MN, Zhang L, Chen Q, Zhao Y, Yan Q, Fu L, Liu J
Cancer letters 2018 Feb 28;415:73-85
Cancer letters 2018 Feb 28;415:73-85
PUM1 promotes ovarian cancer proliferation, migration and invasion.
Guan X, Chen S, Liu Y, Wang LL, Zhao Y, Zong ZH
Biochemical and biophysical research communications 2018 Feb 26;497(1):313-318
Biochemical and biophysical research communications 2018 Feb 26;497(1):313-318
Synergistic neuroprotective effect of rasagiline and idebenone against retinal ischemia-reperfusion injury via the Lin28-let-7-Dicer pathway.
Lei D, Shao Z, Zhou X, Yuan H
Oncotarget 2018 Feb 23;9(15):12137-12153
Oncotarget 2018 Feb 23;9(15):12137-12153
Lentivirus-mediated down-regulation of CK2α inhibits proliferation and induces apoptosis of malignant lymphoma and leukemia cells.
Jiang L, Zhang J, Hu N, Liu A, Zhu H, Li L, Tian Y, Chen X, Quan L
Biochemistry and cell biology = Biochimie et biologie cellulaire 2018 Dec;96(6):786-796
Biochemistry and cell biology = Biochimie et biologie cellulaire 2018 Dec;96(6):786-796
Effect of sorghum ethyl-acetate extract on benign prostatic hyperplasia induced by testosterone in Sprague-Dawley rats.
Ryu JM, Jang GY, Park D, Woo KS, Kim TM, Jeong HS, Kim DJ
Bioscience, biotechnology, and biochemistry 2018 Dec;82(12):2101-2108
Bioscience, biotechnology, and biochemistry 2018 Dec;82(12):2101-2108
Mild Hypothermia Protects Renal Function in Ischemia-reperfusion Kidney: An Experimental Study in Mice.
Xia Z, Wang W, Xiao Q, Ye Q, Zhang X, Wang Y
Transplantation proceedings 2018 Dec;50(10):3816-3821
Transplantation proceedings 2018 Dec;50(10):3816-3821
Phenethyl isothiocyanate inhibits colorectal cancer stem cells by suppressing Wnt/β-catenin pathway.
Chen Y, Li Y, Wang XQ, Meng Y, Zhang Q, Zhu JY, Chen JQ, Cao WS, Wang XQ, Xie CF, Li XT, Geng SS, Wu JS, Zhong CY, Han HY
Phytotherapy research : PTR 2018 Dec;32(12):2447-2455
Phytotherapy research : PTR 2018 Dec;32(12):2447-2455
Hypolipidemic, Antioxidant, and Antiapoptotic Effects of Polysaccharides Extracted from Reishi Mushroom, Ganoderma lucidum (Leysser: Fr) Karst, in Mice Fed a High-Fat Diet.
Liang Z, Yuan Z, Li G, Fu F, Shan Y
Journal of medicinal food 2018 Dec;21(12):1218-1227
Journal of medicinal food 2018 Dec;21(12):1218-1227
Ginsenoside Rb1 protects against spinal cord ischemia-reperfusion injury in rats by downregulating the Bax/Bcl-2 ratio and caspase-3 and p-Ask-1 levels.
Zhao D, Zhang M, Yuan H, Meng C, Zhang B, Wu H
Experimental and molecular pathology 2018 Dec;105(3):229-235
Experimental and molecular pathology 2018 Dec;105(3):229-235
MLH1 enhances the sensitivity of human endometrial carcinoma cells to cisplatin by activating the MLH1/c-Abl apoptosis signaling pathway.
Li Y, Zhang S, Wang Y, Peng J, Fang F, Yang X
BMC cancer 2018 Dec 29;18(1):1294
BMC cancer 2018 Dec 29;18(1):1294
Anti-tumoral potential of MDA19 in human osteosarcoma via suppressing PI3K/Akt/mTOR signaling pathway.
Liu B, Xu L, Dai EN, Tian JX, Li JM
Bioscience reports 2018 Dec 21;38(6)
Bioscience reports 2018 Dec 21;38(6)
Crotonols A and B, two rare tigliane diterpenoid derivatives against K562 cells from Croton tiglium.
Wang J, Qin L, Zhao B, Cai L, Zhong Z, Liu Y, Zhou X
Organic & biomolecular chemistry 2018 Dec 19;17(1):195-202
Organic & biomolecular chemistry 2018 Dec 19;17(1):195-202
Metformin suppresses growth and adrenocorticotrophic hormone secretion in mouse pituitary corticotroph tumor AtT20 cells.
Jin K, Ruan L, Pu J, Zhong A, Wang F, Tan S, Huang H, Mu J, Yang G
Molecular and cellular endocrinology 2018 Dec 15;478:53-61
Molecular and cellular endocrinology 2018 Dec 15;478:53-61
Synthesis and Discovery Novel Anti-Cancer Stem Cells Compounds Derived from the Natural Triterpenoic Acids.
Liu X, Li B, Zhang Z, Wei Y, Xu Z, Qin S, Liu N, Zhao R, Peng J, Yang G, Qi M, Liu T, Xie M, Liu S, Gao X, Lu C, Zhu L, Long X, Kang H, Sun T, Zhou H, Wei M, Yang G, Yang C
Journal of medicinal chemistry 2018 Dec 13;61(23):10814-10833
Journal of medicinal chemistry 2018 Dec 13;61(23):10814-10833
Transcription Factor FOXO3a Is a Negative Regulator of Cytotoxicity of Fusarium mycotoxin in GES-1 Cells.
Yang Y, Yu S, Liu N, Xu H, Gong Y, Wu Y, Wang P, Su X, Liao Y, De Saeger S, Humpf HU, Wu A
Toxicological sciences : an official journal of the Society of Toxicology 2018 Dec 1;166(2):370-381
Toxicological sciences : an official journal of the Society of Toxicology 2018 Dec 1;166(2):370-381
The tumor suppressor DLC1 inhibits cancer progression and oncogenic autophagy in hepatocellular carcinoma.
Wu HT, Xie CR, Lv J, Qi HQ, Wang F, Zhang S, Fang QL, Wang FQ, Lu YY, Yin ZY
Laboratory investigation; a journal of technical methods and pathology 2018 Aug;98(8):1014-1024
Laboratory investigation; a journal of technical methods and pathology 2018 Aug;98(8):1014-1024
Mitochondrial cytochrome P450 (CYP) 1B1 is responsible for melatonin-induced apoptosis in neural cancer cells.
Yu Z, Tian X, Peng Y, Sun Z, Wang C, Tang N, Li B, Jian Y, Wang W, Huo X, Ma X
Journal of pineal research 2018 Aug;65(1):e12478
Journal of pineal research 2018 Aug;65(1):e12478
Overcoming resistance to mitochondrial apoptosis by BZML-induced mitotic catastrophe is enhanced by inhibition of autophagy in A549/Taxol cells.
Bai Z, Gao M, Xu X, Zhang H, Xu J, Guan Q, Wang Q, Du J, Li Z, Zuo D, Zhang W, Wu Y
Cell proliferation 2018 Aug;51(4):e12450
Cell proliferation 2018 Aug;51(4):e12450
Subthalamic nucleus deep brain stimulation protects neurons by activating autophagy via PP2A inactivation in a rat model of Parkinson's disease.
Du TT, Chen YC, Lu YQ, Meng FG, Yang H, Zhang JG
Experimental neurology 2018 Aug;306:232-242
Experimental neurology 2018 Aug;306:232-242
HuR stabilizes TFAM mRNA in an ATM/p38-dependent manner in ionizing irradiated cancer cells.
Zhang R, Wang J
Cancer science 2018 Aug;109(8):2446-2457
Cancer science 2018 Aug;109(8):2446-2457
NOD2 promotes dopaminergic degeneration regulated by NADPH oxidase 2 in 6-hydroxydopamine model of Parkinson's disease.
Cheng L, Chen L, Wei X, Wang Y, Ren Z, Zeng S, Zhang X, Wen H, Gao C, Liu H
Journal of neuroinflammation 2018 Aug 29;15(1):243
Journal of neuroinflammation 2018 Aug 29;15(1):243
Traditional Chinese Medicine CFF-1 induced cell growth inhibition, autophagy, and apoptosis via inhibiting EGFR-related pathways in prostate cancer.
Wu Z, Zhu Q, Yin Y, Kang D, Cao R, Tian Q, Zhang Y, Lu S, Liu P
Cancer medicine 2018 Apr;7(4):1546-1559
Cancer medicine 2018 Apr;7(4):1546-1559
Hydrogen sulfide attenuates myocardial fibrosis in diabetic rats through the JAK/STAT signaling pathway.
Liu M, Li Y, Liang B, Li Z, Jiang Z, Chu C, Yang J
International journal of molecular medicine 2018 Apr;41(4):1867-1876
International journal of molecular medicine 2018 Apr;41(4):1867-1876
Endoplasmic Reticulum Stress Facilitates the Survival and Proliferation of Nucleus Pulposus Cells in TNF-α Stimulus by Activating Unfolded Protein Response.
Chen L, Liu L, Xie ZY, Wang F, Sinkemani A, Zhang C, Wang XH, Wang K, Hong X, Wu XT
DNA and cell biology 2018 Apr;37(4):347-358
DNA and cell biology 2018 Apr;37(4):347-358
CHOP induces apoptosis by affecting brain iron metabolism in rats with subarachnoid hemorrhage.
Zhao J, Xiang X, Zhang H, Jiang D, Liang Y, Qing W, Liu L, Zhao Q, He Z
Experimental neurology 2018 Apr;302:22-33
Experimental neurology 2018 Apr;302:22-33
Targeting P-glycoprotein and SORCIN: Dihydromyricetin strengthens anti-proliferative efficiency of adriamycin via MAPK/ERK and Ca(2+) -mediated apoptosis pathways in MCF-7/ADR and K562/ADR.
Sun Y, Wang C, Meng Q, Liu Z, Huo X, Sun P, Sun H, Ma X, Peng J, Liu K
Journal of cellular physiology 2018 Apr;233(4):3066-3079
Journal of cellular physiology 2018 Apr;233(4):3066-3079
Telmisartan inhibits NSCLC A549 cell proliferation and migration by regulating the PI3K/AKT signaling pathway.
Zhang S, Wang Y
Oncology letters 2018 Apr;15(4):5859-5864
Oncology letters 2018 Apr;15(4):5859-5864
Apatinib promotes apoptosis of the SMMC-7721 hepatocellular carcinoma cell line via the PI3K/Akt pathway.
Zhang H, Cao Y, Chen Y, Li G, Yu H
Oncology letters 2018 Apr;15(4):5739-5743
Oncology letters 2018 Apr;15(4):5739-5743
Celecoxib enhances sensitivity to chemotherapy drugs of T-cell lymphoma.
Ma M, Yang X, Zhao L, Wang X, Liu L, Jiao W, Wei Y, Shan B
Oncology letters 2018 Apr;15(4):4649-4656
Oncology letters 2018 Apr;15(4):4649-4656
Synergistic effect of receptor-interacting protein 140 and simvastatin on the inhibition of proliferation and survival of hepatocellular carcinoma cells.
Xia K, Zhang P, Hu J, Hou H, Xiong M, Xiong J, Yan N
Oncology letters 2018 Apr;15(4):4344-4350
Oncology letters 2018 Apr;15(4):4344-4350
MCUR1-Mediated Mitochondrial Calcium Signaling Facilitates Cell Survival of Hepatocellular Carcinoma via Reactive Oxygen Species-Dependent P53 Degradation.
Ren T, Wang J, Zhang H, Yuan P, Zhu J, Wu Y, Huang Q, Guo X, Zhang J, Ji L, Li J, Zhang H, Yang H, Xing J
Antioxidants & redox signaling 2018 Apr 20;28(12):1120-1136
Antioxidants & redox signaling 2018 Apr 20;28(12):1120-1136
Rapamycin Confers Neuroprotection against Colistin-Induced Oxidative Stress, Mitochondria Dysfunction, and Apoptosis through the Activation of Autophagy and mTOR/Akt/CREB Signaling Pathways.
Dai C, Ciccotosto GD, Cappai R, Wang Y, Tang S, Hoyer D, Schneider EK, Velkov T, Xiao X
ACS chemical neuroscience 2018 Apr 18;9(4):824-837
ACS chemical neuroscience 2018 Apr 18;9(4):824-837
Long Noncoding RNA LINC01234 Functions as a Competing Endogenous RNA to Regulate CBFB Expression by Sponging miR-204-5p in Gastric Cancer.
Chen X, Chen Z, Yu S, Nie F, Yan S, Ma P, Chen Q, Wei C, Fu H, Xu T, Ren S, Sun M, Wang Z
Clinical cancer research : an official journal of the American Association for Cancer Research 2018 Apr 15;24(8):2002-2014
Clinical cancer research : an official journal of the American Association for Cancer Research 2018 Apr 15;24(8):2002-2014
Astrocytes mediated the nootropic and neurotrophic effects of Sarsasapogenin-AA13 via upregulating brain-derived neurotrophic factor.
Dong D, Mao Y, Huang C, Jiao Q, Pan H, Ma L, Wang R
American journal of translational research 2017;9(9):4015-4025
American journal of translational research 2017;9(9):4015-4025
COX-2 mediates PM2.5-induced apoptosis and inflammation in vascular endothelial cells.
Yin J, Xia W, Li Y, Guo C, Zhang Y, Huang S, Jia Z, Zhang A
American journal of translational research 2017;9(9):3967-3976
American journal of translational research 2017;9(9):3967-3976
RIZ1 negatively regulates ubiquitin-conjugating enzyme E2C/UbcH10 via targeting c-Myc in meningioma.
Cai Z, Zou Y, Hu H, Lu C, Sun W, Jiang L, Hu G
American journal of translational research 2017;9(5):2645-2655
American journal of translational research 2017;9(5):2645-2655
Deletion of diacylglycerol-responsive TRPC genes attenuates diabetic nephropathy by inhibiting activation of the TGFβ1 signaling pathway.
Liu B, He X, Li S, Xu B, Birnbaumer L, Liao Y
American journal of translational research 2017;9(12):5619-5630
American journal of translational research 2017;9(12):5619-5630
Silencing HOXD10 by promoter region hypermethylation activates ERK signaling in hepatocellular carcinoma.
Guo Y, Peng Y, Gao D, Zhang M, Yang W, Linghu E, Herman JG, Fuks F, Dong G, Guo M
Clinical epigenetics 2017;9:116
Clinical epigenetics 2017;9:116
Downregulation of Mitochondrial Single Stranded DNA Binding Protein (SSBP1) Induces Mitochondrial Dysfunction and Increases the Radiosensitivity in Non-Small Cell Lung Cancer Cells.
Wang Y, Hu L, Zhang X, Zhao H, Xu H, Wei Y, Jiang H, Xie C, Zhou Y, Zhou F
Journal of Cancer 2017;8(8):1400-1409
Journal of Cancer 2017;8(8):1400-1409
Santamarine Inhibits NF-кB and STAT3 Activation and Induces Apoptosis in HepG2 Liver Cancer Cells via Oxidative Stress.
Mehmood T, Maryam A, Tian X, Khan M, Ma T
Journal of Cancer 2017;8(18):3707-3717
Journal of Cancer 2017;8(18):3707-3717
Endoplasmic Reticulum Stress Mediates Methamphetamine-Induced Blood-Brain Barrier Damage.
Qie X, Wen D, Guo H, Xu G, Liu S, Shen Q, Liu Y, Zhang W, Cong B, Ma C
Frontiers in pharmacology 2017;8:639
Frontiers in pharmacology 2017;8:639
Dehydrocostus lactone, a natural sesquiterpene lactone, suppresses the biological characteristics of glioma, through inhibition of the NF-κB/COX-2 signaling pathway by targeting IKKβ.
Wang J, Yu Z, Wang C, Tian X, Huo X, Wang Y, Sun C, Feng L, Ma J, Zhang B, Yang Q, Ma X, Xu Y
American journal of cancer research 2017;7(6):1270-1284
American journal of cancer research 2017;7(6):1270-1284
Obatoclax and LY3009120 Efficiently Overcome Vemurafenib Resistance in Differentiated Thyroid Cancer.
Wei WJ, Sun ZK, Shen CT, Song HJ, Zhang XY, Qiu ZL, Luo QY
Theranostics 2017;7(4):987-1001
Theranostics 2017;7(4):987-1001
Exogenous H(2)S restores ischemic post-conditioning-induced cardioprotection through inhibiting endoplasmic reticulum stress in the aged cardiomyocytes.
Sun W, Yang J, Zhang Y, Xi Y, Wen X, Yuan D, Wang Y, Wei C, Wang R, Wu L, Li H, Xu C
Cell & bioscience 2017;7:67
Cell & bioscience 2017;7:67
Osterix Decreases the Chemosensitivity of Breast Cancer Cells by Upregulating GALNT14.
Wu J, Chen X, Bao Q, Duan R, Jin Y, Shui Y, Yao B, Lu X, Wang Y, Cui H, Li L, Yuan H, Ma C
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;44(3):998-1010
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;44(3):998-1010
β-Catenin Cooperates with CREB Binding Protein to Promote the Growth of Tumor Cells.
Yu W, Li L, Zheng F, Yang W, Zhao S, Tian C, Yin W, Chen Y, Guo W, Zou L, Deng W
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;44(2):467-478
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;44(2):467-478
Propofol Through Upregulating Caveolin-3 Attenuates Post-Hypoxic Mitochondrial Damage and Cell Death in H9C2 Cardiomyocytes During Hyperglycemia.
Deng F, Wang S, Zhang L, Xie X, Cai S, Li H, Xie GL, Miao HL, Yang C, Liu X, Xia Z
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;44(1):279-292
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;44(1):279-292
N-Cadherin-Mediated Activation of PI3K/Akt-GSK-3β Signaling Attenuates Nucleus Pulposus Cell Apoptosis Under High-Magnitude Compression.
Li P, Liang Z, Hou G, Song L, Zhang R, Gan Y, Zhang C, Xu Y, Zhou Q
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;44(1):229-239
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;44(1):229-239
N-Cadherin Maintains the Healthy Biology of Nucleus Pulposus Cells under High-Magnitude Compression.
Wang Z, Leng J, Zhao Y, Yu D, Xu F, Song Q, Qu Z, Zhuang X, Liu Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(6):2327-2337
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(6):2327-2337
Deoxyelephantopin Induces Reactive Oxygen Species-Mediated Apoptosis and Autophagy in Human Osteosarcoma Cells.
Zou J, Zhang Y, Sun J, Wang X, Tu H, Geng S, Liu R, Chen Y, Bi Z
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;42(5):1812-1821
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;42(5):1812-1821
Exogenous Hydrogen Sulfide Ameliorates Diabetes-Associated Cognitive Decline by Regulating the Mitochondria-Mediated Apoptotic Pathway and IL-23/IL-17 Expression in db/db Mice.
Ma S, Zhong D, Ma P, Li G, Hua W, Sun Y, Liu N, Zhang L, Zhang W
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;41(5):1838-1850
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;41(5):1838-1850
Baicalin Attenuates Cardiac Dysfunction and Myocardial Remodeling in a Chronic Pressure-Overload Mice Model.
Zhang Y, Liao P, Zhu M, Li W, Hu D, Guan S, Chen L
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;41(3):849-864
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;41(3):849-864
Capsular Polysaccharide of Mycoplasma ovipneumoniae Induces Sheep Airway Epithelial Cell Apoptosis via ROS-Dependent JNK/P38 MAPK Pathways.
Jiang Z, Song F, Li Y, Xue D, Zhao N, Zhang J, Deng G, Li M, Liu X, Wang Y
Oxidative medicine and cellular longevity 2017;2017:6175841
Oxidative medicine and cellular longevity 2017;2017:6175841
Santamarine Inhibits NF-κB Activation and Induces Mitochondrial Apoptosis in A549 Lung Adenocarcinoma Cells via Oxidative Stress.
Wu X, Zhu H, Yan J, Khan M, Yu X
BioMed research international 2017;2017:4734127
BioMed research international 2017;2017:4734127
TBHQ Alleviated Endoplasmic Reticulum Stress-Apoptosis and Oxidative Stress by PERK-Nrf2 Crosstalk in Methamphetamine-Induced Chronic Pulmonary Toxicity.
Wang Y, Gu YH, Liu M, Bai Y, Liang LY, Wang HL
Oxidative medicine and cellular longevity 2017;2017:4310475
Oxidative medicine and cellular longevity 2017;2017:4310475
Pretreatment Donors after Circulatory Death with Simvastatin Alleviates Liver Ischemia Reperfusion Injury through a KLF2-Dependent Mechanism in Rat.
Liu Z, Zhang X, Xiao Q, Ye S, Lai CH, Luo J, Huang X, Wang W, Zeng C, Zhong Z, Fan X, Xia Z, Xiong Y, Mao X, Ye Q, Wang Y
Oxidative medicine and cellular longevity 2017;2017:3861914
Oxidative medicine and cellular longevity 2017;2017:3861914
Inhibition of Caveolae Contributes to Propofol Preconditioning-Suppressed Microvesicles Release and Cell Injury by Hypoxia-Reoxygenation.
Deng F, Wang S, Cai S, Hu Z, Xu R, Wang J, Feng D, Zhang L
Oxidative medicine and cellular longevity 2017;2017:3542149
Oxidative medicine and cellular longevity 2017;2017:3542149
Relaxin Attenuates Contrast-Induced Human Proximal Tubular Epithelial Cell Apoptosis by Activation of the PI3K/Akt Signaling Pathway In Vitro.
Xie XC, Cao Y, Yang X, Xu QH, Wei W, Wang M
BioMed research international 2017;2017:2869405
BioMed research international 2017;2017:2869405
Downregulation of UBC9 promotes apoptosis of activated human LX-2 hepatic stellate cells by suppressing the canonical NF-κB signaling pathway.
Fang S, Yuan J, Shi Q, Xu T, Fu Y, Wu Z, Guo W
PloS one 2017;12(3):e0174374
PloS one 2017;12(3):e0174374
Curcumin potentiates the potent antitumor activity of ACNU against glioblastoma by suppressing the PI3K/AKT and NF-κB/COX-2 signaling pathways.
Zhao J, Zhu J, Lv X, Xing J, Liu S, Chen C, Xu Y
OncoTargets and therapy 2017;10:5471-5482
OncoTargets and therapy 2017;10:5471-5482
UNBS5162 inhibits proliferation of human retinoblastoma cells by promoting cell apoptosis.
Wang B, Shen J, Wang J
OncoTargets and therapy 2017;10:5303-5309
OncoTargets and therapy 2017;10:5303-5309
Activation of Autophagy Contributes to Sevoflurane-Induced Neurotoxicity in Fetal Rats.
Li X, Wu Z, Zhang Y, Xu Y, Han G, Zhao P
Frontiers in molecular neuroscience 2017;10:432
Frontiers in molecular neuroscience 2017;10:432
Rosiglitazone Exerts an Anti-depressive Effect in Unpredictable Chronic Mild-Stress-Induced Depressive Mice by Maintaining Essential Neuron Autophagy and Inhibiting Excessive Astrocytic Apoptosis.
Zhao Z, Zhang L, Guo XD, Cao LL, Xue TF, Zhao XJ, Yang DD, Yang J, Ji J, Huang JY, Sun XL
Frontiers in molecular neuroscience 2017;10:293
Frontiers in molecular neuroscience 2017;10:293
Adipose-Derived Stem Cell-Derived Exosomes Ameliorate Erectile Dysfunction in a Rat Model of Type 2 Diabetes.
Chen F, Zhang H, Wang Z, Ding W, Zeng Q, Liu W, Huang C, He S, Wei A
The journal of sexual medicine 2017 Sep;14(9):1084-1094
The journal of sexual medicine 2017 Sep;14(9):1084-1094
Puerarin increases the chemosensitivity of hepatocellular carcinoma cells.
Wu Z, Wu J, Fang P, Kan S
Oncology letters 2017 Sep;14(3):3006-3010
Oncology letters 2017 Sep;14(3):3006-3010
MicroRNA-145 protects follicular granulosa cells against oxidative stress-induced apoptosis by targeting Krüppel-like factor 4.
Xu L, Sun H, Zhang M, Jiang Y, Zhang C, Zhou J, Ding L, Hu Y, Yan G
Molecular and cellular endocrinology 2017 Sep 5;452:138-147
Molecular and cellular endocrinology 2017 Sep 5;452:138-147
11β-hydroxysteroid dehydrogenases-2 decreases the apoptosis of MC3T3/MLO-Y4 cells induced by glucocorticoids.
Zhang H, Zhou F, Pan Z, Bu X, Wang Y, Chen F
Biochemical and biophysical research communications 2017 Sep 2;490(4):1399-1406
Biochemical and biophysical research communications 2017 Sep 2;490(4):1399-1406
AMPK activation-dependent autophagy compromises oleanolic acid-induced cytotoxicity in human bladder cancer cells.
Song Y, Zhang P, Sun Y, Li X, Chen L, Xiao Y, Xing Y
Oncotarget 2017 Sep 15;8(40):67942-67954
Oncotarget 2017 Sep 15;8(40):67942-67954
Pretreatment with propylene glycol alginate sodium sulfate ameliorated concanavalin A-induced liver injury by regulating the PI3K/Akt pathway in mice.
Xu S, Wu L, Zhang Q, Feng J, Li S, Li J, Liu T, Mo W, Wang W, Lu X, Yu Q, Chen K, Xia Y, Lu J, Xu L, Zhou Y, Fan X, Guo C
Life sciences 2017 Sep 15;185:103-113
Life sciences 2017 Sep 15;185:103-113
In vitro anticancer activities of osthole against renal cell carcinoma cells.
Liu L, Mao J, Wang Q, Zhang Z, Wu G, Tang Q, Zhao B, Li L, Li Q
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Oct;94:1020-1027
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Oct;94:1020-1027
Melatonin potentiates the antitumor effect of curcumin by inhibiting IKKβ/NF-κB/COX-2 signaling pathway.
Shrestha S, Zhu J, Wang Q, Du X, Liu F, Jiang J, Song J, Xing J, Sun D, Hou Q, Peng Y, Zhao J, Sun X, Song X
International journal of oncology 2017 Oct;51(4):1249-1260
International journal of oncology 2017 Oct;51(4):1249-1260
Enhanced antitumor activity in A431 cells via encapsulation of 20(R)-ginsenoside Rg3 in PLGA nanoparticles.
Zhang S, Liu J, Ge B, Du M, Fu L, Fu Y, Yan Q
Drug development and industrial pharmacy 2017 Oct;43(10):1734-1741
Drug development and industrial pharmacy 2017 Oct;43(10):1734-1741
SIRT1 induces resistance to apoptosis in human granulosa cells by activating the ERK pathway and inhibiting NF-κB signaling with anti-inflammatory functions.
Han Y, Luo H, Wang H, Cai J, Zhang Y
Apoptosis : an international journal on programmed cell death 2017 Oct;22(10):1260-1272
Apoptosis : an international journal on programmed cell death 2017 Oct;22(10):1260-1272
miR-15a-5p levels correlate with poor ovarian response in human follicular fluid.
Zhang K, Zhong W, Li WP, Chen ZJ, Zhang C
Reproduction (Cambridge, England) 2017 Oct;154(4):483-496
Reproduction (Cambridge, England) 2017 Oct;154(4):483-496
Critical role of p21 on olaquindox-induced mitochondrial apoptosis and S-phase arrest involves activation of PI3K/AKT and inhibition of Nrf2/HO-1pathway.
Li D, Dai C, Yang X, Wang F, Yu X, Xiao X, Tang S
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Oct;108(Pt A):148-160
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Oct;108(Pt A):148-160
miR-181a increases FoxO1 acetylation and promotes granulosa cell apoptosis via SIRT1 downregulation.
Zhang M, Zhang Q, Hu Y, Xu L, Jiang Y, Zhang C, Ding L, Jiang R, Sun J, Sun H, Yan G
Cell death & disease 2017 Oct 5;8(10):e3088
Cell death & disease 2017 Oct 5;8(10):e3088
KIF26B, a novel oncogene, promotes proliferation and metastasis by activating the VEGF pathway in gastric cancer.
Zhang H, Ma RR, Wang XJ, Su ZX, Chen X, Shi DB, Guo XY, Liu HT, Gao P
Oncogene 2017 Oct 5;36(40):5609-5619
Oncogene 2017 Oct 5;36(40):5609-5619
An autophagic mechanism is involved in the 6-hydroxydopamine-induced neurotoxicity in vivo.
He X, Yuan W, Li Z, Feng J
Toxicology letters 2017 Oct 5;280:29-40
Toxicology letters 2017 Oct 5;280:29-40
ANP promotes proliferation and inhibits apoptosis of ovarian granulosa cells by NPRA/PGRMC1/EGFR complex and improves ovary functions of PCOS rats.
Zheng Q, Li Y, Zhang D, Cui X, Dai K, Yang Y, Liu S, Tan J, Yan Q
Cell death & disease 2017 Oct 26;8(10):e3145
Cell death & disease 2017 Oct 26;8(10):e3145
Effects of In Utero Exposure to Di-n-Butyl Phthalate on Testicular Development in Rat.
Ma T, Yin X, Han R, Ding J, Zhang H, Han X, Li D
International journal of environmental research and public health 2017 Oct 24;14(10)
International journal of environmental research and public health 2017 Oct 24;14(10)
Axin1 up-regulated 1 accelerates stress-induced cardiomyocytes apoptosis through activating Wnt/β-catenin signaling.
Ye X, Lin J, Lin Z, Xue A, Li L, Zhao Z, Liu L, Shen Y, Cong B
Experimental cell research 2017 Oct 15;359(2):441-448
Experimental cell research 2017 Oct 15;359(2):441-448
Downregulation of NMI promotes tumor growth and predicts poor prognosis in human lung adenocarcinomas.
Wang J, Zou K, Feng X, Chen M, Li C, Tang R, Xuan Y, Luo M, Chen W, Qiu H, Qin G, Li Y, Zhang C, Xiao B, Kang L, Kang T, Huang W, Yu X, Wu X, Deng W
Molecular cancer 2017 Oct 12;16(1):158
Molecular cancer 2017 Oct 12;16(1):158
Mcl-1 stabilization confers resistance to taxol in human gastric cancer.
Shuang W, Hou L, Zhu Y, Li Q, Hu W
Oncotarget 2017 Oct 10;8(47):82981-82990
Oncotarget 2017 Oct 10;8(47):82981-82990
Knockdown of SLC39A7 inhibits cell growth and induces apoptosis in human colorectal cancer cells.
Sheng N, Yan L, You W, Tan G, Gong J, Chen H, Yang Y, Hu L, Wang Z
Acta biochimica et biophysica Sinica 2017 Oct 1;49(10):926-934
Acta biochimica et biophysica Sinica 2017 Oct 1;49(10):926-934
Berberine activates caspase-9/cytochrome c-mediated apoptosis to suppress triple-negative breast cancer cells in vitro and in vivo.
Zhao Y, Jing Z, Lv J, Zhang Z, Lin J, Cao X, Zhao Z, Liu P, Mao W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Nov;95:18-24
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Nov;95:18-24
Cysteine-rich buccal gland protein suppressed the proliferation, migration and invasion of hela cells through akt pathway.
Han J, Liu Y, Jiang Q, Xiao R
IUBMB life 2017 Nov;69(11):856-866
IUBMB life 2017 Nov;69(11):856-866
Effectively enhancing cytotoxic and apoptotic effects of alpha-momorcharin by integrating a heparin-binding peptide.
Tan MJ, Cao XW, Li PF, Zhai YZ, Zhou Y, Liu YJ, Zhao J, Wang FJ
Biotechnology and applied biochemistry 2017 Nov;64(6):918-926
Biotechnology and applied biochemistry 2017 Nov;64(6):918-926
Dectin-1 is essential for IL-1β production through JNK activation and apoptosis in Aspergillus fumigatus keratitis.
Yuan K, Zhao G, Che C, Li C, Lin J, Zhu G, He K
International immunopharmacology 2017 Nov;52:168-175
International immunopharmacology 2017 Nov;52:168-175
Spatiotemporal Expression of Bcl-2/Bax and Neural Cell Apoptosis in the Developing Lumbosacral Spinal Cord of Rat Fetuses with Anorectal Malformations.
Yang Z, Geng Y, Yao Z, Jia H, Bai Y, Wang W
Neurochemical research 2017 Nov;42(11):3160-3169
Neurochemical research 2017 Nov;42(11):3160-3169
Combination of sonodynamic with temozolomide inhibits C6 glioma migration and promotes mitochondrial pathway apoptosis via suppressing NHE-1 expression.
Chen L, Cong D, Li Y, Wang D, Li Q, Hu S
Ultrasonics sonochemistry 2017 Nov;39:654-661
Ultrasonics sonochemistry 2017 Nov;39:654-661
PD149163 induces hypothermia to protect against brain injury in acute cerebral ischemic rats.
Xue TF, Ding X, Ji J, Yan H, Huang JY, Guo XD, Yang J, Sun XL
Journal of pharmacological sciences 2017 Nov;135(3):105-113
Journal of pharmacological sciences 2017 Nov;135(3):105-113
Correlation between miR-19a inhibition and radiosensitivity in SiHa cervical cancer cells.
Wang Y, Wang Y, Zhong W, Gulina K
Journal of B.U.ON. : official journal of the Balkan Union of Oncology 2017 Nov-Dec;22(6):1505-1508
Journal of B.U.ON. : official journal of the Balkan Union of Oncology 2017 Nov-Dec;22(6):1505-1508
The liver protection of propylene glycol alginate sodium sulfate preconditioning against ischemia reperfusion injury: focusing MAPK pathway activity.
Xu S, Niu P, Chen K, Xia Y, Yu Q, Liu N, Li J, Li S, Wu L, Feng J, Wang W, Lu X, Liu T, Wang F, Dai W, Fan X, Mo W, Xu L, Guo C
Scientific reports 2017 Nov 9;7(1):15175
Scientific reports 2017 Nov 9;7(1):15175
Inhibited effects of CAPE-pNO(2) on cervical carcinoma in vivo and in vitro and its detected metabolites.
Yao X, Tang H, Ren Q, Zhao X, Zuo H, Li Z
Oncotarget 2017 Nov 7;8(55):94197-94209
Oncotarget 2017 Nov 7;8(55):94197-94209
COPS5 inhibition arrests the proliferation and growth of serous ovarian cancer cells via the elevation of p27 level.
Zhang H, Zhong A, Sun J, Chen M, Xie S, Zheng H, Wang Y, Yu Y, Guo L, Lu R
Biochemical and biophysical research communications 2017 Nov 4;493(1):85-93
Biochemical and biophysical research communications 2017 Nov 4;493(1):85-93
Curcumin inhibits bladder cancer stem cells by suppressing Sonic Hedgehog pathway.
Wang D, Kong X, Li Y, Qian W, Ma J, Wang D, Yu D, Zhong C
Biochemical and biophysical research communications 2017 Nov 4;493(1):521-527
Biochemical and biophysical research communications 2017 Nov 4;493(1):521-527
Fascaplysin inhibit ovarian cancer cell proliferation and metastasis through inhibiting CDK4.
Chen S, Guan X, Wang LL, Li B, Sang XB, Liu Y, Zhao Y
Gene 2017 Nov 30;635:3-8
Gene 2017 Nov 30;635:3-8
Apelin protects against myocardial ischemic injury by inhibiting dynamin-related protein 1.
Xu W, Yu H, Ma R, Ma L, Liu Q, Shan H, Wu C, Zhang R, Zhou Y, Shan H
Oncotarget 2017 Nov 21;8(59):100034-100044
Oncotarget 2017 Nov 21;8(59):100034-100044
Quercetin exerts synergetic anti-cancer activity with 10-hydroxy camptothecin.
Tang Q, Ji F, Wang J, Guo L, Li Y, Bao Y
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2017 Nov 15;109:223-232
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2017 Nov 15;109:223-232
Dehydrobruceine B enhances the cisplatin-induced cytotoxicity through regulation of the mitochondrial apoptotic pathway in lung cancer A549 cells.
Huang Z, Yang G, Shen T, Wang X, Li H, Ren D
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 May;89:623-631
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 May;89:623-631
Antioxidation, anti-inflammation and anti-apoptosis by paeonol in LPS/d-GalN-induced acute liver failure in mice.
Gong X, Yang Y, Huang L, Zhang Q, Wan RZ, Zhang P, Zhang B
International immunopharmacology 2017 May;46:124-132
International immunopharmacology 2017 May;46:124-132
Geniposide protects pancreatic β cells from high glucose-mediated injury by activation of AMP-activated protein kinase.
Liu C, Hao Y, Yin F, Zhang Y, Liu J
Cell biology international 2017 May;41(5):544-554
Cell biology international 2017 May;41(5):544-554
The transcription factor FOXA1 induces epithelial ovarian cancer tumorigenesis and progression.
Wang LL, Xiu YL, Chen X, Sun KX, Chen S, Wu DD, Liu BL, Zhao Y
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 May;39(5):1010428317706210
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 May;39(5):1010428317706210
The soy-derived peptide Vglycin inhibits the growth of colon cancer cells in vitro and in vivo.
Gao C, Sun R, Xie YR, Jiang AL, Lin M, Li M, Chen ZW, Zhang P, Jin H, Feng JP
Experimental biology and medicine (Maywood, N.J.) 2017 May;242(10):1034-1043
Experimental biology and medicine (Maywood, N.J.) 2017 May;242(10):1034-1043
EGCG protects against homocysteine-induced human umbilical vein endothelial cells apoptosis by modulating mitochondrial-dependent apoptotic signaling and PI3K/Akt/eNOS signaling pathways.
Liu S, Sun Z, Chu P, Li H, Ahsan A, Zhou Z, Zhang Z, Sun B, Wu J, Xi Y, Han G, Lin Y, Peng J, Tang Z
Apoptosis : an international journal on programmed cell death 2017 May;22(5):672-680
Apoptosis : an international journal on programmed cell death 2017 May;22(5):672-680
PCSK9 regulates apoptosis in human lung adenocarcinoma A549 cells via endoplasmic reticulum stress and mitochondrial signaling pathways.
Xu X, Cui Y, Cao L, Zhang Y, Yin Y, Hu X
Experimental and therapeutic medicine 2017 May;13(5):1993-1999
Experimental and therapeutic medicine 2017 May;13(5):1993-1999
Diosmetin exerts anti-oxidative, anti-inflammatory and anti-apoptotic effects to protect against endotoxin-induced acute hepatic failure in mice.
Yang Y, Gong XB, Huang LG, Wang ZX, Wan RZ, Zhang P, Zhang QY, Chen Z, Zhang BS
Oncotarget 2017 May 9;8(19):30723-30733
Oncotarget 2017 May 9;8(19):30723-30733
A covalently bound inhibitor triggers EZH2 degradation through CHIP-mediated ubiquitination.
Wang X, Cao W, Zhang J, Yan M, Xu Q, Wu X, Wan L, Zhang Z, Zhang C, Qin X, Xiao M, Ye D, Liu Y, Han Z, Wang S, Mao L, Wei W, Chen W
The EMBO journal 2017 May 2;36(9):1243-1260
The EMBO journal 2017 May 2;36(9):1243-1260
Chromium contributes to human bronchial epithelial cell carcinogenesis by activating Gli2 and inhibiting autophagy.
Huang J, Wu G, Zeng R, Wang J, Cai R, Ho JC, Zhang J, Zheng Y
Toxicology research 2017 May 1;6(3):324-332
Toxicology research 2017 May 1;6(3):324-332
rLj-RGD3 induces apoptosis via the mitochondrial-dependent pathway and inhibits adhesion, migration and invasion of human HeyA8 cells via FAK pathway.
Jiang Q, Li Q, Han J, Gou M, Zheng Y, Li B, Xiao R, Wang J
International journal of biological macromolecules 2017 Mar;96:652-668
International journal of biological macromolecules 2017 Mar;96:652-668
7-O-Geranylquercetin induces apoptosis in gastric cancer cells via ROS-MAPK mediated mitochondrial signaling pathway activation.
Zhu Y, Jiang Y, Shi L, Du L, Xu X, Wang E, Sun Y, Guo X, Zou B, Wang H, Wang C, Sun L, Zhen Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Mar;87:527-538
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Mar;87:527-538
ZNF545 suppresses human hepatocellular carcinoma growth by inhibiting NF-kB signaling.
Yang W, Yang S, Zhang M, Gao D, He T, Guo M
Genes & cancer 2017 Mar;8(3-4):528-535
Genes & cancer 2017 Mar;8(3-4):528-535
Morroniside protects SK-N-SH human neuroblastoma cells against H2O2-induced damage.
Zhang JX, Wang R, Xi J, Shen L, Zhu AY, Qi Q, Wang QY, Zhang LJ, Wang FC, Lü HZ, Hu JG
International journal of molecular medicine 2017 Mar;39(3):603-612
International journal of molecular medicine 2017 Mar;39(3):603-612
The Anticonvulsant and Neuroprotective Effects of Oxysophocarpine on Pilocarpine-Induced Convulsions in Adult Male Mice.
Liu G, Wang J, Deng XH, Ma PS, Li FM, Peng XD, Niu Y, Sun T, Li YX, Yu JQ
Cellular and molecular neurobiology 2017 Mar;37(2):339-349
Cellular and molecular neurobiology 2017 Mar;37(2):339-349
miR-491-5p, mediated by Foxi1, functions as a tumor suppressor by targeting Wnt3a/β-catenin signaling in the development of gastric cancer.
Sun R, Liu Z, Tong D, Yang Y, Guo B, Wang X, Zhao L, Huang C
Cell death & disease 2017 Mar 30;8(3):e2714
Cell death & disease 2017 Mar 30;8(3):e2714
Hydrogen sulfide ameliorates chronic renal failure in rats by inhibiting apoptosis and inflammation through ROS/MAPK and NF-κB signaling pathways.
Wu D, Luo N, Wang L, Zhao Z, Bu H, Xu G, Yan Y, Che X, Jiao Z, Zhao T, Chen J, Ji A, Li Y, Lee GD
Scientific reports 2017 Mar 28;7(1):455
Scientific reports 2017 Mar 28;7(1):455
Beneficial effects of Lycium barbarum polysaccharide on spermatogenesis by improving antioxidant activity and inhibiting apoptosis in streptozotocin-induced diabetic male mice.
Shi GJ, Zheng J, Wu J, Qiao HQ, Chang Q, Niu Y, Sun T, Li YX, Yu JQ
Food & function 2017 Mar 22;8(3):1215-1226
Food & function 2017 Mar 22;8(3):1215-1226
Exogenous H(2)S regulates endoplasmic reticulum-mitochondria cross-talk to inhibit apoptotic pathways in STZ-induced type I diabetes.
Yang F, Yu X, Li T, Wu J, Zhao Y, Liu J, Sun A, Dong S, Wu J, Zhong X, Xu C, Lu F, Zhang W
American journal of physiology. Endocrinology and metabolism 2017 Mar 1;312(3):E190-E203
American journal of physiology. Endocrinology and metabolism 2017 Mar 1;312(3):E190-E203
Inhibition of Blood-Brain Barrier Disruption by an Apolipoprotein E-Mimetic Peptide Ameliorates Early Brain Injury in Experimental Subarachnoid Hemorrhage.
Pang J, Chen Y, Kuai L, Yang P, Peng J, Wu Y, Chen Y, Vitek MP, Chen L, Sun X, Jiang Y
Translational stroke research 2017 Jun;8(3):257-272
Translational stroke research 2017 Jun;8(3):257-272
miR-19 targeting of GSK3β mediates sulforaphane suppression of lung cancer stem cells.
Zhu J, Wang S, Chen Y, Li X, Jiang Y, Yang X, Li Y, Wang X, Meng Y, Zhu M, Ma X, Huang C, Wu R, Xie C, Geng S, Wu J, Zhong C, Han H
The Journal of nutritional biochemistry 2017 Jun;44:80-91
The Journal of nutritional biochemistry 2017 Jun;44:80-91
Cr(VI) induces cytotoxicity in vitro through activation of ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction via the PI3K/Akt signaling pathway.
Zhang Y, Xiao F, Liu X, Liu K, Zhou X, Zhong C
Toxicology in vitro : an international journal published in association with BIBRA 2017 Jun;41:232-244
Toxicology in vitro : an international journal published in association with BIBRA 2017 Jun;41:232-244
Simvastatin Inhibits IL-1β-Induced Apoptosis and Extracellular Matrix Degradation by Suppressing the NF-kB and MAPK Pathways in Nucleus Pulposus Cells.
Tu J, Li W, Zhang Y, Wu X, Song Y, Kang L, Liu W, Wang K, Li S, Hua W, Yang C
Inflammation 2017 Jun;40(3):725-734
Inflammation 2017 Jun;40(3):725-734
SBI0206965, a novel inhibitor of Ulk1, suppresses non-small cell lung cancer cell growth by modulating both autophagy and apoptosis pathways.
Tang F, Hu P, Yang Z, Xue C, Gong J, Sun S, Shi L, Zhang S, Li Z, Yang C, Zhang J, Xie C
Oncology reports 2017 Jun;37(6):3449-3458
Oncology reports 2017 Jun;37(6):3449-3458
Relaxin attenuates aristolochic acid induced human tubular epithelial cell apoptosis in vitro by activation of the PI3K/Akt signaling pathway.
Xie XC, Zhao N, Xu QH, Yang X, Xia WK, Chen Q, Wang M, Fei X
Apoptosis : an international journal on programmed cell death 2017 Jun;22(6):769-776
Apoptosis : an international journal on programmed cell death 2017 Jun;22(6):769-776
Nrf-2-driven long noncoding RNA ODRUL contributes to modulating silver nanoparticle-induced effects on erythroid cells.
Gao M, Zhao B, Chen M, Liu Y, Xu M, Wang Z, Liu S, Zhang C
Biomaterials 2017 Jun;130:14-27
Biomaterials 2017 Jun;130:14-27
ω-3 free fatty acids and all-trans retinoic acid synergistically induce growth inhibition of three subtypes of breast cancer cell lines.
Lin G, Zhu S, Wu Y, Song C, Wang W, Zhang Y, Chen YL, He Z
Scientific reports 2017 Jun 7;7(1):2929
Scientific reports 2017 Jun 7;7(1):2929
(-)-Epigallocatechin-3-Gallate Inhibits Colorectal Cancer Stem Cells by Suppressing Wnt/β-Catenin Pathway.
Chen Y, Wang XQ, Zhang Q, Zhu JY, Li Y, Xie CF, Li XT, Wu JS, Geng SS, Zhong CY, Han HY
Nutrients 2017 Jun 3;9(6)
Nutrients 2017 Jun 3;9(6)
The role of NLRP3 inflammasome in 5-fluorouracil resistance of oral squamous cell carcinoma.
Feng X, Luo Q, Zhang H, Wang H, Chen W, Meng G, Chen F
Journal of experimental & clinical cancer research : CR 2017 Jun 21;36(1):81
Journal of experimental & clinical cancer research : CR 2017 Jun 21;36(1):81
The osteogenesis-promoting effects of alpha-lipoic acid against glucocorticoid-induced osteoporosis through the NOX4, NF-kappaB, JNK and PI3K/AKT pathways.
Lu SY, Wang CY, Jin Y, Meng Q, Liu Q, Liu ZH, Liu KX, Sun HJ, Liu MZ
Scientific reports 2017 Jun 13;7(1):3331
Scientific reports 2017 Jun 13;7(1):3331
Polyphyllin I induces G2/M phase arrest and apoptosis in U251 human glioma cells via mitochondrial dysfunction and the JNK signaling pathway.
Liu J, Zhang Y, Chen L, Yu F, Li X, Dan Tao, Zhao J, Zhou S
Acta biochimica et biophysica Sinica 2017 Jun 1;49(6):479-486
Acta biochimica et biophysica Sinica 2017 Jun 1;49(6):479-486
Bone marrow mesenchymal stem cells repair cadmium-induced rat testis injury by inhibiting mitochondrial apoptosis.
Wang YJ, Yan J, Zou XL, Guo KJ, Zhao Y, Meng CY, Yin F, Guo L
Chemico-biological interactions 2017 Jun 1;271:39-47
Chemico-biological interactions 2017 Jun 1;271:39-47
The protective effect of propofol against TNF-α-induced apoptosis was mediated via inhibiting iNOS/NO production and maintaining intracellular Ca(2+) homeostasis in mouse hippocampal HT22 cells.
Xu Z, Lu Y, Wang J, Ding X, Chen J, Miao C
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Jul;91:664-672
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Jul;91:664-672
Cisatracurium-induced proliferation impairment and death of colorectal cancer cells, HCT116 is mediated by p53 dependent intrinsic apoptotic pathway in vitro.
Yabasin IB, Lu Z, Yu JC, Wen Q
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Jul;91:320-329
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Jul;91:320-329
DKK3 regulates cell proliferation, apoptosis and collagen synthesis in keloid fibroblasts via TGF-β1/Smad signaling pathway.
Li Y, Liu H, Liang Y, Peng P, Ma X, Zhang X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Jul;91:174-180
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Jul;91:174-180
In vitro additive antitumor effects of dimethoxycurcumin and 5-fluorouracil in colon cancer cells.
Zhao H, Liu Q, Wang S, Dai F, Cheng X, Cheng X, Chen W, Zhang M, Chen D
Cancer medicine 2017 Jul;6(7):1698-1706
Cancer medicine 2017 Jul;6(7):1698-1706
Downregulation of tyrosine threonine kinase inhibits tumor growth via G2/M arrest in human endometrioid endometrial adenocarcinoma.
Zhang J, Jiang Y, Zhao Y, Wang W, Xie Y, Wang H, Yang Y
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 Jul;39(7):1010428317712444
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 Jul;39(7):1010428317712444
Estrogen receptor-α36 is involved in icaritin induced growth inhibition of triple-negative breast cancer cells.
Wang X, Zheng N, Dong J, Wang X, Liu L, Huang J
The Journal of steroid biochemistry and molecular biology 2017 Jul;171:318-327
The Journal of steroid biochemistry and molecular biology 2017 Jul;171:318-327
Sesamol attenuates oxidative stress, apoptosis and inflammation in focal cerebral ischemia/reperfusion injury.
Gao XJ, Xie GN, Liu L, Fu ZJ, Zhang ZW, Teng LZ
Experimental and therapeutic medicine 2017 Jul;14(1):841-847
Experimental and therapeutic medicine 2017 Jul;14(1):841-847
Targeting ERK enhances the cytotoxic effect of the novel PI3K and mTOR dual inhibitor VS-5584 in preclinical models of pancreatic cancer.
Ning C, Liang M, Liu S, Wang G, Edwards H, Xia Y, Polin L, Dyson G, Taub JW, Mohammad RM, Azmi AS, Zhao L, Ge Y
Oncotarget 2017 Jul 4;8(27):44295-44311
Oncotarget 2017 Jul 4;8(27):44295-44311
Down-regulation of UBC9 increases the sensitivity of hepatocellular carcinoma to doxorubicin.
Fang S, Qiu J, Wu Z, Bai T, Guo W
Oncotarget 2017 Jul 25;8(30):49783-49795
Oncotarget 2017 Jul 25;8(30):49783-49795
Alantolactone induces apoptosis, promotes STAT3 glutathionylation and enhances chemosensitivity of A549 lung adenocarcinoma cells to doxorubicin via oxidative stress.
Maryam A, Mehmood T, Zhang H, Li Y, Khan M, Ma T
Scientific reports 2017 Jul 24;7(1):6242
Scientific reports 2017 Jul 24;7(1):6242
PKCζ phosphorylates TRAF2 to protect against intestinal ischemia-reperfusion-induced injury.
Zhou W, Yao J, Wang G, Chen Z, Li Z, Feng D, Li Y, Qasim W, Tan W, Ning S, Tian X
Cell death & disease 2017 Jul 20;8(7):e2935
Cell death & disease 2017 Jul 20;8(7):e2935
Hypertonic saline infusion suppresses apoptosis of hippocampal cells in a rat model of cardiopulmonary resuscitation.
Zhou X, Liu Y, Huang Y, Zhu S, Zhu J, Wang R
Scientific reports 2017 Jul 19;7(1):5783
Scientific reports 2017 Jul 19;7(1):5783
Mitochondria-Associated Apoptosis in Human Melanoma Cells Induced by Cardanol Monoene from Cashew Nut Shell Liquid.
Su WC, Lin YF, Yu XP, Wang YX, Lin XD, Su QZ, Shen DY, Chen QX
Journal of agricultural and food chemistry 2017 Jul 19;65(28):5620-5631
Journal of agricultural and food chemistry 2017 Jul 19;65(28):5620-5631
The synthetic antihyperlipidemic drug potassium piperate selectively kills breast cancer cells through inhibiting G1-S-phase transition and inducing apoptosis.
Fan L, Cao X, Yan H, Wang Q, Tian X, Zhang L, He X, Borjihan G, Morigen
Oncotarget 2017 Jul 18;8(29):47250-47268
Oncotarget 2017 Jul 18;8(29):47250-47268
Crude terpene glycoside component from Radix paeoniae rubra protects against isoproterenol-induced myocardial ischemic injury via activation of the PI3K/AKT/mTOR signaling pathway.
Ke Z, Wang G, Yang L, Qiu H, Wu H, Du M, Chen J, Song J, Jia X, Feng L
Journal of ethnopharmacology 2017 Jul 12;206:160-169
Journal of ethnopharmacology 2017 Jul 12;206:160-169
Inducible Bcl-2 gene RNA interference mediated by aptamer-integrated HDV ribozyme switch.
Zhang Y, Wang J, Cheng H, Sun N, Liu M, Wu Z, Pei R
Integrative biology : quantitative biosciences from nano to macro 2017 Jul 1;9(7):619-626
Integrative biology : quantitative biosciences from nano to macro 2017 Jul 1;9(7):619-626
7-O-geranylquercetin-induced autophagy contributes to apoptosis via ROS generation in human non-small cell lung cancer cells.
Wang EX, Zou BY, Shi L, Du LY, Zhu YY, Jiang YM, Ma XD, Kang XH, Wang CY, Zhen YH, Sun LD
Life sciences 2017 Jul 1;180:102-113
Life sciences 2017 Jul 1;180:102-113
Low-level laser therapy for beta amyloid toxicity in rat hippocampus.
Lu Y, Wang R, Dong Y, Tucker D, Zhao N, Ahmed ME, Zhu L, Liu TC, Cohen RM, Zhang Q
Neurobiology of aging 2017 Jan;49:165-182
Neurobiology of aging 2017 Jan;49:165-182
Anti-inflammatory and neuroprotective effects of sanguinarine following cerebral ischemia in rats.
Wang Q, Dai P, Bao H, Liang P, Wang W, Xing A, Sun J
Experimental and therapeutic medicine 2017 Jan;13(1):263-268
Experimental and therapeutic medicine 2017 Jan;13(1):263-268
Targeting P-glycoprotein function, p53 and energy metabolism: Combination of metformin and 2-deoxyglucose reverses the multidrug resistance of MCF-7/Dox cells to doxorubicin.
Xue C, Wang C, Sun Y, Meng Q, Liu Z, Huo X, Sun P, Sun H, Ma X, Ma X, Peng J, Liu K
Oncotarget 2017 Jan 31;8(5):8622-8632
Oncotarget 2017 Jan 31;8(5):8622-8632
Discovery of a novel Nrf2 inhibitor that induces apoptosis of human acute myeloid leukemia cells.
Zhang J, Su L, Ye Q, Zhang S, Kung H, Jiang F, Jiang G, Miao J, Zhao B
Oncotarget 2017 Jan 31;8(5):7625-7636
Oncotarget 2017 Jan 31;8(5):7625-7636
Deoxyelephantopin induces apoptosis in HepG2 cells via oxidative stress, NF-κB inhibition and mitochondrial dysfunction.
Mehmood T, Maryam A, Zhang H, Li Y, Khan M, Ma T
BioFactors (Oxford, England) 2017 Jan 2;43(1):63-72
BioFactors (Oxford, England) 2017 Jan 2;43(1):63-72
Effect of Oleracein E, a Neuroprotective Tetrahydroisoquinoline, on Rotenone-Induced Parkinson's Disease Cell and Animal Models.
Sun H, He X, Liu C, Li L, Zhou R, Jin T, Yue S, Feng D, Gong J, Sun J, Ji J, Xiang L
ACS chemical neuroscience 2017 Jan 18;8(1):155-164
ACS chemical neuroscience 2017 Jan 18;8(1):155-164
Wnt/β-catenin pathway mediates (-)-Epigallocatechin-3-gallate (EGCG) inhibition of lung cancer stem cells.
Zhu J, Jiang Y, Yang X, Wang S, Xie C, Li X, Li Y, Chen Y, Wang X, Meng Y, Zhu M, Wu R, Huang C, Ma X, Geng S, Wu J, Zhong C
Biochemical and biophysical research communications 2017 Jan 1;482(1):15-21
Biochemical and biophysical research communications 2017 Jan 1;482(1):15-21
Propofol enhances the cisplatin-induced apoptosis on cervical cancer cells via EGFR/JAK2/STAT3 pathway.
Li H, Lu Y, Pang Y, Li M, Cheng X, Chen J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Feb;86:324-333
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Feb;86:324-333
Inhibition of store-operated Ca(2+) entry counteracts the apoptosis of nasopharyngeal carcinoma cells induced by sodium butyrate.
Huang W, Ren C, Huang G, Liu J, Liu W, Wang L, Zhu B, Feng X, Shi J, Li J, Xia X, Jia W, Chen J, Chen Y, Jiang X
Oncology letters 2017 Feb;13(2):921-929
Oncology letters 2017 Feb;13(2):921-929
Triggering of apoptosis in osteosarcoma cells by graphene/single-walled carbon nanotube hybrids via the ROS-mediated mitochondrial pathway.
Yan X, Yang W, Shao Z, Yang S, Liu X
Journal of biomedical materials research. Part A 2017 Feb;105(2):443-453
Journal of biomedical materials research. Part A 2017 Feb;105(2):443-453
The protective effects of propofol against CoCl(2)-induced HT22 cell hypoxia injury via PP2A/CAMKIIα/nNOS pathway.
Lu Y, Chen W, Lin C, Wang J, Zhu M, Chen J, Miao C
BMC anesthesiology 2017 Feb 28;17(1):32
BMC anesthesiology 2017 Feb 28;17(1):32
Propylene Glycol Alginate Sodium Sulfate Alleviates Cerulein-Induced Acute Pancreatitis by Modulating the MEK/ERK Pathway in Mice.
Zhang H, Li Y, Li L, Liu H, Hu L, Dai Y, Chen J, Xu S, Chen W, Xu X, Xu X
Marine drugs 2017 Feb 17;15(2)
Marine drugs 2017 Feb 17;15(2)
Induction of autophagy by an oleanolic acid derivative, SZC017, promotes ROS-dependent apoptosis through Akt and JAK2/STAT3 signaling pathway in human lung cancer cells.
Song Y, Kong L, Sun B, Gao L, Chu P, Ahsan A, Qaed E, Lin Y, Peng J, Ma X, Zhang J, Wang S, Tang Z
Cell biology international 2017 Dec;41(12):1367-1378
Cell biology international 2017 Dec;41(12):1367-1378
Doxepin Mitigates Noise-induced Neuronal Damage in Primary Auditory Cortex of Mice via Suppression of Acid Sphingomyelinase/Ceramide Pathway.
Su YT, Meng XX, Zhang X, Guo YB, Zhang HJ, Cheng YP, Xie XP, Chang YM, Bao JX
Anatomical record (Hoboken, N.J. : 2007) 2017 Dec;300(12):2220-2232
Anatomical record (Hoboken, N.J. : 2007) 2017 Dec;300(12):2220-2232
2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin promotes endothelial cell apoptosis through activation of EP3/p38MAPK/Bcl-2 pathway.
Yu Y, Liu Q, Guo S, Zhang Q, Tang J, Liu G, Kong D, Li J, Yan S, Wang R, Wang P, Su X, Yu Y
Journal of cellular and molecular medicine 2017 Dec;21(12):3540-3551
Journal of cellular and molecular medicine 2017 Dec;21(12):3540-3551
Hydrogen Sulphide modulating mitochondrial morphology to promote mitophagy in endothelial cells under high-glucose and high-palmitate.
Liu N, Wu J, Zhang L, Gao Z, Sun Y, Yu M, Zhao Y, Dong S, Lu F, Zhang W
Journal of cellular and molecular medicine 2017 Dec;21(12):3190-3203
Journal of cellular and molecular medicine 2017 Dec;21(12):3190-3203
The inflammatory responses in Cu-mediated elemental imbalance is associated with mitochondrial fission and intrinsic apoptosis in Gallus gallus heart.
Li S, Zhao H, Wang Y, Shao Y, Li J, Liu J, Xing M
Chemosphere 2017 Dec;189:489-497
Chemosphere 2017 Dec;189:489-497
Hyperthermia with different temperatures inhibits proliferation and promotes apoptosis through the EGFR/STAT3 pathway in C6 rat glioma cells.
Chen YD, Zhang Y, Dong TX, Xu YT, Zhang W, An TT, Liu PF, Yang XH
Molecular medicine reports 2017 Dec;16(6):9401-9408
Molecular medicine reports 2017 Dec;16(6):9401-9408
Gaseous signalling molecule SO2 via Hippo‑MST pathway to improve myocardial fibrosis of diabetic rats.
Liu M, Liu S, Tan W, Tang F, Long J, Li Z, Liang B, Chu C, Yang J
Molecular medicine reports 2017 Dec;16(6):8953-8963
Molecular medicine reports 2017 Dec;16(6):8953-8963
Antitumor effects of baicalin on ovarian cancer cells through induction of cell apoptosis and inhibition of cell migration in vitro.
Gao C, Zhou Y, Li H, Cong X, Jiang Z, Wang X, Cao R, Tian W
Molecular medicine reports 2017 Dec;16(6):8729-8734
Molecular medicine reports 2017 Dec;16(6):8729-8734
Abnormal expression levels of BMP15/Smad1 are associated with granulosa cell apoptosis in patients with polycystic ovary syndrome.
Cui X, Jing X, Wu X, Bi X, Liu J, Long Z, Zhang X, Zhang D, Jia H, Su D, Huo K
Molecular medicine reports 2017 Dec;16(6):8231-8236
Molecular medicine reports 2017 Dec;16(6):8231-8236
Overexpression of microRNA-1470 promotes proliferation and migration, and inhibits senescence of esophageal squamous carcinoma cells.
Mei LL, Qiu YT, Wang WJ, Bai J, Shi ZZ
Oncology letters 2017 Dec;14(6):7753-7758
Oncology letters 2017 Dec;14(6):7753-7758
Effect of fraxetin on proliferation and apoptosis in breast cancer cells.
Liu G, Liu Z, Yan Y, Wang H
Oncology letters 2017 Dec;14(6):7374-7378
Oncology letters 2017 Dec;14(6):7374-7378
Phloretin induces apoptosis of human esophageal cancer via a mitochondria-dependent pathway.
Duan H, Wang R, Yan X, Liu H, Zhang Y, Mu D, Han J, Li X
Oncology letters 2017 Dec;14(6):6763-6768
Oncology letters 2017 Dec;14(6):6763-6768
Ouabain targets the Na(+)/K(+)-ATPase α(3) isoform to inhibit cancer cell proliferation and induce apoptosis.
Xiao Y, Meng C, Lin J, Huang C, Zhang X, Long Y, Huang Y, Lin Y
Oncology letters 2017 Dec;14(6):6678-6684
Oncology letters 2017 Dec;14(6):6678-6684
Inhibition of chemotherapy-induced apoptosis of testicular cells by squid ink polysaccharide.
Gu YP, Yang XM, Duan ZH, Luo P, Shang JH, Xiao W, Tao YX, Zhang DY, Zhang YB, Liu HZ
Experimental and therapeutic medicine 2017 Dec;14(6):5889-5895
Experimental and therapeutic medicine 2017 Dec;14(6):5889-5895
The regulation of NLRP3 inflammasome expression during the development of cardiac contractile dysfunction in chronic kidney disease.
Chin LH, Hsu YJ, Hsu SC, Chen YH, Chang YL, Huang SM, Tsai CS, Lin CY
Oncotarget 2017 Dec 26;8(69):113303-113317
Oncotarget 2017 Dec 26;8(69):113303-113317
Adenovirus-mediated artificial miRNA targetting fibrinogen-like protein 2 attenuates the severity of acute pancreatitis in mice.
Ye X, Ding J, Chen Y, Dong J
Bioscience reports 2017 Dec 22;37(6)
Bioscience reports 2017 Dec 22;37(6)
Mesenchymal stem cell conditioned medium alleviates oxidative stress injury induced by hydrogen peroxide via regulating miR143 and its target protein in hepatocytes.
Xu X, Li D, Li X, Shi Q, Ju X
BMC immunology 2017 Dec 19;18(1):51
BMC immunology 2017 Dec 19;18(1):51
Vitamin D enhances omega-3 polyunsaturated fatty acids-induced apoptosis in breast cancer cells.
Yang J, Zhu S, Lin G, Song C, He Z
Cell biology international 2017 Aug;41(8):890-897
Cell biology international 2017 Aug;41(8):890-897
Anti-colon cancer effect of caffeic acid p-nitro-phenethyl ester in vitro and in vivo and detection of its metabolites.
Tang H, Yao X, Yao C, Zhao X, Zuo H, Li Z
Scientific reports 2017 Aug 8;7(1):7599
Scientific reports 2017 Aug 8;7(1):7599
mTORC1 regulates apoptosis and cell proliferation in pterygium via targeting autophagy and FGFR3.
Liu Y, Xu H, An M
Scientific reports 2017 Aug 4;7(1):7339
Scientific reports 2017 Aug 4;7(1):7339
Kaiso protects human umbilical vein endothelial cells against apoptosis by differentially regulating the expression of B-cell CLL/lymphoma 2 family members.
Xue X, Zhang J, Lan H, Xu Y, Wang H
Scientific reports 2017 Aug 2;7(1):7116
Scientific reports 2017 Aug 2;7(1):7116
Resveratrol inhibits age-dependent spontaneous tumorigenesis by SIRT1-mediated post-translational modulations in the annual fish Nothobranchius guentheri.
Liu T, Ma L, Zheng Z, Li F, Liu S, Xie Y, Li G
Oncotarget 2017 Aug 15;8(33):55422-55434
Oncotarget 2017 Aug 15;8(33):55422-55434
Establishment of an ideal time window model in hypothermic-targeted temperature management after traumatic brain injury in rats.
Zhao WY, Chen SB, Wang JJ, Xu C, Zhao ML, Dong HJ, Liang HQ, Li XH, Tu Y, Zhang S, Chen C, Sun HT
Brain research 2017 Aug 15;1669:141-149
Brain research 2017 Aug 15;1669:141-149
Exogenous H(2)S facilitating ubiquitin aggregates clearance via autophagy attenuates type 2 diabetes-induced cardiomyopathy.
Wu J, Tian Z, Sun Y, Lu C, Liu N, Gao Z, Zhang L, Dong S, Yang F, Zhong X, Xu C, Lu F, Zhang W
Cell death & disease 2017 Aug 10;8(8):e2992
Cell death & disease 2017 Aug 10;8(8):e2992
Epigallocatechin-3-gallate inhibits H(2)O(2)-induced apoptosis in Mouse Vascular Smooth Muscle Cells via 67kD Laminin Receptor.
Yan X, Li Y, Yu H, Wang W, Wu C, Yang Y, Hu Y, Shi X, Li J
Scientific reports 2017 Aug 10;7(1):7774
Scientific reports 2017 Aug 10;7(1):7774
Phosphocreatine protects endothelial cells from Methylglyoxal induced oxidative stress and apoptosis via the regulation of PI3K/Akt/eNOS and NF-κB pathway.
Chu P, Han G, Ahsan A, Sun Z, Liu S, Zhang Z, Sun B, Song Y, Lin Y, Peng J, Tang Z
Vascular pharmacology 2017 Apr;91:26-35
Vascular pharmacology 2017 Apr;91:26-35
Protective effect of calretinin on testicular Leydig cells via the inhibition of apoptosis.
Xu W, Zhu Q, Zhang B, Liu S, Dai X, Gao C, Gao L, Cui Y
Aging 2017 Apr;9(4):1269-1279
Aging 2017 Apr;9(4):1269-1279
Protective effect of naringin against the LPS-induced apoptosis of PC12 cells: Implications for the treatment of neurodegenerative disorders.
Wang H, Xu YS, Wang ML, Cheng C, Bian R, Yuan H, Wang Y, Guo T, Zhu LL, Zhou H
International journal of molecular medicine 2017 Apr;39(4):819-830
International journal of molecular medicine 2017 Apr;39(4):819-830
Curcumin Suppresses Lung Cancer Stem Cells via Inhibiting Wnt/β-catenin and Sonic Hedgehog Pathways.
Zhu JY, Yang X, Chen Y, Jiang Y, Wang SJ, Li Y, Wang XQ, Meng Y, Zhu MM, Ma X, Huang C, Wu R, Xie CF, Li XT, Geng SS, Wu JS, Zhong CY, Han HY
Phytotherapy research : PTR 2017 Apr;31(4):680-688
Phytotherapy research : PTR 2017 Apr;31(4):680-688
Sox2 inhibits Wnt-β-catenin signaling and metastatic potency of cisplatin-resistant lung adenocarcinoma cells.
He J, Shi J, Zhang K, Xue J, Li J, Yang J, Chen J, Wei J, Ren H, Liu X
Molecular medicine reports 2017 Apr;15(4):1693-1701
Molecular medicine reports 2017 Apr;15(4):1693-1701
Atorvastatin prevents Angiotensin II induced myocardial hypertrophy in vitro via CCAAT/enhancer-binding protein β.
Chen Y, Yu S, Zhang N, Li Y, Chen S, Chang Y, Sun G, Sun Y
Biochemical and biophysical research communications 2017 Apr 29;486(2):423-430
Biochemical and biophysical research communications 2017 Apr 29;486(2):423-430
Down-regulation of miR-146b-5p by long noncoding RNA MALAT1 in hepatocellular carcinoma promotes cancer growth and metastasis.
Li C, Miao R, Liu S, Wan Y, Zhang S, Deng Y, Bi J, Qu K, Zhang J, Liu C
Oncotarget 2017 Apr 25;8(17):28683-28695
Oncotarget 2017 Apr 25;8(17):28683-28695
The mir-675-5p regulates the progression and development of pancreatic cancer via the UBQLN1-ZEB1-mir200 axis.
Wang J, Zhang Y, Wei H, Zhang X, Wu Y, Gong A, Xia Y, Wang W, Xu M
Oncotarget 2017 Apr 11;8(15):24978-24987
Oncotarget 2017 Apr 11;8(15):24978-24987
High glucose induces apoptosis via upregulation of Bim expression in proximal tubule epithelial cells.
Zhang XQ, Dong JJ, Cai T, Shen X, Zhou XJ, Liao L
Oncotarget 2017 Apr 11;8(15):24119-24129
Oncotarget 2017 Apr 11;8(15):24119-24129
Thiol peroxiredoxin, a novel allergen from Bombyx mori, modulates functions of macrophages and dendritic cells.
Wang H, Hu W, Liang Z, Zeng L, Li J, Yan H, Yang P, Liu Z, Wang L
American journal of translational research 2016;8(12):5320-5329
American journal of translational research 2016;8(12):5320-5329
Hypoxia Promotes Gastric Cancer Malignancy Partly through the HIF-1α Dependent Transcriptional Activation of the Long Non-coding RNA GAPLINC.
Liu L, Zhao X, Zou H, Bai R, Yang K, Tian Z
Frontiers in physiology 2016;7:420
Frontiers in physiology 2016;7:420
Hydrogen sulfide decreases high glucose/palmitate-induced autophagy in endothelial cells by the Nrf2-ROS-AMPK signaling pathway.
Liu J, Wu J, Sun A, Sun Y, Yu X, Liu N, Dong S, Yang F, Zhang L, Zhong X, Xu C, Lu F, Zhang W
Cell & bioscience 2016;6:33
Cell & bioscience 2016;6:33
Exogenous H2S contributes to recovery of ischemic post-conditioning-induced cardioprotection by decrease of ROS level via down-regulation of NF-κB and JAK2-STAT3 pathways in the aging cardiomyocytes.
Li L, Li M, Li Y, Sun W, Wang Y, Bai S, Li H, Wu B, Yang G, Wang R, Wu L, Li H, Xu C
Cell & bioscience 2016;6:26
Cell & bioscience 2016;6:26
Sulforaphane induces apoptosis and inhibits invasion in U251MG glioblastoma cells.
Zhang Z, Li C, Shang L, Zhang Y, Zou R, Zhan Y, Bi B
SpringerPlus 2016;5:235
SpringerPlus 2016;5:235
ML-7 amplifies the quinocetone-induced cell death through akt and MAPK-mediated apoptosis on HepG2 cell line.
Zhou Y, Zhang S, Deng S, Dai C, Tang S, Yang X, Li D, Zhao K, Xiao X
Toxicology mechanisms and methods 2016;26(1):11-21
Toxicology mechanisms and methods 2016;26(1):11-21
Ghrelin Protects against Dexamethasone-Induced INS-1 Cell Apoptosis via ERK and p38MAPK Signaling.
Zhang C, Li L, Zhao B, Jiao A, Li X, Sun N, Zhang J
International journal of endocrinology 2016;2016:4513051
International journal of endocrinology 2016;2016:4513051
Wnt5a Increases Properties of Lung Cancer Stem Cells and Resistance to Cisplatin through Activation of Wnt5a/PKC Signaling Pathway.
Yang J, Zhang K, Wu J, Shi J, Xue J, Li J, Chen J, Zhu Y, Wei J, He J, Liu X
Stem cells international 2016;2016:1690896
Stem cells international 2016;2016:1690896
Vitamin K2 Induces Mitochondria-Related Apoptosis in Human Bladder Cancer Cells via ROS and JNK/p38 MAPK Signal Pathways.
Duan F, Yu Y, Guan R, Xu Z, Liang H, Hong L
PloS one 2016;11(8):e0161886
PloS one 2016;11(8):e0161886
Development of Novel Erythromycin Derivatives with Inhibitory Activity against Proliferation of Tumor Cells.
Wu L, Bao K, Song R, Wang D, Zhang L, Wang W, Zhang W, Bin W
PloS one 2016;11(7):e0159503
PloS one 2016;11(7):e0159503
OFD1, as a Ciliary Protein, Exhibits Neuroprotective Function in Photoreceptor Degeneration Models.
Wang J, Chen X, Wang F, Zhang J, Li P, Li Z, Xu J, Gao F, Jin C, Tian H, Zhang J, Li W, Lu L, Xu GT
PloS one 2016;11(5):e0155860
PloS one 2016;11(5):e0155860
Colistin-Induced Apoptosis of Neuroblastoma-2a Cells Involves the Generation of Reactive Oxygen Species, Mitochondrial Dysfunction, and Autophagy.
Dai C, Tang S, Velkov T, Xiao X
Molecular neurobiology 2016 Sep;53(7):4685-700
Molecular neurobiology 2016 Sep;53(7):4685-700
Effect of GADD45a on olaquindox-induced apoptosis in human hepatoma G2 cells: Involvement of mitochondrial dysfunction.
Li D, Dai C, Zhou Y, Yang X, Zhao K, Xiao X, Tang S
Environmental toxicology and pharmacology 2016 Sep;46:140-146
Environmental toxicology and pharmacology 2016 Sep;46:140-146
Progranulin protects against endotoxin-induced acute kidney injury by downregulating renal cell death and inflammatory responses in mice.
Xu X, Gou L, Zhou M, Yang F, Zhao Y, Feng T, Shi P, Ghavamian A, Zhao W, Yu Y, Lu Y, Yi F, Liu G, Tang W
International immunopharmacology 2016 Sep;38:409-19
International immunopharmacology 2016 Sep;38:409-19
Propranolol sensitizes thyroid cancer cells to cytotoxic effect of vemurafenib.
Wei WJ, Shen CT, Song HJ, Qiu ZL, Luo QY
Oncology reports 2016 Sep;36(3):1576-84
Oncology reports 2016 Sep;36(3):1576-84
Co-expression of ING4 and P53 enhances hypopharyngeal cancer chemosensitivity to cisplatin in vivo.
Ren X, Liu H, Zhang M, Wang M, Ma S
Molecular medicine reports 2016 Sep;14(3):2431-8
Molecular medicine reports 2016 Sep;14(3):2431-8
Berberine enhances the anti‑tumor activity of tamoxifen in drug‑sensitive MCF‑7 and drug‑resistant MCF‑7/TAM cells.
Wen C, Wu L, Fu L, Zhang X, Zhou H
Molecular medicine reports 2016 Sep;14(3):2250-6
Molecular medicine reports 2016 Sep;14(3):2250-6
Mir143-BBC3 cascade reduces microglial survival via interplay between apoptosis and autophagy: Implications for methamphetamine-mediated neurotoxicity.
Zhang Y, Shen K, Bai Y, Lv X, Huang R, Zhang W, Chao J, Nguyen LK, Hua J, Gan G, Hu G, Yao H
Autophagy 2016 Sep;12(9):1538-59
Autophagy 2016 Sep;12(9):1538-59
Polyphenols from hawthorn peels and fleshes differently mitigate dyslipidemia, inflammation and oxidative stress in association with modulation of liver injury in high fructose diet-fed mice.
Han X, Li W, Huang D, Yang X
Chemico-biological interactions 2016 Sep 25;257:132-40
Chemico-biological interactions 2016 Sep 25;257:132-40
Mycoplasma ovipneumoniae induces sheep airway epithelial cell apoptosis through an ERK signalling-mediated mitochondria pathway.
Li Y, Jiang Z, Xue D, Deng G, Li M, Liu X, Wang Y
BMC microbiology 2016 Sep 23;16(1):222
BMC microbiology 2016 Sep 23;16(1):222
Non-benzoquinone geldanamycin analogs trigger various forms of death in human breast cancer cells.
Zhang Z, Li HM, Zhou C, Li Q, Ma L, Zhang Z, Sun Y, Wang L, Zhang X, Zhu B, Hong YS, Wu CZ, Liu H
Journal of experimental & clinical cancer research : CR 2016 Sep 22;35(1):149
Journal of experimental & clinical cancer research : CR 2016 Sep 22;35(1):149
BG-4, a novel anticancer peptide from bitter gourd (Momordica charantia), promotes apoptosis in human colon cancer cells.
Dia VP, Krishnan HB
Scientific reports 2016 Sep 15;6:33532
Scientific reports 2016 Sep 15;6:33532
3,3'-diindolylmethane mitigates total body irradiation-induced hematopoietic injury in mice.
Lu L, Dong J, Li D, Zhang J, Fan S
Free radical biology & medicine 2016 Oct;99:463-471
Free radical biology & medicine 2016 Oct;99:463-471
Knockdown of USP39 induces cell cycle arrest and apoptosis in melanoma.
Zhao Y, Zhang B, Lei Y, Sun J, Zhang Y, Yang S, Zhang X
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Oct;37(10):13167-13176
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Oct;37(10):13167-13176
Effect of Polygonatum odoratum extract on human breast cancer MDA-MB-231 cell proliferation and apoptosis.
Tai Y, Sun YM, Zou X, Pan Q, Lan YD, Huo Q, Zhu JW, Guo F, Zheng CQ, Wu CZ, Liu H
Experimental and therapeutic medicine 2016 Oct;12(4):2681-2687
Experimental and therapeutic medicine 2016 Oct;12(4):2681-2687
Novel recombinant protein FlaA N/C increases tumor radiosensitivity via NF-κB signaling in murine breast cancer cells.
Xu Y, Wu D, Fan Y, Li P, Du H, Shi J, Wang D, Zhou X
Oncology letters 2016 Oct;12(4):2632-2640
Oncology letters 2016 Oct;12(4):2632-2640
Deep hypothermia-enhanced autophagy protects PC12 cells against oxygen glucose deprivation via a mitochondrial pathway.
Tang D, Wang C, Gao Y, Pu J, Long J, Xu W
Neuroscience letters 2016 Oct 6;632:79-85
Neuroscience letters 2016 Oct 6;632:79-85
Neuroprotective effects of Kaempferide-7-O-(4″-O-acetylrhamnosyl)-3-O-rutinoside on cerebral ischemia-reperfusion injury in rats.
Wang S, Xu H, Xin Y, Li M, Fu W, Wang Y, Lu Z, Yu X, Sui D
European journal of pharmacology 2016 Oct 5;788:335-342
European journal of pharmacology 2016 Oct 5;788:335-342
Doxorubicin and resveratrol co-delivery nanoparticle to overcome doxorubicin resistance.
Zhao Y, Huan ML, Liu M, Cheng Y, Sun Y, Cui H, Liu DZ, Mei QB, Zhou SY
Scientific reports 2016 Oct 12;6:35267
Scientific reports 2016 Oct 12;6:35267
Capsaicin mediates caspases activation and induces apoptosis through P38 and JNK MAPK pathways in human renal carcinoma.
Liu T, Wang G, Tao H, Yang Z, Wang Y, Meng Z, Cao R, Xiao Y, Wang X, Zhou J
BMC cancer 2016 Oct 12;16(1):790
BMC cancer 2016 Oct 12;16(1):790
Anticancer effect of SZC015 on lung cancer cells through ROS-dependent apoptosis and autophagy induction mechanisms in vitro.
Sun B, Gao L, Ahsan A, Chu P, Song Y, Li H, Zhang Z, Lin Y, Peng J, Song Z, Wang S, Tang Z
International immunopharmacology 2016 Nov;40:400-409
International immunopharmacology 2016 Nov;40:400-409
Depletion of JMJD5 sensitizes tumor cells to microtubule-destabilizing agents by altering microtubule stability.
Wu J, He Z, Wang DL, Sun FL
Cell cycle (Georgetown, Tex.) 2016 Nov;15(21):2980-2991
Cell cycle (Georgetown, Tex.) 2016 Nov;15(21):2980-2991
Age-associated up-regulation of EGR1 promotes granulosa cell apoptosis during follicle atresia in mice through the NF-κB pathway.
Yuan S, Wen J, Cheng J, Shen W, Zhou S, Yan W, Shen L, Luo A, Wang S
Cell cycle (Georgetown, Tex.) 2016 Nov;15(21):2895-2905
Cell cycle (Georgetown, Tex.) 2016 Nov;15(21):2895-2905
Design, synthesis, and biological evaluation of (2E)-(2-oxo-1, 2-dihydro-3H-indol-3-ylidene)acetate derivatives as anti-proliferative agents through ROS-induced cell apoptosis.
Song Z, Chen CP, Liu J, Wen X, Sun H, Yuan H
European journal of medicinal chemistry 2016 Nov 29;124:809-819
European journal of medicinal chemistry 2016 Nov 29;124:809-819
Alpha-lipoic acid defends homocysteine-induced endoplasmic reticulum and oxidative stress in HAECs.
Hu H, Wang C, Jin Y, Meng Q, Liu Q, Liu K, Sun H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 May;80:63-72
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 May;80:63-72
Triazole fungicide tebuconazole disrupts human placental trophoblast cell functions.
Zhou J, Zhang J, Li F, Liu J
Journal of hazardous materials 2016 May 5;308:294-302
Journal of hazardous materials 2016 May 5;308:294-302
The p38 MAPK inhibitor BIRB796 enhances the antitumor effects of VX680 in cervical cancer.
Jin X, Mo Q, Zhang Y, Gao Y, Wu Y, Li J, Hao X, Ma D, Gao Q, Chen P
Cancer biology & therapy 2016 May 3;17(5):566-76
Cancer biology & therapy 2016 May 3;17(5):566-76
Ginsenoside Rg3 induces FUT4-mediated apoptosis in H. pylori CagA-treated gastric cancer cells by regulating SP1 and HSF1 expressions.
Aziz F, Wang X, Liu J, Yan Q
Toxicology in vitro : an international journal published in association with BIBRA 2016 Mar;31:158-66
Toxicology in vitro : an international journal published in association with BIBRA 2016 Mar;31:158-66
β-Carotene Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cell Lines via the Cav-1/AKT/NF-κB Signaling Pathway.
Zhu X, Zhang Y, Li Q, Yang L, Zhang N, Ma S, Zhang K, Song J, Guan F
Journal of biochemical and molecular toxicology 2016 Mar;30(3):148-57
Journal of biochemical and molecular toxicology 2016 Mar;30(3):148-57
Phosphocreatine protects against LPS-induced human umbilical vein endothelial cell apoptosis by regulating mitochondrial oxidative phosphorylation.
Sun Z, Lan X, Ahsan A, Xi Y, Liu S, Zhang Z, Chu P, Song Y, Piao F, Peng J, Lin Y, Han G, Tang Z
Apoptosis : an international journal on programmed cell death 2016 Mar;21(3):283-97
Apoptosis : an international journal on programmed cell death 2016 Mar;21(3):283-97
Progranulin deficiency leads to severe inflammation, lung injury and cell death in a mouse model of endotoxic shock.
Yu Y, Xu X, Liu L, Mao S, Feng T, Lu Y, Cheng Y, Wang H, Zhao W, Tang W
Journal of cellular and molecular medicine 2016 Mar;20(3):506-17
Journal of cellular and molecular medicine 2016 Mar;20(3):506-17
Pseudolaric acid B activates autophagy in MCF-7 human breast cancer cells to prevent cell death.
Yu J, Chen C, Xu T, Yan M, Xue B, Wang Y, Liu C, Zhong T, Wang Z, Meng X, Hu D, Yu X
Oncology letters 2016 Mar;11(3):1731-1737
Oncology letters 2016 Mar;11(3):1731-1737
Dioscin suppresses human laryngeal cancer cells growth via induction of cell-cycle arrest and MAPK-mediated mitochondrial-derived apoptosis and inhibition of tumor invasion.
Si L, Zheng L, Xu L, Yin L, Han X, Qi Y, Xu Y, Wang C, Peng J
European journal of pharmacology 2016 Mar 5;774:105-17
European journal of pharmacology 2016 Mar 5;774:105-17
miR-194 inhibits the proliferation, invasion, migration, and enhances the chemosensitivity of non-small cell lung cancer cells by targeting forkhead box A1 protein.
Zhu X, Li D, Yu F, Jia C, Xie J, Ma Y, Fan S, Cai H, Luo Q, Lv Z, Fan L
Oncotarget 2016 Mar 15;7(11):13139-52
Oncotarget 2016 Mar 15;7(11):13139-52
MiR-125a-5p decreases after long non-coding RNA HOTAIR knockdown to promote cancer cell apoptosis by releasing caspase 2.
Tang L, Shen H, Li X, Li Z, Liu Z, Xu J, Ma S, Zhao X, Bai X, Li M, Wang Q, Ji J
Cell death & disease 2016 Mar 10;7(3):e2137
Cell death & disease 2016 Mar 10;7(3):e2137
Oleanolic acid inhibits cell survival and proliferation of prostate cancer cells in vitro and in vivo through the PI3K/Akt pathway.
Li X, Song Y, Zhang P, Zhu H, Chen L, Xiao Y, Xing Y
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Jun;37(6):7599-613
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Jun;37(6):7599-613
Suppression of SOX18 by siRNA inhibits cell growth and invasion of breast cancer cells.
Zhang J, Ma Y, Wang S, Chen F, Gu Y
Oncology reports 2016 Jun;35(6):3721-7
Oncology reports 2016 Jun;35(6):3721-7
Matrigel and Activin A promote cell-cell contact and anti-apoptotic activity in cultured human retinal pigment epithelium cells.
Guo X, Zhu D, Lian R, Han Y, Guo Y, Li Z, Tang S, Chen J
Experimental eye research 2016 Jun;147:37-49
Experimental eye research 2016 Jun;147:37-49
Synergistic chemopreventive effects of curcumin and berberine on human breast cancer cells through induction of apoptosis and autophagic cell death.
Wang K, Zhang C, Bao J, Jia X, Liang Y, Wang X, Chen M, Su H, Li P, Wan JB, He C
Scientific reports 2016 Jun 6;6:26064
Scientific reports 2016 Jun 6;6:26064
Dioscin Induces Apoptosis in Human Cervical Carcinoma HeLa and SiHa Cells through ROS-Mediated DNA Damage and the Mitochondrial Signaling Pathway.
Zhao X, Tao X, Xu L, Yin L, Qi Y, Xu Y, Han X, Peng J
Molecules (Basel, Switzerland) 2016 Jun 4;21(6)
Molecules (Basel, Switzerland) 2016 Jun 4;21(6)
Increased mitochondrial fission promotes autophagy and hepatocellular carcinoma cell survival through the ROS-modulated coordinated regulation of the NFKB and TP53 pathways.
Huang Q, Zhan L, Cao H, Li J, Lyu Y, Guo X, Zhang J, Ji L, Ren T, An J, Liu B, Nie Y, Xing J
Autophagy 2016 Jun 2;12(6):999-1014
Autophagy 2016 Jun 2;12(6):999-1014
The E545K mutation of PIK3CA promotes gallbladder carcinoma progression through enhanced binding to EGFR.
Zhao S, Cao Y, Liu SB, Wang XA, Bao RF, Shu YJ, Hu YP, Zhang YJ, Jiang L, Zhang F, Liang HB, Li HF, Ma Q, Xu Y, Wang Z, Zhang YC, Chen L, Zhou J, Liu YB
Journal of experimental & clinical cancer research : CR 2016 Jun 18;35(1):97
Journal of experimental & clinical cancer research : CR 2016 Jun 18;35(1):97
Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation.
Zhang W, Yin L, Tao X, Xu L, Zheng L, Han X, Xu Y, Wang C, Peng J
Environmental toxicology and pharmacology 2016 Jul;45:193-201
Environmental toxicology and pharmacology 2016 Jul;45:193-201
HDAC6 promotes cell proliferation and confers resistance to gefitinib in lung adenocarcinoma.
Wang Z, Tang F, Hu P, Wang Y, Gong J, Sun S, Xie C
Oncology reports 2016 Jul;36(1):589-97
Oncology reports 2016 Jul;36(1):589-97
Berberine in combination with cisplatin suppresses breast cancer cell growth through induction of DNA breaks and caspase-3-dependent apoptosis.
Zhao Y, Jing Z, Li Y, Mao W
Oncology reports 2016 Jul;36(1):567-72
Oncology reports 2016 Jul;36(1):567-72
Latcripin-13 domain induces apoptosis and cell cycle arrest at the G1 phase in human lung carcinoma A549 cells.
Wang J, Wan X, Gao Y, Zhong M, Sha L, Liu B, Zhang W, Tian L, Ruan W, Cao S, Huang M
Oncology reports 2016 Jul;36(1):441-7
Oncology reports 2016 Jul;36(1):441-7
MiRNA-203 suppresses cell proliferation, migration and invasion in colorectal cancer via targeting of EIF5A2.
Deng B, Wang B, Fang J, Zhu X, Cao Z, Lin Q, Zhou L, Sun X
Scientific reports 2016 Jul 4;6:28301
Scientific reports 2016 Jul 4;6:28301
Preventive Effects of a Novel Polysaccharide from Sepia esculenta Ink on Ovarian Failure and Its Action Mechanisms in Cyclophosphamide-Treated Mice.
Liu HZ, Tao YX, Luo P, Deng CM, Gu YP, Yang L, Zhong JP
Journal of agricultural and food chemistry 2016 Jul 20;64(28):5759-66
Journal of agricultural and food chemistry 2016 Jul 20;64(28):5759-66
Expression and prognostic role of ubiquitination factor E4B in primary hepatocellular carcinoma.
Zhang XF, Pan QZ, Pan K, Weng DS, Wang QJ, Zhao JJ, He J, Liu Q, Wang DD, Jiang SS, Zheng HX, Lv L, Chen CL, Zhang HX, Xia JC
Molecular carcinogenesis 2016 Jan;55(1):64-76
Molecular carcinogenesis 2016 Jan;55(1):64-76
Antitumor activity of ginseng sapogenins, 25-OH-PPD and 25-OCH3-PPD, on gastric cancer cells.
Zhao C, Su G, Wang X, Zhang X, Guo S, Zhao Y
Biotechnology letters 2016 Jan;38(1):43-50
Biotechnology letters 2016 Jan;38(1):43-50
Novel Recombinant Protein FlaA N/C Protects against Radiation Injury via NF-κB Signaling.
Xu Y, Wu D, Fan Y, Li P, Du H, Shi J, Wang D, Zhou X
Radiation research 2016 Jan;185(1):77-86
Radiation research 2016 Jan;185(1):77-86
Smac mimetic‑induced caspase‑independent necroptosis requires RIP1 in breast cancer.
Jin G, Lan Y, Han F, Sun Y, Liu Z, Zhang M, Liu X, Zhang X, Hu J, Liu H, Wang B
Molecular medicine reports 2016 Jan;13(1):359-66
Molecular medicine reports 2016 Jan;13(1):359-66
Anti-tumor activity of the TRPM8 inhibitor BCTC in prostate cancer DU145 cells.
Liu T, Fang Z, Wang G, Shi M, Wang X, Jiang K, Yang Z, Cao R, Tao H, Wang X, Zhou J
Oncology letters 2016 Jan;11(1):182-188
Oncology letters 2016 Jan;11(1):182-188
Overexpressed EDIL3 predicts poor prognosis and promotes anchorage-independent tumor growth in human pancreatic cancer.
Jiang SH, Wang Y, Yang JY, Li J, Feng MX, Wang YH, Yang XM, He P, Tian GA, Zhang XX, Li Q, Cao XY, Huo YM, Yang MW, Fu XL, Li J, Liu DJ, Dai M, Wen SY, Gu JR, Hong J, Hua R, Zhang ZG, Sun YW
Oncotarget 2016 Jan 26;7(4):4226-40
Oncotarget 2016 Jan 26;7(4):4226-40
SZC015, a synthetic oleanolic acid derivative, induces both apoptosis and autophagy in MCF-7 breast cancer cells.
Wu J, Yang C, Guo C, Li X, Yang N, Zhao L, Hang H, Liu S, Chu P, Sun Z, Sun B, Lin Y, Peng J, Han G, Wang S, Tang Z
Chemico-biological interactions 2016 Jan 25;244:94-104
Chemico-biological interactions 2016 Jan 25;244:94-104
Gamabufotalin, a major derivative of bufadienolide, inhibits VEGF-induced angiogenesis by suppressing VEGFR-2 signaling pathway.
Tang N, Shi L, Yu Z, Dong P, Wang C, Huo X, Zhang B, Huang S, Deng S, Liu K, Ma T, Wang X, Wu L, Ma XC
Oncotarget 2016 Jan 19;7(3):3533-47
Oncotarget 2016 Jan 19;7(3):3533-47
ROCK inhibitor Y27632 promotes proliferation and diminishes apoptosis of marmoset induced pluripotent stem cells by suppressing expression and activity of caspase 3.
Wu Y, Shu J, He C, Li M, Wang Y, Ou W, He Y
Theriogenology 2016 Jan 15;85(2):302-14
Theriogenology 2016 Jan 15;85(2):302-14
Oncogenic role of the TP53-induced glycolysis and apoptosis regulator in nasopharyngeal carcinoma through NF-κB pathway modulation.
Zhao M, Fan J, Liu Y, Yu Y, Xu J, Wen Q, Zhang J, Fu S, Wang B, Xiang L, Feng J, Wu J, Yang L
International journal of oncology 2016 Feb;48(2):756-64
International journal of oncology 2016 Feb;48(2):756-64
Effects of induced pluripotent stem cells-derived conditioned medium on the proliferation and anti-apoptosis of human adipose-derived stem cells.
Lian RL, Guo XL, Chen JS, Guo YL, Zheng JF, Chen YW
Molecular and cellular biochemistry 2016 Feb;413(1-2):69-85
Molecular and cellular biochemistry 2016 Feb;413(1-2):69-85
Anticancer effect of SZC017, a novel derivative of oleanolic acid, on human gastric cancer cells.
Gao L, Xu Z, Wang Y, Sun B, Song Z, Yang B, Liu X, Lin Y, Peng J, Han G, Wang S, Tang Z
Oncology reports 2016 Feb;35(2):1101-8
Oncology reports 2016 Feb;35(2):1101-8
Tectonic 1 Is a Key Regulator of Cell Proliferation in Pancreatic Cancer.
Zhao S, Chen X, Wan M, Jiang X, Li C, Cui Y, Kang P
Cancer biotherapy & radiopharmaceuticals 2016 Feb;31(1):7-13
Cancer biotherapy & radiopharmaceuticals 2016 Feb;31(1):7-13
CREB-binding protein regulates lung cancer growth by targeting MAPK and CPSF4 signaling pathway.
Tang Z, Yu W, Zhang C, Zhao S, Yu Z, Xiao X, Tang R, Xuan Y, Yang W, Hao J, Xu T, Zhang Q, Huang W, Deng W, Guo W
Molecular oncology 2016 Feb;10(2):317-29
Molecular oncology 2016 Feb;10(2):317-29
Polyphyllin VII induces apoptosis in HepG2 cells through ROS-mediated mitochondrial dysfunction and MAPK pathways.
Zhang C, Jia X, Bao J, Chen S, Wang K, Zhang Y, Li P, Wan JB, Su H, Wang Y, Mei Z, He C
BMC complementary and alternative medicine 2016 Feb 9;16:58
BMC complementary and alternative medicine 2016 Feb 9;16:58
Overexpression of RBM5 induces autophagy in human lung adenocarcinoma cells.
Su Z, Wang K, Li R, Yin J, Hao Y, Lv X, Li J, Zhao L, Du Y, Li P, Zhang J
World journal of surgical oncology 2016 Feb 29;14:57
World journal of surgical oncology 2016 Feb 29;14:57
The Protective Role of the TOPK/PBK Pathway in Myocardial Ischemia/Reperfusion and H₂O₂-Induced Injury in H9C2 Cardiomyocytes.
Sun G, Ye N, Dai D, Chen Y, Li C, Sun Y
International journal of molecular sciences 2016 Feb 23;17(3):267
International journal of molecular sciences 2016 Feb 23;17(3):267
Decreased TPD52 expression is associated with poor prognosis in primary hepatocellular carcinoma.
Wang Y, Chen CL, Pan QZ, Wu YY, Zhao JJ, Jiang SS, Chao J, Zhang XF, Zhang HX, Zhou ZQ, Tang Y, Huang XQ, Zhang JH, Xia JC
Oncotarget 2016 Feb 2;7(5):6323-34
Oncotarget 2016 Feb 2;7(5):6323-34
Apoptosis induction of dehydrobruceine B on two kinds of human lung cancer cell lines through mitochondrial-dependent pathway.
Zhao L, Wen Q, Yang G, Huang Z, Shen T, Li H, Ren D
Phytomedicine : international journal of phytotherapy and phytopharmacology 2016 Feb 15;23(2):114-22
Phytomedicine : international journal of phytotherapy and phytopharmacology 2016 Feb 15;23(2):114-22
β-elemene sensitizes hepatocellular carcinoma cells to oxaliplatin by preventing oxaliplatin-induced degradation of copper transporter 1.
Li X, Lin Z, Zhang B, Guo L, Liu S, Li H, Zhang J, Ye Q
Scientific reports 2016 Feb 12;6:21010
Scientific reports 2016 Feb 12;6:21010
ABT737 reverses cisplatin resistance by regulating ER-mitochondria Ca2+ signal transduction in human ovarian cancer cells.
Xie Q, Su J, Jiao B, Shen L, Ma L, Qu X, Yu C, Jiang X, Xu Y, Sun L
International journal of oncology 2016 Dec;49(6):2507-2519
International journal of oncology 2016 Dec;49(6):2507-2519
Naringin protects against lipopolysaccharide-induced cardiac injury in mice.
Xianchu L, Lan PZ, Qiufang L, Yi L, Xiangcheng R, Wenqi H, Yang D
Environmental toxicology and pharmacology 2016 Dec;48:1-6
Environmental toxicology and pharmacology 2016 Dec;48:1-6
Inhibition of tissue transglutaminase promotes Aβ-induced apoptosis in SH-SY5Y cells.
Zhang J, Ding YR, Wang R
Acta pharmacologica Sinica 2016 Dec;37(12):1534-1542
Acta pharmacologica Sinica 2016 Dec;37(12):1534-1542
Gefitinib enhances oxaliplatin-induced apoptosis mediated by Src and PKC-modulated gap junction function.
Wu JF, Ji J, Dong SY, Li BB, Yu ML, Wu DD, Tao L, Tong XH
Oncology reports 2016 Dec;36(6):3251-3258
Oncology reports 2016 Dec;36(6):3251-3258
PACE4 regulates apoptosis in human pancreatic cancer Panc‑1 cells via the mitochondrial signaling pathway.
Tian XF, Huang GM, Zang HL, Cao H
Molecular medicine reports 2016 Dec;14(6):5205-5210
Molecular medicine reports 2016 Dec;14(6):5205-5210
Anti-tumor effects of osthole on ovarian cancer cells in vitro.
Jiang G, Liu J, Ren B, Tang Y, Owusu L, Li M, Zhang J, Liu L, Li W
Journal of ethnopharmacology 2016 Dec 4;193:368-376
Journal of ethnopharmacology 2016 Dec 4;193:368-376
Triptolide Combined with Radiotherapy for the Treatment of Nasopharyngeal Carcinoma via NF-κB-Related Mechanism.
Zhang W, Kang M, Zhang T, Li B, Liao X, Wang R
International journal of molecular sciences 2016 Dec 19;17(12)
International journal of molecular sciences 2016 Dec 19;17(12)
VNN1 promotes atherosclerosis progression in apoE-/- mice fed a high-fat/high-cholesterol diet.
Hu YW, Wu SG, Zhao JJ, Ma X, Lu JB, Xiu JC, Zhang Y, Huang C, Qiu YR, Sha YH, Gao JJ, Wang YC, Li SF, Zhao JY, Zheng L, Wang Q
Journal of lipid research 2016 Aug;57(8):1398-411
Journal of lipid research 2016 Aug;57(8):1398-411
Hyperthermotherapy enhances antitumor effect of 5-aminolevulinic acid-mediated sonodynamic therapy with activation of caspase-dependent apoptotic pathway in human glioma.
Ju D, Yamaguchi F, Zhan G, Higuchi T, Asakura T, Morita A, Orimo H, Hu S
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Aug;37(8):10415-26
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Aug;37(8):10415-26
Potential implications of Apolipoprotein E in early brain injury after experimental subarachnoid hemorrhage: Involvement in the modulation of blood-brain barrier integrity.
Pang J, Wu Y, Peng J, Yang P, Kuai L, Qin X, Cao F, Sun X, Chen L, Vitek MP, Jiang Y
Oncotarget 2016 Aug 30;7(35):56030-56044
Oncotarget 2016 Aug 30;7(35):56030-56044
CD147 overexpression promotes tumorigenicity in Chinese hamster ovary cells.
Yong YL, Liao CG, Wei D, Chen ZN, Bian H
Cell biology international 2016 Apr;40(4):375-86
Cell biology international 2016 Apr;40(4):375-86
Puerarin ameliorates cognitive deficits in streptozotocin-induced diabetic rats.
Liu X, Mo Y, Gong J, Li Z, Peng H, Chen J, Wang Q, Ke Z, Xie J
Metabolic brain disease 2016 Apr;31(2):417-23
Metabolic brain disease 2016 Apr;31(2):417-23
Gadd45b prevents autophagy and apoptosis against rat cerebral neuron oxygen-glucose deprivation/reperfusion injury.
He G, Xu W, Tong L, Li S, Su S, Tan X, Li C
Apoptosis : an international journal on programmed cell death 2016 Apr;21(4):390-403
Apoptosis : an international journal on programmed cell death 2016 Apr;21(4):390-403
Shikonin induces apoptosis of HaCaT cells via the mitochondrial, Erk and Akt pathways.
Jing H, Sun W, Fan J, Zhang Y, Yang J, Jia J, Li J, Guo J, Luo S, Zheng Y
Molecular medicine reports 2016 Apr;13(4):3009-16
Molecular medicine reports 2016 Apr;13(4):3009-16
Protective effects of p-nitro caffeic acid phenethyl ester on acute myocardial ischemia-reperfusion injury in rats.
DU Q, Hao C, Gou J, Li X, Zou K, He X, Li Z
Experimental and therapeutic medicine 2016 Apr;11(4):1433-1440
Experimental and therapeutic medicine 2016 Apr;11(4):1433-1440
CARMA3 regulates the invasion, migration, and apoptosis of non-small cell lung cancer cells by activating NF-кB and suppressing the P38 MAPK signaling pathway.
Xia ZX, Li ZX, Zhang M, Sun LM, Zhang QF, Qiu XS
Experimental and molecular pathology 2016 Apr;100(2):353-60
Experimental and molecular pathology 2016 Apr;100(2):353-60
LncRNA-UCA1 enhances cell proliferation and 5-fluorouracil resistance in colorectal cancer by inhibiting miR-204-5p.
Bian Z, Jin L, Zhang J, Yin Y, Quan C, Hu Y, Feng Y, Liu H, Fei B, Mao Y, Zhou L, Qi X, Huang S, Hua D, Xing C, Huang Z
Scientific reports 2016 Apr 5;6:23892
Scientific reports 2016 Apr 5;6:23892
MED27 promotes melanoma growth by targeting AKT/MAPK and NF-κB/iNOS signaling pathways.
Tang R, Xu X, Yang W, Yu W, Hou S, Xuan Y, Tang Z, Zhao S, Chen Y, Xiao X, Huang W, Guo W, Li M, Deng W
Cancer letters 2016 Apr 1;373(1):77-87
Cancer letters 2016 Apr 1;373(1):77-87
PACE4 regulates apoptosis in human prostate cancer cells via endoplasmic reticulum stress and mitochondrial signaling pathways.
Yao Z, Sun B, Hong Q, Yan J, Mu D, Li J, Sheng H, Guo H
Drug design, development and therapy 2015;9:5911-23
Drug design, development and therapy 2015;9:5911-23
PCSK9 regulates apoptosis in human neuroglioma u251 cells via mitochondrial signaling pathways.
Piao MX, Bai JW, Zhang PF, Zhang YZ
International journal of clinical and experimental pathology 2015;8(3):2787-94
International journal of clinical and experimental pathology 2015;8(3):2787-94
Level of circulated microRNA-421 in gastric carcinoma and related mechanisms.
Zhao G, Xu L, Hui L, Zhao J
International journal of clinical and experimental pathology 2015;8(11):14252-6
International journal of clinical and experimental pathology 2015;8(11):14252-6
A comparison of the biological effects of 125I seeds continuous low-dose-rate radiation and 60Co high-dose-rate gamma radiation on non-small cell lung cancer cells.
Wang Z, Zhao Z, Lu J, Chen Z, Mao A, Teng G, Liu F
PloS one 2015;10(8):e0133728
PloS one 2015;10(8):e0133728
Matrine attenuates focal cerebral ischemic injury by improving antioxidant activity and inhibiting apoptosis in mice.
Zhao P, Zhou R, Zhu XY, Hao YJ, Li N, Wang J, Niu Y, Sun T, Li YX, Yu JQ
International journal of molecular medicine 2015 Sep;36(3):633-44
International journal of molecular medicine 2015 Sep;36(3):633-44
Alpha-Lipoic Acid Promotes Osteoblastic Formation in H2O2 -Treated MC3T3-E1 Cells and Prevents Bone Loss in Ovariectomized Rats.
Fu C, Xu D, Wang CY, Jin Y, Liu Q, Meng Q, Liu KX, Sun HJ, Liu MZ
Journal of cellular physiology 2015 Sep;230(9):2184-201
Journal of cellular physiology 2015 Sep;230(9):2184-201
Oxymatrine attenuated hypoxic-ischemic brain damage in neonatal rats via improving antioxidant enzyme activities and inhibiting cell death.
Zhao P, Zhou R, Li HN, Yao WX, Qiao HQ, Wang SJ, Niu Y, Sun T, Li YX, Yu JQ
Neurochemistry international 2015 Oct;89:17-27
Neurochemistry international 2015 Oct;89:17-27
17-Demethoxy-reblastatin, an Hsp90 inhibitor, induces mitochondria-mediated apoptosis through downregulation of Mcl-1 in human hepatocellular carcinoma cells.
Zhao S, Li H, Jiang C, Ma T, Wu C, Huo Q, Liu H
Journal of bioenergetics and biomembranes 2015 Oct;47(5):373-81
Journal of bioenergetics and biomembranes 2015 Oct;47(5):373-81
Cold-inducible RNA-binding protein inhibits neuron apoptosis through the suppression of mitochondrial apoptosis.
Zhang HT, Xue JH, Zhang ZW, Kong HB, Liu AJ, Li SC, Xu DG
Brain research 2015 Oct 5;1622:474-83
Brain research 2015 Oct 5;1622:474-83
Protein kinase CK2α catalytic subunit is overexpressed and serves as an unfavorable prognostic marker in primary hepatocellular carcinoma.
Zhang HX, Jiang SS, Zhang XF, Zhou ZQ, Pan QZ, Chen CL, Zhao JJ, Tang Y, Xia JC, Weng DS
Oncotarget 2015 Oct 27;6(33):34800-17
Oncotarget 2015 Oct 27;6(33):34800-17
BPTF promotes tumor growth and predicts poor prognosis in lung adenocarcinomas.
Dai M, Lu JJ, Guo W, Yu W, Wang Q, Tang R, Tang Z, Xiao Y, Li Z, Sun W, Sun X, Qin Y, Huang W, Deng WG, Wu T
Oncotarget 2015 Oct 20;6(32):33878-92
Oncotarget 2015 Oct 20;6(32):33878-92
MicroRNA‑328 directly targets p21‑activated protein kinase 6 inhibiting prostate cancer proliferation and enhancing docetaxel sensitivity.
Liu C, Zhang L, Huang Y, Lu K, Tao T, Chen S, Zhang X, Guan H, Chen M, Xu B
Molecular medicine reports 2015 Nov;12(5):7389-95
Molecular medicine reports 2015 Nov;12(5):7389-95
Pseudolaric acid B inhibits proliferation in SW579 human thyroid squamous cell carcinoma.
Yu J, Ren P, Zhong T, Wang Y, Yan M, Xue B, Li R, Dai C, Liu C, Chen G, Yu XF
Molecular medicine reports 2015 Nov;12(5):7195-202
Molecular medicine reports 2015 Nov;12(5):7195-202
Quercetin reverses experimental pulmonary arterial hypertension by modulating the TrkA pathway.
He Y, Cao X, Liu X, Li X, Xu Y, Liu J, Shi J
Experimental cell research 2015 Nov 15;339(1):122-34
Experimental cell research 2015 Nov 15;339(1):122-34
Bortezomib-mediated down-regulation of telomerase and disruption of telomere homeostasis contributes to apoptosis of malignant cells.
Ci X, Li B, Ma X, Kong F, Zheng C, Björkholm M, Jia J, Xu D
Oncotarget 2015 Nov 10;6(35):38079-92
Oncotarget 2015 Nov 10;6(35):38079-92
Progranulin protects against renal ischemia/reperfusion injury in mice.
Zhou M, Tang W, Fu Y, Xu X, Wang Z, Lu Y, Liu F, Yang X, Wei X, Zhang Y, Liu J, Geng X, Zhang C, Wan Q, Li N, Yi F
Kidney international 2015 May;87(5):918-29
Kidney international 2015 May;87(5):918-29
RASSF10 suppresses hepatocellular carcinoma growth by activating P53 signaling and methylation of RASSF10 is a docetaxel resistant marker.
Jin Y, Cao B, Zhang M, Zhan Q, Herman JG, Yu M, Guo M
Genes & cancer 2015 May;6(5-6):231-40
Genes & cancer 2015 May;6(5-6):231-40
miRNA-1207-5p is associated with cancer progression by targeting stomatin-like protein 2 in esophageal carcinoma.
Yang X, Zang W, Xuan X, Wang Z, Liu Z, Wang J, Cui J, Zhao G
International journal of oncology 2015 May;46(5):2163-71
International journal of oncology 2015 May;46(5):2163-71
Effects of ghrelin on postresuscitation brain injury in a rat model of cardiac arrest.
Xie X, Zhang J, Chen D, Pan H, Wu Z, Ge D, Yang G
Shock (Augusta, Ga.) 2015 May;43(5):490-6
Shock (Augusta, Ga.) 2015 May;43(5):490-6
Pretreatment with low dose etomidate prevents etomidate-induced rat adrenal insufficiency by regulating oxidative stress-related MAPKs and apoptosis.
Liu S, Zhang XP, Han NN, Lv S, Xiong JY
Environmental toxicology and pharmacology 2015 May;39(3):1212-20
Environmental toxicology and pharmacology 2015 May;39(3):1212-20
By reducing hexokinase 2, resveratrol induces apoptosis in HCC cells addicted to aerobic glycolysis and inhibits tumor growth in mice.
Dai W, Wang F, Lu J, Xia Y, He L, Chen K, Li J, Li S, Liu T, Zheng Y, Wang J, Lu W, Zhou Y, Yin Q, Abudumijiti H, Chen R, Zhang R, Zhou L, Zhou Z, Zhu R, Yang J, Wang C, Zhang H, Zhou Y, Xu L, Guo C
Oncotarget 2015 May 30;6(15):13703-17
Oncotarget 2015 May 30;6(15):13703-17
An ESRG-interacting protein, COXII, is involved in pro-apoptosis of human embryonic stem cells.
Shi J, Ren C, Liu H, Wang L, Zhu B, Huang W, Liu W, Liu J, Liu Y, Xia X, Xu R, Jiang X
Biochemical and biophysical research communications 2015 May 1;460(2):130-5
Biochemical and biophysical research communications 2015 May 1;460(2):130-5
Novel taspine derivative 12k inhibits cell growth and induces apoptosis in lung cell carcinoma.
Dai B, Wang W, Liu R, Wang H, Zhang Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2015 Mar;70:227-33
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2015 Mar;70:227-33
Enantioselective apoptosis induced by individual isomers of bifenthrin in Hep G2 cells.
Liu H, Li J
Environmental toxicology and pharmacology 2015 Mar;39(2):810-4
Environmental toxicology and pharmacology 2015 Mar;39(2):810-4
Effect of baicalin-copper on the induction of apoptosis in human hepatoblastoma cancer HepG2 cells.
Li X, Zou K, Gou J, Du Q, Li D, He X, Li Z
Medical oncology (Northwood, London, England) 2015 Mar;32(3):72
Medical oncology (Northwood, London, England) 2015 Mar;32(3):72
Bcl-2 phosphorylation triggers autophagy switch and reduces mitochondrial damage in limb remote ischemic conditioned rats after ischemic stroke.
Qi Z, Dong W, Shi W, Wang R, Zhang C, Zhao Y, Ji X, Liu KJ, Luo Y
Translational stroke research 2015 Jun;6(3):198-206
Translational stroke research 2015 Jun;6(3):198-206
A new dimeric neolignan from Magnolia grandiflora L. seeds.
Li HM, Zhao SR, Huo Q, Ma T, Liu H, Lee JK, Hong YS, Wu CZ
Archives of pharmacal research 2015 Jun;38(6):1066-71
Archives of pharmacal research 2015 Jun;38(6):1066-71
Tetrachlorobenzoquinone triggers the cleavage of Bid and promotes the cross-talk of extrinsic and intrinsic apoptotic signalings in pheochromocytoma (PC) 12 cells.
Hu L, Su C, Song X, Shi Q, Fu J, Xia X, Xu D, Song E, Song Y
Neurotoxicology 2015 Jul;49:149-57
Neurotoxicology 2015 Jul;49:149-57
Flotillin-2 promotes metastasis of nasopharyngeal carcinoma by activating NF-κB and PI3K/Akt3 signaling pathways.
Liu J, Huang W, Ren C, Wen Q, Liu W, Yang X, Wang L, Zhu B, Zeng L, Feng X, Zhang C, Chen H, Jia W, Zhang L, Xia X, Chen Y
Scientific reports 2015 Jul 24;5:11614
Scientific reports 2015 Jul 24;5:11614
Expression profile of apoptotic and proliferative proteins in hypoxic HUVEC treated with statins.
Li X, Liu X, Xu Y, He Y, Liu J, Xie M
International journal of oncology 2015 Feb;46(2):677-84
International journal of oncology 2015 Feb;46(2):677-84
SZC017, a novel oleanolic acid derivative, induces apoptosis and autophagy in human breast cancer cells.
Gao L, Wang Y, Xu Z, Li X, Wu J, Liu S, Chu P, Sun Z, Sun B, Lin Y, Peng J, Han G, Wang S, Tang Z
Apoptosis : an international journal on programmed cell death 2015 Dec;20(12):1636-50
Apoptosis : an international journal on programmed cell death 2015 Dec;20(12):1636-50
Phosphocreatine protects endothelial cells from oxidized low-density lipoprotein-induced apoptosis by modulating the PI3K/Akt/eNOS pathway.
Ahsan A, Han G, Pan J, Liu S, Padhiar AA, Chu P, Sun Z, Zhang Z, Sun B, Wu J, Irshad A, Lin Y, Peng J, Tang Z
Apoptosis : an international journal on programmed cell death 2015 Dec;20(12):1563-76
Apoptosis : an international journal on programmed cell death 2015 Dec;20(12):1563-76
O-Alkylated derivatives of quercetin induce apoptosis of MCF-7 cells via a caspase-independent mitochondrial pathway.
Liao H, Bao X, Zhu J, Qu J, Sun Y, Ma X, Wang E, Guo X, Kang Q, Zhen Y
Chemico-biological interactions 2015 Dec 5;242:91-8
Chemico-biological interactions 2015 Dec 5;242:91-8
Optimization of intrinsic and extrinsic tendon healing through controllable water-soluble mitomycin-C release from electrospun fibers by mediating adhesion-related gene expression.
Zhao X, Jiang S, Liu S, Chen S, Lin ZY, Pan G, He F, Li F, Fan C, Cui W
Biomaterials 2015 Aug;61:61-74
Biomaterials 2015 Aug;61:61-74
Ginsenoside Rg3 suppresses FUT4 expression through inhibiting NF-κB/p65 signaling pathway to promote melanoma cell death.
Shan X, Tian LL, Zhang YM, Wang XQ, Yan Q, Liu JW
International journal of oncology 2015 Aug;47(2):701-9
International journal of oncology 2015 Aug;47(2):701-9
CXCR1/2 antagonism with CXCL8/Interleukin-8 analogue CXCL8(3-72)K11R/G31P restricts lung cancer growth by inhibiting tumor cell proliferation and suppressing angiogenesis.
Khan MN, Wang B, Wei J, Zhang Y, Li Q, Luan X, Cheng JW, Gordon JR, Li F, Liu H
Oncotarget 2015 Aug 28;6(25):21315-27
Oncotarget 2015 Aug 28;6(25):21315-27
Antifibrotic effects of luteolin on hepatic stellate cells and liver fibrosis by targeting AKT/mTOR/p70S6K and TGFβ/Smad signalling pathways.
Li J, Li X, Xu W, Wang S, Hu Z, Zhang Q, Deng X, Wang J, Zhang J, Guo C
Liver international : official journal of the International Association for the Study of the Liver 2015 Apr;35(4):1222-33
Liver international : official journal of the International Association for the Study of the Liver 2015 Apr;35(4):1222-33
DLC-1 induces mitochondrial apoptosis and epithelial mesenchymal transition arrest in nasopharyngeal carcinoma by targeting EGFR/Akt/NF-κB pathway.
Huang W, Liu J, Feng X, Chen H, Zeng L, Huang G, Liu W, Wang L, Jia W, Chen J, Ren C
Medical oncology (Northwood, London, England) 2015 Apr;32(4):115
Medical oncology (Northwood, London, England) 2015 Apr;32(4):115
Potent effects of dioscin against liver fibrosis.
Zhang X, Han X, Yin L, Xu L, Qi Y, Xu Y, Sun H, Lin Y, Liu K, Peng J
Scientific reports 2015 Apr 8;5:9713
Scientific reports 2015 Apr 8;5:9713
Trichostatin A targets the mitochondrial respiratory chain, increasing mitochondrial reactive oxygen species production to trigger apoptosis in human breast cancer cells.
Sun S, Han Y, Liu J, Fang Y, Tian Y, Zhou J, Ma D, Wu P
PloS one 2014;9(3):e91610
PloS one 2014;9(3):e91610
Lycium barbarum polysaccharide prevents focal cerebral ischemic injury by inhibiting neuronal apoptosis in mice.
Wang T, Li Y, Wang Y, Zhou R, Ma L, Hao Y, Jin S, Du J, Zhao C, Sun T, Yu J
PloS one 2014;9(3):e90780
PloS one 2014;9(3):e90780
Lycium barbarum polysaccharides protect human lens epithelial cells against oxidative stress-induced apoptosis and senescence.
Qi B, Ji Q, Wen Y, Liu L, Guo X, Hou G, Wang G, Zhong J
PloS one 2014;9(10):e110275
PloS one 2014;9(10):e110275
PNMA1 promotes cell growth in human pancreatic ductal adenocarcinoma.
Jiang SH, He P, Ma MZ, Wang Y, Li RK, Fang F, Fu Y, Tian GA, Qin WX, Zhang ZG
International journal of clinical and experimental pathology 2014;7(7):3827-35
International journal of clinical and experimental pathology 2014;7(7):3827-35
mTOR inhibitor AZD8055 inhibits proliferation and induces apoptosis in laryngeal carcinoma.
Zhao L, Teng B, Wen L, Feng Q, Wang H, Li N, Wang Y, Liang Z
International journal of clinical and experimental medicine 2014;7(2):337-47
International journal of clinical and experimental medicine 2014;7(2):337-47
The proapoptotic effect of formononetin in human osteosarcoma cells: involvement of inactivation of ERK and Akt pathways.
Liu Y, He J, Chen X, Li J, Shen M, Yu W, Yang Y, Xiao Z
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2014;34(3):637-45
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2014;34(3):637-45
14-Thienyl methylene matrine (YYJ18), the derivative from matrine, induces apoptosis of human nasopharyngeal carcinoma cells by targeting MAPK and PI3K/Akt pathways in vitro.
Xie M, Yi X, Wang R, Wang L, He G, Zhu M, Qi C, Liu Y, Ye Y, Tan S, Tang A
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2014;33(5):1475-83
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2014;33(5):1475-83
Naringin inhibits TNF-α induced oxidative stress and inflammatory response in HUVECs via Nox4/NF-κ B and PI3K/Akt pathways.
Li W, Wang C, Peng J, Liang J, Jin Y, Liu Q, Meng Q, Liu K, Sun H
Current pharmaceutical biotechnology 2014;15(12):1173-82
Current pharmaceutical biotechnology 2014;15(12):1173-82
The mitochondrial thioredoxin is required for liver development in zebrafish.
Zhang J, Cui X, Wang L, Liu F, Jiang T, Li C, Li D, Huang M, Liao S, Wang J, Chen J, Jia H, He J, Tang Z, Yin Z, Liu M
Current molecular medicine 2014;14(6):772-82
Current molecular medicine 2014;14(6):772-82
Dioscin attenuates hepatic ischemia-reperfusion injury in rats through inhibition of oxidative-nitrative stress, inflammation and apoptosis.
Tao X, Wan X, Xu Y, Xu L, Qi Y, Yin L, Han X, Lin Y, Peng J
Transplantation 2014 Sep 27;98(6):604-11
Transplantation 2014 Sep 27;98(6):604-11
Galectin-3 is associated with a poor prognosis in primary hepatocellular carcinoma.
Jiang SS, Weng DS, Wang QJ, Pan K, Zhang YJ, Li YQ, Li JJ, Zhao JJ, He J, Lv L, Pan QZ, Xia JC
Journal of translational medicine 2014 Sep 27;12:273
Journal of translational medicine 2014 Sep 27;12:273
Tetrachloro-p-benzoquinone induces hepatic oxidative damage and inflammatory response, but not apoptosis in mouse: the prevention of curcumin.
Xu D, Hu L, Su C, Xia X, Zhang P, Fu J, Wang W, Xu D, Du H, Hu Q, Song E, Song Y
Toxicology and applied pharmacology 2014 Oct 15;280(2):305-13
Toxicology and applied pharmacology 2014 Oct 15;280(2):305-13
miR-203a regulates proliferation, migration, and apoptosis by targeting glycogen synthase kinase-3β in human renal cell carcinoma.
Hu G, Lai P, Liu M, Xu L, Guo Z, Liu H, Li W, Wang G, Yao X, Zheng J, Xu Y
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2014 Nov;35(11):11443-53
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2014 Nov;35(11):11443-53
Endoplasmic reticulum stress is involved in restraint stress-induced hippocampal apoptosis and cognitive impairments in rats.
Zhang Y, Liu W, Zhou Y, Ma C, Li S, Cong B
Physiology & behavior 2014 May 28;131:41-8
Physiology & behavior 2014 May 28;131:41-8
Chemical characterization and antitumor activities of polysaccharide extracted from Ganoderma lucidum.
Liang Z, Yi Y, Guo Y, Wang R, Hu Q, Xiong X
International journal of molecular sciences 2014 May 22;15(5):9103-16
International journal of molecular sciences 2014 May 22;15(5):9103-16
Interplay between the Notch and PI3K/Akt pathways in high glucose-induced podocyte apoptosis.
Wang XM, Yao M, Liu SX, Hao J, Liu QJ, Gao F
American journal of physiology. Renal physiology 2014 Jan;306(2):F205-13
American journal of physiology. Renal physiology 2014 Jan;306(2):F205-13
Dioscin-induced apoptosis of human LNCaP prostate carcinoma cells through activation of caspase-3 and modulation of Bcl-2 protein family.
Chen J, Li HM, Zhang XN, Xiong CM, Ruan JL
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2014 Feb;34(1):125-130
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2014 Feb;34(1):125-130
Ubiquitin‑specific protease 22‑induced autophagy is correlated with poor prognosis of pancreatic cancer.
Liang JX, Ning Z, Gao W, Ling J, Wang AM, Luo HF, Liang Y, Yan Q, Wang ZY
Oncology reports 2014 Dec;32(6):2726-34
Oncology reports 2014 Dec;32(6):2726-34
Galangin inhibits growth of human head and neck squamous carcinoma cells in vitro and in vivo.
Zhu L, Luo Q, Bi J, Ding J, Ge S, Chen F
Chemico-biological interactions 2014 Dec 5;224:149-56
Chemico-biological interactions 2014 Dec 5;224:149-56
Potentiation of paclitaxel activity by curcumin in human breast cancer cell by modulating apoptosis and inhibiting EGFR signaling.
Zhan Y, Chen Y, Liu R, Zhang H, Zhang Y
Archives of pharmacal research 2014 Aug;37(8):1086-95
Archives of pharmacal research 2014 Aug;37(8):1086-95
MicroRNA-206 overexpression promotes apoptosis, induces cell cycle arrest and inhibits the migration of human hepatocellular carcinoma HepG2 cells.
Liu W, Xu C, Wan H, Liu C, Wen C, Lu H, Wan F
International journal of molecular medicine 2014 Aug;34(2):420-8
International journal of molecular medicine 2014 Aug;34(2):420-8
Potent effects of flavonoid-rich extract from Rosa laevigata Michx fruit against hydrogen peroxide-induced damage in PC12 cells via attenuation of oxidative stress, inflammation and apoptosis.
Liu M, Xu Y, Han X, Liang C, Yin L, Xu L, Qi Y, Zhao Y, Peng J, Sun C
Molecules (Basel, Switzerland) 2014 Aug 7;19(8):11816-32
Molecules (Basel, Switzerland) 2014 Aug 7;19(8):11816-32
Puerarin protected the brain from cerebral ischemia injury via astrocyte apoptosis inhibition.
Wang N, Zhang Y, Wu L, Wang Y, Cao Y, He L, Li X, Zhao J
Neuropharmacology 2014 Apr;79:282-9
Neuropharmacology 2014 Apr;79:282-9
Sine oculis homeobox homolog 1 promotes α5β1-mediated invasive migration and metastasis of cervical cancer cells.
Liu D, Zhang XX, Wan DY, Xi BX, Ma D, Wang H, Gao QL
Biochemical and biophysical research communications 2014 Apr 4;446(2):549-54
Biochemical and biophysical research communications 2014 Apr 4;446(2):549-54
Dioscin promotes osteoblastic proliferation and differentiation via Lrp5 and ER pathway in mouse and human osteoblast-like cell lines.
Zhang C, Peng J, Wu S, Jin Y, Xia F, Wang C, Liu K, Sun H, Liu M
Journal of biomedical science 2014 Apr 17;21(1):30
Journal of biomedical science 2014 Apr 17;21(1):30
Anti-cancer effects of dioscin on three kinds of human lung cancer cell lines through inducing DNA damage and activating mitochondrial signal pathway.
Wei Y, Xu Y, Han X, Qi Y, Xu L, Xu Y, Yin L, Sun H, Liu K, Peng J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2013 Sep;59:118-28
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2013 Sep;59:118-28
The protective effect of Cold-inducible RNA-binding protein (CIRP) on testicular torsion/detorsion: an experimental study in mice.
Xia Z, Jiang K, Liu T, Zheng H, Liu X, Zheng X
Journal of pediatric surgery 2013 Oct;48(10):2140-7
Journal of pediatric surgery 2013 Oct;48(10):2140-7
Administration of cathepsin B inhibitor CA-074Me reduces inflammation and apoptosis in polymyositis.
Feng Y, Ni L, Wang Q
Journal of dermatological science 2013 Nov;72(2):158-67
Journal of dermatological science 2013 Nov;72(2):158-67
Protective effect of flavonoid-rich extract from Rosa laevigata Michx on cerebral ischemia-reperfusion injury through suppression of apoptosis and inflammation.
Zhang S, Qi Y, Xu Y, Han X, Peng J, Liu K, Sun CK
Neurochemistry international 2013 Nov;63(5):522-32
Neurochemistry international 2013 Nov;63(5):522-32
PPARγ mediates the effects of WIN55,212-2, an synthetic cannabinoid, on the proliferation and apoptosis of the BEL-7402 hepatocarcinoma cells.
Hong Y, Zhou Y, Wang Y, Xiao S, Liao DJ, Zhao Q
Molecular biology reports 2013 Nov;40(11):6287-93
Molecular biology reports 2013 Nov;40(11):6287-93
Oxysophoridine protects against focal cerebral ischemic injury by inhibiting oxidative stress and apoptosis in mice.
Wang TF, Lei Z, Li YX, Wang YS, Wang J, Wang SJ, Hao YJ, Zhou R, Jin SJ, Du J, Li J, Sun T, Yu JQ
Neurochemical research 2013 Nov;38(11):2408-17
Neurochemical research 2013 Nov;38(11):2408-17
Synergistic anti-glioma effect of Hydroxygenkwanin and Apigenin in vitro.
Wang Y, Xu YS, Yin LH, Xu LN, Peng JY, Zhou H, Kang W
Chemico-biological interactions 2013 Nov 25;206(2):346-55
Chemico-biological interactions 2013 Nov 25;206(2):346-55
Notch pathway is involved in high glucose-induced apoptosis in podocytes via Bcl-2 and p53 pathways.
Gao F, Yao M, Shi Y, Hao J, Ren Y, Liu Q, Wang X, Duan H
Journal of cellular biochemistry 2013 May;114(5):1029-38
Journal of cellular biochemistry 2013 May;114(5):1029-38
Hepatitis B viral RNA directly mediates down-regulation of the tumor suppressor microRNA miR-15a/miR-16-1 in hepatocytes.
Wang Y, Jiang L, Ji X, Yang B, Zhang Y, Fu XD
The Journal of biological chemistry 2013 Jun 21;288(25):18484-93
The Journal of biological chemistry 2013 Jun 21;288(25):18484-93
Notch1 signaling contributes to the oncogenic effect of HBx on human hepatic cells.
Wang F, Xia X, Wang J, Sun Q, Luo J, Cheng B
Biotechnology letters 2013 Jan;35(1):29-37
Biotechnology letters 2013 Jan;35(1):29-37
Cathepsin L stimulates autophagy and inhibits apoptosis of ox-LDL-induced endothelial cells: potential role in atherosclerosis.
Wei DH, Jia XY, Liu YH, Guo FX, Tang ZH, Li XH, Wang Z, Liu LS, Wang GX, Jian ZS, Ruan CG
International journal of molecular medicine 2013 Feb;31(2):400-6
International journal of molecular medicine 2013 Feb;31(2):400-6
Emodin regulates apoptotic pathway in human liver cancer cells.
Yu JQ, Bao W, Lei JC
Phytotherapy research : PTR 2013 Feb;27(2):251-7
Phytotherapy research : PTR 2013 Feb;27(2):251-7
Chemical composition of total flavonoids from Salvia chinensia Benth and their pro-apoptotic effect on hepatocellular carcinoma cells: potential roles of suppressing cellular NF-κB signaling.
Xiang M, Su H, Hu Y, Hu Y, Yang T, Shu G
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2013 Dec;62:420-6
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2013 Dec;62:420-6
Protective effects of the total saponins from Rosa laevigata Michx fruit against carbon tetrachloride-induced acute liver injury in mice.
Dong D, Zhang S, Yin L, Tang X, Xu Y, Han X, Qi Y, Peng J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2013 Dec;62:120-30
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2013 Dec;62:120-30
Expression and role of grainyhead-like 2 in gastric cancer.
Xiang J, Fu X, Ran W, Chen X, Hang Z, Mao H, Wang Z
Medical oncology (Northwood, London, England) 2013 Dec;30(4):714
Medical oncology (Northwood, London, England) 2013 Dec;30(4):714
Neuroprotective effect of Danshensu derivatives as anti-ischaemia agents on SH-SY5Y cells and rat brain.
Seetapun S, Yaoling J, Wang Y, Zhu YZ
Bioscience reports 2013 Aug 30;33(4)
Bioscience reports 2013 Aug 30;33(4)
The synthesis and biological evaluation of novel Danshensu-cysteine analog conjugates as cardiovascular-protective agents.
Jia Y, Dong X, Zhou P, Liu X, Pan L, Xin H, Zhu YZ, Wang Y
European journal of medicinal chemistry 2012 Sep;55:176-87
European journal of medicinal chemistry 2012 Sep;55:176-87
Alantolactone induces activation of apoptosis in human hepatoma cells.
Lei JC, Yu JQ, Yin Y, Liu YW, Zou GL
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2012 Sep;50(9):3313-9
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2012 Sep;50(9):3313-9
Total flavonoids from Rosa Laevigata Michx fruit attenuates hydrogen peroxide induced injury in human umbilical vein endothelial cells.
Jia Y, Ji L, Zhang S, Xu L, Yin L, Li L, Zhao Y, Peng J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2012 Sep;50(9):3133-41
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2012 Sep;50(9):3133-41
Nestin protects mouse podocytes against high glucose-induced apoptosis by a Cdk5-dependent mechanism.
Liu W, Zhang Y, Hao J, Liu S, Liu Q, Zhao S, Shi Y, Duan H
Journal of cellular biochemistry 2012 Oct;113(10):3186-96
Journal of cellular biochemistry 2012 Oct;113(10):3186-96
Autophagy-related gene 7 (ATG7) and reactive oxygen species/extracellular signal-regulated kinase regulate tetrandrine-induced autophagy in human hepatocellular carcinoma.
Gong K, Chen C, Zhan Y, Chen Y, Huang Z, Li W
The Journal of biological chemistry 2012 Oct 12;287(42):35576-35588
The Journal of biological chemistry 2012 Oct 12;287(42):35576-35588
Role of mitochondrial pathway in compression-induced apoptosis of nucleus pulposus cells.
Ding F, Shao ZW, Yang SH, Wu Q, Gao F, Xiong LM
Apoptosis : an international journal on programmed cell death 2012 Jun;17(6):579-90
Apoptosis : an international journal on programmed cell death 2012 Jun;17(6):579-90
Activation of apoptosis by ethyl acetate fraction of ethanol extract of Dianthus superbus in HepG2 cell line.
Yu JQ, Yin Y, Lei JC, Zhang XQ, Chen W, Ding CL, Wu S, He XY, Liu YW, Zou GL
Cancer epidemiology 2012 Feb;36(1):e40-5
Cancer epidemiology 2012 Feb;36(1):e40-5
Putative tumor suppressor miR-145 inhibits colon cancer cell growth by targeting oncogene Friend leukemia virus integration 1 gene.
Zhang J, Guo H, Zhang H, Wang H, Qian G, Fan X, Hoffman AR, Hu JF, Ge S
Cancer 2011 Jan 1;117(1):86-95
Cancer 2011 Jan 1;117(1):86-95
NF-κB, JNK and p53 pathways are involved in tubeimoside-1-induced apoptosis in HepG2 cells with oxidative stress and G₂/M cell cycle arrest.
Yin Y, Chen W, Tang C, Ding H, Jang J, Weng M, Cai Y, Zou G
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2011 Dec;49(12):3046-54
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2011 Dec;49(12):3046-54
Enantioselective cytotoxicity of isocarbophos is mediated by oxidative stress-induced JNK activation in human hepatocytes.
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HL-60 cells were subjected to SDS PAGE followed by western blot with 12789-1-AP(BCL2 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-BCL2 (IP:12789-1-AP, 3ug; Detection:12789-1-AP 1:1000) with MCF-7 cells lysate 2500ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 12789-1-AP(BCL2 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human breast cancer using 12789-1-AP(BCL2 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The BCL2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human BCL2. This antibody recognizes human antigen. The BCL2 antibody has been validated for the following applications: ELISA, WB, IP, IHC analysis.
