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- Antibody Data
- Antigen structure
- References [282]
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- Product number
- 60178-1-Ig - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#60178-1-Ig, RRID:AB_10734459
- Product name
- BCL2 antibody
- Antibody type
- Monoclonal
- Description
- KD/KO validated BCL2 antibody (Cat. #60178-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, pig and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Porcine
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 4H8C6
- Vial size
- 20ul, 150ul
Submitted references Metformin alleviates lung ischemia-reperfusion injury in a rat lung transplantation model.
Knockdown of programmed cell death factor 4 restores erectile function by attenuating apoptosis in rats with bilateral cavernous nerve crush injury.
Promotion of apoptosis in melanoma cells by taxifolin through the PI3K/AKT signaling pathway: Screening of natural products using WGCNA and CMAP platforms.
Untargeted serum and gastric metabolomics and network pharmacology analysis reveal the superior efficacy of zingiberis rhizoma recens-/euodiae fructus-processed Coptidis Rhizoma on gastric ulcer rats.
Carnosol alleviates sepsis-induced pulmonary endothelial barrier dysfunction by targeting nuclear factor erythroid2-related factor 2/sirtuin-3 signaling pathway to attenuate oxidative damage.
Human umbilical cord mesenchymal stem cell-derived exosomal miR-214-3p regulates the progression of gallbladder cancer by regulating ACLY/GLUT1.
Identification of immunogenic cell death-related damage-related molecular patterns (DAMPs) to predict outcomes in patients with head and neck squamous cell carcinoma.
Neuroprotective effects of apigenin on retinal ganglion cells in ischemia/reperfusion: modulating mitochondrial dynamics in in vivo and in vitro models.
PPP2R2A inhibition contributes to preeclampsia by regulating the proliferation, apoptosis, and angiogenesis modulation potential of mesenchymal stem cells.
VHL suppresses autophagy and tumor growth through PHD1-dependent Beclin1 hydroxylation.
High expression of B7-H3 on monocyte/macrophages in tumor microenvironment promotes lung cancer progression by inhibiting apoptosis.
A decrease in integrin α5β1/FAK is associated with increased apoptosis of aortic smooth muscle cells in acute type a aortic dissection.
Ubiquitinome Analysis Uncovers Alterations in Synaptic Proteins and Glucose Metabolism Enzymes in the Hippocampi of Adolescent Mice Following Cold Exposure.
Mechanisms of intermittent theta-burst stimulation attenuating nerve injury after ischemic reperfusion in rats through endoplasmic reticulum stress and ferroptosis.
Effect of black cloth ointment on hypertrophic scar formation: An investigation using integrated network pharmacology and animal assay.
Downregulation of SMAD4 protects HaCaT cells against UVB-induced damage and oxidative stress through the activation of EMT.
Delivery of exogenous miR-19b by Wharton's Jelly Mesenchymal Stem Cells attenuates transplanted kidney ischemia/reperfusion injury by regulating cellular metabolism.
Chidamide enhances T-cell-mediated anti-tumor immune function by inhibiting NOTCH1/NFATC1 signaling pathway in ABC-type diffuse large B-cell lymphoma.
Calcitonin gene‑related peptide alleviates hyperoxia‑induced human alveolar cell injury via the CGRPR/TRPV1/Ca2(+) axis.
FUDNC1-dependent mitophagy ameliorate motor neuron death in an amyotrophic lateral sclerosis mouse model.
Hematoporphyrin derivative photodynamic therapy induces apoptosis and suppresses the migration of human esophageal squamous cell carcinoma cells by regulating the PI3K/AKT/mTOR signaling pathway.
Argininyl-Fructosyl-Galactose: A Novel Amino Acid Derivative improves Cisplatin-induced Intestinal Toxicity via Reactive Oxygen Species- mediated Apoptosis Pathway.
METTL1 mediated tRNA m(7)G modification promotes leukaemogenesis of AML via tRNA regulated translational control.
Loganin protects against myocardial ischemia-reperfusion injury by modulating oxidative stress and cellular apoptosis via activation of JAK2/STAT3 signaling.
Chemoproteomics Reveals Glaucocalyxin A Induces Mitochondria-Dependent Apoptosis of Leukemia Cells via Covalently Binding to VDAC1.
A study on the role of Taxifolin in inducing apoptosis of pancreatic cancer cells: screening results using weighted gene co-expression network analysis.
The effects of anti-lung cancer in nude mice by a fully human single-chain antibody against associated antigen Ts7TMR between A549 cells and Trichinella spiralis.
The combination of Butyricicoccus pullicaecorum and 3-hydroxyanthranilic acid prevents postmenopausal osteoporosis by modulating gut microbiota and Th17/Treg.
Corynoxine triggers cell death via activating PP2A and regulating AKT-mTOR/GSK3β axes in NSCLC.
Treadmill training improves lung function and inhibits alveolar cell apoptosis in spinal cord injured rats.
Transcutaneous Electrical Nerve Stimulation (TENS) Alleviates Brain Ischemic Injury by Regulating Neuronal Oxidative Stress, Pyroptosis, and Mitophagy.
Extracellular vesicles carrying miR-6836 derived from resistant tumor cells transfer cisplatin resistance of epithelial ovarian cancer via DLG2-YAP1 signaling pathway.
Differential effects of WRAP53 transcript variants on non-small cell lung cancer cell behaviors.
Exploring the molecular mechanism of Gan Shuang granules for the treatment of non-alcoholic steatohepatitis using network pharmacology, molecular docking, and experimental verification.
Normothermic ex vivo heart perfusion with NLRP3 inflammasome inhibitor Mcc950 treatment improves cardiac function of circulatory death hearts after transplantation.
Protective effect of Platycodon grandiflorus polysaccharide on apoptosis and mitochondrial damage induced by pseudorabies virus in PK-15 cells.
CHAF1A promotes the proliferation and growth of epithelial ovarian cancer cells by affecting the phosphorylation of JAK2/STAT3 signaling pathway.
Down-regulation of Hrd1 protects against myocardial ischemia-reperfusion injury by regulating PPARα to prevent oxidative stress, endoplasmic reticulum stress, and cellular apoptosis.
Regorafenib activates oxidative stress by inhibiting SELENOS and potentiates oxaliplatin-induced cell death in colon cancer cells.
A novel antimycin analogue antimycin A2c, derived from marine Streptomyces sp., suppresses HeLa cells via disrupting mitochondrial function and depleting HPV oncoproteins E6/E7.
Pseudolaric acid B induces apoptosis associated with the mitochondrial and PI3K/AKT/mTOR pathways in triple‑negative breast cancer.
Human umbilical cord-derived mesenchymal stem cells alleviate oxidative stress-induced islet impairment via the Nrf2/HO-1 axis.
FASN promotes gallbladder cancer progression and reduces cancer cell sensitivity to gemcitabine through PI3K/AKT signaling.
Dulaglutide Improves Gliosis and Suppresses Apoptosis/Autophagy Through the PI3K/Akt/mTOR Signaling Pathway in Vascular Dementia Rats.
Regorafenib induces NOX5-mediated endoplasmic reticulum stress and potentiates the anti-tumor activity of cisplatin in non-small cell lung cancer cells.
Virulence assessment of four Glaesserella parasuis strains isolated in Liaoning province of China.
Design, Synthesis and Antitumor Activity of 1H-indazole-3-amine Derivatives.
Lactiplantibacillus plantarum attenuates Coxsackievirus B3-induced pancreatitis through the BAX/BCL2/CASP3 signaling pathway.
MicroRNA-27a-3p targeting Vangl1 and Vangl2 inhibits cell proliferation in mouse granulosa cells.
GIPC2 is a tumor suppressor gene for acute myeloid leukemia and induces apoptosis of leukemia cells by regulating the PI3K/AKT pathway.
PKM2/PDK1 dual-targeted shikonin derivatives restore the sensitivity of EGFR-mutated NSCLC cells to gefitinib by remodeling glucose metabolism.
Cinepazide maleate promotes recovery from spinal cord injury by inhibiting inflammation and prolonging neuronal survival.
Knockdown of kinesin family member 4A inhibits cell proliferation, migration, and invasion while promoting apoptosis of urothelial bladder carcinoma cells.
Morusinol extracted from Morus alba induces cell cycle arrest and apoptosis via inhibition of DNA damage response in melanoma by CHK1 degradation through the ubiquitin-proteasome pathway.
Proteasomal inhibitors induce myeloma cell pyroptosis via the BAX/GSDME pathway.
Integration of proteomics and network toxicology reveals the mechanism of mercury chloride induced hepatotoxicity, in mice and HepG2 cells.
CRIP1 supports the growth and migration of AML-M5 subtype cells by activating Wnt/β-catenin pathway.
Hypothermic oxygenated perfusion attenuates DCD liver ischemia-reperfusion injury by activating the JAK2/STAT3/HAX1 pathway to regulate endoplasmic reticulum stress.
TOMM34 promotes cell proliferation, migration, and invasion of OSCC and modulates mitochondrial function.
Fra-1 induces apoptosis and neuroinflammation by targeting S100A8 to modulate TLR4 pathways in spinal cord ischemia/reperfusion injury.
DON entry into the nucleus induces DNA damage, apoptosis and cycle arrest in GES-1 cells.
Alantolactone induces concurrent apoptosis and GSDME-dependent pyroptosis of anaplastic thyroid cancer through ROS mitochondria-dependent caspase pathway.
Zhenwu decoction ameliorates cardiac hypertrophy through activating sGC (soluble guanylate cyclase) - cGMP (cyclic guanosine monophosphate) - PKG (protein kinase G) pathway.
Huntingtin-associated protein 1 is a potential tumor suppressor for gastric cancer.
Navitoclax (ABT-263) Rejuvenates Human Skin by Eliminating Senescent Dermal Fibroblasts in a Mouse/Human Chimeric Model.
Mitochondrial targeting half-sandwich iridium(III) and ruthenium(II) dppf complexes and in vitro anticancer assay.
Luteoloside Induces G0/G1 Phase Arrest of Neuroblastoma Cells by Targeting p38 MAPK.
MitomiR-504 alleviates the copper-induced mitochondria-mediated apoptosis by suppressing Bak1 expression in porcine jejunal epithelial cells.
Quercetin alleviates cadmium-induced BRL-3A cell apoptosis by inhibiting oxidative stress and the PERK/IRE1α/ATF6 signaling pathway.
Periplocin suppresses the growth of colorectal cancer cells by triggering LGALS3 (galectin 3)-mediated lysophagy.
Sanghuangporus vaninii ethanol extract alleviates hyperuricemic renal injury by regulating the uric acid transporters and inhibiting HK-2 apoptosis.
Glutamine and amino acid metabolism as a prognostic signature and therapeutic target in endometrial cancer.
Inhibition of hyaluronic acid degradation pathway suppresses glioma progression by inducing apoptosis and cell cycle arrest.
Integrated Bioinformatic Analysis Reveals TXNRD1 as a Novel Biomarker and Potential Therapeutic Target in Idiopathic Pulmonary Arterial Hypertension.
The Selenium Yeast vs Selenium Methionine on Cell Viability, Selenoprotein Profile and Redox Status via JNK/ P38 Pathway in Porcine Mammary Epithelial Cells.
SS31 Ameliorates Oxidative Stress via the Restoration of Autophagic Flux to Protect Aged Mice From Hind Limb Ischemia.
Calvatia Lilacina Extracts Exert Anti-Breast-Cancer Bioactivity through the Apoptosis Induction Dependent on Mitochondrial Reactive Oxygen Species and Caspase Activation.
Network Pharmacology-Based Prediction and Verification of the Potential Targets of Pinoresinol Diglucoside for OA Treatment.
Normothermic Ex Vivo Heart Perfusion with Mesenchymal Stem Cell-Derived Conditioned Medium Improves Myocardial Tissue Protection in Rat Donation after Circulatory Death Hearts.
Cryptotanshinone Protects against PCOS-Induced Damage of Ovarian Tissue via Regulating Oxidative Stress, Mitochondrial Membrane Potential, Inflammation, and Apoptosis via Regulating Ferroptosis.
Wenhua Juanbi Recipe Attenuates Rheumatoid Arthritis via Inhibiting miRNA-146a-Mediated Autophagy.
Pseudoephedrine Nanoparticles Alleviate Adriamycin-Induced Reproductive Toxicity Through the GnRhR Signaling Pathway.
Effects of regenerative peripheral nerve interface on dorsal root ganglia neurons following peripheral axotomy.
Exploration of the Effect and Potential Mechanism of Echinacoside Against Endometrial Cancer Based on Network Pharmacology and in vitro Experimental Verification.
Sinomenine Confers Protection Against Myocardial Ischemia Reperfusion Injury by Preventing Oxidative Stress, Cellular Apoptosis, and Inflammation.
SIRT1 Is Involved in the Neuroprotection of Pterostilbene Against Amyloid β 25-35-Induced Cognitive Deficits in Mice.
Aloe-Emodin Induces Mitochondrial Dysfunction and Pyroptosis by Activation of the Caspase-9/3/Gasdermin E Axis in HeLa Cells.
Pharmacological inhibition of SMYD2 protects against cisplatin-induced acute kidney injury in mice.
Cold Exposure Induces Intestinal Barrier Damage and Endoplasmic Reticulum Stress in the Colon via the SIRT1/Nrf2 Signaling Pathway.
Integrated network pharmacology and serum metabolomics approach deciphers the anti-colon cancer mechanisms of Huangqi Guizhi Wuwu Decoction.
Depletion of PARP10 inhibits the growth and metastatic potential of oral squamous cell carcinoma.
Porcine cGAS-STING signaling induced autophagy inhibits STING downstream IFN and apoptosis.
Sleeve gastrectomy attenuated diabetes-related cognitive decline in diabetic rats.
BI 2536 induces gasdermin E-dependent pyroptosis in ovarian cancer.
Synergistic effects of nab-PTX and anti-PD-1 antibody combination against lung cancer by regulating the Pi3K/AKT pathway through the Serpinc1 gene.
Clinical Impact of the Histopathological Index and Neuroimaging Features Status in Primary Central Nervous System Diffuse Large B-Cell Lymphoma: A Single-Center Retrospective Analysis of 51 Cases.
Ring finger protein 128 promotes, rather than inhibits, colorectal cancer progression by regulating the Hippo signaling pathway.
Calycosin suppresses colorectal cancer progression by targeting ERβ, upregulating PTEN, and inhibiting PI3K/Akt signal pathway.
Trehalose improves palmitic acid-induced apoptosis of osteoblasts by regulating SIRT3-medicated autophagy via the AMPK/mTOR/ULK1 pathway.
TFAP2C Knockdown Sensitizes Bladder Cancer Cells to Cisplatin Treatment via Regulation of EGFR and NF-κB.
Nitidine chloride induces caspase 3/GSDME-dependent pyroptosis by inhibting PI3K/Akt pathway in lung cancer.
TCHis mitigate oxidative stress and improve abnormal behavior in a prenatal valproic acid-exposed rat model of autism.
Injectable and reactive oxygen species-scavenging gelatin hydrogel promotes neural repair in experimental traumatic brain injury.
Circulating small extracellular vesicle-encapsulated SEMA5A-IT1 attenuates myocardial ischemia-reperfusion injury after cardiac surgery with cardiopulmonary bypass.
Effect of muscone on anti-apoptotic ability of muskrat prostate primary cells.
Promotion of tumor progression induced by continuous low-dose administration of antineoplastic agent gemcitabine or gemcitabine combined with cisplatin.
CCT4 knockdown enhances the sensitivity of cisplatin by inhibiting glycolysis in human esophageal squamous cell carcinomas.
RNA binding motif protein 3 (RBM3) promotes protein kinase B (AKT) activation to enhance glucose metabolism and reduce apoptosis in skeletal muscle of mice under acute cold exposure.
A novel inhibitor of ARfl and ARv7 induces protein degradation to overcome enzalutamide resistance in advanced prostate cancer.
Capsaicin suppresses hepatocarcinogenesis by inhibiting the stemness of hepatic progenitor cells via SIRT1/SOX2 signaling pathway.
Integrated metabolomics, network pharmacology and biological verification to reveal the mechanisms of Nauclea officinalis treatment of LPS-induced acute lung injury.
6-Shogaol Exhibits a Promoting Effect with Tax via Binding HSP60 in Non-Small-Cell Lung Cancer.
Blocking PARP activity with the inhibitor veliparib enhances radiotherapy sensitivity in endometrial carcinoma.
Protective Effect of Resveratrol on Immortalized Duck Intestinal Epithelial Cells Exposed to H(2)O(2).
Hernandezine Regulates Proliferation and Autophagy-Induced Apoptosis in Melanoma Cells.
Discovery of 4-Hydroxyquinazoline Derivatives as Small Molecular BET/PARP1 Inhibitors That Induce Defective Homologous Recombination and Lead to Synthetic Lethality for Triple-Negative Breast Cancer Therapy.
Inhibition of Ras protein activator like 2 produces antitumor effects in gastric cancer via the suppression of YAP1 activation.
Mechanism of a new photosensitizer (TBZPy) in the treatment of high-risk human papillomavirus-related diseases.
Effects of Ganfule capsule on microbial and metabolic profiles in anti-hepatocellular carcinoma.
Clinical significance of mitogen-activated protein kinase kinase kinases in hepatitis B virus -related hepatocellular carcinoma and underlying mechanism exploration.
Upregulation of BRD7 protects podocytes against high glucose-induced apoptosis by enhancing Nrf2 in a GSK-3β-dependent manner.
β-Elemene induces apoptosis by activating the P53 pathway in human hypertrophic scar fibroblasts.
LncDACH1 promotes mitochondrial oxidative stress of cardiomyocytes by interacting with sirtuin3 and aggravates diabetic cardiomyopathy.
High Expression of C8orf76 Is an Independent Predictive Factor of Poor Prognosis in Patients with Breast Cancer.
Protection of pancreatic β-cell by phosphocreatine through mitochondrial improvement via the regulation of dual AKT/IRS-1/GSK-3β and STAT3/Cyp-D signaling pathways.
Activation of CXCL13/CXCR5 axis aggravates experimental autoimmune cystitis and interstitial cystitis/bladder pain syndrome.
Qi-Tai-Suan, an oleanolic acid derivative, ameliorates ischemic heart failure via suppression of cardiac apoptosis, inflammation and fibrosis.
Ephedra herb reduces adriamycin-induced testicular toxicity by upregulating the gonadotropin-releasing hormone signalling pathway.
The role of ER stress and ATP/AMPK in oxidative stress meditated hepatotoxicity induced by citrinin.
Patient-derived microphysiological model identifies the therapeutic potential of metformin for thoracic aortic aneurysm.
Bunyavirus SFTSV exploits autophagic flux for viral assembly and egress.
Perilipin 5 protects against oxygen-glucose deprivation/reoxygenation-elicited neuronal damage by inhibiting oxidative stress and inflammatory injury via the Akt-GSK-3β-Nrf2 pathway.
Cancer cells corrupt normal epithelial cells through miR-let-7c-rich small extracellular vesicle-mediated downregulation of p53/PTEN.
Alnustone inhibits the growth of hepatocellular carcinoma via ROS- mediated PI3K/Akt/mTOR/p70S6K axis.
Radiocontrast agent and intraductal pressure promote the progression of post-ERCP pancreatitis by regulating inflammatory response, cellular apoptosis, and tight junction integrity.
Extracorporeal shockwave relieves endothelial injury and dysfunction in steroid-induced osteonecrosis of the femoral head via miR-135b targeting FOXO1: in vitro and in vivo studies.
Hyaluronic Acid-Modified Nanoparticles Self-Assembled from Linoleic Acid-Conjugated Chitosan for the Codelivery of miR34a and Doxorubicin in Resistant Breast Cancer.
STAT3 exerts pro-tumor and anti-autophagy roles in cervical cancer.
Porcine TRIM21 Enhances Porcine Circovirus 2 Infection and Host Immune Responses, But Inhibits Apoptosis of PCV2-Infected Cells.
Muyin extract inhibits non-small-cell lung cancer growth by inducing autophagy and apoptosis in vitro and in vivo.
Attenuation of hepatic ischemia‑reperfusion injury by adipose stem cell‑derived exosome treatment via ERK1/2 and GSK‑3β signaling pathways.
Hydroxysafflor yellow A attenuates oxidative stress injury-induced apoptosis in the nucleus pulposus cell line and regulates extracellular matrix balance via CA XII.
Cardiotoxicity of patulin was found in H9c2 cells.
RETRACTED: TRIM21 deficiency confers protection from OGD/R-induced oxidative and inflammatory damage in cultured hippocampal neurons through regulation of the Keap1/Nrf2 pathway.
Danggui Niantong granules ameliorate rheumatoid arthritis by regulating intestinal flora and promoting mitochondrial apoptosis.
PRRX1 promotes colorectal cancer stemness and chemoresistance via the JAK2/STAT3 axis by targeting IL-6.
Hsa_circ_0005050 interacts with ILF3 and affects cell apoptosis and proliferation by disrupting the balance between p53 and p65.
Novel shikonin derivatives suppress cell proliferation, migration and induce apoptosis in human triple-negative breast cancer cells via regulating PDK1/PDHC axis.
Fucoidan ameliorates LPS-induced neuronal cell damage and cognitive impairment in mice.
IL-18BP Improves Early Graft Function and Survival in Lewis-Brown Norway Rat Orthotopic Liver Transplantation Model.
Mecheliolide elicits ROS-mediated ERS driven immunogenic cell death in hepatocellular carcinoma.
Higher efficacy of resveratrol against advanced breast cancer organoids: A comparison with that of clinically relevant drugs.
Osteocytic cells exposed to titanium particles increase sclerostin expression and inhibit osteoblastic cell differentiation mostly via direct cell-to-cell contact.
Role of endoplasmic reticulum stress in cadmium-induced hepatocyte apoptosis and the protective effect of quercetin.
Dapagliflozin Improves Cardiac Function, Remodeling, Myocardial Apoptosis, and Inflammatory Cytokines in Mice with Myocardial Infarction.
The surface morphology of Platycodon grandiflorus polysaccharide and its anti-apoptotic effect by targeting autophagy.
Mesenchymal stem cells-derived exosomes prevent sepsis-induced myocardial injury by a CircRTN4/miR-497-5p/MG53 pathway.
Netrin-1 induces the anti-apoptotic and pro-survival effects of B-ALL cells through the Unc5b-MAPK axis.
Dihydroartemisinin enhances the anti-tumor activity of oxaliplatin in colorectal cancer cells by altering PRDX2-reactive oxygen species-mediated multiple signaling pathways.
CCAAT/Enhancer-Binding Protein Homologous Protein (CHOP) Deficiency Attenuates Heatstroke-Induced Intestinal Injury.
Oxycodone protects cardiac microvascular endothelial cells against ischemia/reperfusion injury by binding to Sigma-1 Receptor.
A novel promoter-associated non-coding small RNA paGLI1 recruits FUS/P65 to transactivate GLI1 gene expression and promotes infiltrating glioma progression.
CDK5RAP3 acts as a putative tumor inhibitor in papillary thyroid carcinoma via modulation of Akt/GSK-3β/Wnt/β-catenin signaling.
Cold-Induced RNA-Binding Protein Promotes Glucose Metabolism and Reduces Apoptosis by Increasing AKT Phosphorylation in Mouse Skeletal Muscle Under Acute Cold Exposure.
Cannabisin D from Sinomenium Acutum Inhibits Proliferation and Migration of Glioblastoma Cells through MAPKs Signaling.
Expression of Ubiquitin-specific protease 7 in oral squamous cell carcinoma promotes tumor cell proliferation and invasion.
Farrerol Enhances Nrf2-Mediated Defense Mechanisms against Hydrogen Peroxide-Induced Oxidative Damage in Human Retinal Pigment Epithelial Cells by Activating Akt and MAPK.
Melatonin Alleviates Contrast-Induced Acute Kidney Injury by Activation of Sirt3.
Tunicamycin-Induced Endoplasmic Reticulum Stress Promotes Breast Cancer Cell MDA-MB-231 Apoptosis through Inhibiting Wnt/β-Catenin Signaling Pathway.
Bioactive Peptide F2d Isolated from Rice Residue Exerts Antioxidant Effects via Nrf2 Signaling Pathway.
Therapeutic Efficacy of Carbon Ion Irradiation Enhanced by 11-MUA-Capped Gold Nanoparticles: An in vitro and in vivo Study.
TFEB promotes BCL-2 expression by upregulating its promoter activity in the t(6;11) translocation renal cell carcinomas.
Elevated HNF1A expression promotes radiation-resistance via driving PI3K/AKT signaling pathway in esophageal squamous cell carcinoma cells.
MicroRNA-455-5p Contributes to Cholangiocarcinoma Growth and Mediates Galangin's Anti-Tumor Effects.
Inhibition of SPATS2 Suppresses Proliferation and Invasion of Hepatocellular Carcinoma Cells through TRIM44-STAT3 Signaling Pathway.
Sonodynamic Effects of a Novel Ether-Group Modified Porphyrin Derivative Combined With Pulsed Low-Intensity Ultrasound on PC-9 Cells.
Characterization of Kinesin Family Member 2C as a Proto-Oncogene in Cervical Cancer.
miR-25 Regulates Gastric Cancer Cell Growth and Apoptosis by Targeting EGR2.
Elevated Serum FGG Levels Prognosticate and Promote the Disease Progression in Prostate Cancer.
Downregulation of miR-135b-5p Suppresses Progression of Esophageal Cancer and Contributes to the Effect of Cisplatin.
Endoplasmic reticulum stress is involved in retinal injury induced by repeated transient spikes of intraocular pressure.
Sodium alginate/collagen/stromal cell-derived factor-1 neural scaffold loaded with BMSCs promotes neurological function recovery after traumatic brain injury.
Interleukin-38 Suppresses Cell Migration and Proliferation and Promotes Apoptosis of Colorectal Cancer Cell Through Negatively Regulating Extracellular Signal-Regulated Kinases Signaling.
TSPAN1 promotes autophagy flux and mediates cooperation between WNT-CTNNB1 signaling and autophagy via the MIR454-FAM83A-TSPAN1 axis in pancreatic cancer.
Inhibition of autophagy with Chloroquine enhanced apoptosis induced by 5-aminolevulinic acid-photodynamic therapy in secondary hyperparathyroidism primary cells and organoids.
Inhibition of JAK2/STAT3 signaling pathway by panaxadiol limits the progression of pancreatic cancer.
Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.
Switch receptor T3/28 improves long-term persistence and antitumor efficacy of CAR-T cells.
m(6)A-mediated upregulation of AC008 promotes osteoarthritis progression through the miR-328-3p‒AQP1/ANKH axis.
The inhibitory effect Polygonum Cillinerve polysaccharide on transmissible gastroenteritis virus of swine.
Protocatechuic aldehyde protects cardiomycoytes against ischemic injury via regulation of nuclear pyruvate kinase M2.
Morphine promotes the malignant biological behavior of non-small cell lung cancer cells through the MOR/Src/mTOR pathway.
Grape Seed Proanthocyanidin Ameliorates FB(1)-Induced Meiotic Defects in Porcine Oocytes.
ACE Inhibitory Peptide from Skin Collagen Hydrolysate of Takifugu bimaculatus as Potential for Protecting HUVECs Injury.
Ampelopsin Inhibits Breast Cancer Cell Growth through Mitochondrial Apoptosis Pathway.
Sodium cantharidate induces Apoptosis in breast cancer cells by regulating energy metabolism via the protein phosphatase 5-p53 axis.
Methylation gene KCNC1 is associated with overall survival in patients with seminoma.
IL‑33/ST2 promotes the malignant progression of gastric cancer via the MAPK pathway.
20(S)-ginsenoside Rh2 induces caspase-dependent promyelocytic leukemia-retinoic acid receptor A degradation in NB4 cells via Akt/Bax/caspase9 and TNF-α/caspase8 signaling cascades.
Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway.
FAM122A promotes acute myeloid leukemia cell growth through inhibiting PP2A activity and sustaining MYC expression.
Iguratimod-encapsulating PLGA-NPs induce human multiple myeloma cell death via reactive oxygen species and Caspase-dependent signalling.
Sparstolonin B exerts beneficial effects on prostate cancer by acting on the reactive oxygen species-mediated PI3K/AKT pathway.
Fructose-1,6-bisphosphatase aggravates oxidative stress-induced apoptosis in asthma by suppressing the Nrf2 pathway.
Oxymatrine pretreatment protects H9c2 cardiomyocytes from hypoxia/reoxygenation injury by modulating the PI3K/Akt pathway.
Design, synthesis and biological evaluation of anilide (dicarboxylic acid) shikonin esters as antitumor agents through targeting PI3K/Akt/mTOR signaling pathway.
O-GlcNAc / Akt pathway regulates glucose metabolism and reduces apoptosis in liver of piglets with acute cold stress.
A natural product, Piperlongumine (PL), increases tumor cells sensitivity to NK cell killing.
YAP/TEAD4-induced KIF4A contributes to the progression and worse prognosis of esophageal squamous cell carcinoma.
HORMAD1 promotes docetaxel resistance in triple negative breast cancer by enhancing DNA damage tolerance.
Dynamin 3 overexpression suppresses the proliferation, migration and invasion of cervical cancer cells.
BACH1 is transcriptionally inhibited by TET1 in hepatocellular carcinoma in a microRNA-34a-dependent manner to regulate autophagy and inflammation.
HDAC6 suppresses microRNA-199a transcription and augments HPV-positive cervical cancer progression through Wnt5a upregulation.
Comparable radiation sensitivity in p53 wild-type and p53 deficient tumor cells associated with different cell death modalities.
Effects and mechanism of microRNA‑218 against lung cancer.
Antitumor effects of dioscin in A431 cells via adjusting ATM/p53-mediated cell apoptosis, DNA damage and migration.
Histone deacetylase 10 exerts anti-tumor effects on cervical cancer via a novel microRNA-223/TXNIP/Wnt/β-catenin pathway.
BAIAP2L2 promotes the proliferation, migration and invasion of osteosarcoma associated with the Wnt/β-catenin pathway.
MET inhibition enhances PARP inhibitor efficacy in castration-resistant prostate cancer by suppressing the ATM/ATR and PI3K/AKT pathways.
Ketoprofen and Loxoprofen Platinum(IV) Complexes Displaying Antimetastatic Activities by Inducing DNA Damage, Inflammation Suppression, and Enhanced Immune Response.
Protective Effect of Flavonoids from a Deep-Sea-Derived Arthrinium sp. against ox-LDL-Induced Oxidative Injury through Activating the AKT/Nrf2/HO-1 Pathway in Vascular Endothelial Cells.
Structural analysis of Panax ginseng glycoproteins and its anti-oligoasthenozoospermia effect in vivo.
Acetylcholine ameliorated hypoxia-induced oxidative stress and apoptosis in trophoblast cells via p38 MAPK/NF-κB pathway.
circBTBD7 Promotes Immature Porcine Sertoli Cell Growth through Modulating miR-24-3p/MAPK7 Axis to Inactivate p38 MAPK Signaling Pathway.
Limonin induces apoptosis of HL-60 cells by inhibiting NQO1 activity.
Histone deacetylase 10 exerts antitumor effects on cervical cancer via a novel microRNA-223/TXNIP/Wnt/β-catenin pathway.
Heat shock protein 22 modulates NRF1/TFAM-dependent mitochondrial biogenesis and DRP1-sparked mitochondrial apoptosis through AMPK-PGC1α signaling pathway to alleviate the early brain injury of subarachnoid hemorrhage in rats.
Glaucocalyxin A induces cell cycle arrest and apoptosis via inhibiting NF-κB/p65 signaling pathway in melanoma cells.
Anticancer Activity of Tetrandrine by Inducing Apoptosis in Human Breast Cancer Cell Line MDA-MB-231 In Vivo.
Galangin Inhibits Cholangiocarcinoma Cell Growth and Metastasis through Downregulation of MicroRNA-21 Expression.
Homoharringtonine Exerts an Antimyeloma Effect by Promoting Excess Parkin-Dependent Mitophagy.
Antitumor effects of aconitine in A2780 cells via estrogen receptor β‑mediated apoptosis, DNA damage and migration.
Anti‑proliferative effect of honokiol on SW620 cells through upregulating BMP7 expression via the TGF‑β1/p53 signaling pathway.
Synthesis and biological evaluations of N'-substituted methylene-4-(quinoline-4-amino) benzoylhydrazides as potential anti-hepatoma agents.
Cyclovirobuxine D Exerts Anticancer Effects by Suppressing the EGFR-FAK-AKT/ERK1/2-Slug Signaling Pathway in Human Hepatocellular Carcinoma.
Insights into mechanisms of pranoprofen-induced apoptosis and necroptosis in human corneal stromal cells.
Long noncoding RNA linc00467 plays an oncogenic role in hepatocellular carcinoma by regulating the miR-18a-5p/NEDD9 axis.
The roles of SHANK1 in the development of colon cancer.
Thermosensitive heparin-poloxamer hydrogel encapsulated bFGF and NGF to treat spinal cord injury.
Protective Effects of Ischemic Postconditioning on Livers in Rats with Limb Ischemia-Reperfusion via Glycogen Synthase Kinase 3 beta (GSK-3β)/Fyn/Nuclear Receptor-Erythroid-2-Related Factor (Nrf2) Pathway.
Intracellular expression of arginine deiminase activates the mitochondrial apoptosis pathway by inhibiting cytosolic ferritin and inducing chromatin autophagy.
Cinnamaldehyde Enhances Antimelanoma Activity through Covalently Binding ENO1 and Exhibits a Promoting Effect with Dacarbazine.
Oxaliplatin resistance is enhanced by saracatinib via upregulation Wnt-ABCG1 signaling in hepatocellular carcinoma.
Human cathelicidin antimicrobial peptide suppresses proliferation, migration and invasion of oral carcinoma HSC-3 cells via a novel mechanism involving caspase-3 mediated apoptosis.
Long noncoding RNA HAND2-AS1 reduced the viability of hepatocellular carcinoma via targeting microRNA-300/SOCS5 axis.
Down-regulation of long noncoding RNA LINC00472 alleviates sepsis-induced acute hepatic injury by regulating miR-373-3p/TRIM8 axis.
Acetylcholine ameliorated TNF-α-induced primary trophoblast malfunction via muscarinic receptors†.
METTL3 serves an oncogenic role in human ovarian cancer cells partially via the AKT signaling pathway.
Physicochemical characterization of polysaccharide from the leaf of Dendrobium officinale and effect on LPS induced damage in GES-1 cell.
High glucose causes apoptosis of rabbit corneal epithelial cells involving activation of PERK-eIF2α-CHOP-caspase-12 signaling pathway.
Emodin Induced SREBP1-Dependent and SREBP1-Independent Apoptosis in Hepatocellular Carcinoma Cells.
Simvastatin promotes endothelial dysfunction by activating the Wnt/β‑catenin pathway under oxidative stress.
Linc01105 acts as an oncogene in the development of neuroblastoma.
Anti-Inflammatory and Anti-Apoptotic Effects of Stybenpropol A on Human Umbilical Vein Endothelial Cells.
Knockdown of long noncoding RNA DLEU1 suppresses the progression of renal cell carcinoma by downregulating the Akt pathway.
Regulating glycolysis, the TLR4 signal pathway and expression of RBM3 in mouse liver in response to acute cold exposure.
Effects of Cold-inducible RNA-binding Protein (CIRP) on Liver Glycolysis during Acute Cold Exposure in C57BL/6 Mice.
Sphingomyelin Synthase 2 Promotes Endothelial Dysfunction by Inducing Endoplasmic Reticulum Stress.
Rho GDP dissociation inhibitor α silencing attenuates silicosis by inhibiting RhoA/Rho kinase signalling.
The interaction of Atg4B and Bcl-2 plays an important role in Cd-induced crosstalk between apoptosis and autophagy through disassociation of Bcl-2-Beclin1 in A549 cells.
Derlin1 functions as an oncogene in cervical cancer via AKT/mTOR signaling pathway.
Silencing TTK expression inhibits the proliferation and progression of prostate cancer.
Protective effects of Platycodon grandiflorus polysaccharides against apoptosis induced by carbonyl cyanide 3-chlorophenylhydrazone in 3D4/21 cells.
MicroRNA-2053 overexpression inhibits the development and progression of hepatocellular carcinoma.
CDKL1 promotes the chemoresistance of human oral squamous cell carcinoma cells to hydroxycamptothecin.
Alkaline ceramidase 3 promotes growth of hepatocellular carcinoma cells via regulating S1P/S1PR2/PI3K/AKT signaling.
UNBS5162 inhibits proliferation of human melanoma cells by inducing apoptosis via the PI3K/Akt pathway.
Effects of Acute Cold Stress on Liver O-GlcNAcylation and Glycometabolism in Mice.
14-3-3ε is a nuclear matrix protein, and its altered expression and localization are associated with curcumin-induced apoptosis of MG-63 cells.
A small molecule targeting glutathione activates Nrf2 and inhibits cancer cell growth through promoting Keap-1 S-glutathionylation and inducing apoptosis.
Urea transport B gene induces melanoma B16 cell death via activation of p53 and mitochondrial apoptosis.
Knockdown of PAICS inhibits malignant proliferation of human breast cancer cell lines.
Resveratrol attenuates mechanical compression-induced nucleus pulposus cell apoptosis through regulating the ERK1/2 signaling pathway in a disc organ culture.
Anti-tumor effect of evodiamine by inducing Akt-mediated apoptosis in hepatocellular carcinoma.
Resveratrol sequentially induces replication and oxidative stresses to drive p53-CXCR2 mediated cellular senescence in cancer cells.
The role of the ATM/Chk/P53 pathway in mediating DNA damage in hand-foot syndrome induced by PLD.
Long Non-Coding RNA BANCR Promotes Endometrial Cancer Cell Proliferation and Invasion by Regulating MMP2 and MMP1 via ERK/MAPK Signaling Pathway.
A targeted proteomics approach to the quantitative analysis of ERK/Bcl-2-mediated anti-apoptosis and multi-drug resistance in breast cancer.
Neuroprotective effect of ethyl acetate extract from gastrodia elata against transient focal cerebral ischemia in rats induced by middle cerebral artery occlusion.
Mechanisms underlying 3-bromopyruvate-induced cell death in colon cancer.
Melatonin synergized with cyclosporine A improves cardiac allograft survival by suppressing inflammation and apoptosis.
Apoptosis-induced anti-tumor effect of Curcuma kwangsiensis polysaccharides against human nasopharyngeal carcinoma cells.
Yu H, Wang J, Liu M, Hu C, Sun J, Xu B, Lu S, Huang D, Pang Q, Hu C
Experimental lung research 2024;50(1):15-24
Experimental lung research 2024;50(1):15-24
Knockdown of programmed cell death factor 4 restores erectile function by attenuating apoptosis in rats with bilateral cavernous nerve crush injury.
Ge Y, Xia T, Feng Z, Xi Y, Hu D, Hong Y, Tang B, Wu J, Chen J, Xiao H
Andrology 2024 Sep;12(6):1439-1448
Andrology 2024 Sep;12(6):1439-1448
Promotion of apoptosis in melanoma cells by taxifolin through the PI3K/AKT signaling pathway: Screening of natural products using WGCNA and CMAP platforms.
Wang Y, Chen SJ, Ma T, Long Q, Chen L, Xu KX, Cao Y
International immunopharmacology 2024 Sep 10;138:112517
International immunopharmacology 2024 Sep 10;138:112517
Untargeted serum and gastric metabolomics and network pharmacology analysis reveal the superior efficacy of zingiberis rhizoma recens-/euodiae fructus-processed Coptidis Rhizoma on gastric ulcer rats.
Zhang Z, Zheng Y, Zhang B, Wang R, Chen L, Wang Y, Feng W, Zheng X, Li K, Zhou N
Journal of ethnopharmacology 2024 Oct 5;332:118376
Journal of ethnopharmacology 2024 Oct 5;332:118376
Carnosol alleviates sepsis-induced pulmonary endothelial barrier dysfunction by targeting nuclear factor erythroid2-related factor 2/sirtuin-3 signaling pathway to attenuate oxidative damage.
Li X, Wang S, Luo M, Wang M, Wu S, Liu C, Wang F, Li Y
Phytotherapy research : PTR 2024 May;38(5):2182-2197
Phytotherapy research : PTR 2024 May;38(5):2182-2197
Human umbilical cord mesenchymal stem cell-derived exosomal miR-214-3p regulates the progression of gallbladder cancer by regulating ACLY/GLUT1.
Liu L, Xiao W, Yang Z, Wang Q, Yi J
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2024 May;33(5):499-510
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2024 May;33(5):499-510
Identification of immunogenic cell death-related damage-related molecular patterns (DAMPs) to predict outcomes in patients with head and neck squamous cell carcinoma.
Zhang J, Shi X, Wang M, Zhai R, Wang M, Gong Z, Ni Z, Xu T, Zhu W, Liu L
Journal of cancer research and clinical oncology 2024 May 7;150(5):240
Journal of cancer research and clinical oncology 2024 May 7;150(5):240
Neuroprotective effects of apigenin on retinal ganglion cells in ischemia/reperfusion: modulating mitochondrial dynamics in in vivo and in vitro models.
Wu J, Zhang D, Liu H, Li J, Li T, Wu J, Zhang S
Journal of translational medicine 2024 May 13;22(1):447
Journal of translational medicine 2024 May 13;22(1):447
PPP2R2A inhibition contributes to preeclampsia by regulating the proliferation, apoptosis, and angiogenesis modulation potential of mesenchymal stem cells.
Liu Y, Gu F, Gao J, Gu Y, Li Z, Lu D, Zhang Y
Cell division 2024 May 11;19(1):18
Cell division 2024 May 11;19(1):18
VHL suppresses autophagy and tumor growth through PHD1-dependent Beclin1 hydroxylation.
Wang Z, Yan M, Ye L, Zhou Q, Duan Y, Jiang H, Wang L, Ouyang Y, Zhang H, Shen Y, Ji G, Chen X, Tian Q, Xiao L, Wu Q, Meng Y, Liu G, Ma L, Lei B, Lu Z, Xu D
The EMBO journal 2024 Mar;43(6):931-955
The EMBO journal 2024 Mar;43(6):931-955
High expression of B7-H3 on monocyte/macrophages in tumor microenvironment promotes lung cancer progression by inhibiting apoptosis.
Zhang D, Huang H, Gao X, Yu G, Zhang X, Jin H, Xu R, Wang Z, Zhang G
Translational oncology 2024 Mar;41:101874
Translational oncology 2024 Mar;41:101874
A decrease in integrin α5β1/FAK is associated with increased apoptosis of aortic smooth muscle cells in acute type a aortic dissection.
Xue M, Xing L, Yang Y, Shao M, Liao F, Xu F, Chen Y, Wang S, Chen B, Yao C, Gu G, Tong C
BMC cardiovascular disorders 2024 Mar 26;24(1):180
BMC cardiovascular disorders 2024 Mar 26;24(1):180
Ubiquitinome Analysis Uncovers Alterations in Synaptic Proteins and Glucose Metabolism Enzymes in the Hippocampi of Adolescent Mice Following Cold Exposure.
Li XY, Yin X, Lu JJ, Li QR, Xing WQ, Han Q, Ji H, Li SZ, Yang HM, Guo JR, Wang ZQ, Xu B
Cells 2024 Mar 25;13(7)
Cells 2024 Mar 25;13(7)
Mechanisms of intermittent theta-burst stimulation attenuating nerve injury after ischemic reperfusion in rats through endoplasmic reticulum stress and ferroptosis.
Shen XY, Zhang XY, Han PP, Zhao YN, Xu GH, Bi X
Molecular biology reports 2024 Mar 1;51(1):377
Molecular biology reports 2024 Mar 1;51(1):377
Effect of black cloth ointment on hypertrophic scar formation: An investigation using integrated network pharmacology and animal assay.
Guo Q, Ji J, Chen F, Shi J, Liu H, Zhu C
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 2024 Jun;30(6):e13791
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 2024 Jun;30(6):e13791
Downregulation of SMAD4 protects HaCaT cells against UVB-induced damage and oxidative stress through the activation of EMT.
Li X, Wang Y, Wang X, Shen Y, Yuan Y, He Q, Mao S, Wu C, Zhou M
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2024 Jun;23(6):1051-1065
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2024 Jun;23(6):1051-1065
Delivery of exogenous miR-19b by Wharton's Jelly Mesenchymal Stem Cells attenuates transplanted kidney ischemia/reperfusion injury by regulating cellular metabolism.
Wu X, Wu X, Wang Z, Tian X, Zhang C, Cao G, Gu Y, Yan T
Drug delivery and translational research 2024 Jun 25;
Drug delivery and translational research 2024 Jun 25;
Chidamide enhances T-cell-mediated anti-tumor immune function by inhibiting NOTCH1/NFATC1 signaling pathway in ABC-type diffuse large B-cell lymphoma.
Li L, Yang W, Pan Y, Ye R, Wang Y, Li S, Jiang H, Zhang Q, Wang X, Yan J
Leukemia & lymphoma 2024 Jul;65(7):895-910
Leukemia & lymphoma 2024 Jul;65(7):895-910
Calcitonin gene‑related peptide alleviates hyperoxia‑induced human alveolar cell injury via the CGRPR/TRPV1/Ca2(+) axis.
Li JH, Wan HX, Wu LH, Fang F, Wang JX, Dong H, Xu F
Molecular medicine reports 2024 Jul;30(1)
Molecular medicine reports 2024 Jul;30(1)
FUDNC1-dependent mitophagy ameliorate motor neuron death in an amyotrophic lateral sclerosis mouse model.
Guo X, Zhang Z, Gu J, Ke P, Liu J, Meng Y, Zheng W, Que W, Fan R, Luo J, Xiao F
Neurobiology of disease 2024 Jul;197:106534
Neurobiology of disease 2024 Jul;197:106534
Hematoporphyrin derivative photodynamic therapy induces apoptosis and suppresses the migration of human esophageal squamous cell carcinoma cells by regulating the PI3K/AKT/mTOR signaling pathway.
Wei X, Ni J, Yuan L, Li X
Oncology letters 2024 Jan;27(1):17
Oncology letters 2024 Jan;27(1):17
Argininyl-Fructosyl-Galactose: A Novel Amino Acid Derivative improves Cisplatin-induced Intestinal Toxicity via Reactive Oxygen Species- mediated Apoptosis Pathway.
Liu W, Zheng YN, Jiang S, Ren S, Tang S, Zhang J, Wang Z, Li W
Current medicinal chemistry 2024 Jan 8;
Current medicinal chemistry 2024 Jan 8;
METTL1 mediated tRNA m(7)G modification promotes leukaemogenesis of AML via tRNA regulated translational control.
Zhao P, Xia L, Chen D, Xu W, Guo H, Xu Y, Yan B, Wu X, Li Y, Zhang Y, Zhang X
Experimental hematology & oncology 2024 Jan 24;13(1):8
Experimental hematology & oncology 2024 Jan 24;13(1):8
Loganin protects against myocardial ischemia-reperfusion injury by modulating oxidative stress and cellular apoptosis via activation of JAK2/STAT3 signaling.
Xia B, Ding J, Li Q, Zheng K, Wu J, Huang C, Liu K, You Q, Yuan X
International journal of cardiology 2024 Jan 15;395:131426
International journal of cardiology 2024 Jan 15;395:131426
Chemoproteomics Reveals Glaucocalyxin A Induces Mitochondria-Dependent Apoptosis of Leukemia Cells via Covalently Binding to VDAC1.
An Y, Zhang Q, Chen Y, Xia F, Wong YK, He H, Hao M, Tian J, Zhang X, Luo P, Wang J
Advanced biology 2024 Feb;8(2):e2300538
Advanced biology 2024 Feb;8(2):e2300538
A study on the role of Taxifolin in inducing apoptosis of pancreatic cancer cells: screening results using weighted gene co-expression network analysis.
Chen SJ, Ren LK, Fei XB, Liu P, Wang X, Zhu CH, Pan YZ
Aging 2024 Feb 1;16(3):2617-2637
Aging 2024 Feb 1;16(3):2617-2637
The effects of anti-lung cancer in nude mice by a fully human single-chain antibody against associated antigen Ts7TMR between A549 cells and Trichinella spiralis.
Yue T, Wang J, Liu F, Gong P, Li J, Zhang X, Zhang N
Artificial cells, nanomedicine, and biotechnology 2024 Dec;52(1):300-308
Artificial cells, nanomedicine, and biotechnology 2024 Dec;52(1):300-308
The combination of Butyricicoccus pullicaecorum and 3-hydroxyanthranilic acid prevents postmenopausal osteoporosis by modulating gut microbiota and Th17/Treg.
Zhu F, Liu H, Cao Y, Dai B, Wu H, Li W
European journal of nutrition 2024 Aug;63(5):1945-1959
European journal of nutrition 2024 Aug;63(5):1945-1959
Corynoxine triggers cell death via activating PP2A and regulating AKT-mTOR/GSK3β axes in NSCLC.
Hou G, Hu W, Sang Y, Gan X, Xu H, Hu Q, Cao X
Biochemical pharmacology 2024 Apr;222:116110
Biochemical pharmacology 2024 Apr;222:116110
Treadmill training improves lung function and inhibits alveolar cell apoptosis in spinal cord injured rats.
Wang X, Fu Y, Yang X, Chen Y, Zeng N, Hu S, Ouyang S, Pan X, Wu S
Scientific reports 2024 Apr 27;14(1):9723
Scientific reports 2024 Apr 27;14(1):9723
Transcutaneous Electrical Nerve Stimulation (TENS) Alleviates Brain Ischemic Injury by Regulating Neuronal Oxidative Stress, Pyroptosis, and Mitophagy.
Tan Z, Dong F, Wu L, Feng Y, Zhang M, Zhang F
Mediators of inflammation 2023;2023:5677865
Mediators of inflammation 2023;2023:5677865
Extracellular vesicles carrying miR-6836 derived from resistant tumor cells transfer cisplatin resistance of epithelial ovarian cancer via DLG2-YAP1 signaling pathway.
Zou Y, Zhao Z, Wang J, Ma L, Liu Y, Sun L, Song Y
International journal of biological sciences 2023;19(10):3099-3114
International journal of biological sciences 2023;19(10):3099-3114
Differential effects of WRAP53 transcript variants on non-small cell lung cancer cell behaviors.
Zhu Y, Sun W, Jiang X, Bai R, Luo Y, Gao Y, Li S, Huang Z, Gong Y, Xie C
PloS one 2023;18(1):e0281132
PloS one 2023;18(1):e0281132
Exploring the molecular mechanism of Gan Shuang granules for the treatment of non-alcoholic steatohepatitis using network pharmacology, molecular docking, and experimental verification.
Zhi G, Shao B, Zheng T, Mu J, Li J, Feng Y, Zhu S, Dang Y, Liu F, Wang D
Frontiers in pharmacology 2023;14:1082451
Frontiers in pharmacology 2023;14:1082451
Normothermic ex vivo heart perfusion with NLRP3 inflammasome inhibitor Mcc950 treatment improves cardiac function of circulatory death hearts after transplantation.
Xu L, Zeng Z, Niu C, Liu D, Lin S, Liu X, Szabó G, Lu J, Zheng S, Zhou P
Frontiers in cardiovascular medicine 2023;10:1126391
Frontiers in cardiovascular medicine 2023;10:1126391
Protective effect of Platycodon grandiflorus polysaccharide on apoptosis and mitochondrial damage induced by pseudorabies virus in PK-15 cells.
Xing Y, Cui Y, Xu G, Qi C, Zhang M, Cheng G, Liu Y, Liu J
Cell biochemistry and biophysics 2023 Sep;81(3):493-502
Cell biochemistry and biophysics 2023 Sep;81(3):493-502
CHAF1A promotes the proliferation and growth of epithelial ovarian cancer cells by affecting the phosphorylation of JAK2/STAT3 signaling pathway.
Xia D, Xu X, Wei J, Wang W, Xiong J, Tan Q, Xue P, Wang H
Biochemistry and biophysics reports 2023 Sep;35:101522
Biochemistry and biophysics reports 2023 Sep;35:101522
Down-regulation of Hrd1 protects against myocardial ischemia-reperfusion injury by regulating PPARα to prevent oxidative stress, endoplasmic reticulum stress, and cellular apoptosis.
Xia B, Li Q, Zheng K, Wu J, Huang C, Liu K, You Q, Yuan X
European journal of pharmacology 2023 Sep 5;954:175864
European journal of pharmacology 2023 Sep 5;954:175864
Regorafenib activates oxidative stress by inhibiting SELENOS and potentiates oxaliplatin-induced cell death in colon cancer cells.
Yu Y, Wu T, Zhang X, Li P, Ye L, Kuang J, Tao L, Ni L, Zhao Q, Zhang J, Pan H, Xie C, Zheng C, Li S, Cui R
European journal of pharmacology 2023 Oct 15;957:175986
European journal of pharmacology 2023 Oct 15;957:175986
A novel antimycin analogue antimycin A2c, derived from marine Streptomyces sp., suppresses HeLa cells via disrupting mitochondrial function and depleting HPV oncoproteins E6/E7.
Zhang W, Che Q, Tan H, Qi X, Li D, Zhu T, Liu M
Life sciences 2023 Oct 1;330:121998
Life sciences 2023 Oct 1;330:121998
Pseudolaric acid B induces apoptosis associated with the mitochondrial and PI3K/AKT/mTOR pathways in triple‑negative breast cancer.
Yang K, Wang JQ, Li K, Chen SN, Yu F
Oncology reports 2023 Nov;50(5)
Oncology reports 2023 Nov;50(5)
Human umbilical cord-derived mesenchymal stem cells alleviate oxidative stress-induced islet impairment via the Nrf2/HO-1 axis.
Liu P, Cao B, Zhou Y, Zhang H, Wang C
Journal of molecular cell biology 2023 Nov 27;15(5)
Journal of molecular cell biology 2023 Nov 27;15(5)
FASN promotes gallbladder cancer progression and reduces cancer cell sensitivity to gemcitabine through PI3K/AKT signaling.
Cheng H, Sun Y, Yu X, Zhou D, Ding J, Wang S, Ma F
Drug discoveries & therapeutics 2023 Nov 18;17(5):328-339
Drug discoveries & therapeutics 2023 Nov 18;17(5):328-339
Dulaglutide Improves Gliosis and Suppresses Apoptosis/Autophagy Through the PI3K/Akt/mTOR Signaling Pathway in Vascular Dementia Rats.
Guan T, Xiao Y, Xie X, Meng N, Qi Q, Xu J, Jiang X, Zhang Z, Teng Z, Lv P
Neurochemical research 2023 May;48(5):1561-1579
Neurochemical research 2023 May;48(5):1561-1579
Regorafenib induces NOX5-mediated endoplasmic reticulum stress and potentiates the anti-tumor activity of cisplatin in non-small cell lung cancer cells.
Sui H, Xiao S, Jiang S, Wu S, Lin H, Cheng L, Ye L, Zhao Q, Yu Y, Tao L, Kong FM, Huang X, Cui R
Neoplasia (New York, N.Y.) 2023 May;39:100897
Neoplasia (New York, N.Y.) 2023 May;39:100897
Virulence assessment of four Glaesserella parasuis strains isolated in Liaoning province of China.
Yan P, Jia YC, Zhang XL, Zhou YY, Guo Y, Yin RL, Yuan J, Wang LX, Guo ZB, Wang JY, Wang X, Yin RH
Research in veterinary science 2023 May;158:226-234
Research in veterinary science 2023 May;158:226-234
Design, Synthesis and Antitumor Activity of 1H-indazole-3-amine Derivatives.
Wang C, Zhu M, Long X, Wang Q, Wang Z, Ouyang G
International journal of molecular sciences 2023 May 12;24(10)
International journal of molecular sciences 2023 May 12;24(10)
Lactiplantibacillus plantarum attenuates Coxsackievirus B3-induced pancreatitis through the BAX/BCL2/CASP3 signaling pathway.
Yu X, Zhang Y, Pei K, Tan J, Tian H, Xu T, Liu F, Peng N, Huang Y, Huang X, Huang X, Wu J, Liu Q, Zeng L, Hua W, Huang X
Food & function 2023 May 11;14(9):4129-4142
Food & function 2023 May 11;14(9):4129-4142
MicroRNA-27a-3p targeting Vangl1 and Vangl2 inhibits cell proliferation in mouse granulosa cells.
Tao H, Yang J, Xu M, Liu Z, Liu Y, Xiong Q
Biochimica et biophysica acta. Gene regulatory mechanisms 2023 Mar;1866(1):194885
Biochimica et biophysica acta. Gene regulatory mechanisms 2023 Mar;1866(1):194885
GIPC2 is a tumor suppressor gene for acute myeloid leukemia and induces apoptosis of leukemia cells by regulating the PI3K/AKT pathway.
Zhao J, Liu J, Liu S, Tian S, Yuan H, Li S
Epigenomics 2023 Mar;15(6):369-383
Epigenomics 2023 Mar;15(6):369-383
PKM2/PDK1 dual-targeted shikonin derivatives restore the sensitivity of EGFR-mutated NSCLC cells to gefitinib by remodeling glucose metabolism.
Lin H, Han H, Yang M, Wen Z, Chen Q, Ma Y, Wang X, Wang C, Yin T, Wang X, Lu G, Chen H, Qi J, Yang Y
European journal of medicinal chemistry 2023 Mar 5;249:115166
European journal of medicinal chemistry 2023 Mar 5;249:115166
Cinepazide maleate promotes recovery from spinal cord injury by inhibiting inflammation and prolonging neuronal survival.
Li D, Zhao S, Zhu B, Zhao W, Ding Y, Li X, Fu D, Yu H, Wang B, Pan T
Drug development research 2023 Jun;84(4):736-746
Drug development research 2023 Jun;84(4):736-746
Knockdown of kinesin family member 4A inhibits cell proliferation, migration, and invasion while promoting apoptosis of urothelial bladder carcinoma cells.
Zhang C, Wang M, Ying Y, Meng F, Gao H, Zeng S, Zhu Y, Liu A, Zhang Z, Xu C
Cancer medicine 2023 Jun;12(11):12581-12592
Cancer medicine 2023 Jun;12(11):12581-12592
Morusinol extracted from Morus alba induces cell cycle arrest and apoptosis via inhibition of DNA damage response in melanoma by CHK1 degradation through the ubiquitin-proteasome pathway.
Guo L, Dong Z, Zhang X, Yang Y, Hu X, Ji Y, Li C, Wan S, Xu J, Liu C, Zhang Y, Liu L, Shi Y, Wu Z, Liu Y, Cui H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154765
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154765
Proteasomal inhibitors induce myeloma cell pyroptosis via the BAX/GSDME pathway.
Liang JP, He YM, Cui YL, Sun YN, He GS, Zhu ZG, Mao XL
Acta pharmacologica Sinica 2023 Jul;44(7):1464-1474
Acta pharmacologica Sinica 2023 Jul;44(7):1464-1474
Integration of proteomics and network toxicology reveals the mechanism of mercury chloride induced hepatotoxicity, in mice and HepG2 cells.
Cao X, Mao K, Zhang Y, Yang M, Liu H, Wang X, Hao L
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jul;177:113820
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jul;177:113820
CRIP1 supports the growth and migration of AML-M5 subtype cells by activating Wnt/β-catenin pathway.
Deng X, Zeng Y, Qiu X, Zhong M, Xiong X, Luo M, Zhang J, Chen X
Leukemia research 2023 Jul;130:107312
Leukemia research 2023 Jul;130:107312
Hypothermic oxygenated perfusion attenuates DCD liver ischemia-reperfusion injury by activating the JAK2/STAT3/HAX1 pathway to regulate endoplasmic reticulum stress.
Yue P, Lv X, You J, Zou Y, Luo J, Lu Z, Cao H, Liu Z, Fan X, Ye Q
Cellular & molecular biology letters 2023 Jul 12;28(1):55
Cellular & molecular biology letters 2023 Jul 12;28(1):55
TOMM34 promotes cell proliferation, migration, and invasion of OSCC and modulates mitochondrial function.
Huang Y, Chen Z, Chen X, Chen X, Xu M
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2023 Jan;52(1):47-55
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2023 Jan;52(1):47-55
Fra-1 induces apoptosis and neuroinflammation by targeting S100A8 to modulate TLR4 pathways in spinal cord ischemia/reperfusion injury.
Chen Y, Dong Y, Zhang ZL, Han J, Chen FS, Tong XY, Ma H
Brain pathology (Zurich, Switzerland) 2023 Jan;33(1):e13113
Brain pathology (Zurich, Switzerland) 2023 Jan;33(1):e13113
DON entry into the nucleus induces DNA damage, apoptosis and cycle arrest in GES-1 cells.
Hou S, Cheng Y, Wang Z, Xia L, Wang J, Wang H, Sun J, Ma J, Yan Y
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jan;171:113531
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jan;171:113531
Alantolactone induces concurrent apoptosis and GSDME-dependent pyroptosis of anaplastic thyroid cancer through ROS mitochondria-dependent caspase pathway.
Hu Y, Wen Q, Cai Y, Liu Y, Ma W, Li Q, Song F, Guo Y, Zhu L, Ge J, Zeng Q, Wang J, Yin C, Zheng G, Ge M
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;108:154528
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;108:154528
Zhenwu decoction ameliorates cardiac hypertrophy through activating sGC (soluble guanylate cyclase) - cGMP (cyclic guanosine monophosphate) - PKG (protein kinase G) pathway.
Chen L, Zhou X, Deng Y, Yang Y, Chen X, Chen Q, Liu Y, Fu X, Kwan HY, You Y, Jin W, Zhao X
Journal of ethnopharmacology 2023 Jan 10;300:115705
Journal of ethnopharmacology 2023 Jan 10;300:115705
Huntingtin-associated protein 1 is a potential tumor suppressor for gastric cancer.
Qu YM, Chen A, Zhao X, Wang Z, Guo D, Shao SL, Tao YY, Li QJ, Wang MY, Ma WS
Molecular biology reports 2023 Feb;50(2):1517-1531
Molecular biology reports 2023 Feb;50(2):1517-1531
Navitoclax (ABT-263) Rejuvenates Human Skin by Eliminating Senescent Dermal Fibroblasts in a Mouse/Human Chimeric Model.
Takaya K, Ishii T, Asou T, Kishi K
Rejuvenation research 2023 Feb;26(1):9-20
Rejuvenation research 2023 Feb;26(1):9-20
Mitochondrial targeting half-sandwich iridium(III) and ruthenium(II) dppf complexes and in vitro anticancer assay.
Liu J, Wu Y, Yang G, Liu Z, Liu X
Journal of inorganic biochemistry 2023 Feb;239:112069
Journal of inorganic biochemistry 2023 Feb;239:112069
Luteoloside Induces G0/G1 Phase Arrest of Neuroblastoma Cells by Targeting p38 MAPK.
He Y, Luo M, Lei S, Zeng Z, Chen T, Wu Y, Wang D, Wang L, Wang L
Molecules (Basel, Switzerland) 2023 Feb 12;28(4)
Molecules (Basel, Switzerland) 2023 Feb 12;28(4)
MitomiR-504 alleviates the copper-induced mitochondria-mediated apoptosis by suppressing Bak1 expression in porcine jejunal epithelial cells.
Hu Z, Linn N, Li Q, Zhang K, Liao J, Han Q, Zhang H, Guo J, Hu L, Pan J, Li Y, Tang Z
The Science of the total environment 2023 Feb 1;858(Pt 3):160157
The Science of the total environment 2023 Feb 1;858(Pt 3):160157
Quercetin alleviates cadmium-induced BRL-3A cell apoptosis by inhibiting oxidative stress and the PERK/IRE1α/ATF6 signaling pathway.
Ding L, Zhu H, Wang K, Huang R, Yu W, Yan B, Zhou B, Wang H, Yang Z, Liu Z, Wang J
Environmental science and pollution research international 2023 Dec;30(60):125790-125805
Environmental science and pollution research international 2023 Dec;30(60):125790-125805
Periplocin suppresses the growth of colorectal cancer cells by triggering LGALS3 (galectin 3)-mediated lysophagy.
Wang K, Fu S, Dong L, Zhang D, Wang M, Wu X, Shen E, Luo L, Li C, Nice EC, Huang C, Zou B
Autophagy 2023 Dec;19(12):3132-3150
Autophagy 2023 Dec;19(12):3132-3150
Sanghuangporus vaninii ethanol extract alleviates hyperuricemic renal injury by regulating the uric acid transporters and inhibiting HK-2 apoptosis.
Hua L, Zhang S, Yang J, Zhou X, Shi S
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Aug;164:114970
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Aug;164:114970
Glutamine and amino acid metabolism as a prognostic signature and therapeutic target in endometrial cancer.
Zhai L, Yang X, Cheng Y, Wang J
Cancer medicine 2023 Aug;12(15):16337-16358
Cancer medicine 2023 Aug;12(15):16337-16358
Inhibition of hyaluronic acid degradation pathway suppresses glioma progression by inducing apoptosis and cell cycle arrest.
Yan T, Yang H, Xu C, Liu J, Meng Y, Jiang Q, Li J, Kang G, Zhou L, Xiao S, Xue Y, Xu J, Chen X, Che F
Cancer cell international 2023 Aug 11;23(1):163
Cancer cell international 2023 Aug 11;23(1):163
Integrated Bioinformatic Analysis Reveals TXNRD1 as a Novel Biomarker and Potential Therapeutic Target in Idiopathic Pulmonary Arterial Hypertension.
Lin W, Tang Y, Zhang M, Liang B, Wang M, Zha L, Yu Z
Frontiers in medicine 2022;9:894584
Frontiers in medicine 2022;9:894584
The Selenium Yeast vs Selenium Methionine on Cell Viability, Selenoprotein Profile and Redox Status via JNK/ P38 Pathway in Porcine Mammary Epithelial Cells.
Wu C, Cui C, Zheng X, Wang J, Ma Z, Zhu P, Lin G, Zhang S, Guan W, Chen F
Frontiers in veterinary science 2022;9:850935
Frontiers in veterinary science 2022;9:850935
SS31 Ameliorates Oxidative Stress via the Restoration of Autophagic Flux to Protect Aged Mice From Hind Limb Ischemia.
Yang Q, Li C, Chen Q
Frontiers in cardiovascular medicine 2022;9:789331
Frontiers in cardiovascular medicine 2022;9:789331
Calvatia Lilacina Extracts Exert Anti-Breast-Cancer Bioactivity through the Apoptosis Induction Dependent on Mitochondrial Reactive Oxygen Species and Caspase Activation.
Zeng Q, Singh R, Ye Y, Cheng S, Fan C, Zeng Q
Nutrition and cancer 2022;74(3):1058-1070
Nutrition and cancer 2022;74(3):1058-1070
Network Pharmacology-Based Prediction and Verification of the Potential Targets of Pinoresinol Diglucoside for OA Treatment.
Lou H, Zhang Y, Fang J, Jin Y
Evidence-based complementary and alternative medicine : eCAM 2022;2022:9733742
Evidence-based complementary and alternative medicine : eCAM 2022;2022:9733742
Normothermic Ex Vivo Heart Perfusion with Mesenchymal Stem Cell-Derived Conditioned Medium Improves Myocardial Tissue Protection in Rat Donation after Circulatory Death Hearts.
Zeng Z, Xu L, Xu Y, Ruan Y, Liu D, Li J, Niu C, Zheng S, Zhou P, Xiao Z
Stem cells international 2022;2022:8513812
Stem cells international 2022;2022:8513812
Cryptotanshinone Protects against PCOS-Induced Damage of Ovarian Tissue via Regulating Oxidative Stress, Mitochondrial Membrane Potential, Inflammation, and Apoptosis via Regulating Ferroptosis.
Liu H, Xie J, Fan L, Xia Y, Peng X, Zhou J, Ni X
Oxidative medicine and cellular longevity 2022;2022:8011850
Oxidative medicine and cellular longevity 2022;2022:8011850
Wenhua Juanbi Recipe Attenuates Rheumatoid Arthritis via Inhibiting miRNA-146a-Mediated Autophagy.
Zhou H, Huang L, Zhan K, Liu X
BioMed research international 2022;2022:1768052
BioMed research international 2022;2022:1768052
Pseudoephedrine Nanoparticles Alleviate Adriamycin-Induced Reproductive Toxicity Through the GnRhR Signaling Pathway.
Fu Y, Yuan P, Zheng Y, Wei Y, Gao L, Ruan Y, Chen Y, Li P, Feng W, Zheng X
International journal of nanomedicine 2022;17:1549-1566
International journal of nanomedicine 2022;17:1549-1566
Effects of regenerative peripheral nerve interface on dorsal root ganglia neurons following peripheral axotomy.
Wang Z, Zhang D, Yi XZ, Zhao Y, Yu A
Frontiers in neuroscience 2022;16:914344
Frontiers in neuroscience 2022;16:914344
Exploration of the Effect and Potential Mechanism of Echinacoside Against Endometrial Cancer Based on Network Pharmacology and in vitro Experimental Verification.
Shu W, Wang Z, Zhao R, Shi R, Zhang J, Zhang W, Wang H
Drug design, development and therapy 2022;16:1847-1863
Drug design, development and therapy 2022;16:1847-1863
Sinomenine Confers Protection Against Myocardial Ischemia Reperfusion Injury by Preventing Oxidative Stress, Cellular Apoptosis, and Inflammation.
Xia B, Li Q, Wu J, Yuan X, Wang F, Lu X, Huang C, Zheng K, Yang R, Yin L, Liu K, You Q
Frontiers in pharmacology 2022;13:922484
Frontiers in pharmacology 2022;13:922484
SIRT1 Is Involved in the Neuroprotection of Pterostilbene Against Amyloid β 25-35-Induced Cognitive Deficits in Mice.
Zhu L, Lu F, Zhang X, Liu S, Mu P
Frontiers in pharmacology 2022;13:877098
Frontiers in pharmacology 2022;13:877098
Aloe-Emodin Induces Mitochondrial Dysfunction and Pyroptosis by Activation of the Caspase-9/3/Gasdermin E Axis in HeLa Cells.
Li T, Shi L, Liu W, Hu X, Hui Y, Di M, Xue S, Zheng Y, Yao M, Li C, Meng K
Frontiers in pharmacology 2022;13:854526
Frontiers in pharmacology 2022;13:854526
Pharmacological inhibition of SMYD2 protects against cisplatin-induced acute kidney injury in mice.
Cui B, Hou X, Liu M, Li Q, Yu C, Zhang S, Wang Y, Wang J, Zhuang S, Liu F
Frontiers in pharmacology 2022;13:829630
Frontiers in pharmacology 2022;13:829630
Cold Exposure Induces Intestinal Barrier Damage and Endoplasmic Reticulum Stress in the Colon via the SIRT1/Nrf2 Signaling Pathway.
Guo J, Hu H, Chen Z, Xu J, Nie J, Lu J, Ma L, Ji H, Yuan J, Xu B
Frontiers in physiology 2022;13:822348
Frontiers in physiology 2022;13:822348
Integrated network pharmacology and serum metabolomics approach deciphers the anti-colon cancer mechanisms of Huangqi Guizhi Wuwu Decoction.
Pan B, Xia Y, Fang S, Ai J, Wang K, Zhang J, Du C, Chen Y, Liu L, Yan S
Frontiers in pharmacology 2022;13:1043252
Frontiers in pharmacology 2022;13:1043252
Depletion of PARP10 inhibits the growth and metastatic potential of oral squamous cell carcinoma.
Zhou Z, Wei B, Liu Y, Liu T, Zeng S, Gan J, Qi G
Frontiers in genetics 2022;13:1035638
Frontiers in genetics 2022;13:1035638
Porcine cGAS-STING signaling induced autophagy inhibits STING downstream IFN and apoptosis.
Xia N, Zheng W, Jiang S, Cao Q, Luo J, Zhang J, Xu Y, Sun S, Zhang K, Chen N, Meurens F, Zhu J
Frontiers in immunology 2022;13:1021384
Frontiers in immunology 2022;13:1021384
Sleeve gastrectomy attenuated diabetes-related cognitive decline in diabetic rats.
Ding H, Liu C, Zhang S, Li B, Xu Q, Shi B, Li S, Dong S, Ma X, Zhang Y, Zhong M, Zhang G
Frontiers in endocrinology 2022;13:1015819
Frontiers in endocrinology 2022;13:1015819
BI 2536 induces gasdermin E-dependent pyroptosis in ovarian cancer.
Huo J, Shen Y, Zhang Y, Shen L
Frontiers in oncology 2022;12:963928
Frontiers in oncology 2022;12:963928
Synergistic effects of nab-PTX and anti-PD-1 antibody combination against lung cancer by regulating the Pi3K/AKT pathway through the Serpinc1 gene.
Zhang J, Tang Z, Guo X, Wang Y, Zhou Y, Cai W
Frontiers in oncology 2022;12:933646
Frontiers in oncology 2022;12:933646
Clinical Impact of the Histopathological Index and Neuroimaging Features Status in Primary Central Nervous System Diffuse Large B-Cell Lymphoma: A Single-Center Retrospective Analysis of 51 Cases.
Qi Z, Duan L, Yuan G, Liu J, Li J, Li G, Yu Y, Xu Y, Ma S, Pan Y, Zhang Y
Frontiers in oncology 2022;12:769895
Frontiers in oncology 2022;12:769895
Ring finger protein 128 promotes, rather than inhibits, colorectal cancer progression by regulating the Hippo signaling pathway.
Ning S, Chen Y, Wang G, Liu Y, Yang Y, Zhang Z
Frontiers in oncology 2022;12:1031160
Frontiers in oncology 2022;12:1031160
Calycosin suppresses colorectal cancer progression by targeting ERβ, upregulating PTEN, and inhibiting PI3K/Akt signal pathway.
Zhu L, Liu S, Liao YF, Sheng YM, He JC, Cai ZX, Man Q, Wu YY
Cell biology international 2022 Sep;46(9):1367-1377
Cell biology international 2022 Sep;46(9):1367-1377
Trehalose improves palmitic acid-induced apoptosis of osteoblasts by regulating SIRT3-medicated autophagy via the AMPK/mTOR/ULK1 pathway.
Cao L, Zhou S, Qiu X, Qiu S
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Sep;36(9):e22491
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Sep;36(9):e22491
TFAP2C Knockdown Sensitizes Bladder Cancer Cells to Cisplatin Treatment via Regulation of EGFR and NF-κB.
Xing J, Chen W, Chen K, Zhu S, Lin F, Qi Y, Zhang Y, Han S, Rao T, Ruan Y, Zhao S, Yu W, Cheng F
Cancers 2022 Sep 30;14(19)
Cancers 2022 Sep 30;14(19)
Nitidine chloride induces caspase 3/GSDME-dependent pyroptosis by inhibting PI3K/Akt pathway in lung cancer.
Yu F, Tan W, Chen Z, Shen X, Mo X, Mo X, He J, Deng Z, Wang J, Luo Z, Yang J
Chinese medicine 2022 Sep 29;17(1):115
Chinese medicine 2022 Sep 29;17(1):115
TCHis mitigate oxidative stress and improve abnormal behavior in a prenatal valproic acid-exposed rat model of autism.
Jian J, Li LG, Zhao PJ, Zheng RJ, Dong XW, Zhao YH, Yin BQ, Cheng H, Li HL, Li EY
Physiological genomics 2022 Sep 1;54(9):325-336
Physiological genomics 2022 Sep 1;54(9):325-336
Injectable and reactive oxygen species-scavenging gelatin hydrogel promotes neural repair in experimental traumatic brain injury.
Zhang D, Chang R, Ren Y, He Y, Guo S, Guan F, Yao M
International journal of biological macromolecules 2022 Oct 31;219:844-863
International journal of biological macromolecules 2022 Oct 31;219:844-863
Circulating small extracellular vesicle-encapsulated SEMA5A-IT1 attenuates myocardial ischemia-reperfusion injury after cardiac surgery with cardiopulmonary bypass.
Wu T, Shi G, Ji Z, Wang S, Geng L, Guo Z
Cellular & molecular biology letters 2022 Oct 25;27(1):95
Cellular & molecular biology letters 2022 Oct 25;27(1):95
Effect of muscone on anti-apoptotic ability of muskrat prostate primary cells.
Zhang Y, Zhao X, Man X, Ma Y, Zhang W, Wang Y, Lei X, Bai S
American journal of physiology. Regulatory, integrative and comparative physiology 2022 Oct 1;323(4):R571-R580
American journal of physiology. Regulatory, integrative and comparative physiology 2022 Oct 1;323(4):R571-R580
Promotion of tumor progression induced by continuous low-dose administration of antineoplastic agent gemcitabine or gemcitabine combined with cisplatin.
Chen Y, Liu H, Zheng Q, Li H, You H, Feng Y, Feng W
Life sciences 2022 Oct 1;306:120826
Life sciences 2022 Oct 1;306:120826
CCT4 knockdown enhances the sensitivity of cisplatin by inhibiting glycolysis in human esophageal squamous cell carcinomas.
Fang J, Ma Y, Li Y, Li J, Zhang X, Han X, Ma S, Guan F
Molecular carcinogenesis 2022 Nov;61(11):1043-1055
Molecular carcinogenesis 2022 Nov;61(11):1043-1055
RNA binding motif protein 3 (RBM3) promotes protein kinase B (AKT) activation to enhance glucose metabolism and reduce apoptosis in skeletal muscle of mice under acute cold exposure.
Liu Y, Shi H, Hu Y, Yao R, Liu P, Yang Y, Li S
Cell stress & chaperones 2022 Nov;27(6):603-618
Cell stress & chaperones 2022 Nov;27(6):603-618
A novel inhibitor of ARfl and ARv7 induces protein degradation to overcome enzalutamide resistance in advanced prostate cancer.
Li Y, Chu Y, Shi G, Wang X, Ye W, Shan C, Wang D, Zhang D, He W, Jiang J, Ma S, Han Y, Zhao Z, Du S, Chen Z, Li Z, Yang Y, Wang C, Xu X, Wu H
Acta pharmaceutica Sinica. B 2022 Nov;12(11):4165-4179
Acta pharmaceutica Sinica. B 2022 Nov;12(11):4165-4179
Capsaicin suppresses hepatocarcinogenesis by inhibiting the stemness of hepatic progenitor cells via SIRT1/SOX2 signaling pathway.
Xie ZQ, Li HX, Hou XJ, Huang MY, Zhu ZM, Wei LX, Tang CX
Cancer medicine 2022 Nov;11(22):4283-4296
Cancer medicine 2022 Nov;11(22):4283-4296
Integrated metabolomics, network pharmacology and biological verification to reveal the mechanisms of Nauclea officinalis treatment of LPS-induced acute lung injury.
Xu H, Xu S, Li L, Wu Y, Mai S, Xie Y, Tan Y, Li A, Xue F, He X, Li Y
Chinese medicine 2022 Nov 24;17(1):131
Chinese medicine 2022 Nov 24;17(1):131
6-Shogaol Exhibits a Promoting Effect with Tax via Binding HSP60 in Non-Small-Cell Lung Cancer.
Mulati S, Jiang R, Wang J, Tao Y, Zhang W
Cells 2022 Nov 19;11(22)
Cells 2022 Nov 19;11(22)
Blocking PARP activity with the inhibitor veliparib enhances radiotherapy sensitivity in endometrial carcinoma.
Wang J, Xing W, Lin Y, Uskenbayeva N, Yan H, Xu Y, Fang L
Journal of clinical laboratory analysis 2022 May;36(5):e24435
Journal of clinical laboratory analysis 2022 May;36(5):e24435
Protective Effect of Resveratrol on Immortalized Duck Intestinal Epithelial Cells Exposed to H(2)O(2).
Zhou N, Tian Y, Wu H, Cao Y, Li R, Zou K, Xu W, Lu L
Molecules (Basel, Switzerland) 2022 May 31;27(11)
Molecules (Basel, Switzerland) 2022 May 31;27(11)
Hernandezine Regulates Proliferation and Autophagy-Induced Apoptosis in Melanoma Cells.
Wang X, Li X, Xia Y, Wang D, Li X, Liu L, Zheng Q, Li D, Jiang Q
Journal of natural products 2022 May 27;85(5):1351-1362
Journal of natural products 2022 May 27;85(5):1351-1362
Discovery of 4-Hydroxyquinazoline Derivatives as Small Molecular BET/PARP1 Inhibitors That Induce Defective Homologous Recombination and Lead to Synthetic Lethality for Triple-Negative Breast Cancer Therapy.
Zhang J, Yang C, Tang P, Chen J, Zhang D, Li Y, Yang G, Liu Y, Zhang Y, Wang Y, Liu J, Ouyang L
Journal of medicinal chemistry 2022 May 12;65(9):6803-6825
Journal of medicinal chemistry 2022 May 12;65(9):6803-6825
Inhibition of Ras protein activator like 2 produces antitumor effects in gastric cancer via the suppression of YAP1 activation.
Hu Y, Zhang P, Shi Y, Dong X, Wu Y, Dong D, Li E, Fan Y
Environmental toxicology 2022 Mar;37(3):527-538
Environmental toxicology 2022 Mar;37(3):527-538
Mechanism of a new photosensitizer (TBZPy) in the treatment of high-risk human papillomavirus-related diseases.
Li Z, Xiao Z, Feng Y, Wang Q, Teng M
Photodiagnosis and photodynamic therapy 2022 Mar;37:102591
Photodiagnosis and photodynamic therapy 2022 Mar;37:102591
Effects of Ganfule capsule on microbial and metabolic profiles in anti-hepatocellular carcinoma.
Xu F, Li H, Pan Y, Zeng Y, Li J, Li S
Journal of applied microbiology 2022 Mar;132(3):2280-2292
Journal of applied microbiology 2022 Mar;132(3):2280-2292
Clinical significance of mitogen-activated protein kinase kinase kinases in hepatitis B virus -related hepatocellular carcinoma and underlying mechanism exploration.
Liu Z, Zhou X, Zheng P, Bu C, Yan X, Yu H, Xu Y
Bioengineered 2022 Mar;13(3):6819-6838
Bioengineered 2022 Mar;13(3):6819-6838
Upregulation of BRD7 protects podocytes against high glucose-induced apoptosis by enhancing Nrf2 in a GSK-3β-dependent manner.
Yu X, Jiang N, Li J, Li X, He S
Tissue & cell 2022 Jun;76:101813
Tissue & cell 2022 Jun;76:101813
β-Elemene induces apoptosis by activating the P53 pathway in human hypertrophic scar fibroblasts.
Guo Q, Li Y, Chen Y, Ji J, Zheng S, Xu X, Zhang B, Ye J
IUBMB life 2022 Jun;74(6):508-518
IUBMB life 2022 Jun;74(6):508-518
LncDACH1 promotes mitochondrial oxidative stress of cardiomyocytes by interacting with sirtuin3 and aggravates diabetic cardiomyopathy.
Zhang Q, Li D, Dong X, Zhang X, Liu J, Peng L, Meng B, Hua Q, Pei X, Zhao L, Hu X, Zhang Y, Pan Z, Lu Y, Yang B
Science China. Life sciences 2022 Jun;65(6):1198-1212
Science China. Life sciences 2022 Jun;65(6):1198-1212
High Expression of C8orf76 Is an Independent Predictive Factor of Poor Prognosis in Patients with Breast Cancer.
Wang Y, Dong X
Advances in therapy 2022 Jun;39(6):2946-2960
Advances in therapy 2022 Jun;39(6):2946-2960
Protection of pancreatic β-cell by phosphocreatine through mitochondrial improvement via the regulation of dual AKT/IRS-1/GSK-3β and STAT3/Cyp-D signaling pathways.
Wang H, Ai J, Shopit A, Niu M, Ahmed N, Tesfaldet T, Tang Z, Li X, Jamalat Y, Chu P, Peng J, Ma X, Qaed E, Han G, Zhang W, Wang J, Tang Z
Cell biology and toxicology 2022 Jun;38(3):531-551
Cell biology and toxicology 2022 Jun;38(3):531-551
Activation of CXCL13/CXCR5 axis aggravates experimental autoimmune cystitis and interstitial cystitis/bladder pain syndrome.
Zhao J, Chen S, Yang C, Zhou M, Yang T, Sun B, Zhu J, Zhang H, Lu Q, Li L, Yang Z, Song B, Shen W, Yi S, Dai S
Biochemical pharmacology 2022 Jun;200:115047
Biochemical pharmacology 2022 Jun;200:115047
Qi-Tai-Suan, an oleanolic acid derivative, ameliorates ischemic heart failure via suppression of cardiac apoptosis, inflammation and fibrosis.
Qian M, Feng ZQ, Zheng RN, Hu KW, Sun JZ, Sun HB, Dai L
Chinese journal of natural medicines 2022 Jun;20(6):432-442
Chinese journal of natural medicines 2022 Jun;20(6):432-442
Ephedra herb reduces adriamycin-induced testicular toxicity by upregulating the gonadotropin-releasing hormone signalling pathway.
Fu Y, Yuan P, Zheng Y, Gao L, Wei Y, Chen Y, Li P, Ruan Y, Zheng X, Feng W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jun;150:113061
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Jun;150:113061
The role of ER stress and ATP/AMPK in oxidative stress meditated hepatotoxicity induced by citrinin.
Wu J, Yang C, Yang M, Liang Z, Wu Y, Kong X, Fan H, Wang S, Ning C, Xiao W, Jin Y, Yi J, Yuan Z
Ecotoxicology and environmental safety 2022 Jun 1;237:113531
Ecotoxicology and environmental safety 2022 Jun 1;237:113531
Patient-derived microphysiological model identifies the therapeutic potential of metformin for thoracic aortic aneurysm.
Ma W, Zhang J, Liu S, Yan S, Xu K, Zhang YS, Abudupataer M, Ming Y, Zhu S, Xiang B, Zhou X, Luo S, Huang H, Tang Y, Zhang S, Xie Z, Chen N, Sun X, Li J, Lai H, Wang C, Zhu K, Zhang W
EBioMedicine 2022 Jul;81:104080
EBioMedicine 2022 Jul;81:104080
Bunyavirus SFTSV exploits autophagic flux for viral assembly and egress.
Yan JM, Zhang WK, Yan LN, Jiao YJ, Zhou CM, Yu XJ
Autophagy 2022 Jul;18(7):1599-1612
Autophagy 2022 Jul;18(7):1599-1612
Perilipin 5 protects against oxygen-glucose deprivation/reoxygenation-elicited neuronal damage by inhibiting oxidative stress and inflammatory injury via the Akt-GSK-3β-Nrf2 pathway.
Huo K, Ma KG, Guo QY, Duan P, Xu J
International immunopharmacology 2022 Jul;108:108718
International immunopharmacology 2022 Jul;108:108718
Cancer cells corrupt normal epithelial cells through miR-let-7c-rich small extracellular vesicle-mediated downregulation of p53/PTEN.
Liang W, Chen Y, Liu H, Zhao H, Luo T, Tang H, Zhou X, Jiang E, Shao Z, Liu K, Shang Z
International journal of oral science 2022 Jul 19;14(1):36
International journal of oral science 2022 Jul 19;14(1):36
Alnustone inhibits the growth of hepatocellular carcinoma via ROS- mediated PI3K/Akt/mTOR/p70S6K axis.
Wang L, Cheng L, Ma L, Ahmad Farooqi A, Qiao G, Zhang Y, Ye H, Liu M, Huang J, Yang X, Lin X, Cao S
Phytotherapy research : PTR 2022 Jan;36(1):525-542
Phytotherapy research : PTR 2022 Jan;36(1):525-542
Radiocontrast agent and intraductal pressure promote the progression of post-ERCP pancreatitis by regulating inflammatory response, cellular apoptosis, and tight junction integrity.
Zhang D, Man X, Li L, Tang J, Liu F
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2022 Jan;22(1):74-82
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2022 Jan;22(1):74-82
Extracorporeal shockwave relieves endothelial injury and dysfunction in steroid-induced osteonecrosis of the femoral head via miR-135b targeting FOXO1: in vitro and in vivo studies.
Wu X, Wang Y, Fan X, Xu X, Sun W
Aging 2022 Jan 7;14(1):410-429
Aging 2022 Jan 7;14(1):410-429
Hyaluronic Acid-Modified Nanoparticles Self-Assembled from Linoleic Acid-Conjugated Chitosan for the Codelivery of miR34a and Doxorubicin in Resistant Breast Cancer.
Yang X, Shang P, Ji J, Malichewe C, Yao Z, Liao J, Du D, Sun C, Wang L, Tang YJ, Guo X
Molecular pharmaceutics 2022 Jan 3;19(1):2-17
Molecular pharmaceutics 2022 Jan 3;19(1):2-17
STAT3 exerts pro-tumor and anti-autophagy roles in cervical cancer.
Wu L, Shen B, Li J, Zhang H, Zhang K, Yang Y, Zu Z, Shen D, Luo M
Diagnostic pathology 2022 Jan 20;17(1):13
Diagnostic pathology 2022 Jan 20;17(1):13
Porcine TRIM21 Enhances Porcine Circovirus 2 Infection and Host Immune Responses, But Inhibits Apoptosis of PCV2-Infected Cells.
Yang L, Liu X, Zhang L, Li X, Zhang X, Niu G, Ji W, Chen S, Ouyang H, Ren L
Viruses 2022 Jan 15;14(1)
Viruses 2022 Jan 15;14(1)
Muyin extract inhibits non-small-cell lung cancer growth by inducing autophagy and apoptosis in vitro and in vivo.
Kan Y, Song M, Cui X, Yang Q, Zang Y, Li Q, Li Y, Cai W, Chen Y, Weng X, Wang Y, Zhu X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Feb;96:153834
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Feb;96:153834
Attenuation of hepatic ischemia‑reperfusion injury by adipose stem cell‑derived exosome treatment via ERK1/2 and GSK‑3β signaling pathways.
Zhang Y, Li Y, Wang Q, Zheng D, Feng X, Zhao W, Cai L, Zhang Q, Xu H, Fu H
International journal of molecular medicine 2022 Feb;49(2)
International journal of molecular medicine 2022 Feb;49(2)
Hydroxysafflor yellow A attenuates oxidative stress injury-induced apoptosis in the nucleus pulposus cell line and regulates extracellular matrix balance via CA XII.
Yang S, Liao W
Experimental and therapeutic medicine 2022 Feb;23(2):182
Experimental and therapeutic medicine 2022 Feb;23(2):182
Cardiotoxicity of patulin was found in H9c2 cells.
Zhang B, Liang H, Huang K, Li J, Xu D, Huang C, Li Y
Toxicon : official journal of the International Society on Toxinology 2022 Feb;207:21-30
Toxicon : official journal of the International Society on Toxinology 2022 Feb;207:21-30
RETRACTED: TRIM21 deficiency confers protection from OGD/R-induced oxidative and inflammatory damage in cultured hippocampal neurons through regulation of the Keap1/Nrf2 pathway.
Fu Y, Gao J, Li Y, Yang X, Zhang Y
International immunopharmacology 2022 Feb;103:108414
International immunopharmacology 2022 Feb;103:108414
Danggui Niantong granules ameliorate rheumatoid arthritis by regulating intestinal flora and promoting mitochondrial apoptosis.
Lu QJ, Li JY, Lin HX, Cai YS, Liu CS, Fu LP, Liu G, Yuan LX
Pharmaceutical biology 2022 Dec;60(1):1606-1615
Pharmaceutical biology 2022 Dec;60(1):1606-1615
PRRX1 promotes colorectal cancer stemness and chemoresistance via the JAK2/STAT3 axis by targeting IL-6.
Zhong L, Tan W, Yang Q, Zou Z, Zhou R, Huang Y, Qiu Z, Zheng K, Huang Z
Journal of gastrointestinal oncology 2022 Dec;13(6):2989-3008
Journal of gastrointestinal oncology 2022 Dec;13(6):2989-3008
Hsa_circ_0005050 interacts with ILF3 and affects cell apoptosis and proliferation by disrupting the balance between p53 and p65.
Tan J, Sun M, Yin J, Zhou Q, Zhao R, Chen Q, Sun H, Jiang C, Li S, He Y
Chemico-biological interactions 2022 Dec 1;368:110208
Chemico-biological interactions 2022 Dec 1;368:110208
Novel shikonin derivatives suppress cell proliferation, migration and induce apoptosis in human triple-negative breast cancer cells via regulating PDK1/PDHC axis.
Chen Q, Han H, Lin F, Yang L, Feng L, Lai X, Wen Z, Yang M, Wang C, Ma Y, Yin T, Lu G, Lin H, Qi J, Yang Y
Life sciences 2022 Dec 1;310:121077
Life sciences 2022 Dec 1;310:121077
Fucoidan ameliorates LPS-induced neuronal cell damage and cognitive impairment in mice.
Wang Y, Wang Q, Duan L, Li X, Yang W, Huang T, Kong M, Guan F, Ma S
International journal of biological macromolecules 2022 Dec 1;222(Pt A):759-771
International journal of biological macromolecules 2022 Dec 1;222(Pt A):759-771
IL-18BP Improves Early Graft Function and Survival in Lewis-Brown Norway Rat Orthotopic Liver Transplantation Model.
Meng Q, Wu W, Zhang W, Yuan J, Yang L, Zhang X, Tao K
Biomolecules 2022 Dec 1;12(12)
Biomolecules 2022 Dec 1;12(12)
Mecheliolide elicits ROS-mediated ERS driven immunogenic cell death in hepatocellular carcinoma.
Xu Z, Xu J, Sun S, Lin W, Li Y, Lu Q, Li F, Yang Z, Lu Y, Liu W
Redox biology 2022 Aug;54:102351
Redox biology 2022 Aug;54:102351
Higher efficacy of resveratrol against advanced breast cancer organoids: A comparison with that of clinically relevant drugs.
Ye HS, Gao HF, Li H, Nie JH, Li TT, Lu MD, Wu ML, Liu J, Wang K
Phytotherapy research : PTR 2022 Aug;36(8):3313-3324
Phytotherapy research : PTR 2022 Aug;36(8):3313-3324
Osteocytic cells exposed to titanium particles increase sclerostin expression and inhibit osteoblastic cell differentiation mostly via direct cell-to-cell contact.
Chai H, Zhang ZH, Fang JY, She C, Geng C, Xu W
Journal of cellular and molecular medicine 2022 Aug;26(15):4371-4385
Journal of cellular and molecular medicine 2022 Aug;26(15):4371-4385
Role of endoplasmic reticulum stress in cadmium-induced hepatocyte apoptosis and the protective effect of quercetin.
Wang J, Ding L, Wang K, Huang R, Yu W, Yan B, Wang H, Zhang C, Yang Z, Liu Z
Ecotoxicology and environmental safety 2022 Aug;241:113772
Ecotoxicology and environmental safety 2022 Aug;241:113772
Dapagliflozin Improves Cardiac Function, Remodeling, Myocardial Apoptosis, and Inflammatory Cytokines in Mice with Myocardial Infarction.
Wang K, Li Z, Sun Y, Liu X, Ma W, Ding Y, Hong J, Qian L, Xu D
Journal of cardiovascular translational research 2022 Aug;15(4):786-796
Journal of cardiovascular translational research 2022 Aug;15(4):786-796
The surface morphology of Platycodon grandiflorus polysaccharide and its anti-apoptotic effect by targeting autophagy.
Cheng G, Zhang S, Lv M, Qi C, Fan R, Guo X, Liu J, Zhao X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Aug;103:154212
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Aug;103:154212
Mesenchymal stem cells-derived exosomes prevent sepsis-induced myocardial injury by a CircRTN4/miR-497-5p/MG53 pathway.
Li J, Jiang R, Hou Y, Lin A
Biochemical and biophysical research communications 2022 Aug 27;618:133-140
Biochemical and biophysical research communications 2022 Aug 27;618:133-140
Netrin-1 induces the anti-apoptotic and pro-survival effects of B-ALL cells through the Unc5b-MAPK axis.
Huang L, An X, Zhu Y, Zhang K, Xiao L, Yao X, Zeng X, Liang S, Yu J
Cell communication and signaling : CCS 2022 Aug 16;20(1):122
Cell communication and signaling : CCS 2022 Aug 16;20(1):122
Dihydroartemisinin enhances the anti-tumor activity of oxaliplatin in colorectal cancer cells by altering PRDX2-reactive oxygen species-mediated multiple signaling pathways.
Yu Y, Chen D, Wu T, Lin H, Ni L, Sui H, Xiao S, Wang C, Jiang S, Pan H, Li S, Jin X, Xie C, Cui R
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Apr;98:153932
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Apr;98:153932
CCAAT/Enhancer-Binding Protein Homologous Protein (CHOP) Deficiency Attenuates Heatstroke-Induced Intestinal Injury.
Cao Y, Fan M, Pei Y, Su L, Xiao W, Chen F, Huang J, Liu X, Gu Z, Zhang Z, Yuan F, Jiang Y, Han X
Inflammation 2022 Apr;45(2):695-711
Inflammation 2022 Apr;45(2):695-711
Oxycodone protects cardiac microvascular endothelial cells against ischemia/reperfusion injury by binding to Sigma-1 Receptor.
Ji M, Cheng J, Zhang D
Bioengineered 2022 Apr;13(4):9628-9644
Bioengineered 2022 Apr;13(4):9628-9644
A novel promoter-associated non-coding small RNA paGLI1 recruits FUS/P65 to transactivate GLI1 gene expression and promotes infiltrating glioma progression.
Zhong J, Xu M, Su Z, Zhang M, Yu T, Nie L, Gong J, Chen X, Chen N, Zhou Q
Cancer letters 2022 Apr 1;530:68-84
Cancer letters 2022 Apr 1;530:68-84
CDK5RAP3 acts as a putative tumor inhibitor in papillary thyroid carcinoma via modulation of Akt/GSK-3β/Wnt/β-catenin signaling.
Feng X, Jiang J, Sun L, Zhou Q
Toxicology and applied pharmacology 2022 Apr 1;440:115940
Toxicology and applied pharmacology 2022 Apr 1;440:115940
Cold-Induced RNA-Binding Protein Promotes Glucose Metabolism and Reduces Apoptosis by Increasing AKT Phosphorylation in Mouse Skeletal Muscle Under Acute Cold Exposure.
Liu Y, Liu P, Hu Y, Cao Y, Lu J, Yang Y, Lv H, Lian S, Xu B, Li S
Frontiers in molecular biosciences 2021;8:685993
Frontiers in molecular biosciences 2021;8:685993
Cannabisin D from Sinomenium Acutum Inhibits Proliferation and Migration of Glioblastoma Cells through MAPKs Signaling.
Zhang D, Li C, Zhang L, Li B, Wang Y, Wang R, Chen Z, Xu L, Liu T
Nutrition and cancer 2021;73(11-12):2491-2501
Nutrition and cancer 2021;73(11-12):2491-2501
Expression of Ubiquitin-specific protease 7 in oral squamous cell carcinoma promotes tumor cell proliferation and invasion.
Yang X, Jin J, Yang J, Zhou L, Mi S, Qi G
Genetics and molecular biology 2021;44(4):e20210058
Genetics and molecular biology 2021;44(4):e20210058
Farrerol Enhances Nrf2-Mediated Defense Mechanisms against Hydrogen Peroxide-Induced Oxidative Damage in Human Retinal Pigment Epithelial Cells by Activating Akt and MAPK.
Ma N, Yang X, Qi C, Yu Q, Zhu C, Ren H
Oxidative medicine and cellular longevity 2021;2021:8847844
Oxidative medicine and cellular longevity 2021;2021:8847844
Melatonin Alleviates Contrast-Induced Acute Kidney Injury by Activation of Sirt3.
Zhang C, Suo M, Liu L, Qi Y, Zhang C, Xie L, Zheng X, Ma C, Li J, Yang J, Bu P
Oxidative medicine and cellular longevity 2021;2021:6668887
Oxidative medicine and cellular longevity 2021;2021:6668887
Tunicamycin-Induced Endoplasmic Reticulum Stress Promotes Breast Cancer Cell MDA-MB-231 Apoptosis through Inhibiting Wnt/β-Catenin Signaling Pathway.
You Z, He L, Yan N
Journal of healthcare engineering 2021;2021:6394514
Journal of healthcare engineering 2021;2021:6394514
Bioactive Peptide F2d Isolated from Rice Residue Exerts Antioxidant Effects via Nrf2 Signaling Pathway.
Liu J, Wu Q, Yang T, Yang F, Guo T, Zhou Y, Han S, Luo Y, Guo T, Luo F, Lin Q
Oxidative medicine and cellular longevity 2021;2021:2637577
Oxidative medicine and cellular longevity 2021;2021:2637577
Therapeutic Efficacy of Carbon Ion Irradiation Enhanced by 11-MUA-Capped Gold Nanoparticles: An in vitro and in vivo Study.
Zhang P, Yu B, Jin X, Zhao T, Ye F, Liu X, Li P, Zheng X, Chen W, Li Q
International journal of nanomedicine 2021;16:4661-4674
International journal of nanomedicine 2021;16:4661-4674
TFEB promotes BCL-2 expression by upregulating its promoter activity in the t(6;11) translocation renal cell carcinomas.
Zhan HQ, Qin R, Li YL, Liu MM, Gan L
American journal of translational research 2021;13(8):8804-8818
American journal of translational research 2021;13(8):8804-8818
Elevated HNF1A expression promotes radiation-resistance via driving PI3K/AKT signaling pathway in esophageal squamous cell carcinoma cells.
Zou N, Zhang X, Li S, Li Y, Zhao Y, Yang X, Zhu S
Journal of Cancer 2021;12(16):5013-5024
Journal of Cancer 2021;12(16):5013-5024
MicroRNA-455-5p Contributes to Cholangiocarcinoma Growth and Mediates Galangin's Anti-Tumor Effects.
Deng X, Zuo M, Pei Z, Xie Y, Yang Z, Zhang Z, Jiang M, Kuang D
Journal of Cancer 2021;12(15):4710-4721
Journal of Cancer 2021;12(15):4710-4721
Inhibition of SPATS2 Suppresses Proliferation and Invasion of Hepatocellular Carcinoma Cells through TRIM44-STAT3 Signaling Pathway.
Chen L, Yi C, Li W, Tseng Y, Zhang J, Liu J
Journal of Cancer 2021;12(1):89-98
Journal of Cancer 2021;12(1):89-98
Sonodynamic Effects of a Novel Ether-Group Modified Porphyrin Derivative Combined With Pulsed Low-Intensity Ultrasound on PC-9 Cells.
Jin Y, Zhou Q, Geng J, Meng Q, Wei Z, Ding M, Zhou J, Zeng Y, Cao W, Liu F, Yu Y
Frontiers in pharmacology 2021;12:792360
Frontiers in pharmacology 2021;12:792360
Characterization of Kinesin Family Member 2C as a Proto-Oncogene in Cervical Cancer.
Yang J, Wu Z, Yang L, Jeong JH, Zhu Y, Lu J, Wang B, Wang N, Wang Y, Shen K, Li R
Frontiers in pharmacology 2021;12:785981
Frontiers in pharmacology 2021;12:785981
miR-25 Regulates Gastric Cancer Cell Growth and Apoptosis by Targeting EGR2.
Yang L, Li L, Chang P, Wei M, Chen J, Zhu C, Jia J
Frontiers in genetics 2021;12:690196
Frontiers in genetics 2021;12:690196
Elevated Serum FGG Levels Prognosticate and Promote the Disease Progression in Prostate Cancer.
Peng HH, Wang JN, Xiao LF, Yan M, Chen SP, Wang L, Yang K
Frontiers in genetics 2021;12:651647
Frontiers in genetics 2021;12:651647
Downregulation of miR-135b-5p Suppresses Progression of Esophageal Cancer and Contributes to the Effect of Cisplatin.
Di Y, Jiang Y, Shen X, Liu J, Gao Y, Cai H, Sun X, Ning D, Liu B, Lei J, Jin S
Frontiers in oncology 2021;11:679348
Frontiers in oncology 2021;11:679348
Endoplasmic reticulum stress is involved in retinal injury induced by repeated transient spikes of intraocular pressure.
Yang X, Yu X, Zhao Z, He Y, Zhang J, Su X, Sun N, Fan Z
Journal of Zhejiang University. Science. B 2021 Sept 15;22(9):746-756
Journal of Zhejiang University. Science. B 2021 Sept 15;22(9):746-756
Sodium alginate/collagen/stromal cell-derived factor-1 neural scaffold loaded with BMSCs promotes neurological function recovery after traumatic brain injury.
Ma S, Zhou J, Huang T, Zhang Z, Xing Q, Zhou X, Zhang K, Yao M, Cheng T, Wang X, Wen X, Guan F
Acta biomaterialia 2021 Sep 1;131:185-197
Acta biomaterialia 2021 Sep 1;131:185-197
Interleukin-38 Suppresses Cell Migration and Proliferation and Promotes Apoptosis of Colorectal Cancer Cell Through Negatively Regulating Extracellular Signal-Regulated Kinases Signaling.
Huang L, Zhang H, Zhao D, Hu H, Lu Z
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2021 Oct;41(10):375-384
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2021 Oct;41(10):375-384
TSPAN1 promotes autophagy flux and mediates cooperation between WNT-CTNNB1 signaling and autophagy via the MIR454-FAM83A-TSPAN1 axis in pancreatic cancer.
Zhou C, Liang Y, Zhou L, Yan Y, Liu N, Zhang R, Huang Y, Wang M, Tang Y, Ali DW, Wang Y, Michalak M, Chen XZ, Tang J
Autophagy 2021 Oct;17(10):3175-3195
Autophagy 2021 Oct;17(10):3175-3195
Inhibition of autophagy with Chloroquine enhanced apoptosis induced by 5-aminolevulinic acid-photodynamic therapy in secondary hyperparathyroidism primary cells and organoids.
Zeng L, Zou Q, Huang P, Xiong L, Cheng Y, Chen Q, Li Y, He H, Yi W, Wei W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Oct;142:111994
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Oct;142:111994
Inhibition of JAK2/STAT3 signaling pathway by panaxadiol limits the progression of pancreatic cancer.
Fan X, Fu H, Xie N, Guo H, Fu T, Shan Y
Aging 2021 Oct 8;13(19):22830-22842
Aging 2021 Oct 8;13(19):22830-22842
Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.
Zhao Y, Liu X, Zheng Y, Liu W, Ding C
Scientific reports 2021 Oct 18;11(1):20558
Scientific reports 2021 Oct 18;11(1):20558
Switch receptor T3/28 improves long-term persistence and antitumor efficacy of CAR-T cells.
Zhao S, Wang C, Lu P, Lou Y, Liu H, Wang T, Yang S, Bao Z, Han L, Liang X, Ma C, Gao L
Journal for immunotherapy of cancer 2021 Nov;9(12)
Journal for immunotherapy of cancer 2021 Nov;9(12)
m(6)A-mediated upregulation of AC008 promotes osteoarthritis progression through the miR-328-3p‒AQP1/ANKH axis.
Yang J, Zhang M, Yang D, Ma Y, Tang Y, Xing M, Li L, Chen L, Jin Y, Ma C
Experimental & molecular medicine 2021 Nov;53(11):1723-1734
Experimental & molecular medicine 2021 Nov;53(11):1723-1734
The inhibitory effect Polygonum Cillinerve polysaccharide on transmissible gastroenteritis virus of swine.
Pan X, Zhou Y, Duan X, Cui J, Liu J, Song X, Ma W, Zhang W, Liu Y, Fan Y
Research in veterinary science 2021 Nov;140:47-55
Research in veterinary science 2021 Nov;140:47-55
Protocatechuic aldehyde protects cardiomycoytes against ischemic injury via regulation of nuclear pyruvate kinase M2.
Wu X, Liu L, Zheng Q, Hao H, Ye H, Li P, Yang H
Acta pharmaceutica Sinica. B 2021 Nov;11(11):3553-3566
Acta pharmaceutica Sinica. B 2021 Nov;11(11):3553-3566
Morphine promotes the malignant biological behavior of non-small cell lung cancer cells through the MOR/Src/mTOR pathway.
Liu X, Yang J, Yang C, Huang X, Han M, Kang F, Li J
Cancer cell international 2021 Nov 25;21(1):622
Cancer cell international 2021 Nov 25;21(1):622
Grape Seed Proanthocyanidin Ameliorates FB(1)-Induced Meiotic Defects in Porcine Oocytes.
Li W, He Y, Zhao H, Peng L, Li J, Rui R, Ju S
Toxins 2021 Nov 25;13(12)
Toxins 2021 Nov 25;13(12)
ACE Inhibitory Peptide from Skin Collagen Hydrolysate of Takifugu bimaculatus as Potential for Protecting HUVECs Injury.
Cai S, Pan N, Xu M, Su Y, Qiao K, Chen B, Zheng B, Xiao M, Liu Z
Marine drugs 2021 Nov 24;19(12)
Marine drugs 2021 Nov 24;19(12)
Ampelopsin Inhibits Breast Cancer Cell Growth through Mitochondrial Apoptosis Pathway.
Li Y, Zhou Y, Wang M, Lin X, Zhang Y, Laurent I, Zhong Y, Li J
Biological & pharmaceutical bulletin 2021 Nov 1;44(11):1738-1745
Biological & pharmaceutical bulletin 2021 Nov 1;44(11):1738-1745
Sodium cantharidate induces Apoptosis in breast cancer cells by regulating energy metabolism via the protein phosphatase 5-p53 axis.
Pang JL, Huang FH, Zhang YH, Wu Y, Ge XM, Li S, Li X
Toxicology and applied pharmacology 2021 Nov 1;430:115726
Toxicology and applied pharmacology 2021 Nov 1;430:115726
Methylation gene KCNC1 is associated with overall survival in patients with seminoma.
Chen S, Xiao L, Peng H, Wang Z, Xie J
Oncology reports 2021 May;45(5)
Oncology reports 2021 May;45(5)
IL‑33/ST2 promotes the malignant progression of gastric cancer via the MAPK pathway.
Huang N, Cui X, Li W, Zhang C, Liu L, Li J
Molecular medicine reports 2021 May;23(5)
Molecular medicine reports 2021 May;23(5)
20(S)-ginsenoside Rh2 induces caspase-dependent promyelocytic leukemia-retinoic acid receptor A degradation in NB4 cells via Akt/Bax/caspase9 and TNF-α/caspase8 signaling cascades.
Zhu S, Liu X, Xue M, Li Y, Cai D, Wang S, Zhang L
Journal of ginseng research 2021 Mar;45(2):295-304
Journal of ginseng research 2021 Mar;45(2):295-304
Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway.
Gao X, Wang Y, Lu F, Chen X, Yang D, Cao Y, Zhang W, Chen J, Zheng L, Wang G, Fu M, Ma L, Song Y, Zhan Q
Journal of extracellular vesicles 2021 Mar;10(5):e12060
Journal of extracellular vesicles 2021 Mar;10(5):e12060
FAM122A promotes acute myeloid leukemia cell growth through inhibiting PP2A activity and sustaining MYC expression.
Liu MH, Chen J, Yang YS, Wang YQ, Chen GQ, Zhang Y, Huang Y
Haematologica 2021 Mar 1;106(3):903-907
Haematologica 2021 Mar 1;106(3):903-907
Iguratimod-encapsulating PLGA-NPs induce human multiple myeloma cell death via reactive oxygen species and Caspase-dependent signalling.
Wang F, Younis M, Luo Y, Zhang L, Yuan L
International immunopharmacology 2021 Jun;95:107532
International immunopharmacology 2021 Jun;95:107532
Sparstolonin B exerts beneficial effects on prostate cancer by acting on the reactive oxygen species-mediated PI3K/AKT pathway.
Liu S, Hu J, Shi C, Sun L, Yan W, Song Y
Journal of cellular and molecular medicine 2021 Jun;25(12):5511-5524
Journal of cellular and molecular medicine 2021 Jun;25(12):5511-5524
Fructose-1,6-bisphosphatase aggravates oxidative stress-induced apoptosis in asthma by suppressing the Nrf2 pathway.
Hu J, Wang J, Li C, Shang Y
Journal of cellular and molecular medicine 2021 Jun;25(11):5001-5014
Journal of cellular and molecular medicine 2021 Jun;25(11):5001-5014
Oxymatrine pretreatment protects H9c2 cardiomyocytes from hypoxia/reoxygenation injury by modulating the PI3K/Akt pathway.
Zhang Z, Qin X, Wang Z, Li Y, Chen F, Chen R, Li C, Zhang W, Zhang M
Experimental and therapeutic medicine 2021 Jun;21(6):556
Experimental and therapeutic medicine 2021 Jun;21(6):556
Design, synthesis and biological evaluation of anilide (dicarboxylic acid) shikonin esters as antitumor agents through targeting PI3K/Akt/mTOR signaling pathway.
Ma Y, Yang X, Han H, Wen Z, Yang M, Zhang Y, Fu J, Wang X, Yin T, Lu G, Qi J, Lin H, Wang X, Yang Y
Bioorganic chemistry 2021 Jun;111:104872
Bioorganic chemistry 2021 Jun;111:104872
O-GlcNAc / Akt pathway regulates glucose metabolism and reduces apoptosis in liver of piglets with acute cold stress.
Liu Y, Xu B, Hu Y, Liu P, Lian S, Lv H, Yang Y, Ji H, Yang H, Liu J, Yao R, Li S
Cryobiology 2021 Jun;100:125-132
Cryobiology 2021 Jun;100:125-132
A natural product, Piperlongumine (PL), increases tumor cells sensitivity to NK cell killing.
Afolabi LO, Bi J, Chen L, Wan X
International immunopharmacology 2021 Jul;96:107658
International immunopharmacology 2021 Jul;96:107658
YAP/TEAD4-induced KIF4A contributes to the progression and worse prognosis of esophageal squamous cell carcinoma.
Li Y, Zhu X, Yang M, Wang Y, Li J, Fang J, Guo W, Ma S, Guan F
Molecular carcinogenesis 2021 Jul;60(7):440-454
Molecular carcinogenesis 2021 Jul;60(7):440-454
HORMAD1 promotes docetaxel resistance in triple negative breast cancer by enhancing DNA damage tolerance.
Zong B, Sun L, Peng Y, Wang Y, Yu Y, Lei J, Zhang Y, Guo S, Li K, Liu S
Oncology reports 2021 Jul;46(1)
Oncology reports 2021 Jul;46(1)
Dynamin 3 overexpression suppresses the proliferation, migration and invasion of cervical cancer cells.
Fa J
Oncology letters 2021 Jul;22(1):524
Oncology letters 2021 Jul;22(1):524
BACH1 is transcriptionally inhibited by TET1 in hepatocellular carcinoma in a microRNA-34a-dependent manner to regulate autophagy and inflammation.
Sun X, Zhu H, Cao R, Zhang J, Wang X
Pharmacological research 2021 Jul;169:105611
Pharmacological research 2021 Jul;169:105611
HDAC6 suppresses microRNA-199a transcription and augments HPV-positive cervical cancer progression through Wnt5a upregulation.
Shao Y, Zhu F, Zhu S, Bai L
The international journal of biochemistry & cell biology 2021 Jul;136:106000
The international journal of biochemistry & cell biology 2021 Jul;136:106000
Comparable radiation sensitivity in p53 wild-type and p53 deficient tumor cells associated with different cell death modalities.
Li P, Liu X, Zhao T, Li F, Wang Q, Zhang P, Hirayama R, Chen W, Jin X, Zheng X, Wang Z, Li Q
Cell death discovery 2021 Jul 20;7(1):184
Cell death discovery 2021 Jul 20;7(1):184
Effects and mechanism of microRNA‑218 against lung cancer.
Chen Y, Yang JL, Xue ZZ, Cai QC, Hou C, Li HJ, Zhao LX, Zhang Y, Gao CW, Cong L, Wang TZ, Chen DM, Li GS, Luo SQ, Yao Q, Yang CJ, Zhu QS, Cao CH
Molecular medicine reports 2021 Jan;23(1)
Molecular medicine reports 2021 Jan;23(1)
Antitumor effects of dioscin in A431 cells via adjusting ATM/p53-mediated cell apoptosis, DNA damage and migration.
Wang P, Wang C, Liu C
Oncology letters 2021 Jan;21(1):59
Oncology letters 2021 Jan;21(1):59
Histone deacetylase 10 exerts anti-tumor effects on cervical cancer via a novel microRNA-223/TXNIP/Wnt/β-catenin pathway.
Zhu J, Han S
IUBMB life 2021 Jan 22;
IUBMB life 2021 Jan 22;
BAIAP2L2 promotes the proliferation, migration and invasion of osteosarcoma associated with the Wnt/β-catenin pathway.
Guo H, Peng J, Hu J, Chang S, Liu H, Luo H, Chen X, Tang H, Chen Y
Journal of bone oncology 2021 Dec;31:100393
Journal of bone oncology 2021 Dec;31:100393
MET inhibition enhances PARP inhibitor efficacy in castration-resistant prostate cancer by suppressing the ATM/ATR and PI3K/AKT pathways.
Zhou S, Dai Z, Wang L, Gao X, Yang L, Wang Z, Wang Q, Liu Z
Journal of cellular and molecular medicine 2021 Dec;25(24):11157-11169
Journal of cellular and molecular medicine 2021 Dec;25(24):11157-11169
Ketoprofen and Loxoprofen Platinum(IV) Complexes Displaying Antimetastatic Activities by Inducing DNA Damage, Inflammation Suppression, and Enhanced Immune Response.
Li Z, Wang Q, Li L, Chen Y, Cui J, Liu M, Zhang N, Liu Z, Han J, Wang Z
Journal of medicinal chemistry 2021 Dec 23;64(24):17920-17935
Journal of medicinal chemistry 2021 Dec 23;64(24):17920-17935
Protective Effect of Flavonoids from a Deep-Sea-Derived Arthrinium sp. against ox-LDL-Induced Oxidative Injury through Activating the AKT/Nrf2/HO-1 Pathway in Vascular Endothelial Cells.
Hou JR, Wang YH, Zhong YN, Che TT, Hu Y, Bao J, Meng N
Marine drugs 2021 Dec 18;19(12)
Marine drugs 2021 Dec 18;19(12)
Structural analysis of Panax ginseng glycoproteins and its anti-oligoasthenozoospermia effect in vivo.
Shan M, Zhang X, Fang X, Tian J, Song L, Chen Y, Qiu Z, Zhu D, Luo H, Wang Z
International journal of biological macromolecules 2021 Dec 15;193(Pt A):778-788
International journal of biological macromolecules 2021 Dec 15;193(Pt A):778-788
Acetylcholine ameliorated hypoxia-induced oxidative stress and apoptosis in trophoblast cells via p38 MAPK/NF-κB pathway.
Wang Z, Zhao G, Zibrila AI, Li Y, Liu J, Feng W
Molecular human reproduction 2021 Aug 7;27(8)
Molecular human reproduction 2021 Aug 7;27(8)
circBTBD7 Promotes Immature Porcine Sertoli Cell Growth through Modulating miR-24-3p/MAPK7 Axis to Inactivate p38 MAPK Signaling Pathway.
Bian Q, Chen B, Weng B, Chu D, Tang X, Yan S, Yin Y, Ran M
International journal of molecular sciences 2021 Aug 30;22(17)
International journal of molecular sciences 2021 Aug 30;22(17)
Limonin induces apoptosis of HL-60 cells by inhibiting NQO1 activity.
Chen Y, Liang J, Liang X, Chen J, Wang Y, Cao J, Sun C, Ye J, Chen Q
Food science & nutrition 2021 Apr;9(4):1860-1869
Food science & nutrition 2021 Apr;9(4):1860-1869
Histone deacetylase 10 exerts antitumor effects on cervical cancer via a novel microRNA-223/TXNIP/Wnt/β-catenin pathway.
Zhu J, Han S
IUBMB life 2021 Apr;73(4):690-704
IUBMB life 2021 Apr;73(4):690-704
Heat shock protein 22 modulates NRF1/TFAM-dependent mitochondrial biogenesis and DRP1-sparked mitochondrial apoptosis through AMPK-PGC1α signaling pathway to alleviate the early brain injury of subarachnoid hemorrhage in rats.
Fan H, Ding R, Liu W, Zhang X, Li R, Wei B, Su S, Jin F, Wei C, He X, Li X, Duan C
Redox biology 2021 Apr;40:101856
Redox biology 2021 Apr;40:101856
Glaucocalyxin A induces cell cycle arrest and apoptosis via inhibiting NF-κB/p65 signaling pathway in melanoma cells.
Chen J, Zhang W, Pan C, Fan J, Zhong X, Tang S
Life sciences 2021 Apr 15;271:119185
Life sciences 2021 Apr 15;271:119185
Anticancer Activity of Tetrandrine by Inducing Apoptosis in Human Breast Cancer Cell Line MDA-MB-231 In Vivo.
Wang CH, Yang JM, Guo YB, Shen J, Pei XH
Evidence-based complementary and alternative medicine : eCAM 2020;2020:6823520
Evidence-based complementary and alternative medicine : eCAM 2020;2020:6823520
Galangin Inhibits Cholangiocarcinoma Cell Growth and Metastasis through Downregulation of MicroRNA-21 Expression.
Zou Y, Li R, Kuang D, Zuo M, Li W, Tong W, Jiang L, Zhou M, Chen Y, Gong W, Liu L, Tou F
BioMed research international 2020;2020:5846938
BioMed research international 2020;2020:5846938
Homoharringtonine Exerts an Antimyeloma Effect by Promoting Excess Parkin-Dependent Mitophagy.
Zhang Y, Huang N, Xu J, Zheng W, Cui X
Drug design, development and therapy 2020;14:4749-4763
Drug design, development and therapy 2020;14:4749-4763
Antitumor effects of aconitine in A2780 cells via estrogen receptor β‑mediated apoptosis, DNA damage and migration.
Wang X, Lin Y, Zheng Y
Molecular medicine reports 2020 Sep;22(3):2318-2328
Molecular medicine reports 2020 Sep;22(3):2318-2328
Anti‑proliferative effect of honokiol on SW620 cells through upregulating BMP7 expression via the TGF‑β1/p53 signaling pathway.
Li Q, Ma Y, Liu XL, Mu L, He BC, Wu K, Sun WJ
Oncology reports 2020 Nov;44(5):2093-2107
Oncology reports 2020 Nov;44(5):2093-2107
Synthesis and biological evaluations of N'-substituted methylene-4-(quinoline-4-amino) benzoylhydrazides as potential anti-hepatoma agents.
Li B, Zhu F, He F, Huang Q, Liu X, Wu T, Zhao T, Qiu Y, Wu Z, Xue Y, Fang M
Bioorganic chemistry 2020 Mar;96:103592
Bioorganic chemistry 2020 Mar;96:103592
Cyclovirobuxine D Exerts Anticancer Effects by Suppressing the EGFR-FAK-AKT/ERK1/2-Slug Signaling Pathway in Human Hepatocellular Carcinoma.
Zhang J, Chen Y, Lin J, Jia R, An T, Dong T, Zhang Y, Yang X
DNA and cell biology 2020 Mar;39(3):355-367
DNA and cell biology 2020 Mar;39(3):355-367
Insights into mechanisms of pranoprofen-induced apoptosis and necroptosis in human corneal stromal cells.
Lin Y, Yu M, Fan T
Toxicology letters 2020 Mar 1;320:9-18
Toxicology letters 2020 Mar 1;320:9-18
Long noncoding RNA linc00467 plays an oncogenic role in hepatocellular carcinoma by regulating the miR-18a-5p/NEDD9 axis.
Zheng Y, Nie P, Xu S
Journal of cellular biochemistry 2020 Jun;121(5-6):3135-3144
Journal of cellular biochemistry 2020 Jun;121(5-6):3135-3144
The roles of SHANK1 in the development of colon cancer.
Wang L, Lv Y, Liu G
Cell biochemistry and function 2020 Jul;38(5):669-675
Cell biochemistry and function 2020 Jul;38(5):669-675
Thermosensitive heparin-poloxamer hydrogel encapsulated bFGF and NGF to treat spinal cord injury.
Hu X, Li R, Wu Y, Li Y, Zhong X, Zhang G, Kang Y, Liu S, Xie L, Ye J, Xiao J
Journal of cellular and molecular medicine 2020 Jul;24(14):8166-8178
Journal of cellular and molecular medicine 2020 Jul;24(14):8166-8178
Protective Effects of Ischemic Postconditioning on Livers in Rats with Limb Ischemia-Reperfusion via Glycogen Synthase Kinase 3 beta (GSK-3β)/Fyn/Nuclear Receptor-Erythroid-2-Related Factor (Nrf2) Pathway.
Niu Q, Sun W, Chen Q, Long Y, Cao W, Wen S, Li A, Dong F, Shi H
Medical science monitor : international medical journal of experimental and clinical research 2020 Jul 20;26:e923049
Medical science monitor : international medical journal of experimental and clinical research 2020 Jul 20;26:e923049
Intracellular expression of arginine deiminase activates the mitochondrial apoptosis pathway by inhibiting cytosolic ferritin and inducing chromatin autophagy.
Feng Q, Bian X, Liu X, Wang Y, Zhou H, Ma X, Quan C, Yao Y, Zheng Z
BMC cancer 2020 Jul 16;20(1):665
BMC cancer 2020 Jul 16;20(1):665
Cinnamaldehyde Enhances Antimelanoma Activity through Covalently Binding ENO1 and Exhibits a Promoting Effect with Dacarbazine.
Zhang W, Gao J, Cheng C, Zhang M, Liu W, Ma X, Lei W, Hao E, Hou X, Hou Y, Bai G
Cancers 2020 Jan 29;12(2)
Cancers 2020 Jan 29;12(2)
Oxaliplatin resistance is enhanced by saracatinib via upregulation Wnt-ABCG1 signaling in hepatocellular carcinoma.
Liao X, Song G, Xu Z, Bu Y, Chang F, Jia F, Xiao X, Ren X, Zhang M, Jia Q
BMC cancer 2020 Jan 13;20(1):31
BMC cancer 2020 Jan 13;20(1):31
Human cathelicidin antimicrobial peptide suppresses proliferation, migration and invasion of oral carcinoma HSC-3 cells via a novel mechanism involving caspase-3 mediated apoptosis.
Chen X, Ji S, Si J, Zhang X, Wang X, Guo Y, Zou X
Molecular medicine reports 2020 Dec;22(6):5243-5250
Molecular medicine reports 2020 Dec;22(6):5243-5250
Long noncoding RNA HAND2-AS1 reduced the viability of hepatocellular carcinoma via targeting microRNA-300/SOCS5 axis.
Bi HQ, Li ZH, Zhang H
Hepatobiliary & pancreatic diseases international : HBPD INT 2020 Dec;19(6):567-574
Hepatobiliary & pancreatic diseases international : HBPD INT 2020 Dec;19(6):567-574
Down-regulation of long noncoding RNA LINC00472 alleviates sepsis-induced acute hepatic injury by regulating miR-373-3p/TRIM8 axis.
Li L, He Y, He XJ, Bi MR, Qi YH, Zhu WW
Experimental and molecular pathology 2020 Dec;117:104562
Experimental and molecular pathology 2020 Dec;117:104562
Acetylcholine ameliorated TNF-α-induced primary trophoblast malfunction via muscarinic receptors†.
Wang Z, Zibrila AI, Liu S, Zhao G, Li Y, Xu J, Liu D, Li C, Feng W, Liu J
Biology of reproduction 2020 Dec 1;103(6):1238-1248
Biology of reproduction 2020 Dec 1;103(6):1238-1248
METTL3 serves an oncogenic role in human ovarian cancer cells partially via the AKT signaling pathway.
Liang S, Guan H, Lin X, Li N, Geng F, Li J
Oncology letters 2020 Apr;19(4):3197-3204
Oncology letters 2020 Apr;19(4):3197-3204
Physicochemical characterization of polysaccharide from the leaf of Dendrobium officinale and effect on LPS induced damage in GES-1 cell.
Yang K, Lu T, Zhan L, Zhou C, Zhang N, Lei S, Wang Y, Yang J, Yan M, Lv G, Chen S
International journal of biological macromolecules 2020 Apr 15;149:320-330
International journal of biological macromolecules 2020 Apr 15;149:320-330
High glucose causes apoptosis of rabbit corneal epithelial cells involving activation of PERK-eIF2α-CHOP-caspase-12 signaling pathway.
Yao PP, Sheng MJ, Weng WH, Long Y, Liu H, Chen L, Lu JJ, Rong A, Li B
International journal of ophthalmology 2019;12(12):1815-1822
International journal of ophthalmology 2019;12(12):1815-1822
Emodin Induced SREBP1-Dependent and SREBP1-Independent Apoptosis in Hepatocellular Carcinoma Cells.
Yang N, Li C, Li H, Liu M, Cai X, Cao F, Feng Y, Li M, Wang X
Frontiers in pharmacology 2019;10:709
Frontiers in pharmacology 2019;10:709
Simvastatin promotes endothelial dysfunction by activating the Wnt/β‑catenin pathway under oxidative stress.
He Z, Du X, Wu Y, Hua L, Wan L, Yan N
International journal of molecular medicine 2019 Oct;44(4):1289-1298
International journal of molecular medicine 2019 Oct;44(4):1289-1298
Linc01105 acts as an oncogene in the development of neuroblastoma.
Ye M, Ma J, Liu B, Liu X, Ma D, Dong K
Oncology reports 2019 Oct;42(4):1527-1538
Oncology reports 2019 Oct;42(4):1527-1538
Anti-Inflammatory and Anti-Apoptotic Effects of Stybenpropol A on Human Umbilical Vein Endothelial Cells.
Zhang L, Wang F, Zhang Q, Liang Q, Wang S, Xian M, Wang F
International journal of molecular sciences 2019 Oct 29;20(21)
International journal of molecular sciences 2019 Oct 29;20(21)
Knockdown of long noncoding RNA DLEU1 suppresses the progression of renal cell carcinoma by downregulating the Akt pathway.
Yue G, Chen C, Bai L, Wang G, Huang Y, Wang Y, Cui H, Xiao Y
Molecular medicine reports 2019 Nov;20(5):4551-4557
Molecular medicine reports 2019 Nov;20(5):4551-4557
Regulating glycolysis, the TLR4 signal pathway and expression of RBM3 in mouse liver in response to acute cold exposure.
Shi H, Yao R, Lian S, Liu P, Liu Y, Yang YY, Yang H, Li S
Stress (Amsterdam, Netherlands) 2019 May;22(3):366-376
Stress (Amsterdam, Netherlands) 2019 May;22(3):366-376
Effects of Cold-inducible RNA-binding Protein (CIRP) on Liver Glycolysis during Acute Cold Exposure in C57BL/6 Mice.
Liu P, Yao R, Shi H, Liu Y, Lian S, Yang Y, Yang H, Li S
International journal of molecular sciences 2019 Mar 23;20(6)
International journal of molecular sciences 2019 Mar 23;20(6)
Sphingomyelin Synthase 2 Promotes Endothelial Dysfunction by Inducing Endoplasmic Reticulum Stress.
Hua L, Wu N, Zhao R, He X, Liu Q, Li X, He Z, Yu L, Yan N
International journal of molecular sciences 2019 Jun 12;20(12)
International journal of molecular sciences 2019 Jun 12;20(12)
Rho GDP dissociation inhibitor α silencing attenuates silicosis by inhibiting RhoA/Rho kinase signalling.
Wei Z, Xu H, Zhang Y, Yi X, Yang X, Chen Y, Mao N, Li S, Xu D, Li S, Zhang H, Li D, Zhang G, Zhang B, Jin F, Gao X, Cai W, Zhang L, Wang R, Yang F
Experimental cell research 2019 Jul 15;380(2):131-140
Experimental cell research 2019 Jul 15;380(2):131-140
The interaction of Atg4B and Bcl-2 plays an important role in Cd-induced crosstalk between apoptosis and autophagy through disassociation of Bcl-2-Beclin1 in A549 cells.
Li Z, Li Q, Lv W, Jiang L, Geng C, Yao X, Shi X, Liu Y, Cao J
Free radical biology & medicine 2019 Jan;130:576-591
Free radical biology & medicine 2019 Jan;130:576-591
Derlin1 functions as an oncogene in cervical cancer via AKT/mTOR signaling pathway.
Li L, Liu M, Zhang Z, Zhang W, Liu N, Sheng X, Wei P
Biological research 2019 Feb 27;52(1):8
Biological research 2019 Feb 27;52(1):8
Silencing TTK expression inhibits the proliferation and progression of prostate cancer.
Chen S, Wang J, Wang L, Peng H, Xiao L, Li C, Lin D, Yang K
Experimental cell research 2019 Dec 1;385(1):111669
Experimental cell research 2019 Dec 1;385(1):111669
Protective effects of Platycodon grandiflorus polysaccharides against apoptosis induced by carbonyl cyanide 3-chlorophenylhydrazone in 3D4/21 cells.
Wang C, Cheng G, Yang S, Li L, Zhang Y, Zhao X, Liu J
International journal of biological macromolecules 2019 Dec 1;141:1220-1227
International journal of biological macromolecules 2019 Dec 1;141:1220-1227
MicroRNA-2053 overexpression inhibits the development and progression of hepatocellular carcinoma.
Song T, Ma K, Zhao C, Yang J, Liu J
Oncology letters 2019 Aug;18(2):2043-2049
Oncology letters 2019 Aug;18(2):2043-2049
CDKL1 promotes the chemoresistance of human oral squamous cell carcinoma cells to hydroxycamptothecin.
Li K, Meng Z, Jiang L, Xia C, Xu K, Yuan D, Chen H, Zhang B, Liu S
Molecular and cellular probes 2019 Apr;44:57-62
Molecular and cellular probes 2019 Apr;44:57-62
Alkaline ceramidase 3 promotes growth of hepatocellular carcinoma cells via regulating S1P/S1PR2/PI3K/AKT signaling.
Yin Y, Xu M, Gao J, Li M
Pathology, research and practice 2018 Sep;214(9):1381-1387
Pathology, research and practice 2018 Sep;214(9):1381-1387
UNBS5162 inhibits proliferation of human melanoma cells by inducing apoptosis via the PI3K/Akt pathway.
Shi X, Yang L, Xie J, Zhao Y, Cong J, Li Z, Li H, Cheng X, Fan J
Molecular medicine reports 2018 Sep;18(3):3382-3388
Molecular medicine reports 2018 Sep;18(3):3382-3388
Effects of Acute Cold Stress on Liver O-GlcNAcylation and Glycometabolism in Mice.
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International journal of molecular sciences 2018 Sep 18;19(9)
International journal of molecular sciences 2018 Sep 18;19(9)
14-3-3ε is a nuclear matrix protein, and its altered expression and localization are associated with curcumin-induced apoptosis of MG-63 cells.
Lu K, Rui G, Liu F, Yang L, Deng X, Shi S, Li Q
Oncology letters 2018 Jan;15(1):338-346
Oncology letters 2018 Jan;15(1):338-346
A small molecule targeting glutathione activates Nrf2 and inhibits cancer cell growth through promoting Keap-1 S-glutathionylation and inducing apoptosis.
Wang L, Qu G, Gao Y, Su L, Ye Q, Jiang F, Zhao B, Miao J
RSC advances 2018 Jan 2;8(2):792-804
RSC advances 2018 Jan 2;8(2):792-804
Urea transport B gene induces melanoma B16 cell death via activation of p53 and mitochondrial apoptosis.
Liu L, Sun Y, Zhao Y, Wang Q, Guo H, Guo R, Liu Y, Fu S, Zhang L, Li Y, Meng Y
Cancer science 2018 Dec;109(12):3762-3773
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Knockdown of PAICS inhibits malignant proliferation of human breast cancer cell lines.
Meng M, Chen Y, Jia J, Li L, Yang S
Biological research 2018 Aug 10;51(1):24
Biological research 2018 Aug 10;51(1):24
Resveratrol attenuates mechanical compression-induced nucleus pulposus cell apoptosis through regulating the ERK1/2 signaling pathway in a disc organ culture.
Zhang Z, Wen F, He C, Yu J
Bioscience reports 2018 Apr 27;38(2)
Bioscience reports 2018 Apr 27;38(2)
Anti-tumor effect of evodiamine by inducing Akt-mediated apoptosis in hepatocellular carcinoma.
Yang F, Shi L, Liang T, Ji L, Zhang G, Shen Y, Zhu F, Xu L
Biochemical and biophysical research communications 2017 Mar 25;485(1):54-61
Biochemical and biophysical research communications 2017 Mar 25;485(1):54-61
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Li B, Hou D, Guo H, Zhou H, Zhang S, Xu X, Liu Q, Zhang X, Zou Y, Gong Y, Shao C
Scientific reports 2017 Mar 16;7(1):208
Scientific reports 2017 Mar 16;7(1):208
The role of the ATM/Chk/P53 pathway in mediating DNA damage in hand-foot syndrome induced by PLD.
Yang J, Qiao L, Zeng Z, Wang J, Zhu T, Wei J, Wu M, Ye S, Huang X, Ma D, Liu R, Gao Q
Toxicology letters 2017 Jan 4;265:131-139
Toxicology letters 2017 Jan 4;265:131-139
Long Non-Coding RNA BANCR Promotes Endometrial Cancer Cell Proliferation and Invasion by Regulating MMP2 and MMP1 via ERK/MAPK Signaling Pathway.
Wang D, Wang D, Wang N, Long Z, Ren X
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016;40(3-4):644-656
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016;40(3-4):644-656
A targeted proteomics approach to the quantitative analysis of ERK/Bcl-2-mediated anti-apoptosis and multi-drug resistance in breast cancer.
Yang T, Xu F, Sheng Y, Zhang W, Chen Y
Analytical and bioanalytical chemistry 2016 Oct;408(26):7491-503
Analytical and bioanalytical chemistry 2016 Oct;408(26):7491-503
Neuroprotective effect of ethyl acetate extract from gastrodia elata against transient focal cerebral ischemia in rats induced by middle cerebral artery occlusion.
Duan X, Wang W, Liu X, Yan H, Dai R, Lin Q
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2015 Dec;35(6):671-8
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2015 Dec;35(6):671-8
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Sun Y, Liu Z, Zou X, Lan Y, Sun X, Wang X, Zhao S, Jiang C, Liu H
Journal of bioenergetics and biomembranes 2015 Aug;47(4):319-29
Journal of bioenergetics and biomembranes 2015 Aug;47(4):319-29
Melatonin synergized with cyclosporine A improves cardiac allograft survival by suppressing inflammation and apoptosis.
Liu C, Hong T, Shao M, Chen Z, Wang C
Molecular medicine reports 2014 Sep;10(3):1323-8
Molecular medicine reports 2014 Sep;10(3):1323-8
Apoptosis-induced anti-tumor effect of Curcuma kwangsiensis polysaccharides against human nasopharyngeal carcinoma cells.
Zeng J, Dai P, Ren L, Song B, Chen X, Wang X, Wang J, Zhang T, Zhu W
Carbohydrate polymers 2012 Aug 1;89(4):1067-72
Carbohydrate polymers 2012 Aug 1;89(4):1067-72
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 60178-1-Ig(BCL2 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The BCL2 antibody from Proteintech is a mouse monoclonal antibody to a recombinant protein of human BCL2. This antibody recognizes human antigen. The BCL2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
