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- References [19]
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- Product number
- ABIN2846147 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 75-110), (BH3 Domain) antibody
- Antibody type
- Polyclonal
- Description
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- Reactivity
- Human
- Host
- Rabbit
- Epitope
- AA 75-110, BH3 Domain
- Antibody clone number
- RB04684
- Vial size
- 80 μL
- Storage
- Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Submitted references Ropivacaine- and bupivacaine-induced death of rabbit annulus fibrosus cells in vitro: involvement of the mitochondrial apoptotic pathway.
Retinoids induce Nur77-dependent apoptosis in mouse thymocytes.
Differential roles for Bim and Nur77 in thymocyte clonal deletion induced by ubiquitous self-antigen.
Oridonin phosphate-induced autophagy effectively enhances cell apoptosis of human breast cancer cells.
Mitochondrial damage revealed by immunoselection for ALS-linked misfolded SOD1.
An over-oxidized form of superoxide dismutase found in sporadic amyotrophic lateral sclerosis with bulbar onset shares a toxic mechanism with mutant SOD1.
Natural diterpenoid compound elevates expression of Bim protein, which interacts with antiapoptotic protein Bcl-2, converting it to proapoptotic Bax-like molecule.
Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth.
ALS-linked mutant SOD1 damages mitochondria by promoting conformational changes in Bcl-2.
The conformation change of Bcl-2 is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in SGC7901 human gastric cancer cells.
Paclitaxel directly binds to Bcl-2 and functionally mimics activity of Nur77.
Protein phosphatase 2A inactivates Bcl2's antiapoptotic function by dephosphorylation and up-regulation of Bcl2-p53 binding.
A short Nur77-derived peptide converts Bcl-2 from a protector to a killer.
Modulation of orphan nuclear receptor Nur77-mediated apoptotic pathway by acetylshikonin and analogues.
During negative selection, Nur77 family proteins translocate to mitochondria where they associate with Bcl-2 and expose its proapoptotic BH3 domain.
BCL-2 dependence and ABT-737 sensitivity in acute lymphoblastic leukemia.
Gossypol induces Bax/Bak-independent activation of apoptosis and cytochrome c release via a conformational change in Bcl-2.
High level of Bcl-2 counteracts apoptosis mediated by a live rabies virus vaccine strain and induces long-term infection.
Over-expression of Bcl-2 provides protection in septic mice by a trans effect.
Cai XY, Xia Y, Yang SH, Liu XZ, Shao ZW, Liu YL, Yang W, Xiong LM
Osteoarthritis and cartilage 2015 Oct;23(10):1763-75
Osteoarthritis and cartilage 2015 Oct;23(10):1763-75
Retinoids induce Nur77-dependent apoptosis in mouse thymocytes.
Kiss B, Tóth K, Sarang Z, Garabuczi É, Szondy Z
Biochimica et biophysica acta 2015 Mar;1853(3):660-70
Biochimica et biophysica acta 2015 Mar;1853(3):660-70
Differential roles for Bim and Nur77 in thymocyte clonal deletion induced by ubiquitous self-antigen.
Hu QN, Baldwin TA
Journal of immunology (Baltimore, Md. : 1950) 2015 Mar 15;194(6):2643-53
Journal of immunology (Baltimore, Md. : 1950) 2015 Mar 15;194(6):2643-53
Oridonin phosphate-induced autophagy effectively enhances cell apoptosis of human breast cancer cells.
Li Y, Wang Y, Wang S, Gao Y, Zhang X, Lu C
Medical oncology (Northwood, London, England) 2015 Jan;32(1):365
Medical oncology (Northwood, London, England) 2015 Jan;32(1):365
Mitochondrial damage revealed by immunoselection for ALS-linked misfolded SOD1.
Pickles S, Destroismaisons L, Peyrard SL, Cadot S, Rouleau GA, Brown RH Jr, Julien JP, Arbour N, Vande Velde C
Human molecular genetics 2013 Oct 1;22(19):3947-59
Human molecular genetics 2013 Oct 1;22(19):3947-59
An over-oxidized form of superoxide dismutase found in sporadic amyotrophic lateral sclerosis with bulbar onset shares a toxic mechanism with mutant SOD1.
Guareschi S, Cova E, Cereda C, Ceroni M, Donetti E, Bosco DA, Trotti D, Pasinelli P
Proceedings of the National Academy of Sciences of the United States of America 2012 Mar 27;109(13):5074-9
Proceedings of the National Academy of Sciences of the United States of America 2012 Mar 27;109(13):5074-9
Natural diterpenoid compound elevates expression of Bim protein, which interacts with antiapoptotic protein Bcl-2, converting it to proapoptotic Bax-like molecule.
Zhao L, He F, Liu H, Zhu Y, Tian W, Gao P, He H, Yue W, Lei X, Ni B, Wang X, Jin H, Hao X, Lin J, Chen Q
The Journal of biological chemistry 2012 Jan 6;287(2):1054-65
The Journal of biological chemistry 2012 Jan 6;287(2):1054-65
Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth.
Chiavarina B, Whitaker-Menezes D, Martinez-Outschoorn UE, Witkiewicz AK, Birbe R, Howell A, Pestell RG, Smith J, Daniel R, Sotgia F, Lisanti MP
Cancer biology & therapy 2011 Dec 15;12(12):1101-13
Cancer biology & therapy 2011 Dec 15;12(12):1101-13
ALS-linked mutant SOD1 damages mitochondria by promoting conformational changes in Bcl-2.
Pedrini S, Sau D, Guareschi S, Bogush M, Brown RH Jr, Naniche N, Kia A, Trotti D, Pasinelli P
Human molecular genetics 2010 Aug 1;19(15):2974-86
Human molecular genetics 2010 Aug 1;19(15):2974-86
The conformation change of Bcl-2 is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in SGC7901 human gastric cancer cells.
Zheng Y, Zhou M, Ye A, Li Q, Bai Y, Zhang Q
World journal of surgical oncology 2010 Apr 20;8:31
World journal of surgical oncology 2010 Apr 20;8:31
Paclitaxel directly binds to Bcl-2 and functionally mimics activity of Nur77.
Ferlini C, Cicchillitti L, Raspaglio G, Bartollino S, Cimitan S, Bertucci C, Mozzetti S, Gallo D, Persico M, Fattorusso C, Campiani G, Scambia G
Cancer research 2009 Sep 1;69(17):6906-14
Cancer research 2009 Sep 1;69(17):6906-14
Protein phosphatase 2A inactivates Bcl2's antiapoptotic function by dephosphorylation and up-regulation of Bcl2-p53 binding.
Deng X, Gao F, May WS
Blood 2009 Jan 8;113(2):422-8
Blood 2009 Jan 8;113(2):422-8
A short Nur77-derived peptide converts Bcl-2 from a protector to a killer.
Kolluri SK, Zhu X, Zhou X, Lin B, Chen Y, Sun K, Tian X, Town J, Cao X, Lin F, Zhai D, Kitada S, Luciano F, O'Donnell E, Cao Y, He F, Lin J, Reed JC, Satterthwait AC, Zhang XK
Cancer cell 2008 Oct 7;14(4):285-98
Cancer cell 2008 Oct 7;14(4):285-98
Modulation of orphan nuclear receptor Nur77-mediated apoptotic pathway by acetylshikonin and analogues.
Liu J, Zhou W, Li SS, Sun Z, Lin B, Lang YY, He JY, Cao X, Yan T, Wang L, Lu J, Han YH, Cao Y, Zhang XK, Zeng JZ
Cancer research 2008 Nov 1;68(21):8871-80
Cancer research 2008 Nov 1;68(21):8871-80
During negative selection, Nur77 family proteins translocate to mitochondria where they associate with Bcl-2 and expose its proapoptotic BH3 domain.
Thompson J, Winoto A
The Journal of experimental medicine 2008 May 12;205(5):1029-36
The Journal of experimental medicine 2008 May 12;205(5):1029-36
BCL-2 dependence and ABT-737 sensitivity in acute lymphoblastic leukemia.
Del Gaizo Moore V, Schlis KD, Sallan SE, Armstrong SA, Letai A
Blood 2008 Feb 15;111(4):2300-9
Blood 2008 Feb 15;111(4):2300-9
Gossypol induces Bax/Bak-independent activation of apoptosis and cytochrome c release via a conformational change in Bcl-2.
Lei X, Chen Y, Du G, Yu W, Wang X, Qu H, Xia B, He H, Mao J, Zong W, Liao X, Mehrpour M, Hao X, Chen Q
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006 Oct;20(12):2147-9
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006 Oct;20(12):2147-9
High level of Bcl-2 counteracts apoptosis mediated by a live rabies virus vaccine strain and induces long-term infection.
Thoulouze MI, Lafage M, Yuste VJ, Baloul L, Edelman L, Kroemer G, Israel N, Susin SA, Lafon M
Virology 2003 Sep 30;314(2):549-61
Virology 2003 Sep 30;314(2):549-61
Over-expression of Bcl-2 provides protection in septic mice by a trans effect.
Iwata A, Stevenson VM, Minard A, Tasch M, Tupper J, Lagasse E, Weissman I, Harlan JM, Winn RK
Journal of immunology (Baltimore, Md. : 1950) 2003 Sep 15;171(6):3136-41
Journal of immunology (Baltimore, Md. : 1950) 2003 Sep 15;171(6):3136-41
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- Submitted by
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Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- IHC
