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- References [8]
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- Validations
- Other assay [1]
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- Product number
- 213851 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- IFNAR2 Monoclonal Antibody (MMHAR-2)
- Antibody type
- Monoclonal
- Antigen
- Other
- Reactivity
- Human
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- MMHAR-2
- Vial size
- 50 µg
- Concentration
- 0.5 mg/mL
- Storage
- -20° C, Avoid Freeze/Thaw Cycles
Submitted references Tuberculosis-associated IFN-I induces Siglec-1 on tunneling nanotubes and favors HIV-1 spread in macrophages.
Human monocyte-derived macrophages inhibit HCMV spread independent of classical antiviral cytokines.
PARP1 depletion induces RIG-I-dependent signaling in human cancer cells.
Priming and Activation of Inflammasome by Canarypox Virus Vector ALVAC via the cGAS/IFI16-STING-Type I IFN Pathway and AIM2 Sensor.
Targeting type I interferon-mediated activation restores immune function in chronic HIV infection.
Endothelial IL-33 Expression Is Augmented by Adenoviral Activation of the DNA Damage Machinery.
Replication of Human Norovirus RNA in Mammalian Cells Reveals Lack of Interferon Response.
Immune suppression by neutrophils in HIV-1 infection: role of PD-L1/PD-1 pathway.
Dupont M, Souriant S, Balboa L, Vu Manh TP, Pingris K, Rousset S, Cougoule C, Rombouts Y, Poincloux R, Ben Neji M, Allers C, Kaushal D, Kuroda MJ, Benet S, Martinez-Picado J, Izquierdo-Useros N, Sasiain MDC, Maridonneau-Parini I, Neyrolles O, Vérollet C, Lugo-Villarino G
eLife 2020 Mar 30;9
eLife 2020 Mar 30;9
Human monocyte-derived macrophages inhibit HCMV spread independent of classical antiviral cytokines.
Becker J, Kinast V, Döring M, Lipps C, Duran V, Spanier J, Tegtmeyer PK, Wirth D, Cicin-Sain L, Alcamí A, Kalinke U
Virulence 2018;9(1):1669-1684
Virulence 2018;9(1):1669-1684
PARP1 depletion induces RIG-I-dependent signaling in human cancer cells.
Ghosh R, Roy S, Franco S
PloS one 2018;13(3):e0194611
PloS one 2018;13(3):e0194611
Priming and Activation of Inflammasome by Canarypox Virus Vector ALVAC via the cGAS/IFI16-STING-Type I IFN Pathway and AIM2 Sensor.
Liu F, Niu Q, Fan X, Liu C, Zhang J, Wei Z, Hou W, Kanneganti TD, Robb ML, Kim JH, Michael NL, Sun J, Soong L, Hu H
Journal of immunology (Baltimore, Md. : 1950) 2017 Nov 1;199(9):3293-3305
Journal of immunology (Baltimore, Md. : 1950) 2017 Nov 1;199(9):3293-3305
Targeting type I interferon-mediated activation restores immune function in chronic HIV infection.
Zhen A, Rezek V, Youn C, Lam B, Chang N, Rick J, Carrillo M, Martin H, Kasparian S, Syed P, Rice N, Brooks DG, Kitchen SG
The Journal of clinical investigation 2017 Jan 3;127(1):260-268
The Journal of clinical investigation 2017 Jan 3;127(1):260-268
Endothelial IL-33 Expression Is Augmented by Adenoviral Activation of the DNA Damage Machinery.
Stav-Noraas TE, Edelmann RJ, Poulsen LC, Sundnes O, Phung D, Küchler AM, Müller F, Kamen AA, Haraldsen G, Kaarbø M, Hol J
Journal of immunology (Baltimore, Md. : 1950) 2017 Apr 15;198(8):3318-3325
Journal of immunology (Baltimore, Md. : 1950) 2017 Apr 15;198(8):3318-3325
Replication of Human Norovirus RNA in Mammalian Cells Reveals Lack of Interferon Response.
Qu L, Murakami K, Broughman JR, Lay MK, Guix S, Tenge VR, Atmar RL, Estes MK
Journal of virology 2016 Oct 1;90(19):8906-23
Journal of virology 2016 Oct 1;90(19):8906-23
Immune suppression by neutrophils in HIV-1 infection: role of PD-L1/PD-1 pathway.
Bowers NL, Helton ES, Huijbregts RP, Goepfert PA, Heath SL, Hel Z
PLoS pathogens 2014 Mar;10(3):e1003993
PLoS pathogens 2014 Mar;10(3):e1003993
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Supportive validation
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- Invitrogen Antibodies (provider)
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- Experimental details
- THP-1 cells were infected with virus in presence of IFNAR2 antibody (Product # 213851, final concentration: 10 µg/mL). Cells were collected at 24 hours post-infection followed by RNA extraction and RT-qPCR. The mRNA level of AIM2, an interferon-inducible protein, was measured by real-time PCR. Data courtesy of Antibody Data Exchange Program.
