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- Antibody Data
- Antigen structure
- References [10]
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- Validations
- Immunocytochemistry [1]
- Immunohistochemistry [2]
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- Product number
- 19194-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#19194-1-AP, RRID:AB_2215404
- Product name
- WDR45 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated WDR45 antibody (Cat. #19194-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Lipid droplet accumulation in Wdr45-deficient cells caused by impairment of chaperone-mediated autophagic degradation of Fasn.
Cardiac glycosides restore autophagy flux in an iPSC-derived neuronal model of WDR45 deficiency.
Loss of WIPI4 in neurodegeneration causes autophagy-independent ferroptosis.
SDC1-dependent TGM2 determines radiosensitivity in glioblastoma by coordinating EPG5-mediated fusion of autophagosomes with lysosomes.
Comprehensive analysis of autophagic functions of WIPI family proteins and their implications for the pathogenesis of β-propeller associated neurodegeneration.
Mediobasal hypothalamic FKBP51 acts as a molecular switch linking autophagy to whole-body metabolism.
A neurodegeneration gene, WDR45, links impaired ferritinophagy to iron accumulation.
Iron Accumulation and Changes in Cellular Organelles in WDR45 Mutant Fibroblasts.
Autophagic defects observed in fibroblasts from a patient with β-propeller protein-associated neurodegeneration.
Early onset developmental delay and epilepsy in pediatric patients with WDR45 variants.
Xiong Q, Sun H, Wang Y, Xu Q, Zhang Y, Xu M, Zhao Z, Li P, Wu C
Lipids in health and disease 2024 Mar 28;23(1):91
Lipids in health and disease 2024 Mar 28;23(1):91
Cardiac glycosides restore autophagy flux in an iPSC-derived neuronal model of WDR45 deficiency.
Papandreou A, Singh N, Gianfrancesco L, Budinger D, Barwick K, Agrotis A, Luft C, Shao Y, Lenaerts AS, Gregory A, Jeong SY, Hogarth P, Hayflick S, Barral S, Kriston-Vizi J, Gissen P, Kurian MA, Ketteler R
bioRxiv : the preprint server for biology 2024 Jun 17;
bioRxiv : the preprint server for biology 2024 Jun 17;
Loss of WIPI4 in neurodegeneration causes autophagy-independent ferroptosis.
Zhu Y, Fujimaki M, Snape L, Lopez A, Fleming A, Rubinsztein DC
Nature cell biology 2024 Apr;26(4):542-551
Nature cell biology 2024 Apr;26(4):542-551
SDC1-dependent TGM2 determines radiosensitivity in glioblastoma by coordinating EPG5-mediated fusion of autophagosomes with lysosomes.
Zheng W, Chen Q, Liu H, Zeng L, Zhou Y, Liu X, Bai Y, Zhang J, Pan Y, Shao C
Autophagy 2023 Mar;19(3):839-857
Autophagy 2023 Mar;19(3):839-857
Comprehensive analysis of autophagic functions of WIPI family proteins and their implications for the pathogenesis of β-propeller associated neurodegeneration.
Shimizu T, Tamura N, Nishimura T, Saito C, Yamamoto H, Mizushima N
Human molecular genetics 2023 Aug 7;32(16):2623-2637
Human molecular genetics 2023 Aug 7;32(16):2623-2637
Mediobasal hypothalamic FKBP51 acts as a molecular switch linking autophagy to whole-body metabolism.
Häusl AS, Bajaj T, Brix LM, Pöhlmann ML, Hafner K, De Angelis M, Nagler J, Dethloff F, Balsevich G, Schramm KW, Giavalisco P, Chen A, Schmidt MV, Gassen NC
Science advances 2022 Mar 11;8(10):eabi4797
Science advances 2022 Mar 11;8(10):eabi4797
A neurodegeneration gene, WDR45, links impaired ferritinophagy to iron accumulation.
Aring L, Choi EK, Kopera H, Lanigan T, Iwase S, Klionsky DJ, Seo YA
Journal of neurochemistry 2022 Feb;160(3):356-375
Journal of neurochemistry 2022 Feb;160(3):356-375
Iron Accumulation and Changes in Cellular Organelles in WDR45 Mutant Fibroblasts.
Lee HE, Jung MK, Noh SG, Choi HB, Chae SH, Lee JH, Mun JY
International journal of molecular sciences 2021 Oct 28;22(21)
International journal of molecular sciences 2021 Oct 28;22(21)
Autophagic defects observed in fibroblasts from a patient with β-propeller protein-associated neurodegeneration.
Lee JH, Nam SO, Kim EK, Shin JH, Oh SH, Ryu D, Lee HE, Mun JY
American journal of medical genetics. Part A 2021 Dec;185(12):3866-3871
American journal of medical genetics. Part A 2021 Dec;185(12):3866-3871
Early onset developmental delay and epilepsy in pediatric patients with WDR45 variants.
Chen H, Qian Y, Yu S, Xiao D, Guo X, Wang Q, Hao L, Yan K, Lu Y, Dong X, Zhou W, Wu B, Zhou S, Wang H
European journal of medical genetics 2019 Feb;62(2):149-160
European journal of medical genetics 2019 Feb;62(2):149-160
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using WDR45 antibody 19194-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver using 19194-1-AP(WDR45 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human liver using 19194-1-AP(WDR45 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
