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- Antigen structure
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- Product number
- 66868-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- CD8 antibody
- Antibody type
- Monoclonal
- Description
- CD8 antibody (Cat. #66868-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 1G2B10
- Vial size
- 20ul, 150ul
Submitted references Exosomal lncRNA FENDRR Orchestrates Immune Remodelling and Ferroptosis in the Comorbidity of Lung Cancer and Type 1 Myocardial Infarction.
Downregulation of B7-H4 contributes to the synergistic effect of USP2a-targeted/anti-PD-1 combination therapy in EGFR mutant lung cancer.
LIFUS-driven engineered bacteria reprogram immunosuppressive niches via mechano-NOTCH signaling.
Diallyl Trisulfide Suppresses Tumor-Associated Macrophage M2-Like Polarization and Recruitment and Improves the Tumor Microenvironment Through Blocking CCL5/STAT3 Signaling Pathway Against Lung Cancer.
Reduced EZH2 Expression in Circulating CD8-Positive T Cells and Monocytes in Psoriasis.
USP5 inhibition stimulates immunogenic ferroptosis that enhances immunotherapy in diffuse large B-cell lymphoma.
Targeting glucocorticoid receptor to enhance immunotherapy response in triple negative breast cancer.
Lentiviral Dendritic Cell Vaccine Targeting Claudin-18.2 Elicits Potent Antitumor Immunity Against Gastric Cancer.
ZNF683(+) NK cells govern chemotherapy sensitivity in advanced HPSCC via reshaping immune microenvironment.
Aging impairs peroxisome biogenesis in human B cells.
Adiponectin attenuates atherosclerosis via macrophage polarization-mediated T Cell exhaustion by modulating the NF-κB p65/PI3K/Akt signaling pathway.
Comprehensive tumour-immune profiling reveals TREM2(+) tumour-associated macrophages facilitating lymph node metastasis in head and neck squamous cell carcinoma.
SREBF2 enhances lipid metabolism and represses anti-tumor immune responses in cervical cancer by increasing ACAT2.
Single-nucleus transcriptomics of an engineered pig model reveals microglia-T cell interactions driving Huntington's disease neurodegeneration.
Tumor-to-endothelium mitochondrial transfer licenses endothelial cells for CD8(+) T cell recognition via mitochondrial neoantigen presentation.
The expression and significance of CXCL13 and CXCR5 in the tumor microenvironment of primary central nervous system diffuse large B-cell lymphoma.
VCAN promotes the progression and recurrence of esophageal squamous cell carcinoma by remodeling the tumor microenvironment.
SpaHE-Infil: A spatial heterogeneity framework for decoding TME infiltration from H&E-stained slides.
Oncolytic adenovirus H101 enhances the anti-tumor effects of PD-1 blockade via CD47 downregulation in tumor cells.
Ultrasound-Targeted Nanobubbles Codelivering NKP-1339 and miR-142-5p for Synergistic Mitochondrial Immunogenic Cell Death and PD-L1 Inhibition in Cancer Therapy.
Mannose Inhibits NSCLC Growth and Inflammatory Microenvironment by Regulating Gut Microbiota and Targeting OGT/hnRNP R/JUN/IL-8 Axis.
Lung Cancer Cell-intrinsic Asparagine Synthetase Potentiates Anti-Tumor Immunity via Modulating Immunogenicity and Facilitating Immune Remodeling in Metastatic Tumor-draining Lymph Nodes.
Single-cell Profiling of Intrahepatic Immune Cells Reveals an Expansion of Tissue-resident Cytotoxic CD4(+) T Lymphocyte Subset Associated With Pathogenesis of Alcoholic-associated Liver Diseases.
CD82-associated exhausted CD8(+) T cells define prognosis and immunotherapy resistance in colon cancer.
Targeting PDPN enhances antitumor T-cell activity by disrupting β-catenin-mediated PD-L1 expression in melanoma.
Single-cell and bulk transcriptomics reveal a CD8(+) T-cell gene signature predicting prognosis in diffuse large B-cell lymphoma.
Characteristics of tertiary lymphoid structures in prostate cancer and the impact of neoadjuvant therapy on their formation and maturation.
Radiomic features and tumor immune microenvironment associated with anaplastic lymphoma kinase-rearranged lung adenocarcinoma and their prognostic value.
The key role of DLX6 in nasopharyngeal carcinoma: metastasis, angiogenesis and tumor immune mechanism.
NALCN expression is down-regulated and associated with immune infiltration in gastric cancer.
Itraconazole inhibits the Wnt/β-catenin signaling pathway to induce tumor-associated macrophages polarization to enhance the efficacy of immunotherapy in endometrial cancer.
Pan-Cancer Analysis of the Prognostic and Immunotherapeutic Value of PDGFB.
Single-cell analysis reveals XCL1+ CD8+ T cells as a therapeutic target in hepatocellular carcinoma.
Single-cell multi-omic and spatial profiling of esophageal squamous cell carcinoma reveals the immunosuppressive role of GPR116(+) pericytes in cancer metastasis.
Ferritinophagy Is Involved in the Advanced Glycation End Products-Induced Ferroptosis of Vascular Endothelial Cells in Diabetes Mellitus.
Loss of Skeletal Muscle Mass Is Associated With Reduced Cytotoxic T Cell Abundance and Poor Survival in Advanced Lung Cancer.
Tumor-draining lymph nodes respond to immune checkpoint inhibition and orchestrate tumor immune remodeling.
LZTR1 regulates epithelial MHC-I expression via NF-κB1 to modulate CD8(+) T cells activation.
Iron overload-induced ferroptosis in CD8(+) T cells leads to functional abnormalities that promote endometriosis progression.
Epigenetic suppression of Nrf2-Slc40a1 axis induces ferroptosis and enhances immunotherapy in pancreatic cancer.
ACOX2 destabilizes the MRE11-RAD50-NBS1 complex and boosts anticancer immunity via the cGAS-STING pathway in clear cell renal cell carcinoma.
Integrating necroptosis and immune landscapes: a multi-omics-derived NecropImmScore stratifies prognosis and therapy in ovarian cancer.
FASN inhibits ferroptosis in breast cancer via USP5 palmitoylation-dependent regulation of GPX4 deubiquitination.
AARS1 Implicates Malignancy and Immune Infiltration in Head and Neck Squamous Cell Carcinoma, Serving as a Prognostic Predictor.
NMRK2 leads to the depletion of CD8(+)T cells by mediating the enhancement of NAD(+)-SIRT1-CD38 axis in PRCC-TFE3 rRCC.
Integrated single-cell, spatial, and bulk transcriptomics reveal a chromatin regulator-TME prognostic framework guiding precision therapy in cervical cancer.
Blocking CCR1(+) macrophages overcomes resistance to immune checkpoint inhibitors in melanoma.
Co-targeting CDK4/6 enhances anti-cancer activity and alleviates immune-related adverse events of anti-PD-1 antibody for breast cancer.
Planar conjugate donor engineering enhanced photodynamic immunogenic cell death stimulator for efficient Triple-Negative breast cancer immunotherapy.
A matrix stiffness gene signature identifies SLC20A1 as a novel mechano-immunological checkpoint enabling synergistic immunotherapy in pancreatic ductal adenocarcinoma.
Cholesterol biosynthesis induced by radiotherapy inhibits cGAS-STING activation and contributes to colorectal cancer treatment resistance.
Ginseng polysaccharides ameliorate colorectal tumorigenesis through Lachnospiraceae-mediated immune modulation.
Identification of the "Collagen-Macrophage" sub-category of patients with colorectal cancer as an extension of the CMS4 subtype with THBS2 as a therapeutic target.
KIF26B promotes bladder cancer progression via activating Wnt/β-catenin signaling in a TRAF2-dependent pathway.
High-Sensitivity PD-L1 Staining Using Clone 73-10 Antibody and Spatial Transcriptomics for Precise Expression Analysis in Non-Tumorous, Intraepithelial Neoplasia, and Squamous Cell Carcinoma of Head and Neck.
Neoadjuvant with low-dose radiotherapy, tislelizumab, albumin-bound paclitaxel, and cisplatin for resectable locally advanced head and neck squamous cell carcinoma: phase II single-arm trial.
Nerve infiltration of bladder cancer predicts response to immunotherapy.
Radiotherapy-resistant prostate cancer cells escape immune checkpoint blockade through the senescence-related ataxia telangiectasia and Rad3-related protein.
GLP1 alleviates oleic acid-propelled lipocalin-2 generation by tumor-infiltrating CD8(+) T cells to reduce polymorphonuclear MDSC recruitment and enhances viral immunotherapy in pancreatic cancer.
Cryo-trojan mesenchymal stem cells as non-living tumor-homing supercarriers for enhanced drug delivery and immune activation in prostate cancer.
Spatial determinants of antibody-drug conjugate SHR-A1811 efficacy in neoadjuvant treatment for HER2-positive breast cancer.
LMNB2-mediated high PD-L1 transcription triggers the immune escape of hepatocellular carcinoma.
Spatial Transcriptome Analysis of B7-H4 in Head and Neck Squamous Cell Carcinoma: A Novel Therapeutic Target for Anti-Immune Checkpoint Inhibitors.
HIC1 suppresses Tumor Progression and Enhances CD8(+) T Cells Infiltration Through Promoting GSDMD-induced Pyroptosis in Gastric Cancer.
MIAT promotes tumor-infiltrating CD8(+) T-cell exhaustion and malignant progression of renal cell carcinoma via activating JAK3/STAT3 pathway.
Glutamine binds HSC70 to transduce signals inhibiting IFN-β-mediated immunogenic cell death.
Machine learning-based integration develops a hypoxia-derived signature for improving outcomes in glioma.
Histone deacetylases 10 as a prognostic biomarker correlates with tumor microenvironment and therapy response in colorectal cancer.
Molecular mechanism differences between nanoplastics and microplastics in colon toxicity: nanoplastics induce ferroptosis-mediated immunogenic cell death, while microplastics cause cell metabolic reprogramming.
TMOD3 accelerated resistance to immunotherapy in KRAS-mutated pancreatic cancer through promoting autophagy-dependent degradation of ASCL4.
Single-cell transcriptomic analysis of the senescent microenvironment in bone metastasis.
B7-H3 and CD39 Co-Localization in Gastric Cancer: A Potential Prognostic Biomarker and Potential Dual-Target for Immunotherapy.
Discovery of Potent and Selective CDK4/6 Inhibitors for the Treatment of Chemotherapy-Induced Myelosuppression.
Identifying effective immune biomarkers in alopecia areata diagnosis based on machine learning methods.
Itaconate transporter SLC13A3 confers immunotherapy resistance via alkylation-mediated stabilization of PD-L1.
VPS25 Promotes an Immunosuppressive Microenvironment in Head and Neck Squamous Cell Carcinoma.
ANLN promotes head and neck squamous cell carcinoma progression by upregulating PD-L1 via the ERK-MAPK pathway.
Bispecific antibody simultaneously targeting AGR2 and PD1 mediates cytotoxic T-cell-induced antitumor response in AGR2-dependent manner and inhibits AGR2-induced PDL1 upregulation.
Yin Yang 1 Promotes Antiprogrammed Cell Death-1 Resistance in Hepatocellular Carcinoma through Polypeptide N-Acetylgalactosaminyltransferase 16-Mediated Glycosylation of Programmed Death Ligand-1.
YBX1 is required for maintaining PD-L1 expression in intrahepatic cholangiocarcinoma by regulating STAT1 stability in an m5C-dependent manner.
FOXO1-driven metabolic reprogramming of hematomal CD8(+) T cells drives the expansion of perihematomal edema following intracerebral hemorrhage.
Resveratrol amplifies the anti-tumor effect of α-PD-1 by altering the intestinal microbiome and PGD2 content.
Mature tertiary lymphoid structures support B cell-mediated antitumour immunity and are disrupted by neoadjuvant therapy in rectal cancer: a multicentre, retrospective study.
Spatial Transcriptomics and snRNA-seq Expose CAF Niches Orchestrating Dual Stromal-Immune Barriers in Hepatocellular Carcinoma.
KIAA1429 impairs anti-tumor immunity via regulation of PD-L1 and CD8(+) T cells in colorectal cancer.
Metformin reshapes the tumor microenvironment and enhances prognosis in invasive pancreatic ductal adenocarcinoma with diabetes mellitus.
OX40L and IL-2 combination strategy for gastric cancer immunotherapy.
Histone deacetylase HDAC7 restricts CD8 + T cell tumor infiltration and limits immunotherapy sensitivity in bladder cancer: reversal by pinocembrin.
Screening and identification Hub genes associated with immune cell infiltration and critical biomarkers in osteosarcoma.
Immunogenic cuproptosis in cancer immunotherapy via an in situ cuproptosis-inducing system.
A novel FTO-targeting nanodrug induces disulfidptosis and ameliorates the suppressive tumor immune environment to treat uveal melanoma.
C-Reactive Protein to Lymphocyte Ratio (CLR) and Lactate Dehydrogenase to Albumin Ratio (LAR) as Prognostic Biomarkers in Acral Melanoma: Association With Tertiary Lymphoid Structures and Immune Cell Infiltration.
Biomineralized Albumin-Macrocyclic Conjugates for Synergistic Metal Ion-Based Combination Therapy in Cancer Treatment.
Spautin-1 inhibits the growth of diffuse large B-cell lymphoma by inducing mitochondrial damage-mediated PANoptosis and anti-tumor immunity.
CAD hijacks STING to impair antitumor immunity and radiotherapy efficacy of colorectal cancer.
Proteomics and single cell profiling identify keratin driven preexisting immunity influences lung squamous carcinoma neoadjuvant therapy.
Pseudogene pair-based prognostic model reveals LAT as a biomarker of immune response in head and neck squamous cell carcinoma.
Integrated multi-omics reveal lactate metabolism-related gene signatures and PYGL in predicting HNSCC prognosis and immunotherapy efficacy.
GPX2 inhibition enhances antitumor efficacy of lenvatinib via promoting immunogenic cell death in hepatocellular carcinoma.
Proteogenomic characterization of non-functional pancreatic neuroendocrine tumors unravels clinically relevant subgroups.
Reduced Abundance of Phocaeicola in Mucosa-associated Microbiota Is Associated with Distal Colorectal Cancer Metastases Possibly through an Altered Local Immune Environment.
SPOP expression is associated with tumor-infiltrating lymphocytes in pancreatic cancer.
Coactosin-Like Protein 1 (COTL1) Could Be an Immunological and Prognostic Biomarker: From Pan-Cancer Analysis to Low-Grade Glioma Validation.
The development of anti-PD-1 antibody-induced spinal cord injury in bone marrow transplant C57BL/6 Rag1(-/-) mouse model.
The cancer-associated fibroblasts interact with malignant T cells in mycosis fungoides and promote the disease progression.
Neoadjuvant immunochemotherapy improves clinical outcomes of patients with esophageal cancer by mediating anti-tumor immunity of CD8+ T (Tc1) and CD16+ NK cells.
Platinum-based neoadjuvant chemotherapy upregulates STING/IFN pathway expression and promotes TILs infiltration in NSCLC.
Serotonylation in tumor-associated fibroblasts contributes to the tumor-promoting roles of serotonin in colorectal cancer.
Intratumoral microbiota as a novel prognostic indicator in bladder cancer.
Activation of Wnt/β-catenin signaling promotes immune evasion via the β-catenin/IKZF1/CCL5 axis in hepatocellular carcinoma.
Exploring the impact of PDGFD in osteosarcoma metastasis through single-cell sequencing analysis.
ZG16 enhances the maturation of dendritic cells via induction of CD40 and contributes to the antitumor immunity in pancreatic cancer.
FAT10 induces immune suppression by upregulating PD-L1 expression in hepatocellular carcinoma.
snRNA-seq of adipose tissues reveals the potential cellular and molecular mechanisms of cold and disease resistance in Mongolian cattle.
Clinical-proteomic classification and precision treatment strategy of chordoma.
Local TSH/TSHR signaling promotes CD8(+) T cell exhaustion and immune evasion in colorectal carcinoma.
Crosstalk between GBP2 and M2 macrophage promotes the ccRCC progression.
Tumor microenvironment remodeling after neoadjuvant chemoradiotherapy in local advanced rectal cancer revealed by single-cell RNA sequencing.
Integrative analysis of the cuproptosis-related gene ATP7B in the prognosis and immune infiltration of IDH1 wild-type glioma.
GGT5: a potential immunotherapy response inhibitor in gastric cancer by modulating GSH metabolism and sustaining memory CD8+ T cell infiltration.
NDRG1 overcomes resistance to immunotherapy of pancreatic ductal adenocarcinoma through inhibiting ATG9A-dependent degradation of MHC-1.
Targeting autophagy overcomes cancer-intrinsic resistance to CAR-T immunotherapy in B-cell malignancies.
Pirin Inhibits FAS-Mediated Apoptosis to Support Colorectal Cancer Survival.
Modified Biejia Jianwan decoction restrains PD-L1-mediated immune evasion through the HIF-1α/STAT3/NF-κB signaling pathway.
WTAP regulates the production of reactive oxygen species, promotes malignant progression, and is closely related to the tumor microenvironment in glioblastoma.
The construction of modular universal chimeric antigen receptor T (MU-CAR-T) cells by covalent linkage of allogeneic T cells and various antibody fragments.
Pan-Cancer Single-Cell and Spatial-Resolved Profiling Reveals the Immunosuppressive Role of APOE+ Macrophages in Immune Checkpoint Inhibitor Therapy.
GSK0660 enhances antitumor immunotherapy by reducing PD-L1 expression.
Increase in GPIHBP1 expression in advanced stage colorectal cancer indicates poor immune surveillance.
Memory/Active T-Cell Activation Is Associated with Immunotherapeutic Response in Fumarate Hydratase-Deficient Renal Cell Carcinoma.
Distinctive multicellular immunosuppressive hubs confer different intervention strategies for left- and right-sided colon cancers.
Rosmarinic acid activates the Ras/Raf/MEK/ERK signaling pathway to regulate CD8+ T cells and autophagy to clear Chlamydia trachomatis in reproductive tract-infected mice.
Anti-VEGFR2-Interferon α Promotes the Infiltration of CD8+ T Cells in Colorectal Cancer by Upregulating the Expression of CCL5.
Effect and mechanism of T lymphocytes on human induced pluripotent stem cell-derived cardiomyocytes via Proteomics.
Systematic pan-cancer analysis insights into ICAM1 as an immunological and prognostic biomarker.
Transdermal delivery of Fn14 siRNA using a novel composite ionic liquid for treatment of psoriasis-like skin lesions.
Gut microbiota modulate CD8(+) T cell immunity in gastric cancer through Butyrate/GPR109A/HOPX.
Pumilio1 regulates NPM3/NPM1 axis to promote PD-L1-mediated immune escape in gastric cancer.
UPP1 promotes lung adenocarcinoma progression through the induction of an immunosuppressive microenvironment.
Blockade of C5a receptor unleashes tumor-associated macrophage antitumor response and enhances CXCL9-dependent CD8(+) T cell activity.
PTPRZ1 dephosphorylates and stabilizes RNF26 to reduce the efficacy of TKIs and PD-1 blockade in ccRCC.
Crosstalk between cancer-associated fibroblasts and non-neuroendocrine tumor cells in small cell lung cancer involves in glycolysis and antigen-presenting features.
Nicotinamide metabolism face-off between macrophages and fibroblasts manipulates the microenvironment in gastric cancer.
Identification and Characterization of a Novel B Cell Epitope of ASFV Virulence Protein B125R Monoclonal Antibody.
Gasdermin-E-mediated pyroptosis drives immune checkpoint inhibitor-associated myocarditis via cGAS-STING activation.
ENG is a Biomarker of Prognosis and Angiogenesis in Liver Cancer, and Promotes the Differentiation of Tumor Cells into Vascular ECs.
Immunomodulation in Endometriosis: Investigating the interrelationship between VISTA expression and Escherichia.Shigella-Associated metabolites.
The prognostic value of CD8(+) CTLs, CD163(+) TAMs, and PDL1 expression in the tumor microenvironment of primary central nervous system lymphoma.
Immune characteristics associated with lymph node metastasis in early-stage NSCLC.
Tumor-activated IL-2 mRNA delivered by lipid nanoparticles for cancer immunotherapy.
Metformin Alters Tumor Immune Microenvironment, Improving the Outcomes of Breast Cancer Patients With Type 2 Diabetes Mellitus.
Mn-Anti-CTLA4-CREKA-Sericin Nanotheragnostics for Enhanced Magnetic Resonance Imaging and Tumor Immunotherapy.
Glycyrrhetinic acid inhibits non-small cell lung cancer via promotion of Prdx6- and caspase-3-mediated mitochondrial apoptosis.
Hippo-signaling-controlled MHC class I antigen processing and presentation pathway potentiates antitumor immunity.
Diaphorobacter nitroreducens synergize with oxaliplatin to reduce tumor burden in mice with lung adenocarcinoma.
Scutellarin activates IDH1 to exert antitumor effects in hepatocellular carcinoma progression.
ISG15 is a potential therapeutic target for osteosarcoma: a comprehensive analysis based on bioinformatics and in vitro experiments.
Tumor-secreted lactate contributes to an immunosuppressive microenvironment and affects CD8 T-cell infiltration in glioblastoma.
FANCI serve as a prognostic biomarker correlated with immune infiltrates in skin cutaneous melanoma.
A novel prognostic signatures based on metastasis- and immune-related gene pairs for colorectal cancer.
PD-L1 and tumor-infiltrating CD8(+) lymphocytes are correlated with clinical characteristics in pediatric and adolescent pituitary adenomas.
LRPPRC facilitates tumor progression and immune evasion through upregulation of m(6)A modification of PD-L1 mRNA in hepatocellular carcinoma.
Protocadherin-1 serves as a prognostic biomarker and promotes pancreatic cancer progression by suppressing CD8(+) T cell infiltration through CCL5-CCR5 axis.
Establishment and validation of an immune infiltration predictive model for ovarian cancer.
Single-cell and bulk sequencing analyses reveal the immune suppressive role of PTPN6 in glioblastoma.
GPX3 is a key cholesterol-related gene associated with prognosis and tumor-infiltrating T cells in colorectal cancer.
Ki67-targeted oncolytic adenovirus expressing IL-15 improves intratumoral T cell infiltration and PD-L1 expression in glioblastoma.
METTL3 inhibition induced by M2 macrophage-derived extracellular vesicles drives anti-PD-1 therapy resistance via M6A-CD70-mediated immune suppression in thyroid cancer.
Targeting TNFAIP2 induces immunogenic cell death and sensitizes glioblastoma multiforme to anti-PD-1 therapy.
A Booster for Radiofrequency Ablation: Advanced Adjuvant Therapy via In Situ Nanovaccine Synergized with Anti-programmed Death Ligand 1 Immunotherapy for Systemically Constraining Hepatocellular Carcinoma.
Deubiquitinase inhibitor PR-619 potentiates colon cancer immunotherapy by inducing ferroptosis.
Mesothelin-targeted CAR-T therapy combined with irinotecan for the treatment of solid cancer.
Engineering high-affinity dual targeting cellular nanovesicles for optimised cancer immunotherapy.
Low-dose radiotherapy combined with dual PD-L1 and VEGFA blockade elicits antitumor response in hepatocellular carcinoma mediated by activated intratumoral CD8(+) exhausted-like T cells.
TWEAK and Fn14 are overexpressed in immune-mediated necrotizing myopathy: implications for muscle damage and repair.
FAM171B stabilizes vimentin and enhances CCL2-mediated TAM infiltration to promote bladder cancer progression.
Combination of novel oncolytic herpesvirus with paclitaxel as an efficient strategy for breast cancer therapy.
Exploration of (68)Ga-labelled prostate-specific membrane antigen-11 PET/CT parameters for identifying PBRM1 status in primary clear cell renal cell carcinoma.
Exosomal PD‑L1 promotes the formation of an immunosuppressive microenvironment in gastric diffuse large B‑cell lymphoma.
High baseline tumor burden-associated macrophages promote an immunosuppressive microenvironment and reduce the efficacy of immune checkpoint inhibitors through the IGFBP2-STAT3-PD-L1 pathway.
Prognostic value of CD8-to-EGFR ratio in salivary microvesicles of patients with oral squamous cell carcinoma.
GBP2 promotes clear cell renal cell carcinoma progression through immune infiltration and regulation of PD‑L1 expression via STAT1 signaling.
Oncogenic epidermal growth factor receptor signal-induced histone deacetylation suppresses chemokine gene expression in human lung adenocarcinoma.
Anti-signal recognition particle positive necrotizing myopathy-sjogren's syndrome overlap syndrome: a descriptive study on clinical and myopathology features.
PYCR1 promotes the malignant progression of lung cancer through the JAK-STAT3 signaling pathway via PRODH-dependent glutamine synthesize.
An integrated bioinformatic investigation of focal adhesion-related genes in glioma followed by preliminary validation of COL1A2 in tumorigenesis.
Optogenetic engineered umbilical cord MSC-derived exosomes for remodeling of the immune microenvironment in diabetic wounds and the promotion of tissue repair.
STAT4, a potential predictor of prognosis, promotes CD8 T‑cell infiltration in ovarian serous carcinoma by inducing CCL5 secretion.
An inflammation-associated ferroptosis signature optimizes the diagnosis, prognosis evaluation and immunotherapy options in hepatocellular carcinoma.
Inhibition of FGFR3 upregulates MHC-I and PD-L1 via TLR3/NF-kB pathway in muscle-invasive bladder cancer.
Intra-tumoral infiltration of adipocyte facilitates the activation of antitumor immune response in pancreatic ductal adenocarcinoma.
Virulence factors and mechanisms of paediatric pneumonia caused by Enterococcus faecalis.
Inhibition of Checkpoint Kinase 1 (CHK1) Upregulates Interferon Regulatory Factor 1 (IRF1) to Promote Apoptosis and Activate Anti-Tumor Immunity via MICA in Hepatocellular Carcinoma (HCC).
Expression of glucose transporter-1 in follicular lymphoma affected tumor-infiltrating immunocytes and was related to progression of disease within 24 months.
The PD-L1 Expression and Tumor-Infiltrating Immune Cells Predict an Unfavorable Prognosis in Pancreatic Ductal Adenocarcinoma and Adenosquamous Carcinoma.
HNRNPL induced circFAM13B increased bladder cancer immunotherapy sensitivity via inhibiting glycolysis through IGF2BP1/PKM2 pathway.
HRS Regulates Small Extracellular Vesicle PD-L1 Secretion and Is Associated with Anti-PD-1 Treatment Efficacy.
Apoptotic tumor cell-derived microparticles loading Napabucasin inhibit CSCs and synergistic immune therapy.
Proteomic and single-cell landscape reveals novel pathogenic mechanisms of HBV-infected intrahepatic cholangiocarcinoma.
Behind the Indolent Facade: Uncovering the Molecular Features and Malignancy Potential in Lung Minimally Invasive Adenocarcinoma by Single-Cell Transcriptomics.
Metformin may improve the outcome of patients with colorectal cancer and type 2 diabetes mellitus partly through effects on neutrophil extracellular traps.
Single-cell transcriptome sequencing of B-cell heterogeneity and tertiary lymphoid structure predicts breast cancer prognosis and neoadjuvant therapy efficacy.
PPARγ agonist inhibits c-Myc-mediated colorectal cancer tumor immune escape.
Zerumbone attenuates the excessive proliferation of keratinocytes in psoriasis mice through regulating NLRP3/NF-κB pathway.
Single cell transcriptomic analyses implicate an immunosuppressive tumor microenvironment in pancreatic cancer liver metastasis.
Single-cell dissection of cervical cancer reveals key subsets of the tumor immune microenvironment.
CT-based radiomics signature to predict CD8+ tumor infiltrating lymphocytes in non-small-cell lung cancer.
Regulation of CD8(+) T cells infiltration and immunotherapy by circMGA/HNRNPL complex in bladder cancer.
MAX transcriptionally enhances PD-L1 to inhibit CD8+ T cell-mediated killing of lung adenocarcinoma cells.
Characterization of myeloid signature genes for predicting prognosis and immune landscape in Ewing sarcoma.
Self-Assembly Catalase Nanocomplex Conveyed by Bacterial Vesicles for Oxygenated Photodynamic Therapy and Tumor Immunotherapy.
CLEC1B is a Promising Prognostic Biomarker and Correlated with Immune Infiltration in Hepatocellular Carcinoma.
A Comparison for Type 2 Cytokines and Lesional Inflammatory Infiltrations in Bullous Pemphigoid and Atopic Dermatitis.
Identification of a novel immune gene panel in tongue squamous cell carcinoma.
Single-cell sequencing reveals effects of chemotherapy on the immune landscape and TCR/BCR clonal expansion in a relapsed ovarian cancer patient.
Identification of ST3GAL5 as a prognostic biomarker correlating with CD8(+) T cell exhaustion in clear cell renal cell carcinoma.
CEP192 is a novel prognostic marker and correlates with the immune microenvironment in hepatocellular carcinoma.
A Study on the Radiosensitivity of Radiation-Induced Lung Injury at the Acute Phase Based on Single-Cell Transcriptomics.
Single-cell RNA sequencing reveals distinct immunology profiles in human keloid.
Identify the immune characteristics and immunotherapy value of CD93 in the pan-cancer based on the public data sets.
Transmembrane Protein 170B is a Prognostic Biomarker and Associated With Immune Infiltrates in Pancreatic Adenocarcinoma.
A Pan-Cancer Analysis Reveals CLEC5A as a Biomarker for Cancer Immunity and Prognosis.
A novel ganglioside-related risk signature can reveal the distinct immune landscape of neuroblastoma and predict the immunotherapeutic response.
Identification and experimental validation of a tumor-infiltrating lymphocytes-related long noncoding RNA signature for prognosis of clear cell renal cell carcinoma.
A pan-cancer and single-cell sequencing analysis of CD161, a promising onco-immunological biomarker in tumor microenvironment and immunotherapy.
A specific immune signature for predicting the prognosis of glioma patients with IDH1-mutation and guiding immune checkpoint blockade therapy.
Machine learning-based identification of tumor-infiltrating immune cell-associated lncRNAs for improving outcomes and immunotherapy responses in patients with low-grade glioma.
Label-free LC-MS/MS proteomics analyses reveal CLIC1 as a predictive biomarker for bladder cancer staging and prognosis.
Screening of an individualized treatment strategy for an advanced gallbladder cancer using patient-derived tumor xenograft and organoid models.
Oncolytic adenovirus with MUC16-BiTE shows enhanced antitumor immune response by reversing the tumor microenvironment in PDX model of ovarian cancer.
Identify the Prognostic and Immune Profile of VSIR in the Tumor Microenvironment: A Pan-Cancer Analysis.
Immunohistochemical analysis of PD-L1 and tumor-infiltrating immune cells expression in the tumor microenvironment of primary signet ring cell carcinoma of the prostate.
Sphingosine kinase 1 promotes tumor immune evasion by regulating the MTA3-PD-L1 axis.
miR-126 downregulates CXCL12 expression in intestinal epithelial cells to suppress the recruitment and function of macrophages and tumorigenesis in a murine model of colitis-associated colorectal cancer.
Tannins in Terminalia bellirica inhibits hepatocellular carcinoma growth via re-educating tumor-associated macrophages and restoring CD8(+)T cell function.
An improved cell line-derived xenograft humanized mouse model for evaluation of PD-1/PD-L1 blocker BMS202-induced immune responses in colorectal cancer.
Si-Wu-Tang ameliorates bile duct ligation-induced liver fibrosis via modulating immune environment.
Machine learning-based tumor-infiltrating immune cell-associated lncRNAs for predicting prognosis and immunotherapy response in patients with glioblastoma.
Identification of CD73 as a Novel Biomarker Encompassing the Tumor Microenvironment, Prognosis, and Therapeutic Responses in Various Cancers.
Programmed death ligand 1 and tumor-infiltrating CD8(+) T lymphocytes are associated with the clinical features in meningioma.
LRRC8A Is a Promising Prognostic Biomarker and Therapeutic Target for Pancreatic Adenocarcinoma.
CD4(+) T cells are required to improve the efficacy of CIK therapy in non-small cell lung cancer.
The Immunological Contribution of a Novel Metabolism-Related Signature to the Prognosis and Anti-Tumor Immunity in Cervical Cancer.
Single-cell transcriptomics links malignant T cells to the tumor immune landscape in cutaneous T cell lymphoma.
Polymeric indoximod based prodrug nanoparticles with doxorubicin entrapment for inducing immunogenic cell death and improving the immunotherapy of breast cancer.
Photosynthetic microorganisms coupled photodynamic therapy for enhanced antitumor immune effect.
The impact of neoadjuvant chemotherapy on the tumor microenvironment in advanced high-grade serous carcinoma.
CMTM6: increased circulating level and up-regulated expression in labial salivary glands in patients with primary Sjogren's syndrome.
Remodeling Chondroitin-6-Sulfate-Mediated Immune Exclusion Enhances Anti-PD-1 Response in Colorectal Cancer with Microsatellite Stability.
Salivary non-apoptotic tumoral microvesicles: A potential progressive marker in oral cancer patients.
Interleukin-10 induces expression of CD39 on CD8+T cells to potentiate anti-PD1 efficacy in EGFR-mutated non-small cell lung cancer.
SPI1 is a prognostic biomarker of immune infiltration and immunotherapy efficacy in clear cell renal cell carcinoma.
Association of MARCH7 with tumor progression and T-cell infiltration in esophageal cancer.
Neuropilin-1 is a valuable biomarker for predicting response of advanced non-small cell lung cancer patients to hypofractionated radiotherapy and PD-1 blockade.
Downregulation of PD-L1 and HLA-I in non-small cell lung cancer with ALK fusion.
SIGLEC15 amplifies immunosuppressive properties of tumor-associated macrophages in pancreatic cancer.
Paraspeckle Promotes Hepatocellular Carcinoma Immune Escape by Sequestering IFNGR1 mRNA.
ACSL4 Expression Is Associated With CD8+ T Cell Infiltration and Immune Response in Bladder Cancer.
A Novel Strategy Conjugating PD-L1 Polypeptide With Doxorubicin Alleviates Chemotherapeutic Resistance and Enhances Immune Response in Colon Cancer.
Clinical Relevance and Prognostic Value of the Neuronal Protein Neuroligin 2 in Breast Cancer.
Development of bispecific anti-c-Met/PD-1 diabodies for the treatment of solid tumors and the effect of c-Met binding affinity on efficacy.
Injectable shear-thinning polylysine hydrogels for localized immunotherapy of gastric cancer through repolarization of tumor-associated macrophages.
Hyperbaric oxygen treatment on keloid tumor immune gene expression.
Cancer-cell-biomimetic Upconversion nanoparticles combining chemo-photodynamic therapy and CD73 blockade for metastatic triple-negative breast cancer.
A novel mechanism of lung cancer inhibition by methionine enkephalin through remodeling the immune status of the tumor microenvironment.
CMTM6 expression in M2 macrophages is a potential predictor of PD-1/PD-L1 inhibitor response in colorectal cancer.
Dipeptidyl Peptidase (DPP)-4 Inhibitor Impairs the Outcomes of Patients with Type 2 Diabetes Mellitus After Curative Resection for Colorectal Cancer.
A multi-effective and long-acting immunotherapy through one single hydrogel based injection.
The impact of tobacco exposure on tumor microenvironment and prognosis in lung adenocarcinoma by integrative analysis of multi-omics data.
Tailoring Chemoimmunostimulant Bioscaffolds for Inhibiting Tumor Growth and Metastasis after Incomplete Microwave Ablation.
FABP4 deactivates NF-κB-IL1α pathway by ubiquitinating ATPB in tumor-associated macrophages and promotes neuroblastoma progression.
CD137 agonist induces gastric cancer cell apoptosis by enhancing the functions of CD8(+) T cells via NF-κB signaling.
Role of GLUT-1 in the Upregulation of PD-L1 Expression After Radiotherapy and Association of PD-L1 with Favourable Overall Survival in Hypopharyngeal Cancer.
Whole-Exome Sequencing Reveals New Potential Mutations Genes for Primary Mucosa-Associated Lymphoid Tissue Lymphoma Arising From the Kidney.
IDO1 Expression Increased After Neoadjuvant Therapy Predicts Poor Pathologic Response and Prognosis in Esophageal Squamous Cell Carcinoma.
An IL6-Adenosine Positive Feedback Loop between CD73(+) γδTregs and CAFs Promotes Tumor Progression in Human Breast Cancer.
The innate immune effector ISG12a promotes cancer immunity by suppressing the canonical Wnt/β-catenin signaling pathway.
Metformin changes the immune microenvironment of colorectal cancer in patients with type 2 diabetes mellitus.
A Comparison of Splenic Pathologic Change and Immune Function in HBV-Related Portal Hypertension and Chinese Budd-Chiari Syndrome Patients with Hypersplenism.
Single-Cell Transcriptome Analysis Reveals Intratumoral Heterogeneity in ccRCC, which Results in Different Clinical Outcomes.
NIR-Triggered Sequentially Responsive Nanocarriers Amplified Cascade Synergistic Effect of Chemo-Photodynamic Therapy with Inspired Antitumor Immunity.
He Y, Qian Y, Zheng Z, Zhou Y, Li C, Wu Q, Ren M
Human mutation 2026;2026:8861747
Human mutation 2026;2026:8861747
Downregulation of B7-H4 contributes to the synergistic effect of USP2a-targeted/anti-PD-1 combination therapy in EGFR mutant lung cancer.
Sun B, Kong M, Jiang X, Zhu L, Zhang J, Tan L, Wang C, Yuan Z, Chen S, Wang C, Jiang Y, Zhang L
Cancer immunology, immunotherapy : CII 2026 Mar 26;75(4)
Cancer immunology, immunotherapy : CII 2026 Mar 26;75(4)
LIFUS-driven engineered bacteria reprogram immunosuppressive niches via mechano-NOTCH signaling.
Lin L, Li X, Guo W, Xie J, Li X, Guan X, Zhao C, Yin H, Xu H
Cell reports. Medicine 2026 Mar 17;7(3):102658
Cell reports. Medicine 2026 Mar 17;7(3):102658
Diallyl Trisulfide Suppresses Tumor-Associated Macrophage M2-Like Polarization and Recruitment and Improves the Tumor Microenvironment Through Blocking CCL5/STAT3 Signaling Pathway Against Lung Cancer.
Xie C, Yin J, Zhu J
Phytotherapy research : PTR 2026 Jan;40(1):318-333
Phytotherapy research : PTR 2026 Jan;40(1):318-333
Reduced EZH2 Expression in Circulating CD8-Positive T Cells and Monocytes in Psoriasis.
Yamamoto T, Toyoshima R, Li L, Koyama A, Sato S, Shibata S
Experimental dermatology 2026 Jan;35(1):e70207
Experimental dermatology 2026 Jan;35(1):e70207
USP5 inhibition stimulates immunogenic ferroptosis that enhances immunotherapy in diffuse large B-cell lymphoma.
Wu J, Liu C, Chen Q, Deng Y, Wang J, Gao Y, Wei B
Cell communication and signaling : CCS 2026 Jan 5;24(1):93
Cell communication and signaling : CCS 2026 Jan 5;24(1):93
Targeting glucocorticoid receptor to enhance immunotherapy response in triple negative breast cancer.
Yang L, Chen Z, Chen Y, Yang J, Liu S, Deng K, Xu J, Cui M, Fu Z
Breast cancer research : BCR 2026 Jan 29;28(1)
Breast cancer research : BCR 2026 Jan 29;28(1)
Lentiviral Dendritic Cell Vaccine Targeting Claudin-18.2 Elicits Potent Antitumor Immunity Against Gastric Cancer.
Zheng B, Zhang W, Zhou D, Fu M, Lou F, Huang X, Xie X, Gong Y, Rong K, Hong Y, Zhan Y, Xiao L, Hu T
Cancers 2026 Jan 29;18(3)
Cancers 2026 Jan 29;18(3)
ZNF683(+) NK cells govern chemotherapy sensitivity in advanced HPSCC via reshaping immune microenvironment.
Li G, Xiao W, Wu H, Liu C, Gong L, Zhang H, Shao Z, Bai J, Xia X, Yi X, Wang Y, Lu S, She L, Wang J, Zhu G, Zhou X, Wang W, Shen L, Zhang N, Wang X, Huang D, Hou J, Qiu Y, Zhang X, Hung MC, Liu Y
Nature communications 2026 Jan 21;17(1)
Nature communications 2026 Jan 21;17(1)
Aging impairs peroxisome biogenesis in human B cells.
Correia J, Roy PS, Holden KG, Kohut ML, Bai H
The journals of gerontology. Series A, Biological sciences and medical sciences 2026 Jan 12;81(2)
The journals of gerontology. Series A, Biological sciences and medical sciences 2026 Jan 12;81(2)
Adiponectin attenuates atherosclerosis via macrophage polarization-mediated T Cell exhaustion by modulating the NF-κB p65/PI3K/Akt signaling pathway.
Qin M, Xu S, Chen Y, Luo X, Tang X, Zhang L, Xu Q
Tissue & cell 2026 Feb;98:103150
Tissue & cell 2026 Feb;98:103150
Comprehensive tumour-immune profiling reveals TREM2(+) tumour-associated macrophages facilitating lymph node metastasis in head and neck squamous cell carcinoma.
Wu Z, Cheng C, Li Z, Ren M, Cao H, Huang W, Wang J, Wu L, Lee T, Zhang S, Zheng H, Wang Y
Clinical and translational medicine 2026 Feb;16(2):e70604
Clinical and translational medicine 2026 Feb;16(2):e70604
SREBF2 enhances lipid metabolism and represses anti-tumor immune responses in cervical cancer by increasing ACAT2.
Zhang Y, Shao Y, Li X, Zhou D, Zhou J, Yan Q, Gao W, Yang L
Communications biology 2026 Feb 7;9(1)
Communications biology 2026 Feb 7;9(1)
Single-nucleus transcriptomics of an engineered pig model reveals microglia-T cell interactions driving Huntington's disease neurodegeneration.
Li J, Lin Y, Gao J, Yang F, Li C, Chen Y, Huang C, Song X, Song Z, Wu J, Wu J, Wang W, Song J, Shi C, Cao G, Xu Y, Sun Y, Tu Z, Lai L, Li S, Li XJ, Yan S
Nature biomedical engineering 2026 Feb 24;
Nature biomedical engineering 2026 Feb 24;
Tumor-to-endothelium mitochondrial transfer licenses endothelial cells for CD8(+) T cell recognition via mitochondrial neoantigen presentation.
Costabile F, Stefano P, Perales-Linares R, Leli N, Bear A, Koch CJ, Carreno BM, Lotze M, Singh L, Falck M, Facciabene A
bioRxiv : the preprint server for biology 2026 Feb 2;
bioRxiv : the preprint server for biology 2026 Feb 2;
The expression and significance of CXCL13 and CXCR5 in the tumor microenvironment of primary central nervous system diffuse large B-cell lymphoma.
Li C, Zhang L, Jin Q, Jiang H, Yue N, Wu C
Free radical biology & medicine 2026 Feb 16;244:197-209
Free radical biology & medicine 2026 Feb 16;244:197-209
VCAN promotes the progression and recurrence of esophageal squamous cell carcinoma by remodeling the tumor microenvironment.
Guo Z, Feng S, Zhang Y
Scientific reports 2026 Apr 21;
Scientific reports 2026 Apr 21;
SpaHE-Infil: A spatial heterogeneity framework for decoding TME infiltration from H&E-stained slides.
Wang F, Xu H, Wang X, Wu M, Ding S, Duan L, Yang C, Li J, Ge X, Qin Y, Qi X, Mao Y
iScience 2026 Apr 17;29(4):115155
iScience 2026 Apr 17;29(4):115155
Oncolytic adenovirus H101 enhances the anti-tumor effects of PD-1 blockade via CD47 downregulation in tumor cells.
Qiao C, Xu Y, He Y, Cai Z, Wang H
Oncology research 2025;33(5):1161-1172
Oncology research 2025;33(5):1161-1172
Ultrasound-Targeted Nanobubbles Codelivering NKP-1339 and miR-142-5p for Synergistic Mitochondrial Immunogenic Cell Death and PD-L1 Inhibition in Cancer Therapy.
Zhang Y, Liu C, Jin S, Xie L, Xiao Q, Yao J
Biomaterials research 2025;29:0232
Biomaterials research 2025;29:0232
Mannose Inhibits NSCLC Growth and Inflammatory Microenvironment by Regulating Gut Microbiota and Targeting OGT/hnRNP R/JUN/IL-8 Axis.
Jin H, He H, Li J, Liu X, Cai Q, Shi J, Hao Z, He J
International journal of biological sciences 2025;21(4):1566-1584
International journal of biological sciences 2025;21(4):1566-1584
Lung Cancer Cell-intrinsic Asparagine Synthetase Potentiates Anti-Tumor Immunity via Modulating Immunogenicity and Facilitating Immune Remodeling in Metastatic Tumor-draining Lymph Nodes.
Zhang Z, Du N, He G, Zhang M, Zhang G, Gao J, Liu Y, Deng Y, Sun L, Li M
International journal of biological sciences 2025;21(14):6501-6521
International journal of biological sciences 2025;21(14):6501-6521
Single-cell Profiling of Intrahepatic Immune Cells Reveals an Expansion of Tissue-resident Cytotoxic CD4(+) T Lymphocyte Subset Associated With Pathogenesis of Alcoholic-associated Liver Diseases.
Gao C, Wang S, Xie X, Ramadori P, Li X, Liu X, Ding X, Liang J, Xu B, Feng Y, Tan X, Wang H, Zhang Y, Zhang H, Zhang T, Mi P, Li S, Zhang C, Yuan D, Heikenwalder M, Zhang P
Cellular and molecular gastroenterology and hepatology 2025;19(2):101411
Cellular and molecular gastroenterology and hepatology 2025;19(2):101411
CD82-associated exhausted CD8(+) T cells define prognosis and immunotherapy resistance in colon cancer.
Zhang J, Cui H, Wu S, Shi H, Wang H, Jiang J
Frontiers in immunology 2025;16:1731154
Frontiers in immunology 2025;16:1731154
Targeting PDPN enhances antitumor T-cell activity by disrupting β-catenin-mediated PD-L1 expression in melanoma.
Feng C, Liu Y, Zhong X, Wei Z, Cui H, Yi J
Frontiers in immunology 2025;16:1692864
Frontiers in immunology 2025;16:1692864
Single-cell and bulk transcriptomics reveal a CD8(+) T-cell gene signature predicting prognosis in diffuse large B-cell lymphoma.
Liu H, Feng Y, Qian Z, Song Z, Zhang N, Yu J, Liu X, Qiu L, Zhou S, Gong W, Meng B, Abolhassani H, Asghar M, Li L, He J, Zhang H, Wang X
Frontiers in immunology 2025;16:1685541
Frontiers in immunology 2025;16:1685541
Characteristics of tertiary lymphoid structures in prostate cancer and the impact of neoadjuvant therapy on their formation and maturation.
Liu S, Yu Y, Zhou J, Yang L, Yan X, Liu X, Ma K, Liu L, Wang X, Zhao C, Dong Q
Frontiers in immunology 2025;16:1663396
Frontiers in immunology 2025;16:1663396
Radiomic features and tumor immune microenvironment associated with anaplastic lymphoma kinase-rearranged lung adenocarcinoma and their prognostic value.
Han Y, Feng W, Li H, Wang H, Ye Z
Frontiers in genetics 2025;16:1581937
Frontiers in genetics 2025;16:1581937
The key role of DLX6 in nasopharyngeal carcinoma: metastasis, angiogenesis and tumor immune mechanism.
Yang H, Zeng X, Chen X, Cai S, Li Y, Xu W, Lai J, Qiu S
Frontiers in immunology 2025;16:1522580
Frontiers in immunology 2025;16:1522580
NALCN expression is down-regulated and associated with immune infiltration in gastric cancer.
Li X, Wu N, Wang C, Pei B, Ma X, Xie J, Yang W
Frontiers in immunology 2025;16:1512107
Frontiers in immunology 2025;16:1512107
Itraconazole inhibits the Wnt/β-catenin signaling pathway to induce tumor-associated macrophages polarization to enhance the efficacy of immunotherapy in endometrial cancer.
Guan X, Han L
Frontiers in oncology 2025;15:1590095
Frontiers in oncology 2025;15:1590095
Pan-Cancer Analysis of the Prognostic and Immunotherapeutic Value of PDGFB.
Bai Y, Wang X, Wang B
ImmunoTargets and therapy 2025;14:35-49
ImmunoTargets and therapy 2025;14:35-49
Single-cell analysis reveals XCL1+ CD8+ T cells as a therapeutic target in hepatocellular carcinoma.
Li G, Yang F, Li Z, Chen Z, Luo G, Yuan H, Zhao C
Molecular & cellular oncology 2025;12(1):2523085
Molecular & cellular oncology 2025;12(1):2523085
Single-cell multi-omic and spatial profiling of esophageal squamous cell carcinoma reveals the immunosuppressive role of GPR116(+) pericytes in cancer metastasis.
Pei X, Liu Z, Tang L, Zhang J, He Y, Zhuang X, Song Y, Peng S, He Y, Zhao Y, Huang X, Xu Y, Li J, Peng L, Shi X, Zhang F, Liu C, He M, Dai W, Wu L, Law S, Liu J, Wang Z, Li Z, Xu W, Liu Z, Li B
Nature genetics 2025 Oct;57(10):2494-2508
Nature genetics 2025 Oct;57(10):2494-2508
Ferritinophagy Is Involved in the Advanced Glycation End Products-Induced Ferroptosis of Vascular Endothelial Cells in Diabetes Mellitus.
Huang Y, Jin Y, Hu J, Li M, Tian M, Zeng G, Huang R
Journal of cellular and molecular medicine 2025 Oct;29(20):e70857
Journal of cellular and molecular medicine 2025 Oct;29(20):e70857
Loss of Skeletal Muscle Mass Is Associated With Reduced Cytotoxic T Cell Abundance and Poor Survival in Advanced Lung Cancer.
Nie X, Sun Y, van Dijk DPJ, Deng M, Brecheisen R, Wang Z, Xia Q, Olde Damink SMW, Rensen SS
Journal of cachexia, sarcopenia and muscle 2025 Oct;16(5):e70063
Journal of cachexia, sarcopenia and muscle 2025 Oct;16(5):e70063
Tumor-draining lymph nodes respond to immune checkpoint inhibition and orchestrate tumor immune remodeling.
Zhang J, Ma J, Niu Y, Liu J, Wang Z, Guo J, Meng Y, Sun R, Zhang Z, Liu H, Xu J, Zan L, Guan X, Wang X
Cancer immunology, immunotherapy : CII 2025 Oct 6;74(11):326
Cancer immunology, immunotherapy : CII 2025 Oct 6;74(11):326
LZTR1 regulates epithelial MHC-I expression via NF-κB1 to modulate CD8(+) T cells activation.
Jiang R, Fang Z, Wang Y, Huang B, Liu J, Tsoi LC, Bogle R, Zhang Z, Kuang Y, Li X, Dong L, Jin L, Gudjonsson JE, Yin M, Chen X
Cell discovery 2025 Oct 29;11(1):84
Cell discovery 2025 Oct 29;11(1):84
Iron overload-induced ferroptosis in CD8(+) T cells leads to functional abnormalities that promote endometriosis progression.
Wang S, Xu L, Jiao X, Dong X, Zhong Z, Ren Q, Liu X, Yuan M, Wang G
BMC medicine 2025 Oct 27;23(1):588
BMC medicine 2025 Oct 27;23(1):588
Epigenetic suppression of Nrf2-Slc40a1 axis induces ferroptosis and enhances immunotherapy in pancreatic cancer.
Zhang Y, Yu R, Li Q, Song S, Fu Y, Shen X, Xu T, Zhang Y, Liang J, Zhang Z, Xu S, Tang J, Zhao Y, Shen C, Zhuang Y, Zhang J, Wang L, Zou X, Chen D, Lv Y, Zhang S
Journal for immunotherapy of cancer 2025 Oct 23;13(10)
Journal for immunotherapy of cancer 2025 Oct 23;13(10)
ACOX2 destabilizes the MRE11-RAD50-NBS1 complex and boosts anticancer immunity via the cGAS-STING pathway in clear cell renal cell carcinoma.
Ye S, Xu W, Chen Z, Zhu C, Ge Q, Lu J, Chang K, Tian X, Anwaier A, Zhu S, Zhou S, Zhang W, Wang Y, Zhao J, Li L, Shi Y, Cai T, Xu D, Zhou X, Ye D, Zhang H
Molecular cancer 2025 Oct 21;24(1):263
Molecular cancer 2025 Oct 21;24(1):263
Integrating necroptosis and immune landscapes: a multi-omics-derived NecropImmScore stratifies prognosis and therapy in ovarian cancer.
Xu F, Kang S, Xu S
Cancer immunology, immunotherapy : CII 2025 Oct 15;74(11):340
Cancer immunology, immunotherapy : CII 2025 Oct 15;74(11):340
FASN inhibits ferroptosis in breast cancer via USP5 palmitoylation-dependent regulation of GPX4 deubiquitination.
Qian Z, Jiang Y, Cai Y, Gao E, Wang C, Dong J, Wang F, Liu L, Wu D, Zhang F, Wang Y, Ning X, Li Q, You Y, Gu Y, Mei J, Zhao X, Zhang Y
Journal of experimental & clinical cancer research : CR 2025 Oct 14;44(1):289
Journal of experimental & clinical cancer research : CR 2025 Oct 14;44(1):289
AARS1 Implicates Malignancy and Immune Infiltration in Head and Neck Squamous Cell Carcinoma, Serving as a Prognostic Predictor.
Chen S, You Y, Zhu F, Zhang Z, Shi J, Tian Z
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2025 Nov;54(10):1037-1052
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2025 Nov;54(10):1037-1052
NMRK2 leads to the depletion of CD8(+)T cells by mediating the enhancement of NAD(+)-SIRT1-CD38 axis in PRCC-TFE3 rRCC.
Chen Y, Liu X, Wu M, Dong X, Ma W, Feng F, Ding Y, Dong P, Ding W, Zhang L, Liu N, Gan W, Li D
Oncogene 2025 Nov;44(44):4223-4238
Oncogene 2025 Nov;44(44):4223-4238
Integrated single-cell, spatial, and bulk transcriptomics reveal a chromatin regulator-TME prognostic framework guiding precision therapy in cervical cancer.
Tian X, Lin R, Bao J, Pan Y, Liu J, Zhou H, Qu H, Hu D, Wang N
Journal of translational medicine 2025 Nov 6;23(1):1235
Journal of translational medicine 2025 Nov 6;23(1):1235
Blocking CCR1(+) macrophages overcomes resistance to immune checkpoint inhibitors in melanoma.
Su X, Huang R, Kang D, Wang J, Li L, Zou Z
Cell communication and signaling : CCS 2025 Nov 3;23(1):475
Cell communication and signaling : CCS 2025 Nov 3;23(1):475
Co-targeting CDK4/6 enhances anti-cancer activity and alleviates immune-related adverse events of anti-PD-1 antibody for breast cancer.
Hu SW, Yeh MH, He YH, Wei YL, Cheng FJ, Yeh YL, Huynh TK, Liu PT, Hu DW, Chang TH, Wang BW, Chen BR, Lin MC, Lee DY, Hsieh YH, Hsu YM, Tang CH, Ho PC, Hung MC, Huang WC
Cell reports. Medicine 2025 Nov 18;6(11):102429
Cell reports. Medicine 2025 Nov 18;6(11):102429
Planar conjugate donor engineering enhanced photodynamic immunogenic cell death stimulator for efficient Triple-Negative breast cancer immunotherapy.
Yan P, Li F, Qin S, Li Z, Wang X, Xu G, Song W, Sun W, Zhong W
Journal of colloid and interface science 2025 Nov 15;698:138085
Journal of colloid and interface science 2025 Nov 15;698:138085
A matrix stiffness gene signature identifies SLC20A1 as a novel mechano-immunological checkpoint enabling synergistic immunotherapy in pancreatic ductal adenocarcinoma.
Zhao C, Lu Y, He L, Zhang Y, Yin T
Cancer immunology, immunotherapy : CII 2025 Nov 12;74(12):367
Cancer immunology, immunotherapy : CII 2025 Nov 12;74(12):367
Cholesterol biosynthesis induced by radiotherapy inhibits cGAS-STING activation and contributes to colorectal cancer treatment resistance.
Zhu L, Tang Z, Jiang W, Dong Y, Li X, Huang K, Wu T, Xu L, Guo W, Gu Y
Experimental & molecular medicine 2025 May;57(5):1089-1105
Experimental & molecular medicine 2025 May;57(5):1089-1105
Ginseng polysaccharides ameliorate colorectal tumorigenesis through Lachnospiraceae-mediated immune modulation.
Zong G, Deng R, Pan Y, Liu M, Zhu H, Tao R, Shan Y, Wei Z, Lu Y
International journal of biological macromolecules 2025 May;307(Pt 2):142015
International journal of biological macromolecules 2025 May;307(Pt 2):142015
Identification of the "Collagen-Macrophage" sub-category of patients with colorectal cancer as an extension of the CMS4 subtype with THBS2 as a therapeutic target.
Chen S, Jiang Z, Song W, Lu C, Lin Y, Xu S, Xie K, Wan L, Yuan X
BMC gastroenterology 2025 May 8;25(1):342
BMC gastroenterology 2025 May 8;25(1):342
KIF26B promotes bladder cancer progression via activating Wnt/β-catenin signaling in a TRAF2-dependent pathway.
Wang JM, Zhang FH, Xie HY, Liu ZX, Tang YJ, Shu X, Wu YQ, Lu DH, Sun JZ, Ying YF, Ma XY, Zheng XY, Wang X, Liu B, Li JF, Xie LP, Luo JD
Cell reports 2025 May 27;44(5):115595
Cell reports 2025 May 27;44(5):115595
High-Sensitivity PD-L1 Staining Using Clone 73-10 Antibody and Spatial Transcriptomics for Precise Expression Analysis in Non-Tumorous, Intraepithelial Neoplasia, and Squamous Cell Carcinoma of Head and Neck.
Noda Y, Atsumi N, Nakaya T, Iwai H, Tsuta K
Head and neck pathology 2025 May 20;19(1):65
Head and neck pathology 2025 May 20;19(1):65
Neoadjuvant with low-dose radiotherapy, tislelizumab, albumin-bound paclitaxel, and cisplatin for resectable locally advanced head and neck squamous cell carcinoma: phase II single-arm trial.
Liu Z, Wang D, Li G, Yi M, Zhang Z, Zhong G, Xu L, Jiang R, Zheng Y, Huang L, Peng Y, Liang L, Li J, Liu Y, Lai J, Lv X, Xu Y, Liu Q, Wang Z, Liu Z, Yang Q, Nie L, Lei J, Huang X, Liu Z, Jiang W
Nature communications 2025 May 17;16(1):4608
Nature communications 2025 May 17;16(1):4608
Nerve infiltration of bladder cancer predicts response to immunotherapy.
Lu X, Shui KM, Ji H, Chen JY, Yan C, Li P, Xu T
Biochemical and biophysical research communications 2025 May 1;761:151687
Biochemical and biophysical research communications 2025 May 1;761:151687
Radiotherapy-resistant prostate cancer cells escape immune checkpoint blockade through the senescence-related ataxia telangiectasia and Rad3-related protein.
Shao C, Zhang Y, Li H, Chen J, Huang T, Li J, Wen S, Wang S, Fan S, Zhao Y
Cancer communications (London, England) 2025 Mar;45(3):218-244
Cancer communications (London, England) 2025 Mar;45(3):218-244
GLP1 alleviates oleic acid-propelled lipocalin-2 generation by tumor-infiltrating CD8(+) T cells to reduce polymorphonuclear MDSC recruitment and enhances viral immunotherapy in pancreatic cancer.
Wu J, Qian P, Han Y, Xu C, Xia M, Zhan P, Wei J, Dong J
Cellular & molecular immunology 2025 Mar;22(3):282-299
Cellular & molecular immunology 2025 Mar;22(3):282-299
Cryo-trojan mesenchymal stem cells as non-living tumor-homing supercarriers for enhanced drug delivery and immune activation in prostate cancer.
Wang C, Rong X, Zhang F, Mu X, Jiang J
Materials today. Bio 2025 Jun;32:101650
Materials today. Bio 2025 Jun;32:101650
Spatial determinants of antibody-drug conjugate SHR-A1811 efficacy in neoadjuvant treatment for HER2-positive breast cancer.
Ma D, Dai LJ, Wu XR, Liu CL, Zhao S, Zhang H, Chen L, Xiao Y, Li M, Zhao YZ, Yang L, Zhou T, Li JJ, Yang WT, Jiang YZ, Shao ZM
Cancer cell 2025 Jun 9;43(6):1061-1075.e7
Cancer cell 2025 Jun 9;43(6):1061-1075.e7
LMNB2-mediated high PD-L1 transcription triggers the immune escape of hepatocellular carcinoma.
Li Y, Zhu J, Zhai F, Ge Y, Zhan Z, Wang S, Kong L, Zhao J, Hu L, Wang S, Shi J, Mao J, Yu Z, Wang H, Jin J, Zhao M, Li H, Jin X
Cell death discovery 2025 Jun 7;11(1):269
Cell death discovery 2025 Jun 7;11(1):269
Spatial Transcriptome Analysis of B7-H4 in Head and Neck Squamous Cell Carcinoma: A Novel Therapeutic Target for Anti-Immune Checkpoint Inhibitors.
Noda Y, Yagi M, Tsuta K
Head and neck pathology 2025 Jun 30;19(1):78
Head and neck pathology 2025 Jun 30;19(1):78
HIC1 suppresses Tumor Progression and Enhances CD8(+) T Cells Infiltration Through Promoting GSDMD-induced Pyroptosis in Gastric Cancer.
Kang M, Du W, Ding L, Wu M, Pei D
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(26):e2412083
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(26):e2412083
MIAT promotes tumor-infiltrating CD8(+) T-cell exhaustion and malignant progression of renal cell carcinoma via activating JAK3/STAT3 pathway.
Zhang MX, Jing LY, Tan HT, Dai ZR, Long DZ, Liu HC, Yu AZ, Wang B, Chen ZY, Luo JH, Chen ZH, Wang JF
Journal for immunotherapy of cancer 2025 Jul 31;13(7)
Journal for immunotherapy of cancer 2025 Jul 31;13(7)
Glutamine binds HSC70 to transduce signals inhibiting IFN-β-mediated immunogenic cell death.
Zhang D, Song S, Lin J, Ye T, Yang X, Jiang Q, Mi Y, Zhang M, Ge X, Shen Y, Du P, Shi Y, Zhang X, Li L, Zhang Y, Ding L, Liu J, Zhang Y, Gao S, Ye Q
Developmental cell 2025 Jul 21;60(14):1958-1973.e9
Developmental cell 2025 Jul 21;60(14):1958-1973.e9
Machine learning-based integration develops a hypoxia-derived signature for improving outcomes in glioma.
Zhou Q, Zhou Z, Guo Y, Yan X, Jiang X, Du C, Ke Y
iScience 2025 Jul 18;28(7):112023
iScience 2025 Jul 18;28(7):112023
Histone deacetylases 10 as a prognostic biomarker correlates with tumor microenvironment and therapy response in colorectal cancer.
Nie HH, Yang XY, Zhou JK, Gao GL, Ding L, Hong YT, Yu YL, Qiu PS, Zeng ZY, Lai J, Zheng T, Wang HZ, Zhao Q, Wang F
World journal of gastroenterology 2025 Jul 14;31(26):108662
World journal of gastroenterology 2025 Jul 14;31(26):108662
Molecular mechanism differences between nanoplastics and microplastics in colon toxicity: nanoplastics induce ferroptosis-mediated immunogenic cell death, while microplastics cause cell metabolic reprogramming.
Cheng Y, Chen J, Fu R, Zhang P, Chen H, Cao H, Jiang Z, Hong Y, Li Y, He C, Tao F, Li T, Zhang J, Chen B, Cao G
Journal of nanobiotechnology 2025 Jul 14;23(1):505
Journal of nanobiotechnology 2025 Jul 14;23(1):505
TMOD3 accelerated resistance to immunotherapy in KRAS-mutated pancreatic cancer through promoting autophagy-dependent degradation of ASCL4.
He Z, Zheng D, Li F, Chen L, Wu C, Zeng Z, Yu C
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2025 Jan;78:101171
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2025 Jan;78:101171
Single-cell transcriptomic analysis of the senescent microenvironment in bone metastasis.
Wang S, Ao L, Lin H, Wei H, Wu Z, Lu S, Liang F, Shen R, Zhang H, Miao T, Shen X, Lin J, Zhong G
Cell proliferation 2025 Jan;58(1):e13743
Cell proliferation 2025 Jan;58(1):e13743
B7-H3 and CD39 Co-Localization in Gastric Cancer: A Potential Prognostic Biomarker and Potential Dual-Target for Immunotherapy.
Zhang Q, Liu Y, Xuan H, Zhan S, Shen Y, Wang R, Chen S, Ding S, Liu C, Huang L, Ma Q, Jiang T, Cao L
Technology in cancer research & treatment 2025 Jan-Dec;24:15330338251380957
Technology in cancer research & treatment 2025 Jan-Dec;24:15330338251380957
Discovery of Potent and Selective CDK4/6 Inhibitors for the Treatment of Chemotherapy-Induced Myelosuppression.
Shi W, Wang R, Qian J, Wang L, Li Y, Mi Y, Jia Z, Pan M, Zhang X, Ye W, Xiong F, Hu X, Wang H
Journal of medicinal chemistry 2025 Jan 23;68(2):1446-1472
Journal of medicinal chemistry 2025 Jan 23;68(2):1446-1472
Identifying effective immune biomarkers in alopecia areata diagnosis based on machine learning methods.
Zhou Q, Lan L, Wang W, Xu X
BMC medical informatics and decision making 2025 Jan 14;25(1):23
BMC medical informatics and decision making 2025 Jan 14;25(1):23
Itaconate transporter SLC13A3 confers immunotherapy resistance via alkylation-mediated stabilization of PD-L1.
Fan Y, Dan W, Wang Y, Ma Z, Jian Y, Liu T, Li M, Wang Z, Wei Y, Liu B, Ding P, Lei Y, Guo C, Zeng J, Yan X, Wei W, Li L
Cell metabolism 2025 Feb 4;37(2):514-526.e5
Cell metabolism 2025 Feb 4;37(2):514-526.e5
VPS25 Promotes an Immunosuppressive Microenvironment in Head and Neck Squamous Cell Carcinoma.
Chen LG, Fang YH, Wang KM, Zhang W, Chen G
Biomolecules 2025 Feb 22;15(3)
Biomolecules 2025 Feb 22;15(3)
ANLN promotes head and neck squamous cell carcinoma progression by upregulating PD-L1 via the ERK-MAPK pathway.
Wang L, Wang J, Wang N, Wang X, Song M, Zhou Y, Wang Z, Meng H, Guo E, Miao S
iScience 2025 Feb 21;28(2):111633
iScience 2025 Feb 21;28(2):111633
Bispecific antibody simultaneously targeting AGR2 and PD1 mediates cytotoxic T-cell-induced antitumor response in AGR2-dependent manner and inhibits AGR2-induced PDL1 upregulation.
Roy D, He Y, Wang Y, Xu P, Jin B, Xiao H, Li D, Zhao B
Scientific reports 2025 Feb 19;15(1):6015
Scientific reports 2025 Feb 19;15(1):6015
Yin Yang 1 Promotes Antiprogrammed Cell Death-1 Resistance in Hepatocellular Carcinoma through Polypeptide N-Acetylgalactosaminyltransferase 16-Mediated Glycosylation of Programmed Death Ligand-1.
Lin SS, Xiao G, Liu QQ, Xue JH, Chen ZJ, Zhang HH, Zhu XP, Huang KL, Yang CN, Zhu K, Lin HM, Zhang R
MedComm 2025 Dec;6(12):e70504
MedComm 2025 Dec;6(12):e70504
YBX1 is required for maintaining PD-L1 expression in intrahepatic cholangiocarcinoma by regulating STAT1 stability in an m5C-dependent manner.
Sun XY, Yu B, Yu J, Wang YP, Li XB, Sun RR, Tian X, Kan QC
Hepatobiliary & pancreatic diseases international : HBPD INT 2025 Dec;24(6):643-655
Hepatobiliary & pancreatic diseases international : HBPD INT 2025 Dec;24(6):643-655
FOXO1-driven metabolic reprogramming of hematomal CD8(+) T cells drives the expansion of perihematomal edema following intracerebral hemorrhage.
Lin J, Ren H, Wang Y, Yu H, Chen Z, Yu X, Gao Z, Zheng Y, Wu Q, Zhang Y, Lin Q, Li R, Tian D, Cai Z, Liu Q, Fu Y
Cellular & molecular immunology 2025 Dec;22(12):1629-1641
Cellular & molecular immunology 2025 Dec;22(12):1629-1641
Resveratrol amplifies the anti-tumor effect of α-PD-1 by altering the intestinal microbiome and PGD2 content.
Luo B, An Q, Lei J, Tan D, Liu X, Li H, Zhao Y, Qin J, Zhang C, Zhang Y, Shi C
Gut microbes 2025 Dec;17(1):2447821
Gut microbes 2025 Dec;17(1):2447821
Mature tertiary lymphoid structures support B cell-mediated antitumour immunity and are disrupted by neoadjuvant therapy in rectal cancer: a multicentre, retrospective study.
Tian N, Wang Q, Lv Y, Zhong W, Li W, Cai H, An R, Zhu H, Sun L, Yuan Q, Dong X, Dong J, Bai J, Liu A, Chen G, Wu B, Du J
EBioMedicine 2025 Dec;122:106030
EBioMedicine 2025 Dec;122:106030
Spatial Transcriptomics and snRNA-seq Expose CAF Niches Orchestrating Dual Stromal-Immune Barriers in Hepatocellular Carcinoma.
Li Y, Huan C, Sun H, Zhang W, Guo Z, Li C, Yao J, Zhang Z, Yu S, Dong Q, Qin L, Li J, Zhou L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(48):e14661
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(48):e14661
KIAA1429 impairs anti-tumor immunity via regulation of PD-L1 and CD8(+) T cells in colorectal cancer.
Du Y, Liu Y, Wang M, Wang Y, Lin M
Scientific reports 2025 Dec 4;15(1):43619
Scientific reports 2025 Dec 4;15(1):43619
Metformin reshapes the tumor microenvironment and enhances prognosis in invasive pancreatic ductal adenocarcinoma with diabetes mellitus.
Takahashi R, Saito A, Miyato H, Kimura Y, Aoki Y, Taguchi M, Morishima K, Ohzawa H, Endo K, Sasanuma H, Yamaguchi H, Kawahira H, Horie H, Hosoya Y, Mimura T, Kitayama J, Sata N
Journal of gastrointestinal oncology 2025 Dec 31;16(6):2814-2826
Journal of gastrointestinal oncology 2025 Dec 31;16(6):2814-2826
OX40L and IL-2 combination strategy for gastric cancer immunotherapy.
Hu B, Garbarino E, Ma J, Yan C, Jia J, Xie H, Li L, Jin C, Xue Y, Tang H
Translational cancer research 2025 Dec 31;14(12):8807-8824
Translational cancer research 2025 Dec 31;14(12):8807-8824
Histone deacetylase HDAC7 restricts CD8 + T cell tumor infiltration and limits immunotherapy sensitivity in bladder cancer: reversal by pinocembrin.
Lv J, Li K, Zhou J, Yu R, Lu Q, Liu B
Journal of experimental & clinical cancer research : CR 2025 Dec 24;44(1):324
Journal of experimental & clinical cancer research : CR 2025 Dec 24;44(1):324
Screening and identification Hub genes associated with immune cell infiltration and critical biomarkers in osteosarcoma.
Song X, Chen S, Cheng J, Li H, Wu R, Yan M, Wang M, Li J, Jin A, Wang W
Molecular and cellular probes 2025 Aug;82:102031
Molecular and cellular probes 2025 Aug;82:102031
Immunogenic cuproptosis in cancer immunotherapy via an in situ cuproptosis-inducing system.
Li J, Zhang G, Sun Z, Jiang M, Jia G, Liu H, Liu N, Shi L, Zhang L, Nie L, Zhang Y, Fu Y
Biomaterials 2025 Aug;319:123201
Biomaterials 2025 Aug;319:123201
A novel FTO-targeting nanodrug induces disulfidptosis and ameliorates the suppressive tumor immune environment to treat uveal melanoma.
Tian H, Deng H, Liu X, Liu C, Zhang C, Leong KW, Fan X, Ruan J
Biomaterials 2025 Aug;319:123168
Biomaterials 2025 Aug;319:123168
C-Reactive Protein to Lymphocyte Ratio (CLR) and Lactate Dehydrogenase to Albumin Ratio (LAR) as Prognostic Biomarkers in Acral Melanoma: Association With Tertiary Lymphoid Structures and Immune Cell Infiltration.
Kang D, Su X, Wang J, Zhao L, Huang R, Zou Z
Cancer medicine 2025 Aug;14(15):e71078
Cancer medicine 2025 Aug;14(15):e71078
Biomineralized Albumin-Macrocyclic Conjugates for Synergistic Metal Ion-Based Combination Therapy in Cancer Treatment.
Zhang Y, Ke Y, Li S, Cai X, Li S, Shao Y, Chen X, Zhang Z, Sun SK
ACS nano 2025 Aug 26;19(33):30383-30395
ACS nano 2025 Aug 26;19(33):30383-30395
Spautin-1 inhibits the growth of diffuse large B-cell lymphoma by inducing mitochondrial damage-mediated PANoptosis and anti-tumor immunity.
Wu J, Deng Y, Gao Y, Wei B
Cancer immunology, immunotherapy : CII 2025 Aug 25;74(9):293
Cancer immunology, immunotherapy : CII 2025 Aug 25;74(9):293
CAD hijacks STING to impair antitumor immunity and radiotherapy efficacy of colorectal cancer.
Cai Z, Cheng Z, Zhang L, Zhang Y, Shi J, Jin J, Mi Z, Yuan Z, Wu Z
Cell death & disease 2025 Aug 23;16(1):641
Cell death & disease 2025 Aug 23;16(1):641
Proteomics and single cell profiling identify keratin driven preexisting immunity influences lung squamous carcinoma neoadjuvant therapy.
Zhao J, Shen M, Xu X, Ji S, Xu S, Xu L, Yang Y, Ye M, Lu Y, Wang P, Wang K
Cancer letters 2025 Aug 22;633:218000
Cancer letters 2025 Aug 22;633:218000
Pseudogene pair-based prognostic model reveals LAT as a biomarker of immune response in head and neck squamous cell carcinoma.
Ding Q, Hong W, Chen G, Lin T, Chen X, Yang H, Xu W, Hong X, Lai J, Qiu S, Lu J
Discover oncology 2025 Aug 11;16(1):1528
Discover oncology 2025 Aug 11;16(1):1528
Integrated multi-omics reveal lactate metabolism-related gene signatures and PYGL in predicting HNSCC prognosis and immunotherapy efficacy.
Chen X, Jiang Z, Pan J, Xu W, Li Y, Chen X, Pan Y, Weng Y, Hu D, Qiu S
BMC cancer 2025 Apr 24;25(1):773
BMC cancer 2025 Apr 24;25(1):773
GPX2 inhibition enhances antitumor efficacy of lenvatinib via promoting immunogenic cell death in hepatocellular carcinoma.
Tan Y, Yang L, Xu T, Wang Q, Huang M, Zhao Z, Chen X, Tang C, Tan W
Journal of translational medicine 2025 Apr 18;23(1):456
Journal of translational medicine 2025 Apr 18;23(1):456
Proteogenomic characterization of non-functional pancreatic neuroendocrine tumors unravels clinically relevant subgroups.
Ji S, Cao L, Gao J, Du Y, Ye Z, Lou X, Liu F, Zhang Y, Xu J, Shi X, Wang H, Li P, Li Y, Chen H, Yang Z, Gao S, Zhang W, Huang D, Ni S, Wei M, Wang F, Wang Y, Ding T, Jing D, Fan G, Gong Z, Lu R, Qin Y, Chen J, Xu X, Wang P, Zhang B, Ding L, Robles AI, Rodriguez H, Chang DK, Hruban RH, Gao D, Gao D, Jin G, Zhou H, Wu J, Yu X
Cancer cell 2025 Apr 14;43(4):776-796.e14
Cancer cell 2025 Apr 14;43(4):776-796.e14
Reduced Abundance of Phocaeicola in Mucosa-associated Microbiota Is Associated with Distal Colorectal Cancer Metastases Possibly through an Altered Local Immune Environment.
Ota G, Inoue R, Saito A, Kono Y, Kitayama J, Sata N, Horie H
Journal of the anus, rectum and colon 2024;8(3):235-245
Journal of the anus, rectum and colon 2024;8(3):235-245
SPOP expression is associated with tumor-infiltrating lymphocytes in pancreatic cancer.
Yang XJ, Xu YF, Zhu Q
PloS one 2024;19(7):e0306994
PloS one 2024;19(7):e0306994
Coactosin-Like Protein 1 (COTL1) Could Be an Immunological and Prognostic Biomarker: From Pan-Cancer Analysis to Low-Grade Glioma Validation.
Wang X, Bai Y, Wang B
Journal of inflammation research 2024;17:1805-1820
Journal of inflammation research 2024;17:1805-1820
The development of anti-PD-1 antibody-induced spinal cord injury in bone marrow transplant C57BL/6 Rag1(-/-) mouse model.
Chen H, Lu Z, Ni X, Zhang H, Chen G, Wu X, Ding M
Immunotherapy 2024;16(14-15):975-985
Immunotherapy 2024;16(14-15):975-985
The cancer-associated fibroblasts interact with malignant T cells in mycosis fungoides and promote the disease progression.
Zhao Y, Li Y, Wang P, Zhu M, Wang J, Xie B, Tang C, Ma Y, Wang S, Jin S, Xu J, Li Z, Zhang X, Li L, Song X, Wang P
Frontiers in immunology 2024;15:1474564
Frontiers in immunology 2024;15:1474564
Neoadjuvant immunochemotherapy improves clinical outcomes of patients with esophageal cancer by mediating anti-tumor immunity of CD8+ T (Tc1) and CD16+ NK cells.
He Y, Yang D, Lin X, Zhang J, Cheng R, Cao L, Yang L, Zhang M, Shi X, Jin X, Sun H, Sun H, Zang J, Li Y, Ma J, Nie H
Frontiers in immunology 2024;15:1412693
Frontiers in immunology 2024;15:1412693
Platinum-based neoadjuvant chemotherapy upregulates STING/IFN pathway expression and promotes TILs infiltration in NSCLC.
Gao H, Zhang X, Ren M, Jiang A, Liu N, Wang J, Zheng X, Liang X, Ruan Z, Tian T, Fu X, Yao Y
Frontiers in oncology 2024;14:1346225
Frontiers in oncology 2024;14:1346225
Serotonylation in tumor-associated fibroblasts contributes to the tumor-promoting roles of serotonin in colorectal cancer.
Ling T, Dai Z, Wang H, Kien TT, Cui R, Yu T, Chen J
Cancer letters 2024 Sep 28;600:217150
Cancer letters 2024 Sep 28;600:217150
Intratumoral microbiota as a novel prognostic indicator in bladder cancer.
Zhang Y, Lin H, Liang L, Jin S, Lv J, Zhou Y, Xu F, Liu F, Feng N
Scientific reports 2024 Sep 27;14(1):22198
Scientific reports 2024 Sep 27;14(1):22198
Activation of Wnt/β-catenin signaling promotes immune evasion via the β-catenin/IKZF1/CCL5 axis in hepatocellular carcinoma.
Huang Y, Peng M, Yu W, Li H
International immunopharmacology 2024 Sep 10;138:112534
International immunopharmacology 2024 Sep 10;138:112534
Exploring the impact of PDGFD in osteosarcoma metastasis through single-cell sequencing analysis.
Huang Y, Cao D, Zhang M, Yang Y, Niu G, Tang L, Shen Z, Zhang Z, Bai Y, Min D, He A
Cellular oncology (Dordrecht, Netherlands) 2024 Oct;47(5):1715-1733
Cellular oncology (Dordrecht, Netherlands) 2024 Oct;47(5):1715-1733
ZG16 enhances the maturation of dendritic cells via induction of CD40 and contributes to the antitumor immunity in pancreatic cancer.
Meng H, Li L, Nan M, Ding Y, Li Y, Zhang M
Oncogene 2024 Oct;43(43):3184-3196
Oncogene 2024 Oct;43(43):3184-3196
FAT10 induces immune suppression by upregulating PD-L1 expression in hepatocellular carcinoma.
Wang Q, Tan W, Zhang Z, Chen Q, Xie Z, Yang L, Tang C, Zhuang H, Wang B, Jiang J, Ma X, Wang W, Hua Y, Shang C, Chen Y
Apoptosis : an international journal on programmed cell death 2024 Oct;29(9-10):1529-1545
Apoptosis : an international journal on programmed cell death 2024 Oct;29(9-10):1529-1545
snRNA-seq of adipose tissues reveals the potential cellular and molecular mechanisms of cold and disease resistance in Mongolian cattle.
Chi Z, Jia Q, Yang H, Ren H, Jin C, He J, Wuri N, Sui Z, Zhang J, Mengke B, Zhu L, Qiqi G, Aierqing S, Wuli J, Ai D, Fan R, Herrid M
BMC genomics 2024 Oct 25;25(1):999
BMC genomics 2024 Oct 25;25(1):999
Clinical-proteomic classification and precision treatment strategy of chordoma.
Yin H, Hu J, Gao J, Su T, Jin J, Jiang C, Yin W, Xu X, Chang Z, Sun W, Cai Z, Zhou W, Wang P, Lin J, Song D, Meng T
Cell reports. Medicine 2024 Oct 15;5(10):101757
Cell reports. Medicine 2024 Oct 15;5(10):101757
Local TSH/TSHR signaling promotes CD8(+) T cell exhaustion and immune evasion in colorectal carcinoma.
Zeng S, Hu H, Li Z, Hu Q, Shen R, Li M, Liang Y, Mao Z, Zhang Y, Zhan W, Zhu Q, Wang F, Xiao J, Xu B, Liu G, Wang Y, Li B, Xu S, Zhang Z, Zhang C, Wang Z, Liang L
Cancer communications (London, England) 2024 Nov;44(11):1287-1310
Cancer communications (London, England) 2024 Nov;44(11):1287-1310
Crosstalk between GBP2 and M2 macrophage promotes the ccRCC progression.
Zheng W, Ye S, Liu B, Liu D, Yan R, Guo H, Yu H, Hu X, Zhao H, Zhou K, Li G
Cancer science 2024 Nov;115(11):3570-3586
Cancer science 2024 Nov;115(11):3570-3586
Tumor microenvironment remodeling after neoadjuvant chemoradiotherapy in local advanced rectal cancer revealed by single-cell RNA sequencing.
Su W, Ling Y, Yang X, Wu Y, Xing C
Journal of translational medicine 2024 Nov 18;22(1):1037
Journal of translational medicine 2024 Nov 18;22(1):1037
Integrative analysis of the cuproptosis-related gene ATP7B in the prognosis and immune infiltration of IDH1 wild-type glioma.
Zhang K, Qu C, Zhou P, Yang Z, Wu X
Gene 2024 May 5;905:148220
Gene 2024 May 5;905:148220
GGT5: a potential immunotherapy response inhibitor in gastric cancer by modulating GSH metabolism and sustaining memory CD8+ T cell infiltration.
Zhao W, Liang Z, Yao Y, Ge Y, An G, Duan L, Yao J
Cancer immunology, immunotherapy : CII 2024 May 15;73(7):131
Cancer immunology, immunotherapy : CII 2024 May 15;73(7):131
NDRG1 overcomes resistance to immunotherapy of pancreatic ductal adenocarcinoma through inhibiting ATG9A-dependent degradation of MHC-1.
Zhang Z, Song B, Wei H, Liu Y, Zhang W, Yang Y, Sun B
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2024 Mar;73:101040
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2024 Mar;73:101040
Targeting autophagy overcomes cancer-intrinsic resistance to CAR-T immunotherapy in B-cell malignancies.
Tang L, Zhang H, Zhou F, Wei Q, Du M, Wu J, Li C, Luo W, Zhou J, Wang X, Chen Z, Zhang Y, Huang Z, Wu Z, Wen Y, Jiang H, Liao D, Kou H, Xiong W, Mei H, Hu Y
Cancer communications (London, England) 2024 Mar;44(3):408-432
Cancer communications (London, England) 2024 Mar;44(3):408-432
Pirin Inhibits FAS-Mediated Apoptosis to Support Colorectal Cancer Survival.
Ma H, Suleman M, Zhang F, Cao T, Wen S, Sun D, Chen L, Jiang B, Wang Y, Lin F, Wang J, Li B, Li Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(10):e2301476
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Mar;11(10):e2301476
Modified Biejia Jianwan decoction restrains PD-L1-mediated immune evasion through the HIF-1α/STAT3/NF-κB signaling pathway.
Tian X, Liu F, Wang Z, Zhang J, Liu Q, Zhang Y, Zhang D, Huang C, Zhao J, Jiang S
Journal of ethnopharmacology 2024 Mar 25;322:117577
Journal of ethnopharmacology 2024 Mar 25;322:117577
WTAP regulates the production of reactive oxygen species, promotes malignant progression, and is closely related to the tumor microenvironment in glioblastoma.
Ji Q, Guo Y, Li Z, Zhang X
Aging 2024 Mar 25;16(6):5601-5617
Aging 2024 Mar 25;16(6):5601-5617
The construction of modular universal chimeric antigen receptor T (MU-CAR-T) cells by covalent linkage of allogeneic T cells and various antibody fragments.
Chen T, Deng J, Zhang Y, Liu B, Liu R, Zhu Y, Zhou M, Lin Y, Xia B, Lin K, Ma X, Zhang H
Molecular cancer 2024 Mar 11;23(1):53
Molecular cancer 2024 Mar 11;23(1):53
Pan-Cancer Single-Cell and Spatial-Resolved Profiling Reveals the Immunosuppressive Role of APOE+ Macrophages in Immune Checkpoint Inhibitor Therapy.
Liu C, Xie J, Lin B, Tian W, Wu Y, Xin S, Hong L, Li X, Liu L, Jin Y, Tang H, Deng X, Zou Y, Zheng S, Fang W, Cheng J, Dai X, Bao X, Zhao P
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jun;11(23):e2401061
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jun;11(23):e2401061
GSK0660 enhances antitumor immunotherapy by reducing PD-L1 expression.
Khan B, Chen M, Wang H, Khan A, Hussain S, Shi J, Yang L, Hou Y
European journal of pharmacology 2024 Jun 5;972:176565
European journal of pharmacology 2024 Jun 5;972:176565
Increase in GPIHBP1 expression in advanced stage colorectal cancer indicates poor immune surveillance.
Gao M, Liao L, Lin Z, Hu X, Jia L, Gong W, Jia X
Translational cancer research 2024 Jun 30;13(6):2691-2703
Translational cancer research 2024 Jun 30;13(6):2691-2703
Memory/Active T-Cell Activation Is Associated with Immunotherapeutic Response in Fumarate Hydratase-Deficient Renal Cell Carcinoma.
Chen J, Hu X, Zhao J, Yin X, Zheng L, Guo J, Chen J, Wang Y, Sheng X, Dong H, Liu X, Zhang X, Liang J, Liu H, Yao J, Liu J, Shen Y, Chen Z, He Z, Wang Y, Chen N, Nie L, Zhang M, Pan X, Chen Y, Liu H, Zhang Y, Tang Y, Zhu S, Zhao J, Dai J, Wang Z, Zeng Y, Wang Z, Huang H, Liu Z, Shen P, Zeng H, Sun G
Clinical cancer research : an official journal of the American Association for Cancer Research 2024 Jun 3;30(11):2571-2581
Clinical cancer research : an official journal of the American Association for Cancer Research 2024 Jun 3;30(11):2571-2581
Distinctive multicellular immunosuppressive hubs confer different intervention strategies for left- and right-sided colon cancers.
Liu B, Li S, Cheng Y, Song P, Xu M, Li Z, Shao W, Xin J, Fu Z, Gu D, Du M, Zhang Z, Wang M
Cell reports. Medicine 2024 Jun 18;5(6):101589
Cell reports. Medicine 2024 Jun 18;5(6):101589
Rosmarinic acid activates the Ras/Raf/MEK/ERK signaling pathway to regulate CD8+ T cells and autophagy to clear Chlamydia trachomatis in reproductive tract-infected mice.
Yun ZS, Zhihua S, Xuelian T, Min X, Rongjing H, Mei L
Molecular immunology 2024 Jul;171:105-114
Molecular immunology 2024 Jul;171:105-114
Anti-VEGFR2-Interferon α Promotes the Infiltration of CD8+ T Cells in Colorectal Cancer by Upregulating the Expression of CCL5.
Huang L, Gao R, Nan L, Qi J, Yang S, Shao S, Xie J, Pan M, Qiu T, Zhang J
Journal of immunotherapy (Hagerstown, Md. : 1997) 2024 Jul-Aug 01;47(6):195-204
Journal of immunotherapy (Hagerstown, Md. : 1997) 2024 Jul-Aug 01;47(6):195-204
Effect and mechanism of T lymphocytes on human induced pluripotent stem cell-derived cardiomyocytes via Proteomics.
Ye J, Xu S, Liu X, Zhang Q, Li X, Zhang H, Ma J, Leng L, Zhang S
Stem cell research & therapy 2024 Jul 29;15(1):236
Stem cell research & therapy 2024 Jul 29;15(1):236
Systematic pan-cancer analysis insights into ICAM1 as an immunological and prognostic biomarker.
Yang C, Ni B, Shen L, Li Z, Zhou L, Wu H, Zhang Y, Liu L, Liu J, Tian L, Yan L, Jin X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jul 15;38(13):e23802
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jul 15;38(13):e23802
Transdermal delivery of Fn14 siRNA using a novel composite ionic liquid for treatment of psoriasis-like skin lesions.
Li L, Wu X, Wu J, Zhang X, Miao F, Wang J, Lu J, Liu J, Chen Z, Tai Z, Zhu Q
Journal of controlled release : official journal of the Controlled Release Society 2024 Jan;365:818-832
Journal of controlled release : official journal of the Controlled Release Society 2024 Jan;365:818-832
Gut microbiota modulate CD8(+) T cell immunity in gastric cancer through Butyrate/GPR109A/HOPX.
Yu X, Ou J, Wang L, Li Z, Ren Y, Xie L, Chen Z, Liang J, Shen G, Zou Z, Zhao C, Li G, Hu Y
Gut microbes 2024 Jan-Dec;16(1):2307542
Gut microbes 2024 Jan-Dec;16(1):2307542
Pumilio1 regulates NPM3/NPM1 axis to promote PD-L1-mediated immune escape in gastric cancer.
Wang H, Zhou Z, Zhang J, Hao T, Wang P, Wu P, Su R, Yang H, Deng G, Chen S, Gu L, He Y, Zeng L, Zhang C, Yin S
Cancer letters 2024 Jan 28;581:216498
Cancer letters 2024 Jan 28;581:216498
UPP1 promotes lung adenocarcinoma progression through the induction of an immunosuppressive microenvironment.
Li Y, Jiang M, Aye L, Luo L, Zhang Y, Xu F, Wei Y, Peng D, He X, Gu J, Yu X, Li G, Ge D, Lu C
Nature communications 2024 Feb 8;15(1):1200
Nature communications 2024 Feb 8;15(1):1200
Blockade of C5a receptor unleashes tumor-associated macrophage antitumor response and enhances CXCL9-dependent CD8(+) T cell activity.
Luan X, Lei T, Fang J, Liu X, Fu H, Li Y, Chu W, Jiang P, Tong C, Qi H, Fu Y
Molecular therapy : the journal of the American Society of Gene Therapy 2024 Feb 7;32(2):469-489
Molecular therapy : the journal of the American Society of Gene Therapy 2024 Feb 7;32(2):469-489
PTPRZ1 dephosphorylates and stabilizes RNF26 to reduce the efficacy of TKIs and PD-1 blockade in ccRCC.
Ma Y, Li W, Liu X, Peng W, Qing B, Ren S, Liu W, Chen X
Oncogene 2024 Dec;43(50):3633-3644
Oncogene 2024 Dec;43(50):3633-3644
Crosstalk between cancer-associated fibroblasts and non-neuroendocrine tumor cells in small cell lung cancer involves in glycolysis and antigen-presenting features.
Lu Y, Li H, Zhao P, Wang X, Shao W, Liu Y, Tian L, Zhong R, Liu H, Cheng Y
Molecular medicine (Cambridge, Mass.) 2024 Dec 25;30(1):274
Molecular medicine (Cambridge, Mass.) 2024 Dec 25;30(1):274
Nicotinamide metabolism face-off between macrophages and fibroblasts manipulates the microenvironment in gastric cancer.
Jiang Y, Wang Y, Chen G, Sun F, Wu Q, Huang Q, Zeng D, Qiu W, Wang J, Yao Z, Liang B, Li S, Wu J, Huang N, Wang Y, Chen J, Zhai X, Huang L, Xu B, Yamamoto M, Tsukamoto T, Nomura S, Liao W, Shi M
Cell metabolism 2024 Aug 6;36(8):1806-1822.e11
Cell metabolism 2024 Aug 6;36(8):1806-1822.e11
Identification and Characterization of a Novel B Cell Epitope of ASFV Virulence Protein B125R Monoclonal Antibody.
Zhao Y, Ren H, Lin Z, Shi S, Zhang B, Zhang Y, Han S, He WR, Wan B, Hu M, Zhang GP
Viruses 2024 Aug 5;16(8)
Viruses 2024 Aug 5;16(8)
Gasdermin-E-mediated pyroptosis drives immune checkpoint inhibitor-associated myocarditis via cGAS-STING activation.
Sun SJ, Jiao XD, Chen ZG, Cao Q, Zhu JH, Shen QR, Liu Y, Zhang Z, Xu FF, Shi Y, Tong J, Ouyang SX, Fu JT, Zhao Y, Ren J, Li DJ, Shen FM, Wang P
Nature communications 2024 Aug 5;15(1):6640
Nature communications 2024 Aug 5;15(1):6640
ENG is a Biomarker of Prognosis and Angiogenesis in Liver Cancer, and Promotes the Differentiation of Tumor Cells into Vascular ECs.
Shi S, Zhu C, Hu Y, Jiang P, Zhao J, Xu Q
Frontiers in bioscience (Landmark edition) 2024 Aug 30;29(9):315
Frontiers in bioscience (Landmark edition) 2024 Aug 30;29(9):315
Immunomodulation in Endometriosis: Investigating the interrelationship between VISTA expression and Escherichia.Shigella-Associated metabolites.
Chen Y, Che X, Rong Y, Zhu J, Yu Y, Xu H, Sun Y, Chen H, Yan L, Chen L, Xu Y, Zhang J
International immunopharmacology 2024 Aug 20;137:112366
International immunopharmacology 2024 Aug 20;137:112366
The prognostic value of CD8(+) CTLs, CD163(+) TAMs, and PDL1 expression in the tumor microenvironment of primary central nervous system lymphoma.
Jin Q, Jiang H, Yue N, Zhang L, Li C, Dong C, Zeng P, Yue L, Wu C
Leukemia & lymphoma 2024 Apr;65(4):472-480
Leukemia & lymphoma 2024 Apr;65(4):472-480
Immune characteristics associated with lymph node metastasis in early-stage NSCLC.
Zhang Z, Li L, Gao Y, Xiao X, Ji L, Zhou Z, Jiang J, Liu S, An J, Deng P, Du N, Li P, Xia X, Hu C, Li M
Cellular oncology (Dordrecht, Netherlands) 2024 Apr;47(2):447-461
Cellular oncology (Dordrecht, Netherlands) 2024 Apr;47(2):447-461
Tumor-activated IL-2 mRNA delivered by lipid nanoparticles for cancer immunotherapy.
Jiang Y, Zhang Y, Liu C, Liu J, Xue W, Wang Z, Li X
Journal of controlled release : official journal of the Controlled Release Society 2024 Apr;368:663-675
Journal of controlled release : official journal of the Controlled Release Society 2024 Apr;368:663-675
Metformin Alters Tumor Immune Microenvironment, Improving the Outcomes of Breast Cancer Patients With Type 2 Diabetes Mellitus.
Shiba S, Harao M, Saito A, Sakuragi M, Kitayama J, Sata N
Journal of breast cancer 2024 Apr;27(2):121-129
Journal of breast cancer 2024 Apr;27(2):121-129
Mn-Anti-CTLA4-CREKA-Sericin Nanotheragnostics for Enhanced Magnetic Resonance Imaging and Tumor Immunotherapy.
Huang Z, Wang Y, Su C, Li W, Wu M, Li W, Wu J, Xia Q, He H
Small (Weinheim an der Bergstrasse, Germany) 2024 Apr;20(15):e2306912
Small (Weinheim an der Bergstrasse, Germany) 2024 Apr;20(15):e2306912
Glycyrrhetinic acid inhibits non-small cell lung cancer via promotion of Prdx6- and caspase-3-mediated mitochondrial apoptosis.
Guo Q, Zhao M, Wang Q, Lu T, Luo P, Chen L, Xia F, Pang H, Shen S, Cheng G, Dai C, Meng Y, Zhong T, Qiu C, Wang J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Apr;173:116304
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Apr;173:116304
Hippo-signaling-controlled MHC class I antigen processing and presentation pathway potentiates antitumor immunity.
Peng L, Zhou L, Li H, Zhang X, Li S, Wang K, Yang M, Ma X, Zhang D, Xiang S, Duan Y, Wang T, Sun C, Wang C, Lu D, Qian M, Wang Z
Cell reports 2024 Apr 23;43(4):114003
Cell reports 2024 Apr 23;43(4):114003
Diaphorobacter nitroreducens synergize with oxaliplatin to reduce tumor burden in mice with lung adenocarcinoma.
Ni Y, Li R, Shen X, Yi D, Ren Y, Wang F, Geng Y, You Q
mSystems 2024 Apr 16;9(4):e0132323
mSystems 2024 Apr 16;9(4):e0132323
Scutellarin activates IDH1 to exert antitumor effects in hepatocellular carcinoma progression.
Cui Z, Li C, Liu W, Sun M, Deng S, Cao J, Yang H, Chen P
Cell death & disease 2024 Apr 15;15(4):267
Cell death & disease 2024 Apr 15;15(4):267
ISG15 is a potential therapeutic target for osteosarcoma: a comprehensive analysis based on bioinformatics and in vitro experiments.
Liao Y, Zhang X, Tang J, Hu F, Li D, Song H, Chen J, Guo J, Li R, Lin Y, Xie L
American journal of translational research 2023;15(2):817-833
American journal of translational research 2023;15(2):817-833
Tumor-secreted lactate contributes to an immunosuppressive microenvironment and affects CD8 T-cell infiltration in glioblastoma.
Wang Z, Dai Z, Zhang H, Liang X, Zhang X, Wen Z, Luo P, Zhang J, Liu Z, Zhang M, Cheng Q
Frontiers in immunology 2023;14:894853
Frontiers in immunology 2023;14:894853
FANCI serve as a prognostic biomarker correlated with immune infiltrates in skin cutaneous melanoma.
Cai Z, Duan Y, Li W, Liu Z, Gong Z, Hong S, He X, Xuanyuan X, Chen Y, Bi X, Wang W
Frontiers in immunology 2023;14:1295831
Frontiers in immunology 2023;14:1295831
A novel prognostic signatures based on metastasis- and immune-related gene pairs for colorectal cancer.
Pan B, Yue Y, Ding W, Sun L, Xu M, Wang S
Frontiers in immunology 2023;14:1161382
Frontiers in immunology 2023;14:1161382
PD-L1 and tumor-infiltrating CD8(+) lymphocytes are correlated with clinical characteristics in pediatric and adolescent pituitary adenomas.
Shi M, Song Y, Zhang Y, Li L, Yu J, Hou A, Han S
Frontiers in endocrinology 2023;14:1151714
Frontiers in endocrinology 2023;14:1151714
LRPPRC facilitates tumor progression and immune evasion through upregulation of m(6)A modification of PD-L1 mRNA in hepatocellular carcinoma.
Wang H, Tang A, Cui Y, Gong H, Li H
Frontiers in immunology 2023;14:1144774
Frontiers in immunology 2023;14:1144774
Protocadherin-1 serves as a prognostic biomarker and promotes pancreatic cancer progression by suppressing CD8(+) T cell infiltration through CCL5-CCR5 axis.
Jiang Z, Zhang S, Wang H, Hu C, Li L, Zheng X, Mu Y, Wang F, Mou Y, Liu M, Jin W
American journal of cancer research 2023;13(11):5197-5217
American journal of cancer research 2023;13(11):5197-5217
Establishment and validation of an immune infiltration predictive model for ovarian cancer.
Song Z, Zhang J, Sun Y, Jiang Z, Liu X
BMC medical genomics 2023 Sep 28;16(1):227
BMC medical genomics 2023 Sep 28;16(1):227
Single-cell and bulk sequencing analyses reveal the immune suppressive role of PTPN6 in glioblastoma.
Zhang X, Chen J, Zhang M, Liu S, Wang T, Wu T, Li B, Zhao S, Wang H, Li L, Wang C, Huang L
Aging 2023 Sep 21;15(18):9822-9841
Aging 2023 Sep 21;15(18):9822-9841
GPX3 is a key cholesterol-related gene associated with prognosis and tumor-infiltrating T cells in colorectal cancer.
Chen J, Wu Y, Zhou Q, Song Y, Zhuang J, Lu K, Yang X
Neoplasma 2023 Oct;70(5)
Neoplasma 2023 Oct;70(5)
Ki67-targeted oncolytic adenovirus expressing IL-15 improves intratumoral T cell infiltration and PD-L1 expression in glioblastoma.
Zhang Q, Zhang J, Tian Y, Wang J, Jin G, Liu F
Virology 2023 Oct;587:109885
Virology 2023 Oct;587:109885
METTL3 inhibition induced by M2 macrophage-derived extracellular vesicles drives anti-PD-1 therapy resistance via M6A-CD70-mediated immune suppression in thyroid cancer.
Ning J, Hou X, Hao J, Zhang W, Shi Y, Huang Y, Ruan X, Zheng X, Gao M
Cell death and differentiation 2023 Oct;30(10):2265-2279
Cell death and differentiation 2023 Oct;30(10):2265-2279
Targeting TNFAIP2 induces immunogenic cell death and sensitizes glioblastoma multiforme to anti-PD-1 therapy.
Hou C, Shi S, Gao M, Ji J, Ma C, Wang T, Chen T, Liu Y, Zhong J, Zheng Y, Ye J, Ke Y
Journal of neuro-oncology 2023 Oct;165(1):79-90
Journal of neuro-oncology 2023 Oct;165(1):79-90
A Booster for Radiofrequency Ablation: Advanced Adjuvant Therapy via In Situ Nanovaccine Synergized with Anti-programmed Death Ligand 1 Immunotherapy for Systemically Constraining Hepatocellular Carcinoma.
Tian Z, Hu Q, Sun Z, Wang N, He H, Tang Z, Chen W
ACS nano 2023 Oct 10;17(19):19441-19458
ACS nano 2023 Oct 10;17(19):19441-19458
Deubiquitinase inhibitor PR-619 potentiates colon cancer immunotherapy by inducing ferroptosis.
Wu J, Liu C, Wang T, Liu H, Wei B
Immunology 2023 Nov;170(3):439-451
Immunology 2023 Nov;170(3):439-451
Mesothelin-targeted CAR-T therapy combined with irinotecan for the treatment of solid cancer.
Zhu Y, Zuo D, Wang K, Lan S, He H, Chen L, Chen X, Feng M
Journal of cancer research and clinical oncology 2023 Nov;149(16):15027-15038
Journal of cancer research and clinical oncology 2023 Nov;149(16):15027-15038
Engineering high-affinity dual targeting cellular nanovesicles for optimised cancer immunotherapy.
Zhang L, Zhao X, Niu Y, Ma X, Yuan W, Ma J
Journal of extracellular vesicles 2023 Nov;12(11):e12379
Journal of extracellular vesicles 2023 Nov;12(11):e12379
Low-dose radiotherapy combined with dual PD-L1 and VEGFA blockade elicits antitumor response in hepatocellular carcinoma mediated by activated intratumoral CD8(+) exhausted-like T cells.
Li S, Li K, Wang K, Yu H, Wang X, Shi M, Liang Z, Yang Z, Hu Y, Li Y, Liu W, Li H, Cheng S, Ye L, Yang Y
Nature communications 2023 Nov 24;14(1):7709
Nature communications 2023 Nov 24;14(1):7709
TWEAK and Fn14 are overexpressed in immune-mediated necrotizing myopathy: implications for muscle damage and repair.
Yang M, Ge H, Ji S, Li Y, Xu L, Bi Z, Bu B
Rheumatology (Oxford, England) 2023 Nov 2;62(11):3732-3741
Rheumatology (Oxford, England) 2023 Nov 2;62(11):3732-3741
FAM171B stabilizes vimentin and enhances CCL2-mediated TAM infiltration to promote bladder cancer progression.
Hu WM, Li M, Ning JZ, Tang YQ, Song TB, Li LZ, Zou F, Cheng F, Yu WM
Journal of experimental & clinical cancer research : CR 2023 Nov 2;42(1):290
Journal of experimental & clinical cancer research : CR 2023 Nov 2;42(1):290
Combination of novel oncolytic herpesvirus with paclitaxel as an efficient strategy for breast cancer therapy.
Deng X, Shen Y, Yi M, Zhang C, Zhao B, Zhong G, WeiyangLou, Xue D, Leng Q, Ding J, Zhao R, Jia W, Dong C, Dai Z
Journal of medical virology 2023 May;95(5):e28768
Journal of medical virology 2023 May;95(5):e28768
Exploration of (68)Ga-labelled prostate-specific membrane antigen-11 PET/CT parameters for identifying PBRM1 status in primary clear cell renal cell carcinoma.
Wang B, Deng Y, Xu Q, Gao J, Shen H, He X, Ding Q, Wang F, Guo H
Clinical radiology 2023 May;78(5):e417-e424
Clinical radiology 2023 May;78(5):e417-e424
Exosomal PD‑L1 promotes the formation of an immunosuppressive microenvironment in gastric diffuse large B‑cell lymphoma.
Zeng H, Wang J, Xu B, Deng H, Peng M, Deng R, Shang S, Hu Q, Li J, Lin J, Zhu H, Li Y, Zuo C
Oncology reports 2023 May;49(5)
Oncology reports 2023 May;49(5)
High baseline tumor burden-associated macrophages promote an immunosuppressive microenvironment and reduce the efficacy of immune checkpoint inhibitors through the IGFBP2-STAT3-PD-L1 pathway.
Wen Z, Sun H, Zhang Z, Zheng Y, Zheng S, Bin J, Liao Y, Shi M, Zhou R, Liao W
Cancer communications (London, England) 2023 May;43(5):562-581
Cancer communications (London, England) 2023 May;43(5):562-581
Prognostic value of CD8-to-EGFR ratio in salivary microvesicles of patients with oral squamous cell carcinoma.
Man QW, Li RF, Zhong NN, Liu B
Oral diseases 2023 May;29(4):1480-1486
Oral diseases 2023 May;29(4):1480-1486
GBP2 promotes clear cell renal cell carcinoma progression through immune infiltration and regulation of PD‑L1 expression via STAT1 signaling.
Ye S, Li S, Qin L, Zheng W, Liu B, Li X, Ren Z, Zhao H, Hu X, Ye N, Li G
Oncology reports 2023 Mar;49(3)
Oncology reports 2023 Mar;49(3)
Oncogenic epidermal growth factor receptor signal-induced histone deacetylation suppresses chemokine gene expression in human lung adenocarcinoma.
Sumimoto H, Takano A, Igarashi T, Hanaoka J, Teramoto K, Daigo Y
Scientific reports 2023 Mar 29;13(1):5087
Scientific reports 2023 Mar 29;13(1):5087
Anti-signal recognition particle positive necrotizing myopathy-sjogren's syndrome overlap syndrome: a descriptive study on clinical and myopathology features.
Xu L, Yang MG, Hu L, Gao H, Ji S
BMC musculoskeletal disorders 2023 Mar 23;24(1):219
BMC musculoskeletal disorders 2023 Mar 23;24(1):219
PYCR1 promotes the malignant progression of lung cancer through the JAK-STAT3 signaling pathway via PRODH-dependent glutamine synthesize.
Zhang L, Zhao X, Wang E, Yang Y, Hu L, Xu H, Zhang B
Translational oncology 2023 Jun;32:101667
Translational oncology 2023 Jun;32:101667
An integrated bioinformatic investigation of focal adhesion-related genes in glioma followed by preliminary validation of COL1A2 in tumorigenesis.
Yao G, Deng L, Long X, Zhou Y, Zhou X
Aging 2023 Jun 22;15(13):6225-6254
Aging 2023 Jun 22;15(13):6225-6254
Optogenetic engineered umbilical cord MSC-derived exosomes for remodeling of the immune microenvironment in diabetic wounds and the promotion of tissue repair.
Zhao X, Fu L, Zou H, He Y, Pan Y, Ye L, Huang Y, Fan W, Zhang J, Ma Y, Chen J, Zhu M, Zhang C, Cai Y, Mou X
Journal of nanobiotechnology 2023 Jun 2;21(1):176
Journal of nanobiotechnology 2023 Jun 2;21(1):176
STAT4, a potential predictor of prognosis, promotes CD8 T‑cell infiltration in ovarian serous carcinoma by inducing CCL5 secretion.
Wang W, Liu S, Lu F, Yang B, Zhuang X, Yin J, Chen G, Sun C
Oncology reports 2023 Jul;50(1)
Oncology reports 2023 Jul;50(1)
An inflammation-associated ferroptosis signature optimizes the diagnosis, prognosis evaluation and immunotherapy options in hepatocellular carcinoma.
Ruan WY, Zhang L, Lei S, Zeng ZR, Yang YS, Cao WP, Hao QY, Lu M, Tian XB, Peng PL
Journal of cellular and molecular medicine 2023 Jul;27(13):1820-1835
Journal of cellular and molecular medicine 2023 Jul;27(13):1820-1835
Inhibition of FGFR3 upregulates MHC-I and PD-L1 via TLR3/NF-kB pathway in muscle-invasive bladder cancer.
Wu W, Chen L, Jia G, Tang Q, Han B, Xia S, Jiang Q, Liu H
Cancer medicine 2023 Jul;12(14):15676-15690
Cancer medicine 2023 Jul;12(14):15676-15690
Intra-tumoral infiltration of adipocyte facilitates the activation of antitumor immune response in pancreatic ductal adenocarcinoma.
Liu X, Liu J, Xu J, Zhang B, Wei M, Li J, Xu H, Yu X, Wang W, Shi S
Translational oncology 2023 Jan;27:101561
Translational oncology 2023 Jan;27:101561
Virulence factors and mechanisms of paediatric pneumonia caused by Enterococcus faecalis.
Tian Z, Khan AI, Rehman AU, Deng T, Ma C, Wang L
Gut pathogens 2023 Jan 9;15(1):2
Gut pathogens 2023 Jan 9;15(1):2
Inhibition of Checkpoint Kinase 1 (CHK1) Upregulates Interferon Regulatory Factor 1 (IRF1) to Promote Apoptosis and Activate Anti-Tumor Immunity via MICA in Hepatocellular Carcinoma (HCC).
Li X, Huang J, Wu Q, Du Q, Wang Y, Huang Y, Cai X, Geller DA, Yan Y
Cancers 2023 Jan 30;15(3)
Cancers 2023 Jan 30;15(3)
Expression of glucose transporter-1 in follicular lymphoma affected tumor-infiltrating immunocytes and was related to progression of disease within 24 months.
Deng Y, Ma J, Zhao S, Yang M, Sun Y, Zhang Q
Translational oncology 2023 Feb;28:101614
Translational oncology 2023 Feb;28:101614
The PD-L1 Expression and Tumor-Infiltrating Immune Cells Predict an Unfavorable Prognosis in Pancreatic Ductal Adenocarcinoma and Adenosquamous Carcinoma.
Zhang Z, Xiong Q, Xu Y, Cai X, Zhang L, Zhu Q
Journal of clinical medicine 2023 Feb 9;12(4)
Journal of clinical medicine 2023 Feb 9;12(4)
HNRNPL induced circFAM13B increased bladder cancer immunotherapy sensitivity via inhibiting glycolysis through IGF2BP1/PKM2 pathway.
Lv J, Li K, Yu H, Han J, Zhuang J, Yu R, Cheng Y, Song Q, Bai K, Cao Q, Yang H, Yang X, Lu Q
Journal of experimental & clinical cancer research : CR 2023 Feb 6;42(1):41
Journal of experimental & clinical cancer research : CR 2023 Feb 6;42(1):41
HRS Regulates Small Extracellular Vesicle PD-L1 Secretion and Is Associated with Anti-PD-1 Treatment Efficacy.
Xiao BL, Wang XL, Xia HF, Zhang LZ, Wang KM, Chen ZK, Zhong YH, Jiang HG, Zhou FX, Wang W, Chen GL, Chen G
Cancer immunology research 2023 Feb 3;11(2):228-240
Cancer immunology research 2023 Feb 3;11(2):228-240
Apoptotic tumor cell-derived microparticles loading Napabucasin inhibit CSCs and synergistic immune therapy.
Jing B, Guo F, An R, Gao Y, Li Y, Xie Y, Wang J, Chen Y, Li H, Gao T, Jin Q, Zhang L, Xie M
Journal of nanobiotechnology 2023 Feb 2;21(1):37
Journal of nanobiotechnology 2023 Feb 2;21(1):37
Proteomic and single-cell landscape reveals novel pathogenic mechanisms of HBV-infected intrahepatic cholangiocarcinoma.
Shen Y, Xu S, Ye C, Li Q, Chen R, Wu W, Jiang Q, Jia Y, Zhang X, Fan L, Fu W, Jiang M, Chen J, Timko MP, Zhao P, Ruan J
iScience 2023 Feb 17;26(2):106003
iScience 2023 Feb 17;26(2):106003
Behind the Indolent Facade: Uncovering the Molecular Features and Malignancy Potential in Lung Minimally Invasive Adenocarcinoma by Single-Cell Transcriptomics.
Zhang X, Liang B, Huang Y, Meng H, Li Z, Du J, Zhou L, Zhong Y, Wang B, Lin X, Yu G, Chen X, Lu W, Chen ZS, Yang X, Huang Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Dec;10(36):e2303753
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Dec;10(36):e2303753
Metformin may improve the outcome of patients with colorectal cancer and type 2 diabetes mellitus partly through effects on neutrophil extracellular traps.
Saito A, Koinuma K, Kawashima R, Miyato H, Ohzawa H, Horie H, Yamaguchi H, Kawahira H, Mimura T, Kitayama J, Sata N
BJC reports 2023 Dec 12;1(1):20
BJC reports 2023 Dec 12;1(1):20
Single-cell transcriptome sequencing of B-cell heterogeneity and tertiary lymphoid structure predicts breast cancer prognosis and neoadjuvant therapy efficacy.
Wang Q, Sun K, Liu R, Song Y, Lv Y, Bi P, Yang F, Li S, Zhao J, Li X, Chen D, Mei J, Yang R, Chen K, Liu D, Tang S
Clinical and translational medicine 2023 Aug;13(8):e1346
Clinical and translational medicine 2023 Aug;13(8):e1346
PPARγ agonist inhibits c-Myc-mediated colorectal cancer tumor immune escape.
Xu L, Che S, Chen H, Liu Q, Shi J, Jin J, Hou Y
Journal of cellular biochemistry 2023 Aug;124(8):1145-1154
Journal of cellular biochemistry 2023 Aug;124(8):1145-1154
Zerumbone attenuates the excessive proliferation of keratinocytes in psoriasis mice through regulating NLRP3/NF-κB pathway.
Lin J, Fang Y, Cao Y, Ma L, Tao M, Wang X, Li Y, Qing L
Toxicology research 2023 Aug;12(4):658-664
Toxicology research 2023 Aug;12(4):658-664
Single cell transcriptomic analyses implicate an immunosuppressive tumor microenvironment in pancreatic cancer liver metastasis.
Zhang S, Fang W, Zhou S, Zhu D, Chen R, Gao X, Li Z, Fu Y, Zhang Y, Yang F, Zhao J, Wu H, Wang P, Shen Y, Shen S, Xu G, Wang L, Yan C, Zou X, Chen D, Lv Y
Nature communications 2023 Aug 23;14(1):5123
Nature communications 2023 Aug 23;14(1):5123
Single-cell dissection of cervical cancer reveals key subsets of the tumor immune microenvironment.
Cao G, Yue J, Ruan Y, Han Y, Zhi Y, Lu J, Liu M, Xu X, Wang J, Gu Q, Wen X, Gao J, Zhang Q, Kang J, Wang C, Li F
The EMBO journal 2023 Aug 15;42(16):e110757
The EMBO journal 2023 Aug 15;42(16):e110757
CT-based radiomics signature to predict CD8+ tumor infiltrating lymphocytes in non-small-cell lung cancer.
Chen Y, Xu T, Jiang C, You S, Cheng Z, Gong J
Acta radiologica (Stockholm, Sweden : 1987) 2023 Apr;64(4):1390-1399
Acta radiologica (Stockholm, Sweden : 1987) 2023 Apr;64(4):1390-1399
Regulation of CD8(+) T cells infiltration and immunotherapy by circMGA/HNRNPL complex in bladder cancer.
Sun J, Zhang H, Wei W, Xiao X, Huang C, Wang L, Zhong H, Jiang Y, Zheng F, Yang H, Jiang G, Zhang X
Oncogene 2023 Apr;42(15):1247-1262
Oncogene 2023 Apr;42(15):1247-1262
MAX transcriptionally enhances PD-L1 to inhibit CD8+ T cell-mediated killing of lung adenocarcinoma cells.
Huang D, Wang X, Qian Y, Wu J, Chen B, Zhang D, Dong F, Li Y
Cellular immunology 2023 Apr;386:104706
Cellular immunology 2023 Apr;386:104706
Characterization of myeloid signature genes for predicting prognosis and immune landscape in Ewing sarcoma.
Zhang Z, Shi Y, Zhu Z, Fu J, Liu D, Liu X, Dang J, Tao H, Fan H
Cancer science 2023 Apr;114(4):1240-1255
Cancer science 2023 Apr;114(4):1240-1255
Self-Assembly Catalase Nanocomplex Conveyed by Bacterial Vesicles for Oxygenated Photodynamic Therapy and Tumor Immunotherapy.
Zhang J, Li Z, Liu L, Li L, Zhang L, Wang Y, Zhao J
International journal of nanomedicine 2022;17:1971-1985
International journal of nanomedicine 2022;17:1971-1985
CLEC1B is a Promising Prognostic Biomarker and Correlated with Immune Infiltration in Hepatocellular Carcinoma.
Liang X, Song F, Fang W, Zhang Y, Feng Z, Chen Z, Han L, Chen Z
International journal of general medicine 2022;15:5661-5672
International journal of general medicine 2022;15:5661-5672
A Comparison for Type 2 Cytokines and Lesional Inflammatory Infiltrations in Bullous Pemphigoid and Atopic Dermatitis.
Hu YQ, Zhang JZ
Clinical, cosmetic and investigational dermatology 2022;15:2313-2321
Clinical, cosmetic and investigational dermatology 2022;15:2313-2321
Identification of a novel immune gene panel in tongue squamous cell carcinoma.
Sun J, Guo F, Tang Q, Chen G, Peng J, Shen Y, Zhang J, Hu J, Yang C
American journal of translational research 2022;14(5):2801-2824
American journal of translational research 2022;14(5):2801-2824
Single-cell sequencing reveals effects of chemotherapy on the immune landscape and TCR/BCR clonal expansion in a relapsed ovarian cancer patient.
Ren Y, Li R, Feng H, Xie J, Gao L, Chu S, Li Y, Meng F, Ning Y
Frontiers in immunology 2022;13:985187
Frontiers in immunology 2022;13:985187
Identification of ST3GAL5 as a prognostic biomarker correlating with CD8(+) T cell exhaustion in clear cell renal cell carcinoma.
Liu J, Li M, Wu J, Qi Q, Li Y, Wang S, Liang S, Zhang Y, Zhu Z, Huang R, Yan J, Zhu R
Frontiers in immunology 2022;13:979605
Frontiers in immunology 2022;13:979605
CEP192 is a novel prognostic marker and correlates with the immune microenvironment in hepatocellular carcinoma.
Liu Y, Liang W, Chang Y, He Z, Wu M, Zheng H, Ke X, Lv M, Liu Q, Liu Q, Tang W, Huang Q, Lu Y, He M, Yang Q, Mo C, Wang J, Peng K, Min Z, Su H, Chen J
Frontiers in immunology 2022;13:950884
Frontiers in immunology 2022;13:950884
A Study on the Radiosensitivity of Radiation-Induced Lung Injury at the Acute Phase Based on Single-Cell Transcriptomics.
Ma L, Ye Y, Lu H, Xing Y, Zhao Z, Quan C, Jia Z, Lu Y, Li Y, Zhou G
Frontiers in immunology 2022;13:941976
Frontiers in immunology 2022;13:941976
Single-cell RNA sequencing reveals distinct immunology profiles in human keloid.
Feng C, Shan M, Xia Y, Zheng Z, He K, Wei Y, Song K, Meng T, Liu H, Hao Y, Liang Z, Wang Y, Huang Y
Frontiers in immunology 2022;13:940645
Frontiers in immunology 2022;13:940645
Identify the immune characteristics and immunotherapy value of CD93 in the pan-cancer based on the public data sets.
Guo A, Zhang J, Tian Y, Peng Y, Luo P, Zhang J, Liu Z, Wu W, Zhang H, Cheng Q
Frontiers in immunology 2022;13:907182
Frontiers in immunology 2022;13:907182
Transmembrane Protein 170B is a Prognostic Biomarker and Associated With Immune Infiltrates in Pancreatic Adenocarcinoma.
Zhang Z, Shang J, Dai Z, Yao Y, Shi Y, Zhong D, Liang Y, Lai C, Yang Q, Feng T, Huang X
Frontiers in genetics 2022;13:848391
Frontiers in genetics 2022;13:848391
A Pan-Cancer Analysis Reveals CLEC5A as a Biomarker for Cancer Immunity and Prognosis.
Chen R, Wu W, Chen SY, Liu ZZ, Wen ZP, Yu J, Zhang LB, Liu Z, Zhang J, Luo P, Zeng WJ, Cheng Q
Frontiers in immunology 2022;13:831542
Frontiers in immunology 2022;13:831542
A novel ganglioside-related risk signature can reveal the distinct immune landscape of neuroblastoma and predict the immunotherapeutic response.
Yang J, Han L, Sha Y, Jin Y, Li Z, Gong B, Li J, Liu Y, Wang Y, Zhao Q
Frontiers in immunology 2022;13:1061814
Frontiers in immunology 2022;13:1061814
Identification and experimental validation of a tumor-infiltrating lymphocytes-related long noncoding RNA signature for prognosis of clear cell renal cell carcinoma.
Deng Y, Guo K, Tang Z, Feng Y, Cai S, Ye J, Xi Y, Li J, Liu R, Cai C, Tan Z, Zhang Y, Han Z, Zeng G, Zhong W
Frontiers in immunology 2022;13:1046790
Frontiers in immunology 2022;13:1046790
A pan-cancer and single-cell sequencing analysis of CD161, a promising onco-immunological biomarker in tumor microenvironment and immunotherapy.
Li H, Zhou K, Wang K, Cao H, Wu W, Wang Z, Dai Z, Chen S, Peng Y, Xiao G, Luo P, Zhang J, Liu Z, Cheng Q, Zhang H
Frontiers in immunology 2022;13:1040289
Frontiers in immunology 2022;13:1040289
A specific immune signature for predicting the prognosis of glioma patients with IDH1-mutation and guiding immune checkpoint blockade therapy.
Zeng Z, Hu C, Ruan W, Zhang J, Lei S, Yang Y, Peng P, Pan F, Chen T
Frontiers in immunology 2022;13:1001381
Frontiers in immunology 2022;13:1001381
Machine learning-based identification of tumor-infiltrating immune cell-associated lncRNAs for improving outcomes and immunotherapy responses in patients with low-grade glioma.
Zhang N, Zhang H, Wu W, Zhou R, Li S, Wang Z, Dai Z, Zhang L, Liu F, Liu Z, Zhang J, Luo P, Liu Z, Cheng Q
Theranostics 2022;12(13):5931-5948
Theranostics 2022;12(13):5931-5948
Label-free LC-MS/MS proteomics analyses reveal CLIC1 as a predictive biomarker for bladder cancer staging and prognosis.
Wang W, Huang G, Lin H, Ren L, Fu L, Mao X
Frontiers in oncology 2022;12:1102392
Frontiers in oncology 2022;12:1102392
Screening of an individualized treatment strategy for an advanced gallbladder cancer using patient-derived tumor xenograft and organoid models.
Tan D, An J, Gong M, Wang H, Li H, Meng H, Zhang C, Zhao Y, Ge X, Shi C
Frontiers in oncology 2022;12:1043479
Frontiers in oncology 2022;12:1043479
Oncolytic adenovirus with MUC16-BiTE shows enhanced antitumor immune response by reversing the tumor microenvironment in PDX model of ovarian cancer.
Wang Q, Ma X, Wu H, Zhao C, Chen J, Li R, Yan S, Li Y, Zhang Q, Song K, Yuan C, Kong B
Oncoimmunology 2022;11(1):2096362
Oncoimmunology 2022;11(1):2096362
Identify the Prognostic and Immune Profile of VSIR in the Tumor Microenvironment: A Pan-Cancer Analysis.
Liu Y, Zhang J, Wang Z, Zhang X, Dai Z, Wu W, Zhang N, Liu Z, Zhang J, Luo P, Wen Z, Yu J, Zhang H, Yang T, Cheng Q
Frontiers in cell and developmental biology 2022;10:821649
Frontiers in cell and developmental biology 2022;10:821649
Immunohistochemical analysis of PD-L1 and tumor-infiltrating immune cells expression in the tumor microenvironment of primary signet ring cell carcinoma of the prostate.
Teng QL, Yang XR, Wen S, Dai ZH, Wang HL, Liu TQ, Wang L, Fan B, Liu ZY
Asian journal of andrology 2022 Sep-Oct;24(5):525-532
Asian journal of andrology 2022 Sep-Oct;24(5):525-532
Sphingosine kinase 1 promotes tumor immune evasion by regulating the MTA3-PD-L1 axis.
Lau P, Zhang G, Zhao S, Liang L, Zhang H, Zhou G, Hung MC, Chen X, Liu H
Cellular & molecular immunology 2022 Oct;19(10):1153-1167
Cellular & molecular immunology 2022 Oct;19(10):1153-1167
miR-126 downregulates CXCL12 expression in intestinal epithelial cells to suppress the recruitment and function of macrophages and tumorigenesis in a murine model of colitis-associated colorectal cancer.
Wu S, Yuan W, Luo W, Nie K, Wu X, Meng X, Shen Z, Wang X
Molecular oncology 2022 Oct;16(19):3465-3489
Molecular oncology 2022 Oct;16(19):3465-3489
Tannins in Terminalia bellirica inhibits hepatocellular carcinoma growth via re-educating tumor-associated macrophages and restoring CD8(+)T cell function.
Chang Z, Zhang Q, Hu Q, Liu Y, Zhang L, Liu R
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Oct;154:113543
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Oct;154:113543
An improved cell line-derived xenograft humanized mouse model for evaluation of PD-1/PD-L1 blocker BMS202-induced immune responses in colorectal cancer.
Shang P, Yu L, Cao S, Guo C, Zhang W
Acta biochimica et biophysica Sinica 2022 Oct 25;54(10):1497-1506
Acta biochimica et biophysica Sinica 2022 Oct 25;54(10):1497-1506
Si-Wu-Tang ameliorates bile duct ligation-induced liver fibrosis via modulating immune environment.
Ma Z, Xue X, Bai J, Cai Y, Jin X, Jia K, Ding M, Lyu X, Li X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Nov;155:113834
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Nov;155:113834
Machine learning-based tumor-infiltrating immune cell-associated lncRNAs for predicting prognosis and immunotherapy response in patients with glioblastoma.
Zhang H, Zhang N, Wu W, Zhou R, Li S, Wang Z, Dai Z, Zhang L, Liu Z, Zhang J, Luo P, Liu Z, Cheng Q
Briefings in bioinformatics 2022 Nov 19;23(6)
Briefings in bioinformatics 2022 Nov 19;23(6)
Identification of CD73 as a Novel Biomarker Encompassing the Tumor Microenvironment, Prognosis, and Therapeutic Responses in Various Cancers.
Tang K, Zhang J, Cao H, Xiao G, Wang Z, Zhang X, Zhang N, Wu W, Zhang H, Wang Q, Xu H, Cheng Q
Cancers 2022 Nov 17;14(22)
Cancers 2022 Nov 17;14(22)
Programmed death ligand 1 and tumor-infiltrating CD8(+) T lymphocytes are associated with the clinical features in meningioma.
Zhang Y, Wang X, Shi M, Song Y, Yu J, Han S
BMC cancer 2022 Nov 12;22(1):1171
BMC cancer 2022 Nov 12;22(1):1171
LRRC8A Is a Promising Prognostic Biomarker and Therapeutic Target for Pancreatic Adenocarcinoma.
Xu R, Hu Y, Xie Q, Zhang C, Zhao Y, Zhang H, Shi H, Wang X, Shi C
Cancers 2022 Nov 10;14(22)
Cancers 2022 Nov 10;14(22)
CD4(+) T cells are required to improve the efficacy of CIK therapy in non-small cell lung cancer.
Liu S, Meng Y, Liu L, Lv Y, Yu W, Liu T, Wang L, Mu D, Zhou Q, Liu M, Ren Y, Zhang D, Li B, Sun Q, Ren X
Cell death & disease 2022 May 6;13(5):441
Cell death & disease 2022 May 6;13(5):441
The Immunological Contribution of a Novel Metabolism-Related Signature to the Prognosis and Anti-Tumor Immunity in Cervical Cancer.
Yu S, Li X, Ma M, Yang R, Zhang J, Wu S
Cancers 2022 May 13;14(10)
Cancers 2022 May 13;14(10)
Single-cell transcriptomics links malignant T cells to the tumor immune landscape in cutaneous T cell lymphoma.
Liu X, Jin S, Hu S, Li R, Pan H, Liu Y, Lai P, Xu D, Sun J, Liu Z, Gao Y, Zhao Y, Liu F, Xiao Y, Li Y, Wen Y, Chen Z, Xu B, Lin Y, Ran M, Li Q, Yang S, Li H, Tu P, Haniffa M, Teichmann SA, Bai F, Wang Y
Nature communications 2022 Mar 3;13(1):1158
Nature communications 2022 Mar 3;13(1):1158
Polymeric indoximod based prodrug nanoparticles with doxorubicin entrapment for inducing immunogenic cell death and improving the immunotherapy of breast cancer.
Zang X, Song J, Yi X, Piyu J
Journal of materials chemistry. B 2022 Mar 23;10(12):2019-2027
Journal of materials chemistry. B 2022 Mar 23;10(12):2019-2027
Photosynthetic microorganisms coupled photodynamic therapy for enhanced antitumor immune effect.
Wang H, Liu H, Guo Y, Zai W, Li X, Xiong W, Zhao X, Yao Y, Hu Y, Zou Z, Wu J
Bioactive materials 2022 Jun;12:97-106
Bioactive materials 2022 Jun;12:97-106
The impact of neoadjuvant chemotherapy on the tumor microenvironment in advanced high-grade serous carcinoma.
Shen Y, Ren Y, Chen K, Cen Y, Zhang B, Lu W, Xu J
Oncogenesis 2022 Jul 30;11(1):43
Oncogenesis 2022 Jul 30;11(1):43
CMTM6: increased circulating level and up-regulated expression in labial salivary glands in patients with primary Sjogren's syndrome.
Qian S, Xu J, Zhao S, Yang P, Yang C
Clinical and experimental immunology 2022 Jan 28;207(1):65-71
Clinical and experimental immunology 2022 Jan 28;207(1):65-71
Remodeling Chondroitin-6-Sulfate-Mediated Immune Exclusion Enhances Anti-PD-1 Response in Colorectal Cancer with Microsatellite Stability.
Wu Q, Huang Q, Jiang Y, Sun F, Liang B, Wang J, Hu X, Sun M, Ma Z, Shi Y, Liang Y, Tan Y, Zeng D, Yao F, Xu X, Yao Z, Li S, Rong X, Huang N, Sun L, Liao W, Shi M
Cancer immunology research 2022 Feb;10(2):182-199
Cancer immunology research 2022 Feb;10(2):182-199
Salivary non-apoptotic tumoral microvesicles: A potential progressive marker in oral cancer patients.
Man QW, Li RF, Bu LL, Zhao Y, Liu B
Journal of cellular and molecular medicine 2022 Dec;26(24):5955-5965
Journal of cellular and molecular medicine 2022 Dec;26(24):5955-5965
Interleukin-10 induces expression of CD39 on CD8+T cells to potentiate anti-PD1 efficacy in EGFR-mutated non-small cell lung cancer.
Qiao M, Zhou F, Liu X, Jiang T, Wang H, Jia Y, Li X, Zhao C, Cheng L, Chen X, Ren S, Liu H, Zhou C
Journal for immunotherapy of cancer 2022 Dec;10(12)
Journal for immunotherapy of cancer 2022 Dec;10(12)
SPI1 is a prognostic biomarker of immune infiltration and immunotherapy efficacy in clear cell renal cell carcinoma.
Feng H, Wang T, Ye J, Yang Y, Huang X, Lai D, Lv Z, Huang Y, Zhang X
Discover oncology 2022 Dec 7;13(1):134
Discover oncology 2022 Dec 7;13(1):134
Association of MARCH7 with tumor progression and T-cell infiltration in esophageal cancer.
Singh S, Bano A, Saraya A, Das P, Sharma R
Medical oncology (Northwood, London, England) 2022 Dec 30;40(1):67
Medical oncology (Northwood, London, England) 2022 Dec 30;40(1):67
Neuropilin-1 is a valuable biomarker for predicting response of advanced non-small cell lung cancer patients to hypofractionated radiotherapy and PD-1 blockade.
Kang P, Li Y, Hu Z, Lei M, Cheng J, Guo X, Zhang L, Lin S, Yuan Q
International immunopharmacology 2022 Aug;109:108732
International immunopharmacology 2022 Aug;109:108732
Downregulation of PD-L1 and HLA-I in non-small cell lung cancer with ALK fusion.
Mu D, Guo J, Yu W, Zhang J, Ren X, Han Y
Thoracic cancer 2022 Apr;13(8):1153-1163
Thoracic cancer 2022 Apr;13(8):1153-1163
SIGLEC15 amplifies immunosuppressive properties of tumor-associated macrophages in pancreatic cancer.
Li TJ, Jin KZ, Li H, Ye LY, Li PC, Jiang B, Lin X, Liao ZY, Zhang HR, Shi SM, Lin MX, Fei QL, Xiao ZW, Xu HX, Liu L, Yu XJ, Wu WD
Cancer letters 2022 Apr 1;530:142-155
Cancer letters 2022 Apr 1;530:142-155
Paraspeckle Promotes Hepatocellular Carcinoma Immune Escape by Sequestering IFNGR1 mRNA.
Zan J, Zhao X, Deng X, Ding H, Wang B, Lu M, Wei Z, Huang Z, Wang S
Cellular and molecular gastroenterology and hepatology 2021;12(2):465-487
Cellular and molecular gastroenterology and hepatology 2021;12(2):465-487
ACSL4 Expression Is Associated With CD8+ T Cell Infiltration and Immune Response in Bladder Cancer.
Luo W, Wang J, Dai X, Zhang H, Qu Y, Xiao W, Ye D, Zhu Y
Frontiers in oncology 2021;11:754845
Frontiers in oncology 2021;11:754845
A Novel Strategy Conjugating PD-L1 Polypeptide With Doxorubicin Alleviates Chemotherapeutic Resistance and Enhances Immune Response in Colon Cancer.
Wang M, Shu XS, Li M, Zhang Y, Yao Y, Huang X, Li J, Wei P, He Z, Lu J, Ying Y
Frontiers in oncology 2021;11:737323
Frontiers in oncology 2021;11:737323
Clinical Relevance and Prognostic Value of the Neuronal Protein Neuroligin 2 in Breast Cancer.
Zhang G, Sun Y, Wu ZS, Huang X
Frontiers in oncology 2021;11:630257
Frontiers in oncology 2021;11:630257
Development of bispecific anti-c-Met/PD-1 diabodies for the treatment of solid tumors and the effect of c-Met binding affinity on efficacy.
Yuan Q, Liang Q, Sun Z, Yuan X, Hou W, Wang Y, Wang H, Yu M
Oncoimmunology 2021;10(1):1914954
Oncoimmunology 2021;10(1):1914954
Injectable shear-thinning polylysine hydrogels for localized immunotherapy of gastric cancer through repolarization of tumor-associated macrophages.
Yang Y, Yang Y, Chen M, Chen J, Wang J, Ma Y, Qian H
Biomaterials science 2021 Sep 28;9(19):6597-6608
Biomaterials science 2021 Sep 28;9(19):6597-6608
Hyperbaric oxygen treatment on keloid tumor immune gene expression.
Wang CH, Shan MJ, Liu H, Hao Y, Song KX, Wu HW, Meng T, Feng C, Qi Z, Wang Z, Wang YB
Chinese medical journal 2021 Sep 13;134(18):2205-2213
Chinese medical journal 2021 Sep 13;134(18):2205-2213
Cancer-cell-biomimetic Upconversion nanoparticles combining chemo-photodynamic therapy and CD73 blockade for metastatic triple-negative breast cancer.
Jin F, Qi J, Liu D, You Y, Shu G, Du Y, Wang J, Xu X, Ying X, Ji J, Du Y
Journal of controlled release : official journal of the Controlled Release Society 2021 Sep 10;337:90-104
Journal of controlled release : official journal of the Controlled Release Society 2021 Sep 10;337:90-104
A novel mechanism of lung cancer inhibition by methionine enkephalin through remodeling the immune status of the tumor microenvironment.
Zhang S, Huang H, Handley M, Griffin N, Bai X, Shan F
International immunopharmacology 2021 Oct;99:107999
International immunopharmacology 2021 Oct;99:107999
CMTM6 expression in M2 macrophages is a potential predictor of PD-1/PD-L1 inhibitor response in colorectal cancer.
Wu X, Lan X, Hu W, Zhang W, Lai X, Xu S, Li J, Qiu W, Wang W, Xiao J, Wang F, Ding Y, Liang L
Cancer immunology, immunotherapy : CII 2021 Nov;70(11):3235-3248
Cancer immunology, immunotherapy : CII 2021 Nov;70(11):3235-3248
Dipeptidyl Peptidase (DPP)-4 Inhibitor Impairs the Outcomes of Patients with Type 2 Diabetes Mellitus After Curative Resection for Colorectal Cancer.
Saito A, Kitayama J, Horie H, Koinuma K, Kawashima R, Ohzawa H, Yamaguchi H, Kawahira H, Mimura T, Lefor AK, Sata N
Cancer research communications 2021 Nov;1(2):106-114
Cancer research communications 2021 Nov;1(2):106-114
A multi-effective and long-acting immunotherapy through one single hydrogel based injection.
Wang M, Cheng X, Luo L, Liu Y, Cao F, Zhao S, Peng H, Hong C, Jin L, Deng L, Xin H, Wang X
Biomaterials science 2021 Feb 21;9(4):1374-1380
Biomaterials science 2021 Feb 21;9(4):1374-1380
The impact of tobacco exposure on tumor microenvironment and prognosis in lung adenocarcinoma by integrative analysis of multi-omics data.
Lu X, Ma L, Yin X, Ji H, Qian Y, Zhong S, Yan A, Zhang Y
International immunopharmacology 2021 Dec;101(Pt B):108253
International immunopharmacology 2021 Dec;101(Pt B):108253
Tailoring Chemoimmunostimulant Bioscaffolds for Inhibiting Tumor Growth and Metastasis after Incomplete Microwave Ablation.
Shen Y, Chen L, Guan X, Han X, Bo X, Li S, Sun L, Chen Y, Yue W, Xu H
ACS nano 2021 Dec 28;15(12):20414-20429
ACS nano 2021 Dec 28;15(12):20414-20429
FABP4 deactivates NF-κB-IL1α pathway by ubiquitinating ATPB in tumor-associated macrophages and promotes neuroblastoma progression.
Miao L, Zhuo Z, Tang J, Huang X, Liu J, Wang HY, Xia H, He J
Clinical and translational medicine 2021 Apr;11(4):e395
Clinical and translational medicine 2021 Apr;11(4):e395
CD137 agonist induces gastric cancer cell apoptosis by enhancing the functions of CD8(+) T cells via NF-κB signaling.
Hu BS, Tang T, Jia JL, Xie BC, Wu TL, Sheng YY, Xue YZ, Tang HM
Cancer cell international 2020;20:513
Cancer cell international 2020;20:513
Role of GLUT-1 in the Upregulation of PD-L1 Expression After Radiotherapy and Association of PD-L1 with Favourable Overall Survival in Hypopharyngeal Cancer.
Shen LF, Zhou SH, Guo Y
OncoTargets and therapy 2020;13:11221-11235
OncoTargets and therapy 2020;13:11221-11235
Whole-Exome Sequencing Reveals New Potential Mutations Genes for Primary Mucosa-Associated Lymphoid Tissue Lymphoma Arising From the Kidney.
Wen S, Liu T, Zhang H, Zhou X, Jin H, Sun M, Yun Z, Luo H, Ni Z, Zhao R, Fan B
Frontiers in oncology 2020;10:609839
Frontiers in oncology 2020;10:609839
IDO1 Expression Increased After Neoadjuvant Therapy Predicts Poor Pathologic Response and Prognosis in Esophageal Squamous Cell Carcinoma.
Jiao R, Zheng X, Sun Y, Feng Z, Song S, Ge H
Frontiers in oncology 2020;10:1099
Frontiers in oncology 2020;10:1099
An IL6-Adenosine Positive Feedback Loop between CD73(+) γδTregs and CAFs Promotes Tumor Progression in Human Breast Cancer.
Hu G, Cheng P, Pan J, Wang S, Ding Q, Jiang Z, Cheng L, Shao X, Huang L, Huang J
Cancer immunology research 2020 Oct;8(10):1273-1286
Cancer immunology research 2020 Oct;8(10):1273-1286
The innate immune effector ISG12a promotes cancer immunity by suppressing the canonical Wnt/β-catenin signaling pathway.
Deng R, Zuo C, Li Y, Xue B, Xun Z, Guo Y, Wang X, Xu Y, Tian R, Chen S, Liu Q, Chen J, Wang J, Huang X, Li H, Guo M, Wang X, Yang M, Wu Z, Wang J, Ma J, Hu J, Li G, Tang S, Tu Z, Ji H, Zhu H
Cellular & molecular immunology 2020 Nov;17(11):1163-1179
Cellular & molecular immunology 2020 Nov;17(11):1163-1179
Metformin changes the immune microenvironment of colorectal cancer in patients with type 2 diabetes mellitus.
Saito A, Kitayama J, Horie H, Koinuma K, Ohzawa H, Yamaguchi H, Kawahira H, Mimura T, Lefor AK, Sata N
Cancer science 2020 Nov;111(11):4012-4020
Cancer science 2020 Nov;111(11):4012-4020
A Comparison of Splenic Pathologic Change and Immune Function in HBV-Related Portal Hypertension and Chinese Budd-Chiari Syndrome Patients with Hypersplenism.
Li S, Huang N, Dang X, Li L, Li Z, Zhang C, Jiang A, Kong G, Ji F, Yang J, Li Z
Viral immunology 2020 Mar;33(2):112-121
Viral immunology 2020 Mar;33(2):112-121
Single-Cell Transcriptome Analysis Reveals Intratumoral Heterogeneity in ccRCC, which Results in Different Clinical Outcomes.
Hu J, Chen Z, Bao L, Zhou L, Hou Y, Liu L, Xiong M, Zhang Y, Wang B, Tao Z, Chen K
Molecular therapy : the journal of the American Society of Gene Therapy 2020 Jul 8;28(7):1658-1672
Molecular therapy : the journal of the American Society of Gene Therapy 2020 Jul 8;28(7):1658-1672
NIR-Triggered Sequentially Responsive Nanocarriers Amplified Cascade Synergistic Effect of Chemo-Photodynamic Therapy with Inspired Antitumor Immunity.
Jin F, Qi J, Zhu M, Liu D, You Y, Shu G, Du Y, Wang J, Yu H, Sun M, Xu X, Shen Q, Ying X, Ji J, Du Y
ACS applied materials & interfaces 2020 Jul 22;12(29):32372-32387
ACS applied materials & interfaces 2020 Jul 22;12(29):32372-32387
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