Explore
Validate
Learn19834-1-AP
antibody from Proteintech Group
Targeting: TXNDC5
EndoPDI, ERp46, FLJ21353, FLJ90810, Hcc-2, MGC3178, PDIA15
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [16]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 19834-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#19834-1-AP, RRID:AB_10644285
- Product name
- TXNDC5 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated TXNDC5 antibody (Cat. #19834-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Modeling alcohol-associated liver disease in humans using adipose stromal or stem cell-derived organoids.
Thioredoxin domain containing 5 is involved in the hepatic storage of squalene into lipid droplets in a sex-specific way.
TBX15 facilitates malignant progression of glioma by transcriptional activation of TXDNC5.
Hepatitis E virus ORF3 protein hijacking thioredoxin domain-containing protein 5 (TXNDC5) for its stability to promote viral particle release.
Precisely Regulating M2 Subtype Macrophages for Renal Fibrosis Resolution.
Endoplasmic Reticulum Protein TXNDC5 Interacts with PRDX6 and HSPA9 to Regulate Glutathione Metabolism and Lipid Peroxidation in the Hepatic AML12 Cell Line.
Squalene Loaded Nanoparticles Effectively Protect Hepatic AML12 Cell Lines against Oxidative and Endoplasmic Reticulum Stress in a TXNDC5-Dependent Way.
Targeting mechanosensitive endothelial TXNDC5 to stabilize eNOS and reduce atherosclerosis in vivo.
A comprehensive set of ER protein disulfide isomerase family members supports the biogenesis of proinflammatory interleukin 12 family cytokines.
m(6)A Methyltransferase METTL3 Promotes the Progression of Primary Acral Melanoma via Mediating TXNDC5 Methylation.
Endoplasmic reticulum protein TXNDC5 promotes renal fibrosis by enforcing TGF-β signaling in kidney fibroblasts.
Inhibition of ER stress by targeting the IRE1α-TXNDC5 pathway alleviates crystalline silica-induced pulmonary fibrosis.
Counteracting Cisplatin-Induced Testicular Damages by Natural Polyphenol Constituent Honokiol.
Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFβ signaling through TGFBR1 stabilization.
High TXNDC5 expression predicts poor prognosis in renal cell carcinoma.
Mapping wild-type and R345W fibulin-3 intracellular interactomes.
Bi G, Zhang X, Li W, Lu X, He X, Li Y, Bai R, Zhang H
Cell reports methods 2024 May 20;4(5):100778
Cell reports methods 2024 May 20;4(5):100778
Thioredoxin domain containing 5 is involved in the hepatic storage of squalene into lipid droplets in a sex-specific way.
Sánchez-Marco J, Bidooki SH, Abuobeid R, Barranquero C, Herrero-Continente T, Arnal C, Martínez-Beamonte R, Lasheras R, Surra JC, Navarro MA, Rodríguez-Yoldi MJ, Arruebo M, Sebastian V, Osada J
The Journal of nutritional biochemistry 2024 Feb;124:109503
The Journal of nutritional biochemistry 2024 Feb;124:109503
TBX15 facilitates malignant progression of glioma by transcriptional activation of TXDNC5.
Ge Y, Jia B, Zhang P, Chen B, Liu L, Shi Y, Huang S, Liu X, Wang R, Xie Y, Li Z, Dong J
iScience 2024 Feb 16;27(2):108950
iScience 2024 Feb 16;27(2):108950
Hepatitis E virus ORF3 protein hijacking thioredoxin domain-containing protein 5 (TXNDC5) for its stability to promote viral particle release.
Sheng Y, Deng Y, Li X, Ji P, Sun X, Liu B, Zhu J, Zhao J, Nan Y, Zhou E-M, Hiscox JA, Stewart JP, Sun Y, Zhao Q
Journal of virology 2024 Apr 16;98(4):e0164923
Journal of virology 2024 Apr 16;98(4):e0164923
Precisely Regulating M2 Subtype Macrophages for Renal Fibrosis Resolution.
Luo L, Wang S, Hu Y, Wang L, Jiang X, Zhang J, Liu X, Guo X, Luo Z, Zhu C, Xie M, Li Y, You J, Yang F
ACS nano 2023 Nov 28;17(22):22508-22526
ACS nano 2023 Nov 28;17(22):22508-22526
Endoplasmic Reticulum Protein TXNDC5 Interacts with PRDX6 and HSPA9 to Regulate Glutathione Metabolism and Lipid Peroxidation in the Hepatic AML12 Cell Line.
Bidooki SH, Sánchez-Marco J, Martínez-Beamonte R, Herrero-Continente T, Navarro MA, Rodríguez-Yoldi MJ, Osada J
International journal of molecular sciences 2023 Dec 5;24(24)
International journal of molecular sciences 2023 Dec 5;24(24)
Squalene Loaded Nanoparticles Effectively Protect Hepatic AML12 Cell Lines against Oxidative and Endoplasmic Reticulum Stress in a TXNDC5-Dependent Way.
Bidooki SH, Alejo T, Sánchez-Marco J, Martínez-Beamonte R, Abuobeid R, Burillo JC, Lasheras R, Sebastian V, Rodríguez-Yoldi MJ, Arruebo M, Osada J
Antioxidants (Basel, Switzerland) 2022 Mar 18;11(3)
Antioxidants (Basel, Switzerland) 2022 Mar 18;11(3)
Targeting mechanosensitive endothelial TXNDC5 to stabilize eNOS and reduce atherosclerosis in vivo.
Yeh CF, Cheng SH, Lin YS, Shentu TP, Huang RT, Zhu J, Chen YT, Kumar S, Lin MS, Kao HL, Huang PH, Roselló-Sastre E, Garcia F, Jo H, Fang Y, Yang KC
Science advances 2022 Jan 21;8(3):eabl8096
Science advances 2022 Jan 21;8(3):eabl8096
A comprehensive set of ER protein disulfide isomerase family members supports the biogenesis of proinflammatory interleukin 12 family cytokines.
Mideksa YG, Aschenbrenner I, Fux A, Kaylani D, Weiß CAM, Nguyen TA, Bach NC, Lang K, Sieber SA, Feige MJ
The Journal of biological chemistry 2022 Dec;298(12):102677
The Journal of biological chemistry 2022 Dec;298(12):102677
m(6)A Methyltransferase METTL3 Promotes the Progression of Primary Acral Melanoma via Mediating TXNDC5 Methylation.
Yue Z, Cao M, Hong A, Zhang Q, Zhang G, Jin Z, Zhao L, Wang Q, Fang F, Wang Y, Sun J
Frontiers in oncology 2021;11:770325
Frontiers in oncology 2021;11:770325
Endoplasmic reticulum protein TXNDC5 promotes renal fibrosis by enforcing TGF-β signaling in kidney fibroblasts.
Chen YT, Jhao PY, Hung CT, Wu YF, Lin SJ, Chiang WC, Lin SL, Yang KC
The Journal of clinical investigation 2021 Mar 1;131(5)
The Journal of clinical investigation 2021 Mar 1;131(5)
Inhibition of ER stress by targeting the IRE1α-TXNDC5 pathway alleviates crystalline silica-induced pulmonary fibrosis.
Chen X, Li C, Liu J, He Y, Wei Y, Chen J
International immunopharmacology 2021 Jun;95:107519
International immunopharmacology 2021 Jun;95:107519
Counteracting Cisplatin-Induced Testicular Damages by Natural Polyphenol Constituent Honokiol.
Wang TE, Lai YH, Yang KC, Lin SJ, Chen CL, Tsai PS
Antioxidants (Basel, Switzerland) 2020 Aug 9;9(8)
Antioxidants (Basel, Switzerland) 2020 Aug 9;9(8)
Fibroblast-enriched endoplasmic reticulum protein TXNDC5 promotes pulmonary fibrosis by augmenting TGFβ signaling through TGFBR1 stabilization.
Lee TH, Yeh CF, Lee YT, Shih YC, Chen YT, Hung CT, You MY, Wu PC, Shentu TP, Huang RT, Lin YS, Wu YF, Lin SJ, Lu FL, Tsao PN, Lin TH, Lo SC, Tseng YS, Wu WL, Chen CN, Wu CC, Lin SL, Sperling AI, Guzy RD, Fang Y, Yang KC
Nature communications 2020 Aug 26;11(1):4254
Nature communications 2020 Aug 26;11(1):4254
High TXNDC5 expression predicts poor prognosis in renal cell carcinoma.
Mo R, Peng J, Xiao J, Ma J, Li W, Wang J, Ruan Y, Ma S, Hong Y, Wang C, Gao K, Fan J
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Jul;37(7):9797-806
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Jul;37(7):9797-806
Mapping wild-type and R345W fibulin-3 intracellular interactomes.
Hulleman JD, Genereux JC, Nguyen A
Experimental eye research 2016 Dec;153:165-169
Experimental eye research 2016 Dec;153:165-169
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HepG2 cells were subjected to SDS PAGE followed by western blot with 19834-1-AP(TXNDC5 antibody) at dilution of 1:300
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using TXNDC5 antibody 19834-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human colon cancer using 19834-1-AP(TXNDC5 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human colon cancer using 19834-1-AP(TXNDC5 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
