Antibody data
- Antibody Data
- Antigen structure
- References [15]
- Comments [0]
- Validations
- Immunohistochemistry [2]
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Validation data
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- Product number
- 10421-1-AP - Provider product page

- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10421-1-AP, RRID:AB_2244691
- Product name
- CEA antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CEA antibody (Cat. #10421-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IHC,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Rapid and sensitive detection of cancer-derived small extracellular vesicles using Janus particles.
Engineering a cancer organoid-based platform for the early preclinical evaluation of the antitumor efficacy and safety of hydrophilic 2D metallic MoS(2) nanosheets.
Targeted Inhibition of Colorectal Carcinoma Using a Designed CEA-Binding Protein to Deliver p53 Protein and TCF/LEF Transcription Factor Decoy DNA.
MiR-5095 inhibits proliferation, migration, and invasion of gastric cancer cells by targeting CEACAM5.
CD39 Contributes to the Ability of Cell Invasion in Heterogeneity of Colorectal Cancer.
Immunojanus Particles for low-volume and isolation-free unlabeled characterization of small Extracellular Vesicle in biofluids: Characterization of disease type by surface marker profiling.
CD146(+) CAFs mediate immunosuppression in gastric cancer via COL4A1: potential therapeutic targets.
Exosome-Mediated RUNX3 DNA Delivery for Lung Cancer Therapy.
Gastric cancer patient-derived organoids model for the therapeutic drug screening.
Preparation and application of patient-derived xenograft mice model of colorectal cancer.
Correlation of alpha-1 antitrypsin levels and exosome associated neutrophil elastase endothelial injury in subjects with SARS-CoV2 infection.
Molecular signature of interleukin-22 in colon carcinoma cells and organoid models.
FBW7 suppresses metastasis of colorectal cancer by inhibiting HIF1α/CEACAM5 functional axis.
Discovery of Aquaporin-1 and Aquaporin-4 Expression in an Intramedullary Spinal Cord Ependymal Cyst: Case Report.
Lentivirus-mediated RASSF1A expression suppresses aggressive phenotypes of gastric cancer cells in vitro and in vivo.
Kumar S, Sinclair JA, Shi T, Chuang HS, Senapati S, Chang HC
Nature biomedical engineering 2026 Mar 11;
Nature biomedical engineering 2026 Mar 11;
Engineering a cancer organoid-based platform for the early preclinical evaluation of the antitumor efficacy and safety of hydrophilic 2D metallic MoS(2) nanosheets.
Jin C, Gao X, Chen C, Chen Z, Zhang Y, Ji DK
Journal of colloid and interface science 2026 Feb;703(Pt 2):139206
Journal of colloid and interface science 2026 Feb;703(Pt 2):139206
Targeted Inhibition of Colorectal Carcinoma Using a Designed CEA-Binding Protein to Deliver p53 Protein and TCF/LEF Transcription Factor Decoy DNA.
Wang W, Sun X, Wu G
International journal of molecular sciences 2025 Oct 10;26(20)
International journal of molecular sciences 2025 Oct 10;26(20)
MiR-5095 inhibits proliferation, migration, and invasion of gastric cancer cells by targeting CEACAM5.
Lin W, Cai R, Fan W, Zhang X, He F, Miao Y, Qian H, Zhao W, Zhu Y
Scientific reports 2025 Nov 14;15(1):39950
Scientific reports 2025 Nov 14;15(1):39950
CD39 Contributes to the Ability of Cell Invasion in Heterogeneity of Colorectal Cancer.
Li X, Shen Y, Lang J, Wu J, Qian Z, Shen G, Shen Y
Journal of cellular and molecular medicine 2025 Mar;29(5):e70486
Journal of cellular and molecular medicine 2025 Mar;29(5):e70486
Immunojanus Particles for low-volume and isolation-free unlabeled characterization of small Extracellular Vesicle in biofluids: Characterization of disease type by surface marker profiling.
Kumar S, Sinclair JA, Shi T, Chuang HS, Senapati S, Chang HC
bioRxiv : the preprint server for biology 2025 Jul 16;
bioRxiv : the preprint server for biology 2025 Jul 16;
CD146(+) CAFs mediate immunosuppression in gastric cancer via COL4A1: potential therapeutic targets.
Chen J, Xu P, Wang Q, Dai J, Liang S, Yang S, Xie G, Li X, Wang Y, Hua H, Ping X, Shen J, Shen L
Journal for immunotherapy of cancer 2025 Dec 21;13(12)
Journal for immunotherapy of cancer 2025 Dec 21;13(12)
Exosome-Mediated RUNX3 DNA Delivery for Lung Cancer Therapy.
Jeon J, Byun H, Lee MC, Kim J, Park SG, Madrigal-Salazar AD, González ML, Lopez-Pacheco MC, Liu W, Nasr ML, Lee SH, Lee YS, Lee LP, Kim WJ, Kim D, Shin SR
ACS applied materials & interfaces 2025 Dec 10;17(49):66339-66357
ACS applied materials & interfaces 2025 Dec 10;17(49):66339-66357
Gastric cancer patient-derived organoids model for the therapeutic drug screening.
Xu J, Gong J, Li M, Kang Y, Ma J, Wang X, Liang X, Qi X, Yu B, Yang J
Biochimica et biophysica acta. General subjects 2024 Apr;1868(4):130566
Biochimica et biophysica acta. General subjects 2024 Apr;1868(4):130566
Preparation and application of patient-derived xenograft mice model of colorectal cancer.
Zhang Y, Yang Y, Zan L, Wang J, Yan L, Zhao L, Chen L, Xi Y, Bai W, Yang X
Iranian journal of basic medical sciences 2023 Feb;26(2):248-254
Iranian journal of basic medical sciences 2023 Feb;26(2):248-254
Correlation of alpha-1 antitrypsin levels and exosome associated neutrophil elastase endothelial injury in subjects with SARS-CoV2 infection.
Lascano J, Oshins R, Eagan C, Wadood Z, Qiang X, Flagg T, Scindia Y, Mehrad B, Brantly M, Khodayari N
PloS one 2022;17(9):e0274427
PloS one 2022;17(9):e0274427
Molecular signature of interleukin-22 in colon carcinoma cells and organoid models.
Rudloff I, Jardé T, Bachmann M, Elgass KD, Kerr G, Engel R, Richards E, Oliva K, Wilkins S, McMurrick PJ, Abud HE, Mühl H, Nold MF
Translational research : the journal of laboratory and clinical medicine 2020 Feb;216:1-22
Translational research : the journal of laboratory and clinical medicine 2020 Feb;216:1-22
FBW7 suppresses metastasis of colorectal cancer by inhibiting HIF1α/CEACAM5 functional axis.
Li Q, Li Y, Li J, Ma Y, Dai W, Mo S, Xu Y, Li X, Cai S
International journal of biological sciences 2018;14(7):726-735
International journal of biological sciences 2018;14(7):726-735
Discovery of Aquaporin-1 and Aquaporin-4 Expression in an Intramedullary Spinal Cord Ependymal Cyst: Case Report.
Shepard MJ, Padmanaban V, Edwards NA, Chittiboina P, Ray-Chaudhury A, Heiss JD
World neurosurgery 2017 Nov;107:1046.e1-1046.e7
World neurosurgery 2017 Nov;107:1046.e1-1046.e7
Lentivirus-mediated RASSF1A expression suppresses aggressive phenotypes of gastric cancer cells in vitro and in vivo.
Zhou PH, Zheng JB, Wei GB, Wang XL, Wang W, Chen NZ, Yu JH, Yao JF, Wang H, Lu SY, Sun XJ
Gene therapy 2015 Oct;22(10):793-801
Gene therapy 2015 Oct;22(10):793-801
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- Immunohistochemical of paraffin-embedded human colon cancer using 10421-1-AP(CEA antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- The CEA antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CEA. This antibody recognizes human antigen. The CEA antibody has been validated for the following applications: ELISA, IHC analysis.