FNab06734

antibody from FineTest Biotech

Targeting: PPP4R2

Western blot

ELISA

Immunohistochemistry

Antibody data

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Validation data

Product number: FNab06734 - Provider product page
Provider: FineTest Biotech
Product name: PPP4R2 antibody
Antibody type: Polyclonal
Antigen: Recombinant protein fragment
Description: Regulatory subunit of serine/threonine-protein phosphatase 4(PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140'(gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Antigen sequence: protein phosphatase 4, regulatory s ubunit 2
Epitope: IgG
Isotype: IgG
Vial size: 100¦Ìg
Concentration: Immunogen affinity purified
Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)
Handling: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20¡æ for 12 months(Avoid repeated freeze / thaw cycles.)

PPP4R2 protein structure - FNab06734 shown in red.