Antibody data
- Antibody Data
- Antigen structure
- References [80]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [2]
- Immunohistochemistry [5]
- Other assay [10]
Submit
Validation data
Reference
Comment
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- Product number
- MA5-13259 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- Desmin Monoclonal Antibody (D33)
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- MA5-13259 targets Desmin in IF and IHC (P) applications and shows reactivity with Bovine, Canine, Chicken, Feline, Hamster, Human, Non-human primate, and Rat samples. The MA5-13259 immunogen is desmin from human muscle.
- Reactivity
- Human, Rat, Bovine, Canine, Chicken/Avian, Feline, Hamster
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- D33
- Vial size
- 500 µL
- Concentration
- 0.2 mg/mL
- Storage
- 4° C
Submitted references Development and characterization of a CRISPR/Cas9-mediated RAG1 knockout chicken model lacking mature B and T cells.
Development of ribs and intercostal muscles in the chicken embryo.
Rapid 3D-STORM imaging of diverse molecular targets in tissue.
Retinoic acid exerts sexually dimorphic effects on muscle energy metabolism and function.
Early Changes in Rat Heart After High-Dose Irradiation: Implications for Antiarrhythmic Effects of Cardiac Radioablation.
CDKN2a/p16 Antagonizes Hepatic Stellate Cell Activation and Liver Fibrosis by Modulating ROS Levels.
Omega-3 Polyunsaturated Fatty Acids Mitigate Palmitate-Induced Impairments in Skeletal Muscle Cell Viability and Differentiation.
Urinary cMet as a prognostic marker in immunoglobulin A nephropathy.
Identification of the intermediate filament protein synemin/SYNM as a target of myocardin family coactivators.
Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells.
Fibroblastic reticular cell tumor of the breast: A case report and review of the literature.
PDGFR-β (+) perivascular cells from infantile hemangioma display the features of mesenchymal stem cells and show stronger adipogenic potential in vitro and in vivo.
Contribution of DOG1 expression to the diagnosis of gastrointestinal stromal tumors.
Gingival rhabdomyosarcoma accompanied by an immature myogenic population immunoreactive for α-smooth muscle actin in a dog.
Efficient generation of human iPSCs by a synthetic self-replicative RNA.
Dural angioleiomyoma of the middle cranial fossa: a case report and review of the literature.
Low-grade myofibroblastic sarcoma of the maxillary region in a dog.
Sclerosing angiomatoid nodular transformation of the spleen: report of five cases and review of literature.
Lymphoid tissue damage in HIV-1 infection depletes naïve T cells and limits T cell reconstitution after antiretroviral therapy.
Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion.
Chondrogenic differentiation of induced pluripotent stem cells from osteoarthritic chondrocytes in alginate matrix.
Pancreatic carcinosarcoma in a cat.
Cotyledonoid leiomyoma of uterus: a case report.
A comprehensive characterization study of human bone marrow mscs with an emphasis on molecular and ultrastructural properties.
The expressions of HSP70 and αB-crystallin in myocarditis associated with foot-and-mouth disease virus in lambs.
The expressions of HSP70 and αB-crystallin in myocarditis associated with foot-and-mouth disease virus in lambs.
Establishment of clonal myogenic cell lines from severely affected dystrophic muscles - CDK4 maintains the myogenic population.
Mesenchymal stem cells improve the healing of ischemic colonic anastomoses (experimental study).
Microscopic uterine lymphangioleiomyomatosis perivascular epithelioid cell neoplasm: a case report with the earliest manifestation of this enigmatic neoplasm.
Undifferentiated high-grade pleomorphic sarcoma in a California sea lion (Zalophus californianus).
Clinicopathologic features of 2 new cases of uterine tumors resembling ovarian sex cord tumors.
Adipose tissue progenitor cells directly interact with endothelial cells to induce vascular network formation.
Pancreatic islet derived stem cells can express co-stimulatory molecules of antigen-presenting cells.
Ectomesenchymal chondromyxoid tumour of the tongue. A review of histological and immunohistochemical features.
Establishment and characterization of the rhabdomyosarcoma cell line designated NUTOS derived from the human tongue sarcoma: Special reference to the susceptibility of anti-cancer drugs.
Wnt activity defines colon cancer stem cells and is regulated by the microenvironment.
Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome.
Isolation and in vitro characterisation of dental pulp stem cells from natal teeth.
Polymer transfected primary myoblasts mediated efficient gene expression and angiogenic proliferation.
Adenomyofibroma of the fimbria in a cynomolgus monkey (Macaca fascicularis).
Characterization of mesenchymal stem cells from rat bone marrow: ultrastructural properties, differentiation potential and immunophenotypic markers.
Cyclooxygenase-2 expression and connection with tumor recurrence and histopathologic parameters in gastrointestinal stromal tumors.
Dendritic cell sarcomas/tumours of the breast: report of two cases.
Giant cell tumor-like lesion of the urinary bladder: a report of two cases and literature review; giant cell tumor or undifferentiated carcinoma?
Dedifferentiated Liposarcoma of the Retroperitoneum with Extensive Leiomyosarcomatous Differentiation and beta-Human Chorionic Gonadotropin Production.
Multiple primary sporadic gastrointestinal stromal tumors in the adult: an underestimated entity.
Extensive contribution of embryonic stem cells to the development of an evolutionarily divergent host.
Epithelioid leiomyosarcoma with rhabdoid features.
Gene expression programs of human smooth muscle cells: tissue-specific differentiation and prognostic significance in breast cancers.
Vulvar leiomyosarcoma in a cat.
Myointimoma of the glans penis.
Elastofibroma: a clinicopathologic and immunohistochemical study of seven cases and literature review.
Kit expression in spindle cell rhabdomyosarcoma can possibly create a different approach for its tumorigenesis and therapy.
Long-term effect of experimental hypercholesterolemia on cavernosal tissues.
Soft tissue sacrococcygeal chordoma with intracytoplasmic filamentous inclusions.
Mesenchymal hamartoma of the liver in adulthood: immunohistochemical profiles, clinical and histopathological features in two patients.
Atypical endometrial stromal cells related with a polypoid leiomyoma with bizarre nuclei: a case report.
Atypical endometrial stromal cells related with a polypoid leiomyoma with bizarre nuclei: a case report.
Reactive nodular fibrous pseudotumor involving the pelvic and abdominal cavity: a case report and review of literature.
Interdigitating dendritic cell tumor with breast and cervical lymph-node involvement: a case report and review of the literature.
Analysis of prognostic and immunohistochemical factors in gastrointestinal stromal tumors with malignant potential.
Inflammatory pseudotumor of the kidney.
Inflammatory pseudotumor of the kidney.
Intra-abdominal fibromatosis of the jejunum and mesentery.
Collagenous fibroma (desmoplastic fibroblastoma).
Collagenous fibroma (desmoplastic fibroblastoma).
Endothelial cell diversity revealed by global expression profiling.
Smooth muscle cell differentiation in mammary stromo-epithelial lesions with evidence of a dual origin: stromal myofibroblasts and myoepithelial cells.
Smooth muscle cell differentiation in mammary stromo-epithelial lesions with evidence of a dual origin: stromal myofibroblasts and myoepithelial cells.
Malignant neoplasms infiltrating pseudoangiomatous' stromal hyperplasia of the breast: an unrecognized pathway of tumour spread.
Malignant neoplasms infiltrating pseudoangiomatous' stromal hyperplasia of the breast: an unrecognized pathway of tumour spread.
Tissue engineering of functional trileaflet heart valves from human marrow stromal cells.
Human umbilical cord cells: a new cell source for cardiovascular tissue engineering.
Human umbilical cord cells: a new cell source for cardiovascular tissue engineering.
A new source for cardiovascular tissue engineering: human bone marrow stromal cells.
A new source for cardiovascular tissue engineering: human bone marrow stromal cells.
Living, autologous pulmonary artery conduits tissue engineered from human umbilical cord cells.
Living, autologous pulmonary artery conduits tissue engineered from human umbilical cord cells.
Two intraligamentary lipomatous tumors with immunohistochemical features.
Two intraligamentary lipomatous tumors with immunohistochemical features.
Lee KY, Choi HJ, Park KJ, Woo SJ, Kim YM, Han JY
Frontiers in immunology 2022;13:892476
Frontiers in immunology 2022;13:892476
Development of ribs and intercostal muscles in the chicken embryo.
Khabyuk J, Pröls F, Draga M, Scaal M
Journal of anatomy 2022 Sep;241(3):831-845
Journal of anatomy 2022 Sep;241(3):831-845
Rapid 3D-STORM imaging of diverse molecular targets in tissue.
Albrecht NE, Jiang D, Akhanov V, Hobson R, Speer CM, Robichaux MA, Samuel MA
Cell reports methods 2022 Jul 18;2(7):100253
Cell reports methods 2022 Jul 18;2(7):100253
Retinoic acid exerts sexually dimorphic effects on muscle energy metabolism and function.
Zhao Y, Vuckovic M, Yoo HS, Fox N, Rodriguez A, McKessy K, Napoli JL
The Journal of biological chemistry 2021 Sep;297(3):101101
The Journal of biological chemistry 2021 Sep;297(3):101101
Early Changes in Rat Heart After High-Dose Irradiation: Implications for Antiarrhythmic Effects of Cardiac Radioablation.
Cha MJ, Seo JW, Kim HJ, Kim MK, Yoon HS, Jo SW, Oh S, Chang JH
Journal of the American Heart Association 2021 Mar 16;10(6):e019072
Journal of the American Heart Association 2021 Mar 16;10(6):e019072
CDKN2a/p16 Antagonizes Hepatic Stellate Cell Activation and Liver Fibrosis by Modulating ROS Levels.
Lv F, Li N, Kong M, Wu J, Fan Z, Miao D, Xu Y, Ye Q, Wang Y
Frontiers in cell and developmental biology 2020;8:176
Frontiers in cell and developmental biology 2020;8:176
Omega-3 Polyunsaturated Fatty Acids Mitigate Palmitate-Induced Impairments in Skeletal Muscle Cell Viability and Differentiation.
Tachtsis B, Whitfield J, Hawley JA, Hoffman NJ
Frontiers in physiology 2020;11:563
Frontiers in physiology 2020;11:563
Urinary cMet as a prognostic marker in immunoglobulin A nephropathy.
An JN, Li L, Lee J, Yu SS, Kim JH, Lee J, Kim YC, Kim DK, Oh YK, Lim CS, Kim YS, Kim S, Yang SH, Lee JP
Journal of cellular and molecular medicine 2020 Oct;24(19):11158-11169
Journal of cellular and molecular medicine 2020 Oct;24(19):11158-11169
Identification of the intermediate filament protein synemin/SYNM as a target of myocardin family coactivators.
Swärd K, Krawczyk KK, Morén B, Zhu B, Matic L, Holmberg J, Hedin U, Uvelius B, Stenkula K, Rippe C
American journal of physiology. Cell physiology 2019 Dec 1;317(6):C1128-C1142
American journal of physiology. Cell physiology 2019 Dec 1;317(6):C1128-C1142
Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells.
Takahashi A, Loo TM, Okada R, Kamachi F, Watanabe Y, Wakita M, Watanabe S, Kawamoto S, Miyata K, Barber GN, Ohtani N, Hara E
Nature communications 2018 Mar 28;9(1):1249
Nature communications 2018 Mar 28;9(1):1249
Fibroblastic reticular cell tumor of the breast: A case report and review of the literature.
Li H, Shen P, Liang Y, Zhang F
Experimental and therapeutic medicine 2016 Feb;11(2):561-564
Experimental and therapeutic medicine 2016 Feb;11(2):561-564
PDGFR-β (+) perivascular cells from infantile hemangioma display the features of mesenchymal stem cells and show stronger adipogenic potential in vitro and in vivo.
Yuan SM, Guo Y, Zhou XJ, Shen WM, Chen HN
International journal of clinical and experimental pathology 2014;7(6):2861-70
International journal of clinical and experimental pathology 2014;7(6):2861-70
Contribution of DOG1 expression to the diagnosis of gastrointestinal stromal tumors.
Kara T, Serinsoz E, Arpaci RB, Gubur O, Orekici G, Ata A, Colak T, Arican A
Pathology, research and practice 2013 Jul;209(7):413-7
Pathology, research and practice 2013 Jul;209(7):413-7
Gingival rhabdomyosarcoma accompanied by an immature myogenic population immunoreactive for α-smooth muscle actin in a dog.
Kimura M, Suzuki K, Fujii Y, Yamamoto R, Shibutani M, Mitsumori K
Journal of comparative pathology 2013 Jul;149(1):48-52
Journal of comparative pathology 2013 Jul;149(1):48-52
Efficient generation of human iPSCs by a synthetic self-replicative RNA.
Yoshioka N, Gros E, Li HR, Kumar S, Deacon DC, Maron C, Muotri AR, Chi NC, Fu XD, Yu BD, Dowdy SF
Cell stem cell 2013 Aug 1;13(2):246-54
Cell stem cell 2013 Aug 1;13(2):246-54
Dural angioleiomyoma of the middle cranial fossa: a case report and review of the literature.
Zhou Z, Yu M, Yang S, Zhou J, Sun R, Yang G
Brain tumor pathology 2013 Apr;30(2):117-21
Brain tumor pathology 2013 Apr;30(2):117-21
Low-grade myofibroblastic sarcoma of the maxillary region in a dog.
Tsuchiya T, Suzuki K, Hojo Y, Shiraki A, Imaoka M, Shibutani M, Mitsumori K
Journal of comparative pathology 2012 Jul;147(1):42-5
Journal of comparative pathology 2012 Jul;147(1):42-5
Sclerosing angiomatoid nodular transformation of the spleen: report of five cases and review of literature.
Wang HL, Li KW, Wang J
Chinese medical journal 2012 Jul;125(13):2386-9
Chinese medical journal 2012 Jul;125(13):2386-9
Lymphoid tissue damage in HIV-1 infection depletes naïve T cells and limits T cell reconstitution after antiretroviral therapy.
Zeng M, Southern PJ, Reilly CS, Beilman GJ, Chipman JG, Schacker TW, Haase AT
PLoS pathogens 2012 Jan;8(1):e1002437
PLoS pathogens 2012 Jan;8(1):e1002437
Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion.
Hasegawa K, Yasuda SY, Teo JL, Nguyen C, McMillan M, Hsieh CL, Suemori H, Nakatsuji N, Yamamoto M, Miyabayashi T, Lutzko C, Pera MF, Kahn M
Stem cells translational medicine 2012 Jan;1(1):18-28
Stem cells translational medicine 2012 Jan;1(1):18-28
Chondrogenic differentiation of induced pluripotent stem cells from osteoarthritic chondrocytes in alginate matrix.
Wei Y, Zeng W, Wan R, Wang J, Zhou Q, Qiu S, Singh SR
European cells & materials 2012 Jan 12;23:1-12
European cells & materials 2012 Jan 12;23:1-12
Pancreatic carcinosarcoma in a cat.
Yamamoto R, Suzuki K, Uchida K, Onda N, Shibutani M, Mitsumori K
Journal of comparative pathology 2012 Aug-Oct;147(2-3):223-6
Journal of comparative pathology 2012 Aug-Oct;147(2-3):223-6
Cotyledonoid leiomyoma of uterus: a case report.
Ersöz S, Turgutalp H, Mungan S, Güvendı G, Güven S
Turk patoloji dergisi 2011;27(3):257-60
Turk patoloji dergisi 2011;27(3):257-60
A comprehensive characterization study of human bone marrow mscs with an emphasis on molecular and ultrastructural properties.
Karaöz E, Okçu A, Gacar G, Sağlam O, Yürüker S, Kenar H
Journal of cellular physiology 2011 May;226(5):1367-82
Journal of cellular physiology 2011 May;226(5):1367-82
The expressions of HSP70 and αB-crystallin in myocarditis associated with foot-and-mouth disease virus in lambs.
Gulbahar MY, Kabak YB, Karayigit MO, Yarim M, Guvenc T, Parlak U
Journal of veterinary science 2011 Mar;12(1):65-73
Journal of veterinary science 2011 Mar;12(1):65-73
The expressions of HSP70 and αB-crystallin in myocarditis associated with foot-and-mouth disease virus in lambs.
Gulbahar MY, Kabak YB, Karayigit MO, Yarim M, Guvenc T, Parlak U
Journal of veterinary science 2011 Mar;12(1):65-73
Journal of veterinary science 2011 Mar;12(1):65-73
Establishment of clonal myogenic cell lines from severely affected dystrophic muscles - CDK4 maintains the myogenic population.
Stadler G, Chen JC, Wagner K, Robin JD, Shay JW, Emerson CP Jr, Wright WE
Skeletal muscle 2011 Mar 8;1(1):12
Skeletal muscle 2011 Mar 8;1(1):12
Mesenchymal stem cells improve the healing of ischemic colonic anastomoses (experimental study).
Adas G, Arikan S, Karatepe O, Kemik O, Ayhan S, Karaoz E, Kamali G, Eryasar B, Ustek D
Langenbeck's archives of surgery 2011 Jan;396(1):115-26
Langenbeck's archives of surgery 2011 Jan;396(1):115-26
Microscopic uterine lymphangioleiomyomatosis perivascular epithelioid cell neoplasm: a case report with the earliest manifestation of this enigmatic neoplasm.
Clay MR, Gibson P, Lowell J, Cooper K
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2011 Jan;30(1):71-5
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2011 Jan;30(1):71-5
Undifferentiated high-grade pleomorphic sarcoma in a California sea lion (Zalophus californianus).
Martínez-Fernández B, García-Iglesias MJ, Borragán-Santos S, Espinosa-Alvarez J, Pérez-Martínez C
Journal of comparative pathology 2011 Feb-Apr;144(2-3):200-3
Journal of comparative pathology 2011 Feb-Apr;144(2-3):200-3
Clinicopathologic features of 2 new cases of uterine tumors resembling ovarian sex cord tumors.
Giordano G, Lombardi M, Brigati F, Mancini C, Silini EM
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2010 Sep;29(5):459-67
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2010 Sep;29(5):459-67
Adipose tissue progenitor cells directly interact with endothelial cells to induce vascular network formation.
Merfeld-Clauss S, Gollahalli N, March KL, Traktuev DO
Tissue engineering. Part A 2010 Sep;16(9):2953-66
Tissue engineering. Part A 2010 Sep;16(9):2953-66
Pancreatic islet derived stem cells can express co-stimulatory molecules of antigen-presenting cells.
Karaoz E, Okçu A, Saglam O, Genc ZS, Ayhan S, Kasap M
Transplantation proceedings 2010 Nov;42(9):3663-70
Transplantation proceedings 2010 Nov;42(9):3663-70
Ectomesenchymal chondromyxoid tumour of the tongue. A review of histological and immunohistochemical features.
Angiero F
Anticancer research 2010 Nov;30(11):4685-9
Anticancer research 2010 Nov;30(11):4685-9
Establishment and characterization of the rhabdomyosarcoma cell line designated NUTOS derived from the human tongue sarcoma: Special reference to the susceptibility of anti-cancer drugs.
Suzuki M, Tominaga N, Ide Y, Ohyama A, Nakahara T, Ishikawa H, Tanaka A, Mataga I
Human cell 2010 May;23(2):65-73
Human cell 2010 May;23(2):65-73
Wnt activity defines colon cancer stem cells and is regulated by the microenvironment.
Vermeulen L, De Sousa E Melo F, van der Heijden M, Cameron K, de Jong JH, Borovski T, Tuynman JB, Todaro M, Merz C, Rodermond H, Sprick MR, Kemper K, Richel DJ, Stassi G, Medema JP
Nature cell biology 2010 May;12(5):468-76
Nature cell biology 2010 May;12(5):468-76
Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome.
Carvajal-Vergara X, Sevilla A, D'Souza SL, Ang YS, Schaniel C, Lee DF, Yang L, Kaplan AD, Adler ED, Rozov R, Ge Y, Cohen N, Edelmann LJ, Chang B, Waghray A, Su J, Pardo S, Lichtenbelt KD, Tartaglia M, Gelb BD, Lemischka IR
Nature 2010 Jun 10;465(7299):808-12
Nature 2010 Jun 10;465(7299):808-12
Isolation and in vitro characterisation of dental pulp stem cells from natal teeth.
Karaöz E, Doğan BN, Aksoy A, Gacar G, Akyüz S, Ayhan S, Genç ZS, Yürüker S, Duruksu G, Demircan PC, Sariboyaci AE
Histochemistry and cell biology 2010 Jan;133(1):95-112
Histochemistry and cell biology 2010 Jan;133(1):95-112
Polymer transfected primary myoblasts mediated efficient gene expression and angiogenic proliferation.
Ou M, Kim TI, Yockman JW, Borden BA, Bull DA, Kim SW
Journal of controlled release : official journal of the Controlled Release Society 2010 Feb 25;142(1):61-9
Journal of controlled release : official journal of the Controlled Release Society 2010 Feb 25;142(1):61-9
Adenomyofibroma of the fimbria in a cynomolgus monkey (Macaca fascicularis).
Starost MF
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc 2009 Nov;21(6):892-4
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc 2009 Nov;21(6):892-4
Characterization of mesenchymal stem cells from rat bone marrow: ultrastructural properties, differentiation potential and immunophenotypic markers.
Karaoz E, Aksoy A, Ayhan S, Sariboyaci AE, Kaymaz F, Kasap M
Histochemistry and cell biology 2009 Nov;132(5):533-46
Histochemistry and cell biology 2009 Nov;132(5):533-46
Cyclooxygenase-2 expression and connection with tumor recurrence and histopathologic parameters in gastrointestinal stromal tumors.
Türköz HK, Alkan I, Sişman S, Ozcan D
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2009 Nov;117(11):825-30
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2009 Nov;117(11):825-30
Dendritic cell sarcomas/tumours of the breast: report of two cases.
Kapucuoglu N, Percinel S, Ventura T, Lang R, Al-Daraji W, Eusebi V
Virchows Archiv : an international journal of pathology 2009 Mar;454(3):333-9
Virchows Archiv : an international journal of pathology 2009 Mar;454(3):333-9
Giant cell tumor-like lesion of the urinary bladder: a report of two cases and literature review; giant cell tumor or undifferentiated carcinoma?
Behzatoğlu K, Durak H, Canberk S, Aydin O, Huq GE, Oznur M, Ozyalvaçli G, Yildiz P
Diagnostic pathology 2009 Dec 31;4:48
Diagnostic pathology 2009 Dec 31;4:48
Dedifferentiated Liposarcoma of the Retroperitoneum with Extensive Leiomyosarcomatous Differentiation and beta-Human Chorionic Gonadotropin Production.
Russell MJ, Flynt FL, Harroff AL, Fadare O
Sarcoma 2008;2008:658090
Sarcoma 2008;2008:658090
Multiple primary sporadic gastrointestinal stromal tumors in the adult: an underestimated entity.
Gasparotto D, Rossi S, Bearzi I, Doglioni C, Marzotto A, Hornick JL, Grizzo A, Sartor C, Mandolesi A, Sciot R, Debiec-Rychter M, Dei Tos AP, Maestro R
Clinical cancer research : an official journal of the American Association for Cancer Research 2008 Sep 15;14(18):5715-21
Clinical cancer research : an official journal of the American Association for Cancer Research 2008 Sep 15;14(18):5715-21
Extensive contribution of embryonic stem cells to the development of an evolutionarily divergent host.
Xiang AP, Mao FF, Li WQ, Park D, Ma BF, Wang T, Vallender TW, Vallender EJ, Zhang L, Lee J, Waters JA, Zhang XM, Yu XB, Li SN, Lahn BT
Human molecular genetics 2008 Jan 1;17(1):27-37
Human molecular genetics 2008 Jan 1;17(1):27-37
Epithelioid leiomyosarcoma with rhabdoid features.
Yorulmaz G, Erdogan G, Pestereli HE, Savas B, Karaveli FS
Wiener klinische Wochenschrift 2007;119(17-18):557-60
Wiener klinische Wochenschrift 2007;119(17-18):557-60
Gene expression programs of human smooth muscle cells: tissue-specific differentiation and prognostic significance in breast cancers.
Chi JT, Rodriguez EH, Wang Z, Nuyten DS, Mukherjee S, van de Rijn M, van de Vijver MJ, Hastie T, Brown PO
PLoS genetics 2007 Sep;3(9):1770-84
PLoS genetics 2007 Sep;3(9):1770-84
Vulvar leiomyosarcoma in a cat.
Firat I, Haktanir-Yatkin D, Sontas BH, Ekici H
Journal of feline medicine and surgery 2007 Oct;9(5):435-8
Journal of feline medicine and surgery 2007 Oct;9(5):435-8
Myointimoma of the glans penis.
Vardar E, Gunlusoy B, Arslan M, Kececi S
Pathology international 2007 Mar;57(3):158-61
Pathology international 2007 Mar;57(3):158-61
Elastofibroma: a clinicopathologic and immunohistochemical study of seven cases and literature review.
Gun BD, Bahadir B, Behzatoglu K, Gun MO, Ozdamar SO
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2007 Feb;115(2):115-9
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2007 Feb;115(2):115-9
Kit expression in spindle cell rhabdomyosarcoma can possibly create a different approach for its tumorigenesis and therapy.
Diniz G, Aktas S, Ortac R, Tunakan M, Unlu I, Vergin C
Pathology, research and practice 2006;202(9):671-7
Pathology, research and practice 2006;202(9):671-7
Long-term effect of experimental hypercholesterolemia on cavernosal tissues.
Karaboga R, Kilic O, Yaman O, Percinel S, Anafarta K
Urology 2006 Feb;67(2):431-4
Urology 2006 Feb;67(2):431-4
Soft tissue sacrococcygeal chordoma with intracytoplasmic filamentous inclusions.
Guarino M, Ballabio G, Rubino B, Nebuloni M, Tosoni A
Pathology, research and practice 2005;201(10):699-704
Pathology, research and practice 2005;201(10):699-704
Mesenchymal hamartoma of the liver in adulthood: immunohistochemical profiles, clinical and histopathological features in two patients.
Yesim G, Gupse T, Zafer U, Ahmet A
Journal of hepato-biliary-pancreatic surgery 2005;12(6):502-7
Journal of hepato-biliary-pancreatic surgery 2005;12(6):502-7
Atypical endometrial stromal cells related with a polypoid leiomyoma with bizarre nuclei: a case report.
Usubütün A, Karaman N, Ayhan A, Küçükali T
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2005 Oct;24(4):352-4
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2005 Oct;24(4):352-4
Atypical endometrial stromal cells related with a polypoid leiomyoma with bizarre nuclei: a case report.
Usubütün A, Karaman N, Ayhan A, Küçükali T
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2005 Oct;24(4):352-4
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2005 Oct;24(4):352-4
Reactive nodular fibrous pseudotumor involving the pelvic and abdominal cavity: a case report and review of literature.
Saglam EA, Usubütün A, Kart C, Ayhan A, Küçükali T
Virchows Archiv : an international journal of pathology 2005 Nov;447(5):879-82
Virchows Archiv : an international journal of pathology 2005 Nov;447(5):879-82
Interdigitating dendritic cell tumor with breast and cervical lymph-node involvement: a case report and review of the literature.
Uluoğlu O, Akyürek N, Uner A, Coşkun U, Ozdemir A, Gökçora N
Virchows Archiv : an international journal of pathology 2005 May;446(5):546-54
Virchows Archiv : an international journal of pathology 2005 May;446(5):546-54
Analysis of prognostic and immunohistochemical factors in gastrointestinal stromal tumors with malignant potential.
Ozgüç H, Yilmazlar T, Yerci O, Soylu R, Tümay V, Filiz G, Zorluoglu A
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2005 Mar;9(3):418-29
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 2005 Mar;9(3):418-29
Inflammatory pseudotumor of the kidney.
Bildirici K, Dönmez T, Gürlek E
International urology and nephrology 2004;36(2):141-3
International urology and nephrology 2004;36(2):141-3
Inflammatory pseudotumor of the kidney.
Bildirici K, Dönmez T, Gürlek E
International urology and nephrology 2004;36(2):141-3
International urology and nephrology 2004;36(2):141-3
Intra-abdominal fibromatosis of the jejunum and mesentery.
Pai SA, Zaveri SS
Journal of clinical pathology 2004 Oct;57(10):1119
Journal of clinical pathology 2004 Oct;57(10):1119
Collagenous fibroma (desmoplastic fibroblastoma).
Dagli M, Eryilmaz A, Acar A, Kulacoglu S, Akmansu H
Yonsei medical journal 2004 Oct 31;45(5):941-3
Yonsei medical journal 2004 Oct 31;45(5):941-3
Collagenous fibroma (desmoplastic fibroblastoma).
Dagli M, Eryilmaz A, Acar A, Kulacoglu S, Akmansu H
Yonsei medical journal 2004 Oct 31;45(5):941-3
Yonsei medical journal 2004 Oct 31;45(5):941-3
Endothelial cell diversity revealed by global expression profiling.
Chi JT, Chang HY, Haraldsen G, Jahnsen FL, Troyanskaya OG, Chang DS, Wang Z, Rockson SG, van de Rijn M, Botstein D, Brown PO
Proceedings of the National Academy of Sciences of the United States of America 2003 Sep 16;100(19):10623-8
Proceedings of the National Academy of Sciences of the United States of America 2003 Sep 16;100(19):10623-8
Smooth muscle cell differentiation in mammary stromo-epithelial lesions with evidence of a dual origin: stromal myofibroblasts and myoepithelial cells.
Di Tommaso L, Pasquinelli G, Damiani S
Histopathology 2003 May;42(5):448-56
Histopathology 2003 May;42(5):448-56
Smooth muscle cell differentiation in mammary stromo-epithelial lesions with evidence of a dual origin: stromal myofibroblasts and myoepithelial cells.
Di Tommaso L, Pasquinelli G, Damiani S
Histopathology 2003 May;42(5):448-56
Histopathology 2003 May;42(5):448-56
Malignant neoplasms infiltrating pseudoangiomatous' stromal hyperplasia of the breast: an unrecognized pathway of tumour spread.
Damiani S, Eusebi V, Peterse JL
Histopathology 2002 Sep;41(3):208-15
Histopathology 2002 Sep;41(3):208-15
Malignant neoplasms infiltrating pseudoangiomatous' stromal hyperplasia of the breast: an unrecognized pathway of tumour spread.
Damiani S, Eusebi V, Peterse JL
Histopathology 2002 Sep;41(3):208-15
Histopathology 2002 Sep;41(3):208-15
Tissue engineering of functional trileaflet heart valves from human marrow stromal cells.
Hoerstrup SP, Kadner A, Melnitchouk S, Trojan A, Eid K, Tracy J, Sodian R, Visjager JF, Kolb SA, Grunenfelder J, Zund G, Turina MI
Circulation 2002 Sep 24;106(12 Suppl 1):I143-50
Circulation 2002 Sep 24;106(12 Suppl 1):I143-50
Human umbilical cord cells: a new cell source for cardiovascular tissue engineering.
Kadner A, Hoerstrup SP, Tracy J, Breymann C, Maurus CF, Melnitchouk S, Kadner G, Zund G, Turina M
The Annals of thoracic surgery 2002 Oct;74(4):S1422-8
The Annals of thoracic surgery 2002 Oct;74(4):S1422-8
Human umbilical cord cells: a new cell source for cardiovascular tissue engineering.
Kadner A, Hoerstrup SP, Tracy J, Breymann C, Maurus CF, Melnitchouk S, Kadner G, Zund G, Turina M
The Annals of thoracic surgery 2002 Oct;74(4):S1422-8
The Annals of thoracic surgery 2002 Oct;74(4):S1422-8
A new source for cardiovascular tissue engineering: human bone marrow stromal cells.
Kadner A, Hoerstrup SP, Zund G, Eid K, Maurus C, Melnitchouk S, Grunenfelder J, Turina MI
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 2002 Jun;21(6):1055-60
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 2002 Jun;21(6):1055-60
A new source for cardiovascular tissue engineering: human bone marrow stromal cells.
Kadner A, Hoerstrup SP, Zund G, Eid K, Maurus C, Melnitchouk S, Grunenfelder J, Turina MI
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 2002 Jun;21(6):1055-60
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 2002 Jun;21(6):1055-60
Living, autologous pulmonary artery conduits tissue engineered from human umbilical cord cells.
Hoerstrup SP, Kadner A, Breymann C, Maurus CF, Guenter CI, Sodian R, Visjager JF, Zund G, Turina MI
The Annals of thoracic surgery 2002 Jul;74(1):46-52; discussion 52
The Annals of thoracic surgery 2002 Jul;74(1):46-52; discussion 52
Living, autologous pulmonary artery conduits tissue engineered from human umbilical cord cells.
Hoerstrup SP, Kadner A, Breymann C, Maurus CF, Guenter CI, Sodian R, Visjager JF, Zund G, Turina MI
The Annals of thoracic surgery 2002 Jul;74(1):46-52; discussion 52
The Annals of thoracic surgery 2002 Jul;74(1):46-52; discussion 52
Two intraligamentary lipomatous tumors with immunohistochemical features.
Cinel L, Düşmez D, Nabaei SH, Taner D, Pata O
Acta obstetricia et gynecologica Scandinavica 2002 Aug;81(8):786-7
Acta obstetricia et gynecologica Scandinavica 2002 Aug;81(8):786-7
Two intraligamentary lipomatous tumors with immunohistochemical features.
Cinel L, Düşmez D, Nabaei SH, Taner D, Pata O
Acta obstetricia et gynecologica Scandinavica 2002 Aug;81(8):786-7
Acta obstetricia et gynecologica Scandinavica 2002 Aug;81(8):786-7
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- Western blot was performed using Anti-Desmin Monoclonal Antibody (D33) (Product # MA5-13259) and a 53 kDa band corresponding to desmin was observed in RD as compared to no expression in MCF7. Whole cell extracts (30 µg lysate) of RD (Lane 1) and MCF7 (Lane 2) were electrophoresed using NuPAGE™ 10% Bis-Tris Protein Gel (Product # NP0302BOX), 12 well. Resolved proteins were then transferred onto a nitrocellulose membrane (Product # IB23001) by iBlot® 2 Dry Blotting System (Product # IB21001). The blot was probed with the primary antibody (1:1000 dilution) and detected by chemiluminescence with Goat anti-Mouse IgG (H+L) Superclonal™ Recombinant Secondary Antibody, HRP (Product # A28177, 1:10000 dilution) using the iBright™ FL1500 Imaging System (Product # A44115). Chemiluminescent detection was performed using SuperSignal™ West Atto Ultimate Sensitivity Substrate (Product # A38556).
Supportive validation
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- Immunofluorescence analysis of desmin was performed using 70% confluent log phase RD cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with Desmin Monoclonal Antibody (D33) (Product # MA5-13259) at 1:100 dilution in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Donkey anti-Mouse IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor Plus 488 (Product # A32766, 1:2000 dilution), for 45 minutes at room temperature (Panel a: Green). Nuclei (Panel b: Blue) were stained with ProLong™ Diamond Antifade Mountant with DAPI (Product # P36962). F-actin (Panel c: Red) was stained with Rhodamine Phalloidin (Product # R415, 1:300). Panel d represents the merged image showing cytoskeletal localization. Panel e represents MCF7 cells with no expression of Desmin. Panel f represents control cells with no primary antibody to assess background. The images were captured at 60X magnification.
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- Immunofluorescent analysis of Desmin (green) showing staining in the cytoplasm of human skeletal muscle (right) compared to a negative control without primary antibody (left). Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with a Desmin monoclonal antibody (Product # MA5-13259) in 3% BSA-PBS at a dilution of 1:20 and incubated overnight at 4ºC in a humidified chamber. Cells were washed with PBST and incubated with a DyLight-conjugated secondary antibody in PBS at room temperature in the dark. F-actin (red) was stained with a fluorescent red phalloidin and nuclei (blue) were stained with Hoechst or DAPI. Images were taken at a magnification of 60x.
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- Formalin-fixed, paraffin-embedded human leiomyoma stained with Desmin antibody using peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of muscle cells.
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- Formalin-fixed, paraffin-embedded rat bladder stained with Desmin antibody using peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of muscle cells.
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- Immunohistochemical analysis of desmin was performed using formalin-fixed paraffin-embedded human colon adenocarcinoma tissue sections. To expose the target protein, heat-induced epitope retrieval was performed on de-paraffinized sections using eBioscience™ IHC Antigen Retrieval Solution - Low pH (10X) (Product # 00-4955-58) diluted to 1X solution in water in a decloaking chamber at 110 degree Celsius for 15 minutes. Following antigen retrieval, the sections were blocked with 3% H2O2 for 1 h at toom temperature followed by 2% normal goat serum in 1X PBS for 45 minutes at room temperature. The sections were then probed with or without Desmin Monoclonal Antibody (D33) (Product # MA5-13259) at 1:5000 dilution in 0.1% normal goat serum overnight at 4 degree Celsius in a humidified chamber. Detection was performed using Alexa Fluor™ 647 Tyramide SuperBoost™ Kit, goat anti-mouse IgG (Product # B40916). Nuclei were stained with DAPI (Product # D1306) and the sections were mounted using ProLong™ Glass Antifade Mountant (Product # P36984). The images were captured on EVOS™ M7000 Imaging System (Product # AMF7000) at 20X magnification and externally deconvoluted.
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- Immunohistochemical analysis of desmin was performed using formalin-fixed paraffin-embedded human colon adenocarcinoma tissue sections. To expose the target protein, heat-induced epitope retrieval was performed on de-paraffinized sections using eBioscience™ IHC Antigen Retrieval Solution - Low pH (10X) (Product # 00-4955-58) diluted to 1X solution in water in a decloaking chamber at 110 degree Celsius for 15 minutes. Following antigen retrieval, the sections were blocked with 3% H2O2 for 1 h at toom temperature followed by 2% normal goat serum in 1X PBS for 45 minutes at room temperature. The sections were then probed with or without Desmin Monoclonal Antibody (D33) (Product # MA5-13259) at 1:5000 dilution in 0.1% normal goat serum overnight at 4 degree Celsius in a humidified chamber. Detection was performed using Alexa Fluor™ 647 Tyramide SuperBoost™ Kit, goat anti-mouse IgG (Product # B40916). Nuclei were stained with DAPI (Product # D1306) and the sections were mounted using ProLong™ Glass Antifade Mountant (Product # P36984). The images were captured on EVOS™ M7000 Imaging System (Product # AMF7000) at 20X magnification and externally deconvoluted.
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- Immunohistochemical analysis of desmin was performed using formalin-fixed paraffin-embedded human colon adenocarcinoma tissue sections. To expose the target protein, heat-induced epitope retrieval was performed on de-paraffinized sections using eBioscience™ IHC Antigen Retrieval Solution - Low pH (10X) (Product # 00-4955-58) diluted to 1X solution in water in a decloaking chamber at 110 degree Celsius for 15 minutes. Following antigen retrieval, the sections were blocked with 3% H2O2 for 1 h at toom temperature followed by 2% normal goat serum in 1X PBS for 45 minutes at room temperature. The sections were then probed with or without Desmin Monoclonal Antibody (D33) (Product # MA5-13259) at 1:5000 dilution in 0.1% normal goat serum overnight at 4 degree Celsius in a humidified chamber. Detection was performed using Alexa Fluor™ 647 Tyramide SuperBoost™ Kit, goat anti-mouse IgG (Product # B40916). Nuclei were stained with DAPI (Product # D1306) and the sections were mounted using ProLong™ Glass Antifade Mountant (Product # P36984). The images were captured on EVOS™ M7000 Imaging System (Product # AMF7000) at 20X magnification.
Supportive validation
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- Fig. 1 (A) Diffuse moderate immunolabeling for heat shock protein70 (HSP70) in cardiomyocytes of a control heart. (B) Dense immunolabeling of some foot-and-mouth disease virus (FMDV)-infected cardiomyocytes. Note the cytoplasmic and perinuclear (arrows). (C) Granularly sarcolemmal (arrowheads) and extracellular (arrows) localization of HSP70 immunolabeling. (D) alpha-BC immunolabeling in cross striations of cardiomyocytes in a control heart. (E) Abnormal accumulation of alpha-BC with coarse granules (arrows) in severely affected cardiomyocytes in a FMDV-infected heart. (F) Perinuclear localization of alpha-BC in the cross section of a FMDV-infected heart (arrows). (G) Desmin immunoreactivity in cross striations of cardiomyocytes from a control heart. (H) Abnormal distribution of desmin immunolabeling with a granular pattern in a FMDV-infected heart. Arrow indicates dense immunoreaction of Purkinje fibers. Immunohistochemical staining with streptavidin-biotin peroxidase complex (SABC) and 3-amino-9-ethylcarbazole (AEC), and counterstaining with Mayer's hematoxylin. A-D: x320, E and F: x160, G and H: x380.
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- FIGURE 1 p16 expression is down-regulated during HSC activation. (A,B) C57/BL6 mice were induced to develop liver fibrosis by CCl 4 injection and primary HSCs were isolated as described in Methods. P16 expression was examined by qPCR and Western. (C,D) C57/BL6 mice were induced to develop liver fibrosis by BDL and primary HSCs were isolated as described in Methods. P16 expression was examined by qPCR and Western. (E,F) Primary mouse HSCs were isolated from C57/BL6 mice and allowed to undergo spontaneous activation. The cells were harvested at day 2 and day 8 and p16 expression was examined by qPCR and Western. (G,H) LX-2 cells were treated with or without TGF-beta (10 ng/mL) for 48 h. P16 expression was examined by qPCR and Western. Data represent averages of three independent experiments and error bars represent SEM. * p
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- FIGURE 4 EPA, DPA, and DHA protect against the inhibitory effects of PAL on myotube differentiation. Protein expression of the myogenic protein myogenin 120 h following treatment with 500 muM PAL and/or 50 muM EPA, DPA, or DHA, with a representative image of a stain free blot used for normalization shown with molecular weight markers indicated (A) . Quantified protein expression of the myogenic protein myogenin (B) . All densitometry values are expressed relative to protein content determined by stain free imaging and presented in arbitrary units relative to CON. Treatments that do not share letters are considered statistically significant ( p < 0.05; n = 6 biological replicates). Average number of myotubes/field (C) and fusion index (number of nuclei in tubes relative to the total number of nuclei expressed as a percentage) (D) . Representative images of each treatment group at 120 h ( n = 3 biological replicates) (E) . Scale bar represents 275 mum. Values are presented as mean +- SEM.
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- Figure 1 Ventricular myocardium irradiated with 30 Gy at 4 weeks. Irradiated left ventricular free wall subendocardium of rats was stained with hematoxylin and eosin (H&E), Masson trichrome (MT), and immunohistochemistry (Desmin, TUNEL [terminal deoxynucleotidal transferase-mediated biotin-deoxyuridine triphosphate nick-end labeling] assay, and C4d immunostaining). Myocyte necrosis and apoptosis were not observed in rat hearts irradiated by 20 to 50 Gy. Intercellular space (interstitium) was widened but not fibrotic. Cellular rupture and destruction of myocytes were not observed. (x400 Magnification.)
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- Figure 4 Rdh10+/- (Het) males and females differ from each other and WT in muscle fiber characteristics. A , desmin immunostaining combined with DAPI staining of GM cryosections. The arrows denote centralized nuclei. Bars = 50 mum. Images were overexposed to allow visualization of nuclei. B , quantification of average number of fibers with centralized nuclei per field of view using H&E staining (averages of 3-48 sections from each of 3-4 mice), * p < 0.02. C , average CSA/mouse (1454-1635 individual fibers quantified for each sex and genotype). D and E , the ranges of the CSA frequency distribution of data in C .
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- 6 FIGURE Double whole-mount immunohistochemical stainings of the chicken thorax of HH-stage 24-30 using antibodies against Sox9 (green, left column) and Desmin (red, middle column) and overlays of both markers (right column). Dorsal is to the top and cranial is to the left, medial view. Sox9 is a marker of the chondrogenic lineage labelling the ribs, and Desmin is a marker of the myogenic lineage labelling musculature. Rib anlagen are numbered from Th1 to Th7. Arrowhead, intercostal muscle anlage. deg costal process and vertebral rib. + sternal rib. Abd, abdominal musculature before separation in anatomical muscle anlagen. Cs, costosternal muscle anlage; Iob, internal oblique abdominal muscle; Sm, putative anlage of the scalenus muscle; St, sternum; Tr, transverse abdominal muscle. Scale bar 500 mum.
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- 7 FIGURE Close-ups showing the differentiation front of ribs and intercostal muscles in the ventrolateral body wall. Double whole-mount immunohistochemical stainings of the chicken thorax of HH-stages 25-28 using antibodies against Sox9 (green) and Desmin (red) in an overlay of both markers in the same embryo. Dorsal is to the top and cranial is to the left, medial view. The left column (a-d) shows the original stainings, and the right column (a' to d') shows the identical specimens, with the outline of the rib and intercostal muscle anlagen drawn in for clarity. Note that the muscle anlagen extend more ventrally than the rib anlagen (a-c), and reach the same ventral level only at HH-stage 28 when both anlagen have reached the sternum (d). Arrowhead, distal tip of intercostal muscle anlagen showing loose and variable muscle fibres. Arrow, muscle fibres extending into the domain of the prospective rib anlage. deg, costal process and vertebral rib anlage. +, sternal rib anlage. St, sternal anlage. Scale bar 100 mum.
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- Impaired development of embryonic B cell bursa follicle. (A) Histological images of WT, RAG1 +/- , and RAG1 -/- E18 bursa. The number of follicles (B) and diameter (C) of bursa follicles within 1-fold of bursa. The significance of differences among groups was calculated by one-way ANOVA; ns, no significance, ** P < 0.01 and **** P < 0.0001. (D) Embryonic bursa sections were stained with desmin at E18 to identify bursa follicle compartmentalization.
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- 4 Figure Proliferation and inflammation of mesangial cells alleviated by cMet Ab treatment. A, Observation of cMet and desmin (a mesangial cells marker) expressions which are confirmed to merge well at the same site. Magnification: 800x (bar = 50 mum). B, Ki-67-positive cell expression and proliferation were increased after TNF-alpha stimulation and decreased dose-dependently after cMet Ab treatment. The data shown are representative of three independent experiments (N = 3/group; N = 5/group). Magnification: 400x (bar = 100 mum). C, Flow cytometry showed that the IL-8 + cells increased by approximately 1.7 times by TNF-alpha stimulation compared to the control. A dose-dependent decrease was observed on treatment with cMet Ab (N = 3/group). D, ICAM-1 expression was also increased on TNF-alpha stimulation; it was seen to reduce after cMet Ab treatment. Magnification: 800x (bar = 50 mum). The data shown are representative of three independent experiments. All data are presented as the mean +- SEM. * P < .05 (unpaired t test); ** P < .01 (unpaired t test); *** P < .001 (unpaired t test)