BS7952

antibody from Bioworld Technology, Inc
Targeting: UGT1A1 GNT1, UGT1, UGT1A
Provider product page for BS7952
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS7952 - Provider product page
Provider
Bioworld Technology, Inc
Product name
UGT1A1 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human UGT1A1.
Description
The human UDP-glucuronosyltransferase 1 (UGT1) locus encodes at least ten UGT1A proteins (UGT1A1-UGT1A10) that play a prominent role in drug and xenobiotic metabolism. Research indicates that nuclear receptors such as pregnane X receptor (PXR), constitutive androstane receptor (CAR) and peroxisome proliferator-activated receptor (PPAR) can regulate UGTs, which may contribute to the tissue-specific expression pattern of UGTs. Deficiency in the expression and/or activity of UGTs may lead to genetic and acquired diseases such as Crigler-Najjar syndrome and Gilbert syndrome. Based on their ability to catalyze the glucuronidation of xenobiotics and endobiotics, UGTs play a critical role in hormonal homeostasis, energy metabolism, bilirubin clearance and xenobiotic detoxification. UDP-glucuronosyltransferase 1A1 (UGT1A), also designated Bilirubin specific UDPGT isozyme 1 (HUG-BR1), is crucial in the conjugation and elimination of toxic zenobiotics and endogenous compounds. Defects in UGT1A1 may cause transient familial neonatal hyperbilirubinemia associated with breast milk, which is characterizied by excessive concentration of bilirubin in the blood, leading to jaundice.
Reactivity
Human
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
UGT1A1 protein structure - BS7952 shown in red.