Antibody data
- Antibody Data
- Antigen structure
- References [41]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
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Validation data
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- Product number
- 23660-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- Alpha Actin antibody
- Antibody type
- Polyclonal
- Description
- Alpha Actin antibody (Cat. #23660-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Chlorine disinfection elevates the toxicity of polystyrene microplastics to human cells by inducing mitochondria-dependent apoptosis.
Interactions between the ERK1/2 signaling pathway and PCAF play a key role in PE‑induced cardiomyocyte hypertrophy.
Diosgenin exerts anti-tumor effects through inactivation of cAMP/PKA/CREB signaling pathway in colorectal cancer.
A novel SIRT6 activator ameliorates neuroinflammation and ischemic brain injury via EZH2/FOXC1 axis.
PGC1α Promotes Cisplatin Resistance in Ovarian Cancer by Regulating the HSP70/HK2/VDAC1 Signaling Pathway.
Overexpression of retinoid X receptor beta provides protection against oxidized low-density lipoprotein-induced inflammation via regulating PGC1α-dependent mitochondrial homeostasis in endothelial cells.
Different roles of BAG3 in cardiac physiological hypertrophy and pathological remodeling.
Luteolin alleviates cognitive impairment in Alzheimer's disease mouse model via inhibiting endoplasmic reticulum stress-dependent neuroinflammation.
Betulinic acid attenuated bleomycin-induced pulmonary fibrosis by effectively intervening Wnt/β-catenin signaling.
USP15 participates in DBP-induced testicular oxidative stress injury through regulating the Keap1/Nrf2 signaling pathway.
Pygo1 regulates pathological cardiac hypertrophy via a β-catenin-dependent mechanism.
5-Azacytidine-Induced Cardiomyocyte Differentiation of Very Small Embryonic-Like Stem Cells.
Prognostic Significance and Related Mechanisms of Hexokinase 1 in Ovarian Cancer.
Evaluation of toxicity of halloysite nanotubes and multi-walled carbon nanotubes to endothelial cells in vitro and blood vessels in vivo.
USP22 promotes proliferation in renal cell carcinoma by stabilizing survivin.
Identification of miR-515-3p and its targets, vimentin and MMP3, as a key regulatory mechanism in esophageal cancer metastasis: functional and clinical significance.
The roles of dipeptidyl peptidase-4 and its inhibitors in the regulation of airway epithelial-mesenchymal transition.
Ginsenoside Rg3 promotes regression from hepatic fibrosis through reducing inflammation-mediated autophagy signaling pathway.
AMPK decreases ERK1/2 activity and cancer cell sensitivity to nutrition deprivation by mediating a positive feedback loop involving eEF2K.
Fucoxanthin inhibits hepatic oxidative stress, inflammation, and fibrosis in diet-induced nonalcoholic steatohepatitis model mice.
Moderate-Intensity Continuous Training Improves FGF21 and KLB Expression in Obese Mice.
CFIm25-regulated lncRNA acv3UTR promotes gastric tumorigenesis via miR-590-5p/YAP1 axis.
Therapeutic Effects of Human Urine-Derived Stem Cells in a Rat Model of Cisplatin-Induced Acute Kidney Injury In Vivo and In Vitro.
miR-30a-3p Targets MAD2L1 and Regulates Proliferation of Gastric Cancer Cells.
MicroRNA-92b-3p suppresses angiotensin II-induced cardiomyocyte hypertrophy via targeting HAND2.
CUDC-907 displays potent antitumor activity against human pancreatic adenocarcinoma in vitro and in vivo through inhibition of HDAC6 to downregulate c-Myc expression.
lncRNA TUG1 Promotes Cisplatin Resistance by Regulating CCND2 via Epigenetically Silencing miR-194-5p in Bladder Cancer.
Long noncoding RNA Neat1 modulates myogenesis by recruiting Ezh2.
Function of BRD4 in the pathogenesis of high glucose‑induced cardiac hypertrophy.
Epigallocatechin-3-gallate inhibits angiotensin II-induced cardiomyocyte hypertrophy via regulating Hippo signaling pathway in H9c2 rat cardiomyocytes.
Thioredoxin-interacting protein deficiency ameliorates kidney inflammation and fibrosis in mice with unilateral ureteral obstruction.
Gemin5 plays a role in unassembled-U1 snRNA disposal in SMN-deficient cells.
Dihydroartemisinin inhibits the viability of cervical cancer cells by upregulating caveolin 1 and mitochondrial carrier homolog 2: Involvement of p53 activation and NAD(P)H:quinone oxidoreductase 1 downregulation.
L-PGDS Mediates Vagus Nerve Stimulation-Induced Neuroprotection in a Rat Model of Ischemic Stroke by Suppressing the Apoptotic Response.
Overexpression of TRIB3 promotes angiogenesis in human gastric cancer.
Loss of Mouse P2Y6 Nucleotide Receptor Is Associated with Physiological Macrocardia and Amplified Pathological Cardiac Hypertrophy.
Vinexin β Interacts with Hepatitis C Virus NS5A, Modulating Its Hyperphosphorylation To Regulate Viral Propagation.
Transgenic mice overexpressing glia maturation factor-β, an oxidative stress inducible gene, show premature aging due to Zmpste24 down-regulation.
Actin-induced dimerization of palladin promotes actin-bundling.
DEAD-box RNA helicase DDX3X inhibits DENV replication via regulating type one interferon pathway.
Oncogenic miR-17/20a Forms a Positive Feed-forward Loop with the p53 Kinase DAPK3 to Promote Tumorigenesis.
Qin J, Xia PF, Yuan XZ, Wang SG
Journal of hazardous materials 2022 Mar 5;425:127842
Journal of hazardous materials 2022 Mar 5;425:127842
Interactions between the ERK1/2 signaling pathway and PCAF play a key role in PE‑induced cardiomyocyte hypertrophy.
Mao Q, Wu S, Peng C, Peng B, Luo X, Huang L, Zhang H
Molecular medicine reports 2021 Sep;24(3)
Molecular medicine reports 2021 Sep;24(3)
Diosgenin exerts anti-tumor effects through inactivation of cAMP/PKA/CREB signaling pathway in colorectal cancer.
Li SY, Shang J, Mao XM, Fan R, Li HQ, Li RH, Shen DY
European journal of pharmacology 2021 Oct 5;908:174370
European journal of pharmacology 2021 Oct 5;908:174370
A novel SIRT6 activator ameliorates neuroinflammation and ischemic brain injury via EZH2/FOXC1 axis.
He T, Shang J, Gao C, Guan X, Chen Y, Zhu L, Zhang L, Zhang C, Zhang J, Pang T
Acta pharmaceutica Sinica. B 2021 Mar;11(3):708-726
Acta pharmaceutica Sinica. B 2021 Mar;11(3):708-726
PGC1α Promotes Cisplatin Resistance in Ovarian Cancer by Regulating the HSP70/HK2/VDAC1 Signaling Pathway.
Li Y, Kang J, Fu J, Luo H, Liu Y, Li Y, Sun L
International journal of molecular sciences 2021 Mar 3;22(5)
International journal of molecular sciences 2021 Mar 3;22(5)
Overexpression of retinoid X receptor beta provides protection against oxidized low-density lipoprotein-induced inflammation via regulating PGC1α-dependent mitochondrial homeostasis in endothelial cells.
Zeng Y, Yan Wang C, Xu J, Le Xu X
Biochemical pharmacology 2021 Jun;188:114559
Biochemical pharmacology 2021 Jun;188:114559
Different roles of BAG3 in cardiac physiological hypertrophy and pathological remodeling.
Jia P, Wu N, Yang H, Guo Y, Guo X, Sun Y
Translational research : the journal of laboratory and clinical medicine 2021 Jul;233:47-61
Translational research : the journal of laboratory and clinical medicine 2021 Jul;233:47-61
Luteolin alleviates cognitive impairment in Alzheimer's disease mouse model via inhibiting endoplasmic reticulum stress-dependent neuroinflammation.
Kou JJ, Shi JZ, He YY, Hao JJ, Zhang HY, Luo DM, Song JK, Yan Y, Xie XM, Du GH, Pang XB
Acta pharmacologica Sinica 2021 Jul 15;
Acta pharmacologica Sinica 2021 Jul 15;
Betulinic acid attenuated bleomycin-induced pulmonary fibrosis by effectively intervening Wnt/β-catenin signaling.
Li X, Liu X, Deng R, Gao S, Jiang Q, Liu R, Li H, Miao Y, Zhai Y, Zhang S, Wang Z, Ren Y, Ning W, Zhou H, Yang C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Jan;81:153428
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Jan;81:153428
USP15 participates in DBP-induced testicular oxidative stress injury through regulating the Keap1/Nrf2 signaling pathway.
Zhang L, Gao X, Qin Z, Shi X, Xu K, Wang S, Tang M, Wang W, Gao S, Zuo L, Zhang L, Zhang W
The Science of the total environment 2021 Aug 20;783:146898
The Science of the total environment 2021 Aug 20;783:146898
Pygo1 regulates pathological cardiac hypertrophy via a β-catenin-dependent mechanism.
Lin L, Xu W, Li Y, Zhu P, Yuan W, Liu M, Shi Y, Chen Y, Liang J, Chen J, Yang B, Cai W, Wen Y, Zhu X, Peng X, Zhou Z, Mo X, Wan Y, Yuan H, Li F, Ye X, Jiang Z, Wang Y, Zhuang J, Fan X, Wu X
American journal of physiology. Heart and circulatory physiology 2021 Apr 1;320(4):H1634-H1645
American journal of physiology. Heart and circulatory physiology 2021 Apr 1;320(4):H1634-H1645
5-Azacytidine-Induced Cardiomyocyte Differentiation of Very Small Embryonic-Like Stem Cells.
Sun X, Li H, Zhu Y, Xu P, Zuo Q, Li B, Gu X
Stem cells international 2020;2020:5162350
Stem cells international 2020;2020:5162350
Prognostic Significance and Related Mechanisms of Hexokinase 1 in Ovarian Cancer.
Li Y, Tian H, Luo H, Fu J, Jiao Y, Li Y
OncoTargets and therapy 2020;13:11583-11594
OncoTargets and therapy 2020;13:11583-11594
Evaluation of toxicity of halloysite nanotubes and multi-walled carbon nanotubes to endothelial cells in vitro and blood vessels in vivo.
Wu B, Jiang M, Liu X, Huang C, Gu Z, Cao Y
Nanotoxicology 2020 Oct;14(8):1017-1038
Nanotoxicology 2020 Oct;14(8):1017-1038
USP22 promotes proliferation in renal cell carcinoma by stabilizing survivin.
Lin Y, Zhong H, Sun B, Peng Y, Lu F, Chen M, Zhu M, Huang J
Oncology letters 2020 Nov;20(5):246
Oncology letters 2020 Nov;20(5):246
Identification of miR-515-3p and its targets, vimentin and MMP3, as a key regulatory mechanism in esophageal cancer metastasis: functional and clinical significance.
Hu HF, Xu WW, Zhang WX, Yan X, Li YJ, Li B, He QY
Signal transduction and targeted therapy 2020 Nov 27;5(1):271
Signal transduction and targeted therapy 2020 Nov 27;5(1):271
The roles of dipeptidyl peptidase-4 and its inhibitors in the regulation of airway epithelial-mesenchymal transition.
Sun J, Chu S, Lu M, Pan Q, Li D, Zheng S, Ma L
Experimental lung research 2020 May - Aug;46(6):163-173
Experimental lung research 2020 May - Aug;46(6):163-173
Ginsenoside Rg3 promotes regression from hepatic fibrosis through reducing inflammation-mediated autophagy signaling pathway.
Liu X, Mi X, Wang Z, Zhang M, Hou J, Jiang S, Wang Y, Chen C, Li W
Cell death & disease 2020 Jun 12;11(6):454
Cell death & disease 2020 Jun 12;11(6):454
AMPK decreases ERK1/2 activity and cancer cell sensitivity to nutrition deprivation by mediating a positive feedback loop involving eEF2K.
Tong S, Zhou T, Meng Y, Xu D, Chen J
Oncology letters 2020 Jul;20(1):61-66
Oncology letters 2020 Jul;20(1):61-66
Fucoxanthin inhibits hepatic oxidative stress, inflammation, and fibrosis in diet-induced nonalcoholic steatohepatitis model mice.
Takatani N, Kono Y, Beppu F, Okamatsu-Ogura Y, Yamano Y, Miyashita K, Hosokawa M
Biochemical and biophysical research communications 2020 Jul 23;528(2):305-310
Biochemical and biophysical research communications 2020 Jul 23;528(2):305-310
Moderate-Intensity Continuous Training Improves FGF21 and KLB Expression in Obese Mice.
Xiong Y, Chen Y, Liu Y, Zhang B
Biochemistry. Biokhimiia 2020 Aug;85(8):938-946
Biochemistry. Biokhimiia 2020 Aug;85(8):938-946
CFIm25-regulated lncRNA acv3UTR promotes gastric tumorigenesis via miR-590-5p/YAP1 axis.
Liu K, Wang BJ, Han W, Chi CH, Gu C, Wang Y, Fu X, Huang W, Liu Z, Song X
Oncogene 2020 Apr;39(15):3075-3088
Oncogene 2020 Apr;39(15):3075-3088
Therapeutic Effects of Human Urine-Derived Stem Cells in a Rat Model of Cisplatin-Induced Acute Kidney Injury In Vivo and In Vitro.
Sun B, Luo X, Yang C, Liu P, Yang Y, Dong X, Yang Z, Xu J, Zhang Y, Li L
Stem cells international 2019;2019:8035076
Stem cells international 2019;2019:8035076
miR-30a-3p Targets MAD2L1 and Regulates Proliferation of Gastric Cancer Cells.
Wang Y, Wang F, He J, Du J, Zhang H, Shi H, Chen Y, Wei Y, Xue W, Yan J, Feng Y, Gao Y, Li D, Han J, Zhang J
OncoTargets and therapy 2019;12:11313-11324
OncoTargets and therapy 2019;12:11313-11324
MicroRNA-92b-3p suppresses angiotensin II-induced cardiomyocyte hypertrophy via targeting HAND2.
Yu XJ, Huang YQ, Shan ZX, Zhu JN, Hu ZQ, Huang L, Feng YQ, Geng QS
Life sciences 2019 Sep 1;232:116635
Life sciences 2019 Sep 1;232:116635
CUDC-907 displays potent antitumor activity against human pancreatic adenocarcinoma in vitro and in vivo through inhibition of HDAC6 to downregulate c-Myc expression.
Fu XH, Zhang X, Yang H, Xu XW, Hu ZL, Yan J, Zheng XL, Wei RR, Zhang ZQ, Tang SR, Geng MY, Huang X
Acta pharmacologica Sinica 2019 May;40(5):677-688
Acta pharmacologica Sinica 2019 May;40(5):677-688
lncRNA TUG1 Promotes Cisplatin Resistance by Regulating CCND2 via Epigenetically Silencing miR-194-5p in Bladder Cancer.
Yu G, Zhou H, Yao W, Meng L, Lang B
Molecular therapy. Nucleic acids 2019 Jun 7;16:257-271
Molecular therapy. Nucleic acids 2019 Jun 7;16:257-271
Long noncoding RNA Neat1 modulates myogenesis by recruiting Ezh2.
Wang S, Zuo H, Jin J, Lv W, Xu Z, Fan Y, Zhang J, Zuo B
Cell death & disease 2019 Jun 26;10(7):505
Cell death & disease 2019 Jun 26;10(7):505
Function of BRD4 in the pathogenesis of high glucose‑induced cardiac hypertrophy.
Wang Q, Sun Y, Li T, Liu L, Zhao Y, Li L, Zhang L, Meng Y
Molecular medicine reports 2019 Jan;19(1):499-507
Molecular medicine reports 2019 Jan;19(1):499-507
Epigallocatechin-3-gallate inhibits angiotensin II-induced cardiomyocyte hypertrophy via regulating Hippo signaling pathway in H9c2 rat cardiomyocytes.
Ma Y, Hu Y, Wu J, Wen J, Li S, Zhang L, Zhang J, Li Y, Li J
Acta biochimica et biophysica Sinica 2019 Apr 1;51(4):422-430
Acta biochimica et biophysica Sinica 2019 Apr 1;51(4):422-430
Thioredoxin-interacting protein deficiency ameliorates kidney inflammation and fibrosis in mice with unilateral ureteral obstruction.
Wu M, Li R, Hou Y, Song S, Han W, Chen N, Du Y, Ren Y, Shi Y
Laboratory investigation; a journal of technical methods and pathology 2018 Sep;98(9):1211-1224
Laboratory investigation; a journal of technical methods and pathology 2018 Sep;98(9):1211-1224
Gemin5 plays a role in unassembled-U1 snRNA disposal in SMN-deficient cells.
Jiang D, Zou X, Zhang C, Chen J, Li Z, Wang Y, Deng Z, Wang L, Chen S
FEBS letters 2018 Apr;592(8):1400-1411
FEBS letters 2018 Apr;592(8):1400-1411
Dihydroartemisinin inhibits the viability of cervical cancer cells by upregulating caveolin 1 and mitochondrial carrier homolog 2: Involvement of p53 activation and NAD(P)H:quinone oxidoreductase 1 downregulation.
Zhang T, Hu Y, Wang T, Cai P
International journal of molecular medicine 2017 Jul;40(1):21-30
International journal of molecular medicine 2017 Jul;40(1):21-30
L-PGDS Mediates Vagus Nerve Stimulation-Induced Neuroprotection in a Rat Model of Ischemic Stroke by Suppressing the Apoptotic Response.
Zhang L, Ma J, Jin X, Jia G, Jiang Y, Li C
Neurochemical research 2017 Feb;42(2):644-655
Neurochemical research 2017 Feb;42(2):644-655
Overexpression of TRIB3 promotes angiogenesis in human gastric cancer.
Dong S, Xia J, Wang H, Sun L, Wu Z, Bin J, Liao Y, Li N, Liao W
Oncology reports 2016 Oct;36(4):2339-48
Oncology reports 2016 Oct;36(4):2339-48
Loss of Mouse P2Y6 Nucleotide Receptor Is Associated with Physiological Macrocardia and Amplified Pathological Cardiac Hypertrophy.
Clouet S, Di Pietrantonio L, Daskalopoulos EP, Esfahani H, Horckmans M, Vanorlé M, Lemaire A, Balligand JL, Beauloye C, Boeynaems JM, Communi D
The Journal of biological chemistry 2016 Jul 22;291(30):15841-52
The Journal of biological chemistry 2016 Jul 22;291(30):15841-52
Vinexin β Interacts with Hepatitis C Virus NS5A, Modulating Its Hyperphosphorylation To Regulate Viral Propagation.
Xiong W, Yang J, Wang M, Wang H, Rao Z, Zhong C, Xin X, Mo L, Yu S, Shen C, Zheng C
Journal of virology 2015 Jul;89(14):7385-400
Journal of virology 2015 Jul;89(14):7385-400
Transgenic mice overexpressing glia maturation factor-β, an oxidative stress inducible gene, show premature aging due to Zmpste24 down-regulation.
Imai R, Asai K, Hanai J, Takenaka M
Aging 2015 Jul;7(7):486-99
Aging 2015 Jul;7(7):486-99
Actin-induced dimerization of palladin promotes actin-bundling.
Vattepu R, Yadav R, Beck MR
Protein science : a publication of the Protein Society 2015 Jan;24(1):70-80
Protein science : a publication of the Protein Society 2015 Jan;24(1):70-80
DEAD-box RNA helicase DDX3X inhibits DENV replication via regulating type one interferon pathway.
Li G, Feng T, Pan W, Shi X, Dai J
Biochemical and biophysical research communications 2015 Jan 2;456(1):327-32
Biochemical and biophysical research communications 2015 Jan 2;456(1):327-32
Oncogenic miR-17/20a Forms a Positive Feed-forward Loop with the p53 Kinase DAPK3 to Promote Tumorigenesis.
Cai Z, Cao R, Zhang K, Xue Y, Zhang C, Zhou Y, Zhou J, Sun H, Fu XD
The Journal of biological chemistry 2015 Aug 7;290(32):19967-75
The Journal of biological chemistry 2015 Aug 7;290(32):19967-75
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- rat skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 23660-1-AP( ACTA1 Antibody) at dilution of 1:4000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Alpha Actin antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human Alpha Actin. This antibody recognizes human, mouse, rat antigen. The Alpha Actin antibody has been validated for the following applications: ELISA, WB, IHC, IF analysis.