Explore
Validate
Learn
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [24]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 10757-2-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10757-2-AP, RRID:AB_2289488
- Product name
- AHCY antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated AHCY antibody (Cat. #10757-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Effects of H19/SAHH/DNMT1 on the oxidative DNA damage related to benzo[a]pyrene exposure.
Single-cell RNA-seq reveals novel immune-associated biomarkers for predicting prognosis in AML patients with RUNX1::RUNX1T1.
Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target.
The long non-coding RNA lncMYOZ2 mediates an AHCY/MYOZ2 axis to promote adipogenic differentiation in porcine preadipocytes.
AHCYL1 senses SAH to inhibit autophagy through interaction with PIK3C3 in an MTORC1-independent manner.
Insufficient S-adenosylhomocysteine hydrolase compromises the beneficial effect of diabetic BMSCs on diabetic cardiomyopathy.
Excess S-adenosylmethionine inhibits methylation via catabolism to adenine.
Linkage of methionine addiction, histone lysine hypermethylation, and malignancy.
Novel candidate factors predicting the effect of S-1 adjuvant chemotherapy of pancreatic cancer.
Disrupting Mitochondrial Copper Distribution Inhibits Leukemic Stem Cell Self-Renewal.
Identification of Serum Biomarkers to Distinguish Hazardous and Benign Aminotransferase Elevations.
Integrated Metabolomics and Network Pharmacology Approach to Explain Possible Action Mechanisms of Xin-Sheng-Hua Granule for Treating Anemia.
LncRNA H19 interacts with S-adenosylhomocysteine hydrolase to regulate LINE-1 Methylation in human lung-derived cells exposed to Benzo[a]pyrene.
Ligustrazine modulates renal cysteine biosynthesis in rats exposed to cadmium.
Metformin alters DNA methylation genome-wide via the H19/SAHH axis.
Increased plasma S-adenosylhomocysteine-accelerated atherosclerosis is associated with epigenetic regulation of endoplasmic reticulum stress in apoE-/- mice.
H19 lncRNA alters DNA methylation genome wide by regulating S-adenosylhomocysteine hydrolase.
Overexpression of S-adenosylhomocysteine hydrolase (SAHH) in esophageal squamous cell carcinoma (ESCC) cell lines: effects on apoptosis, migration and adhesion of cells.
Altered dietary methionine differentially impacts glutathione and methionine metabolism in long-living growth hormone-deficient Ames dwarf and wild-type mice.
Digital transcript profile analysis with aRNA-LongSAGE validates FERMT1 as a potential novel prognostic marker for colon cancer.
Identification of S100A8 and S100A9 as serological markers for colorectal cancer.
Regulation of homocysteine homeostasis through the transcriptional coactivator PGC-1alpha.
Characterization, expression and localization of S-adenosylhomocysteine hydrolase from amphioxus Branchiostoma belcheri tsingtaunese.
Interplay between cellular methyl metabolism and adaptive efflux during oncogenic transformation from chronic arsenic exposure in human cells.
Fu Y, Li X, Pan B, Niu Y, Zhang B, Zhao X, Nie J, Yang J
Environmental science and pollution research international 2023 Jan;30(5):11706-11718
Environmental science and pollution research international 2023 Jan;30(5):11706-11718
Single-cell RNA-seq reveals novel immune-associated biomarkers for predicting prognosis in AML patients with RUNX1::RUNX1T1.
Li XP, Dai Y, Zhang WN, Pan MM, Mao J, Zhao B, Jiang L, Gao Y
International immunopharmacology 2023 Dec;125(Pt B):111178
International immunopharmacology 2023 Dec;125(Pt B):111178
Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target.
Vande Voorde J, Steven RT, Najumudeen AK, Ford CA, Dexter A, Gonzalez-Fernandez A, Nikula CJ, Xiang Y, Ford L, Maneta Stavrakaki S, Gilroy K, Zeiger LB, Pennel K, Hatthakarnkul P, Elia EA, Nasif A, Murta T, Manoli E, Mason S, Gillespie M, Lannagan TRM, Vlahov N, Ridgway RA, Nixon C, Raven A, Mills M, Athineos D, Kanellos G, Nourse C, Gay DM, Hughes M, Burton A, Yan B, Sellers K, Wu V, De Ridder K, Shokry E, Huerta Uribe A, Clark W, Clark G, Kirschner K, Thienpont B, Li VSW, Maddocks ODK, Barry ST, Goodwin RJA, Kinross J, Edwards J, Yuneva MO, Sumpton D, Takats Z, Campbell AD, Bunch J, Sansom OJ
Nature metabolism 2023 Aug;5(8):1303-1318
Nature metabolism 2023 Aug;5(8):1303-1318
The long non-coding RNA lncMYOZ2 mediates an AHCY/MYOZ2 axis to promote adipogenic differentiation in porcine preadipocytes.
Yang Y, Wu Y, Ji M, Rong X, Zhang Y, Yang S, Lu C, Cai C, Gao P, Guo X, Li B, Cao G
BMC genomics 2022 Oct 11;23(1):700
BMC genomics 2022 Oct 11;23(1):700
AHCYL1 senses SAH to inhibit autophagy through interaction with PIK3C3 in an MTORC1-independent manner.
Huang W, Li N, Zhang Y, Wang X, Yin M, Lei QY
Autophagy 2022 Feb;18(2):309-319
Autophagy 2022 Feb;18(2):309-319
Insufficient S-adenosylhomocysteine hydrolase compromises the beneficial effect of diabetic BMSCs on diabetic cardiomyopathy.
Wang Y, Zhang Y, Chen K, Liu J, Wu D, Cheng Y, Wang H, Li Y
Stem cell research & therapy 2022 Aug 13;13(1):418
Stem cell research & therapy 2022 Aug 13;13(1):418
Excess S-adenosylmethionine inhibits methylation via catabolism to adenine.
Fukumoto K, Ito K, Saer B, Taylor G, Ye S, Yamano M, Toriba Y, Hayes A, Okamura H, Fustin JM
Communications biology 2022 Apr 5;5(1):313
Communications biology 2022 Apr 5;5(1):313
Linkage of methionine addiction, histone lysine hypermethylation, and malignancy.
Yamamoto J, Inubushi S, Han Q, Tashiro Y, Sugisawa N, Hamada K, Aoki Y, Miyake K, Matsuyama R, Bouvet M, Clarke SG, Endo I, Hoffman RM
iScience 2022 Apr 15;25(4):104162
iScience 2022 Apr 15;25(4):104162
Novel candidate factors predicting the effect of S-1 adjuvant chemotherapy of pancreatic cancer.
Mitachi K, Ariake K, Shima H, Sato S, Miura T, Maeda S, Ishida M, Mizuma M, Ohtsuka H, Kamei T, Igarashi K, Unno M
Scientific reports 2021 Mar 22;11(1):6541
Scientific reports 2021 Mar 22;11(1):6541
Disrupting Mitochondrial Copper Distribution Inhibits Leukemic Stem Cell Self-Renewal.
Singh RP, Jeyaraju DV, Voisin V, Hurren R, Xu C, Hawley JR, Barghout SH, Khan DH, Gronda M, Wang X, Jitkova Y, Sharon D, Liyanagae S, MacLean N, Seneviratene AK, Mirali S, Borenstein A, Thomas GE, Soriano J, Orouji E, Minden MD, Arruda A, Chan SM, Bader GD, Lupien M, Schimmer AD
Cell stem cell 2020 Jun 4;26(6):926-937.e10
Cell stem cell 2020 Jun 4;26(6):926-937.e10
Identification of Serum Biomarkers to Distinguish Hazardous and Benign Aminotransferase Elevations.
Vazquez JH, Clemens MM, Allard FD, Yee EU, Kennon-McGill S, Mackintosh SG, Jaeschke H, Hambuchen MD, McGill MR
Toxicological sciences : an official journal of the Society of Toxicology 2020 Feb 1;173(2):244-254
Toxicological sciences : an official journal of the Society of Toxicology 2020 Feb 1;173(2):244-254
Integrated Metabolomics and Network Pharmacology Approach to Explain Possible Action Mechanisms of Xin-Sheng-Hua Granule for Treating Anemia.
Pang HQ, Yue SJ, Tang YP, Chen YY, Tan YJ, Cao YJ, Shi XQ, Zhou GS, Kang A, Huang SL, Shi YJ, Sun J, Tang ZS, Duan JA
Frontiers in pharmacology 2018;9:165
Frontiers in pharmacology 2018;9:165
LncRNA H19 interacts with S-adenosylhomocysteine hydrolase to regulate LINE-1 Methylation in human lung-derived cells exposed to Benzo[a]pyrene.
Fu Y, Wang W, Li X, Liu Y, Niu Y, Zhang B, Nie J, Pan B, Wang R, Yang J
Chemosphere 2018 Sep;207:84-90
Chemosphere 2018 Sep;207:84-90
Ligustrazine modulates renal cysteine biosynthesis in rats exposed to cadmium.
Kuang W, Zhang X, Zhu W, Lan Z
Environmental toxicology and pharmacology 2017 Sep;54:125-132
Environmental toxicology and pharmacology 2017 Sep;54:125-132
Metformin alters DNA methylation genome-wide via the H19/SAHH axis.
Zhong T, Men Y, Lu L, Geng T, Zhou J, Mitsuhashi A, Shozu M, Maihle NJ, Carmichael GG, Taylor HS, Huang Y
Oncogene 2017 Apr 27;36(17):2345-2354
Oncogene 2017 Apr 27;36(17):2345-2354
Increased plasma S-adenosylhomocysteine-accelerated atherosclerosis is associated with epigenetic regulation of endoplasmic reticulum stress in apoE-/- mice.
Xiao Y, Huang W, Zhang J, Peng C, Xia M, Ling W
Arteriosclerosis, thrombosis, and vascular biology 2015 Jan;35(1):60-70
Arteriosclerosis, thrombosis, and vascular biology 2015 Jan;35(1):60-70
H19 lncRNA alters DNA methylation genome wide by regulating S-adenosylhomocysteine hydrolase.
Zhou J, Yang L, Zhong T, Mueller M, Men Y, Zhang N, Xie J, Giang K, Chung H, Sun X, Lu L, Carmichael GG, Taylor HS, Huang Y
Nature communications 2015 Dec 21;6:10221
Nature communications 2015 Dec 21;6:10221
Overexpression of S-adenosylhomocysteine hydrolase (SAHH) in esophageal squamous cell carcinoma (ESCC) cell lines: effects on apoptosis, migration and adhesion of cells.
Li Q, Mao L, Wang R, Zhu L, Xue L
Molecular biology reports 2014;41(4):2409-17
Molecular biology reports 2014;41(4):2409-17
Altered dietary methionine differentially impacts glutathione and methionine metabolism in long-living growth hormone-deficient Ames dwarf and wild-type mice.
Brown-Borg HM, Rakoczy S, Wonderlich JA, Armstrong V, Rojanathammanee L
Longevity & healthspan 2014;3(1):10
Longevity & healthspan 2014;3(1):10
Digital transcript profile analysis with aRNA-LongSAGE validates FERMT1 as a potential novel prognostic marker for colon cancer.
Fan J, Yan D, Teng M, Tang H, Zhou C, Wang X, Li D, Qiu G, Peng Z
Clinical cancer research : an official journal of the American Association for Cancer Research 2011 May 1;17(9):2908-18
Clinical cancer research : an official journal of the American Association for Cancer Research 2011 May 1;17(9):2908-18
Identification of S100A8 and S100A9 as serological markers for colorectal cancer.
Kim HJ, Kang HJ, Lee H, Lee ST, Yu MH, Kim H, Lee C
Journal of proteome research 2009 Mar;8(3):1368-79
Journal of proteome research 2009 Mar;8(3):1368-79
Regulation of homocysteine homeostasis through the transcriptional coactivator PGC-1alpha.
Li S, Arning E, Liu C, Vitvitsky V, Hernandez C, Banerjee R, Bottiglieri T, Lin JD
American journal of physiology. Endocrinology and metabolism 2009 Mar;296(3):E543-8
American journal of physiology. Endocrinology and metabolism 2009 Mar;296(3):E543-8
Characterization, expression and localization of S-adenosylhomocysteine hydrolase from amphioxus Branchiostoma belcheri tsingtaunese.
Wang Y, Zhao B, Zhang S, Qu X
Bioscience reports 2008 Jun;28(3):135-44
Bioscience reports 2008 Jun;28(3):135-44
Interplay between cellular methyl metabolism and adaptive efflux during oncogenic transformation from chronic arsenic exposure in human cells.
Coppin JF, Qu W, Waalkes MP
The Journal of biological chemistry 2008 Jul 11;283(28):19342-50
The Journal of biological chemistry 2008 Jul 11;283(28):19342-50
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse thymus tissue were subjected to SDS PAGE followed by western blot with 10757-2-AP(AHCY antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The AHCY antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human AHCY. This antibody recognizes human,mouse,rat antigen. The AHCY antibody has been validated for the following applications: ELISA, WB, IHC analysis.
