MA5-12407

antibody from Invitrogen Antibodies

Targeting: CD68 DKFZp686M18236, GP110, LAMP4, macrosialin, SCARD1

Immunohistochemistry (Supportive data in Antibodypedia)

Other assay (Supportive data in Antibodypedia)

Antibody Data

Product number

MA5-12407

Provider

Invitrogen Antibodies

Product name

CD68 Monoclonal Antibody (PG-M1)

Antibody type

Monoclonal

Antigen

Other

Description

MA5-12407 targets CD68 in IHC (P) applications and shows reactivity with Human samples.

Antibody clone number

PG-M1

Concentration

Conc. Not Determined

References

Submitted references

Combination immunotherapy with nivolumab and ipilimumab in patients with rare gynecological malignancies: results of the CA209-538 clinical trial.

Klein O, Kee D, Gao B, Markman B, da Gama Duarte J, Quigley L, Jackett L, Linklater R, Strickland A, Scott C, Mileshkin L, Palmer J, Carlino M, Behren A, Cebon J
Journal for immunotherapy of cancer 2021 Nov;9(11)

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Tryptophan 2,3-Dioxygenase Expression Identified in Human Hepatocellular Carcinoma Cells and in Intratumoral Pericytes of Most Cancers.

Hoffmann D, Dvorakova T, Stroobant V, Bouzin C, Daumerie A, Solvay M, Klaessens S, Letellier MC, Renauld JC, van Baren N, Lelotte J, Marbaix E, Van den Eynde BJ
Cancer immunology research 2020 Jan;8(1):19-31

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The role of ADAM-like decysin 1 in non-eosinophilic chronic rhinosinusitis with nasal polyps.

Sugimoto N, Nakayama T, Kasai Y, Asaka D, Mitsuyoshi R, Tsurumoto T, Takaishi S, Omae S, Kojima H, Tanaka Y, Haruna SI
Acta oto-laryngologica 2018 Sep;138(9):830-836

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Effects of Electrochemotherapy with Cisplatin and Peritumoral IL-12 Gene Electrotransfer on Canine Mast Cell Tumors: a Histopathologic and Immunohistochemical Study.

Salvadori C, Svara T, Rocchigiani G, Millanta F, Pavlin D, Cemazar M, Lampreht Tratar U, Sersa G, Tozon N, Poli A
Radiology and oncology 2017 Sep;51(3):286-294

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Neutrophils are a major source of the epithelial barrier disrupting cytokine oncostatin M in patients with mucosal airways disease.

Pothoven KL, Norton JE, Suh LA, Carter RG, Harris KE, Biyasheva A, Welch K, Shintani-Smith S, Conley DB, Liu MC, Kato A, Avila PC, Hamid Q, Grammer LC 3rd, Peters AT, Kern RC, Tan BK, Schleimer RP
The Journal of allergy and clinical immunology 2017 Jun;139(6):1966-1978.e9

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Novel role for IL-22 in protection during chronic Mycobacterium tuberculosis HN878 infection.

Treerat P, Prince O, Cruz-Lagunas A, Muñoz-Torrico M, Salazar-Lezama MA, Selman M, Fallert-Junecko B, Reinhardt TA, Alcorn JF, Kaushal D, Zuñiga J, Rangel-Moreno J, Kolls JK, Khader SA
Mucosal immunology 2017 Jul;10(4):1069-1081

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Fibroblastic reticular cell tumor of the breast: A case report and review of the literature.

Li H, Shen P, Liang Y, Zhang F
Experimental and therapeutic medicine 2016 Feb;11(2):561-564

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Diagnostic and therapeutic strategy and the most efficient prognostic factors of breast malignant fibrous histiocytoma.

Qiu SQ, Wei XL, Huang WH, Wu MY, Qin YS, Li YK, Zhang GJ
Scientific reports 2013;3:2529

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Secreted proteins from carotid endarterectomy: an untargeted approach to disclose molecular clues of plaque progression.

Rocchiccioli S, Pelosi G, Rosini S, Marconi M, Viglione F, Citti L, Ferrari M, Trivella MG, Cecchettini A
Journal of translational medicine 2013 Oct 16;11:260

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CCAAT/enhancer binding protein δ in macrophages contributes to immunosuppression and inhibits phagocytosis in nasopharyngeal carcinoma.

Hsiao YW, Li CF, Chi JY, Tseng JT, Chang Y, Hsu LJ, Lee CH, Chang TH, Wang SM, Wang DD, Cheng HC, Wang JM
Science signaling 2013 Jul 16;6(284):ra59

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Increased expression of CC chemokine ligand 18 in patients with chronic rhinosinusitis with nasal polyps.

Peterson S, Poposki JA, Nagarkar DR, Chustz RT, Peters AT, Suh LA, Carter R, Norton J, Harris KE, Grammer LC, Tan BK, Chandra RK, Conley DB, Kern RC, Schleimer RP, Kato A
The Journal of allergy and clinical immunology 2012 Jan;129(1):119-27.e1-9

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Sporadic haemangioblastoma of the kidney with rhabdoid features and focal CD10 expression: report of a case and literature review.

Yin WH, Li J, Chan JK
Diagnostic pathology 2012 Apr 12;7:39

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Intratumoral Immune Responses Can Distinguish New Primary and True Recurrence Types of Ipsilateral Breast Tumor Recurrences (IBTR).

West NR, Panet-Raymond V, Truong PT, Alexander C, Babinszky S, Milne K, Ross LA, Loken S, Watson PH
Breast cancer : basic and clinical research 2011;5:105-15

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Increased expression of the chemokine CCL23 in eosinophilic chronic rhinosinusitis with nasal polyps.

Poposki JA, Uzzaman A, Nagarkar DR, Chustz RT, Peters AT, Suh LA, Carter R, Norton J, Harris KE, Grammer LC, Tan BK, Chandra RK, Conley DB, Kern RC, Schleimer RP, Kato A
The Journal of allergy and clinical immunology 2011 Jul;128(1):73-81.e4

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Giant cell tumor-like lesion of the urinary bladder: a report of two cases and literature review; giant cell tumor or undifferentiated carcinoma?

Behzatoğlu K, Durak H, Canberk S, Aydin O, Huq GE, Oznur M, Ozyalvaçli G, Yildiz P
Diagnostic pathology 2009 Dec 31;4:48

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Microinflammation is involved in the dysfunction of arteriovenous fistula in patients with maintenance hemodialysis.

Liu BC, Li L, Gao M, Wang YL, Yu JR
Chinese medical journal 2008 Nov 5;121(21):2157-61

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Glomeruloid hemangioma.

Yuri T, Yamazaki F, Takasu K, Shikata N, Tsubura A
Pathology international 2008 Jun;58(6):390-5

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Macrophages, inflammation and risk of cervical intraepithelial neoplasia (CIN) progression--clinicopathological correlation.

Hammes LS, Tekmal RR, Naud P, Edelweiss MI, Kirma N, Valente PT, Syrjänen KJ, Cunha-Filho JS
Gynecologic oncology 2007 Apr;105(1):157-65

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Inhibition of AIF-1 expression by constitutive siRNA expression reduces macrophage migration, proliferation, and signal transduction initiated by atherogenic stimuli.

Tian Y, Kelemen SE, Autieri MV
American journal of physiology. Cell physiology 2006 Apr;290(4):C1083-91

Immunohistochemistry

Supportive validation

Submitted by

Invitrogen Antibodies (provider)

Main image

Experimental details

Formalin-fixed, paraffin-embedded human tonsil stained with CD68 using peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of macrophage

Supportive validation

Submitted by

Invitrogen Antibodies (provider)

Main image

Experimental details

Formalin-fixed, paraffin-embedded human tonsil stained with CD68 using peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of macrophage

Other assay

Supportive validation

Submitted by

Invitrogen Antibodies (provider)

Main image

Experimental details

Figure 2 Left: P and DS sections stained with (a) Masson's trichrome stain, (b) alpha-SMA and (c) CD68 immunostain (original magnification 2x , insets 10x ). P is a type VI plaque with a necrotic core, calcifications, intraplaque thrombus and a thin fibrous cap composed of collagen and alphaSM-actin positive cells; minor intraplaque CD68 positive staining is present and alpha-SMA -actin positive contractile VSMCs are also visible on the outer border of the specimen (opposite to the lumen) due to surgical cleavage of plaque from the intact tunica media. In DS, a much thinner lesion (equivalent to Stary type III) with extensive alpha -SMA and CD68 cellular positivity is present. Right: From top to bottom. Average values and SD of lesional area (mm 2 ), intralesional alpha-SMA and CD68 stain positivity (% of lesional area) of P and DS segments of all specimens' sections: a smaller lesional area and a markedly higher positivity of both cellular markers in the distal side of the plaque is evident (*p

Supportive validation

Submitted by

Invitrogen Antibodies (provider)

Main image

Experimental details

Figure 3. Expression of ADAM-like decysin 1 (ADAMDEC1) and CD68 in nasal polyp tissues. (a) Representative images of immunofluorescence staining with anti-ADAMDEC1 (red), and anti-CD68 (green; macrophages) monoclonal antibodies, and DAPI (blue; nuclei). Scale bar =50 mm. (b) Correlation between CD68 and ADAMDEC1 positive cells. (c) Correlation between CD68 and ADAMDEC1 mRNA levels.