Antibody data
- Antibody Data
- Antigen structure
- References [79]
- Comments [0]
- Validations
- Immunohistochemistry [1]
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- Product number
- 66177-1-Ig - Provider product page

- Provider
- Proteintech Group
- Product name
- MPO antibody
- Antibody type
- Monoclonal
- Description
- KD/KO validated MPO antibody (Cat. #66177-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Rat
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgA
- Antibody clone number
- 4C11F6
- Vial size
- 20ul, 150ul
Submitted references Endothelial Hippo pathway regulates the neutrophil niche and lung fibrosis.
Oral Streptococcus salivarius Couples Neutrophil IRGM1 Signaling to NET Formation and Colorectal Cancer Metastasis.
Histidine alleviates Hashimoto's thyroiditis via the neutrophil extracellular traps-NF-κB signaling pathway.
Comprehensive single-cell metabolic profiling identifies targets to sensitize triple-negative breast cancer to chemo-immunotherapy.
Extracellular histone H3 induces METosis in acute liver failure by regulating the NRF2/HO-1/NQO1 pathway-mediated oxidative stress.
Enalaprilat reverses neutrophil polarization imbalance via targeting taurine-STING axis for treatment of diabetic wounds.
Amelioration of acute liver failure by a cinnamic acid derivative through inhibition of the ROS-NETosis axis.
NETs drive myocardial fibrosis in hypertension via an NF-κB/ferroptosis axis.
S100A8/S100A9 through PAD4 activation of neutrophil extracellular traps promotes granulomatous lobular mastitis.
Cancer Cell-Derived Large Extracellular Vesicles Promote Venous Thromboembolism by Activating NETosis Through Delivering CYBA.
Myeloperoxidase inhibits prostate cancer progression, suppresses the PI3K/AKT signaling pathway and reshapes the immune microenvironment.
NLRX1 mediated impaired microglial phagocytosis of NETs in cerebral ischemia and reperfusion injury.
Neutrophil extravasation and NETosis in decompression illness lung injury: A P-selectin/PSGL-1/NOX2/PAD4 axis governed pathway validated by multi-model interrogation.
11-keto-β-boswellic acid and Z-guggulsterone suppress HMGB1/TLR4 pathway activity and modulate microglial polarization to remodel perineuronal nets after nerve injury.
Activated Immune and Complement C3 Are Potential Contributors in MASH via Stimulating Neutrophil Extracellular Traps.
Identification of biomarkers associated with pathological tumor staging and their utility in the diagnosis and prognosis of prostate cancer.
An exploration of the protective effects of Ginsenoside Rb1 against acute lung injury using network pharmacology, molecular docking, molecular dynamics simulations, and in vivo experiments.
Cannabidiol regulates L-carnitine and butyric acid metabolism by modulating the gut microbiota to ameliorate collagen-induced arthritis.
A high concentration of neutrophil extracellular traps is observed in humans and mice suffering from endometriosis.
Multifaceted Immunomodulatory Nanocomplexes Target Neutrophilic-ROS Inflammation in Acute Lung Injury.
S100A12 triggers NETosis to aggravate myocardial infarction injury via the Annexin A5-calcium axis.
Targeting SLC7 A11 Ameliorates Ulcerative Colitis by Promoting Efferocytosis Through the ERK1/2 Pathway.
Macrophage-derived exosome miR-146a-5p modulates PNKP/DDOST/JAGN1 complex to regulate NETs formation in atherosclerosis.
Mesenchymal stem cell-derived apoptotic extracellular vesicles loaded with Prussian blue nanoparticles attenuate severe acute pancreatitis via neutrophil extracellular traps resolution and acinar-ductal metaplasia promotion.
Human urine-derived stem cells alleviate psoriasis by suppressing JAK2/STAT3 pathway-mediated macrophage polarization.
Bioactive compounds in the modulation of oxidative stress in monocytes and macrophages.
Siegesbeckia orientalis ethanol extract impedes RAGE-CD11b interaction driven by HMGB1 to alleviate neutrophil-involved neuronal injury poststroke.
Neutrophil extracellular traps trigger alveolar epithelial cell necroptosis through the cGAS-STING pathway during acute lung injury in mice.
miR-328-3p targets TLR2 to ameliorate oxygen-glucose deprivation injury and neutrophil extracellular trap formation in HUVECs via inhibition of the NF-κB signaling pathway.
Protective effect of Shenqi Wenfei Formula against lipopolysaccharide/cigarette smoke-induced COPD in Rat based on gut microbiota and network pharmacology analysis.
Staphylococcus aureus wraps around Candida albicans and synergistically escapes from Neutrophil extracellular traps.
Lipopolysaccharide in Bile Promotes the Neutrophil Extracellular Traps-Induced Gallstone Formation by Activating the Gallbladder Immune Barrier.
Neutrophil trapping and nexocytosis, mast cell-mediated processes for inflammatory signal relay.
ALDH3A1 upregulation inhibits neutrophils N2 polarization and halts oral cancer growth.
Mesenchymal stromal cells alleviate APAP-induced liver injury via extracellular vesicle-mediated regulation of the miR-186-5p/CXCL1 axis.
Neutrophil extracellular traps facilitate liver inflammation/fibrosis progression by entering macrophages and triggering AIM2 inflammasome-dependent pyroptosis.
Porphyromonas gingivalis promotes the progression of oral squamous cell carcinoma by stimulating the release of neutrophil extracellular traps in the tumor immune microenvironment.
Bakuchiol regulates TLR4/MyD88/NF-κB and Keap1/Nrf2/HO-1 pathways to protect against LPS-induced acute lung injury in vitro and in vivo.
Picroside II promotes HSC apoptosis and inhibits the cholestatic liver fibrosis in Mdr2(-/-) mice by polarizing M1 macrophages and balancing immune responses.
Overcoming therapeutic resistance in oncolytic herpes virotherapy by targeting IGF2BP3-induced NETosis in malignant glioma.
Sappanone A enhances hepatocyte proliferation in lipopolysaccharide-induced acute liver injury in mice by promoting injured hepatocyte apoptosis and regulating macrophage polarization.
Neutrophil extracellular traps in rheumatoid arthritis: Activating fibroblast-like synoviocytes via ATP citrate lyase.
Tracing Immunological Interaction in Trimethylamine N-Oxide Hydrogel-Derived Zwitterionic Microenvironment During Promoted Diabetic Wound Regeneration.
A combined model of serum neutrophil extracellular traps, CD8(+) T cells, and tumor proportion score provides better prediction of PD-1 inhibitor efficacy in patients with NSCLC.
Shirebi granules ameliorate acute gouty arthritis by inhibiting NETs-induced imbalance between immunity and inflammation.
Ultrasound-responsive theranostic platform for the timely monitoring and efficient thrombolysis in thrombi of tPA resistance.
Lung megakaryocytes engulf inhaled airborne particles to promote intrapulmonary inflammation and extrapulmonary distribution.
Inhibition of aquaporin-9 ameliorates severe acute pancreatitis and associated lung injury by NLRP3 and Nrf2/HO-1 pathways.
Bulk and single-cell RNA sequencing analysis with 101 machine learning combinations reveal neutrophil extracellular trap involvement in hepatic ischemia-reperfusion injury and early allograft dysfunction.
Neutrophil Extracellular Traps Aggravate Contrast-Induced Acute Kidney Injury by Damaging Glomeruli and Peritubular Capillaries.
Fusobacterium nucleatum-triggered neutrophil extracellular traps facilitate colorectal carcinoma progression.
Fasting-mimicking diet alleviates inflammatory pain by inhibiting neutrophil extracellular traps formation and neuroinflammation in the spinal cord.
Sperm induce macrophage extracellular trap formation via phagocytosis-dependent mechanism.
Low-dose ethanol consumption inhibits neutrophil extracellular traps formation to alleviate rheumatoid arthritis.
Recombinant GM-CSF enhances the bactericidal ability of PMNs by increasing intracellular IL-1β and improves the prognosis of secondary Pseudomonas aeruginosa pneumonia in sepsis.
Hesperetin attenuates sepsis-induced intestinal barrier injury by regulating neutrophil extracellular trap formation via the ROS/autophagy signaling pathway.
IGFBP2 derived from PO-MSCs promote epithelial barrier destruction by activating FAK signaling in nasal polyps.
Inhibition of neutrophil elastase prevents cigarette smoke exposure-induced formation of neutrophil extracellular traps and improves lung function in a mouse model of chronic obstructive pulmonary disease.
Elevated neutrophil extracellular traps by HBV-mediated S100A9-TLR4/RAGE-ROS cascade facilitate the growth and metastasis of hepatocellular carcinoma.
Neutrophil Extracellular Traps Release following Hypoxic-Ischemic Brain Injury in Newborn Rats Treated with Therapeutic Hypothermia.
Inhibition of CCR1 attenuates neuroinflammation via the JAK2/STAT3 signaling pathway after subarachnoid hemorrhage.
ETV4 Mediated Tumor-Associated Neutrophil Infiltration Facilitates Lymphangiogenesis and Lymphatic Metastasis of Bladder Cancer.
Knockdown of CD146 promotes endothelial-to-mesenchymal transition via Wnt/β-catenin pathway.
An integrated bioinformatic investigation of mitochondrial energy metabolism genes in colon adenocarcinoma followed by preliminary validation of CPT2 in tumor immune infiltration.
Leukocytes in Cerebral Thrombus Respond to Large-Vessel Occlusion in a Time-Dependent Manner and the Association of NETs With Collateral Flow.
Caspase-8 activation in neutrophils facilitates autoimmune kidney vasculitis through regulating CD4(+) effector memory T cells.
Si-Wu-Tang ameliorates bile duct ligation-induced liver fibrosis via modulating immune environment.
Increased co-expression of MEST and BRCA1 is associated with worse prognosis and immune infiltration in ovarian cancer.
Targeted inhibition of FcRn reduces NET formation to ameliorate experimental ulcerative colitis by accelerating ANCA clearance.
Effect of BLV Infection on the Immune Function of Polymorphonuclear Neutrophil in Dairy Cows.
The Role of Formyl Peptide Receptor 1 in Uterine Contraction During Parturition.
Stromal Neutrophil Extracellular Trap Density Is an Independent Prognostic Factor for Cervical Cancer Recurrence.
Effect of Copper, Zinc, and Selenium on the Formation of Bovine Neutrophil Extracellular Traps.
Neutrophil extracellular traps impair intestinal barrier functions in sepsis by regulating TLR9-mediated endoplasmic reticulum stress pathway.
Prion protein signaling induces M2 macrophage polarization and protects from lethal influenza infection in mice.
Interleukin 22 attenuated angiotensin II induced acute lung injury through inhibiting the apoptosis of pulmonary microvascular endothelial cells.
VE-cadherin involved in the pulmonary microvascular endothelial cell barrier injury induced by angiotensin II through modulating the cellular apoptosis and skeletal rearrangement.
Dephosphorylation of Y685-VE-Cadherin Involved in Pulmonary Microvascular Endothelial Barrier Injury Induced by Angiotensin II.
Persisting and Increasing Neutrophil Infiltration Associates with Gastric Carcinogenesis and E-cadherin Downregulation.
Wu C, Chen X, Zhou J, Wang H, Huang X, Tang X, Cao Z, Ding BS
Pharmacological research 2026 May;227:108169
Pharmacological research 2026 May;227:108169
Oral Streptococcus salivarius Couples Neutrophil IRGM1 Signaling to NET Formation and Colorectal Cancer Metastasis.
Liu F, Wang Y, Cai H, Yue Q, Liu X, Bao X, Wang Z, Li X, Wei L, Zhang Z, Xing F, Xu Y, Li X, Xu W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 May;13(25):e16546
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 May;13(25):e16546
Histidine alleviates Hashimoto's thyroiditis via the neutrophil extracellular traps-NF-κB signaling pathway.
Ding T, Wang Y, Zhang L, Zhou X, Cheng T, Wang Q, Yu L, Zhuang L, Jin G
Scientific reports 2026 Mar 26;16(1)
Scientific reports 2026 Mar 26;16(1)
Comprehensive single-cell metabolic profiling identifies targets to sensitize triple-negative breast cancer to chemo-immunotherapy.
Xu Y, Liu XY, Zhang H, Chen L, Wang H, Shao ZM, Xiao Y, Jiang YZ
Cell reports. Medicine 2026 Mar 17;7(3):102659
Cell reports. Medicine 2026 Mar 17;7(3):102659
Extracellular histone H3 induces METosis in acute liver failure by regulating the NRF2/HO-1/NQO1 pathway-mediated oxidative stress.
Zhang X, Guo J, Zhang D, Wang Y, Shi C, Gong Z
Biochimica et biophysica acta. Molecular basis of disease 2026 Jun;1872(5):168215
Biochimica et biophysica acta. Molecular basis of disease 2026 Jun;1872(5):168215
Enalaprilat reverses neutrophil polarization imbalance via targeting taurine-STING axis for treatment of diabetic wounds.
Lu L, Xiong Y, Liao J, Zhou J, Wang G, Qin Y, Zhang S, Zhao Y, Zhong X, Wang M, Zha K, Al-Smadi F, Liu G, Zhao Y, Mi B
Cell reports. Medicine 2026 Apr 21;7(4):102714
Cell reports. Medicine 2026 Apr 21;7(4):102714
Amelioration of acute liver failure by a cinnamic acid derivative through inhibition of the ROS-NETosis axis.
Yin J, Ding L, Zhao Z, Chen X, Huang J, Xiao Y, Gu L, Zhang X, Tong Q, Zhang Y
Molecular biomedicine 2026 Apr 13;7(1)
Molecular biomedicine 2026 Apr 13;7(1)
NETs drive myocardial fibrosis in hypertension via an NF-κB/ferroptosis axis.
Tu Q, Gong X, Yuan X, Tang Y, Huang R, Jiang Q, Li W
Frontiers in immunology 2025;16:1712786
Frontiers in immunology 2025;16:1712786
S100A8/S100A9 through PAD4 activation of neutrophil extracellular traps promotes granulomatous lobular mastitis.
Zhu T, Yu H, Wang W, Sun Y, Wang S, Ma D, Yao Y
Frontiers in immunology 2025;16:1672538
Frontiers in immunology 2025;16:1672538
Cancer Cell-Derived Large Extracellular Vesicles Promote Venous Thromboembolism by Activating NETosis Through Delivering CYBA.
Li X, Ju Y, Xu C, Ma S, Sun L, Guo Q, Liu M, Xie Y, Min L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(37):e07867
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(37):e07867
Myeloperoxidase inhibits prostate cancer progression, suppresses the PI3K/AKT signaling pathway and reshapes the immune microenvironment.
Zhou M, Liu N, Xie J, Zeng F, Zou S, Ju Y, Xiong X
Translational andrology and urology 2025 Oct 31;14(10):2885-2901
Translational andrology and urology 2025 Oct 31;14(10):2885-2901
NLRX1 mediated impaired microglial phagocytosis of NETs in cerebral ischemia and reperfusion injury.
Peng J, Huang Y, He T, Zhan Y, Liu J
Cell death and differentiation 2025 Nov;32(11):2160-2174
Cell death and differentiation 2025 Nov;32(11):2160-2174
Neutrophil extravasation and NETosis in decompression illness lung injury: A P-selectin/PSGL-1/NOX2/PAD4 axis governed pathway validated by multi-model interrogation.
Li Z, Wang S, Bai Y, Liu S, Huang J, You Y, Li J, Yu X, Han Y, Bao X
Free radical biology & medicine 2025 Nov;239:14-26
Free radical biology & medicine 2025 Nov;239:14-26
11-keto-β-boswellic acid and Z-guggulsterone suppress HMGB1/TLR4 pathway activity and modulate microglial polarization to remodel perineuronal nets after nerve injury.
Liao Y, Yang L, Ding Y, Guo C, Hu J, Xu X, Zhu H, Yang J, Zhao M
Journal of advanced research 2025 Nov 2;
Journal of advanced research 2025 Nov 2;
Activated Immune and Complement C3 Are Potential Contributors in MASH via Stimulating Neutrophil Extracellular Traps.
Liu A, Deng X, Hou S, Xi Y, Xu K
Cells 2025 May 19;14(10)
Cells 2025 May 19;14(10)
Identification of biomarkers associated with pathological tumor staging and their utility in the diagnosis and prognosis of prostate cancer.
Xu S, Shi H, Liu Y, Lin J, Wu X, Lu R, Fan Y, Tan W
Laboratory medicine 2025 Mar 10;56(2):118-128
Laboratory medicine 2025 Mar 10;56(2):118-128
An exploration of the protective effects of Ginsenoside Rb1 against acute lung injury using network pharmacology, molecular docking, molecular dynamics simulations, and in vivo experiments.
Zhang L, Xu SY, Shi MY, Wang H, Ding J, Tong JB, Zhu J, Li ZG, Yang QJ
International immunopharmacology 2025 Jun 17;158:114822
International immunopharmacology 2025 Jun 17;158:114822
Cannabidiol regulates L-carnitine and butyric acid metabolism by modulating the gut microbiota to ameliorate collagen-induced arthritis.
Geng Q, Wang Z, Shi T, Wen C, Xu J, Jiao Y, Diao W, Gu J, Wang Z, Zhao L, Deng T, Xiao C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156270
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156270
A high concentration of neutrophil extracellular traps is observed in humans and mice suffering from endometriosis.
Sun Y, Cai J, Zhang Y, Bao S
Journal of reproductive immunology 2025 Feb;167:104414
Journal of reproductive immunology 2025 Feb;167:104414
Multifaceted Immunomodulatory Nanocomplexes Target Neutrophilic-ROS Inflammation in Acute Lung Injury.
Su F, Zhang C, Zhang Q, Shen Y, Li S, Shi J, Zhu YX, Lin H, He B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(8):e2411823
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(8):e2411823
S100A12 triggers NETosis to aggravate myocardial infarction injury via the Annexin A5-calcium axis.
Zhang X, Song H, Liu D, Cai Y, Liu Z, Zhang X, Zhao X, Zhang Y, Jing Q, Yan C, Han Y
Nature communications 2025 Feb 18;16(1):1746
Nature communications 2025 Feb 18;16(1):1746
Targeting SLC7 A11 Ameliorates Ulcerative Colitis by Promoting Efferocytosis Through the ERK1/2 Pathway.
You M, Li J, Wang X, Liu Y, Chen S, Wang P
Inflammation 2025 Dec;48(6):4080-4093
Inflammation 2025 Dec;48(6):4080-4093
Macrophage-derived exosome miR-146a-5p modulates PNKP/DDOST/JAGN1 complex to regulate NETs formation in atherosclerosis.
Liu Z, Zhang W, Li Y, Fu Y, Zhang Y
Cellular signalling 2025 Dec;136:112176
Cellular signalling 2025 Dec;136:112176
Mesenchymal stem cell-derived apoptotic extracellular vesicles loaded with Prussian blue nanoparticles attenuate severe acute pancreatitis via neutrophil extracellular traps resolution and acinar-ductal metaplasia promotion.
Xu W, Cai W, Wu J, Hou X, Qi X, Wei Z, Cheng Y, Zheng Y, Cui B, He J
Journal of nanobiotechnology 2025 Dec 25;23(1):804
Journal of nanobiotechnology 2025 Dec 25;23(1):804
Human urine-derived stem cells alleviate psoriasis by suppressing JAK2/STAT3 pathway-mediated macrophage polarization.
Zhuo YQ, Huang QM, Gu HC, Wang LF, Tula D, Wei XY, Zhang ZH, Deng KY, Xin HB
Stem cell research & therapy 2025 Dec 17;17(1):38
Stem cell research & therapy 2025 Dec 17;17(1):38
Bioactive compounds in the modulation of oxidative stress in monocytes and macrophages.
Kushwaha R, Alugoju P, Anthikapalli NVA, Sharma R, Sedlářová M, Pospíšil P, Tamasi G, Bonechi C, Rossi C, Prasad A
Scientific reports 2025 Aug 31;15(1):32012
Scientific reports 2025 Aug 31;15(1):32012
Siegesbeckia orientalis ethanol extract impedes RAGE-CD11b interaction driven by HMGB1 to alleviate neutrophil-involved neuronal injury poststroke.
Chen J, Quan X, Li Y, Chen J, Hu J, Zhou M, Chen Y, Chen J, Wu C, Yu H, Zhao Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156541
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Apr;139:156541
Neutrophil extracellular traps trigger alveolar epithelial cell necroptosis through the cGAS-STING pathway during acute lung injury in mice.
Sha HX, Liu YB, Qiu YL, Zhong WJ, Yang NS, Zhang CY, Duan JX, Xiong JB, Guan CX, Zhou Y
International journal of biological sciences 2024;20(12):4713-4730
International journal of biological sciences 2024;20(12):4713-4730
miR-328-3p targets TLR2 to ameliorate oxygen-glucose deprivation injury and neutrophil extracellular trap formation in HUVECs via inhibition of the NF-κB signaling pathway.
Yao M, Fang C, Wang Z, Guo T, Wu D, Ma J, Wu J, Mo J
PloS one 2024;19(2):e0299382
PloS one 2024;19(2):e0299382
Protective effect of Shenqi Wenfei Formula against lipopolysaccharide/cigarette smoke-induced COPD in Rat based on gut microbiota and network pharmacology analysis.
Shi M, Xue Q, Xie J, Yang Q, Tong J, Zhu J, Gao Y, Ma X, Wu D, Li Z
Frontiers in microbiology 2024;15:1441015
Frontiers in microbiology 2024;15:1441015
Staphylococcus aureus wraps around Candida albicans and synergistically escapes from Neutrophil extracellular traps.
Jing Q, Liu R, Jiang Q, Liu Y, He J, Zhou X, Yu OY, Chu CH, Cheng L, Ren B, Li M
Frontiers in immunology 2024;15:1422440
Frontiers in immunology 2024;15:1422440
Lipopolysaccharide in Bile Promotes the Neutrophil Extracellular Traps-Induced Gallstone Formation by Activating the Gallbladder Immune Barrier.
Yu J, Meng Z, Liu X, Zheng Y, Xue D, Hao C, Wang L
ImmunoTargets and therapy 2024;13:789-803
ImmunoTargets and therapy 2024;13:789-803
Neutrophil trapping and nexocytosis, mast cell-mediated processes for inflammatory signal relay.
Mihlan M, Wissmann S, Gavrilov A, Kaltenbach L, Britz M, Franke K, Hummel B, Imle A, Suzuki R, Stecher M, Glaser KM, Lorentz A, Carmeliet P, Yokomizo T, Hilgendorf I, Sawarkar R, Diz-Muñoz A, Buescher JM, Mittler G, Maurer M, Krause K, Babina M, Erpenbeck L, Frank M, Rambold AS, Lämmermann T
Cell 2024 Sep 19;187(19):5316-5335.e28
Cell 2024 Sep 19;187(19):5316-5335.e28
ALDH3A1 upregulation inhibits neutrophils N2 polarization and halts oral cancer growth.
He Y, Qu Y, Jin S, Zhang Y, Qin L
Oral diseases 2024 Oct;30(7):4231-4242
Oral diseases 2024 Oct;30(7):4231-4242
Mesenchymal stromal cells alleviate APAP-induced liver injury via extracellular vesicle-mediated regulation of the miR-186-5p/CXCL1 axis.
Zhao E, Liang R, Li P, Lu D, Chen S, Tan W, Qin Y, Zhang Y, Zhang Y, Zhang Q, Liu Q
Stem cell research & therapy 2024 Nov 3;15(1):392
Stem cell research & therapy 2024 Nov 3;15(1):392
Neutrophil extracellular traps facilitate liver inflammation/fibrosis progression by entering macrophages and triggering AIM2 inflammasome-dependent pyroptosis.
Zhang Y, Wu R, Zhan X, Wang XY, Xiang LW, Duan YQ, You Y, Zhang JB, Wu R, Zhang YY, Duan L
Cell communication and signaling : CCS 2024 Nov 20;22(1):556
Cell communication and signaling : CCS 2024 Nov 20;22(1):556
Porphyromonas gingivalis promotes the progression of oral squamous cell carcinoma by stimulating the release of neutrophil extracellular traps in the tumor immune microenvironment.
Guo ZC, Jing SL, Jia XY, Elayah SA, Xie LY, Cui H, Tu JB, Na SJ
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 May;73(5):693-705
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 May;73(5):693-705
Bakuchiol regulates TLR4/MyD88/NF-κB and Keap1/Nrf2/HO-1 pathways to protect against LPS-induced acute lung injury in vitro and in vivo.
Zhao L, Zhang Z, Li P, Gao Y, Shi Y
Naunyn-Schmiedeberg's archives of pharmacology 2024 May;397(5):3301-3312
Naunyn-Schmiedeberg's archives of pharmacology 2024 May;397(5):3301-3312
Picroside II promotes HSC apoptosis and inhibits the cholestatic liver fibrosis in Mdr2(-/-) mice by polarizing M1 macrophages and balancing immune responses.
Jia K, Ma Z, Zhang Y, Xie K, Li J, Wu J, Qu J, Li F, Li X
Chinese journal of natural medicines 2024 Jul;22(7):582-598
Chinese journal of natural medicines 2024 Jul;22(7):582-598
Overcoming therapeutic resistance in oncolytic herpes virotherapy by targeting IGF2BP3-induced NETosis in malignant glioma.
Dai W, Tian R, Yu L, Bian S, Chen Y, Yin B, Luan Y, Chen S, Fan Z, Yan R, Pan X, Hou Y, Li R, Chen J, Shu M
Nature communications 2024 Jan 2;15(1):131
Nature communications 2024 Jan 2;15(1):131
Sappanone A enhances hepatocyte proliferation in lipopolysaccharide-induced acute liver injury in mice by promoting injured hepatocyte apoptosis and regulating macrophage polarization.
He J, Li L, Yan X, Li Y, Wang Y, Huang J, Li C, Liu W, Qi J
International immunopharmacology 2024 Dec 5;142(Pt A):113055
International immunopharmacology 2024 Dec 5;142(Pt A):113055
Neutrophil extracellular traps in rheumatoid arthritis: Activating fibroblast-like synoviocytes via ATP citrate lyase.
Li J, Wang X, Tan M, Zheng J, Mao J, Hao J, Shen H
International immunopharmacology 2024 Dec 25;143(Pt 3):113518
International immunopharmacology 2024 Dec 25;143(Pt 3):113518
Tracing Immunological Interaction in Trimethylamine N-Oxide Hydrogel-Derived Zwitterionic Microenvironment During Promoted Diabetic Wound Regeneration.
Li Z, Li L, Yue M, Peng Q, Pu X, Zhou Y
Advanced materials (Deerfield Beach, Fla.) 2024 Aug;36(33):e2402738
Advanced materials (Deerfield Beach, Fla.) 2024 Aug;36(33):e2402738
A combined model of serum neutrophil extracellular traps, CD8(+) T cells, and tumor proportion score provides better prediction of PD-1 inhibitor efficacy in patients with NSCLC.
Guo J, Shu T, Zhang H, Huang N, Ren J, Lin L, Wu J, Wang Y, Huang Z, Bin J, Liao Y, Shi M, Liao W, Huang N
The FEBS journal 2024 Aug;291(15):3403-3416
The FEBS journal 2024 Aug;291(15):3403-3416
Shirebi granules ameliorate acute gouty arthritis by inhibiting NETs-induced imbalance between immunity and inflammation.
Li X, Mao X, Jiang H, Xia C, Fu L, Gao W, Chen W, Li W, Wang P, Zhang Y, Xu H
Chinese medicine 2024 Aug 9;19(1):105
Chinese medicine 2024 Aug 9;19(1):105
Ultrasound-responsive theranostic platform for the timely monitoring and efficient thrombolysis in thrombi of tPA resistance.
Lin L, Ba Z, Tian H, Qin H, Chen X, Zhou X, Zhao S, Li L, Xue F, Li H, He L, Li X, Du J, Zhou Z, Zeng W
Nature communications 2024 Aug 4;15(1):6610
Nature communications 2024 Aug 4;15(1):6610
Lung megakaryocytes engulf inhaled airborne particles to promote intrapulmonary inflammation and extrapulmonary distribution.
Qiu J, Ma J, Dong Z, Ren Q, Shan Q, Liu J, Gao M, Liu G, Zhang S, Qu G, Jiang G, Liu S
Nature communications 2024 Aug 27;15(1):7396
Nature communications 2024 Aug 27;15(1):7396
Inhibition of aquaporin-9 ameliorates severe acute pancreatitis and associated lung injury by NLRP3 and Nrf2/HO-1 pathways.
Chen J, Zhu X, Wang Z, Rützler M, Lu Q, Xu H, Andersson R, Dai Y, Shen Z, Calamita G, Xie S, Bai Y, Chen B
International immunopharmacology 2024 Aug 20;137:112450
International immunopharmacology 2024 Aug 20;137:112450
Bulk and single-cell RNA sequencing analysis with 101 machine learning combinations reveal neutrophil extracellular trap involvement in hepatic ischemia-reperfusion injury and early allograft dysfunction.
Xie M, He Z, Bin B, Wen N, Wu J, Cai X, Sun X
International immunopharmacology 2024 Apr 20;131:111874
International immunopharmacology 2024 Apr 20;131:111874
Neutrophil Extracellular Traps Aggravate Contrast-Induced Acute Kidney Injury by Damaging Glomeruli and Peritubular Capillaries.
Wang H, Gao T, Zhang R, Hu J, Gao S, Wang Y, Qi X, Zhou Y, Zheng G, Dong H
Journal of inflammation research 2023;16:5629-5646
Journal of inflammation research 2023;16:5629-5646
Fusobacterium nucleatum-triggered neutrophil extracellular traps facilitate colorectal carcinoma progression.
Kong X, Zhang Y, Xiang L, You Y, Duan Y, Zhao Y, Li S, Wu R, Zhang J, Zhou L, Duan L
Journal of experimental & clinical cancer research : CR 2023 Sep 9;42(1):236
Journal of experimental & clinical cancer research : CR 2023 Sep 9;42(1):236
Fasting-mimicking diet alleviates inflammatory pain by inhibiting neutrophil extracellular traps formation and neuroinflammation in the spinal cord.
Li T, Yue Y, Ma Y, Zhong Z, Guo M, Zhang J, Wang Z, Miao C
Cell communication and signaling : CCS 2023 Sep 21;21(1):250
Cell communication and signaling : CCS 2023 Sep 21;21(1):250
Sperm induce macrophage extracellular trap formation via phagocytosis-dependent mechanism.
Lu C, Wu Z, Gao H, Li H, Deng R, Luo N, Fan S, Li X, He D, Zhao H
Biology of reproduction 2023 Sep 12;109(3):319-329
Biology of reproduction 2023 Sep 12;109(3):319-329
Low-dose ethanol consumption inhibits neutrophil extracellular traps formation to alleviate rheumatoid arthritis.
Jin L, Zhang Z, Pan P, Zhao Y, Zhou M, Liu L, Zhai Y, Wang H, Xu L, Mei D, Zhang H, Yang Y, Hua J, Zhang X, Zhang L
Communications biology 2023 Oct 26;6(1):1088
Communications biology 2023 Oct 26;6(1):1088
Recombinant GM-CSF enhances the bactericidal ability of PMNs by increasing intracellular IL-1β and improves the prognosis of secondary Pseudomonas aeruginosa pneumonia in sepsis.
Tu F, Pan L, Wu W, Cai Y, Li J, Wang X, Lai X, Chen Z, Ye L, Wang S
Journal of leukocyte biology 2023 Oct 26;114(5):443-458
Journal of leukocyte biology 2023 Oct 26;114(5):443-458
Hesperetin attenuates sepsis-induced intestinal barrier injury by regulating neutrophil extracellular trap formation via the ROS/autophagy signaling pathway.
Chen F, Chu C, Wang X, Yang C, Deng Y, Duan Z, Wang K, Liu B, Ji W, Ding W
Food & function 2023 May 11;14(9):4213-4227
Food & function 2023 May 11;14(9):4213-4227
IGFBP2 derived from PO-MSCs promote epithelial barrier destruction by activating FAK signaling in nasal polyps.
You B, Zhang T, Zhang W, Pei Y, Huang D, Lei Y, Zhang S, Qiu C, Zhang J, Gu Z, Cheng L, Chen J
iScience 2023 Mar 17;26(3):106151
iScience 2023 Mar 17;26(3):106151
Inhibition of neutrophil elastase prevents cigarette smoke exposure-induced formation of neutrophil extracellular traps and improves lung function in a mouse model of chronic obstructive pulmonary disease.
Wang K, Liao Y, Li X, Wang R, Zeng Z, Cheng M, Gao L, Xu D, Wen F, Wang T, Chen J
International immunopharmacology 2023 Jan;114:109537
International immunopharmacology 2023 Jan;114:109537
Elevated neutrophil extracellular traps by HBV-mediated S100A9-TLR4/RAGE-ROS cascade facilitate the growth and metastasis of hepatocellular carcinoma.
Zhan X, Wu R, Kong XH, You Y, He K, Sun XY, Huang Y, Chen WX, Duan L
Cancer communications (London, England) 2023 Feb;43(2):225-245
Cancer communications (London, England) 2023 Feb;43(2):225-245
Neutrophil Extracellular Traps Release following Hypoxic-Ischemic Brain Injury in Newborn Rats Treated with Therapeutic Hypothermia.
Bernis ME, Zweyer M, Maes E, Schleehuber Y, Sabir H
International journal of molecular sciences 2023 Feb 10;24(4)
International journal of molecular sciences 2023 Feb 10;24(4)
Inhibition of CCR1 attenuates neuroinflammation via the JAK2/STAT3 signaling pathway after subarachnoid hemorrhage.
Tian Q, Li Y, Feng S, Liu C, Guo Y, Wang G, Wei H, Chen Z, Gu L, Li M
International immunopharmacology 2023 Dec;125(Pt A):111106
International immunopharmacology 2023 Dec;125(Pt A):111106
ETV4 Mediated Tumor-Associated Neutrophil Infiltration Facilitates Lymphangiogenesis and Lymphatic Metastasis of Bladder Cancer.
Zhang Q, Liu S, Wang H, Xiao K, Lu J, Chen S, Huang M, Xie R, Lin T, Chen X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Apr;10(11):e2205613
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Apr;10(11):e2205613
Knockdown of CD146 promotes endothelial-to-mesenchymal transition via Wnt/β-catenin pathway.
Zhang ZY, Zhai C, Yang XY, Li HB, Wu LL, Li L
PloS one 2022;17(8):e0273542
PloS one 2022;17(8):e0273542
An integrated bioinformatic investigation of mitochondrial energy metabolism genes in colon adenocarcinoma followed by preliminary validation of CPT2 in tumor immune infiltration.
Cao Z, Lin J, Fu G, Niu L, Yang Z, Cai W
Frontiers in immunology 2022;13:959967
Frontiers in immunology 2022;13:959967
Leukocytes in Cerebral Thrombus Respond to Large-Vessel Occlusion in a Time-Dependent Manner and the Association of NETs With Collateral Flow.
Chen X, Wang L, Jiang M, Lin L, Ba Z, Tian H, Li G, Chen L, Liu Q, Hou X, Wu M, Liu L, Ju W, Zeng W, Zhou Z
Frontiers in immunology 2022;13:834562
Frontiers in immunology 2022;13:834562
Caspase-8 activation in neutrophils facilitates autoimmune kidney vasculitis through regulating CD4(+) effector memory T cells.
Hu J, Huang Z, Yu M, Zhang P, Xia Z, Gao C
Frontiers in immunology 2022;13:1038134
Frontiers in immunology 2022;13:1038134
Si-Wu-Tang ameliorates bile duct ligation-induced liver fibrosis via modulating immune environment.
Ma Z, Xue X, Bai J, Cai Y, Jin X, Jia K, Ding M, Lyu X, Li X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Nov;155:113834
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Nov;155:113834
Increased co-expression of MEST and BRCA1 is associated with worse prognosis and immune infiltration in ovarian cancer.
Zhang J, Yu S, Li Q, Wang Q, Zhang J
Gynecologic oncology 2022 Mar;164(3):566-576
Gynecologic oncology 2022 Mar;164(3):566-576
Targeted inhibition of FcRn reduces NET formation to ameliorate experimental ulcerative colitis by accelerating ANCA clearance.
Wen C, Hu H, Yang W, Zhao Y, Zheng L, Jiang X, Wang L
International immunopharmacology 2022 Dec;113(Pt B):109474
International immunopharmacology 2022 Dec;113(Pt B):109474
Effect of BLV Infection on the Immune Function of Polymorphonuclear Neutrophil in Dairy Cows.
Lv G, Wang H, Wang J, Lian S, Wu R
Frontiers in veterinary science 2021;8:737608
Frontiers in veterinary science 2021;8:737608
The Role of Formyl Peptide Receptor 1 in Uterine Contraction During Parturition.
Chen C, Zhu S, Bai L, Sui M, Chen D
Frontiers in pharmacology 2021;12:696697
Frontiers in pharmacology 2021;12:696697
Stromal Neutrophil Extracellular Trap Density Is an Independent Prognostic Factor for Cervical Cancer Recurrence.
Yan B, Dai X, Ma Q, Wu X
Frontiers in oncology 2021;11:659445
Frontiers in oncology 2021;11:659445
Effect of Copper, Zinc, and Selenium on the Formation of Bovine Neutrophil Extracellular Traps.
Zhou X, Wang H, Lian S, Wang J, Wu R
Biological trace element research 2021 Sep;199(9):3312-3318
Biological trace element research 2021 Sep;199(9):3312-3318
Neutrophil extracellular traps impair intestinal barrier functions in sepsis by regulating TLR9-mediated endoplasmic reticulum stress pathway.
Sun S, Duan Z, Wang X, Chu C, Yang C, Chen F, Wang D, Wang C, Li Q, Ding W
Cell death & disease 2021 Jun 11;12(6):606
Cell death & disease 2021 Jun 11;12(6):606
Prion protein signaling induces M2 macrophage polarization and protects from lethal influenza infection in mice.
Chida J, Hara H, Uchiyama K, Takahashi E, Miyata H, Kosako H, Tomioka Y, Ito T, Horiuchi H, Matsuda H, Kido H, Sakaguchi S
PLoS pathogens 2020 Aug;16(8):e1008823
PLoS pathogens 2020 Aug;16(8):e1008823
Interleukin 22 attenuated angiotensin II induced acute lung injury through inhibiting the apoptosis of pulmonary microvascular endothelial cells.
Wu Z, Hu Z, Cai X, Ren W, Dai F, Liu H, Chang J, Li B
Scientific reports 2017 May 19;7(1):2210
Scientific reports 2017 May 19;7(1):2210
VE-cadherin involved in the pulmonary microvascular endothelial cell barrier injury induced by angiotensin II through modulating the cellular apoptosis and skeletal rearrangement.
Wu Z, Liu H, Ren W, Dai F, Chang J, Li B
American journal of translational research 2016;8(10):4310-4319
American journal of translational research 2016;8(10):4310-4319
Dephosphorylation of Y685-VE-Cadherin Involved in Pulmonary Microvascular Endothelial Barrier Injury Induced by Angiotensin II.
Wu Z, Wang Z, Dai F, Liu H, Ren W, Chang J, Li B
Mediators of inflammation 2016;2016:8696481
Mediators of inflammation 2016;2016:8696481
Persisting and Increasing Neutrophil Infiltration Associates with Gastric Carcinogenesis and E-cadherin Downregulation.
Fu H, Ma Y, Yang M, Zhang C, Huang H, Xia Y, Lu L, Jin W, Cui D
Scientific reports 2016 Jul 14;6:29762
Scientific reports 2016 Jul 14;6:29762
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- The MPO antibody from Proteintech is a mouse monoclonal antibody to a recombinant protein of human MPO. This antibody recognizes human antigen. The MPO antibody has been validated for the following applications: ELISA, IHC analysis.