66177-1-Ig

antibody from Proteintech Group

Targeting: MPO

Provider product page for 66177-1-Ig

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Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [35]
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Validations
Immunohistochemistry [1]

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Product number: 66177-1-Ig - Provider product page
Provider: Proteintech Group
Product name: MPO antibody
Antibody type: Monoclonal
Description: KD/KO validated MPO antibody (Cat. #66177-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
Reactivity: Human, Rat
Host: Mouse
Conjugate: Unconjugated
Isotype: IgA
Antibody clone number: 4C11F6
Vial size: 20ul, 150ul

MPO protein structure - 66177-1-Ig shown in red.

Submitted references miR-328-3p targets TLR2 to ameliorate oxygen-glucose deprivation injury and neutrophil extracellular trap formation in HUVECs via inhibition of the NF-κB signaling pathway.

Yao M, Fang C, Wang Z, Guo T, Wu D, Ma J, Wu J, Mo J
PloS one 2024;19(2):e0299382

ALDH3A1 upregulation inhibits neutrophils N2 polarization and halts oral cancer growth.

He Y, Qu Y, Jin S, Zhang Y, Qin L
Oral diseases 2024 Oct;30(7):4231-4242

Porphyromonas gingivalis promotes the progression of oral squamous cell carcinoma by stimulating the release of neutrophil extracellular traps in the tumor immune microenvironment.

Guo ZC, Jing SL, Jia XY, Elayah SA, Xie LY, Cui H, Tu JB, Na SJ
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2024 May;73(5):693-705

Bakuchiol regulates TLR4/MyD88/NF-κB and Keap1/Nrf2/HO-1 pathways to protect against LPS-induced acute lung injury in vitro and in vivo.

Zhao L, Zhang Z, Li P, Gao Y, Shi Y
Naunyn-Schmiedeberg's archives of pharmacology 2024 May;397(5):3301-3312

Bulk and single-cell RNA sequencing analysis with 101 machine learning combinations reveal neutrophil extracellular trap involvement in hepatic ischemia-reperfusion injury and early allograft dysfunction.

Xie M, He Z, Bin B, Wen N, Wu J, Cai X, Sun X
International immunopharmacology 2024 Apr 20;131:111874

Neutrophil Extracellular Traps Aggravate Contrast-Induced Acute Kidney Injury by Damaging Glomeruli and Peritubular Capillaries.

Wang H, Gao T, Zhang R, Hu J, Gao S, Wang Y, Qi X, Zhou Y, Zheng G, Dong H
Journal of inflammation research 2023;16:5629-5646

Fusobacterium nucleatum-triggered neutrophil extracellular traps facilitate colorectal carcinoma progression.

Kong X, Zhang Y, Xiang L, You Y, Duan Y, Zhao Y, Li S, Wu R, Zhang J, Zhou L, Duan L
Journal of experimental & clinical cancer research : CR 2023 Sep 9;42(1):236

Fasting-mimicking diet alleviates inflammatory pain by inhibiting neutrophil extracellular traps formation and neuroinflammation in the spinal cord.

Li T, Yue Y, Ma Y, Zhong Z, Guo M, Zhang J, Wang Z, Miao C
Cell communication and signaling : CCS 2023 Sep 21;21(1):250

Sperm induce macrophage extracellular trap formation via phagocytosis-dependent mechanism.

Lu C, Wu Z, Gao H, Li H, Deng R, Luo N, Fan S, Li X, He D, Zhao H
Biology of reproduction 2023 Sep 12;109(3):319-329

Low-dose ethanol consumption inhibits neutrophil extracellular traps formation to alleviate rheumatoid arthritis.

Jin L, Zhang Z, Pan P, Zhao Y, Zhou M, Liu L, Zhai Y, Wang H, Xu L, Mei D, Zhang H, Yang Y, Hua J, Zhang X, Zhang L
Communications biology 2023 Oct 26;6(1):1088

Recombinant GM-CSF enhances the bactericidal ability of PMNs by increasing intracellular IL-1β and improves the prognosis of secondary Pseudomonas aeruginosa pneumonia in sepsis.

Tu F, Pan L, Wu W, Cai Y, Li J, Wang X, Lai X, Chen Z, Ye L, Wang S
Journal of leukocyte biology 2023 Oct 26;114(5):443-458

Hesperetin attenuates sepsis-induced intestinal barrier injury by regulating neutrophil extracellular trap formation via the ROS/autophagy signaling pathway.

Chen F, Chu C, Wang X, Yang C, Deng Y, Duan Z, Wang K, Liu B, Ji W, Ding W
Food & function 2023 May 11;14(9):4213-4227

IGFBP2 derived from PO-MSCs promote epithelial barrier destruction by activating FAK signaling in nasal polyps.

You B, Zhang T, Zhang W, Pei Y, Huang D, Lei Y, Zhang S, Qiu C, Zhang J, Gu Z, Cheng L, Chen J
iScience 2023 Mar 17;26(3):106151

Inhibition of neutrophil elastase prevents cigarette smoke exposure-induced formation of neutrophil extracellular traps and improves lung function in a mouse model of chronic obstructive pulmonary disease.

Wang K, Liao Y, Li X, Wang R, Zeng Z, Cheng M, Gao L, Xu D, Wen F, Wang T, Chen J
International immunopharmacology 2023 Jan;114:109537

Elevated neutrophil extracellular traps by HBV-mediated S100A9-TLR4/RAGE-ROS cascade facilitate the growth and metastasis of hepatocellular carcinoma.

Zhan X, Wu R, Kong XH, You Y, He K, Sun XY, Huang Y, Chen WX, Duan L
Cancer communications (London, England) 2023 Feb;43(2):225-245

Neutrophil Extracellular Traps Release following Hypoxic-Ischemic Brain Injury in Newborn Rats Treated with Therapeutic Hypothermia.

Bernis ME, Zweyer M, Maes E, Schleehuber Y, Sabir H
International journal of molecular sciences 2023 Feb 10;24(4)

Inhibition of CCR1 attenuates neuroinflammation via the JAK2/STAT3 signaling pathway after subarachnoid hemorrhage.

Tian Q, Li Y, Feng S, Liu C, Guo Y, Wang G, Wei H, Chen Z, Gu L, Li M
International immunopharmacology 2023 Dec;125(Pt A):111106

ETV4 Mediated Tumor-Associated Neutrophil Infiltration Facilitates Lymphangiogenesis and Lymphatic Metastasis of Bladder Cancer.

Zhang Q, Liu S, Wang H, Xiao K, Lu J, Chen S, Huang M, Xie R, Lin T, Chen X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Apr;10(11):e2205613

Knockdown of CD146 promotes endothelial-to-mesenchymal transition via Wnt/β-catenin pathway.

Zhang ZY, Zhai C, Yang XY, Li HB, Wu LL, Li L
PloS one 2022;17(8):e0273542

An integrated bioinformatic investigation of mitochondrial energy metabolism genes in colon adenocarcinoma followed by preliminary validation of CPT2 in tumor immune infiltration.

Cao Z, Lin J, Fu G, Niu L, Yang Z, Cai W
Frontiers in immunology 2022;13:959967

Leukocytes in Cerebral Thrombus Respond to Large-Vessel Occlusion in a Time-Dependent Manner and the Association of NETs With Collateral Flow.

Chen X, Wang L, Jiang M, Lin L, Ba Z, Tian H, Li G, Chen L, Liu Q, Hou X, Wu M, Liu L, Ju W, Zeng W, Zhou Z
Frontiers in immunology 2022;13:834562

Caspase-8 activation in neutrophils facilitates autoimmune kidney vasculitis through regulating CD4(+) effector memory T cells.

Hu J, Huang Z, Yu M, Zhang P, Xia Z, Gao C
Frontiers in immunology 2022;13:1038134

Si-Wu-Tang ameliorates bile duct ligation-induced liver fibrosis via modulating immune environment.

Ma Z, Xue X, Bai J, Cai Y, Jin X, Jia K, Ding M, Lyu X, Li X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Nov;155:113834

Increased co-expression of MEST and BRCA1 is associated with worse prognosis and immune infiltration in ovarian cancer.

Zhang J, Yu S, Li Q, Wang Q, Zhang J
Gynecologic oncology 2022 Mar;164(3):566-576

Targeted inhibition of FcRn reduces NET formation to ameliorate experimental ulcerative colitis by accelerating ANCA clearance.

Wen C, Hu H, Yang W, Zhao Y, Zheng L, Jiang X, Wang L
International immunopharmacology 2022 Dec;113(Pt B):109474

Effect of BLV Infection on the Immune Function of Polymorphonuclear Neutrophil in Dairy Cows.

Lv G, Wang H, Wang J, Lian S, Wu R
Frontiers in veterinary science 2021;8:737608

The Role of Formyl Peptide Receptor 1 in Uterine Contraction During Parturition.

Chen C, Zhu S, Bai L, Sui M, Chen D
Frontiers in pharmacology 2021;12:696697

Stromal Neutrophil Extracellular Trap Density Is an Independent Prognostic Factor for Cervical Cancer Recurrence.

Yan B, Dai X, Ma Q, Wu X
Frontiers in oncology 2021;11:659445

Effect of Copper, Zinc, and Selenium on the Formation of Bovine Neutrophil Extracellular Traps.

Zhou X, Wang H, Lian S, Wang J, Wu R
Biological trace element research 2021 Sep;199(9):3312-3318

Neutrophil extracellular traps impair intestinal barrier functions in sepsis by regulating TLR9-mediated endoplasmic reticulum stress pathway.

Sun S, Duan Z, Wang X, Chu C, Yang C, Chen F, Wang D, Wang C, Li Q, Ding W
Cell death & disease 2021 Jun 11;12(6):606

Prion protein signaling induces M2 macrophage polarization and protects from lethal influenza infection in mice.

Chida J, Hara H, Uchiyama K, Takahashi E, Miyata H, Kosako H, Tomioka Y, Ito T, Horiuchi H, Matsuda H, Kido H, Sakaguchi S
PLoS pathogens 2020 Aug;16(8):e1008823

Interleukin 22 attenuated angiotensin II induced acute lung injury through inhibiting the apoptosis of pulmonary microvascular endothelial cells.

Wu Z, Hu Z, Cai X, Ren W, Dai F, Liu H, Chang J, Li B
Scientific reports 2017 May 19;7(1):2210

VE-cadherin involved in the pulmonary microvascular endothelial cell barrier injury induced by angiotensin II through modulating the cellular apoptosis and skeletal rearrangement.

Wu Z, Liu H, Ren W, Dai F, Chang J, Li B
American journal of translational research 2016;8(10):4310-4319

Dephosphorylation of Y685-VE-Cadherin Involved in Pulmonary Microvascular Endothelial Barrier Injury Induced by Angiotensin II.

Wu Z, Wang Z, Dai F, Liu H, Ren W, Chang J, Li B
Mediators of inflammation 2016;2016:8696481

Persisting and Increasing Neutrophil Infiltration Associates with Gastric Carcinogenesis and E-cadherin Downregulation.

Fu H, Ma Y, Yang M, Zhang C, Huang H, Xia Y, Lu L, Jin W, Cui D
Scientific reports 2016 Jul 14;6:29762

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The MPO antibody from Proteintech is a mouse monoclonal antibody to a recombinant protein of human MPO. This antibody recognizes human antigen. The MPO antibody has been validated for the following applications: ELISA, IHC analysis.
Appendix: 66177-1-Ig.pdf

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