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- References [15]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 18066-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#18066-1-AP, RRID:AB_10643992
- Product name
- USP49 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated USP49 antibody (Cat. #18066-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Genome-wide screening for deubiquitinase subfamily identifies ubiquitin-specific protease 49 as a novel regulator of odontogenesis.
USP49-Mediated Histone H2B Deubiquitination Regulates HCT116 Cell Proliferation through MDM2-p53 Axis.
Fbxo45 facilitates pancreatic carcinoma progression by targeting USP49 for ubiquitination and degradation.
c-MYC-USP49-BAG2 axis promotes proliferation and chemoresistance of colorectal cancer cells in vitro.
USP49 is a novel deubiquitylating enzyme for γ H2AX in DNA double-strand break repair.
USP32 confers cancer cell resistance to YM155 via promoting ER-associated degradation of solute carrier protein SLC35F2.
CCAT1/FABP5 promotes tumour progression through mediating fatty acid metabolism and stabilizing PI3K/AKT/mTOR signalling in lung adenocarcinoma.
miR-5000-3p confers oxaliplatin resistance by targeting ubiquitin-specific peptidase 49 in colorectal cancer.
Ubiquitin-specific protease 49 attenuates IL-1β-induced rat primary chondrocyte apoptosis by facilitating Axin deubiquitination and subsequent Wnt/β-catenin signaling cascade inhibition.
Differential Expression of DUB Genes in Ovarian Cells Treated with Di-2-Ethylhexyl Phthalate.
USP49 inhibits ischemia-reperfusion-induced cell viability suppression and apoptosis in human AC16 cardiomyocytes through DUSP1-JNK1/2 signaling.
Ubiquitin specific peptidase 49 inhibits non-small cell lung cancer cell growth by suppressing PI3K/AKT signaling.
USP49 potently stabilizes APOBEC3G protein by removing ubiquitin and inhibits HIV-1 replication.
USP49 negatively regulates cellular antiviral responses via deconjugating K63-linked ubiquitination of MITA.
USP49 negatively regulates tumorigenesis and chemoresistance through FKBP51-AKT signaling.
Kaushal K, Kim EJ, Tyagi A, Karapurkar JK, Haq S, Jung HS, Kim KS, Ramakrishna S
Cell death and differentiation 2022 Sep;29(9):1689-1704
Cell death and differentiation 2022 Sep;29(9):1689-1704
USP49-Mediated Histone H2B Deubiquitination Regulates HCT116 Cell Proliferation through MDM2-p53 Axis.
Shi L, Shen X, Shen Y
Molecular and cellular biology 2022 Mar 17;42(3):e0043421
Molecular and cellular biology 2022 Mar 17;42(3):e0043421
Fbxo45 facilitates pancreatic carcinoma progression by targeting USP49 for ubiquitination and degradation.
Wu L, Yu K, Chen K, Zhu X, Yang Z, Wang Q, Gao J, Wang Y, Cao T, Xu H, Pan X, Wang L, Xia J, Li Y, Wang ZP, Ma J
Cell death & disease 2022 Mar 12;13(3):231
Cell death & disease 2022 Mar 12;13(3):231
c-MYC-USP49-BAG2 axis promotes proliferation and chemoresistance of colorectal cancer cells in vitro.
Tu R, Kang W, Kang Y, Chen Z, Zhang P, Xiong X, Ma J, Du RL, Zhang C
Biochemical and biophysical research communications 2022 Jun 4;607:117-123
Biochemical and biophysical research communications 2022 Jun 4;607:117-123
USP49 is a novel deubiquitylating enzyme for γ H2AX in DNA double-strand break repair.
Matsui M, Kajita S, Tsuchiya Y, Torii W, Tamekuni S, Nishi R
Gene 2022 Jul 30;833:146599
Gene 2022 Jul 30;833:146599
USP32 confers cancer cell resistance to YM155 via promoting ER-associated degradation of solute carrier protein SLC35F2.
Chandrasekaran AP, Kaushal K, Park CH, Kim KS, Ramakrishna S
Theranostics 2021;11(20):9752-9771
Theranostics 2021;11(20):9752-9771
CCAT1/FABP5 promotes tumour progression through mediating fatty acid metabolism and stabilizing PI3K/AKT/mTOR signalling in lung adenocarcinoma.
Chen J, Alduais Y, Zhang K, Zhu X, Chen B
Journal of cellular and molecular medicine 2021 Oct;25(19):9199-9213
Journal of cellular and molecular medicine 2021 Oct;25(19):9199-9213
miR-5000-3p confers oxaliplatin resistance by targeting ubiquitin-specific peptidase 49 in colorectal cancer.
Zhuang YY, Zhong W, Xia ZS, Lin SZ, Chan MC, Jiang K, Li WF, Xu XY
Cell death discovery 2021 Jun 1;7(1):129
Cell death discovery 2021 Jun 1;7(1):129
Ubiquitin-specific protease 49 attenuates IL-1β-induced rat primary chondrocyte apoptosis by facilitating Axin deubiquitination and subsequent Wnt/β-catenin signaling cascade inhibition.
Yang L, Wang Z, Zou C, Mi Y, Tang H, Wu X
Molecular and cellular biochemistry 2020 Nov;474(1-2):263-275
Molecular and cellular biochemistry 2020 Nov;474(1-2):263-275
Differential Expression of DUB Genes in Ovarian Cells Treated with Di-2-Ethylhexyl Phthalate.
Lee DH, Park JH, Choi J, Lee KJ, Yun BS, Baek KH
International journal of molecular sciences 2020 Mar 4;21(5)
International journal of molecular sciences 2020 Mar 4;21(5)
USP49 inhibits ischemia-reperfusion-induced cell viability suppression and apoptosis in human AC16 cardiomyocytes through DUSP1-JNK1/2 signaling.
Zhang W, Zhang Y, Zhang H, Zhao Q, Liu Z, Xu Y
Journal of cellular physiology 2019 May;234(5):6529-6538
Journal of cellular physiology 2019 May;234(5):6529-6538
Ubiquitin specific peptidase 49 inhibits non-small cell lung cancer cell growth by suppressing PI3K/AKT signaling.
Shen WM, Yin JN, Xu RJ, Xu DF, Zheng SY
The Kaohsiung journal of medical sciences 2019 Jul;35(7):401-407
The Kaohsiung journal of medical sciences 2019 Jul;35(7):401-407
USP49 potently stabilizes APOBEC3G protein by removing ubiquitin and inhibits HIV-1 replication.
Pan T, Song Z, Wu L, Liu G, Ma X, Peng Z, Zhou M, Liang L, Liu B, Liu J, Zhang J, Zhang X, Huang R, Zhao J, Li Y, Ling X, Luo Y, Tang X, Cai W, Deng K, Li L, Zhang H
eLife 2019 Aug 9;8
eLife 2019 Aug 9;8
USP49 negatively regulates cellular antiviral responses via deconjugating K63-linked ubiquitination of MITA.
Ye L, Zhang Q, Liuyu T, Xu Z, Zhang MX, Luo MH, Zeng WB, Zhu Q, Lin D, Zhong B
PLoS pathogens 2019 Apr;15(4):e1007680
PLoS pathogens 2019 Apr;15(4):e1007680
USP49 negatively regulates tumorigenesis and chemoresistance through FKBP51-AKT signaling.
Luo K, Li Y, Yin Y, Li L, Wu C, Chen Y, Nowsheen S, Hu Q, Zhang L, Lou Z, Yuan J
The EMBO journal 2017 May 15;36(10):1434-1446
The EMBO journal 2017 May 15;36(10):1434-1446
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- MCF7 cells were subjected to SDS PAGE followed by western blot with 18066-1-AP(USP49 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human stomach using 18066-1-AP(USP49 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The USP49 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human USP49. This antibody recognizes human,mouse,rat antigen. The USP49 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
