BS7401

antibody from Bioworld Technology, Inc
Targeting: MTAP c86fus, MSAP
Provider product page for BS7401
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS7401 - Provider product page
Provider
Bioworld Technology, Inc
Product name
MTAP polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human MTAP.
Description
MTAP is an enzyme that is essential for the salvage pathway for both adenine and methionine synthesis. MTAP catalyzes the cleavage of 5£ª-methylthioadenosine into adenine and 5-methylthio-D-ribose-1-phosphate. Adenine is then used to generate AMP whereas 5-methylthio-D-ribose-1-phosphate is converted into methionine (1,2). MTAP is expressed in all normal cells and tissues, although frequently lost in different human tumors including pancreatic adenocarcinoma, neuroendocrine tumors, non-small cell lung carcinoma and breast carcinoma. MTAP is usually codeleted with p16 (cdkN2a/ARF) (3-5). MTAP overexpression in breast cancer cells inhibits their ability to form colonies in soft agar, thereby implicating its function as a tumor suppressor (6).
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
MTAP protein structure - BS7401 shown in red.