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Immunohistochemistry
Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [47]
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- Product number
- MA5-16406 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- Anti-Nkx2.1 Monoclonal Antibody (8G7G3/1)
- Antibody type
- Monoclonal
- Antigen
- Recombinant full-length protein
- Description
- Heat-mediated antigen retrieval is recommended prior to staining, using a 10mM citrate buffer, pH 6.0, for 10 minutes followed by cooling at room temperature for 20 min. Following antigen retrieval, incubate samples with primary antibody for 30 min at room temperature. A suggested positive control is normal thyroid or lung tissue.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- 8G7G3/1
- Vial size
- 500 µL
- Storage
- -20° C, Avoid Freeze/Thaw Cycles
Submitted references TTF-1/NKX2-1 binds to DDB1 and confers replication stress resistance to lung adenocarcinomas.
Branchial Cleft-Like Cysts Involving 3 Different Organs: Thyroid Gland, Thymus, and Parotid Gland.
Extracellular matrix defects in aneurysmal Fibulin-4 mice predispose to lung emphysema.
Influence of thyroid transcription factor-1 on fluorodeoxyglucose uptake and prognosis of non-small cell lung cancer.
On the relevance of a testing algorithm for the detection of ROS1-rearranged lung adenocarcinomas.
In search of the ideal immunopanel to distinguish metastatic mammary carcinoma from primary lung carcinoma: a tissue microarray study of 207 cases.
Adequacy of CT-guided biopsies with histomolecular subtyping of pulmonary adenocarcinomas: influence of ATS/ERS/IASLC guidelines.
High-grade lung adenocarcinoma with fetal lung-like morphology: clinicopathologic, immunohistochemical, and molecular analyses of 17 cases.
Vimentin expression predicts the occurrence of metastases in non small cell lung carcinomas.
Extraosseous benign notochordal cell tumor presenting as bilateral pulmonary nodules.
Neuroendocrine carcinoma of the stomach: morphologic and immunohistochemical characteristics and prognosis.
A fate map of the murine pancreas buds reveals a multipotent ventral foregut organ progenitor.
Genome-wide analyses of Nkx2-1 binding to transcriptional target genes uncover novel regulatory patterns conserved in lung development and tumors.
The effect of TTF-1 expression on ipsilateral mediastinal nodal (N2) metastases in primary adenocarcinoma of the lung.
Miliary brain metastases from occult lung adenocarcinoma: Radiologic and histopathologic confirmation.
Comparison of monoclonal napsin A, polyclonal napsin A, and TTF-1 for determining lung origin in metastatic adenocarcinomas.
Generation of functional thyroid from embryonic stem cells.
Is primary pulmonary meningioma a giant form of a meningothelial-like nodule? A case report and review of the literature.
TTF-1 action on the transcriptional regulation of cyclooxygenase-2 gene in the rat brain.
Specific detection of OCT3/4 isoform A/B/B1 expression in solid (germ cell) tumours and cell lines: confirmation of OCT3/4 specificity for germ cell tumours.
Subclassification of non-small cell lung carcinomas lacking morphologic differentiation on biopsy specimens: Utility of an immunohistochemical panel containing TTF-1, napsin A, p63, and CK5/6.
Combined small-cell carcinoma of the lung with quadripartite differentiation of epithelial, neuroendocrine, skeletal muscle, and myofibroblastic type.
TTF1 expression in normal lung neuroendocrine cells and related tumors: immunohistochemical study comparing two different monoclonal antibodies.
Lung-specific inactivation of CCAAT/enhancer binding protein alpha causes a pathological pattern characteristic of COPD.
Primary small cell neuroendocrine carcinoma of the kidney: morphological, immunohistochemical, ultrastructural, and cytogenetic study of a case and review of the literature.
AKR1B10 in usual interstitial pneumonia: expression in squamous metaplasia in association with smoking and lung cancer.
MASH1: a useful marker in differentiating pulmonary small cell carcinoma from Merkel cell carcinoma.
Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by beta-catenin signaling.
Diagnostic utility of thyroid transcription factors Pax8 and TTF-2 (FoxE1) in thyroid epithelial neoplasms.
Elevated phospho-S6 expression is associated with metastasis in adenocarcinoma of the lung.
Primary neuroendocrine carcinoma of the breast: a case report.
Immunohistopathological re-evaluation of adenocarcinoma of the lung with mixed subtypes using a tissue microarray technique and hierarchical clustering analysis.
The diagnostic value of TTF-1, CK 5/6, and p63 immunostaining in classification of lung carcinomas.
Prognostic model of stage II non-small cell lung cancer by a discriminant analysis of the immunohistochemical protein expression.
Papillary adenocarcinoma of the lung is a more advanced adenocarcinoma than bronchioloalveolar carcinoma that is composed of two distinct histological subtypes.
Thyroid transcription factor 1 expression in cystic lesions of the neck: an immunohistochemical investigation of thyroglossal duct cysts, branchial cleft cysts and metastatic papillary thyroid cancer.
The spectrum of pulmonary mucinous cystic neoplasia : a clinicopathologic and immunohistochemical study of ten cases and review of literature.
Pulmonary adenocarcinoma with micropapillary component: an immunohistochemical study. Case report.
CDX-2 homeobox gene product expression in neuroendocrine tumors: its role as a marker of intestinal neuroendocrine tumors.
CDX-2 homeobox gene product expression in neuroendocrine tumors: its role as a marker of intestinal neuroendocrine tumors.
Cell type-specific occurrence of caveolin-1alpha and -1beta in the lung caused by expression of distinct mRNAs.
TTF-1 and surfactant-B as co-adjuvants in the diagnosis of lung adenocarcinoma and pleural mesothelioma.
TTF-1 and surfactant-B as co-adjuvants in the diagnosis of lung adenocarcinoma and pleural mesothelioma.
Expression of thyroid transcription factor-1 in 16 human lung cancer cell lines.
Placental transmogrification of the lung is a histologic pattern frequently associated with pulmonary fibrochondromatous hamartoma.
The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium.
A model of pulmonary adenocarcinoma in transgenic mice expressing the simian virus 40 T antigen driven by the rat Calbindin-D9K (CaBP9K) promoter.
Liu Z, Yanagisawa K, Griesing S, Iwai M, Kano K, Hotta N, Kajino T, Suzuki M, Takahashi T
Oncogene 2017 Jun 29;36(26):3740-3748
Oncogene 2017 Jun 29;36(26):3740-3748
Branchial Cleft-Like Cysts Involving 3 Different Organs: Thyroid Gland, Thymus, and Parotid Gland.
Nakazawa T, Kondo T, Oishi N, Tahara I, Kasai K, Inoue T, Mochizuki K, Katoh R
Medicine 2015 Oct;94(42):e1758
Medicine 2015 Oct;94(42):e1758
Extracellular matrix defects in aneurysmal Fibulin-4 mice predispose to lung emphysema.
Ramnath NW, van de Luijtgaarden KM, van der Pluijm I, van Nimwegen M, van Heijningen PM, Swagemakers SM, van Thiel BS, Ridwan RY, van Vliet N, Vermeij M, Hawinkels LJ, de Munck A, Dzyubachyk O, Meijering E, van der Spek P, Rottier R, Yanagisawa H, Hendriks RW, Kanaar R, Rouwet EV, Kleinjan A, Essers J
PloS one 2014;9(9):e106054
PloS one 2014;9(9):e106054
Influence of thyroid transcription factor-1 on fluorodeoxyglucose uptake and prognosis of non-small cell lung cancer.
Ooi H, Chen CY, Hsiao YC, Huang WS, Hsieh BT
Anticancer research 2014 May;34(5):2467-75
Anticancer research 2014 May;34(5):2467-75
On the relevance of a testing algorithm for the detection of ROS1-rearranged lung adenocarcinomas.
Mescam-Mancini L, Lantuéjoul S, Moro-Sibilot D, Rouquette I, Souquet PJ, Audigier-Valette C, Sabourin JC, Decroisette C, Sakhri L, Brambilla E, McLeer-Florin A
Lung cancer (Amsterdam, Netherlands) 2014 Feb;83(2):168-73
Lung cancer (Amsterdam, Netherlands) 2014 Feb;83(2):168-73
In search of the ideal immunopanel to distinguish metastatic mammary carcinoma from primary lung carcinoma: a tissue microarray study of 207 cases.
Kawaguchi KR, Lu FI, Kaplan R, Liu YF, Chadwick P, Chen Z, Brogi E, Shin SJ
Applied immunohistochemistry & molecular morphology : AIMM 2014 Apr;22(4):266-74
Applied immunohistochemistry & molecular morphology : AIMM 2014 Apr;22(4):266-74
Adequacy of CT-guided biopsies with histomolecular subtyping of pulmonary adenocarcinomas: influence of ATS/ERS/IASLC guidelines.
Ferretti GR, Busser B, de Fraipont F, Reymond E, McLeer-Florin A, Mescam-Mancini L, Moro-Sibilot D, Brambilla E, Lantuejoul S
Lung cancer (Amsterdam, Netherlands) 2013 Oct;82(1):69-75
Lung cancer (Amsterdam, Netherlands) 2013 Oct;82(1):69-75
High-grade lung adenocarcinoma with fetal lung-like morphology: clinicopathologic, immunohistochemical, and molecular analyses of 17 cases.
Morita S, Yoshida A, Goto A, Ota S, Tsuta K, Yokozawa K, Asamura H, Nakajima J, Takai D, Mori M, Oka T, Tamaru J, Itoyama S, Furuta K, Fukayama M, Tsuda H
The American journal of surgical pathology 2013 Jun;37(6):924-32
The American journal of surgical pathology 2013 Jun;37(6):924-32
Vimentin expression predicts the occurrence of metastases in non small cell lung carcinomas.
Dauphin M, Barbe C, Lemaire S, Nawrocki-Raby B, Lagonotte E, Delepine G, Birembaut P, Gilles C, Polette M
Lung cancer (Amsterdam, Netherlands) 2013 Jul;81(1):117-22
Lung cancer (Amsterdam, Netherlands) 2013 Jul;81(1):117-22
Extraosseous benign notochordal cell tumor presenting as bilateral pulmonary nodules.
Lee FY, Wen MC, Wang J
Human pathology 2013 Jul;44(7):1447-51
Human pathology 2013 Jul;44(7):1447-51
Neuroendocrine carcinoma of the stomach: morphologic and immunohistochemical characteristics and prognosis.
Ishida M, Sekine S, Fukagawa T, Ohashi M, Morita S, Taniguchi H, Katai H, Tsuda H, Kushima R
The American journal of surgical pathology 2013 Jul;37(7):949-59
The American journal of surgical pathology 2013 Jul;37(7):949-59
A fate map of the murine pancreas buds reveals a multipotent ventral foregut organ progenitor.
Angelo JR, Guerrero-Zayas MI, Tremblay KD
PloS one 2012;7(7):e40707
PloS one 2012;7(7):e40707
Genome-wide analyses of Nkx2-1 binding to transcriptional target genes uncover novel regulatory patterns conserved in lung development and tumors.
Tagne JB, Gupta S, Gower AC, Shen SS, Varma S, Lakshminarayanan M, Cao Y, Spira A, Volkert TL, Ramirez MI
PloS one 2012;7(1):e29907
PloS one 2012;7(1):e29907
The effect of TTF-1 expression on ipsilateral mediastinal nodal (N2) metastases in primary adenocarcinoma of the lung.
Samancilar O, Kaya SO, Ceylan KC, Usluer O, Yener AG
Contemporary oncology (Poznan, Poland) 2012;16(6):516-9
Contemporary oncology (Poznan, Poland) 2012;16(6):516-9
Miliary brain metastases from occult lung adenocarcinoma: Radiologic and histopathologic confirmation.
Kahveci R, Gürer B, Kaygusuz G, Sekerci Z
Journal of neurosciences in rural practice 2012 Sep;3(3):386-9
Journal of neurosciences in rural practice 2012 Sep;3(3):386-9
Comparison of monoclonal napsin A, polyclonal napsin A, and TTF-1 for determining lung origin in metastatic adenocarcinomas.
Mukhopadhyay S, Katzenstein AL
American journal of clinical pathology 2012 Nov;138(5):703-11
American journal of clinical pathology 2012 Nov;138(5):703-11
Generation of functional thyroid from embryonic stem cells.
Antonica F, Kasprzyk DF, Opitz R, Iacovino M, Liao XH, Dumitrescu AM, Refetoff S, Peremans K, Manto M, Kyba M, Costagliola S
Nature 2012 Nov 1;491(7422):66-71
Nature 2012 Nov 1;491(7422):66-71
Is primary pulmonary meningioma a giant form of a meningothelial-like nodule? A case report and review of the literature.
Masago K, Hosada W, Sasaki E, Murakami Y, Sugano M, Nagasaka T, Yamada M, Yatabe Y
Case reports in oncology 2012 May;5(2):471-8
Case reports in oncology 2012 May;5(2):471-8
TTF-1 action on the transcriptional regulation of cyclooxygenase-2 gene in the rat brain.
Yun CH, Kim JG, Park BS, Lee HM, Kim DH, Kim EO, Park JJ, Park JW, Damante G, Kim YI, Lee BJ
PloS one 2011;6(12):e28959
PloS one 2011;6(12):e28959
Specific detection of OCT3/4 isoform A/B/B1 expression in solid (germ cell) tumours and cell lines: confirmation of OCT3/4 specificity for germ cell tumours.
Rijlaarsdam MA, van Herk HA, Gillis AJ, Stoop H, Jenster G, Martens J, van Leenders GJ, Dinjens W, Hoogland AM, Timmermans M, Looijenga LH
British journal of cancer 2011 Sep 6;105(6):854-63
British journal of cancer 2011 Sep 6;105(6):854-63
Subclassification of non-small cell lung carcinomas lacking morphologic differentiation on biopsy specimens: Utility of an immunohistochemical panel containing TTF-1, napsin A, p63, and CK5/6.
Mukhopadhyay S, Katzenstein AL
The American journal of surgical pathology 2011 Jan;35(1):15-25
The American journal of surgical pathology 2011 Jan;35(1):15-25
Combined small-cell carcinoma of the lung with quadripartite differentiation of epithelial, neuroendocrine, skeletal muscle, and myofibroblastic type.
Pelosi G, Sonzogni A, Galetta D, Perrone F, Braidotti P, Manzotti M, Fabbri A, Spaggiari L, Veronesi G, Viale G
Virchows Archiv : an international journal of pathology 2011 Apr;458(4):497-503
Virchows Archiv : an international journal of pathology 2011 Apr;458(4):497-503
TTF1 expression in normal lung neuroendocrine cells and related tumors: immunohistochemical study comparing two different monoclonal antibodies.
La Rosa S, Chiaravalli AM, Placidi C, Papanikolaou N, Cerati M, Capella C
Virchows Archiv : an international journal of pathology 2010 Oct;457(4):497-507
Virchows Archiv : an international journal of pathology 2010 Oct;457(4):497-507
Lung-specific inactivation of CCAAT/enhancer binding protein alpha causes a pathological pattern characteristic of COPD.
Didon L, Roos AB, Elmberger GP, Gonzalez FJ, Nord M
The European respiratory journal 2010 Jan;35(1):186-97
The European respiratory journal 2010 Jan;35(1):186-97
Primary small cell neuroendocrine carcinoma of the kidney: morphological, immunohistochemical, ultrastructural, and cytogenetic study of a case and review of the literature.
La Rosa S, Bernasconi B, Micello D, Finzi G, Capella C
Endocrine pathology 2009 Spring;20(1):24-34
Endocrine pathology 2009 Spring;20(1):24-34
AKR1B10 in usual interstitial pneumonia: expression in squamous metaplasia in association with smoking and lung cancer.
Li CP, Goto A, Watanabe A, Murata K, Ota S, Niki T, Aburatani H, Fukayama M
Pathology, research and practice 2008;204(5):295-304
Pathology, research and practice 2008;204(5):295-304
MASH1: a useful marker in differentiating pulmonary small cell carcinoma from Merkel cell carcinoma.
Ralston J, Chiriboga L, Nonaka D
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2008 Nov;21(11):1357-62
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2008 Nov;21(11):1357-62
Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by beta-catenin signaling.
De Langhe SP, Carraro G, Tefft D, Li C, Xu X, Chai Y, Minoo P, Hajihosseini MK, Drouin J, Kaartinen V, Bellusci S
PloS one 2008 Jan 30;3(1):e1516
PloS one 2008 Jan 30;3(1):e1516
Diagnostic utility of thyroid transcription factors Pax8 and TTF-2 (FoxE1) in thyroid epithelial neoplasms.
Nonaka D, Tang Y, Chiriboga L, Rivera M, Ghossein R
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2008 Feb;21(2):192-200
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2008 Feb;21(2):192-200
Elevated phospho-S6 expression is associated with metastasis in adenocarcinoma of the lung.
McDonald JM, Pelloski CE, Ledoux A, Sun M, Raso G, Komaki R, Wistuba II, Bekele BN, Aldape K
Clinical cancer research : an official journal of the American Association for Cancer Research 2008 Dec 1;14(23):7832-7
Clinical cancer research : an official journal of the American Association for Cancer Research 2008 Dec 1;14(23):7832-7
Primary neuroendocrine carcinoma of the breast: a case report.
Yaren A, Kelten C, Akbulut M, Teke Z, Duzcan E, Erdem E
Tumori 2007 Sep-Oct;93(5):496-8
Tumori 2007 Sep-Oct;93(5):496-8
Immunohistopathological re-evaluation of adenocarcinoma of the lung with mixed subtypes using a tissue microarray technique and hierarchical clustering analysis.
Gamal G, Sano T, Sakurai S, Kawashima O, Sugano M, Nakajima T
Pathology international 2007 Dec;57(12):765-74
Pathology international 2007 Dec;57(12):765-74
The diagnostic value of TTF-1, CK 5/6, and p63 immunostaining in classification of lung carcinomas.
Kargi A, Gurel D, Tuna B
Applied immunohistochemistry & molecular morphology : AIMM 2007 Dec;15(4):415-20
Applied immunohistochemistry & molecular morphology : AIMM 2007 Dec;15(4):415-20
Prognostic model of stage II non-small cell lung cancer by a discriminant analysis of the immunohistochemical protein expression.
Kohri T, Sugano M, Kawashima O, Saito R, Sakurai S, Sano T, Nakajima T
Surgery today 2006;36(12):1039-46
Surgery today 2006;36(12):1039-46
Papillary adenocarcinoma of the lung is a more advanced adenocarcinoma than bronchioloalveolar carcinoma that is composed of two distinct histological subtypes.
Jian Z, Tomizawa Y, Yanagitani N, Iijima H, Sano T, Nakajima T
Pathology international 2005 Oct;55(10):619-25
Pathology international 2005 Oct;55(10):619-25
Thyroid transcription factor 1 expression in cystic lesions of the neck: an immunohistochemical investigation of thyroglossal duct cysts, branchial cleft cysts and metastatic papillary thyroid cancer.
Kreft A, Hansen T, Kirkpatrick CJ
Virchows Archiv : an international journal of pathology 2005 Jul;447(1):9-11
Virchows Archiv : an international journal of pathology 2005 Jul;447(1):9-11
The spectrum of pulmonary mucinous cystic neoplasia : a clinicopathologic and immunohistochemical study of ten cases and review of literature.
Gao ZH, Urbanski SJ
American journal of clinical pathology 2005 Jul;124(1):62-70
American journal of clinical pathology 2005 Jul;124(1):62-70
Pulmonary adenocarcinoma with micropapillary component: an immunohistochemical study. Case report.
Kuroda N, Hamauzu T, Toi M, Yamaoka K, Miyazaki E, Hiroi M, Nakata H, Taguchi H, Enzan H
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2005 Jul-Aug;113(7-8):550-4
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2005 Jul-Aug;113(7-8):550-4
CDX-2 homeobox gene product expression in neuroendocrine tumors: its role as a marker of intestinal neuroendocrine tumors.
Barbareschi M, Roldo C, Zamboni G, Capelli P, Cavazza A, Macri E, Cangi MG, Chilosi M, Doglioni C
The American journal of surgical pathology 2004 Sep;28(9):1169-76
The American journal of surgical pathology 2004 Sep;28(9):1169-76
CDX-2 homeobox gene product expression in neuroendocrine tumors: its role as a marker of intestinal neuroendocrine tumors.
Barbareschi M, Roldo C, Zamboni G, Capelli P, Cavazza A, Macri E, Cangi MG, Chilosi M, Doglioni C
The American journal of surgical pathology 2004 Sep;28(9):1169-76
The American journal of surgical pathology 2004 Sep;28(9):1169-76
Cell type-specific occurrence of caveolin-1alpha and -1beta in the lung caused by expression of distinct mRNAs.
Kogo H, Aiba T, Fujimoto T
The Journal of biological chemistry 2004 Jun 11;279(24):25574-81
The Journal of biological chemistry 2004 Jun 11;279(24):25574-81
TTF-1 and surfactant-B as co-adjuvants in the diagnosis of lung adenocarcinoma and pleural mesothelioma.
Bakir K, Koçer NE, Deniz H, Güldür ME
Annals of diagnostic pathology 2004 Dec;8(6):337-41
Annals of diagnostic pathology 2004 Dec;8(6):337-41
TTF-1 and surfactant-B as co-adjuvants in the diagnosis of lung adenocarcinoma and pleural mesothelioma.
Bakir K, Koçer NE, Deniz H, Güldür ME
Annals of diagnostic pathology 2004 Dec;8(6):337-41
Annals of diagnostic pathology 2004 Dec;8(6):337-41
Expression of thyroid transcription factor-1 in 16 human lung cancer cell lines.
Fujita J, Ohtsuki Y, Bandoh S, Ueda Y, Kubo A, Tojo Y, Yamaji Y, Ishida T
Lung cancer (Amsterdam, Netherlands) 2003 Jan;39(1):31-6
Lung cancer (Amsterdam, Netherlands) 2003 Jan;39(1):31-6
Placental transmogrification of the lung is a histologic pattern frequently associated with pulmonary fibrochondromatous hamartoma.
Xu R, Murray M, Jagirdar J, Delgado Y, Melamed J
Archives of pathology & laboratory medicine 2002 May;126(5):562-6
Archives of pathology & laboratory medicine 2002 May;126(5):562-6
The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium.
Weidenfeld J, Shu W, Zhang L, Millar SE, Morrisey EE
The Journal of biological chemistry 2002 Jun 7;277(23):21061-70
The Journal of biological chemistry 2002 Jun 7;277(23):21061-70
A model of pulmonary adenocarcinoma in transgenic mice expressing the simian virus 40 T antigen driven by the rat Calbindin-D9K (CaBP9K) promoter.
Chailley-Heu B, Rambaud C, Barlier-Mur AM, Galateau-Salle F, Perret C, Capron F, Lacaze-Masmonteil T
The Journal of pathology 2001 Nov;195(4):482-9
The Journal of pathology 2001 Nov;195(4):482-9
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