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ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
- References [48]
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- Validations
- Immunohistochemistry [2]
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- Product number
- MA5-13958 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- Nkx2.1 Monoclonal Antibody (8G7G3/1), Biotin
- Antibody type
- Monoclonal
- Antigen
- Recombinant full-length protein
- Description
- MA5-13958 targets Thyroid Transcription Factor 1 in IF and IHC (P) applications and shows reactivity with Human, mouse, and Rat samples. The MA5-13958 immunogen is rat TTF-1 recombinant protein.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Conjugate
- Biotin
- Isotype
- IgG
- Antibody clone number
- 8G7G3/1
- Vial size
- 500 µL
- Concentration
- 0.2 mg/mL
- Storage
- 4° C
Submitted references Influence of thyroid transcription factor-1 on fluorodeoxyglucose uptake and prognosis of non-small cell lung cancer.
On the relevance of a testing algorithm for the detection of ROS1-rearranged lung adenocarcinomas.
In search of the ideal immunopanel to distinguish metastatic mammary carcinoma from primary lung carcinoma: a tissue microarray study of 207 cases.
Adequacy of CT-guided biopsies with histomolecular subtyping of pulmonary adenocarcinomas: influence of ATS/ERS/IASLC guidelines.
High-grade lung adenocarcinoma with fetal lung-like morphology: clinicopathologic, immunohistochemical, and molecular analyses of 17 cases.
Neuroendocrine carcinoma of the stomach: morphologic and immunohistochemical characteristics and prognosis.
Genome-wide analyses of Nkx2-1 binding to transcriptional target genes uncover novel regulatory patterns conserved in lung development and tumors.
Miliary brain metastases from occult lung adenocarcinoma: Radiologic and histopathologic confirmation.
Is primary pulmonary meningioma a giant form of a meningothelial-like nodule? A case report and review of the literature.
Implantation of fetal rat lung fragments into bleomycin-induced pulmonary fibrosis.
Primary pure squamous cell carcinoma of the thyroid: report and histogenic consideration of a case involving a BRAF mutation.
Specific detection of OCT3/4 isoform A/B/B1 expression in solid (germ cell) tumours and cell lines: confirmation of OCT3/4 specificity for germ cell tumours.
Subclassification of non-small cell lung carcinomas lacking morphologic differentiation on biopsy specimens: Utility of an immunohistochemical panel containing TTF-1, napsin A, p63, and CK5/6.
Combined small-cell carcinoma of the lung with quadripartite differentiation of epithelial, neuroendocrine, skeletal muscle, and myofibroblastic type.
TTF1 expression in normal lung neuroendocrine cells and related tumors: immunohistochemical study comparing two different monoclonal antibodies.
Primary adenomyoepithelioma of the sellar region: a case report.
Effect of oxygen on the expression of hypoxia-inducible factors in human fetal lung explants.
Lung-specific inactivation of CCAAT/enhancer binding protein alpha causes a pathological pattern characteristic of COPD.
Primary small cell neuroendocrine carcinoma of the kidney: morphological, immunohistochemical, ultrastructural, and cytogenetic study of a case and review of the literature.
Application of immunocytochemistry to the diagnosis of primary epithelioid angiosarcoma of the lung.
Clinical relevance of neuroendocrine differentiation in non-small cell lung cancer assessed by immunohistochemistry: a retrospective study on 405 surgically resected cases.
AKR1B10 in usual interstitial pneumonia: expression in squamous metaplasia in association with smoking and lung cancer.
MASH1: a useful marker in differentiating pulmonary small cell carcinoma from Merkel cell carcinoma.
Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by beta-catenin signaling.
Diagnostic utility of thyroid transcription factors Pax8 and TTF-2 (FoxE1) in thyroid epithelial neoplasms.
Elevated phospho-S6 expression is associated with metastasis in adenocarcinoma of the lung.
Primary neuroendocrine carcinoma of the breast: a case report.
Primary neuroendocrine carcinoma of the breast: a case report.
Developmental origin and identity of song system neurons born during vocal learning in songbirds.
Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm.
Immunohistopathological re-evaluation of adenocarcinoma of the lung with mixed subtypes using a tissue microarray technique and hierarchical clustering analysis.
Invasive micropapillary carcinoma of the colon: an immunohistochemical study.
The diagnostic value of TTF-1, CK 5/6, and p63 immunostaining in classification of lung carcinomas.
Prognostic model of stage II non-small cell lung cancer by a discriminant analysis of the immunohistochemical protein expression.
Alterations in alveolar epithelium differentiation and vasculogenesis in lungs of LIF/IGF-I double deficient embryos.
Thyroid transcription factor 1 expression in cystic lesions of the neck: an immunohistochemical investigation of thyroglossal duct cysts, branchial cleft cysts and metastatic papillary thyroid cancer.
Thyroid transcription factor 1 rescues PAX8/p300 synergism impaired by a natural PAX8 paired domain mutation with dominant negative activity.
The spectrum of pulmonary mucinous cystic neoplasia : a clinicopathologic and immunohistochemical study of ten cases and review of literature.
Pulmonary adenocarcinoma with micropapillary component: an immunohistochemical study. Case report.
CDX-2 homeobox gene product expression in neuroendocrine tumors: its role as a marker of intestinal neuroendocrine tumors.
CDX-2 homeobox gene product expression in neuroendocrine tumors: its role as a marker of intestinal neuroendocrine tumors.
TTF-1 and surfactant-B as co-adjuvants in the diagnosis of lung adenocarcinoma and pleural mesothelioma.
TTF-1 and surfactant-B as co-adjuvants in the diagnosis of lung adenocarcinoma and pleural mesothelioma.
The paired domain-containing factor Pax8 and the homeodomain-containing factor TTF-1 directly interact and synergistically activate transcription.
CDX-2 homeobox gene expression is a reliable marker of colorectal adenocarcinoma metastases to the lungs.
CDX-2 homeobox gene expression is a reliable marker of colorectal adenocarcinoma metastases to the lungs.
Placental transmogrification of the lung is a histologic pattern frequently associated with pulmonary fibrochondromatous hamartoma.
Immunostaining for thyroid transcription factor 1 and cytokeratin 20 aids the distinction of small cell carcinoma from Merkel cell carcinoma, but not pulmonary from extrapulmonary small cell carcinomas.
Ooi H, Chen CY, Hsiao YC, Huang WS, Hsieh BT
Anticancer research 2014 May;34(5):2467-75
Anticancer research 2014 May;34(5):2467-75
On the relevance of a testing algorithm for the detection of ROS1-rearranged lung adenocarcinomas.
Mescam-Mancini L, Lantuéjoul S, Moro-Sibilot D, Rouquette I, Souquet PJ, Audigier-Valette C, Sabourin JC, Decroisette C, Sakhri L, Brambilla E, McLeer-Florin A
Lung cancer (Amsterdam, Netherlands) 2014 Feb;83(2):168-73
Lung cancer (Amsterdam, Netherlands) 2014 Feb;83(2):168-73
In search of the ideal immunopanel to distinguish metastatic mammary carcinoma from primary lung carcinoma: a tissue microarray study of 207 cases.
Kawaguchi KR, Lu FI, Kaplan R, Liu YF, Chadwick P, Chen Z, Brogi E, Shin SJ
Applied immunohistochemistry & molecular morphology : AIMM 2014 Apr;22(4):266-74
Applied immunohistochemistry & molecular morphology : AIMM 2014 Apr;22(4):266-74
Adequacy of CT-guided biopsies with histomolecular subtyping of pulmonary adenocarcinomas: influence of ATS/ERS/IASLC guidelines.
Ferretti GR, Busser B, de Fraipont F, Reymond E, McLeer-Florin A, Mescam-Mancini L, Moro-Sibilot D, Brambilla E, Lantuejoul S
Lung cancer (Amsterdam, Netherlands) 2013 Oct;82(1):69-75
Lung cancer (Amsterdam, Netherlands) 2013 Oct;82(1):69-75
High-grade lung adenocarcinoma with fetal lung-like morphology: clinicopathologic, immunohistochemical, and molecular analyses of 17 cases.
Morita S, Yoshida A, Goto A, Ota S, Tsuta K, Yokozawa K, Asamura H, Nakajima J, Takai D, Mori M, Oka T, Tamaru J, Itoyama S, Furuta K, Fukayama M, Tsuda H
The American journal of surgical pathology 2013 Jun;37(6):924-32
The American journal of surgical pathology 2013 Jun;37(6):924-32
Neuroendocrine carcinoma of the stomach: morphologic and immunohistochemical characteristics and prognosis.
Ishida M, Sekine S, Fukagawa T, Ohashi M, Morita S, Taniguchi H, Katai H, Tsuda H, Kushima R
The American journal of surgical pathology 2013 Jul;37(7):949-59
The American journal of surgical pathology 2013 Jul;37(7):949-59
Genome-wide analyses of Nkx2-1 binding to transcriptional target genes uncover novel regulatory patterns conserved in lung development and tumors.
Tagne JB, Gupta S, Gower AC, Shen SS, Varma S, Lakshminarayanan M, Cao Y, Spira A, Volkert TL, Ramirez MI
PloS one 2012;7(1):e29907
PloS one 2012;7(1):e29907
Miliary brain metastases from occult lung adenocarcinoma: Radiologic and histopathologic confirmation.
Kahveci R, Gürer B, Kaygusuz G, Sekerci Z
Journal of neurosciences in rural practice 2012 Sep;3(3):386-9
Journal of neurosciences in rural practice 2012 Sep;3(3):386-9
Is primary pulmonary meningioma a giant form of a meningothelial-like nodule? A case report and review of the literature.
Masago K, Hosada W, Sasaki E, Murakami Y, Sugano M, Nagasaka T, Yamada M, Yatabe Y
Case reports in oncology 2012 May;5(2):471-8
Case reports in oncology 2012 May;5(2):471-8
Implantation of fetal rat lung fragments into bleomycin-induced pulmonary fibrosis.
Toba H, Sakiyama S, Kenzaki K, Kawakami Y, Uyama K, Bando Y, Tangoku A
The Journal of thoracic and cardiovascular surgery 2012 Jun;143(6):1429-35
The Journal of thoracic and cardiovascular surgery 2012 Jun;143(6):1429-35
Primary pure squamous cell carcinoma of the thyroid: report and histogenic consideration of a case involving a BRAF mutation.
Ko YS, Hwang TS, Han HS, Lim SD, Kim WS, Oh SY
Pathology international 2012 Jan;62(1):43-8
Pathology international 2012 Jan;62(1):43-8
Specific detection of OCT3/4 isoform A/B/B1 expression in solid (germ cell) tumours and cell lines: confirmation of OCT3/4 specificity for germ cell tumours.
Rijlaarsdam MA, van Herk HA, Gillis AJ, Stoop H, Jenster G, Martens J, van Leenders GJ, Dinjens W, Hoogland AM, Timmermans M, Looijenga LH
British journal of cancer 2011 Sep 6;105(6):854-63
British journal of cancer 2011 Sep 6;105(6):854-63
Subclassification of non-small cell lung carcinomas lacking morphologic differentiation on biopsy specimens: Utility of an immunohistochemical panel containing TTF-1, napsin A, p63, and CK5/6.
Mukhopadhyay S, Katzenstein AL
The American journal of surgical pathology 2011 Jan;35(1):15-25
The American journal of surgical pathology 2011 Jan;35(1):15-25
Combined small-cell carcinoma of the lung with quadripartite differentiation of epithelial, neuroendocrine, skeletal muscle, and myofibroblastic type.
Pelosi G, Sonzogni A, Galetta D, Perrone F, Braidotti P, Manzotti M, Fabbri A, Spaggiari L, Veronesi G, Viale G
Virchows Archiv : an international journal of pathology 2011 Apr;458(4):497-503
Virchows Archiv : an international journal of pathology 2011 Apr;458(4):497-503
TTF1 expression in normal lung neuroendocrine cells and related tumors: immunohistochemical study comparing two different monoclonal antibodies.
La Rosa S, Chiaravalli AM, Placidi C, Papanikolaou N, Cerati M, Capella C
Virchows Archiv : an international journal of pathology 2010 Oct;457(4):497-507
Virchows Archiv : an international journal of pathology 2010 Oct;457(4):497-507
Primary adenomyoepithelioma of the sellar region: a case report.
Rychly B, Kazakov DV, Danis D, Szep Z, Michal M
The American journal of surgical pathology 2010 Oct;34(10):1550-4
The American journal of surgical pathology 2010 Oct;34(10):1550-4
Effect of oxygen on the expression of hypoxia-inducible factors in human fetal lung explants.
Rajatapiti P, de Rooij JD, Beurskens LW, Keijzer R, Tibboel D, Rottier RJ, de Krijger RR
Neonatology 2010 Jun;97(4):346-54
Neonatology 2010 Jun;97(4):346-54
Lung-specific inactivation of CCAAT/enhancer binding protein alpha causes a pathological pattern characteristic of COPD.
Didon L, Roos AB, Elmberger GP, Gonzalez FJ, Nord M
The European respiratory journal 2010 Jan;35(1):186-97
The European respiratory journal 2010 Jan;35(1):186-97
Primary small cell neuroendocrine carcinoma of the kidney: morphological, immunohistochemical, ultrastructural, and cytogenetic study of a case and review of the literature.
La Rosa S, Bernasconi B, Micello D, Finzi G, Capella C
Endocrine pathology 2009 Spring;20(1):24-34
Endocrine pathology 2009 Spring;20(1):24-34
Application of immunocytochemistry to the diagnosis of primary epithelioid angiosarcoma of the lung.
Kuroda N, Hamaguchi N, Inoue K, Ohara M, Mizuno K, Hayashi Y, Lee GH
Medical molecular morphology 2009 Dec;42(4):250-3
Medical molecular morphology 2009 Dec;42(4):250-3
Clinical relevance of neuroendocrine differentiation in non-small cell lung cancer assessed by immunohistochemistry: a retrospective study on 405 surgically resected cases.
Sterlacci W, Fiegl M, Hilbe W, Auberger J, Mikuz G, Tzankov A
Virchows Archiv : an international journal of pathology 2009 Aug;455(2):125-32
Virchows Archiv : an international journal of pathology 2009 Aug;455(2):125-32
AKR1B10 in usual interstitial pneumonia: expression in squamous metaplasia in association with smoking and lung cancer.
Li CP, Goto A, Watanabe A, Murata K, Ota S, Niki T, Aburatani H, Fukayama M
Pathology, research and practice 2008;204(5):295-304
Pathology, research and practice 2008;204(5):295-304
MASH1: a useful marker in differentiating pulmonary small cell carcinoma from Merkel cell carcinoma.
Ralston J, Chiriboga L, Nonaka D
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2008 Nov;21(11):1357-62
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2008 Nov;21(11):1357-62
Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by beta-catenin signaling.
De Langhe SP, Carraro G, Tefft D, Li C, Xu X, Chai Y, Minoo P, Hajihosseini MK, Drouin J, Kaartinen V, Bellusci S
PloS one 2008 Jan 30;3(1):e1516
PloS one 2008 Jan 30;3(1):e1516
Diagnostic utility of thyroid transcription factors Pax8 and TTF-2 (FoxE1) in thyroid epithelial neoplasms.
Nonaka D, Tang Y, Chiriboga L, Rivera M, Ghossein R
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2008 Feb;21(2):192-200
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2008 Feb;21(2):192-200
Elevated phospho-S6 expression is associated with metastasis in adenocarcinoma of the lung.
McDonald JM, Pelloski CE, Ledoux A, Sun M, Raso G, Komaki R, Wistuba II, Bekele BN, Aldape K
Clinical cancer research : an official journal of the American Association for Cancer Research 2008 Dec 1;14(23):7832-7
Clinical cancer research : an official journal of the American Association for Cancer Research 2008 Dec 1;14(23):7832-7
Primary neuroendocrine carcinoma of the breast: a case report.
Yaren A, Kelten C, Akbulut M, Teke Z, Duzcan E, Erdem E
Tumori 2007 Sep-Oct;93(5):496-8
Tumori 2007 Sep-Oct;93(5):496-8
Primary neuroendocrine carcinoma of the breast: a case report.
Yaren A, Kelten C, Akbulut M, Teke Z, Duzcan E, Erdem E
Tumori 2007 Sep-Oct;93(5):496-8
Tumori 2007 Sep-Oct;93(5):496-8
Developmental origin and identity of song system neurons born during vocal learning in songbirds.
Scott BB, Lois C
The Journal of comparative neurology 2007 May 10;502(2):202-14
The Journal of comparative neurology 2007 May 10;502(2):202-14
Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm.
Que J, Okubo T, Goldenring JR, Nam KT, Kurotani R, Morrisey EE, Taranova O, Pevny LH, Hogan BL
Development (Cambridge, England) 2007 Jul;134(13):2521-31
Development (Cambridge, England) 2007 Jul;134(13):2521-31
Immunohistopathological re-evaluation of adenocarcinoma of the lung with mixed subtypes using a tissue microarray technique and hierarchical clustering analysis.
Gamal G, Sano T, Sakurai S, Kawashima O, Sugano M, Nakajima T
Pathology international 2007 Dec;57(12):765-74
Pathology international 2007 Dec;57(12):765-74
Invasive micropapillary carcinoma of the colon: an immunohistochemical study.
Kuroda N, Oonishi K, Ohara M, Hirouchi T, Mizuno K, Hayashi Y, Lee GH
Medical molecular morphology 2007 Dec;40(4):226-30
Medical molecular morphology 2007 Dec;40(4):226-30
The diagnostic value of TTF-1, CK 5/6, and p63 immunostaining in classification of lung carcinomas.
Kargi A, Gurel D, Tuna B
Applied immunohistochemistry & molecular morphology : AIMM 2007 Dec;15(4):415-20
Applied immunohistochemistry & molecular morphology : AIMM 2007 Dec;15(4):415-20
Prognostic model of stage II non-small cell lung cancer by a discriminant analysis of the immunohistochemical protein expression.
Kohri T, Sugano M, Kawashima O, Saito R, Sakurai S, Sano T, Nakajima T
Surgery today 2006;36(12):1039-46
Surgery today 2006;36(12):1039-46
Alterations in alveolar epithelium differentiation and vasculogenesis in lungs of LIF/IGF-I double deficient embryos.
Moreno-Barriuso N, López-Malpartida AV, de Pablo F, Pichel JG
Developmental dynamics : an official publication of the American Association of Anatomists 2006 Aug;235(8):2040-50
Developmental dynamics : an official publication of the American Association of Anatomists 2006 Aug;235(8):2040-50
Thyroid transcription factor 1 expression in cystic lesions of the neck: an immunohistochemical investigation of thyroglossal duct cysts, branchial cleft cysts and metastatic papillary thyroid cancer.
Kreft A, Hansen T, Kirkpatrick CJ
Virchows Archiv : an international journal of pathology 2005 Jul;447(1):9-11
Virchows Archiv : an international journal of pathology 2005 Jul;447(1):9-11
Thyroid transcription factor 1 rescues PAX8/p300 synergism impaired by a natural PAX8 paired domain mutation with dominant negative activity.
Grasberger H, Ringkananont U, Lefrancois P, Abramowicz M, Vassart G, Refetoff S
Molecular endocrinology (Baltimore, Md.) 2005 Jul;19(7):1779-91
Molecular endocrinology (Baltimore, Md.) 2005 Jul;19(7):1779-91
The spectrum of pulmonary mucinous cystic neoplasia : a clinicopathologic and immunohistochemical study of ten cases and review of literature.
Gao ZH, Urbanski SJ
American journal of clinical pathology 2005 Jul;124(1):62-70
American journal of clinical pathology 2005 Jul;124(1):62-70
Pulmonary adenocarcinoma with micropapillary component: an immunohistochemical study. Case report.
Kuroda N, Hamauzu T, Toi M, Yamaoka K, Miyazaki E, Hiroi M, Nakata H, Taguchi H, Enzan H
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2005 Jul-Aug;113(7-8):550-4
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2005 Jul-Aug;113(7-8):550-4
CDX-2 homeobox gene product expression in neuroendocrine tumors: its role as a marker of intestinal neuroendocrine tumors.
Barbareschi M, Roldo C, Zamboni G, Capelli P, Cavazza A, Macri E, Cangi MG, Chilosi M, Doglioni C
The American journal of surgical pathology 2004 Sep;28(9):1169-76
The American journal of surgical pathology 2004 Sep;28(9):1169-76
CDX-2 homeobox gene product expression in neuroendocrine tumors: its role as a marker of intestinal neuroendocrine tumors.
Barbareschi M, Roldo C, Zamboni G, Capelli P, Cavazza A, Macri E, Cangi MG, Chilosi M, Doglioni C
The American journal of surgical pathology 2004 Sep;28(9):1169-76
The American journal of surgical pathology 2004 Sep;28(9):1169-76
TTF-1 and surfactant-B as co-adjuvants in the diagnosis of lung adenocarcinoma and pleural mesothelioma.
Bakir K, Koçer NE, Deniz H, Güldür ME
Annals of diagnostic pathology 2004 Dec;8(6):337-41
Annals of diagnostic pathology 2004 Dec;8(6):337-41
TTF-1 and surfactant-B as co-adjuvants in the diagnosis of lung adenocarcinoma and pleural mesothelioma.
Bakir K, Koçer NE, Deniz H, Güldür ME
Annals of diagnostic pathology 2004 Dec;8(6):337-41
Annals of diagnostic pathology 2004 Dec;8(6):337-41
The paired domain-containing factor Pax8 and the homeodomain-containing factor TTF-1 directly interact and synergistically activate transcription.
Di Palma T, Nitsch R, Mascia A, Nitsch L, Di Lauro R, Zannini M
The Journal of biological chemistry 2003 Jan 31;278(5):3395-402
The Journal of biological chemistry 2003 Jan 31;278(5):3395-402
CDX-2 homeobox gene expression is a reliable marker of colorectal adenocarcinoma metastases to the lungs.
Barbareschi M, Murer B, Colby TV, Chilosi M, Macri E, Loda M, Doglioni C
The American journal of surgical pathology 2003 Feb;27(2):141-9
The American journal of surgical pathology 2003 Feb;27(2):141-9
CDX-2 homeobox gene expression is a reliable marker of colorectal adenocarcinoma metastases to the lungs.
Barbareschi M, Murer B, Colby TV, Chilosi M, Macri E, Loda M, Doglioni C
The American journal of surgical pathology 2003 Feb;27(2):141-9
The American journal of surgical pathology 2003 Feb;27(2):141-9
Placental transmogrification of the lung is a histologic pattern frequently associated with pulmonary fibrochondromatous hamartoma.
Xu R, Murray M, Jagirdar J, Delgado Y, Melamed J
Archives of pathology & laboratory medicine 2002 May;126(5):562-6
Archives of pathology & laboratory medicine 2002 May;126(5):562-6
Immunostaining for thyroid transcription factor 1 and cytokeratin 20 aids the distinction of small cell carcinoma from Merkel cell carcinoma, but not pulmonary from extrapulmonary small cell carcinomas.
Cheuk W, Kwan MY, Suster S, Chan JK
Archives of pathology & laboratory medicine 2001 Feb;125(2):228-31
Archives of pathology & laboratory medicine 2001 Feb;125(2):228-31
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Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Formalin-fixed, paraffin-embedded human lung carcinoma stained with TTF-1 antibody using peroxidase-conjugate and AEC chromogen. Note nuclear staining of tumor cells.
- Conjugate
- Biotin
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Formalin-fixed, paraffin-embedded rat lung stained with TTF-1 antibody using peroxidase-conjugate and AEC chromogen. Note nuclear staining of alveolar epithelial cells.
- Conjugate
- Biotin
