Antibody data
- Antibody Data
- Antigen structure
- References [59]
- Comments [0]
- Validations
- Western blot [1]
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- Product number
- 25413-1-AP - Provider product page

- Provider
- Proteintech Group
- Product name
- G6PD antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated G6PD antibody (Cat. #25413-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Identification of the Antioxidant Enzyme B166 as a Novel Biomarker for Patients With Glioblastoma Multiforme.
Jiedu Quyu Ziyin prescription alleviated renal injury in MRL/lpr by inhibiting PPP-mediated oxidative stress through regulating p53/G6PD/NOX pathway.
Synergistic regulation of SLC7A11 and glucose-6-phosphate dehydrogenase in redox homeostasis governs decidualization: a mechanistic insight into adenomyosis-related infertility.
Developmental lead exposure induces neurotoxicity via glycolytic failure, glial activation, and miR-144 downregulation in male rat offspring.
Exploration of the relationship between apoptosis related characteristic genes and the prognosis of HCC.
The lactylation of glucose-6-phosphate dehydrogenase promotes malignant phenotypes in cancer cell lines.
Mechanistic insights into metformin's anti-hyperuricemic effect: Targeting PPP/DNPB/XOD-mediated purine pathway, purinosome assembly, and gut microbiota homostasis in rats.
Pentose phosphate recycling driven by Gli1 contributes to chemotherapy resistance in cancer cells.
CDK5-triggered G6PD phosphorylation at threonine 91 facilitating redox homeostasis reveals a vulnerability in breast cancer.
Chronic exposure to polyethylene terephthalate microplastics induces gut microbiota dysbiosis and disordered hepatic lipid metabolism in mice.
Matrix stiffness regulates glucose-6-phosphate dehydrogenase expression to mediate sorafenib resistance in hepatocellular carcinoma through the ITGB1-PI3K/AKT pathway.
Targeting Metabolic Adaptation of Colorectal Cancer with Vanadium-Doped Nanosystem to Enhance Chemotherapy and Immunotherapy.
Porcine reproductive and respiratory syndrome virus activates the pentose phosphate pathway via the ROS/HIF-1α/G6PD axis to promote viral replication.
FOXO1 enhances G6PD expression to promote cancer cell antioxidative capacity.
Prolonged Fructose Overconsumption Activates Original Biosynthetic and Metabolic Pathways of Endogenous Purine in Rats.
Tiliroside disrupted iron homeostasis and induced ferroptosis via directly targeting calpain-2 in pancreatic cancer cells.
Prolactin receptor potentiates chemotherapy through miRNAs-induced G6PD/TKT inhibition in pancreatic cancer.
Crosstalk of non-apoptotic RCD panel in hepatocellular carcinoma reveals the prognostic and therapeutic optimization.
Effects of protoscoleces excretory-secretory products of Echinococcus granulosus on hepatocyte growth, function, and glucose metabolism.
G-protein-coupled estrogen receptor 1 promotes peritoneal metastasis of gastric cancer through nicotinamide adenine dinucleotide kinase 1-mediated redox modulation.
DUSP4 enhances therapeutic sensitivity in HER2-positive breast cancer by inhibiting the G6PD pathway and ROS metabolism by interacting with ALDOB.
Nanoparticles for inducing Gaucher disease-like damage in cancer cells.
High pyroptosis activity in pancreatic adenocarcinoma: poor prognosis and oxaliplatin resistance.
WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus.
M6A-modified circRBM33 promotes prostate cancer progression via PDHA1-mediated mitochondrial respiration regulation and presents a potential target for ARSI therapy.
ZEB1 Transcriptionally Activates PHGDH to Facilitate Carcinogenesis and Progression of HCC.
Depressed Proximal Glycolysis in Myocardium Of Human Heart Failure with Preserved Ejection Fraction.
WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus.
TP53 mutation-related senescence is an indicator of hepatocellular carcinoma patient outcomes from multiomics profiles.
Tiliroside targets TBK1 to induce ferroptosis and sensitize hepatocellular carcinoma to sorafenib.
C11orf54 promotes DNA repair via blocking CMA-mediated degradation of HIF1A.
SLC25A22 as a Key Mitochondrial Transporter Against Ferroptosis by Producing Glutathione and Monounsaturated Fatty Acids.
Proteogenomics of clear cell renal cell carcinoma response to tyrosine kinase inhibitor.
Targeting proteasomal deubiquitinases USP14 and UCHL5 with b-AP15 reduces 5-fluorouracil resistance in colorectal cancer cells.
Proteome profiling of early gestational plasma reveals novel biomarkers of congenital heart disease.
Metformin attenuates sevoflurane-induced neurogenesis damage and cognitive impairment: involvement of the Nrf2/G6PD pathway.
Role of Escin in breast cancer therapy: potential mechanism for inducing ferroptosis and synergistic antitumor activity with cisplatin.
Huangqi-Danshen decoction reshapes renal glucose metabolism profiles that delays chronic kidney disease progression.
Role of Nrf2 in 1,2-dichloropropane-induced cell proliferation and DNA damage in the mouse liver.
Hypoxia induces a glycolytic complex in intestinal epithelial cells independent of HIF-1-driven glycolytic gene expression.
Critical Role of 6-Phosphogluconate Dehydrogenase in TAp73-Mediated Cancer Cell Proliferation.
Cigarette Smoke Exposure Increases Glucose-6-phosphate Dehydrogenase, Autophagy, Fibrosis, and Senescence in Kidney Cells In Vitro and In Vivo.
Cuproptosis regulator-mediated patterns associated with immune infiltration features and construction of cuproptosis-related signatures to guide immunotherapy.
Novel Prognostic Signatures of Hepatocellular Carcinoma Based on Metabolic Pathway Phenotypes.
Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues.
G6PD-mediated increase in de novo NADP(+) biosynthesis promotes antioxidant defense and tumor metastasis.
Glucose-6-phosphate dehydrogenase exerts antistress effects independently of its enzymatic activity.
Inhibition of STAT3 reverses Taxol-resistance in ovarian cancer by down-regulating G6PD expression in vitro.
Prognostic and predictive role of a metabolic rate-limiting enzyme signature in hepatocellular carcinoma.
PIKE-A promotes glioblastoma growth by driving PPP flux through increasing G6PD expression mediated by phosphorylation of STAT3.
Elevation of Chemosensitivity of Lung Adenocarcinoma A549 Spheroid Cells by Claudin-2 Knockdown through Activation of Glucose Transport and Inhibition of Nrf2 Signal.
TSP50 promotes hepatocyte proliferation and tumour formation by activating glucose-6-phosphate dehydrogenase (G6PD).
Establishing and validating a pathway prognostic signature in pancreatic cancer based on miRNA and mRNA sets using GSVA.
Targeting G6PD reverses paclitaxel resistance in ovarian cancer by suppressing GSTP1.
4-hydroxyphenylpyruvate dioxygenase promotes lung cancer growth via pentose phosphate pathway (PPP) flux mediated by LKB1-AMPK/HDAC10/G6PD axis.
ABT737 reverses cisplatin resistance by targeting glucose metabolism of human ovarian cancer cells.
Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway.
CDC5L drives FAH expression to promote metabolic reprogramming in melanoma.
The Essential Role of H19 Contributing to Cisplatin Resistance by Regulating Glutathione Metabolism in High-Grade Serous Ovarian Cancer.
Liu W, Wang B, Kong F, Cheung C
Analytical cellular pathology (Amsterdam) 2026;2026(1):e6120748
Analytical cellular pathology (Amsterdam) 2026;2026(1):e6120748
Jiedu Quyu Ziyin prescription alleviated renal injury in MRL/lpr by inhibiting PPP-mediated oxidative stress through regulating p53/G6PD/NOX pathway.
Chang R, Luo Y, Hu C, Xu X, Chen L, Wu J, Ding X
Journal of ethnopharmacology 2026 Jan 30;355(Pt A):120307
Journal of ethnopharmacology 2026 Jan 30;355(Pt A):120307
Synergistic regulation of SLC7A11 and glucose-6-phosphate dehydrogenase in redox homeostasis governs decidualization: a mechanistic insight into adenomyosis-related infertility.
Zhang Y, Gu W, Zhao F, Zhang Y, Zhou F, Zeng B, Wang X, Lin X, Jin X, Liu N, Yang W, Zhang S, Dai Y
Journal of advanced research 2026 Feb 19;
Journal of advanced research 2026 Feb 19;
Developmental lead exposure induces neurotoxicity via glycolytic failure, glial activation, and miR-144 downregulation in male rat offspring.
Zeid SMA, Mahmoud MO, Boshra SA, Gomaa SB
Tissue & cell 2026 Aug;101:103462
Tissue & cell 2026 Aug;101:103462
Exploration of the relationship between apoptosis related characteristic genes and the prognosis of HCC.
Zhang Q, Cao Z, Cao H, Wu H, Yan S, Kan Y, Cui X, Feng Y, Liu Z
Journal of Cancer 2025;16(11):3485-3496
Journal of Cancer 2025;16(11):3485-3496
The lactylation of glucose-6-phosphate dehydrogenase promotes malignant phenotypes in cancer cell lines.
Zhang Y, Wu Y, Cheng A, Cui F, Yang Z, Guo J
Molecular biology reports 2025 Sep 3;52(1):861
Molecular biology reports 2025 Sep 3;52(1):861
Mechanistic insights into metformin's anti-hyperuricemic effect: Targeting PPP/DNPB/XOD-mediated purine pathway, purinosome assembly, and gut microbiota homostasis in rats.
Yu Q, Liao H, Tan W, Xu L, Lin G, Ai Z, Xie Q, Liu Y, Li Y, Yang X, Su Z, Ma G, Xie J, Lai Z
Chemico-biological interactions 2025 Nov 1;421:111783
Chemico-biological interactions 2025 Nov 1;421:111783
Pentose phosphate recycling driven by Gli1 contributes to chemotherapy resistance in cancer cells.
Hu Q, Jiang C, Qin Y, Li B, Wang J, Wang T, Ji S, Ye Z, Dang Q, Liu M, Yu X, Xu X
Cancer letters 2025 May 28;618:217633
Cancer letters 2025 May 28;618:217633
CDK5-triggered G6PD phosphorylation at threonine 91 facilitating redox homeostasis reveals a vulnerability in breast cancer.
Bei Y, Wang S, Wang R, Ahmad O, Jia M, Yao P, Ji J, Shen P
Acta pharmaceutica Sinica. B 2025 Mar;15(3):1608-1625
Acta pharmaceutica Sinica. B 2025 Mar;15(3):1608-1625
Chronic exposure to polyethylene terephthalate microplastics induces gut microbiota dysbiosis and disordered hepatic lipid metabolism in mice.
Lu T, Liu H, Yuan X, Li D, Zhang G, Wang Y, Xie Q, Wang X, Chi J, Wang Z, Wang S, Gao Y, Zhou L, Xu M
Ecotoxicology and environmental safety 2025 Jun 15;298:118330
Ecotoxicology and environmental safety 2025 Jun 15;298:118330
Matrix stiffness regulates glucose-6-phosphate dehydrogenase expression to mediate sorafenib resistance in hepatocellular carcinoma through the ITGB1-PI3K/AKT pathway.
Ren R, Zhang S, Peng Z, Ji X, Song H, Wang Q, Sun X, Wang H, Dong Y
Cell death & disease 2025 Jul 20;16(1):538
Cell death & disease 2025 Jul 20;16(1):538
Targeting Metabolic Adaptation of Colorectal Cancer with Vanadium-Doped Nanosystem to Enhance Chemotherapy and Immunotherapy.
Cheng Q, Chen Y, Zou D, Li Q, Shi X, Qin Q, Liu M, Wang L, Wang Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(7):e2409329
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(7):e2409329
Porcine reproductive and respiratory syndrome virus activates the pentose phosphate pathway via the ROS/HIF-1α/G6PD axis to promote viral replication.
Ma YX, Yang JM, Mei HT, Zeng L, Yang GY, Wang J, Ming SL, Chu BB
Virulence 2025 Dec;16(1):2585639
Virulence 2025 Dec;16(1):2585639
FOXO1 enhances G6PD expression to promote cancer cell antioxidative capacity.
Zhang X, Zhang J, Wei M, Zhao M, Wang X, Hui Y, Yuan D, Wang Z, Wu W, Jiang P, Wang Y, Li L
Journal of molecular cell biology 2025 Dec 29;17(5)
Journal of molecular cell biology 2025 Dec 29;17(5)
Prolonged Fructose Overconsumption Activates Original Biosynthetic and Metabolic Pathways of Endogenous Purine in Rats.
Yu Q, Tan W, Ma X, Xu L, Lin G, Cheng J, Xie Q, Liu Y, Li Y, Xian Y, Lin Z, Chen J, Su Z, Yang X, Xie J
Molecular nutrition & food research 2025 Aug;69(16):e70122
Molecular nutrition & food research 2025 Aug;69(16):e70122
Tiliroside disrupted iron homeostasis and induced ferroptosis via directly targeting calpain-2 in pancreatic cancer cells.
Xu M, Zhong W, Yang C, Liu M, Yuan X, Lu T, Li D, Zhang G, Liu H, Zeng Y, Yang X, Zhou Y, Zhou L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 May;127:155392
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 May;127:155392
Prolactin receptor potentiates chemotherapy through miRNAs-induced G6PD/TKT inhibition in pancreatic cancer.
Liao YN, Huang PQ, Pan H, Gai YZ, Zhan YF, Li SX, Nie HZ
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 May 31;38(10):e23705
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 May 31;38(10):e23705
Crosstalk of non-apoptotic RCD panel in hepatocellular carcinoma reveals the prognostic and therapeutic optimization.
Li S, Xu Y, Hu X, Chen H, Xi X, Long F, Rong Y, Wang J, Yuan C, Liang C, Wang F
iScience 2024 Jun 21;27(6):109901
iScience 2024 Jun 21;27(6):109901
Effects of protoscoleces excretory-secretory products of Echinococcus granulosus on hepatocyte growth, function, and glucose metabolism.
Luo G, Li H, Lu Q, Cao J, Lv H, Jiang Y
Acta tropica 2024 Jan;249:107066
Acta tropica 2024 Jan;249:107066
G-protein-coupled estrogen receptor 1 promotes peritoneal metastasis of gastric cancer through nicotinamide adenine dinucleotide kinase 1-mediated redox modulation.
Wu T, Ding K, Wang C, Lin G, Xie C, Chen X, Li Q, Yu F, Mao Y, Hong W, Lu L, Li S
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Feb 15;38(3):e23449
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Feb 15;38(3):e23449
DUSP4 enhances therapeutic sensitivity in HER2-positive breast cancer by inhibiting the G6PD pathway and ROS metabolism by interacting with ALDOB.
Wang X, Chi W, Ma Y, Zhang Q, Xue J, Shao ZM, Xiu B, Wu J, Chi Y
Translational oncology 2024 Aug;46:102016
Translational oncology 2024 Aug;46:102016
Nanoparticles for inducing Gaucher disease-like damage in cancer cells.
Yue C, Lu W, Fan S, Huang Z, Yang J, Dong H, Zhang X, Shang Y, Lai W, Li D, Dong T, Yuan A, Wu J, Kang L, Hu Y
Nature nanotechnology 2024 Aug;19(8):1203-1215
Nature nanotechnology 2024 Aug;19(8):1203-1215
High pyroptosis activity in pancreatic adenocarcinoma: poor prognosis and oxaliplatin resistance.
Wang G, Chen J, Dai S, Zhang J, Gao Y, Yin L, Jiang K, Miao Y, Lu Z
Apoptosis : an international journal on programmed cell death 2024 Apr;29(3-4):344-356
Apoptosis : an international journal on programmed cell death 2024 Apr;29(3-4):344-356
WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus.
Liu J, Duangjan C, Irwin RW, Curran SP
Mechanisms of ageing and development 2024 Apr;218:111914
Mechanisms of ageing and development 2024 Apr;218:111914
M6A-modified circRBM33 promotes prostate cancer progression via PDHA1-mediated mitochondrial respiration regulation and presents a potential target for ARSI therapy.
Zhong C, Long Z, Yang T, Wang S, Zhong W, Hu F, Teoh JY, Lu J, Mao X
International journal of biological sciences 2023;19(5):1543-1563
International journal of biological sciences 2023;19(5):1543-1563
ZEB1 Transcriptionally Activates PHGDH to Facilitate Carcinogenesis and Progression of HCC.
Wang H, Lin F, Xu Z, Yu S, Li G, Liao S, Zhao W, Zhang F, Wang J, Wang S, Ouyang C, Zhang C, Xia H, Wu Y, Jiang B, Li Q
Cellular and molecular gastroenterology and hepatology 2023;16(4):541-556
Cellular and molecular gastroenterology and hepatology 2023;16(4):541-556
Depressed Proximal Glycolysis in Myocardium Of Human Heart Failure with Preserved Ejection Fraction.
Koleini N, Meddeb M, Keykhaei M, Kwon S, Zhao L, Hahn V, Sharma K, Pearce EL, Kass DA
medRxiv : the preprint server for health sciences 2023 Oct 2;
medRxiv : the preprint server for health sciences 2023 Oct 2;
WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus.
Liu J, Duangjan C, Irwin RW, Curran SP
bioRxiv : the preprint server for biology 2023 Oct 11;
bioRxiv : the preprint server for biology 2023 Oct 11;
TP53 mutation-related senescence is an indicator of hepatocellular carcinoma patient outcomes from multiomics profiles.
Chen YY, Zhu ZY, Ma T, Zhang L, Chen J, Jiang JW, Lu CH, Ding YT, Guan WX, Yi N, Ren HZ
Smart medicine 2023 May;2(2):e20230005
Smart medicine 2023 May;2(2):e20230005
Tiliroside targets TBK1 to induce ferroptosis and sensitize hepatocellular carcinoma to sorafenib.
Yang C, Lu T, Liu M, Yuan X, Li D, Zhang J, Zhou L, Xu M
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Mar;111:154668
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Mar;111:154668
C11orf54 promotes DNA repair via blocking CMA-mediated degradation of HIF1A.
Tan J, Wang W, Liu X, Xu J, Che Y, Liu Y, Hu J, Hu L, Li J, Zhou Q
Communications biology 2023 Jun 5;6(1):606
Communications biology 2023 Jun 5;6(1):606
SLC25A22 as a Key Mitochondrial Transporter Against Ferroptosis by Producing Glutathione and Monounsaturated Fatty Acids.
Liu Y, Wang Y, Lin Z, Kang R, Tang D, Liu J
Antioxidants & redox signaling 2023 Jul;39(1-3):166-185
Antioxidants & redox signaling 2023 Jul;39(1-3):166-185
Proteogenomics of clear cell renal cell carcinoma response to tyrosine kinase inhibitor.
Zhang H, Bai L, Wu XQ, Tian X, Feng J, Wu X, Shi GH, Pei X, Lyu J, Yang G, Liu Y, Xu W, Anwaier A, Zhu Y, Cao DL, Xu F, Wang Y, Gan HL, Sun MH, Zhao JY, Qu Y, Ye D, Ding C
Nature communications 2023 Jul 17;14(1):4274
Nature communications 2023 Jul 17;14(1):4274
Targeting proteasomal deubiquitinases USP14 and UCHL5 with b-AP15 reduces 5-fluorouracil resistance in colorectal cancer cells.
Ding W, Wang JX, Wu JZ, Liu AC, Jiang LL, Zhang HC, Meng Y, Liu BY, Peng GJ, Lou EZ, Mao Q, Zhou H, Tang DL, Chen X, Liu JB, Shi XP
Acta pharmacologica Sinica 2023 Dec;44(12):2537-2548
Acta pharmacologica Sinica 2023 Dec;44(12):2537-2548
Proteome profiling of early gestational plasma reveals novel biomarkers of congenital heart disease.
Yin YN, Cao L, Wang J, Chen YL, Yang HO, Tan SB, Cai K, Chen ZQ, Xiang J, Yang YX, Geng HR, Zhou ZY, Shen AN, Zhou XY, Shi Y, Zhao R, Sun K, Ding C, Zhao JY
EMBO molecular medicine 2023 Dec 7;15(12):e17745
EMBO molecular medicine 2023 Dec 7;15(12):e17745
Metformin attenuates sevoflurane-induced neurogenesis damage and cognitive impairment: involvement of the Nrf2/G6PD pathway.
Fan P, Lu Y, Wei H, Wang K, Jia P, Zhang Y, Zhang Y, Wang T, Yang L, Zhao J, Zhang S, Lu H, Chen X, Liu Y, Zhang P
Metabolic brain disease 2023 Aug;38(6):2037-2053
Metabolic brain disease 2023 Aug;38(6):2037-2053
Role of Escin in breast cancer therapy: potential mechanism for inducing ferroptosis and synergistic antitumor activity with cisplatin.
Li C, He Z, Yao F, Liao S, Sun K, Sun S, Li Z, Wang Z
Apoptosis : an international journal on programmed cell death 2023 Aug;28(7-8):1154-1167
Apoptosis : an international journal on programmed cell death 2023 Aug;28(7-8):1154-1167
Huangqi-Danshen decoction reshapes renal glucose metabolism profiles that delays chronic kidney disease progression.
Huang X, Gao L, Deng R, Peng Y, Wu S, Lu J, Liu X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Aug;164:114989
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Aug;164:114989
Role of Nrf2 in 1,2-dichloropropane-induced cell proliferation and DNA damage in the mouse liver.
Kimura Y, Ekuban FA, Zong C, Sugie S, Zhang X, Itoh K, Yamamoto M, Ichihara S, Ohsako S, Ichihara G
Toxicological sciences : an official journal of the Society of Toxicology 2023 Aug 29;195(1):28-41
Toxicological sciences : an official journal of the Society of Toxicology 2023 Aug 29;195(1):28-41
Hypoxia induces a glycolytic complex in intestinal epithelial cells independent of HIF-1-driven glycolytic gene expression.
Kierans SJ, Fagundes RR, Malkov MI, Sparkes R, Dillon ET, Smolenski A, Faber KN, Taylor CT
Proceedings of the National Academy of Sciences of the United States of America 2023 Aug 29;120(35):e2208117120
Proceedings of the National Academy of Sciences of the United States of America 2023 Aug 29;120(35):e2208117120
Critical Role of 6-Phosphogluconate Dehydrogenase in TAp73-Mediated Cancer Cell Proliferation.
Qiao R, Wei M, Chen H, Zhang X, Zhang J, Gao L, Ma H, Wang Y, Li L
Molecular cancer research : MCR 2023 Aug 1;21(8):825-835
Molecular cancer research : MCR 2023 Aug 1;21(8):825-835
Cigarette Smoke Exposure Increases Glucose-6-phosphate Dehydrogenase, Autophagy, Fibrosis, and Senescence in Kidney Cells In Vitro and In Vivo.
Liu WC, Chuang HC, Chou CL, Lee YH, Chiu YJ, Wang YL, Chiu HW
Oxidative medicine and cellular longevity 2022;2022:5696686
Oxidative medicine and cellular longevity 2022;2022:5696686
Cuproptosis regulator-mediated patterns associated with immune infiltration features and construction of cuproptosis-related signatures to guide immunotherapy.
Wang G, Xiao R, Zhao S, Sun L, Guo J, Li W, Zhang Y, Bian X, Qiu W, Wang S
Frontiers in immunology 2022;13:945516
Frontiers in immunology 2022;13:945516
Novel Prognostic Signatures of Hepatocellular Carcinoma Based on Metabolic Pathway Phenotypes.
Ye T, Lin L, Cao L, Huang W, Wei S, Shan Y, Zhang Z
Frontiers in oncology 2022;12:863266
Frontiers in oncology 2022;12:863266
Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues.
Fan TW, Daneshmandi S, Cassel TA, Uddin MB, Sledziona J, Thompson PT, Lin P, Higashi RM, Lane AN
Journal of immunology (Baltimore, Md. : 1950) 2022 Nov 1;209(9):1674-1690
Journal of immunology (Baltimore, Md. : 1950) 2022 Nov 1;209(9):1674-1690
G6PD-mediated increase in de novo NADP(+) biosynthesis promotes antioxidant defense and tumor metastasis.
Zhang Y, Xu Y, Lu W, Li J, Yu S, Brown EJ, Stanger BZ, Rabinowitz JD, Yang X
Science advances 2022 Jul 22;8(29):eabo0404
Science advances 2022 Jul 22;8(29):eabo0404
Glucose-6-phosphate dehydrogenase exerts antistress effects independently of its enzymatic activity.
Jin X, Li X, Li L, Zhong B, Hong Y, Niu J, Li B
The Journal of biological chemistry 2022 Dec;298(12):102587
The Journal of biological chemistry 2022 Dec;298(12):102587
Inhibition of STAT3 reverses Taxol-resistance in ovarian cancer by down-regulating G6PD expression in vitro.
Sheng H, Feng Q, Quan Q, Sheng X, Zhang P
Biochemical and biophysical research communications 2022 Aug 30;617(Pt 2):62-68
Biochemical and biophysical research communications 2022 Aug 30;617(Pt 2):62-68
Prognostic and predictive role of a metabolic rate-limiting enzyme signature in hepatocellular carcinoma.
Wang Z, Fu Y, Xia A, Chen C, Qu J, Xu G, Zou X, Wang Q, Wang S
Cell proliferation 2021 Oct;54(10):e13117
Cell proliferation 2021 Oct;54(10):e13117
PIKE-A promotes glioblastoma growth by driving PPP flux through increasing G6PD expression mediated by phosphorylation of STAT3.
Sun M, Sheng H, Wu T, Song J, Sun H, Wang Y, Wang J, Li Z, Zhao H, Tan J, Li Y, Chen G, Huang Q, Zhang Y, Lan B, Liu S, Shan C, Zhang S
Biochemical pharmacology 2021 Oct;192:114736
Biochemical pharmacology 2021 Oct;192:114736
Elevation of Chemosensitivity of Lung Adenocarcinoma A549 Spheroid Cells by Claudin-2 Knockdown through Activation of Glucose Transport and Inhibition of Nrf2 Signal.
Ito A, Nasako H, Akizuki R, Takashina Y, Eguchi H, Matsunaga T, Yoshino Y, Endo S, Ikari A
International journal of molecular sciences 2021 Jun 19;22(12)
International journal of molecular sciences 2021 Jun 19;22(12)
TSP50 promotes hepatocyte proliferation and tumour formation by activating glucose-6-phosphate dehydrogenase (G6PD).
Zhang X, Gao F, Ai H, Wang S, Song Z, Zheng L, Wang G, Sun Y, Bao Y
Cell proliferation 2021 Apr;54(4):e13015
Cell proliferation 2021 Apr;54(4):e13015
Establishing and validating a pathway prognostic signature in pancreatic cancer based on miRNA and mRNA sets using GSVA.
Zhang J, Gu J, Guo S, Huang W, Zheng Y, Wang X, Zhang T, Zhao W, Ni B, Fan Y, Wang H
Aging 2020 Nov 10;12(22):22840-22858
Aging 2020 Nov 10;12(22):22840-22858
Targeting G6PD reverses paclitaxel resistance in ovarian cancer by suppressing GSTP1.
Feng Q, Li X, Sun W, Sun M, Li Z, Sheng H, Xie F, Zhang S, Shan C
Biochemical pharmacology 2020 Aug;178:114092
Biochemical pharmacology 2020 Aug;178:114092
4-hydroxyphenylpyruvate dioxygenase promotes lung cancer growth via pentose phosphate pathway (PPP) flux mediated by LKB1-AMPK/HDAC10/G6PD axis.
Shan C, Lu Z, Li Z, Sheng H, Fan J, Qi Q, Liu S, Zhang S
Cell death & disease 2019 Jul 8;10(7):525
Cell death & disease 2019 Jul 8;10(7):525
ABT737 reverses cisplatin resistance by targeting glucose metabolism of human ovarian cancer cells.
Xu Y, Gao W, Zhang Y, Wu S, Liu Y, Deng X, Xie L, Yang J, Yu H, Su J, Sun L
International journal of oncology 2018 Sep;53(3):1055-1068
International journal of oncology 2018 Sep;53(3):1055-1068
Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway.
Ma X, Wang L, Huang D, Li Y, Yang D, Li T, Li F, Sun L, Wei H, He K, Yu F, Zhao D, Hu L, Xing S, Liu Z, Li K, Guo J, Yang Z, Pan X, Li A, Shi Y, Wang J, Gao P, Zhang H
Nature communications 2017 Nov 15;8(1):1506
Nature communications 2017 Nov 15;8(1):1506
CDC5L drives FAH expression to promote metabolic reprogramming in melanoma.
Gu Z, Zhang H, Li Y, Shen S, Yin X, Zhang W, Cheng R, Zhang Y, Zhang X, Chen H, Huang B, Cao Y
Oncotarget 2017 Dec 26;8(69):114328-114343
Oncotarget 2017 Dec 26;8(69):114328-114343
The Essential Role of H19 Contributing to Cisplatin Resistance by Regulating Glutathione Metabolism in High-Grade Serous Ovarian Cancer.
Zheng ZG, Xu H, Suo SS, Xu XL, Ni MW, Gu LH, Chen W, Wang LY, Zhao Y, Tian B, Hua YJ
Scientific reports 2016 May 19;6:26093
Scientific reports 2016 May 19;6:26093
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- The G6PD antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human G6PD. This antibody recognizes human antigen. The G6PD antibody has been validated for the following applications: ELISA, WB analysis.