25413-1-AP

antibody from Proteintech Group

Targeting: G6PD G6PD1

Provider product page for 25413-1-AP

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [40]
Comments [0]
Validations
Western blot [1]

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Product number: 25413-1-AP - Provider product page
Provider: Proteintech Group
Product name: G6PD antibody
Antibody type: Polyclonal
Description: KD/KO validated G6PD antibody (Cat. #25413-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, WB,ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

G6PD protein structure - 25413-1-AP shown in red.

Submitted references Tiliroside disrupted iron homeostasis and induced ferroptosis via directly targeting calpain-2 in pancreatic cancer cells.

Xu M, Zhong W, Yang C, Liu M, Yuan X, Lu T, Li D, Zhang G, Liu H, Zeng Y, Yang X, Zhou Y, Zhou L
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Effects of protoscoleces excretory-secretory products of Echinococcus granulosus on hepatocyte growth, function, and glucose metabolism.

Luo G, Li H, Lu Q, Cao J, Lv H, Jiang Y
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G-protein-coupled estrogen receptor 1 promotes peritoneal metastasis of gastric cancer through nicotinamide adenine dinucleotide kinase 1-mediated redox modulation.

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High pyroptosis activity in pancreatic adenocarcinoma: poor prognosis and oxaliplatin resistance.

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Apoptosis : an international journal on programmed cell death 2024 Apr;29(3-4):344-356

WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus.

Liu J, Duangjan C, Irwin RW, Curran SP
Mechanisms of ageing and development 2024 Apr;218:111914

M6A-modified circRBM33 promotes prostate cancer progression via PDHA1-mediated mitochondrial respiration regulation and presents a potential target for ARSI therapy.

Zhong C, Long Z, Yang T, Wang S, Zhong W, Hu F, Teoh JY, Lu J, Mao X
International journal of biological sciences 2023;19(5):1543-1563

ZEB1 Transcriptionally Activates PHGDH to Facilitate Carcinogenesis and Progression of HCC.

Wang H, Lin F, Xu Z, Yu S, Li G, Liao S, Zhao W, Zhang F, Wang J, Wang S, Ouyang C, Zhang C, Xia H, Wu Y, Jiang B, Li Q
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medRxiv : the preprint server for health sciences 2023 Oct 2;

WDR23 mediates NRF2 proteostasis and cytoprotective capacity in the hippocampus.

Liu J, Duangjan C, Irwin RW, Curran SP
bioRxiv : the preprint server for biology 2023 Oct 11;

Tiliroside targets TBK1 to induce ferroptosis and sensitize hepatocellular carcinoma to sorafenib.

Yang C, Lu T, Liu M, Yuan X, Li D, Zhang J, Zhou L, Xu M
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Mar;111:154668

C11orf54 promotes DNA repair via blocking CMA-mediated degradation of HIF1A.

Tan J, Wang W, Liu X, Xu J, Che Y, Liu Y, Hu J, Hu L, Li J, Zhou Q
Communications biology 2023 Jun 5;6(1):606

SLC25A22 as a Key Mitochondrial Transporter Against Ferroptosis by Producing Glutathione and Monounsaturated Fatty Acids.

Liu Y, Wang Y, Lin Z, Kang R, Tang D, Liu J
Antioxidants & redox signaling 2023 Jul;39(1-3):166-185

Proteogenomics of clear cell renal cell carcinoma response to tyrosine kinase inhibitor.

Zhang H, Bai L, Wu XQ, Tian X, Feng J, Wu X, Shi GH, Pei X, Lyu J, Yang G, Liu Y, Xu W, Anwaier A, Zhu Y, Cao DL, Xu F, Wang Y, Gan HL, Sun MH, Zhao JY, Qu Y, Ye D, Ding C
Nature communications 2023 Jul 17;14(1):4274

Targeting proteasomal deubiquitinases USP14 and UCHL5 with b-AP15 reduces 5-fluorouracil resistance in colorectal cancer cells.

Ding W, Wang JX, Wu JZ, Liu AC, Jiang LL, Zhang HC, Meng Y, Liu BY, Peng GJ, Lou EZ, Mao Q, Zhou H, Tang DL, Chen X, Liu JB, Shi XP
Acta pharmacologica Sinica 2023 Dec;44(12):2537-2548

Proteome profiling of early gestational plasma reveals novel biomarkers of congenital heart disease.

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EMBO molecular medicine 2023 Dec 7;15(12):e17745

Metformin attenuates sevoflurane-induced neurogenesis damage and cognitive impairment: involvement of the Nrf2/G6PD pathway.

Fan P, Lu Y, Wei H, Wang K, Jia P, Zhang Y, Zhang Y, Wang T, Yang L, Zhao J, Zhang S, Lu H, Chen X, Liu Y, Zhang P
Metabolic brain disease 2023 Aug;38(6):2037-2053

Role of Escin in breast cancer therapy: potential mechanism for inducing ferroptosis and synergistic antitumor activity with cisplatin.

Li C, He Z, Yao F, Liao S, Sun K, Sun S, Li Z, Wang Z
Apoptosis : an international journal on programmed cell death 2023 Aug;28(7-8):1154-1167

Huangqi-Danshen decoction reshapes renal glucose metabolism profiles that delays chronic kidney disease progression.

Huang X, Gao L, Deng R, Peng Y, Wu S, Lu J, Liu X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Aug;164:114989

Role of Nrf2 in 1,2-dichloropropane-induced cell proliferation and DNA damage in the mouse liver.

Kimura Y, Ekuban FA, Zong C, Sugie S, Zhang X, Itoh K, Yamamoto M, Ichihara S, Ohsako S, Ichihara G
Toxicological sciences : an official journal of the Society of Toxicology 2023 Aug 29;195(1):28-41

Hypoxia induces a glycolytic complex in intestinal epithelial cells independent of HIF-1-driven glycolytic gene expression.

Kierans SJ, Fagundes RR, Malkov MI, Sparkes R, Dillon ET, Smolenski A, Faber KN, Taylor CT
Proceedings of the National Academy of Sciences of the United States of America 2023 Aug 29;120(35):e2208117120

Critical Role of 6-Phosphogluconate Dehydrogenase in TAp73-Mediated Cancer Cell Proliferation.

Qiao R, Wei M, Chen H, Zhang X, Zhang J, Gao L, Ma H, Wang Y, Li L
Molecular cancer research : MCR 2023 Aug 1;21(8):825-835

Cigarette Smoke Exposure Increases Glucose-6-phosphate Dehydrogenase, Autophagy, Fibrosis, and Senescence in Kidney Cells In Vitro and In Vivo.

Liu WC, Chuang HC, Chou CL, Lee YH, Chiu YJ, Wang YL, Chiu HW
Oxidative medicine and cellular longevity 2022;2022:5696686

Cuproptosis regulator-mediated patterns associated with immune inﬁltration features and construction of cuproptosis-related signatures to guide immunotherapy.

Wang G, Xiao R, Zhao S, Sun L, Guo J, Li W, Zhang Y, Bian X, Qiu W, Wang S
Frontiers in immunology 2022;13:945516

Novel Prognostic Signatures of Hepatocellular Carcinoma Based on Metabolic Pathway Phenotypes.

Ye T, Lin L, Cao L, Huang W, Wei S, Shan Y, Zhang Z
Frontiers in oncology 2022;12:863266

Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues.

Fan TW, Daneshmandi S, Cassel TA, Uddin MB, Sledziona J, Thompson PT, Lin P, Higashi RM, Lane AN
Journal of immunology (Baltimore, Md. : 1950) 2022 Nov 1;209(9):1674-1690

G6PD-mediated increase in de novo NADP(+) biosynthesis promotes antioxidant defense and tumor metastasis.

Zhang Y, Xu Y, Lu W, Li J, Yu S, Brown EJ, Stanger BZ, Rabinowitz JD, Yang X
Science advances 2022 Jul 22;8(29):eabo0404

Glucose-6-phosphate dehydrogenase exerts antistress effects independently of its enzymatic activity.

Jin X, Li X, Li L, Zhong B, Hong Y, Niu J, Li B
The Journal of biological chemistry 2022 Dec;298(12):102587

Inhibition of STAT3 reverses Taxol-resistance in ovarian cancer by down-regulating G6PD expression in vitro.

Sheng H, Feng Q, Quan Q, Sheng X, Zhang P
Biochemical and biophysical research communications 2022 Aug 30;617(Pt 2):62-68

Prognostic and predictive role of a metabolic rate-limiting enzyme signature in hepatocellular carcinoma.

Wang Z, Fu Y, Xia A, Chen C, Qu J, Xu G, Zou X, Wang Q, Wang S
Cell proliferation 2021 Oct;54(10):e13117

PIKE-A promotes glioblastoma growth by driving PPP flux through increasing G6PD expression mediated by phosphorylation of STAT3.

Sun M, Sheng H, Wu T, Song J, Sun H, Wang Y, Wang J, Li Z, Zhao H, Tan J, Li Y, Chen G, Huang Q, Zhang Y, Lan B, Liu S, Shan C, Zhang S
Biochemical pharmacology 2021 Oct;192:114736

Elevation of Chemosensitivity of Lung Adenocarcinoma A549 Spheroid Cells by Claudin-2 Knockdown through Activation of Glucose Transport and Inhibition of Nrf2 Signal.

Ito A, Nasako H, Akizuki R, Takashina Y, Eguchi H, Matsunaga T, Yoshino Y, Endo S, Ikari A
International journal of molecular sciences 2021 Jun 19;22(12)

TSP50 promotes hepatocyte proliferation and tumour formation by activating glucose-6-phosphate dehydrogenase (G6PD).

Zhang X, Gao F, Ai H, Wang S, Song Z, Zheng L, Wang G, Sun Y, Bao Y
Cell proliferation 2021 Apr;54(4):e13015

Establishing and validating a pathway prognostic signature in pancreatic cancer based on miRNA and mRNA sets using GSVA.

Zhang J, Gu J, Guo S, Huang W, Zheng Y, Wang X, Zhang T, Zhao W, Ni B, Fan Y, Wang H
Aging 2020 Nov 10;12(22):22840-22858

Targeting G6PD reverses paclitaxel resistance in ovarian cancer by suppressing GSTP1.

Feng Q, Li X, Sun W, Sun M, Li Z, Sheng H, Xie F, Zhang S, Shan C
Biochemical pharmacology 2020 Aug;178:114092

4-hydroxyphenylpyruvate dioxygenase promotes lung cancer growth via pentose phosphate pathway (PPP) flux mediated by LKB1-AMPK/HDAC10/G6PD axis.

Shan C, Lu Z, Li Z, Sheng H, Fan J, Qi Q, Liu S, Zhang S
Cell death & disease 2019 Jul 8;10(7):525

ABT737 reverses cisplatin resistance by targeting glucose metabolism of human ovarian cancer cells.

Xu Y, Gao W, Zhang Y, Wu S, Liu Y, Deng X, Xie L, Yang J, Yu H, Su J, Sun L
International journal of oncology 2018 Sep;53(3):1055-1068

Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway.

Ma X, Wang L, Huang D, Li Y, Yang D, Li T, Li F, Sun L, Wei H, He K, Yu F, Zhao D, Hu L, Xing S, Liu Z, Li K, Guo J, Yang Z, Pan X, Li A, Shi Y, Wang J, Gao P, Zhang H
Nature communications 2017 Nov 15;8(1):1506

CDC5L drives FAH expression to promote metabolic reprogramming in melanoma.

Gu Z, Zhang H, Li Y, Shen S, Yin X, Zhang W, Cheng R, Zhang Y, Zhang X, Chen H, Huang B, Cao Y
Oncotarget 2017 Dec 26;8(69):114328-114343

The Essential Role of H19 Contributing to Cisplatin Resistance by Regulating Glutathione Metabolism in High-Grade Serous Ovarian Cancer.

Zheng ZG, Xu H, Suo SS, Xu XL, Ni MW, Gu LH, Chen W, Wang LY, Zhao Y, Tian B, Hua YJ
Scientific reports 2016 May 19;6:26093

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The G6PD antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human G6PD. This antibody recognizes human antigen. The G6PD antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 25413-1-AP.pdf

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