66373-1-Ig

antibody from Proteintech Group

Targeting: G6PD G6PD1

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

66373-1-Ig

Provider

Proteintech Group

Product name

G6PD antibody

Antibody type

Monoclonal

Description

KD/KO validated G6PD antibody (Cat. #66373-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

2A7B12

Vial size

20ul, 150ul

References

Submitted references

Identification of the disulfidptosis-related gene G6PD as a potential biomarker and therapeutic target in pancreatic ductal adenocarcinoma by integrative bioinformatics analysis and experimental validation.

Su S, Wu B, Han T, Wang X, Lou F, Mei Z, Guo L
Discover oncology 2026 Mar 4;17(1)

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A demethylation-driven gene signature predicts prognosis and therapeutic vulnerability in hepatocellular carcinoma.

Wang Z, Shi L, Li Y, Liu S, Shi W
Scientific reports 2026 Feb 26;16(1)

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G6PD facilitates axon regeneration via clathrin-mediated endocytosis.

Jiang C, Liu X, Li H, Lu Y, Cao Q, Yu B, Mao S
The Journal of biological chemistry 2026 Apr;302(4):111345

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Integrative metabolomics and lipidomics reveal Jian-Pi-Yi-Shen formula improves adenine-induced CKD rats by regulating intrarenal glycolipid metabolism.

Liu X, Li H, Xu Y, Peng Y, Wu S, Ye X, Yang Y, Lu J
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2026 Apr 1;1273:124957

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CELF1 promotes aerobic glycolysis and an aggressive phenotype in ER-positive breast cancer via GLUT1 regulation.

Li J, Wang N, Bi J, Guo M, Xu B, Huang G
Frontiers in genetics 2025;16:1687066

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The lactylation of glucose-6-phosphate dehydrogenase promotes malignant phenotypes in cancer cell lines.

Zhang Y, Wu Y, Cheng A, Cui F, Yang Z, Guo J
Molecular biology reports 2025 Sep 3;52(1):861

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PKM2 alleviates mitochondrial oxidative stress and neuronal apoptosis through metabolic and non-metabolic pathways to protect SOD1(G93A) mice.

Zhang Z, Guo X, Liu Y, Ke P, Meng Y, Gu J, Hu L, Yuan Z, Duan R, Luo J, Xiao F
Free radical biology & medicine 2025 Oct;238:1-16

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RIOK1 phase separation restricts PTEN translation via stress granules activating tumor growth in hepatocellular carcinoma.

Meng F, Li H, Huang Y, Wang C, Liu Y, Zhang C, Chen D, Zeng T, Zhang S, Li Y, Zhang B, Lang C, Xia J, Xiong W, Pan S, Sun X, Thorne RF, Liu Y, Wang J, Zhang S, Song R, Wang J, Liu L
Nature cancer 2025 Jul;6(7):1223-1241

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G6PD deficiency triggers dopamine loss and the initiation of Parkinson's disease pathogenesis.

Stykel MG, Siripala SV, Soubeyrand E, Coackley CL, Lu P, Camargo S, Thevasenan S, Figueroa GB, So RWL, Stuart E, Panchal R, Akrioti EK, Joseph JT, Haji-Ghassemi O, Taoufik E, Akhtar TA, Watts JC, Ryan SD
Cell reports 2025 Jan 28;44(1):115178

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G6PD protects against cerebral ischemia-reperfusion injury by inhibiting excessive mitophagy.

Li Y, Gao Y, Yu G, Ye Y, Zhu H, Wang J, Li Y, Chen L, Gu L
Life sciences 2025 Feb 1;362:123367

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Excessive SOX8 reprograms energy and iron metabolism to prime hepatocellular carcinoma for ferroptosis.

Yang X, Gu C, Cai J, Li F, He X, Luo L, Xiao W, Hu B, Hu J, Qian H, Ren S, Zhang L, Zhu X, Yang L, Yang J, Yang Z, Zheng Y, Huang X, Wang Z
Redox biology 2024 Feb;69:103002

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Inhibiting G6PD by quercetin promotes degradation of EGFR T790M mutation.

Ge Z, Xu M, Ge Y, Huang G, Chen D, Ye X, Xiao Y, Zhu H, Yin R, Shen H, Ma G, Qi L, Wei G, Li D, Wei S, Zhu M, Ma H, Shi Z, Wang X, Ge X, Qian X
Cell reports 2023 Nov 28;42(11):113417

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Xiaojianzhong decoction attenuates aspirin-induced gastric mucosal injury via the PI3K/AKT/mTOR/ULK1 and AMPK/ULK1 pathways.

Chen T, Bao S, Chen J, Zhang J, Wei H, Hu X, Liang Y, Li J, Yan S
Pharmaceutical biology 2023 Dec;61(1):1234-1248

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Cyclosporine A alleviates colitis by inhibiting the formation of neutrophil extracellular traps via the regulating pentose phosphate pathway.

Xu C, Ye Z, Jiang W, Wang S, Zhang H
Molecular medicine (Cambridge, Mass.) 2023 Dec 13;29(1):169

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G6PD Deficiency Is Crucial for Insulin Signaling Activation in Skeletal Muscle.

Jiang A, Guo H, Jiang X, Tao J, Wu W, Liu H
International journal of molecular sciences 2022 Jul 4;23(13)

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The E3 ubiquitin ligase TRIM31 is involved in cerebral ischemic injury by promoting degradation of TIGAR.

Zeng S, Zhao Z, Zheng S, Wu M, Song X, Li Y, Zheng Y, Liu B, Chen L, Gao C, Liu H
Redox biology 2021 Sep;45:102058

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Mechanistic Analysis of an Extracellular Signal-Regulated Kinase 2-Interacting Compound that Inhibits Mutant BRAF-Expressing Melanoma Cells by Inducing Oxidative Stress.

Martinez R 3rd, Huang W, Samadani R, Mackowiak B, Centola G, Chen L, Conlon IL, Hom K, Kane MA, Fletcher S, Shapiro P
The Journal of pharmacology and experimental therapeutics 2021 Jan;376(1):84-97

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Upregulation of Antioxidant Capacity and Nucleotide Precursor Availability Suffices for Oncogenic Transformation.

Zhang Y, Xu Y, Lu W, Ghergurovich JM, Guo L, Blair IA, Rabinowitz JD, Yang X
Cell metabolism 2021 Jan 5;33(1):94-109.e8

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Progesterone Regulates Glucose Metabolism Through Glucose Transporter 1 to Promote Endometrial Receptivity.

Zhang H, Qi J, Wang Y, Sun J, Li Z, Sui L, Fan J, Liu C, Shang Y, Kong L, Kong Y
Frontiers in physiology 2020;11:543148

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SIRT5 deficiency enhances the proliferative and therapeutic capacities of adipose-derived mesenchymal stem cells via metabolic switching.

Ou T, Yang W, Li W, Lu Y, Dong Z, Zhu H, Sun X, Dong Z, Weng X, Chang S, Li H, Li Y, Qiu Z, Hu K, Sun A, Ge J
Clinical and translational medicine 2020 Sep;10(5):e172

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High glucose-induced ubiquitination of G6PD leads to the injury of podocytes.

Wang M, Hu J, Yan L, Yang Y, He M, Wu M, Li Q, Gong W, Yang Y, Wang Y, Handy DE, Lu B, Hao C, Wang Q, Li Y, Hu R, Stanton RC, Zhang Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 May;33(5):6296-6310