Antibody data
- Antibody Data
- Antigen structure
- References [0]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- 10-10013-25 - Provider product page
- Provider
- ABEOMICS Inc.
- Product name
- Anti-c-MYC Antibody
- Antibody type
- Monoclonal
- Description
- c-Myc proto-oncogene encodes nuclear DNA-binding phosphoproteins that are involved in the regulation of gene expression and DNA replication during cell growth and differentiation. Myc encodes a protein of 65 kDa which is expressed in almost all normal and transformed cells. The Myc protein activates transcription as part of a heteromeric complex with Max. Myc protein represses the expression of Ferritin-H, which sequesters intracellular iron, and stimulates the expression of IRP2 (Iron Regulatory Protein-2), which increases the intracellular iron pool. Myc induces transcription of the E2F1, E2F2 and E2F3 genes. Myc-induced S phase and apoptosis requires distinct E2F activities. The induction of specific E2F activities is an essential component in the Myc pathways that control cell proliferation and cell fate decisions.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Antigen sequence
A synthetic peptide corresponding t
o amino acids 408-432 (AEEQKLISEEDL
LRKRREQLKHKLE) of human c-Myc was u
sed as the immunogen for this antib
ody.- Isotype
- IgG
- Antibody clone number
- 9 E 10
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing
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Supportive validation
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- ABEOMICS Inc. (provider)
- Main image
- Experimental details
- Western blot analysis of c-Myc. Anti-c-Myc antibody (Clone:9 E 10) was tested at 2 µg/ml on HEK293 lysate.
- Protocol
- Protocol