Antibody data
- Antibody Data
- Antigen structure
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- Product number
- APR05329G - Provider product page
- Provider
- Leading Biology
- Product name
- Phospho-CCND3(T283) Antibody
- Antibody type
- Polyclonal
- Description
- The protein encoded by this gene belongs to the highlyconserved cyclin family, whose members are characterized by adramatic periodicity in protein abundance through the cell cycle.Cyclins function as regulators of CDK kinases. Different cyclinsexhibit distinct expression and degradation patterns whichcontribute to the temporal coordination of each mitotic event. Thiscyclin forms a complex with and functions as a regulatory subunitof CDK4 or CDK6, whose activtiy is required for cell cycle G1/Stransition. This protein has been shown to interact with and beinvolved in the phosphorylation of tumor suppressor protein Rb. TheCDK4 activity associated with this cyclin was reported to benecessary for cell cycle progression through G2 phase into mitosisafter UV radiation. Several transcript variants encoding differentisoforms have been found for this gene.
- Reactivity
- Human
- Host
- Rabbit
- Storage
- Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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