Antibody data

Product number
Ab098455 - Provider product page
Provider
Aladdin Scientific
Product name
Cyclin D3/CCND3 Antibody
Antibody type
Polyclonal
Description
Rabbit anti Human Cyclin D3/CCND3 Antibody, Polyclonal, could be used for WB and so on.Application:WB: : 0.01-3µg/mLProtein FunctionRegulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
Reactivity
Human, Mouse
Host
Rabbit
Conjugate
Unconjugated
Antigen sequence
AA 1-292
Vial size
100μl,10μl,1ml,20μl,50μl
Concentration
Lot by Lot
Storage
Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.
CCND3 protein structure - Ab098455 shown in red.