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- Antibody Data
- Antigen structure
- References [961]
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- Product number
- 15613-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15613-1-AP, RRID:AB_2105691
- Product name
- Fibronectin antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Fibronectin antibody (Cat. #15613-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references PTPN1 Regulation via YBX1-PTBP1 Interaction Promotes Fibroblast Activation and Fibrotic Remodeling in the Lung.
TAPI-1 Combined With Silicone Stents Alleviated Severe Traumatic Tracheal Stenosis via the ADAM17/TGF-β1 Pathway.
Yifei Decoction Regulates the NGF/TRKA/PI3K/AKT Signaling Axis to Inhibit the Epithelial-Mesenchymal Transformation and Proliferation of Pulmonary Epithelial Cells in Bleomycin-Induced Pulmonary Fibrogenesis.
Stem cell therapy targets THBS1 to reverse endometrial fibrosis.
Propofol Exerted an Anti-Asthmatic Effect by Attenuating Extracellular Matrix Deposition and Viability of Airway Smooth Muscle Cells.
Astragalus membranaceus Polysaccharides Attenuate Osteoarthritis in Human Primary Chondrocytes and in Animal Model: Mechanism Study Using RNA-Seq and Network Pharmacology.
Treatment with anti-Hsp90 antibody mitigates fibronectin-related cardiac fibrosis induced by pressure overload in mice.
Effect of TGFβ-ITGB6 feedback loop on liver metastasis in SMAD4 wild-type pancreatic cancer.
Study on the anti-pulmonary fibrosis mechanism of Renshen Pingfei formula by inhibiting M2 macrophage polarization and regulating TGF - β/SMAD signaling pathway.
Sodium hyaluronate based multifunctional hydrogels delivering SiRNA for sustained silencing of SMAD3: A novel strategy to treat intrauterine adhesions.
N-acetylglucosamine ameliorates the transition from acute kidney injury to chronic kidney disease by reducing the accumulation of lipid droplets.
Single-Cell Multimodal Profiling Highlights Persistent Aortic Smooth Muscle Cell Changes in Diabetic Mice Despite Glycemic Control.
Safeguarding VSMC Contractile Phenotype With In Situ circRNA-mediated Endothelial Olaratumab Engineering to Prevent Vascular Graft Stenosis.
Biomimetic epiphysis inspired by natural developmental mechanisms promote the repair of large-scale epiphyseal defects.
Dahuang Zhechong pill alleviates pulmonary fibrosis by inhibiting apoptosis and epithelial-mesenchymal transition of type II alveolar epithelial cells in vitro and in vivo.
An integrated network pharmacology and proteomics approach reveals the anti-fibrotic effect of Fushen Granule on peritoneal fibrosis.
Methylated circPTK2 as a driver of fibroblast activation in pulmonary fibrosis.
AG1295 Attenuates High-Glucose-Induced Proliferation, Migration, Phenotype Transition, and Interleukin-6 Expression in Human Corneal Stromal Fibroblasts.
Renal Tubule-Specific Deletion of Nephrocystin 3 (Nphp3) Causes Infantile Nephronophthisis-like Phenotypes in Mice.
cGAS-STING signaling pathway promotes ischemic kidney injury by regulating HK3-mediated lipid accumulation.
Exosomal miRNA let-7i-5p alleviates asthma triggered by RSV-induced exosomes by regulating dendritic cell autophagy via the MITF/DAP1/P70S6K pathway.
Comparing Effects of Short- and Long-Term Exposure of Cigarette Smoke Extract on Human Vocal Fold Fibroblasts.
CSB6B attenuates renal inflammation and fibrosis by inhibiting the activation of NLRP3 inflammasome through the NLRP3/Caspase-1/GSDMD/IL-1β signaling pathway.
Unveiling Novel Biomarkers: Ferroptosis and m1A in the Progression of Nanographene-Induced Lung Fibrosis.
Yujie recipe attenuates bleomycin-induced pulmonary fibrosis via suppressing NF-κB/NLRP3 signaling in a Nrf2-dependent manner.
Design of RGD-functionalized GSH-responsive pegylated polymeric protacs for selective BRD4 degradation and EndMT-driven cardiac fibrosis inhibition.
Bacteriocin-transport-inspired oral peptide-probiotic delivery ameliorates IBD complications via autophagy and gut homeostasis.
Neuroprotective Effects of Desert Milk Exosomes in LPS-Induced Cognitive Decline: Role of Microglial M2 Polarization and AMPK Signaling.
Discovery of XRF-1021, a 2,4-disubstituted-5-fluoropyrimidine derivative as a homeodomain-interacting protein kinase 2 inhibitor for the treatment of chronic kidney disease.
A fibroblast-like endothelial cell state promotes atherosclerosis via C/EBPβ-activated TGF-β signaling.
Intestinal metabolite TMAO promotes CKD progression by stimulating macrophage M2 polarization through histone H4 lysine 12 lactylation.
TREM2 Facilitates Myelin Debris Clearance but Exacerbates Chronic Inflammation and Fibrosis After Spinal Cord Injury.
Silencing the fibronectin gene (FN1) improves NaCl-induced cardiac fibrosis via ferritinophagy-mediated ferroptosis in a nuclear receptor coactivator 4 (NCOA4)-dependent manner.
Mettl3-Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS.
Ubiquitination degradation of GATA4 by CUL4B promotes ovarian cancer metastasis by inducing lysosomal acidification.
aFGF rescues high glucose-induced senescent fibroblasts and improves diabetic wound healing by regulating SIRT1/STAT3 pathway.
Uncovering a Glaucoma-Linked Lysophosphatidic Acid-MAPK/AP-1 Fibrosis Axis in Human Trabecular Meshwork Cells and Its Modulation by Diospyros kaki Leaf Extract.
Exosomal microRNAs of tuberculous pleural effusion orchestrating TGF-β signaling mediate pleural fibrosis.
Targeted inhibition of RGS19 alleviates renal fibrosis by restoring autophagy and modulating immune cell infiltration.
IGFBP-5/TGF-β1 mediated crosstalk between endothelial and tubular epithelial cells promotes interstitial fibrosis.
Integrative analysis of single-cell RNA sequencing, bulk RNA sequencing, and proteomic data identified NOTCH3 as a hub gene contributing to human intervertebral disc fibrosis.
Ultraviolet-induced Glycyrrhiza polysaccharide hydrogels with different mechanical strength for wound management.
Cadmium exposure induces renal fibrosis by inhibiting hsa_circ_0075684/miR-363-3p/KLF4 signaling pathway.
Integrated network pharmacology and bioinformatics analysis reveals MME as key target of Notoginsenoside R1 in diabetic nephropathy.
Fibrotic scar formation after cerebral ischemic stroke: Targeting the Sonic hedgehog signaling pathway for scar reduction.
A translational systems medicine approach to devising nanotherapeutics for targeted intervention of MASLD.
Three-dimensional cell culture in vitro could better recapitulate the biological behavior of cells in vivo.
Flexible Bioactive Glass-Fiber-Reinforced Recombinant Collagen Sponge for Versatile Hemostasis, Antibacterial Protection, and Functional Skin Regeneration.
Extracellular vesicles derived from senescent hepatocytes drive pan-cancer metastasis in aging.
Targeting SAT1 alleviates high glucose-induced tubular ferroptosis and fibrosis: implications for diabetic kidney disease.
DOT1L Drives Endothelial-to-Mesenchymal Transition and Fibrotic Vascular Remodeling via H3K79 Methylation.
Knockdown of METTL3 ameliorated myofibroblast activities in oral submucous fibrosis through upregulating DKK3.
The mechanism of fibronectin 1 promoting papillary thyroid cancer progression by regulating anoikis resistance.
Non-steroidal mineralocorticoid receptor antagonist finerenone ameliorates diabetic nephropathy via suppressing SLC7A11-mediated ferroptosis.
BRD2 is a transcriptional coactivator of Smad3 in mediating TGF-β tumor suppressive responses.
A novel gene edited rat model of cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL).
SESN2 inhibits tubular exosome secretion and diabetic kidney disease progression by restoring the autophagy‒lysosome pathway.
Cancer-associated Fibroblast-like Cells Promote Osteosarcoma Metastasis by Upregulation of Phosphoserine Aminotransferase 1 and Activation of the mTOR/S6K Pathway.
Inhibition of Mettl3 alleviates low-dose cisplatin-induced renal fibrosis and enhances the chemotherapeutic efficacy in mouse models of cancer.
Umbilical Cord Mesenchymal Stem Cells Attenuate Podocyte Injury in Diabetic Nephropathy Rats by Inhibiting Angpltl4/Integrin β3 in the Glomerulus.
Targeting interferon-stimulated gene of 20 kDa protein (Isg20) inhibits ribosome biogenesis to ameliorate the progression of renal fibrosis.
FAK-Induced Time Dependent Cell Response Profiling: Prediction, Identification, and Analysis of Anti-Tumor Immune Natural Products.
Cordycepin Ameliorates Renal Interstitial Fibrosis by Inhibiting Drp1-Mediated Mitochondrial Fission.
Single-Cell RNA-Seq Uncovers Cellular Heterogeneity from Deep Fascia in Necrotizing Fasciitis Patients.
SIRT1 Enhancement is Required for the Induction of Anti-Inflammatory Effect of Micheliolide in Carbon Tetrachloride Induced Liver Fibrosis in Mice.
Identification of Novel Gene Signature Predicting Lymph Node Metastasis in Papillary Thyroid Cancer via Bioinformatics Analysis and in vitro Validation.
NETs drive myocardial fibrosis in hypertension via an NF-κB/ferroptosis axis.
Isorhamnetin attenuates renal interstitial fibrosis by targeting TWEAK/Fn14-mediated epithelial-mesenchymal transition.
Identification of regulatory cell death-related genes during MASH progression using bioinformatics analysis and machine learning strategies.
Yiqi Qingre Gao alleviates renal fibrosis in UUO mice via PI3K/AKT pathway.
Xanthohumol ameliorates diabetic kidney disease through suppression of renal fibrosis by regulating SNHG10/miR-378b.
Dimethyl malonate alleviates obstructive nephropathy by enhancing renal metabolism and inhibiting kidney oxidative stress and inflammation.
CAV1 promotes epithelial-to-mesenchymal transition (EMT) and chronic renal allograft interstitial fibrosis by activating the ferroptosis pathway.
Genome-wide CRISPR/Cas9 screening identifies key profibrotic regulators of TGF-β1-induced epithelial-mesenchymal transformation and pulmonary fibrosis.
The Paeonol of Total Glucosides of White Peony Regulates the Differentiation of CD4+Treg Cells through the EP300/Foxp3 Axis to Relieve Pulmonary Fibrosis in Mice.
Prolyl hydroxylase-2 (EGLN1) mediates TGF-β1 pathway regulated epithelial-mesenchymal transition in yak kidneys.
Integrin αvβ6 mediates the effects of age-related decreases in matrix stiffness on Tenon's fibroblast activation and bleb scarring in glaucoma.
Multi-omics analysis of the active components and mechanisms of Baojin Chenfei formula in silica-induced murine silicosis.
PINK1 deficiency alleviates bleomycin-induced pulmonary fibrosis in mice.
Exploring the mechanism of action of trastuzumab-induced cardiomyocyte atrophy based on the FN1/PI3K/AKT-mediated mTOR-independent signaling pathway.
Yishen Qufeng formula mediates ferroptosis to improve renal fibrosis in unilateral ureteral obstruction rats.
4EBP1 phosphorylation mediates TGF-β1-induced hepatic fibrosis and upregulates HIF-1α expression.
Targeting USP21 to inhibit abdominal aortic aneurysm progression by suppressing the phenotypic transition of vascular smooth muscle cells.
Decabromodiphenyl ethane induces intrauterine growth restriction by suppressing placental angiogenesis via TWIST2/NAT10-mediated ac4C-dependent TGF-β1 mRNA stabilization.
Podoplanin-TGF-β1 Autocrine Loop: Pivotal Regulator of Islet Stellate Cell Activation via Cell Deformation, Orchestrating Islet Fibrosis in Diabetes.
Lithospermic acid improves diabetic kidney fibrosis by regulating Piezo1/TGF-β1/Smad signaling pathway.
Magnesium ions attenuate tendon graft fibrosis during its ligamentization after ACL reconstruction through modulation of fibroblast to myofibroblast trans-differentiation by promoting PGE2 secretion.
Bioengineered platelet nanoplatform enables renal-targeted dexamethasone delivery for chronic nephritis therapy with dual anti-inflammatory/anti-fibrotic effects and minimized systemic toxicity.
CCP1 Inhibits Pulmonary Fibrosis by Suppressing Fibrotic Progression Through the EIF4B/PI3K/AKT Pathways.
Isoimperatorin Reduces Synovial Inflammation and Fibrosis in Knee Osteoarthritis via the cAMP Signalling Pathway.
Triamcinolone Acetonide (TCA)-Loaded Biodegradable Microspheres Improve Therapeutic Outcomes in Thyroid-Associated Ophthalmopathy (TAO) by Reducing Fibrosis and Adipogenesis.
CAMKK2 restored mitochondrial dynamics homeostasis to alleviate pulmonary fibrosis via AMPK/PGC-1α signaling pathway in lung fibroblasts.
Functional metabolomics revealed pyroglutamic acid may play a key role in idiopathic pulmonary fibrosis.
Interplay of axon regeneration genes and immune infiltration in spinal cord injury.
Faecalibacterium prausnitzii alleviates Graves' orbitopathy by modulating short-chain fatty acid (SCFA) metabolism and inhibiting orbital fibrosis and adipogenesis.
Lysyl oxidase-like 2 inhibition alleviates subretinal fibrosis in neovascular age-related macular degeneration model.
Aristolochic acid I promotes renal tubulointerstitial fibrosis by activating the mannan-binding lectin serine protease 1-complement system.
GATA1 promotes TGF-β1-induced epithelial-mesenchymal transition by regulating GSDMB in human bronchial epithelial cells.
A novel off-liver sinusoidal progenitor cells in supporting transplantable bioliver engineering.
Quercetin ameliorates renal injury by promoting UCP1-mediated alleviation of lipid accumulation in diabetic kidney disease.
MicroRNA-93-5p alleviates uric acid-induced fibrosis in renal tubular epithelial cells by regulating the SMAD5/Id2 signaling pathway.
Integrated analysis of single-cell RNA-seq and ATAC-seq in lens epithelial cells: Unveiling the role of ATF6 as a key transcription factor.
Role of TRPV6-Mediated Calcium Signaling in High-Glucose-Inhibited Keratinocyte Migration.
Artificial Intelligence-Driven Discovery of Pyrazolo[1,5-a]pyrimidine Derivatives as Novel Phosphodiesterase 4 Inhibitors for Treating Idiopathic Pulmonary Fibrosis.
TRIM36 inhibits lung fibroblast activation and pulmonary fibrosis through the degradation of phospho-AKT1.
HMGA1 drives EMT in obliterative bronchiolitis through epigenetic regulation of chromatin accessibility in pulmonary epithelial cells.
Engineering Three-Dimensional Cellular Organization by Regulating Bound Water-Mediated Cell-Substrate Interactions for Disease Modeling.
TGF-β2 increases eHSP90α secretion via upregulating secretory autophagy pathway.
Poricoic Acid A attenuated TGF-β1-induced epithelial-mesenchymal transition in renal tubular epithelial cells through SPRY2/ERK signaling pathway.
Radiation Induces Pericyte-Myofibroblast Transition.
Chaihu Guizhi Ganjiang Decoction ameliorates chronic pancreatitis by modulating the SK1/S1P signaling pathway.
Unveiling 8,12-Dimethoxysanguinarine: A Potent Inhibitor of Breast Cancer Metastasis via Fibronectin 1 Downregulation.
13-Methylpalmatine alleviates bleomycin-induced pulmonary fibrosis by suppressing the ITGA5/TGF-β/Smad signaling pathway.
Inhibition of sphingosine 1-phosphate receptor 3 ameliorates bleomycin-induced pulmonary fibrosis by suppressing macrophage M2 polarization.
Semaphorin 3E-Plexin D1 Axis Drives Lung Fibrosis through ErbB2-Mediated Fibroblast Activation.
LncRNA SYISL promotes fibroblast myofibroblast transition via miR-23a-mediated TRIOBP regulation.
Mesenchymal stem cell exosomes regulate TGFβ/Smad3 by decreasing the METTL3-NEAT1 axis to inhibit scar progression after breast surgery.
SMARCA4 Inhibits Breast Cancer Progression and Metastasis through RHOA Suppression.
Basal and AT2 cells promote IPF-lung cancer co-occurrence via EMT: Single-cell analysis.
Vascular grafts with a mimetic microenvironment extracted from extracellular matrix of adipocytes can promote endothelialization in vivo.
Digoxin promotes anoikis of circulating cancer cells by targeting Na(+)/K(+)-ATPase α3-isoform.
A novel lncRNA ABCE1-5 regulates pulmonary fibrosis by targeting KRT14.
Preclinical studies on the antitumor and non-toxic effect of combining pirfenidone with vinorelbine and carboplatin in non-small cell lung cancer.
Lnc PVT1 facilitates TGF-β1-induced human cardiac fibroblast activation in vitro and ISO-induced myocardial fibrosis in vivo through regulating MYC.
Engineering a halloysite nanotube-enhanced hydrogel 3D skin model for modulated inflammation and accelerated wound healing.
The novel lysophosphatidic acid receptor 1-selective antagonist, ACT-1016-0707, has unique binding properties that translate into effective antifibrotic and anti-inflammatory activity in different models of pulmonary fibrosis.
Bergapten Ameliorates Renal Fibrosis by Inhibiting Ferroptosis.
Protective Effects of Lactoferrin Treatment Against Sodium Arsenite Exposure-Induced Nephrotoxicity.
Highly expressed VGLL3 in keloid fibroblasts promotes glycolysis and collagen production via the activation of Wnt/β-catenin signaling.
Silencing long non-coding RNA linc00689 suppresses the growth and invasion of osteosarcoma cells by targeting miR-129-5p/NUSAP1.
VHL ameliorates arecoline-induced oral submucosal fibrosis by promoting HDAC6 ubiquitination and blocking NF-κB pathway.
Characterization of Protein Expression and Signaling Pathway Activation That May Contribute to Differential Biological Functions in Porcine Arterial and Venous Smooth Muscle Cells.
Cyanidin-3-glucoside upregulated NDRG2 through the PI3K/AKT pathway to alleviate EMT and ECM in renal fibrosis.
Targeted Degradation of Bromodomain-Containing Protein 4 Enabled by Reactive Oxygen Species-Activatable NanoPROTACs as an Efficient Strategy to Reverse Liver Fibrosis in Chronic Liver Injury.
MDA5 protein mediating persistent ER stress/unfolded protein response contributes to endothelial-mesenchymal-transition of lung microvascular endothelial cell in dermatomyositis.
PPDPF preserves integrity of proximal tubule by modulating NMNAT activity in chronic kidney diseases.
Polo-like kinase2 regulates renal tubulointerstitial fibrosis via notch signaling pathway in diabetic kidney disease.
Expression of ENL YEATS domain tumor mutations in nephrogenic or stromal lineage impairs kidney development.
Daidzein alleviates skin fibrosis by suppressing TGF-β1 signaling pathway via targeting PKM2.
Astilbin Alleviates Radiation-Induced Pulmonary Fibrosis via circPRKCE Targeting the TGF-β/Smad7 Pathway to Inhibit Epithelial-Mesenchymal Transition.
Modulation of the Epithelial-mesenchymal transition process by Forkhead Box C2 in the repair of airway epithelium after injury.
Trimethylamine oxide promotes myocardial fibrosis through activating JAK2-STAT3 pathway.
FBXW7 mediates high glucose-induced epithelial to mesenchymal transition via KLF5 in renal tubular cells of diabetic kidney disease.
Bushen Tongluo recipe improves oxidative stress homeostasis, inhibits transforming growth factor/Notch signaling pathway, and regulates the lncRNA maternally expressed gene 3/miR-145 axis to delay diabetic kidney disease.
SRSF7 promotes pulmonary fibrosis through regulating PKM alternative splicing in lung fibroblasts.
In Vivo Reprogramming of Tissue-Derived Extracellular Vesicles for Treating Chronic Tissue Injury Through Metabolic Engineering.
Argan Callus Extract Restores Skin Cells via AMPK-Dependent Regulation of Energy Metabolism, Autophagy, and Inflammatory Pathways.
Heshuxiaoji pill suppresses steatohepatitis and fibrosis by regulating the AngII-BACH1 mediated vasoconstriction.
Notch3 enhances the synergistic effect of all-trans retinoic acid and calcipotriol in pancreatic stellate cell activation.
Ancestry-linked stromal variations impact breast epithelial cell invasion.
Lenalidomide attenuates cardiac fibrosis and inflammation induced by β-adrenergic receptor activation.
Nobiletin from Citrus reticulata Blanco alleviates pulmonary fibrosis through inhibiting the PI3K/AKT pathway and epithelial-mesenchymal transition.
Targeted Knockdown of Epithelial Estrogen Receptor α to Mitigate Ferroptosis and Epithelial-Mesenchymal Transition in Eosinophilic Asthma.
RGD peptide hydrogel downregulates mechanosignal YAP to inhibit postoperative scarring.
TCF7 functions as a prognostic biomarker in bladder cancer by strengthening EMT and stemness associated with TGF-β/SMAD3 signaling.
Fibroblast Activation Protein (FAP)(+) cancer-associated fibroblasts induce macrophage M2-like polarization via the Fibronectin 1-Integrin α5β1 axis in breast cancer.
Blocking TSP1 Ameliorates Diabetes Mellitus-Induced Erectile Dysfunction by Inhibiting the TGF-β/SMAD Pathway.
Linaggrenoids A-I, structurally diverse lindenane sesquiterpenoids with anti-hepatic fibrosis effects from Lindera aggregata.
A-485 alleviates fibrosis and apoptosis in kidney by disrupting tandem activation of acetylation and phosphorylation on STAT3.
Stiffness regulates extracellular matrix synthesis in fibroblasts by DDR1-TGF-β/STAT3 mechanotransduction axis.
Cytoplasmic and nuclear NFATc3 cooperatively contributes to vascular smooth muscle cell dysfunction and drives aortic aneurysm and dissection.
The KSR1/MEK/ERK signaling pathway promotes the progression of intrauterine adhesions.
Benzothiazole amide analogues as antagonists of TRPC 6 channels: A therapeutic approach for kidney fibrosis.
Recombinant Human Annexin A5 Ameliorates Localized Scleroderma by Inhibiting the Activation of Fibroblasts and Macrophages.
Pantothenic acid ameliorates hepatic fibrosis by targeting IGFBP6 to regulate the TGF-β/SMADs pathway.
Mefunidone treats pulmonary fibrosis by targeting SDH to regulate fibro-promoting macrophages.
Wikstdaphnoids A-I, Daphnane Diterpenoid Orthoesters from Wikstroemia chamaedaphne with Anti-Liver Fibrosis Activity.
EphrinB2 alleviates tubulointerstitial fibrosis in diabetic kidney disease.
GSR Deficiency Exacerbates Oxidative Stress and Promotes Pulmonary Fibrosis.
Timosaponin AIII alleviates type 2 diabetes-induced cardiomyopathy by targeting galectin-3 (LGALS3).
Exploring PU.1 as a Therapeutic Target to Mitigate Oxidative Stress and Inflammation in Peritoneal Dialysis-Induced Peritoneal Fibrosis.
Periostin mediates collagen production, ECM remodeling and myofibroblast differentiation in breast prosthesis capsule formation.
Negative Air Ions Attenuate Nicotine-Induced Vascular Endothelial Dysfunction by Suppressing AP1-Mediated FN1 and SPP1.
Identification and analysis of extracellular matrix and epithelial-mesenchymal transition-related genes in idiopathic pulmonary fibrosis by bioinformatics analysis and experimental validation.
Epac1 Inhibits Orbital Fibroblast Activation to Ameliorate Thyroid-Associated Orbitopathy-Like Features Through the JAK/STAT Signaling Pathway.
The miR-320a/PRDX3 Axis Alleviates the Oxidative Stress and Fibrotic Alterations in Fibroblasts in Thyroid Eye Disease.
Comparison of the effects of Liraglutide, Tirzepatide, and Retatrutide on diabetic kidney disease in db/db mice.
Cementum and enamel surface mimicry influences soft tissue cell behavior.
A polysaccharide from Glycyrrhiza uralensis attenuates myocardial fibrosis via modulating the MAPK/PI3K/AKT signaling pathway.
Sympathetic nerve promotes renal fibrosis by activating M2 macrophages through β2-AR-Gsa.
A natural small molecule alleviates liver fibrosis by targeting apolipoprotein L2.
Inhibition of PKM2 by shikonin impedes TGF-β1 expression by repressing histone lactylation to alleviate renal fibrosis.
Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection: A natural ingredient strategy.
Estrogen Receptor β Activation Mitigates Colitis-associated Intestinal Fibrosis via Inhibition of TGF-β/Smad and TLR4/MyD88/NF-κB Signaling Pathways.
Lichong decoction improves inflammatory microenvironment and alleviates fibrosis in uterine leiomyoma via targeting CXCL8.
Baricitinib represses the myocardial fibrosis via blocking JAK/STAT and TGF-β1 pathways in vivo and in vitro.
iTRAQ-Based Proteomic Analysis of Spontaneous Achilles Tendon Rupture.
Trehalose enhances macrophage autophagy to promote myelin debris clearance after spinal cord injury.
Combined ADAMTS10 and ADAMTS17 inactivation exacerbates bone shortening and compromises extracellular matrix formation.
Immunopathological characteristics and therapeutic effects of UC-MSCs in a pigeon breeder's lung mouse model.
FSTL1 aggravates high glucose-induced oxidative stress and transdifferentiation in HK-2 cells.
FN1 shapes the behavior of papillary thyroid carcinoma through alternative splicing of EDB region.
Mechanism of hsa_circ_0069443 promoting early pregnancy loss through ALKBH5/FN1 axis in trophoblast cells.
Wenshen Xiaozheng Tang alleviates fibrosis in endometriosis by regulating differentiation and paracrine signaling of endometrium-derived mesenchymal stem cells.
Bleomycin pollution and lung health: The therapeutic potential of peimine in bleomycin-induced pulmonary fibrosis by inhibiting glycolysis.
Injectable agents for the induction of Peyronie's disease in model rats: a comparative study.
Confrontation with kidney inflammation through a HMGB1-targeted peptide augments anti-fibrosis therapy.
A novel Cdc42-YAP-fibronectin signaling axis regulates ameloblast differentiation during early enamel formation.
Asiatic acid improves the damage of HaCaT cells induced by nitrogen mustard through inhibiting endoplasmic reticulum stress.
Blockade of neddylation through targeted inhibition of DCN1 alleviates renal fibrosis.
Spatial transcriptomic analysis of tumor microenvironment in esophageal squamous cell carcinoma with HIV infection.
Succinate supplementation alleviates liver cancer by inhibiting the FN1/SQLE axis-mediated cholesterol biosynthesis.
Autocrine small extracellular vesicles induce tubular phenotypic transformation in diabetic nephropathy via miR-21-5p.
A glucose-enriched lung pre-metastatic niche triggered by matrix stiffness-tuned exosomal miRNAs in hepatocellular carcinoma.
IFN-γ-mediated inhibition of JAK/STAT signaling via nano-scutellarin treatment is an efficient strategy for ameliorating liver fibrosis.
Sulfonated albumin from hepatocytes accelerates liver fibrosis in nonalcoholic fatty liver disease through endoplasmic reticulum stress.
Targeted approach to determine the impact of cancer-associated protease variants.
Miglustat ameliorates isoproterenol-induced cardiac fibrosis via targeting UGCG.
Recombinant Humanized Collagen Enhances Secreted Protein Levels of Fibroblasts and Facilitates Rats' Skin Basement Membrane Reinforcement.
Combined ADAMTS10 and ADAMTS17 inactivation exacerbates bone shortening and skin phenotypes.
PAI-1 deficiency inhibits endometrial fibrosis via modulation of the FAK/Src/ERK and AKT signalling pathways.
Panaxatriol saponins exert anti-renal fibrosis by suppressing TNF-α mediated inflammation and TGF-β1/Smad3 signaling pathway.
Protective effect of phosphoenolpyruvate carboxykinase 1 on inflammation and fibrotic progression of IgA nephropathy.
The role and mechanisms of the microRNA-1180-3p/MKNK2/CREB3 signaling axis in tumor progression following insufficient radiofrequency ablation of colorectal cancer liver metastasis.
The multifaceted modulations by dapagliflozin in preventing hyperglycemia-induced diabetic nephropathy through glucose transporters and PPARα.
Stellarin I: A Bioactive Cyclic Nonapeptide with Potent Anti-renal Fibrosis Activity from the Root of Stellaria yunnanensis Franch.
Formononetin, a Key Component of Danggui Buxue Decoction, Inhibits Metastasis of Triple-Negative Breast Cancer by Modulating SNAI2-Driven EMT.
Autophagy-dependent secretion of ENO1 mediates chemoresistance of glioblastoma and tumor microenvironment remodeling.
The novel circular RNA circG6pc attenuates oxidative stress and mitochondrial damage through miR-7018-5p/Aldh6a1 axis in kidney fibrosis.
Neutrophil extracellular traps promote bone loss in type 1 diabetes via suppression of the FN1-PI3K/Akt signaling axis.
Six1 promotes alveolar epithelium senescence in pulmonary fibrosis through regulating Tp53.
The role and mechanism of ARRB1 in simulated space radiation and microgravity-induced lung carcinogenesis.
Sustained mesenchymal reprogramming of endothelial cells after completion of chemotherapy.
Dual-functional nanovesicles simultaneously inhibit stromal fibrosis and angiogenesis to suppress cholangiocarcinoma progression.
High matrix stiffness triggers the YAP-OPA1-TET1/3 loop to drive chemoresistance via enhanced nuclear-mitochondrial communication.
Multi-omics factor analysis identifies the Tensin 1-Fermitin family homologue 2-Fibronectin 1-Integrin signaling axis as a prognostic determinant in colorectal cancer.
NAT10-mediated N4-acetylcytidine (ac4C) modification of PIK3R2 mRNA promotes malignant progression of glioblastoma.
Fat-targeted small molecule alleviates abnormal adipose tissue remodeling in obesity via SIRT3-driven mitophagy and inflammasome inhibition.
De-ubiquitinase USP35 promotes peritoneal dissemination of gastric cancer by regulating metabolic reprogramming.
Uremic serum exposure leads to differential phenotypic switch in porcine arterial and venous smooth muscle cells.
Cell Division Cycle 42 Improves Renal Functions, Fibrosis, Th1/Th17 Infiltration and Inflammation to Some Degree in Diabetic Nephropathy.
Nerandomilast Improves Bleomycin-Induced Systemic Sclerosis-Associated Interstitial Lung Disease in Mice by Regulating the TGF-β1 Pathway.
Reprogramming peritoneal macrophages with outer membrane vesicle-coated PLGA nanoparticles for endometriosis prevention.
Role of UVA-driven cellular senescence via mTOR activation in dihydrotestosterone-induced hair loss in androgenetic alopecia mouse model.
Revealing a new target: Celastrol alleviates pulmonary fibrosis by inhibiting PCAF.
Curdione inhibits the proliferation of human uterine leiomyomas by targeting YTHDF1.
F-box only protein 10 protects against kidney tubulointerstitial fibrosis by inhibiting ACSL4-mediated lipid peroxidation and ferroptosis.
Rehmannioside A alleviates renal inflammation and fibrosis in hypertensive nephropathy via AT1R/MAPK14/IL-17 signaling pathway.
Assessments of neurogenic bladder dysfunction induced by spinal cord injury, bladder outlet obstruction and diabetes: a comparative study of rat models.
Kurarinone protects against renal injury and fibrosis after unilateral ureteral obstruction through enhancement of the Nrf-2 signaling pathway.
S100a8 inhibitor Paquinimod attenuates coal dust-induced pulmonary fibrosis via blocking neutrophils-S100a8-Tlr4-macrophages signaling axis.
Low-protein Calorie-restriction Mitigates Diabetic Mice Kidney Injury via the Gut-Kidney Axis.
MSC-derived exosomes improve endometrial fibrosis via the lncRNA IGF2R/ miR-143-5p/AQP8 axis.
[Haematococcus pluvialis alleviates bleomycin-induced pulmonary fibrosis in mice by inhibiting transformation of lung fibroblasts into myofibroblast].
Nintedanib inhibits neovascularization and subretinal fibrosis in a laser-induced choroidal neovascularization mouse model.
NAT10 Mediates Cardiac Fibrosis Induced by Myocardial Infarction Through ac4C Modification of TGFBR1 mRNA.
Ergosterol from edible fungi: Enhancing fatty acid oxidation via CPT1A to protect against diabetic kidney disease.
TGF-β1 induces ROS to activate ferroptosis via the ERK1/2-WISP1 pathway to promote the progression of renal tubular epithelial cell fibrosis.
Inhibition of bone morphogenetic protein 4 alleviates angiotensin II-induced abdominal aortic aneurysm by reducing inflammation and endothelial-mesenchymal transition.
Recombinant Humanized Collagen: A Promising Treatment for Pelvic Organ Prolapse via Enhanced Fibroblast Function and Angiogenesis.
CIP2A promotes bronchiolitis obliterans by activating the NF‑κB pathway.
HDAC3 and Snail2 complex promotes melanoma metastasis by epigenetic repression of IGFBP3.
Pinocembrin alleviates renal ischemia-reperfusion injury/unilateral ureteral obstruction (UUO)-generated renal fibrosis by targeting the CYP1B1/ROS/MAPK axis.
GABP Promotes Mesangial Cell Proliferation and Renal Fibrosis Through GLI1 in Diabetic Nephropathy.
Deletion of Pyruvate Carboxylase in Tubular Epithelial Cell Promotes Renal Fibrosis by Regulating SQOR/cGAS/STING-Mediated Glycolysis.
Mechanism of Mitophagy to Protect Yak Kidney from Hypoxia-Induced Fibrosis Damage by Regulating Ferroptosis Pathway.
AMPK is dispensable for physiological podocyte and glomerular functions but prevents glomerular fibrosis in experimental diabetes.
Cancer-associated fibroblasts secrete CSF3 to promote TNBC progression via enhancing PGM2L1-dependent glycolysis reprogramming.
LncRNA-5829: a novel inhibitor of cardiac fibrosis.
Cathepsin B promotes optic nerve axonal regeneration.
MicroRNA-122-5p is upregulated in diabetic foot ulcers and decelerates the transition from the inflammatory to the proliferative stage.
Dehydrocorydaline attenuates bleomycin-induced pulmonary fibrosis by inhibiting fibroblast activation.
Inhibition of Rho GEFs attenuates pulmonary fibrosis through suppressing myofibroblast activation and reprogramming profibrotic macrophages.
NELL2, a novel osteoinductive factor, regulates osteoblast differentiation and bone homeostasis through fibronectin 1/integrin-mediated FAK/AKT signaling.
The CD163 + tissue-infiltrating macrophages regulate ferroptosis in thyroid-associated ophthalmopathy orbital fibroblasts via the TGF-β/Smad2/3 signaling pathway.
Proliferator-Activated Receptor Alpha Inhibits Abnormal Extracellular Matrix Accumulation and Maintains Energy Metabolism in Late-Onset Fuchs Endothelial Corneal Dystrophy.
Spatial Regulation of Cancer-Associated Fibroblasts and Tumor Cells via pH-Responsive Bispecific Antibody Delivery for Enhanced Chemo-Immunotherapy Synergy.
Astragaloside I from Astragalus Attenuates Diabetic Kidney Disease by Regulating HDAC3/Klotho/TGF-β1 Loop.
Expression and Clinicopathological Significance of Extracellular Matrix Remodeling Markers in Esophageal Squamous Carcinoma.
An In Situ Sustained-Release Chitosan Hydrogel to Attenuate Renal Fibrosis by Retaining Klotho Expression.
PTPLAD1 Regulates PHB-Raf Interaction to Orchestrate Epithelial-Mesenchymal and Mitofusion-Fission Transitions in Colorectal Cancer.
Lysozyme promotes renal fibrosis through the JAK/STAT3 signal pathway in diabetic nephropathy.
Highly Ordered Nanotube-Like Microstructure on Titanium Dental Implant Surface Fabricated via Anodization Enhanced Cell Adhesion and Migration of Human Gingival Fibroblasts.
Targeting transcription factor pu.1 for improving neurologic outcomes after spinal cord injury.
Bone morphogenetic protein-6 suppresses TGF-β(2)-induced epithelial-mesenchymal transition in retinal pigment epithelium.
MicroRNA-204-5p Ameliorates Renal Injury via Regulating Keap1/Nrf2 Pathway in Diabetic Kidney Disease.
ETS1 Expression in Diabetic Foot Ulcers: Implications for Fibroblast Phenotype and Wound Healing Through the PP2A/YAP Pathway.
Identification and verification of the optimal feature genes of ferroptosis in thyroid-associated orbitopathy.
Acute exposure to ultraviolet radiation targets proteins involved in collagen fibrillogenesis.
Quantitative proteomics reveals the protective effects of Yinchenzhufu decoction against cholestatic liver fibrosis in mice by inhibiting the PDGFRβ/PI3K/AKT pathway.
Nicotinamide phosphoribosyltransferase prompts bleomycin-induced pulmonary fibrosis by driving macrophage M2 polarization in mice.
Abnormal mitochondrial iron metabolism damages alveolar type II epithelial cells involved in bleomycin-induced pulmonary fibrosis.
Vitamin D binding protein (VDBP) hijacks twist1 to inhibit vasculogenic mimicry in hepatocellular carcinoma.
ELMO1 ameliorates intestinal epithelial cellular senescence via SIRT1/p65 signaling in inflammatory bowel disease-related fibrosis.
Mefunidone alleviates silica-induced inflammation and fibrosis by inhibiting the TLR4-NF-κB/MAPK pathway and attenuating pyroptosis in murine macrophages.
PRM1201 effectively inhibits colorectal cancer metastasis via shaping gut microbiota and short- chain fatty acids.
Mechanism of Zhenwu Decoction modulating TLR4/NF-κB/HIF-1α loop through miR-451 to delay renal fibrosis in type 2 CRS.
Dihydromyricetin ameliorates diabetic renal fibrosis via regulating SphK1 to suppress the activation of NF-κB pathway.
Deletion of ASPP1 in myofibroblasts alleviates myocardial fibrosis by reducing p53 degradation.
Combination of arsenic trioxide and apatinib synergistically inhibits small cell lung cancer by down-regulating VEGFR2/mTOR and Akt/c-Myc signaling pathway via GRB10.
IKKα-STAT3-S727 axis: a novel mechanism in DOX-induced cardiomyopathy.
Novel Iridoid Derivatives Isolated from the Roots of Patrinia scabra with Potential Anti-Renal Fibrosis Activity In Vitro.
PMMA-induced biofilm promotes Schwann cells migration and proliferation mediated by EGF/Tnc/FN1 to improve sciatic nerve defect.
Mechanosensitive Piezo1 channels promote neurogenic bladder fibrosis via regulating TGF-β1/smad and Hippo/YAP1 pathways.
Attenuation of renal fibrosis in mice due to lack of bombesin receptor-activated protein homologue.
CircNSD1 promotes cardiac fibrosis through targeting the miR-429-3p/SULF1/Wnt/β-catenin signaling pathway.
Regulation of Fuzheng Huayu capsule on inhibiting the fibrosis-associated hepatocellular carcinogenesis.
RELA-mediated upregulation of LINC03047 promotes ferroptosis in silica-induced pulmonary fibrosis via SLC39A14.
Odontogenesis-Empowered Extracellular Vesicles Safeguard Donor-Recipient Stem Cell Interplay to Support Tooth Regeneration.
Targeting SOCS2 alleviates myocardial fibrosis by reducing nuclear translocation of β-catenin.
GPR176 promotes fibroblast-to-myofibroblast transition in organ fibrosis progression.
High-dose vitamin C attenuates radiation-induced pulmonary fibrosis by targeting S100A8 and S100A9.
ETS1 and RBPJ transcriptionally regulate METTL14 to suppress TGF-β1-induced epithelial-mesenchymal transition in human bronchial epithelial cells.
Cinnamaldehyde activates AMPK/PGC-1α pathway via targeting GRK2 to ameliorate heart failure.
Perinatal nicotine vaping exposure induces pro-myofibroblastic phenotype in rat bone marrow-derived mesenchymal stem cells.
Hypoxia-induced DTL promotes the proliferation, metastasis, and sorafenib resistance of hepatocellular carcinoma through ubiquitin-mediated degradation of SLTM and subsequent Notch pathway activation.
Albendazole ameliorates aerobic glycolysis in myofibroblasts to reverse pulmonary fibrosis.
TRβ activation confers AT2-to-AT1 cell differentiation and anti-fibrosis during lung repair via KLF2 and CEBPA.
Baricitinib alleviates cardiac fibrosis and inflammation induced by chronic sympathetic activation.
Mitochondrial MOF regulates energy metabolism in heart failure via ATP5B hyperacetylation.
CCT6A alleviates pulmonary fibrosis by inhibiting HIF-1α-mediated lactate production.
MiR-1307-5p enhances fibroblast transdifferentiation to exacerbate chronic obstructive pulmonary disease through regulating FBXL16/HIF1α axis.
Hydrogen-releasing magnesium hydrogel mitigates post laminectomy epidural fibrosis through inhibition of neutrophil extracellular traps.
Asiaticoside improves diabetic nephropathy by reducing inflammation, oxidative stress, and fibrosis: An in vitro and in vivo study.
Galectin-3 inhibition reduces fibrotic scarring and promotes functional recovery after spinal cord injury in mice.
Peripheral dopamine suppression and elevated cystatin C in early diabetic nephropathy in spontaneously diabetic rats.
Cell Communications Between GCs and Macrophages Contribute to the Residence of Macrophage in Preovulatory Follicles.
The LncRNA6524/miR-92a-2-5p/Dvl1/Wnt/β-catenin axis promotes renal fibrosis in the UUO mouse model.
Gene Profiling of Circular RNAs in Keloid-prone Individuals and ceRNA Network Construction During Wound Healing.
Exosomal miR-552-3p isolated from BALF of patients with silicosis induces fibroblast activation.
Tenascin-C induces transdifferentiation of retinal pigment epithelial cells in proliferative vitreoretinopathy.
Dietary sodium modulates mTORC1-dependent trained immunity in macrophages to accelerate CKD development.
LncRNA H19 accelerates renal fibrosis by negatively regulating the let-7b-5p/TGF-βR1/COL1A1 axis.
Three-Dimensional Semiconductor Network as Regulators of Energy Metabolism Drives Angiogenesis in Bone Regeneration.
DsbA-L activates TGF-β1/SMAD3 signaling and M2 macrophage polarization by stimulating AKT1 and NLRP3 to promote pulmonary fibrosis.
Ficolin-1 ameliorates pulmonary fibrosis via directly binding to TGF-β1.
The in vivo effects of knockdown of long non-coding RNA XIST on fibroid growth and gene expression.
P2Y12-targeted modulation of microglial phenotypes: A novel therapeutic strategy for enhanced axonal regeneration post-spinal cord injury.
CD8(+) tissue-resident memory T cells are essential in bleomycin-induced pulmonary fibrosis.
Gaudichaudione H ameliorates liver fibrosis and inflammation by targeting NRF2 signaling pathway.
Exposure to micron-grade silica particles triggers pulmonary fibrosis through cell-to-cell delivery of exosomal miR-107.
TGF-β1 inhibitor P144 protects against benign restenosis after esophageal stenting through TGF-β1/Smads signaling pathway inhibition.
Kefir peptides mitigate bleomycin-induced pulmonary fibrosis in mice through modulating oxidative stress, inflammation and gut microbiota.
Pirfenidone alleviates fibrosis by acting on tumour-stroma interplay in pancreatic cancer.
SOAT1 regulates cholesterol metabolism to induce EMT in hepatocellular carcinoma.
Effects of Nanoparticle-Mediated Dihydromyricetin to Diabetic Wounds: An In Vivo Study.
Describing the Cellular Impact of IQOS™ Smoke Extract and Vibration on Human Vocal Fold Fibroblasts.
Human amnion mesenchymal stem cells promote endometrial repair via paracrine, preferentially than transdifferentiation.
Lactate facilitated mitochondrial fission-derived ROS to promote pulmonary fibrosis via ERK/DRP-1 signaling.
The role of FERMT2 in the tumor microenvironment and immunotherapy in pan-cancer using comprehensive single-cell and bulk sequencing.
Generation and application of immortalized sheep fetal fibroblast cell line.
The Rejuvenation and Functional Restoration of Aged Adipose Stem Cells by DUXAP10 Knockdown via the Regulation of the miR-214-3p/RASSF5 Axis.
Ribosomal Dysregulation in Metastatic Laryngeal Squamous Cell Carcinoma: Proteomic Insights and CX-5461's Therapeutic Promise.
Targeting RORγ inhibits the growth and metastasis of hepatocellular carcinoma.
Remimazolam attenuates inflammation and kidney fibrosis following folic acid injury.
Astaxanthin attenuates cigarette smoke-induced small airway remodeling via the AKT1 signaling pathway.
Wnt5a/β-catenin-mediated epithelial-mesenchymal transition: a key driver of subretinal fibrosis in neovascular age-related macular degeneration.
Nuciferine reduces vascular leakage and improves cardiac function in acute myocardial infarction by regulating the PI3K/AKT pathway.
PDE12 disrupts mitochondrial oxidative phosphorylation and mediates mitochondrial dysfunction to induce oral mucosal epithelial barrier damage in oral submucous fibrosis.
Fibroblast-Specific Depletion of Human Antigen R Alleviates Myocardial Fibrosis Induced by Cardiac Stress.
Preventive effects of Ramelteon on bleomycin-induced pulmonary fibrosis in mice.
Kokusaginine attenuates renal fibrosis by inhibiting the PI3K/AKT signaling pathway.
Synergistic effects of photodynamic therapy and chemotherapy: Activating the intrinsic/extrinsic apoptotic pathway of anoikis for triple-negative breast cancer treatment.
Modified mRNA-Mediated CCN5 Gene Transfer Ameliorates Cardiac Dysfunction and Fibrosis without Adverse Structural Remodeling.
Platelet membrane biomimetic nanoparticle-targeted delivery of TGF-β1 siRNA attenuates renal inflammation and fibrosis.
The Development of a 3D PET Fibrous Scaffold Modified with an Umbilical Cord dECM for Liver Tissue Engineering.
In Vivo Effects of Bay 11-7082 on Fibroid Growth and Gene Expression: A Preclinical Study.
Fibronectin-Targeting Dual-Modal MR/NIRF Imaging Contrast Agents for Diagnosis of Gastric Cancer and Peritoneal Metastasis.
Targeting the long non-coding RNA MIAT for the treatment of fibroids in an animal model.
Bone transport induces the release of factors with multi-tissue regenerative potential for diabetic wound healing in rats and patients.
Hyperbaric oxygen enhances tumor penetration and accumulation of engineered bacteria for synergistic photothermal immunotherapy.
Xinbao Pill ameliorates heart failure via regulating the SGLT1/AMPK/PPARα axis to improve myocardial fatty acid energy metabolism.
YAP1 inhibits the senescence of alveolar epithelial cells by targeting Prdx3 to alleviate pulmonary fibrosis.
Parkin deficiency promotes liver cancer metastasis by TMEFF1 transcription activation via TGF-β/Smad2/3 pathway.
Silibinin attenuates TGF-β2-induced fibrogenic changes in human trabecular meshwork cells by targeting JAK2/STAT3 and PI3K/AKT signaling pathways.
Picroside II promotes HSC apoptosis and inhibits the cholestatic liver fibrosis in Mdr2(-/-) mice by polarizing M1 macrophages and balancing immune responses.
Long Non-coding RNA ZFAS1 Regulates Fibrosis and Scortosis in the Cell Model of Diabetic Nephropathy Through miR-525-5p/SGK1 Axis.
The histone deacetylase inhibitor MS-275 enhances the matrix mineralization of dental pulp stem cells by inducing fibronectin expression.
Hydrogen Therapy Reverses Cancer-Associated Fibroblasts Phenotypes and Remodels Stromal Microenvironment to Stimulate Systematic Anti-Tumor Immunity.
DKK1 loss promotes endometrial fibrosis via autophagy and exosome-mediated macrophage-to-myofibroblast transition.
Icariside II modulates pulmonary fibrosis via PI3K/Akt/β-catenin pathway inhibition of M2 macrophage program.
Endothelial progenitor cells control remodeling of uterine spiral arteries for the establishment of utero-placental circulation.
Epithelial CEBPD activates fibronectin and enhances macrophage adhesion in renal ischemia-reperfusion injury.
Inhalation of hydrogen gas protects against mitomycin-induced pulmonary veno-occlusive disease.
Procyanidin C1 inhibits bleomycin-induced pulmonary fibrosis in mice by selective clearance of senescent myofibroblasts.
CD24 promotes metastasis and chemoresistance by directly targeting Arf6-ERK pathway in esophageal squamous cell carcinoma.
Cell fusion upregulates PD-L1 expression for evasion from immunosurveillance.
Chitosan-based oral nanoparticles as an efficient platform for kidney-targeted drug delivery in the treatment of renal fibrosis.
Lactate accumulation induced by Akt2-PDK1 signaling promotes pulmonary fibrosis.
In silico prediction and experimental validation to reveal the protective mechanism of Puerarin against excessive extracellular matrix accumulation through inhibiting ferroptosis in diabetic nephropathy.
A cardiotoxicity-eliminated ACE2 variant as a pan-inhibitor against coronavirus cell invasion.
Inhibition of heme oxygenase 1 alleviates thoracic aortic aneurysm via restoration of extracellular matrix.
Rehmannia glutinosa Libosch and Cornus officinalis Sieb herb couple ameliorates renal interstitial fibrosis in CKD rats by inhibiting the TGF-β1/MAPK signaling pathway.
hPMSCs Regulate the Level of TNF-α and IL-10 in Th1 Cells and Improve Hepatic Injury in a GVHD Mouse Model via CD73/ADO/Fyn/Nrf2 Axis.
Microplastics cause hepatotoxicity in diabetic mice by disrupting glucolipid metabolism via PP2A/AMPK/HNF4A and promoting fibrosis via the Wnt/β-catenin pathway.
Alleviative Effect of Lactoferrin Interventions Against the Hepatotoxicity Induced by Titanium Dioxide Nanoparticles.
Targeting ROCK1 in diabetic kidney disease: Unraveling mesangial fibrosis mechanisms and introducing myricetin as a novel antagonist.
Discovery of PRDM16-Mediated TRPA1 Induction as the Mechanism for Low Tubulo-Interstitial Fibrosis in Diabetic Kidney Disease.
Endothelial Robo4 suppresses endothelial-to-mesenchymal transition induced by irradiation and improves hematopoietic reconstitution.
Forensic significance of intracardiac expressions of Nrf2 in acute myocardial ischemia.
Endothelium-specific deletion of p62 causes organ fibrosis and cardiac dysfunction.
Up-regulation of long non-coding RNA H19 ameliorates renal tubulointerstitial fibrosis by reducing lipid deposition and inflammatory response through regulation of the microRNA-130a-3p/long-chain acyl-CoA synthetase 1 axis.
METTL3 silencing inhibits ferroptosis to suppress ovarian fibrosis in PCOS by upregulating m6A modification of GPX4.
Chronic exposure to polystyrene microplastics induces renal fibrosis via ferroptosis.
MiR-454-3p regulates high glucose-induced mesothelial-mesenchymal transition and glycolysis in peritoneal mesothelial cells by targeting STAT3.
Oridonin ameliorates renal fibrosis in diabetic nephropathy by inhibiting the Wnt/β-catenin signaling pathway.
Iguratimod prevents renal fibrosis in unilateral ureteral obstruction model mice by suppressing M2 macrophage infiltration and macrophage-myofibroblast transition.
Mesenchymal stem cells may alleviate angiotensin II-induced myocardial fibrosis and hypertrophy by upregulating SFRS3 expression.
Aristolochic acid I promotes renal tubulointerstitial fibrosis by up-regulating expression of indoleamine 2,3-dioxygenase-1 (IDO1).
Pachymic acid ameliorates bleomycin-induced pulmonary fibrosis through inhibiting endoplasmic reticulum stress in rats.
Cell Sheets Formation Enhances Therapeutic Effects of Human Umbilical Cord Mesenchymal Stem Cells on Spinal Cord Injury.
Methane saline suppresses ferroptosis via the Nrf2/HO-1 signaling pathway to ameliorate intestinal ischemia-reperfusion injury.
MSCs-derived ECM functionalized hydrogel regulates macrophage reprogramming for osteoarthritis treatment by improving mitochondrial function and energy metabolism.
Tissue-engineered collagen matrix loaded with rat adipose-derived stem cells/human amniotic mesenchymal stem cells for rotator cuff tendon-bone repair.
Dihydrolipoamide S-acetyltransferase activation alleviates diabetic kidney disease via AMPK-autophagy axis and mitochondrial protection.
Calpain-1 Up-Regulation Promotes Bleomycin-Induced Pulmonary Fibrosis by Activating Ferroptosis.
Suyin Detoxification Granule alleviates trimethylamine N-oxide-induced tubular ferroptosis and renal fibrosis to prevent chronic kidney disease progression.
Cardioprotective effects of polydatin against myocardial injury in HFD/stz and high glucose-induced diabetes via a Caveolin 1-dependent mechanism.
Quercetin prevents the USP22-Snail1 signaling pathway to ameliorate diabetic tubulointerstitial fibrosis.
The role of the PI3K/AKT/mTOR pathway in mediating PD-L1 upregulation during fibroblast transdifferentiation.
Clostridium difficile-derived membrane vesicles promote fetal growth restriction via inhibiting trophoblast motility through PPARγ/RXRα/ANGPTL4 axis.
Dual rectification of metabolism abnormality in pancreatic cancer by a programmed nanomedicine.
Ancestry-linked stromal variations impact breast epithelial cell invasion.
METTL14 downregulates GLUT9 through m6A methylation and attenuates hyperuricemia-induced fibrosis in mouse renal tubular epithelial cells.
Baicalin improves isoproterenol-induced cardiac remodeling by regulating the Nrf2-dependent signaling pathway.
GS-4997 halts the progression of tubulointerstitial injury in lupus nephritis.
PAI-1 promotes human endometrial stromal decidualization via inhibiting VEGFR2/PI3K/AKT signaling pathway mediated F-actin reorganization.
Ameliorating lung fibrosis and pulmonary function in diabetic mice: Therapeutic potential of mesenchymal stem cell.
Serum deprivation protein response intervenes in the proliferation, motility, and extracellular matrix production in keloid fibroblasts by blocking the amplification of TGF-β1/SMAD signal cascade via ERK1/2.
Macromolecular Crowding Enhances Matrix Protein Deposition in Tissue-Engineered Vascular Grafts.
Aging-Associated Metabolite Methylmalonic Acid Increases Susceptibility to Pulmonary Fibrosis.
Aldehyde Dehydrogenase 2 Deficiency Aggravates Lung Fibrosis through Mitochondrial Dysfunction and Aging in Fibroblasts.
Lipoamide Attenuates Hypertensive Myocardial Hypertrophy Through PI3K/Akt-Mediated Nrf2 Signaling Pathway.
STC2 suppresses triple-negative breast cancer migration and invasion by inhibition on EMT and promotion on cell apoptosis.
The SGLT2 inhibitor dapagliflozin ameliorates renal fibrosis in hyperuricemic nephropathy.
CD146-dependent macrophage infiltration promotes epidural fibrosis via the Erdr1/ERK/CCR2 pathway.
CD47 and IFT57 Are Colinear Genes That Are Highly Coexpressed in Most Cancers and Exhibit Parallel Cancer-Specific Correlations with Survival.
Peptostreptococcus stomatis promotes colonic tumorigenesis and receptor tyrosine kinase inhibitor resistance by activating ERBB2-MAPK.
Single-Cell Analyses Reveal the Metabolic Heterogeneity and Plasticity of the Tumor Microenvironment during Head and Neck Squamous Cell Carcinoma Progression.
VDR regulates mitochondrial function as a protective mechanism against renal tubular cell injury in diabetic rats.
BMSC-derived Exosomes Ameliorate Peritoneal Dialysis-associated Peritoneal Fibrosis via the Mir-27a-3p/TP53 Pathway.
Bone morphogenetic protein 6 (BMP6) antagonises experimental proliferative vitreoretinopathy established by TGF-β2 stimulation in retinal pigment epithelial cells through modulation of the p38 and JNK MAPK pathways.
The regulatory role of the apelin/APJ axis in scarring: Identification of upstream and downstream mechanisms.
Therapeutic effects of in vivo administration of an inhibitor of tryptophan 2,3-dioxygenase (680c91) for the treatment of fibroids: a preclinical study.
Intimomedial tears of the aorta heal by smooth muscle cell-mediated fibrosis without atherosclerosis.
NBR1-p62-Nrf2 mediates the anti-pulmonary fibrosis effects of protodioscin.
DEC1 is involved in circadian rhythm disruption-exacerbated pulmonary fibrosis.
Jin-Gui-Shen-Qi Wan alleviates fibrosis in mouse diabetic nephropathy via MHC class II.
Favipiravir ameliorates bleomycin-induced pulmonary fibrosis by reprogramming M1/M2 macrophage polarization.
Bioinformatics-based dynamics of cuproptosis -related indicators in experimental silicosis.
Propofol improves ischemia reperfusion-induced liver fibrosis by regulating lncRNA HOXA11-AS.
Up-regulated SPP1 increases the risk from IPF to lung cancer via activating the pro-tumor macrophages.
hucMSC-Ex Alleviates IBD-Associated Intestinal Fibrosis by Inhibiting ERK Phosphorylation in Intestinal Fibroblasts.
FAT10 Silencing Prevents Liver Fibrosis through Regulating SIRT1 Expression in Hepatic Stellate Cells.
Combining Porous Se@SiO(2) Nanocomposites and dECM Enhances the Myogenic Differentiation of Adipose-Derived Stem Cells.
Effects of autophagy inhibitor 3-methyladenine on a diabetic mice model.
Irisin Ameliorates Renal Tubulointerstitial Fibrosis by Regulating the Smad4/β-Catenin Pathway in Diabetic Mice.
CXCL5 knockdown attenuated gemcitabine resistance of pancreatic cancer through regulation of cancer cells and tumour stroma.
Identification and validation of chemokine system-related genes in idiopathic pulmonary fibrosis.
Apolipoprotein A-I attenuates peritoneal fibrosis associated with peritoneal dialysis by inhibiting oxidative stress and inflammation.
Dapagliflozin alleviates renal fibrosis in a mouse model of adenine-induced renal injury by inhibiting TGF-β1/MAPK mediated mitochondrial damage.
Gastrodin attenuates renal injury and collagen deposition via suppression of the TGF-β1/Smad2/3 signaling pathway based on network pharmacology analysis.
EZH2 and matrix co-regulate phenotype and KCNB2 expression in bladder smooth muscle cells.
Differentially expressed genes in orbital adipose/connective tissue of thyroid-associated orbitopathy.
Ferroptosis-dependent breast cancer cell-derived exosomes inhibit migration and invasion of breast cancer cells by suppressing M2 macrophage polarization.
Sclareol attenuates liver fibrosis through SENP1-mediated VEGFR2 SUMOylation and inhibition of downstream STAT3 signaling.
Embryo-uterine interaction coordinates mouse embryogenesis during implantation.
Omentin-1 induces mechanically activated fibroblasts lipogenic differentiation through pkm2/yap/pparγ pathway to promote lung fibrosis resolution.
Long non-coding RNA MIDEAS-AS1 inhibits growth and metastasis of triple-negative breast cancer via transcriptionally activating NCALD.
Multi-targeting liposomal codelivery of cisplatin and rapamycin inhibits pancreatic cancer growth and metastasis through stromal modulation.
Fraxin represses NF-κB pathway via inhibiting the activation of epidermal growth factor receptor to ameliorate diabetic renal tubulointerstitial fibrosis.
Targeting STING-mediated pro-inflammatory and pro-fibrotic effects of alveolar macrophages and fibroblasts blunts silicosis caused by silica particles.
Qingda granule ameliorates vascular remodeling and phenotypic transformation of adventitial fibroblasts via suppressing the TGF-β1/Smad2/3 pathway.
MYCT1 attenuates renal fibrosis and tubular injury in diabetic kidney disease.
Nephroprotective Effects of Cardamonin on Renal Ischemia Reperfusion Injury/UUO-Induced Renal Fibrosis.
N-methylpiperazine-diepoxyovatodiolide ameliorates peritoneal fibrosis via suppressing TGF-β/Smad and JAK/STAT signaling pathway.
Ceruloplasmin regulating fibrosis in orbital fibroblasts provides a novel therapeutic target for Graves' orbitopathy.
Pregnane X receptor activation alleviates renal fibrosis in mice via interacting with p53 and inhibiting the Wnt7a/β-catenin signaling.
Nucleosome assembly protein 1 like 1 (NAP1L1) promotes cardiac fibrosis by inhibiting YAP1 ubiquitination and degradation.
Can targeted nanoparticles distinguish cancer metastasis from inflammation?
KCTD4 interacts with CLIC1 to disrupt calcium homeostasis and promote metastasis in esophageal cancer.
Fu-Zheng-Tong-Luo formula promotes autophagy and alleviates idiopathic pulmonary fibrosis by controlling the Janus kinase 2/signal transducer and activator of transcription 3 pathway.
Neuroepithelial cell-transforming 1 promotes cardiac fibrosis via the Wnt/β-catenin signaling pathway.
Proximal Tubular Lats2 Ablation Exacerbates Ischemia/Reperfusion Injury (IRI)-Induced Renal Maladaptive Repair through the Upregulation of P53.
Liraglutide intervention improves high-glucose-induced reactive gliosis of Müller cells and ECM dysregulation.
Mannan-binding lectin ameliorates renal fibrosis by suppressing macrophage-to-myofibroblast transition.
Local administration of liposomal-based Plekhf1 gene therapy attenuates pulmonary fibrosis by modulating macrophage polarization.
Hyperbranched polyamidoamine-RGD peptide/si-circICA1 in the treatment of invasive thyroid cancer through targeting of the miR-486-3p/SERPINA1 axis.
SETD2 deficiency promotes renal fibrosis through the TGF-β/Smad signalling pathway in the absence of VHL.
Melatonin exerts a protective effect in ameliorating nephrolithiasis via targeting AMPK/PINK1-Parkin mediated mitophagy and inhibiting ferroptosis in vivo and in vitro.
Guanxin V alleviates ventricular remodeling by promoting transforming growth factor-beta 1-mediated proteasomal degradation of Vimentin.
Defining the identity and the niches of epithelial stem cells with highly pleiotropic multilineage potency in the human thymus.
Prolonged exposure to the herbicide atrazine promotes kidney fibrosis by activating Wnt/β-catenin signaling in rats.
CircRNA_0017076 acts as a sponge for miR-185-5p in the control of epithelial-to-mesenchymal transition of tubular epithelial cells during renal interstitial fibrosis.
Lysine 2-hydroxyisobutyrylation of NAT10 promotes cancer metastasis in an ac4C-dependent manner.
Nicotine exposure exacerbates silica-induced pulmonary fibrosis via STAT3-BDNF-TrkB-mediated epithelial-mesenchymal transition in alveolar type II cells.
HDAC9-mediated epithelial cell cycle arrest in G2/M contributes to kidney fibrosis in male mice.
Splicing factor YBX1 regulates bone marrow stromal cell fate during aging.
Crosstalk between the JAK2 and TGF-β1 signaling pathways in scleroderma-related interstitial lung disease targeted by baricitinib.
Ginsenoside Rb1 promotes the activation of PPARα pathway via inhibiting FADD to ameliorate heart failure.
USP22 aggravated diabetic renal tubulointerstitial fibrosis progression through deubiquitinating and stabilizing Snail1.
Aristolocholic acid I promotes renal tubular epithelial fibrosis by upregulating matrix metalloproteinase-9 expression via activating the C3a/C3aR axis of macrophages.
PRMT2 promotes RCC tumorigenesis and metastasis via enhancing WNT5A transcriptional expression.
Yishen Tongluo formula alleviates diabetic kidney disease through regulating Sirt6/TGF-β1/Smad2/3 pathway and promoting degradation of TGF-β1.
Interferon regulatory factor 4 deletion protects against kidney inflammation and fibrosis in deoxycorticosterone acetate/salt hypertension.
N4-acetylcytidine modification of lncRNA CTC-490G23.2 promotes cancer metastasis through interacting with PTBP1 to increase CD44 alternative splicing.
Rapid formation of 3D: Decellularized extracellular matrix spheroids for enhancing bone formation.
Cardioprotective and anti-inflammatory effects of Caveolin 1 in experimental diabetic cardiomyopathy.
Sustainably released nanoparticle-based rhynchophylline limits pulmonary fibrosis by inhibiting the TEK-PI3K/AKT signaling pathway.
Combination of pioglitazone, a PPARγ agonist, and synthetic surfactant B-YL prevents hyperoxia-induced lung injury in adult mice lung explants.
ROS promote hyper-methylation of NDRG2 promoters in a DNMTS-dependent manner: Contributes to the progression of renal fibrosis.
GPR97 deficiency ameliorates renal interstitial fibrosis in mouse hypertensive nephropathy.
ZNF133 is a potent suppressor in breast carcinogenesis through dampening L1CAM, a driver for tumor progression.
GYY4137, a H(2)S donor, ameliorates kidney injuries in diabetic mice by modifying renal ROS-associated enzymes.
Mitochondrial folate pathway regulates myofibroblast differentiation and silica-induced pulmonary fibrosis.
AAV9-Tspyl2 gene therapy retards bleomycin-induced pulmonary fibrosis by modulating downstream TGF-β signaling in mice.
GATA zinc finger protein p66β promotes breast cancer cell migration by acting as a co-activator of Snail.
Depletion of CUL4B in macrophages ameliorates diabetic kidney disease via miR-194-5p/ITGA9 axis.
PLAGL2 promotes Snail expression and gastric cancer progression via UCA1/miR-145-5p/YTHDF1 axis.
Therapeutic Effects of Long-Term Administration of Tranilast in an Animal Model for the Treatment of Fibroids.
Genetic lineage tracing reveals stellate cells as contributors to myofibroblasts in pancreas and islet fibrosis.
Total flavonoid extract from Dracocephalum moldavica L. improves pulmonary fibrosis by reducing inflammation and inhibiting the hedgehog signaling pathway.
Dach1 deficiency drives alveolar epithelium apoptosis in pulmonary fibrosis via modulating C-Jun/Bim activity.
Schwann cells regulate tumor cells and cancer-associated fibroblasts in the pancreatic ductal adenocarcinoma microenvironment.
Metformin attenuates chronic lung allograft dysfunction: evidence in rat models.
CXCL17 Attenuates Diesel Exhaust Emissions Exposure-Induced Lung Damage by Regulating Macrophage Function.
Luteolin inhibits subretinal fibrosis and epithelial-mesenchymal transition in laser-induced mouse model via suppression of Smad2/3 and YAP signaling.
Fibronectin promotes tumor angiogenesis and progression of non-small-cell lung cancer by elevating WISP3 expression via FAK/MAPK/ HIF-1α axis and activating wnt signaling pathway.
Single-cell RNA sequencing reveals that HSD17B2 in cancer-associated fibroblasts promotes the development and progression of castration-resistant prostate cancer.
Tartary buckwheat flavonoids alleviates high-fat diet induced kidney fibrosis in mice by inhibiting MAPK and TGF-β1/Smad signaling pathway.
Quercetin inhibits the amphiregulin/EGFR signaling-mediated renal tubular epithelial-mesenchymal transition and renal fibrosis in obstructive nephropathy.
Poly-γ-glutamic acid coating polymeric nanoparticles enhance renal drug distribution and cellular uptake for diabetic nephropathy therapy.
Interference of ALOX5 alleviates inflammation and fibrosis in high glucose‑induced renal mesangial cells.
The aggravate role of exosomal circRNA11:120406118|12040782 on macrophage pyroptosis through miR-30b-5p/NLRP3 axis in silica-induced lung fibrosis.
Effective-compounds of Jinshui Huanxian formula ameliorates fibroblast activation in pulmonary fibrosis by inhibiting the activation of mTOR signaling.
Telocyte-Derived Exosomes Provide an Important Source of Wnts That Inhibits Fibrosis and Supports Regeneration and Repair of Endometrium.
Baicalin prevents fibrosis of human trabecular meshwork cells via inhibiting the MyD88/NF-κB pathway.
Exosomes derived from human adipose mesenchymal stem cells ameliorate hepatic fibrosis by inhibiting PI3K/Akt/mTOR pathway and remodeling choline metabolism.
The miR-103a-3p/TGFBR3 axis regulates TGF-β-induced orbital fibroblast activation and fibrosis in thyroid-eye disease.
A2aR inhibits fibrosis and the EMT process in silicosis by regulating Wnt/β-catenin pathway.
VX-765 attenuates silica-induced lung inflammatory injury and fibrosis by modulating alveolar macrophages pyroptosis in mice.
Extracellular HSP90 promotes differentiation of lens epithelial cells to fiber cells by activating LRP1-YAP-PROX1 axis.
Fyn deficiency inhibits oxidative stress by decreasing c-Cbl-mediated ubiquitination of Sirt1 to attenuate diabetic renal fibrosis.
BMAL1/p53 mediating bronchial epithelial cell autophagy contributes to PM2.5-aggravated asthma.
Macrophage-derived GPNMB trapped by fibrotic extracellular matrix promotes pulmonary fibrosis.
Mitochondrial dysfunction in macrophages promotes inflammation and suppresses repair after myocardial infarction.
Stomatin-like protein 2 deficiency exacerbates adverse cardiac remodeling.
RGS1 mediates renal interstitial fibrosis through activation of the inflammatory response.
DLK1 overexpression improves sepsis-induced cardiac dysfunction and fibrosis in mice through the TGF-β1/Smad3 signaling pathway and MMPs.
Human umbilical cord mesenchymal stem cell exosomes alleviate acute kidney injury by inhibiting pyroptosis in rats and NRK-52E cells.
LncTUG1 ameliorates renal tubular fibrosis in experimental diabetic nephropathy through the miR-145-5p/dual-specificity phosphatase 6 axis.
LncRNA H19-EZH2 interaction promotes liver fibrosis via reprogramming H3K27me3 profiles.
BMAL1 inhibits renal fibrosis and renal interstitial inflammation by targeting the ERK1/2/ELK-1/Egr-1 axis.
Icariside Ⅱ attenuates bleomycin-induced pulmonary fibrosis by modulating macrophage polarization.
TRIOBP modulates β-catenin signaling by regulation of miR-29b in idiopathic pulmonary fibrosis.
Stromal and tumor immune microenvironment reprogramming through multifunctional cisplatin-based liposomes boosts the efficacy of anti-PD-1 immunotherapy in pancreatic cancer.
Targeting AKT induced Ferroptosis through FTO/YTHDF2-dependent GPX4 m6A methylation up-regulating and degradating in colorectal cancer.
Squalene epoxidase promotes breast cancer progression by regulating CCNB1 protein stability.
Cell and rat serum, urine and tissue metabolomics analysis elucidates the key pathway changes associated with chronic nephropathy and reveals the mechanism of action of rhein.
Aquaporin 1 is a prognostic marker and inhibits tumour progression through downregulation of Snail expression in intrahepatic cholangiocarcinoma.
Testosterone attenuates senile cavernous fibrosis by regulating TGFβR1 and galectin-1 signaling pathways through miR-22-3p.
JMJD3 ablation in myeloid cells confers renoprotection in mice with DOCA/salt-induced hypertension.
Connexin32 Promotes the Activation of Foxo3a to Ameliorate Diabetic Nephropathy via Inhibiting the Polyubiquitination and Degradation of Sirt1.
Neonatal-Tissue-Derived Extracellular Vesicle Therapy (NEXT): A Potent Strategy for Precision Regenerative Medicine.
Crosstalk between Interleukin-1 Receptor-Like 1 and Transforming Growth Factor-β Receptor Signaling Promotes Renal Fibrosis.
USP25 inhibits renal fibrosis by regulating TGFβ-SMAD signaling pathway in Ang II-induced hypertensive mice.
NQO1 alleviates renal fibrosis by inhibiting the TLR4/NF-κB and TGF-β/Smad signaling pathways in diabetic nephropathy.
T Follicular Helper Cells in Tertiary Lymphoid Structure Contribute to Renal Fibrosis by IL-21.
Inhibition of miR-25 Ameliorates Cardiac Dysfunction and Fibrosis by Restoring Krüppel-like Factor 4 Expression.
Biocompatibility and efficacy of prostatic urethral lift in benign prostate hyperplasia: an in vivo and in vitro study.
Knockdown of long noncoding RNA SAN rejuvenates aged adipose-derived stem cells via miR-143-3p/ADD3 axis.
UCP1 alleviates renal interstitial fibrosis progression through oxidative stress pathway mediated by SIRT3 protein stability.
Zanubrutinib Ameliorates Cardiac Fibrosis and Inflammation Induced by Chronic Sympathetic Activation.
UMAD1 contributes to ESCRT-III dynamic subunit turnover during cytokinetic abscission.
Lenvatinib inhibited HCC cell migration and invasion through regulating the transcription and ubiquitination of UHRF1 and DNMT1.
Qianjin Wenwu decoction suppresses renal interstitial fibrosis by enhancing the degradation of extracellular matrix in mice with unilateral ureteral obstruction.
Characterization of myeloid signature genes for predicting prognosis and immune landscape in Ewing sarcoma.
Two-Pore-Domain Potassium Channel TREK-1 Mediates Pulmonary Fibrosis through Macrophage M2 Polarization and by Direct Promotion of Fibroblast Differentiation.
Neural and central mechanisms of kidney fibrosis after relief of ureteral obstruction.
CEBPD is a master transcriptional factor for hypoxia regulated proteins in glioblastoma and augments hypoxia induced invasion through extracellular matrix-integrin mediated EGFR/PI3K pathway.
FGF18 promotes human lung branching morphogenesis through regulating mesenchymal progenitor cells.
Senescent renal tubular epithelial cells activate fibroblasts by secreting Shh to promote the progression of diabetic kidney disease.
Peroxisome Proliferator-Activated Receptor Gene Knockout Promotes Podocyte Injury in Diabetic Mice.
Blockage of Fibronectin 1 Ameliorates Myocardial Ischemia/Reperfusion Injury in Association with Activation of AMP-LKB1-AMPK Signaling Pathway.
Shenxian-Shengmai Oral Liquid Evoke Autophagy of Fibroblast to Attenuate Sinoatrial Node Fibrosis in Sick Sinus Syndrome Mice via the AKT/mTOR Pathway.
Panax Notoginseng Saponins Regulate Transforming Growth Factor-β1 through MAPK and Snail/TWIST1 Signaling Pathway to Inhibit Epithelial-Mesenchymal Transition of Pulmonary Fibrosis in A549 Cells.
Poly (ADP-ribose) polymerase 1 (PARP1) inhibition promotes pulmonary metastasis of osteosarcoma by boosting ezrin phosphorylation.
NR4A1 inhibits the epithelial-mesenchymal transition of hepatic stellate cells: Involvement of TGF-β-Smad2/3/4-ZEB signaling.
Endoglin aggravates peritoneal fibrosis by regulating the activation of TGF-β/ALK/Smads signaling.
Inhibition of calpain9 attenuates peritoneal dialysis-related peritoneal fibrosis.
Yi-Shen-Hua-Shi Granule Alleviates Adriamycin-Induced Glomerular Fibrosis by Suppressing the BMP2/Smad Signaling Pathway.
ATP-citrate lyase inhibitor improves ectopic lipid accumulation in the kidney in a db/db mouse model.
Fraxin Promotes the Activation of Nrf2/ARE Pathway via Increasing the Expression of Connexin43 to Ameliorate Diabetic Renal Fibrosis.
Gentiopicroside Ameliorates Diabetic Renal Tubulointerstitial Fibrosis via Inhibiting the AT1R/CK2/NF-κB Pathway.
Dihydromyricetin Alleviates Pulmonary Fibrosis by Regulating Abnormal Fibroblasts Through the STAT3/p-STAT3/GLUT1 Signaling Pathway.
Atorvastatin Restores PPARα Inhibition of Lipid Metabolism Disorders by Downregulating miR-21 Expression to Improve Mitochondrial Function and Alleviate Diabetic Nephropathy Progression.
Decreased RNA m(6)A methylation enhances the process of the epithelial mesenchymal transition and vasculogenic mimicry in glioblastoma.
Nintedanib enhances the efficacy of PD-L1 blockade by upregulating MHC-I and PD-L1 expression in tumor cells.
Blockade of phosphotyrosine pathways suggesting SH2 superbinder as a novel therapy for pulmonary fibrosis.
Establishment and characterization of an immortalized epithelial cell line from human gallbladder.
Chordin-Like 1 Regulates Epithelial-to-Mesenchymal Transition and Metastasis via the MAPK Signaling Pathway in Oral Squamous Cell Carcinoma.
ATP11A promotes EMT by regulating Numb PRR(L) in pancreatic cancer cells.
Long Noncoding RNA CTD-2589M5.4 Inhibits Ovarian Cancer Cell Proliferation, Migration, and Invasion Via Downregulation of the Extracellular Matrix-Receptor Interaction Pathway.
Imatinib inhibits pericyte-fibroblast transition and inflammation and promotes axon regeneration by blocking the PDGF-BB/PDGFRβ pathway in spinal cord injury.
PKM2 promotes pulmonary fibrosis by stabilizing TGF-β1 receptor I and enhancing TGF-β1 signaling.
miR-124- and let-7-Mediated Reprogram of Human Fibroblasts into SST Interneurons.
RO4929097, a Selective γ-Secretase Inhibitor, Inhibits Subretinal Fibrosis Via Suppressing Notch and ERK1/2 Signaling in Laser-Induced Mouse Model.
The Apelin-APJ axis alleviates LPS-induced pulmonary fibrosis and endothelial mesenchymal transformation in mice by promoting Angiotensin-Converting Enzyme 2.
HC-1119, a deuterated Enzalutamide, inhibits Migration, Invasion and Metastasis of the AR-positive triple-negative breast Cancer cells.
Anti-inflammatory potential of stevia residue extract against uric acid-associated renal injury in mice.
Sestrin2 attenuates renal damage by regulating Hippo pathway in diabetic nephropathy.
A network pharmacology-based study on the mechanism of astragaloside IV alleviating renal fibrosis through the AKT1/GSK-3β pathway.
Molecular Regulation of Heme Oxygenase-1 Expression by E2F Transcription Factor 2 in Lung Fibroblast Cells: Relevance to Idiopathic Pulmonary Fibrosis.
RNF2 mediates pulmonary fibroblasts activation and proliferation by regulating mTOR and p16-CDK4-Rb1 signaling pathway.
Critical role of PAFR/YAP1 positive feedback loop in cardiac fibrosis.
Endophilin A2 protects against renal fibrosis by targeting TGF-β/Smad signaling.
Apigenin inhibits fibrous scar formation after acute spinal cord injury through TGFβ/SMADs signaling pathway.
Si-Wu-Tang ameliorates bile duct ligation-induced liver fibrosis via modulating immune environment.
Lysophosphatidylcholine acyltransferase 1 alleviates silica-induced pulmonary fibrosis by modulating lipid metabolism.
Blockade of the pentraxin 3/CD44 interaction attenuates lung injury-induced fibrosis.
Intracellular hydroxyproline imprinting following resolution of bleomycin-induced pulmonary fibrosis.
Single-Cell RNA Sequencing Technology Revealed the Pivotal Role of Fibroblast Heterogeneity in Angiotensin II-Induced Abdominal Aortic Aneurysms.
Clusterin as a serum biomarker candidate contributes to the lung fibroblasts activation in chronic obstructive pulmonary disease.
Asiatic acid from Cyclocarya paliurus regulates the autophagy-lysosome system via directly inhibiting TGF-β type I receptor and ameliorates diabetic nephropathy fibrosis.
Reversing insufficient photothermal therapy-induced tumor relapse and metastasis by regulating cancer-associated fibroblasts.
Human epididymis protein 4 aggravates airway inflammation and remodeling in chronic obstructive pulmonary disease.
Drug-eluting intraocular lens with sustained bromfenac release for conquering posterior capsular opacification.
Selenium Deficiency Leads to Changes in Renal Fibrosis Marker Proteins and Wnt/β-Catenin Signaling Pathway Components.
Malfunction of airway basal stem cells plays a crucial role in pathophysiology of tracheobronchopathia osteoplastica.
A rapid and simple procedure for the isolation and cultivation of fibroblast-like cells from medaka and zebrafish embryos and fin clip biopsies.
Atorvastatin reduces IOP in ocular hypertension in vivo and suppresses ECM in trabecular meshwork perhaps via FGD4.
Schwann cell‑like cells derived from human amniotic mesenchymal stem cells promote sciatic nerve repair through an exosome‑induced SOX2/FN1 pathway in vitro.
CHIR99021 balance TGFβ1 induced human corneal endothelial-to-mesenchymal transition to favor corneal endothelial cell proliferation.
IL-33 Promotes ST2-Dependent Fibroblast Maturation via P38 and TGF-β in a Mouse Model of Epidural Fibrosis.
Blockade of TMEM16A protects against renal fibrosis by reducing intracellular Cl(-) concentration.
The miRNA-34a/Sirt1/p53 pathway in a rat model of lens regeneration.
Novel Thermosensitive Hydrogel Promotes Spinal Cord Repair by Regulating Mitochondrial Function.
Single-Cell Transcriptomic Analysis of the Mouse Pancreas: Characteristic Features of Pancreatic Ductal Cells in Chronic Pancreatitis.
Systematic analyses identify the anti-fibrotic role of lncRNA TP53TG1 in IPF.
Human amniotic fluid mesenchymal stem cells attenuate pancreatic cancer cell proliferation and tumor growth in an orthotopic xenograft mouse model.
A signature of circadian rhythm genes in driving anaplastic thyroid carcinoma malignant progression.
Gankyrin modulated non-small cell lung cancer progression via glycolysis metabolism in a YAP1-dependent manner.
Reprogramming of Rat Fibroblasts into Induced Neurons by Small-Molecule Compounds In Vitro and In Vivo.
Identification of the active compounds and functional mechanisms of Jinshui Huanxian formula in pulmonary fibrosis by integrating serum pharmacochemistry with network pharmacology.
ZEB2/TWIST1/PRMT5/NuRD Multicomplex Contributes to the Epigenetic Regulation of EMT and Metastasis in Colorectal Carcinoma.
Hexavalent chromium triggers hepatocytes premature senescence via the GATA4/NF-κB signaling pathway mediated by the DNA damage response.
Collagen has a unique SEC24 preference for efficient export from the endoplasmic reticulum.
Doxorubicin promotes breast cancer cell migration and invasion via DCAF13.
AIM2 inflammasome contributes to aldosterone-induced renal injury via endoplasmic reticulum stress.
Identification of Pyruvate Carboxylase as the Cellular Target of Natural Bibenzyls with Potent Anticancer Activity against Hepatocellular Carcinoma via Metabolic Reprogramming.
Overexpression of bone morphogenetic protein receptor type 2 suppresses transforming growth factor β-induced profibrotic responses in lung fibroblasts.
Connexin32 ameliorates epithelial-to-mesenchymal-transition in diabetic renal tubular via inhibiting NOX4.
Norepinephrine promotes glioma cell migration through up-regulating the expression of Twist1.
Numb-PRRL promotes TGF-β1- and EGF-induced epithelial-to-mesenchymal transition in pancreatic cancer.
The HDAC2/SP1/miR-205 feedback loop contributes to tubular epithelial cell extracellular matrix production in diabetic kidney disease.
Necroptosis in pulmonary macrophages promotes silica-induced inflammation and interstitial fibrosis in mice.
Baicalin protects against renal interstitial fibrosis in mice by inhibiting the TGF-β/Smad signalling pathway.
Improving the circulation time and renal therapeutic potency of extracellular vesicles using an endogenous ligand binding strategy.
Carbon dots enhance extracellular matrix secretion for dentin-pulp complex regeneration through PI3K/Akt/mTOR pathway-mediated activation of autophagy.
Astrocyte-derived sEVs alleviate fibrosis and promote functional recovery after spinal cord injury in rats.
Zanubrutinib attenuates bleomycin-induced pulmonary fibrosis by inhibiting the TGF-β1 signaling pathway.
TIPARP is involved in the regulation of intraocular pressure.
Metformin Improves Burn Wound Healing by Modulating Microenvironmental Fibroblasts and Macrophages.
Macrophages regulate vascular smooth muscle cell function during atherosclerosis progression through IL-1β/STAT3 signaling.
Tetramethylpyrazine prevents liver fibrotic injury in mice by targeting hepatocyte-derived and mitochondrial DNA-enriched extracellular vesicles.
Ferrostatin‑1 alleviates oxalate‑induced renal tubular epithelial cell injury, fibrosis and calcium oxalate stone formation by inhibiting ferroptosis.
Krill Oil Turns Off TGF-β1 Profibrotic Signaling in the Prevention of Diabetic Nephropathy.
Tubular epithelial cell-derived extracellular vesicles induce macrophage glycolysis by stabilizing HIF-1α in diabetic kidney disease.
Comparison of Gene Expression Patterns in Articular Cartilage and Xiphoid Cartilage.
Inhibition of RUNX1 blocks the differentiation of lung fibroblasts to myofibroblasts.
Botox-A improve the thyroid-associated ophthalmopathy (TAO) orbital fibroblast activation through inhibiting the TGF-β/Smad signaling.
Exosomes from human adipose-derived mesenchymal stem cells inhibit production of extracellular matrix in keloid fibroblasts via downregulating transforming growth factor-β2 and Notch-1 expression.
Cigarette smoke-induced oxidative stress activates NRF2 to mediate fibronectin disorganization in vascular formation.
SU16f inhibits fibrotic scar formation and facilitates axon regeneration and locomotor function recovery after spinal cord injury by blocking the PDGFRβ pathway.
Hexachlorophene, a selective SHP2 inhibitor, suppresses proliferation and metastasis of KRAS-mutant NSCLC cells by inhibiting RAS/MEK/ERK and PI3K/AKT signaling pathways.
Integrin β3 Induction Promotes Tubular Cell Senescence and Kidney Fibrosis.
Mesenchymal Stem Cells With Cancer-Associated Fibroblast-Like Phenotype Stimulate SDF-1/CXCR4 Axis to Enhance the Growth and Invasion of B-Cell Acute Lymphoblastic Leukemia Cells Through Cell-to-Cell Communication.
Mechanically Activated Calcium Channel PIEZO1 Modulates Radiation-Induced Epithelial-Mesenchymal Transition by Forming a Positive Feedback With TGF-β1.
Tubular cell-derived exosomal miR-150-5p contributes to renal fibrosis following unilateral ischemia-reperfusion injury by activating fibroblast in vitro and in vivo.
NEDD4L-induced β-catenin ubiquitination suppresses the formation and progression of interstitial pulmonary fibrosis via inhibiting the CTHRC1/HIF-1α axis.
Sympathetic Denervation Ameliorates Renal Fibrosis via Inhibition of Cellular Senescence.
Ferulic Acid Ameliorates Hepatic Inflammation and Fibrotic Liver Injury by Inhibiting PTP1B Activity and Subsequent Promoting AMPK Phosphorylation.
The Extracellular Matrix Enriched With Exosomes for the Treatment on Pulmonary Fibrosis in Mice.
Transcriptome-Based Network Analysis Reveals Hirudin Potentiates Anti-Renal Fibrosis Efficacy in UUO Rats.
Berberine Reduces Lipid Accumulation by Promoting Fatty Acid Oxidation in Renal Tubular Epithelial Cells of the Diabetic Kidney.
Mefunidone Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Mice.
Binding of Plasminogen to Streptococcus suis Protein Endopeptidase O Facilitates Evasion of Innate Immunity in Streptococcus suis.
ShenLian Extract Enhances TGF-β Functions in the Macrophage-SMC Unit and Stabilizes Atherosclerotic Plaques.
Ameliorative Effects of Osthole on Experimental Renal Fibrosis in vivo and in vitro by Inhibiting IL-11/ERK1/2 Signaling.
Exosomal miR-500a-5p derived from cancer-associated fibroblasts promotes breast cancer cell proliferation and metastasis through targeting USP28.
Exosomal miR-21 from tubular cells contributes to renal fibrosis by activating fibroblasts via targeting PTEN in obstructed kidneys.
Local administration of liposomal-based Srpx2 gene therapy reverses pulmonary fibrosis by blockading fibroblast-to-myofibroblast transition.
The NEAT1_2/miR-491 Axis Modulates Papillary Thyroid Cancer Invasion and Metastasis Through TGM2/NFκb/FN1 Signaling.
miR-23a-3p regulates the inflammatory response and fibrosis in diabetic kidney disease by targeting early growth response 1.
Use of Platelet-Rich Plasma Plus Suramin, an Antifibrotic Agent, to Improve Muscle Healing After Injuries.
Exercise training ameliorates early diabetic kidney injury by regulating the H(2) S/SIRT1/p53 pathway.
Presegetane diterpenoids from Euphorbia sieboldiana as a new type of anti-liver fibrosis agents that inhibit TGF-β/Smad signaling pathway.
MiR-192-5p inhibits proliferation, migration, and invasion in papillary thyroid carcinoma cells by regulation of SH3RF3.
KLF15 negatively regulates cardiac fibrosis by which SDF-1β attenuates cardiac fibrosis in type 2 diabetic mice.
MIER3 induces epithelial-mesenchymal transition and promotes breast cancer cell aggressiveness via forming a co-repressor complex with HDAC1/HDAC2/Snail.
A novel in vitro assay for peripheral nerve-related cell migration that preserves both extracellular matrix-derived molecular cues and nanofiber-derived topography.
Interleukin-7 Is Associated with Clinical and Pathological Activities in Immunoglobulin A Nephropathy and Protects the Renal Proximal Tubule Epithelium from Cellular Fibrosis.
The long non-coding RNA PFI protects against pulmonary fibrosis by interacting with splicing regulator SRSF1.
Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors.
Triiodothyronine ameliorates silica-induced pulmonary inflammation and fibrosis in mice.
Maiwei Yangfei decoction prevents bleomycin-induced pulmonary fibrosis in mice.
Injectable self-assembling peptide nanofiber hydrogel as a bioactive 3D platform to promote chronic wound tissue regeneration.
Si-Wu-Tang ameliorates fibrotic liver injury via modulating intestinal microbiota and bile acid homeostasis.
Drug-containing serum of rhubarb-astragalus capsule inhibits the epithelial-mesenchymal transformation of HK-2 by downregulating TGF-β1/p38MAPK/Smad2/3 pathway.
MPP7 promotes the migration and invasion of breast cancer cells via EGFR/AKT signaling.
Fibronectin-integrin signaling regulates PLVAP localization at endothelial fenestrae by microtubule stabilization.
miR-509-3p Suppresses Migration, Invasion, and Epithelial- Mesenchymal Transition in Melanoma Cells by Targeting Collagen Triple Helix Repeat Containing 1.
Improved response of human gingival fibroblasts to titanium coated with micro-/nano-structured tantalum.
A HIF1A/miR-485-5p/SRPK1 axis modulates the aggressiveness of glioma cells upon hypoxia.
Glucagon-like peptide-1 (GLP-1) improved diabetic lung fibrosis via AMPK and microRNA-27a (miR-27a).
Dopamine receptor D2 inhibition alleviates diabetic hepatic stellate cells fibrosis by regulating the TGF-β1/Smads and NFκB pathways.
miR‑106b‑5p targeting SIX1 inhibits TGF‑β1‑induced pulmonary fibrosis and epithelial‑mesenchymal transition in asthma through regulation of E2F1.
KLF4 initiates sustained YAP activation to promote renal fibrosis in mice after ischemia-reperfusion kidney injury.
Aptamer-SH2 superbinder-based targeted therapy for pancreatic ductal adenocarcinoma.
pH-Sensitive Nanoparticles Composed Solely of Membrane-Disruptive Macromolecules for Treating Pancreatic Cancer.
The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity.
Identification and functional analysis of senescence-associated secretory phenotype of premature senescent hepatocytes induced by hexavalent chromium.
Regulation of connective tissue growth factor expression by miR-133b for the treatment of renal interstitial fibrosis in aged mice with unilateral ureteral obstruction.
Inhibition of ER stress by targeting the IRE1α-TXNDC5 pathway alleviates crystalline silica-induced pulmonary fibrosis.
USP9X deubiquitinates connexin43 to prevent high glucose-induced epithelial-to-mesenchymal transition in NRK-52E cells.
STAT3/HIF-1α signaling activation mediates peritoneal fibrosis induced by high glucose.
Mesenchymal stem cells ameliorate silica-induced pulmonary fibrosis by inhibition of inflammation and epithelial-mesenchymal transition.
A Novel Rat Model with Long Range Optic Nerve Injury to Study Retinal Ganglion Cells Endogenous Regeneration.
LncRNA CTD-2528L19.6 prevents the progression of IPF by alleviating fibroblast activation.
Pterostilbene alleviates pulmonary fibrosis by regulating ASIC2.
GALNT2 promotes cell proliferation, migration, and invasion by activating the Notch/Hes1-PTEN-PI3K/Akt signaling pathway in lung adenocarcinoma.
Physcion 8-O-β-glucopyranoside ameliorates liver fibrosis through inflammation inhibition by regulating SIRT3-mediated NF-κB P65 nuclear expression.
Long noncoding RNA EPB41L4A-AS1 functions as an oncogene by regulating the Rho/ROCK pathway in colorectal cancer.
Treatment of keloids through Runx2 siRNA‑induced inhibition of the PI3K/AKT signaling pathway.
Mitomycin C induces pulmonary vascular endothelial-to-mesenchymal transition and pulmonary veno-occlusive disease via Smad3-dependent pathway in rats.
Responsive and activable nanomedicines for remodeling the tumor microenvironment.
Anti-renal interstitial fibrosis effect of norcantharidin is exerted through inhibition of PP2Ac-mediated C-terminal phosphorylation of Smad3.
Involvement of miR-27a-3p in diabetic nephropathy via affecting renal fibrosis, mitochondrial dysfunction, and endoplasmic reticulum stress.
Epigallocatechin gallate (EGCG) attenuates myocardial hypertrophy and fibrosis induced by transverse aortic constriction via inhibiting the Akt/mTOR pathway.
Exosomal ANXA2 derived from ovarian cancer cells regulates epithelial-mesenchymal plasticity of human peritoneal mesothelial cells.
Tissue factor potentiates adherence of breast cancer cells to human umbilical vein endothelial cells under static and flow conditions.
Withaferin A protects against hyperuricemia induced kidney injury and its possible mechanisms.
Deficiency of CARMA3 attenuates the development of bleomycin induced pulmonary fibrosis.
Effects of L-leucine on the properties of spray-dried swellable microparticles with wrinkled surfaces for inhalation therapy of pulmonary fibrosis.
Heat shock protein 90 inhibitor ameliorates pancreatic fibrosis by degradation of transforming growth factor-β receptor.
LncRNA-MALAT1/miRNA-204-5p/Smad4 Axis Regulates Epithelial-Mesenchymal Transition, Proliferation and Migration of Lens Epithelial Cells.
IL-1β augments TGF-β inducing epithelial-mesenchymal transition of epithelial cells and associates with poor pulmonary function improvement in neutrophilic asthmatics.
Adenosine A3 receptor activated in H(2)O(2) oxidative stress of primary open-angle glaucoma.
Metformin attenuates post-epidural fibrosis by inhibiting the TGF-β1/Smad3 and HMGB1/TLR4 signaling pathways.
Astragalus membranaceus and Salvia miltiorrhiza ameliorates cyclosporin A-induced chronic nephrotoxicity through the "gut-kidney axis".
Metformin effectively treats Tsc1 deletion-caused kidney pathology by upregulating AMPK phosphorylation.
IL-33-induced neutrophil extracellular traps degrade fibronectin in a murine model of bronchopulmonary dysplasia.
Transcriptomic Analysis Reveals the Protection of Astragaloside IV against Diabetic Nephropathy by Modulating Inflammation.
Hirudin Ameliorates Renal Interstitial Fibrosis via Regulating TGF-β1/Smad and NF-κB Signaling in UUO Rat Model.
Withaferin A Exerts Preventive Effect on Liver Fibrosis through Oxidative Stress Inhibition in a Sirtuin 3-Dependent Manner.
Empagliflozin Protects Against Proximal Renal Tubular Cell Injury Induced by High Glucose via Regulation of Hypoxia-Inducible Factor 1-Alpha.
Melatonin ameliorates hyperglycaemia-induced renal inflammation by inhibiting the activation of TLR4 and TGF-β1/Smad3 signalling pathway.
Hyperoside Attenuates Bleomycin-Induced Pulmonary Fibrosis Development in Mice.
Scutellarein inhibits BLM-mediated pulmonary fibrosis by affecting fibroblast differentiation, proliferation, and apoptosis.
Epithelial-Mesenchymal Transition in Asthma Airway Remodeling Is Regulated by the IL-33/CD146 Axis.
Andrographolide attenuates epithelial-mesenchymal transition induced by TGF-β1 in alveolar epithelial cells.
Deubiquitinase USP13 promotes extracellular matrix expression by stabilizing Smad4 in lung fibroblast cells.
High-mobility group box 1 promotes epithelial-to-mesenchymal transition in crystalline silica induced pulmonary inflammation and fibrosis.
The AKT/GSK3-Mediated Slug Expression Contributes to Oxaliplatin Resistance in Colorectal Cancer via Upregulation of ERCC1.
Deubiquitinase USP29 promotes gastric cancer cell migration by cooperating with phosphatase SCP1 to stabilize Snail protein.
Neutrophil extracellular traps promote scar formation in post-epidural fibrosis.
MAD2B contributes to parietal epithelial cell activation and crescentic glomerulonephritis via Skp2.
MiR-185-5p ameliorates endoplasmic reticulum stress and renal fibrosis by downregulation of ATF6.
Sox13 promotes hepatocellular carcinoma metastasis by transcriptionally activating Twist1.
TREM2 Alzheimer's variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages.
Norcantharidin protects against renal interstitial fibrosis by suppressing TWEAK-mediated Smad3 phosphorylation.
Ganoderic acid hinders renal fibrosis via suppressing the TGF-β/Smad and MAPK signaling pathways.
Inhibition of miR-182-5p attenuates pulmonary fibrosis via TGF-β/Smad pathway.
Ischemia-reperfusion injury of brain induces endothelial-mesenchymal transition and vascular fibrosis via activating let-7i/TGF-βR1 double-negative feedback loop.
Cardamonin retards progression of autosomal dominant polycystic kidney disease via inhibiting renal cyst growth and interstitial fibrosis.
Renoprotective Effect of a Dipeptidyl Peptidase-4 Inhibitor on Aging Mice.
IRF-1 promotes renal fibrosis by downregulation of Klotho.
WNT1-inducible signaling protein-1 mediates TGF-β1-induced renal fibrosis in tubular epithelial cells and unilateral ureteral obstruction mouse models via autophagy.
Olfactory ensheathing cells facilitate neurite sprouting and outgrowth by secreting high levels of hevin.
A PTAL-miR-101-FN1 Axis Promotes EMT and Invasion-Metastasis in Serous Ovarian Cancer.
Tartrate-Resistant Acid Phosphatase 5/ACP5 Interacts with p53 to Control the Expression of SMAD3 in Lung Adenocarcinoma.
Monocyte-derived alveolar macrophage apolipoprotein E participates in pulmonary fibrosis resolution.
Antisense Oligonucleotide in LNA-Gapmer Design Targeting TGFBR2-A Key Single Gene Target for Safe and Effective Inhibition of TGFβ Signaling.
Long non-coding RNA DBH-AS1 promotes cancer progression in diffuse large B-cell lymphoma by targeting FN1 via RNA-binding protein BUD13.
HMGB1 protein promotes glomerular mesangial matrix deposition via TLR2 in lupus nephritis.
RhoJ Regulates α5β1 Integrin Trafficking to Control Fibronectin Remodeling during Angiogenesis.
Transcriptomic analysis of the mechanisms of alleviating renal interstitial fibrosis using the traditional Chinese medicine Kangxianling in a rat model.
Klotho is regulated by transcription factor Sp1 in renal tubular epithelial cells.
Modification of PLGA Scaffold by MSC-Derived Extracellular Matrix Combats Macrophage Inflammation to Initiate Bone Regeneration via TGF-β-Induced Protein.
LRIG3 represses cell motility by inhibiting slug via inactivating ERK signaling in human colorectal cancer.
The effect of lncRNA-ARAP1-AS2/ARAP1 on high glucose-induced cytoskeleton rearrangement and epithelial-mesenchymal transition in human renal tubular epithelial cells.
Connexin 43 prevents the progression of diabetic renal tubulointerstitial fibrosis by regulating the SIRT1-HIF-1α signaling pathway.
Type I collagen facilitates safe and reliable expansion of human dental pulp stem cells in xenogeneic serum-free culture.
Phloretin ameliorates hyperuricemia-induced chronic renal dysfunction through inhibiting NLRP3 inflammasome and uric acid reabsorption.
miRNA‑342 suppresses renal interstitial fibrosis in diabetic nephropathy by targeting SOX6.
Subcellular trafficking of tubular MDM2 implicates in acute kidney injury to chronic kidney disease transition during multiple low-dose cisplatin exposure.
Hydrogen sulfide attenuates cigarette smoke-induced airway remodeling by upregulating SIRT1 signaling pathway.
Celastrol exerts anti-inflammatory effect in liver fibrosis via activation of AMPK-SIRT3 signalling.
Connexin32 ameliorates renal fibrosis in diabetic mice by promoting K48-linked NADPH oxidase 4 polyubiquitination and degradation.
Gentiopicroside activates the bile acid receptor Gpbar1 (TGR5) to repress NF-kappaB pathway and ameliorate diabetic nephropathy.
Long non-coding RNA RNF7 promotes the cardiac fibrosis in rat model via miR-543/THBS1 axis and TGFβ1 activation.
GSPE alleviates renal fibrosis by inhibiting the activation of C3/ HMGB1/ TGF-β1 pathway.
miR-485 suppresses inflammation and proliferation of mesangial cells in an in vitro model of diabetic nephropathy by targeting NOX5.
Fibroblasts Derived From Human Adipose Stem Cells Produce More Effective Extracellular Matrix and Migrate Faster Compared to Primary Dermal Fibroblasts.
miR-363-3p inhibits migration, invasion, and epithelial-mesenchymal transition by targeting NEDD9 and SOX4 in non-small-cell lung cancer.
Anti-Adhesive, Platelet Gathering Effects of c-RGD Modified Poly(p-dioxanone-co-l-Phe) Electrospun Membrane and Its Comprehensive Application in Intestinal Anastomosis.
A self-assembling peptide hydrogel-based drug co-delivery platform to improve tissue repair after ischemia-reperfusion injury.
IL-6 trans-signaling drives a STAT3-dependent pathway that leads to structural alterations of the peritoneal membrane.
Polydatin attenuates renal fibrosis in diabetic mice through regulating the Cx32-Nox4 signaling pathway.
Disruption of retinoid homeostasis induces RBP4 overproduction in diabetes: O-GlcNAcylation involved.
Stem-cell-derived ECM sheet-implant complexes for enhancing osseointegration.
Regulation of FN1 degradation by the p62/SQSTM1-dependent autophagy-lysosome pathway in HNSCC.
Transcriptome analysis reveals a protective role of liver X receptor alpha against silica particle-induced experimental silicosis.
Metformin inhibits extracellular matrix accumulation, inflammation and proliferation of mesangial cells in diabetic nephropathy by regulating H19/miR-143-3p/TGF-β1 axis.
Melatonin Ameliorates Renal Fibrosis Through the Inhibition of NF-κB and TGF-β1/Smad3 Pathways in db/db Diabetic Mice.
Possible involvement of TGF‑β‑SMAD‑mediated epithelial‑mesenchymal transition in pro‑metastatic property of PAX6.
miR-143 inhibits renal cell carcinoma cells metastatic potential by suppressing ABL2.
Hsa-miR-425-5p promotes tumor growth and metastasis by activating the CTNND1-mediated β-catenin pathway and EMT in colorectal cancer.
Trichostatin A Alleviates Renal Interstitial Fibrosis Through Modulation of the M2 Macrophage Subpopulation.
RIG-I aggravates interstitial fibrosis via c-Myc-mediated fibroblast activation in UUO mice.
LncRNA LINP1 confers tamoxifen resistance and negatively regulated by ER signaling in breast cancer.
Micro-vesicles from mesenchymal stem cells over-expressing miR-34a inhibit transforming growth factor-β1-induced epithelial-mesenchymal transition in renal tubular epithelial cells in vitro.
Wu-Mei-Wan ameliorates chronic colitis-associated intestinal fibrosis through inhibiting fibroblast activation.
MicroRNA-183 regulates lipopolysaccharide-induced oxidative stress of hippocampal neurons by targeting the fibronectin 1 gene.
Exosomal miR-125a-5p derived from silica-exposed macrophages induces fibroblast transdifferentiation.
Kidney-targeted rhein-loaded liponanoparticles for diabetic nephropathy therapy via size control and enhancement of renal cellular uptake.
FOXO1 Overexpression Attenuates Tubulointerstitial Fibrosis and Apoptosis in Diabetic Kidneys by Ameliorating Oxidative Injury via TXNIP-TRX.
Stem Cells from Human Exfoliated Deciduous Teeth Ameliorate Diabetic Nephropathy In Vivo and In Vitro by Inhibiting Advanced Glycation End Product-Activated Epithelial-Mesenchymal Transition.
TGF-β1 Induces Epithelial-Mesenchymal Transition of Chronic Sinusitis with Nasal Polyps through MicroRNA-21.
Presence and function of stress granules in atrial fibrillation.
Development and validation of a novel phonomimetic bioreactor.
CLK3 Is A Direct Target Of miR-144 And Contributes To Aggressive Progression In Hepatocellular Carcinoma.
Ursolic Acid Treatment Alleviates Diabetic Kidney Injury By Regulating The ARAP1/AT1R Signaling Pathway.
A small molecule inhibitor MCC950 ameliorates kidney injury in diabetic nephropathy by inhibiting NLRP3 inflammasome activation.
Low-molecular-weight fucoidan attenuates bleomycin-induced pulmonary fibrosis: possible role in inhibiting TGF-β1-induced epithelial-mesenchymal transition through ERK pathway.
Dapagliflozin Attenuates Renal Tubulointerstitial Fibrosis Associated With Type 1 Diabetes by Regulating STAT1/TGFβ1 Signaling.
lncRNA NR_038323 Suppresses Renal Fibrosis in Diabetic Nephropathy by Targeting the miR-324-3p/DUSP1 Axis.
Germacrane Sesquiterpenoids as a New Type of Anticardiac Fibrosis Agent Targeting Transforming Growth Factor β Type I Receptor.
Plasma fractalkine levels are associated with renal inflammation and outcomes in immunoglobulin A nephropathy.
Pioglitazone attenuates kidney fibrosis via miR-21-5p modulation.
Potential role of M2 macrophage polarization in ventilator-induced lung fibrosis.
FoxO1-mediated inhibition of STAT1 alleviates tubulointerstitial fibrosis and tubule apoptosis in diabetic kidney disease.
TNF-α Regulates ITGβ1 and SYND4 Expression in Nucleus Pulposus Cells: Activation of FAK/PI3K Signaling.
RNA-Seq analysis of potential lncRNAs and genes for the anti-renal fibrotic effect of norcantharidin.
Rhodojaponin II attenuates kidney injury by regulating TGF-β1/Smad pathway in mice with adriamycin nephropathy.
NLRP3 inflammasome inhibition attenuates cisplatin-induced renal fibrosis by decreasing oxidative stress and inflammation.
Genetic loss of Gas6/Mer pathway attenuates silica-induced lung inflammation and fibrosis in mice.
Role of CCR2 in the Development of Streptozotocin-Treated Diabetic Cardiomyopathy.
G9a and histone deacetylases are crucial for Snail2-mediated E-cadherin repression and metastasis in hepatocellular carcinoma.
ROCK2 Confers Acquired Gemcitabine Resistance in Pancreatic Cancer Cells by Upregulating Transcription Factor ZEB1.
HIC-5 in cancer-associated fibroblasts contributes to esophageal squamous cell carcinoma progression.
SREBP1, targeted by miR-18a-5p, modulates epithelial-mesenchymal transition in breast cancer via forming a co-repressor complex with Snail and HDAC1/2.
MicroRNA-34a Promotes Renal Fibrosis by Downregulation of Klotho in Tubular Epithelial Cells.
Inhibition of lymphatic proliferation by the selective VEGFR-3 inhibitor SAR131675 ameliorates diabetic nephropathy in db/db mice.
Intervertebral disc regeneration with an adipose mesenchymal stem cell-derived tissue-engineered construct in a rat nucleotomy model.
Ribes diacanthum Pall (RDP) ameliorates UUO-induced renal fibrosis via both canonical and non-canonical TGF-β signaling pathways in mice.
Three kinds of corneal host cells contribute differently to corneal neovascularization.
EZH2-DNMT1-mediated epigenetic silencing of miR-142-3p promotes metastasis through targeting ZEB2 in nasopharyngeal carcinoma.
RNF128 Promotes Invasion and Metastasis Via the EGFR/MAPK/MMP-2 Pathway in Esophageal Squamous Cell Carcinoma.
Role of PM(2.5) in the development and progression of COPD and its mechanisms.
Aspirin inhibits inflammation and scar formation in the injury tendon healing through regulating JNK/STAT-3 signalling pathway.
LncRNA PFAR contributes to fibrogenesis in lung fibroblasts through competitively binding to miR-15a.
Sphingosine kinase 1 promotes the metastasis of colorectal cancer by inducing the epithelial‑mesenchymal transition mediated by the FAK/AKT/MMPs axis.
Loss of TMEM126A promotes extracellular matrix remodeling, epithelial-to-mesenchymal transition, and breast cancer metastasis by regulating mitochondrial retrograde signaling.
miR-196a-5p promotes metastasis of colorectal cancer via targeting IκBα.
Tinagl1 Suppresses Triple-Negative Breast Cancer Progression and Metastasis by Simultaneously Inhibiting Integrin/FAK and EGFR Signaling.
Protein kinase C inhibitor chelerythrine attenuates partial unilateral ureteral obstruction induced kidney injury in neonatal rats.
An improved cellular enucleation method with extracellular matrix and colchicine facilitates the study of nucleocytoplasmic interaction.
Snail2 induced E-cadherin suppression and metastasis in lung carcinoma facilitated by G9a and HDACs.
Injectable extracellular vesicle-released self-assembling peptide nanofiber hydrogel as an enhanced cell-free therapy for tissue regeneration.
Functional significance of U2AF1 S34F mutations in lung adenocarcinomas.
MicroRNA-432 is downregulated in cervical cancer and directly targets FN1 to inhibit cell proliferation and invasion.
TGF-β-mediated upregulation of brachyury contributes to constitutively up-regulated type I collagen expression in skin fibroblasts: possible role in systemic sclerosis.
Astaxanthin ameliorates renal interstitial fibrosis and peritubular capillary rarefaction in unilateral ureteral obstruction.
Effects of SIRT1 silencing on viability, invasion and metastasis of human glioma cell lines.
Citrus alkaline extracts prevent fibroblast senescence to ameliorate pulmonary fibrosis via activation of COX-2.
LncRNA PFL contributes to cardiac fibrosis by acting as a competing endogenous RNA of let-7d.
Inhibition of SIRT2 Alleviates Fibroblast Activation and Renal Tubulointerstitial Fibrosis via MDM2.
Kindlin-2 regulates hepatic stellate cells activation and liver fibrogenesis.
Cyclin G2 Suppresses Glomerulosclerosis by Regulating Canonical Wnt Signalling.
Kidney-targeted drug delivery via rhein-loaded polyethyleneglycol-co-polycaprolactone-co-polyethylenimine nanoparticles for diabetic nephropathy therapy.
Wenyang Huazhuo Tongluo formula inhibits fibrosis via suppressing Wnt/β-catenin signaling pathway in a Bleomycin-induced systemic sclerosis mouse model.
Renal-protective effect of thalidomide in streptozotocin-induced diabetic rats through anti-inflammatory pathway.
LncRNA UCA1 sponges miR-204-5p to promote migration, invasion and epithelial-mesenchymal transition of glioma cells via upregulation of ZEB1.
A novel bioscaffold with naturally-occurring extracellular matrix promotes hepatocyte survival and vessel patency in mouse models of heterologous transplantation.
lncRNA PFAR Promotes Lung Fibroblast Activation and Fibrosis by Targeting miR-138 to Regulate the YAP1-Twist Axis.
S3I-201 ameliorates tubulointerstitial lesion of the kidneys in MRL/lpr mice.
NMDA receptor activation inhibits the antifibrotic effect of BM-MSCs on bleomycin-induced pulmonary fibrosis.
lncRNA PFAL promotes lung fibrosis through CTGF by competitively binding miR-18a.
Inhibition of lncRNA PFRL prevents pulmonary fibrosis by disrupting the miR-26a/smad2 loop.
The pro-metastasis effect of circANKS1B in breast cancer.
Effects of Resveratrol on the Renin-Angiotensin System in the Aging Kidney.
Towards an in vitro fibrogenesis model of human vocal fold scarring.
Methanol fixed fibroblasts serve as feeder cells to maintain stem cells in the pluripotent state in vitro.
Rotenone ameliorates chronic renal injury caused by acute ischemia/reperfusion.
Fibronectin Facilitates Enterovirus 71 Infection by Mediating Viral Entry.
LincRNA 1700020I14Rik alleviates cell proliferation and fibrosis in diabetic nephropathy via miR-34a-5p/Sirt1/HIF-1α signaling.
The protective effect of resveratrol on vascular aging by modulation of the renin-angiotensin system.
RhoA/Rho-kinase triggers epithelial-mesenchymal transition in mesothelial cells and contributes to the pathogenesis of dialysis-related peritoneal fibrosis.
Autophagy inhibition attenuates the induction of anti-inflammatory effect of catalpol in liver fibrosis.
Administration of cytokine-induced myeloid-derived suppressor cells ameliorates renal fibrosis in diabetic mice.
Stachydrine ameliorates carbon tetrachloride-induced hepatic fibrosis by inhibiting inflammation, oxidative stress and regulating MMPs/TIMPs system in rats.
β-Arrestin-1 deficiency ameliorates renal interstitial fibrosis by blocking Wnt1/β-catenin signaling in mice.
Aucubin Protects against TGFβ1-Induced Cardiac Fibroblasts Activation by Mediating the AMPKα/mTOR Signaling Pathway.
Regulation of pancreatic stellate cell activation by Notch3.
PLZF inhibits proliferation and metastasis of gallbladder cancer by regulating IFIT2.
SIRT3 prevents angiotensin II-induced renal tubular epithelial-mesenchymal transition by ameliorating oxidative stress and mitochondrial dysfunction.
Salvianolic acid B inhibits myofibroblast transdifferentiation in experimental pulmonary fibrosis via the up-regulation of Nrf2.
Nicotine Induces Progressive Properties of Lung Adenocarcinoma A549 Cells by Inhibiting Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Expression and Plasma Membrane Localization.
Autophagy promotes fibrosis and apoptosis in the peritoneum during long-term peritoneal dialysis.
Ursolic Acid Attenuates High Glucose-Mediated Mesangial Cell Injury by Inhibiting the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR) Signaling Pathway.
A cell culture condition that induces the mesenchymal-epithelial transition of dedifferentiated porcine retinal pigment epithelial cells.
CAPE-pNO(2) attenuates diabetic cardiomyopathy through the NOX4/NF-κB pathway in STZ-induced diabetic mice.
Binding of a glaucoma-associated myocilin variant to the αB-crystallin chaperone impedes protein clearance in trabecular meshwork cells.
Tamoxifen attenuates dialysate-induced peritoneal fibrosis by inhibiting GSK-3β/β-catenin axis activation.
Epigenetic suppression of E-cadherin expression by Snail2 during the metastasis of colorectal cancer.
RGC-32 regulates reactive astrocytosis and extracellular matrix deposition in experimental autoimmune encephalomyelitis.
Upregulation of allograft inflammatory factor‑1 expression and secretion by macrophages stimulated with aldosterone promotes renal fibroblasts to a profibrotic phenotype.
SNAI1, an endothelial-mesenchymal transition transcription factor, promotes the early phase of ocular neovascularization.
Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem.
LncRNA PTAR promotes EMT and invasion-metastasis in serous ovarian cancer by competitively binding miR-101-3p to regulate ZEB1 expression.
Melatonin Protects against Lung Fibrosis by Regulating the Hippo/YAP Pathway.
Novel decellularized liver matrix-alginate hybrid gel beads for the 3D culture of hepatocellular carcinoma cells.
Saxagliptin Attenuates Albuminuria by Inhibiting Podocyte Epithelial- to-Mesenchymal Transition via SDF-1α in Diabetic Nephropathy.
The TGF-β System As a Potential Pathogenic Player in Disease Modulation of Amyotrophic Lateral Sclerosis.
Dioscin, a potent ITGA5 inhibitor, reduces the synthesis of collagen against liver fibrosis: Insights from SILAC-based proteomics analysis.
Pancreatic cancer-derived exosomes promote tumor metastasis and liver pre-metastatic niche formation.
MDM2 Contributes to High Glucose-Induced Glomerular Mesangial Cell Proliferation and Extracellular Matrix Accumulation via Notch1.
FZD7 is a novel prognostic marker and promotes tumor metastasis via WNT and EMT signaling pathways in esophageal squamous cell carcinoma.
Calreticulin promotes EGF-induced EMT in pancreatic cancer cells via Integrin/EGFR-ERK/MAPK signaling pathway.
ANGPTL1 Interacts with Integrin α1β1 to Suppress HCC Angiogenesis and Metastasis by Inhibiting JAK2/STAT3 Signaling.
Losartan Attenuates Scar Formation in Filtering Bleb After Trabeculectomy.
Evodiamine attenuates TGF-β1-induced fibroblast activation and endothelial to mesenchymal transition.
miR-206 inhibits FN1 expression and proliferation and promotes apoptosis of rat type II alveolar epithelial cells.
NUBPL, a novel metastasis-related gene, promotes colorectal carcinoma cell motility by inducing epithelial-mesenchymal transition.
TGFβ-incurred epigenetic aberrations of miRNA and DNA methyltransferase suppress Klotho and potentiate renal fibrosis.
Glucose variability aggravates cardiac fibrosis by altering AKT signalling path.
Autophagy plays a role in FSTL1-induced epithelial mesenchymal transition and airway remodeling in asthma.
Rhein reverses Klotho repression via promoter demethylation and protects against kidney and bone injuries in mice with chronic kidney disease.
Phosphoinositide 3-kinase/protein kinase B/periostin mediated platelet-derived growth factor-induced cell proliferation and extracellular matrix production in lupus nephritis.
5-Aza-2'-deoxycytidine induces human Tenon's capsule fibroblasts differentiation and fibrosis by up-regulating TGF-β type I receptor.
MicroRNA-139 targets fibronectin 1 to inhibit papillary thyroid carcinoma progression.
Low molecular weight fucoidan and its fractions inhibit renal epithelial mesenchymal transition induced by TGF-β1 or FGF-2.
CAPE-pNO(2) ameliorated diabetic nephropathy through regulating the Akt/NF-κB/ iNOS pathway in STZ-induced diabetic mice.
Triptolide Restores Autophagy to Alleviate Diabetic Renal Fibrosis through the miR-141-3p/PTEN/Akt/mTOR Pathway.
Sesamin prevents apoptosis and inflammation after experimental myocardial infarction by JNK and NF-κB pathways.
MDM2 mediates fibroblast activation and renal tubulointerstitial fibrosis via a p53-independent pathway.
Naringenin Ameliorated Kidney Injury through Let-7a/TGFBR1 Signaling in Diabetic Nephropathy.
Age-Associated Changes in the Vascular Renin-Angiotensin System in Mice.
Quantitative Proteomic Profiling the Molecular Signatures of Annexin A5 in Lung Squamous Carcinoma Cells.
Hepatitis B Virus Stimulated Fibronectin Facilitates Viral Maintenance and Replication through Two Distinct Mechanisms.
Emodin ameliorates bleomycin-induced pulmonary fibrosis in rats by suppressing epithelial-mesenchymal transition and fibroblast activation.
MAD2B promotes tubular epithelial-to-mesenchymal transition and renal tubulointerstitial fibrosis via Skp2.
Emodin alleviates bleomycin-induced pulmonary fibrosis in rats.
Neddylation controls basal MKK7 kinase activity in breast cancer cells.
Sinomenine activation of Nrf2 signaling prevents hyperactive inflammation and kidney injury in a mouse model of obstructive nephropathy.
miR-26a suppresses EMT by disrupting the Lin28B/let-7d axis: potential cross-talks among miRNAs in IPF.
Silence of fibronectin 1 increases cisplatin sensitivity of non-small cell lung cancer cell line.
Glucocorticoid exposure in early placentation induces preeclampsia in rats via interfering trophoblast development.
Sinomenine attenuates renal fibrosis through Nrf2-mediated inhibition of oxidative stress and TGFβ signaling.
The anti-fibrotic effects of microRNA-153 by targeting TGFBR-2 in pulmonary fibrosis.
Pediatric Origins of Nephrolithiasis-Associated Atherosclerosis.
MiR-25 promotes hepatocellular carcinoma cell growth, migration and invasion by inhibiting RhoGDI1.
Protective Effect of the Total Saponins from Rosa laevigata Michx Fruit against Carbon Tetrachloride-Induced Liver Fibrosis in Rats.
IL-33 promotes airway remodeling and is a marker of asthma disease severity.
Benzalkonium chloride induces subconjunctival fibrosis through the COX-2-modulated activation of a TGF-β1/Smad3 signaling pathway.
miR-203 inhibits tumor cell migration and invasion via caveolin-1 in pancreatic cancer cells.
miR-483-5p promotes invasion and metastasis of lung adenocarcinoma by targeting RhoGDI1 and ALCAM.
Reduction of microRNA-206 contributes to the development of bronchopulmonary dysplasia through up-regulation of fibronectin 1.
Brucine, an alkaloid from seeds of Strychnos nux-vomica Linn., represses hepatocellular carcinoma cell migration and metastasis: the role of hypoxia inducible factor 1 pathway.
Global profiling of proteolytically modified proteins in human metastatic hepatocellular carcinoma cell lines reveals CAPN2 centered network.
Liu H, Xia C, Zhang Y, Gan Y, Cheng L, Wang X, Chang A, Zhao W, Li B, Wang Y, Li Y, Rosas I, Yang J, Yu G, Wang L
International journal of biological sciences 2026;22(5):2233-2246
International journal of biological sciences 2026;22(5):2233-2246
TAPI-1 Combined With Silicone Stents Alleviated Severe Traumatic Tracheal Stenosis via the ADAM17/TGF-β1 Pathway.
Yang Z, Pan L, Xie T, Wu H, Liu K, Li Y
Canadian respiratory journal 2026;2026:9485331
Canadian respiratory journal 2026;2026:9485331
Yifei Decoction Regulates the NGF/TRKA/PI3K/AKT Signaling Axis to Inhibit the Epithelial-Mesenchymal Transformation and Proliferation of Pulmonary Epithelial Cells in Bleomycin-Induced Pulmonary Fibrogenesis.
Chen L, Lan C, Deng X, Wu M, Shao M, Yang M, Ma X, Huang F, Wu H
Canadian respiratory journal 2026;2026:6614209
Canadian respiratory journal 2026;2026:6614209
Stem cell therapy targets THBS1 to reverse endometrial fibrosis.
Yu X, Shi L, Qu M, Zhang Y, Zhang Y, Xu X, Liu L, Wang H, Wang H
Frontiers in cell and developmental biology 2026;14:1766915
Frontiers in cell and developmental biology 2026;14:1766915
Propofol Exerted an Anti-Asthmatic Effect by Attenuating Extracellular Matrix Deposition and Viability of Airway Smooth Muscle Cells.
Chen Z, Jiang Y, Zhang H, An X, Zhang Y, Wei L
Immunological investigations 2026 May;55(4):734-749
Immunological investigations 2026 May;55(4):734-749
Astragalus membranaceus Polysaccharides Attenuate Osteoarthritis in Human Primary Chondrocytes and in Animal Model: Mechanism Study Using RNA-Seq and Network Pharmacology.
Xu H, Li Y, Wang J, Xin Y, Xu Q, Qin X, Yang X, Yan Y, Chen Q, Chen Y, Zhang Y, Lu C, Xu K, Wang X
Phytotherapy research : PTR 2026 May;40(5):2249-2269
Phytotherapy research : PTR 2026 May;40(5):2249-2269
Treatment with anti-Hsp90 antibody mitigates fibronectin-related cardiac fibrosis induced by pressure overload in mice.
Marunouchi T, Murakami T, Yamaguchi K, Hiraga K, Ban H, Tanonaka K
Biochemical pharmacology 2026 May;247:117780
Biochemical pharmacology 2026 May;247:117780
Effect of TGFβ-ITGB6 feedback loop on liver metastasis in SMAD4 wild-type pancreatic cancer.
Zhao Y, Qin C, Zhao B, Li Z, Li T, Wang W
Chinese medical journal 2026 May 5;139(9):1388-1401
Chinese medical journal 2026 May 5;139(9):1388-1401
Study on the anti-pulmonary fibrosis mechanism of Renshen Pingfei formula by inhibiting M2 macrophage polarization and regulating TGF - β/SMAD signaling pathway.
Hong L, Sun Y, Hou H, Zhang J, Shi W, Yang Y, Fan X, Zhu J
Journal of ethnopharmacology 2026 May 23;363:121465
Journal of ethnopharmacology 2026 May 23;363:121465
Sodium hyaluronate based multifunctional hydrogels delivering SiRNA for sustained silencing of SMAD3: A novel strategy to treat intrauterine adhesions.
Chen K, Wang J, Liu Q, Wang H, Ning X, Wang J, Hu X, Zong L, Wu L, Luo T, Huang J, Zheng S
Carbohydrate polymers 2026 May 15;380:125123
Carbohydrate polymers 2026 May 15;380:125123
N-acetylglucosamine ameliorates the transition from acute kidney injury to chronic kidney disease by reducing the accumulation of lipid droplets.
Tang Z, Ou Z, Wan H, Tao M, Li X, Huang Y, Tan Q, Peng Q, Dong L, Zhao J
International immunopharmacology 2026 May 15;177:116463
International immunopharmacology 2026 May 15;177:116463
Single-Cell Multimodal Profiling Highlights Persistent Aortic Smooth Muscle Cell Changes in Diabetic Mice Despite Glycemic Control.
Tanwar VS, Malek V, Wang J, Luo Y, Malhi NK, Zhang H, Abdollahi M, Lanting L, Senapati P, Das S, Reddy MA, Zang C, Miller CL, Chen ZB, Natarajan R
Arteriosclerosis, thrombosis, and vascular biology 2026 Mar;46(3):e324012
Arteriosclerosis, thrombosis, and vascular biology 2026 Mar;46(3):e324012
Safeguarding VSMC Contractile Phenotype With In Situ circRNA-mediated Endothelial Olaratumab Engineering to Prevent Vascular Graft Stenosis.
Hu S, Ling S, Liang F, Pan Y, Wang J, Bao W, Zhu J, Wang F, Du Y, Cui W, Yin M
Advanced materials (Deerfield Beach, Fla.) 2026 Mar;38(17):e22615
Advanced materials (Deerfield Beach, Fla.) 2026 Mar;38(17):e22615
Biomimetic epiphysis inspired by natural developmental mechanisms promote the repair of large-scale epiphyseal defects.
Cheng P, Han M, Lu Q, Ning F, Zhao X, Xu C, Wang J, Yang L, Jie Q
Biomaterials 2026 Mar;326:123644
Biomaterials 2026 Mar;326:123644
Dahuang Zhechong pill alleviates pulmonary fibrosis by inhibiting apoptosis and epithelial-mesenchymal transition of type II alveolar epithelial cells in vitro and in vivo.
Sun F, Wu Z, Cai S, Xing X, Wang J, Zhang L
Journal of traditional and complementary medicine 2026 Mar;16(2):210-223
Journal of traditional and complementary medicine 2026 Mar;16(2):210-223
An integrated network pharmacology and proteomics approach reveals the anti-fibrotic effect of Fushen Granule on peritoneal fibrosis.
Yang K, Li J, Wang L, Yu H, Liu X, Gao Z, Wang Z, Zhang L, Yang H
BMC complementary medicine and therapies 2026 Mar 9;26(1)
BMC complementary medicine and therapies 2026 Mar 9;26(1)
Methylated circPTK2 as a driver of fibroblast activation in pulmonary fibrosis.
Zhu Y, Zhao L, Qin J, Guo B, Luo X, Feng Z, Wei J, Huang X, Chen X, Lin Y, Yin F, Huang Y, Zhang Y, Wu J, Fang J, Ding S, Zhang Y, Li Y, Han Q, Shen A, Yu XY
Molecular therapy : the journal of the American Society of Gene Therapy 2026 Mar 4;34(3):1554-1575
Molecular therapy : the journal of the American Society of Gene Therapy 2026 Mar 4;34(3):1554-1575
AG1295 Attenuates High-Glucose-Induced Proliferation, Migration, Phenotype Transition, and Interleukin-6 Expression in Human Corneal Stromal Fibroblasts.
Zheng Y, Jiang H, Wang J, Zhang Q, Wan Q, Wang Y
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2026 Mar 18;:10807683261433333
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2026 Mar 18;:10807683261433333
Renal Tubule-Specific Deletion of Nephrocystin 3 (Nphp3) Causes Infantile Nephronophthisis-like Phenotypes in Mice.
Du X, Wang C, Fang Y, Wang G, Zhai Y, Shen Q, Tang X, Xu H
International journal of molecular sciences 2026 Mar 15;27(6)
International journal of molecular sciences 2026 Mar 15;27(6)
cGAS-STING signaling pathway promotes ischemic kidney injury by regulating HK3-mediated lipid accumulation.
Wang D, Zhou Z, Zhao Z, Liu M, Li Y, Mu L, Zhou H, Li X, Zhang F, Tian S, Zhou X, Shi Y
Free radical biology & medicine 2026 Jun;249:246-259
Free radical biology & medicine 2026 Jun;249:246-259
Exosomal miRNA let-7i-5p alleviates asthma triggered by RSV-induced exosomes by regulating dendritic cell autophagy via the MITF/DAP1/P70S6K pathway.
Liu J, Yao B, Wang S, Deng Y, Xie J, Jiao L, Hu Y, Zhou Z, Ding Y, Luo Y, Wang M
Cellular signalling 2026 Jul;143:112491
Cellular signalling 2026 Jul;143:112491
Comparing Effects of Short- and Long-Term Exposure of Cigarette Smoke Extract on Human Vocal Fold Fibroblasts.
Steffan B, Grossmann T, Grill M, Kirsch A, Groselj-Strele A, Gugatschka M
Journal of voice : official journal of the Voice Foundation 2026 Jan;40(1):149-159
Journal of voice : official journal of the Voice Foundation 2026 Jan;40(1):149-159
CSB6B attenuates renal inflammation and fibrosis by inhibiting the activation of NLRP3 inflammasome through the NLRP3/Caspase-1/GSDMD/IL-1β signaling pathway.
Chen S, Zhu Y, Chen T, Xu Y, Fan Q
Pathology, research and practice 2026 Jan;277:156286
Pathology, research and practice 2026 Jan;277:156286
Unveiling Novel Biomarkers: Ferroptosis and m1A in the Progression of Nanographene-Induced Lung Fibrosis.
Xia J, Wu W, Fan H, Tang X, Li S, Tang K, Hao C, Xu Q, Zhao Y, Yao W
Small (Weinheim an der Bergstrasse, Germany) 2026 Jan;22(5):e08818
Small (Weinheim an der Bergstrasse, Germany) 2026 Jan;22(5):e08818
Yujie recipe attenuates bleomycin-induced pulmonary fibrosis via suppressing NF-κB/NLRP3 signaling in a Nrf2-dependent manner.
Qin L, Zhao B, Xiong Y, Chen L, Qi S, Ma Y, Zeng H, Song Y, Liu W, Tian T, Ge G
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157607
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157607
Design of RGD-functionalized GSH-responsive pegylated polymeric protacs for selective BRD4 degradation and EndMT-driven cardiac fibrosis inhibition.
Bi T, Chen L, Wang T, Miao W, Zhai S, Huang R, Sun Q, Chen Y, Su H, Zhou J, Li R, Huang W, Yao X, Luo P, Liu Z
Journal of nanobiotechnology 2026 Jan 30;24(1)
Journal of nanobiotechnology 2026 Jan 30;24(1)
Bacteriocin-transport-inspired oral peptide-probiotic delivery ameliorates IBD complications via autophagy and gut homeostasis.
Yu Y, Bu Y, Shen C, Lin B, Lu C, Zhu L, Shen Z, Li C, Li X
Science advances 2026 Jan 2;12(1):eadz9069
Science advances 2026 Jan 2;12(1):eadz9069
Neuroprotective Effects of Desert Milk Exosomes in LPS-Induced Cognitive Decline: Role of Microglial M2 Polarization and AMPK Signaling.
Li Y, Lu W, Qian W, Liao X, Wang P, Wang Y, Jiao W, Wang M, Zhao J, Yang J, Gao H, Li H
Nutrients 2026 Jan 19;18(2)
Nutrients 2026 Jan 19;18(2)
Discovery of XRF-1021, a 2,4-disubstituted-5-fluoropyrimidine derivative as a homeodomain-interacting protein kinase 2 inhibitor for the treatment of chronic kidney disease.
Hu X, Wang S, Fu S, Zeng J, Wu Y, Gong L, Cao Y, Zhang Y, Han Y, Ouyang H, Xiong Y, He X, Cheng J, Zou S, Chen Z, Tao L, Meng J, Huang L, Yuan Q, Peng Z, Li Q
European journal of medicinal chemistry 2026 Jan 15;302(Pt 2):118353
European journal of medicinal chemistry 2026 Jan 15;302(Pt 2):118353
A fibroblast-like endothelial cell state promotes atherosclerosis via C/EBPβ-activated TGF-β signaling.
Fan L, Zhu Y, Li Y, Ji Z, Ma K, Zhang Y, Wei L, Chen J, Jiang Y, Lai D, Qin L, Fu G, Simons M, Xu L, Yu L, Qiu C
The EMBO journal 2026 Feb;45(4):1077-1108
The EMBO journal 2026 Feb;45(4):1077-1108
Intestinal metabolite TMAO promotes CKD progression by stimulating macrophage M2 polarization through histone H4 lysine 12 lactylation.
Tang Y, Li Y, Yang X, Lu T, Wang X, Li Z, Liu J, Wang J
Cell death and differentiation 2026 Feb;33(2):314-326
Cell death and differentiation 2026 Feb;33(2):314-326
TREM2 Facilitates Myelin Debris Clearance but Exacerbates Chronic Inflammation and Fibrosis After Spinal Cord Injury.
Wu Z, Yu S, Hu Y, Hu X, Yang L, Jiang Y, Zhang M, Mu Y, Li Z, Yao F, Tian D, Jing J, Cheng L
CNS neuroscience & therapeutics 2026 Feb;32(2):e70777
CNS neuroscience & therapeutics 2026 Feb;32(2):e70777
Silencing the fibronectin gene (FN1) improves NaCl-induced cardiac fibrosis via ferritinophagy-mediated ferroptosis in a nuclear receptor coactivator 4 (NCOA4)-dependent manner.
Dai Y, Li Y, Yang X, Zhou Y, Mao Y, Chuanxi Y, Li P, Zhao K
British journal of pharmacology 2026 Feb;183(3):581-597
British journal of pharmacology 2026 Feb;183(3):581-597
Mettl3-Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS.
Zhu F, Li H, Li X, Du C, Wang T, Zhou X, Xie X, Shao Y, Huang Y, Hu Y, Guo X, Zhu B, Yu S, Zhang X, Zhao B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(10):e01242
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(10):e01242
Ubiquitination degradation of GATA4 by CUL4B promotes ovarian cancer metastasis by inducing lysosomal acidification.
Yin X, Gao R, Geng Y, Mu X, Zhang Y, Ma Y, Chen X, Han F, Chen Z, Li F, He J
Genome biology 2026 Feb 9;27(1)
Genome biology 2026 Feb 9;27(1)
aFGF rescues high glucose-induced senescent fibroblasts and improves diabetic wound healing by regulating SIRT1/STAT3 pathway.
Wang X, Lu M, Jia S, Zhang J, Wang X, Qi Y, Shi N, Jiao Y, Zhao J, Wang X, Zhang J, Jiang D
Scientific reports 2026 Feb 9;16(1)
Scientific reports 2026 Feb 9;16(1)
Uncovering a Glaucoma-Linked Lysophosphatidic Acid-MAPK/AP-1 Fibrosis Axis in Human Trabecular Meshwork Cells and Its Modulation by Diospyros kaki Leaf Extract.
Jeon Y, Kwon H, Ahn HR, Huh G, Kim T, Park YT, Park HB, Jeong JH, Jo JH, Kim YJ, Jung SH
International journal of molecular sciences 2026 Feb 4;27(3)
International journal of molecular sciences 2026 Feb 4;27(3)
Exosomal microRNAs of tuberculous pleural effusion orchestrating TGF-β signaling mediate pleural fibrosis.
Jiang LJ, Zheng YY, Liang LM, Jia ZH, Du RH, Huang H, Dai X, Cheng PP, Zhao LQ, Li Q, Jiang YH, Cui XL, Ye SY, Hu SH, Zhang HD, Lian CY, Feng X, Song LJ, Yu F, He XL, Xiong L, Xiang F, Wang X, Liu AD, Wang M, Ye H, Ma WL
Respiratory research 2026 Feb 3;27(1)
Respiratory research 2026 Feb 3;27(1)
Targeted inhibition of RGS19 alleviates renal fibrosis by restoring autophagy and modulating immune cell infiltration.
Niu X, Zhao Y, Li L, Xu X, Xu C, Wu J, Yu X, Chen Y, Rong R, Xu B
Journal of nanobiotechnology 2026 Feb 28;24(1)
Journal of nanobiotechnology 2026 Feb 28;24(1)
IGFBP-5/TGF-β1 mediated crosstalk between endothelial and tubular epithelial cells promotes interstitial fibrosis.
Wang S, Song C, Chi K, Fu Z, Zhang X, Geng X, Liu C, Cai G, Chen X, He JC, Hong Q, Wu D
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2026 Feb 27;41(3):531-544
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2026 Feb 27;41(3):531-544
Integrative analysis of single-cell RNA sequencing, bulk RNA sequencing, and proteomic data identified NOTCH3 as a hub gene contributing to human intervertebral disc fibrosis.
Ding Q, Chen X, Zheng Q, Dou Q, Zuo C, Wang Q, Shen C
Scientific reports 2026 Feb 26;16(1)
Scientific reports 2026 Feb 26;16(1)
Ultraviolet-induced Glycyrrhiza polysaccharide hydrogels with different mechanical strength for wound management.
Wang Z, Luo M, Ni L, Li Y, Liu D, Zhu H, Xia B, Liu Y, Liu Q, Yang B
Carbohydrate polymers 2026 Feb 15;374:124712
Carbohydrate polymers 2026 Feb 15;374:124712
Cadmium exposure induces renal fibrosis by inhibiting hsa_circ_0075684/miR-363-3p/KLF4 signaling pathway.
Zhou J, Huang Y, Li G, Zhao Z, Deng Y, Xian S, Hu Y, Yi M, Liu L
Scientific reports 2026 Feb 13;16(1)
Scientific reports 2026 Feb 13;16(1)
Integrated network pharmacology and bioinformatics analysis reveals MME as key target of Notoginsenoside R1 in diabetic nephropathy.
Gan X, Liang M, Shadekejiang H, Hong H, Lu J, Li X, Zhang X, Lu C
BMC complementary medicine and therapies 2026 Feb 1;26(1)
BMC complementary medicine and therapies 2026 Feb 1;26(1)
Fibrotic scar formation after cerebral ischemic stroke: Targeting the Sonic hedgehog signaling pathway for scar reduction.
Wen J, Tang H, Tian M, Wang L, Yang Q, Zhao Y, Li X, Ren Y, Wang J, Zhou L, Tan Y, Wu H, Cai X, Wang Y, Cao H, Xu J, Yang Q
Neural regeneration research 2026 Feb 1;21(2):756-768
Neural regeneration research 2026 Feb 1;21(2):756-768
A translational systems medicine approach to devising nanotherapeutics for targeted intervention of MASLD.
Luo Z, Wu J, Xu B, Wu D, Zhong Y, Hao M, Xu Y, Yang J, Wang Y, Lauschke VM, Ying S, Cheng N
Biomaterials 2026 Aug;331:124089
Biomaterials 2026 Aug;331:124089
Three-dimensional cell culture in vitro could better recapitulate the biological behavior of cells in vivo.
Qi Z, Yang S, Fu C, Xu J, Li Q, Yan J, Shen A, Hu B
Tissue & cell 2026 Apr;99:103246
Tissue & cell 2026 Apr;99:103246
Flexible Bioactive Glass-Fiber-Reinforced Recombinant Collagen Sponge for Versatile Hemostasis, Antibacterial Protection, and Functional Skin Regeneration.
Fan Z, Li M, Cai K, Xie Z, Lu B, Zhang M, Zhang Y, Wang J, Gu C, Zheng K, Chen T
Advanced healthcare materials 2026 Apr;15(16):e04908
Advanced healthcare materials 2026 Apr;15(16):e04908
Extracellular vesicles derived from senescent hepatocytes drive pan-cancer metastasis in aging.
Li H, Zhao R, Wan L, Yuan Y, Ma E, Li Y, Chen Z, Liu B, Song Y, Cao Z, Jiao X, Wang Y, Wu P, Jin H, Li J, Yang X, Huang L, Zhang Y, Yang K, Huo J, Jin H, Zhong H, Min M, Zhang S, Cao Y, Li W, Zhang R, Wei C
Nature aging 2026 Apr 6;
Nature aging 2026 Apr 6;
Targeting SAT1 alleviates high glucose-induced tubular ferroptosis and fibrosis: implications for diabetic kidney disease.
Tang Y, Wang S, Wang Y, Zhang T, Liu Y, Di Y
Histochemistry and cell biology 2026 Apr 5;164(1)
Histochemistry and cell biology 2026 Apr 5;164(1)
DOT1L Drives Endothelial-to-Mesenchymal Transition and Fibrotic Vascular Remodeling via H3K79 Methylation.
Wang Y, Peng X, Chen J, Zhang Y, Zhang T, Zhang J, Fan J, Zheng H, Liu Q, Song Z, Huang ZP, Meng S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr 3;:e15581
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr 3;:e15581
Knockdown of METTL3 ameliorated myofibroblast activities in oral submucous fibrosis through upregulating DKK3.
Peng J, Guo S, Zhang P
Tissue & cell 2026 Apr 20;102:103544
Tissue & cell 2026 Apr 20;102:103544
The mechanism of fibronectin 1 promoting papillary thyroid cancer progression by regulating anoikis resistance.
Zhang S, Gu X, Zhai X, Huang H, Zhang R, Ye H
Scientific reports 2026 Apr 19;
Scientific reports 2026 Apr 19;
Non-steroidal mineralocorticoid receptor antagonist finerenone ameliorates diabetic nephropathy via suppressing SLC7A11-mediated ferroptosis.
Yu L, Zhai Z, Wang Y, Wang L, Li Q, Guo Y, Liang Y, Tang L
International immunopharmacology 2026 Apr 15;175:116448
International immunopharmacology 2026 Apr 15;175:116448
BRD2 is a transcriptional coactivator of Smad3 in mediating TGF-β tumor suppressive responses.
Tian S, Gu S, Sun S, Wang Z, Zhao Y, Yuan B, Liu X, Zhao B, Xu P, Cao J, Xiao M, Yu Y, Feng XH
Oncogene 2026 Apr 15;
Oncogene 2026 Apr 15;
A novel gene edited rat model of cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL).
Monte B, Davis J, Zhu X, Xu F, Majchrzak M, Cabral MJ, Van Nostrand WM, Healey B, Koundal S, Lee H, Robinson JK, Benveniste H, Van Nostrand WE
Cerebral circulation - cognition and behavior 2025;9:100401
Cerebral circulation - cognition and behavior 2025;9:100401
SESN2 inhibits tubular exosome secretion and diabetic kidney disease progression by restoring the autophagy‒lysosome pathway.
Zheng Z, Chen J, Xue X, Ma X, Zhang S, Wang M, Xue Y, Jia Y
International journal of biological sciences 2025;21(9):4215-4230
International journal of biological sciences 2025;21(9):4215-4230
Cancer-associated Fibroblast-like Cells Promote Osteosarcoma Metastasis by Upregulation of Phosphoserine Aminotransferase 1 and Activation of the mTOR/S6K Pathway.
Feng L, Xiao G, Chen Y, Ye T, Fan L, Xie Y, Mei T, Wang L, Ge J, Ye C, Chen J
International journal of biological sciences 2025;21(9):4153-4171
International journal of biological sciences 2025;21(9):4153-4171
Inhibition of Mettl3 alleviates low-dose cisplatin-induced renal fibrosis and enhances the chemotherapeutic efficacy in mouse models of cancer.
Xie Y, Li H, Pan J, Li Y, Zhang D
International journal of biological sciences 2025;21(10):4293-4311
International journal of biological sciences 2025;21(10):4293-4311
Umbilical Cord Mesenchymal Stem Cells Attenuate Podocyte Injury in Diabetic Nephropathy Rats by Inhibiting Angpltl4/Integrin β3 in the Glomerulus.
Liu S, Meng M, Huang C, He L, Wang P, Tang Z, Ran X, Gao H, Guo Y, He Y, Chen J, Hu H, He S, Zhao Y, Hou Z, Li L, Li W, Wang W, Wang X
Journal of diabetes research 2025;2025:6683126
Journal of diabetes research 2025;2025:6683126
Targeting interferon-stimulated gene of 20 kDa protein (Isg20) inhibits ribosome biogenesis to ameliorate the progression of renal fibrosis.
Liu X, Wang H, Wang K, Liu Y
PloS one 2025;20(7):e0322639
PloS one 2025;20(7):e0322639
FAK-Induced Time Dependent Cell Response Profiling: Prediction, Identification, and Analysis of Anti-Tumor Immune Natural Products.
Jin L, Chen M, Lou J, Fu J, Bai N, Liu X, Mao W, Li Z, Shou Q, Fu H
Drug design, development and therapy 2025;19:9079-9097
Drug design, development and therapy 2025;19:9079-9097
Cordycepin Ameliorates Renal Interstitial Fibrosis by Inhibiting Drp1-Mediated Mitochondrial Fission.
Sun Y, Jin S, Chen J, Zhang J, Lu Y, Gu Q, Yan Z, Chen W, Chen A, Fang Y, Geng W, Xu X, Song N
Drug design, development and therapy 2025;19:1271-1287
Drug design, development and therapy 2025;19:1271-1287
Single-Cell RNA-Seq Uncovers Cellular Heterogeneity from Deep Fascia in Necrotizing Fasciitis Patients.
Wang T, Zhang L, Chen W, Long Y, Zhang Y, Wang L, Hou Z
Journal of inflammation research 2025;18:995-1012
Journal of inflammation research 2025;18:995-1012
SIRT1 Enhancement is Required for the Induction of Anti-Inflammatory Effect of Micheliolide in Carbon Tetrachloride Induced Liver Fibrosis in Mice.
Jin C, Jiang A, Chang J, Hu Y, Wang Y, Zhao R, Shi J, Wu H, Han Z, Liu Z
Journal of inflammation research 2025;18:16231-16245
Journal of inflammation research 2025;18:16231-16245
Identification of Novel Gene Signature Predicting Lymph Node Metastasis in Papillary Thyroid Cancer via Bioinformatics Analysis and in vitro Validation.
Li H, Sun D, Jin K, Wang X
International journal of general medicine 2025;18:1463-1479
International journal of general medicine 2025;18:1463-1479
NETs drive myocardial fibrosis in hypertension via an NF-κB/ferroptosis axis.
Tu Q, Gong X, Yuan X, Tang Y, Huang R, Jiang Q, Li W
Frontiers in immunology 2025;16:1712786
Frontiers in immunology 2025;16:1712786
Isorhamnetin attenuates renal interstitial fibrosis by targeting TWEAK/Fn14-mediated epithelial-mesenchymal transition.
Chen Y, Luo W, Guan H, Chen Z, Chen Z, Xiao L, Xu W, Huang M, Lin Y, Zhang Y, Peng W, Nan L
Frontiers in immunology 2025;16:1649327
Frontiers in immunology 2025;16:1649327
Identification of regulatory cell death-related genes during MASH progression using bioinformatics analysis and machine learning strategies.
Lin Z, Li W, Xu Y, Liu H, Zhang Y, Li R, Zhao W, Guan Y, Zhang X
Frontiers in immunology 2025;16:1542524
Frontiers in immunology 2025;16:1542524
Yiqi Qingre Gao alleviates renal fibrosis in UUO mice via PI3K/AKT pathway.
Jin Q, Li Q, Yang L, Ma F, Mao H, Wang Y, Liu T, Peng L, Li P, Zhan Y
Frontiers in pharmacology 2025;16:1538061
Frontiers in pharmacology 2025;16:1538061
Xanthohumol ameliorates diabetic kidney disease through suppression of renal fibrosis by regulating SNHG10/miR-378b.
Hao J, Li H, Yu W
Frontiers in pharmacology 2025;16:1532517
Frontiers in pharmacology 2025;16:1532517
Dimethyl malonate alleviates obstructive nephropathy by enhancing renal metabolism and inhibiting kidney oxidative stress and inflammation.
Zhang W, Fu C, Lai J, Xin J, Zhang W
Frontiers in pharmacology 2025;16:1530635
Frontiers in pharmacology 2025;16:1530635
CAV1 promotes epithelial-to-mesenchymal transition (EMT) and chronic renal allograft interstitial fibrosis by activating the ferroptosis pathway.
Han Q, Ni B, Bao W, Zhang J, Zheng M, Miu J, Wang Z, Yuan J, Tao J, Han Z, Gu M, Ju X, Tan R
Frontiers in immunology 2025;16:1523855
Frontiers in immunology 2025;16:1523855
Genome-wide CRISPR/Cas9 screening identifies key profibrotic regulators of TGF-β1-induced epithelial-mesenchymal transformation and pulmonary fibrosis.
Tan C, Wang J, Ye X, Kasimu K, Li Y, Luo F, Yi H, Luo Y
Frontiers in molecular biosciences 2025;12:1507163
Frontiers in molecular biosciences 2025;12:1507163
The Paeonol of Total Glucosides of White Peony Regulates the Differentiation of CD4+Treg Cells through the EP300/Foxp3 Axis to Relieve Pulmonary Fibrosis in Mice.
Yan M, Wang Q, Yang H, Liu D, Liang W, Chen H
Cell biochemistry and biophysics 2025 Sep;83(3):3959-3970
Cell biochemistry and biophysics 2025 Sep;83(3):3959-3970
Prolyl hydroxylase-2 (EGLN1) mediates TGF-β1 pathway regulated epithelial-mesenchymal transition in yak kidneys.
Bai X, Lu H, Lu Z, Yu S, Ma R, He J, Cui Y
International journal of biological macromolecules 2025 Sep;321(Pt 3):146522
International journal of biological macromolecules 2025 Sep;321(Pt 3):146522
Integrin αvβ6 mediates the effects of age-related decreases in matrix stiffness on Tenon's fibroblast activation and bleb scarring in glaucoma.
Feng L, Xiong W, Yin J, Guan D, Li H, Cao J, Zhu Z, Zhang W, Zhang F
Experimental eye research 2025 Sep;258:110459
Experimental eye research 2025 Sep;258:110459
Multi-omics analysis of the active components and mechanisms of Baojin Chenfei formula in silica-induced murine silicosis.
Wr H, Yq L, Xg L, Yf Z, Y W, P Z, Js L, Q Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:156986
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:156986
PINK1 deficiency alleviates bleomycin-induced pulmonary fibrosis in mice.
Gu YQ, Wu J, Wang T, Yu YF, Han J, Chen YL, Hu XL, Wu M, Hu H, Zhang WP, Lu YB, Jiang B
Cellular signalling 2025 Sep;133:111868
Cellular signalling 2025 Sep;133:111868
Exploring the mechanism of action of trastuzumab-induced cardiomyocyte atrophy based on the FN1/PI3K/AKT-mediated mTOR-independent signaling pathway.
Zhu M, Yang Y, Fang H, Chen R
Genomics 2025 Sep;117(5):111087
Genomics 2025 Sep;117(5):111087
Yishen Qufeng formula mediates ferroptosis to improve renal fibrosis in unilateral ureteral obstruction rats.
Gao J, Wei Y, Zhang W, Yu Y, Ge H, Tian F, Zhou E
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120376
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120376
4EBP1 phosphorylation mediates TGF-β1-induced hepatic fibrosis and upregulates HIF-1α expression.
Shi Y, Lin Z, Zhang C, Cui J, Mao Y, Sun M, Zhao D, Nan Y, Sun D
iScience 2025 Sep 19;28(9):113412
iScience 2025 Sep 19;28(9):113412
Targeting USP21 to inhibit abdominal aortic aneurysm progression by suppressing the phenotypic transition of vascular smooth muscle cells.
Zhang H, Yue H, Sun Y, Sun G, Yang K, Jiang T, Cui S, Liu Y, Guo Y, Zhang W, Zhang C, Chen Y, Xu F
Cell reports. Medicine 2025 Sep 16;6(9):102328
Cell reports. Medicine 2025 Sep 16;6(9):102328
Decabromodiphenyl ethane induces intrauterine growth restriction by suppressing placental angiogenesis via TWIST2/NAT10-mediated ac4C-dependent TGF-β1 mRNA stabilization.
Ling R, Yin X, Ma L, Zhang Y, Ma Y, Gao R, Geng Y, Mu X, Chen X, Li F, He J
Journal of hazardous materials 2025 Sep 15;496:139377
Journal of hazardous materials 2025 Sep 15;496:139377
Podoplanin-TGF-β1 Autocrine Loop: Pivotal Regulator of Islet Stellate Cell Activation via Cell Deformation, Orchestrating Islet Fibrosis in Diabetes.
Wang X, Wang Q, Yuan Y, Ni C, Cai Z, Qiu S, Li T, Chen Y, Wang J, Wang H, Carvalho V, Sun Z, Liu L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Sep 15;39(17):e70970
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Sep 15;39(17):e70970
Lithospermic acid improves diabetic kidney fibrosis by regulating Piezo1/TGF-β1/Smad signaling pathway.
Yan Y, Wang C, Luo S, Hong T, Niu W, Sun X, Zhang E, Yang M, Li Z, Liu J, Zheng Z, Li J
European journal of pharmacology 2025 Sep 15;1003:177896
European journal of pharmacology 2025 Sep 15;1003:177896
Magnesium ions attenuate tendon graft fibrosis during its ligamentization after ACL reconstruction through modulation of fibroblast to myofibroblast trans-differentiation by promoting PGE2 secretion.
Xu C, Luo Y, Cai Z, Ji J, Guo Z, Cai Z, You C, Zhou Y, Chen Z, Zhang W, Gong N, Wang J
Bioactive materials 2025 Oct;52:474-491
Bioactive materials 2025 Oct;52:474-491
Bioengineered platelet nanoplatform enables renal-targeted dexamethasone delivery for chronic nephritis therapy with dual anti-inflammatory/anti-fibrotic effects and minimized systemic toxicity.
Zhang L, Gong H, Gong X, Zhou B, Wang X, Fei S, Xia D, Xu C, Huang X
Bioactive materials 2025 Oct;52:213-227
Bioactive materials 2025 Oct;52:213-227
CCP1 Inhibits Pulmonary Fibrosis by Suppressing Fibrotic Progression Through the EIF4B/PI3K/AKT Pathways.
Ren Q, Pan Y, Tian Z, Jiao G, Liu X
Cell biology international 2025 Oct;49(10):1245-1261
Cell biology international 2025 Oct;49(10):1245-1261
Isoimperatorin Reduces Synovial Inflammation and Fibrosis in Knee Osteoarthritis via the cAMP Signalling Pathway.
Jie L, Liu J, Zhu Z, Huang Z, Liu Y, Liu G, Shen X, Li Y, Shi X
Journal of cellular and molecular medicine 2025 Oct;29(19):e70880
Journal of cellular and molecular medicine 2025 Oct;29(19):e70880
Triamcinolone Acetonide (TCA)-Loaded Biodegradable Microspheres Improve Therapeutic Outcomes in Thyroid-Associated Ophthalmopathy (TAO) by Reducing Fibrosis and Adipogenesis.
Xie B, Xiong W, Zhang F, Cao J, Chenzhao C, Chen X
Journal of biomedical materials research. Part A 2025 Oct;113(10):e38000
Journal of biomedical materials research. Part A 2025 Oct;113(10):e38000
CAMKK2 restored mitochondrial dynamics homeostasis to alleviate pulmonary fibrosis via AMPK/PGC-1α signaling pathway in lung fibroblasts.
Zhou Y, Wang Y, Wang M, Li B, Xu K, Pan X, Li Z, Wang Q, He W, Pang J, Guo Y, Zhang Y, Sakamoto K, Yang J, Wang L, Yu G
Molecular medicine (Cambridge, Mass.) 2025 Oct 6;31(1):308
Molecular medicine (Cambridge, Mass.) 2025 Oct 6;31(1):308
Functional metabolomics revealed pyroglutamic acid may play a key role in idiopathic pulmonary fibrosis.
Wen Y, Nie JH, Qin XM, Li ZY
Journal of pharmaceutical and biomedical analysis 2025 Oct 15;264:116967
Journal of pharmaceutical and biomedical analysis 2025 Oct 15;264:116967
Interplay of axon regeneration genes and immune infiltration in spinal cord injury.
Xiang Z, Fang D, Gao D, Zhang Q, Zhang Y, Sun Y, Li L, Zhang X, Li J, Ding L
Journal of translational medicine 2025 Oct 1;23(1):1034
Journal of translational medicine 2025 Oct 1;23(1):1034
Faecalibacterium prausnitzii alleviates Graves' orbitopathy by modulating short-chain fatty acid (SCFA) metabolism and inhibiting orbital fibrosis and adipogenesis.
Qi X, Zhang J, Li Y, Shi Y, Yao J, Tong B
Archives of biochemistry and biophysics 2025 Nov;773:110588
Archives of biochemistry and biophysics 2025 Nov;773:110588
Lysyl oxidase-like 2 inhibition alleviates subretinal fibrosis in neovascular age-related macular degeneration model.
Yang X, Ma A, Liu Y, He Z, Yu J, Su S, Chen J, Sang A
Experimental eye research 2025 Nov;260:110588
Experimental eye research 2025 Nov;260:110588
Aristolochic acid I promotes renal tubulointerstitial fibrosis by activating the mannan-binding lectin serine protease 1-complement system.
Wang C, Zhang H, Wang J, Wu H, Ye J, Zhang Q, Jiang B, Chen L, Wang Y, Cheng S, Ying J, Xiang Y, Cheng Y, Zhang L
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Nov;205:115708
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Nov;205:115708
GATA1 promotes TGF-β1-induced epithelial-mesenchymal transition by regulating GSDMB in human bronchial epithelial cells.
Li JJ, Chen JH, Yuan Y, Li L, Zhou C, Chen H, Geng J, Cao Q, Jin R
Molecular immunology 2025 Nov;187:229-239
Molecular immunology 2025 Nov;187:229-239
A novel off-liver sinusoidal progenitor cells in supporting transplantable bioliver engineering.
Lai J, Hu D, Yan M, Chen Q, Shi H, Yang Q, Ding M, Li L, Zhang H, Bai L
Biomaterials advances 2025 Nov;176:214358
Biomaterials advances 2025 Nov;176:214358
Quercetin ameliorates renal injury by promoting UCP1-mediated alleviation of lipid accumulation in diabetic kidney disease.
Yong W, Li Z, Xu W, Gao D, Sha B, Jin Y, Shen Y, Zhang Y, Pan Y, Liu J, Zhang F, Yu J, Jin L, Yang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov;147:157213
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov;147:157213
MicroRNA-93-5p alleviates uric acid-induced fibrosis in renal tubular epithelial cells by regulating the SMAD5/Id2 signaling pathway.
Lu X, Ma C, Li D, Yang J, Sun Y, Liu B, Zhao B, Li H
Cellular signalling 2025 Nov;135:112081
Cellular signalling 2025 Nov;135:112081
Integrated analysis of single-cell RNA-seq and ATAC-seq in lens epithelial cells: Unveiling the role of ATF6 as a key transcription factor.
Lu H, Liu X, Zhou Q, Li R, Zuo H, Hu K, Tian M, Wang H, Li J, Li N, Hou S
Genes & diseases 2025 Nov;12(6):101610
Genes & diseases 2025 Nov;12(6):101610
Role of TRPV6-Mediated Calcium Signaling in High-Glucose-Inhibited Keratinocyte Migration.
Zhang X, Wang Y, Kang Q, Chen Y, Chang H, Ai L, Shen B, Xie M, Jiang W, Zhang Q
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Nov 30;39(22):e71270
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Nov 30;39(22):e71270
Artificial Intelligence-Driven Discovery of Pyrazolo[1,5-a]pyrimidine Derivatives as Novel Phosphodiesterase 4 Inhibitors for Treating Idiopathic Pulmonary Fibrosis.
Li Z, Huan W, Liu X, Zhang K, Wang X, Huang Y, Zhou Q, Huang S, Sang Z, Luo HB
Journal of medicinal chemistry 2025 Nov 27;68(22):24436-24455
Journal of medicinal chemistry 2025 Nov 27;68(22):24436-24455
TRIM36 inhibits lung fibroblast activation and pulmonary fibrosis through the degradation of phospho-AKT1.
Li Y, Yang Y, Wang Y, Shi F, Zhang Y, Wen H, Pan X, Xia C, Li Z, Cui K, Zhao G, Liu H, Wang Q, Wang L, Yu G
iScience 2025 Nov 21;28(11):113775
iScience 2025 Nov 21;28(11):113775
HMGA1 drives EMT in obliterative bronchiolitis through epigenetic regulation of chromatin accessibility in pulmonary epithelial cells.
Xia T, Hou Z, Wang S, Sun J, Yang H, Miao P, Liu C, Zheng W, Wei L
Clinical epigenetics 2025 Nov 18;17(1):192
Clinical epigenetics 2025 Nov 18;17(1):192
Engineering Three-Dimensional Cellular Organization by Regulating Bound Water-Mediated Cell-Substrate Interactions for Disease Modeling.
Kawahara M, Miyazaki K, Anada T, Kobayashi S, Tanaka M
ACS omega 2025 Nov 18;10(45):54951-54966
ACS omega 2025 Nov 18;10(45):54951-54966
TGF-β2 increases eHSP90α secretion via upregulating secretory autophagy pathway.
Li J, Li J, Xie T, Huang S, Tian H, Liu M, Kong X, Zhang D, Nawaz KI, Wang M, Li H, Zhang J, Yuan F, Guo W, Cui X, Mu H, Hu Y
Cell communication and signaling : CCS 2025 Nov 12;23(1):492
Cell communication and signaling : CCS 2025 Nov 12;23(1):492
Poricoic Acid A attenuated TGF-β1-induced epithelial-mesenchymal transition in renal tubular epithelial cells through SPRY2/ERK signaling pathway.
Xiang M, Chen H, Lin X
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2025 Nov 1;29(6):727-739
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2025 Nov 1;29(6):727-739
Radiation Induces Pericyte-Myofibroblast Transition.
Yamazaki T, Jordan KR, Fox N, Young KH
International journal of radiation oncology, biology, physics 2025 Nov 1;123(3):860-875
International journal of radiation oncology, biology, physics 2025 Nov 1;123(3):860-875
Chaihu Guizhi Ganjiang Decoction ameliorates chronic pancreatitis by modulating the SK1/S1P signaling pathway.
Yao GW, Li CX, Fan YX, Zhuo YZ, Zhang SK, Cui LH
Journal of natural medicines 2025 May;79(3):706-720
Journal of natural medicines 2025 May;79(3):706-720
Unveiling 8,12-Dimethoxysanguinarine: A Potent Inhibitor of Breast Cancer Metastasis via Fibronectin 1 Downregulation.
Xi X, Qi Y, Zhang M, Yang P, Huang X
Chemistry & biodiversity 2025 May;22(5):e202402489
Chemistry & biodiversity 2025 May;22(5):e202402489
13-Methylpalmatine alleviates bleomycin-induced pulmonary fibrosis by suppressing the ITGA5/TGF-β/Smad signaling pathway.
Mao Q, Liu J, Yan Y, Wang G, Zhang M, Wang Z, Wen X, Jiang Z, Li H, Li J, Xu M, Zhang R, Yang B
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156545
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156545
Inhibition of sphingosine 1-phosphate receptor 3 ameliorates bleomycin-induced pulmonary fibrosis by suppressing macrophage M2 polarization.
Qiu H, Liu J, You J, Zhou O, Hao C, Shu Y, Ma D, Zou W, Zhang L, Liu E, Luo Z, Ren L, Geng G, Zou L, Peng D, Fu Z
Genes & diseases 2025 May;12(3):101244
Genes & diseases 2025 May;12(3):101244
Semaphorin 3E-Plexin D1 Axis Drives Lung Fibrosis through ErbB2-Mediated Fibroblast Activation.
Deng Z, Chen J, Yang R, Zhan Y, Chen S, Zhang J, Fu H, Gu Y, Huang Q, Wu J, Shan L, Gounni AS, Xie J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(18):e2415007
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(18):e2415007
LncRNA SYISL promotes fibroblast myofibroblast transition via miR-23a-mediated TRIOBP regulation.
Xia C, Cheng L, Zhao W, Chang A, Wang Z, Liu H, Pan X, Li W, Koji S, Li Z, Li B, Wang L, Yu G
Cellular and molecular life sciences : CMLS 2025 May 27;82(1):214
Cellular and molecular life sciences : CMLS 2025 May 27;82(1):214
Mesenchymal stem cell exosomes regulate TGFβ/Smad3 by decreasing the METTL3-NEAT1 axis to inhibit scar progression after breast surgery.
Du J, Wu J, Song Q, Li S, Hong Y, Anwar A, Fu Q, Liu J
Journal of molecular histology 2025 May 20;56(3):161
Journal of molecular histology 2025 May 20;56(3):161
SMARCA4 Inhibits Breast Cancer Progression and Metastasis through RHOA Suppression.
Sun Z, Li Z, Wei Y, Xu L, Hang X, Kang Y
Cancer research 2025 May 15;85(10):1803-1818
Cancer research 2025 May 15;85(10):1803-1818
Basal and AT2 cells promote IPF-lung cancer co-occurrence via EMT: Single-cell analysis.
Ren C, Zi Y, Zhang X, Liao X, Chen H
Experimental cell research 2025 May 15;448(2):114578
Experimental cell research 2025 May 15;448(2):114578
Vascular grafts with a mimetic microenvironment extracted from extracellular matrix of adipocytes can promote endothelialization in vivo.
Wang J, Xu M, Liu H, Wang D, Zhang H, Xu Z, Shi X, Liu X, Tan Z
Acta biomaterialia 2025 May 15;198:49-62
Acta biomaterialia 2025 May 15;198:49-62
Digoxin promotes anoikis of circulating cancer cells by targeting Na(+)/K(+)-ATPase α3-isoform.
Numata Y, Fujii T, Toda C, Okumura T, Manabe T, Takeda N, Shimizu T, Tabuchi Y, Fujii T, Sakai H
Cell death & disease 2025 May 11;16(1):373
Cell death & disease 2025 May 11;16(1):373
A novel lncRNA ABCE1-5 regulates pulmonary fibrosis by targeting KRT14.
Gao S, Wei Y, Li C, Xie B, Zhang X, Cui Y, Dai H
American journal of physiology. Cell physiology 2025 May 1;328(5):C1487-C1500
American journal of physiology. Cell physiology 2025 May 1;328(5):C1487-C1500
Preclinical studies on the antitumor and non-toxic effect of combining pirfenidone with vinorelbine and carboplatin in non-small cell lung cancer.
Branco H, Rodrigues CA, Oliveira J, Mendes N, Antunes C, Amorim I, Santos LL, Vasconcelos MH, Xavier CPR
International journal of cancer 2025 May 1;156(9):1756-1769
International journal of cancer 2025 May 1;156(9):1756-1769
Lnc PVT1 facilitates TGF-β1-induced human cardiac fibroblast activation in vitro and ISO-induced myocardial fibrosis in vivo through regulating MYC.
Wang J, Lv ZY, Li P, Zhang Y, Li X, Shen DF
Molecular and cellular biochemistry 2025 Mar;480(3):1611-1625
Molecular and cellular biochemistry 2025 Mar;480(3):1611-1625
Engineering a halloysite nanotube-enhanced hydrogel 3D skin model for modulated inflammation and accelerated wound healing.
Xu R, Fu X, Lun L, Jiang W, Situ X, Huang X, Xiong Y, Liu C, Wang F
Bioactive materials 2025 Mar;45:148-161
Bioactive materials 2025 Mar;45:148-161
The novel lysophosphatidic acid receptor 1-selective antagonist, ACT-1016-0707, has unique binding properties that translate into effective antifibrotic and anti-inflammatory activity in different models of pulmonary fibrosis.
Birker-Robaczewska M, Boucher M, Ranieri G, Poirey S, Studer R, Freti D, Schnoebelen M, Froidevaux S, Morrison K, Wyss C, Scherer J, Lescop C, Brotschi C, Bolli MH, Kramberg M, Di Stefano S, Rey M, Iglarz M, Delahaye S, Vezzali E, Sieber P, Schäfer A, Caimi SL, Hesse C, Nayler O
The Journal of pharmacology and experimental therapeutics 2025 Mar;392(3):103396
The Journal of pharmacology and experimental therapeutics 2025 Mar;392(3):103396
Bergapten Ameliorates Renal Fibrosis by Inhibiting Ferroptosis.
Li L, Cai W, Zhang H, Tang J, Yang Y, Huang Y, Xi Q, Zhang R
Phytotherapy research : PTR 2025 Mar;39(3):1355-1371
Phytotherapy research : PTR 2025 Mar;39(3):1355-1371
Protective Effects of Lactoferrin Treatment Against Sodium Arsenite Exposure-Induced Nephrotoxicity.
Li S, Yin Y, Dong X, Xu L, Yang Z, Li H, Zou Y, Wu Z
Biological trace element research 2025 Mar;203(3):1539-1554
Biological trace element research 2025 Mar;203(3):1539-1554
Highly expressed VGLL3 in keloid fibroblasts promotes glycolysis and collagen production via the activation of Wnt/β-catenin signaling.
Liu Y, Yang Z, Lin N, Liu Y, Chen H
Cellular signalling 2025 Mar;127:111604
Cellular signalling 2025 Mar;127:111604
Silencing long non-coding RNA linc00689 suppresses the growth and invasion of osteosarcoma cells by targeting miR-129-5p/NUSAP1.
Zhang L, Song J, Xu X, Sun D, Huang H, Chen Y, Zhang T
International journal of experimental pathology 2025 Mar;106(2):e12524
International journal of experimental pathology 2025 Mar;106(2):e12524
VHL ameliorates arecoline-induced oral submucosal fibrosis by promoting HDAC6 ubiquitination and blocking NF-κB pathway.
Sun H, Yang C, Yin X, Chen S, Huang Y, Kuang H, Luo W
Scientific reports 2025 Mar 4;15(1):7563
Scientific reports 2025 Mar 4;15(1):7563
Characterization of Protein Expression and Signaling Pathway Activation That May Contribute to Differential Biological Functions in Porcine Arterial and Venous Smooth Muscle Cells.
Arteaga EC, Wai C, Uriyanghai U, Rudraraju M, Su H, Sudarsanam VA, Haddad SO, Poulton JS, Roy-Chaudhury P, Xi G
International journal of molecular sciences 2025 Mar 28;26(7)
International journal of molecular sciences 2025 Mar 28;26(7)
Cyanidin-3-glucoside upregulated NDRG2 through the PI3K/AKT pathway to alleviate EMT and ECM in renal fibrosis.
Lu Q, Liu J, Xiong Y, Jian J, Wang J, Chen Z, Wan S, Liu X, Wang L
Scientific reports 2025 Mar 28;15(1):10695
Scientific reports 2025 Mar 28;15(1):10695
Targeted Degradation of Bromodomain-Containing Protein 4 Enabled by Reactive Oxygen Species-Activatable NanoPROTACs as an Efficient Strategy to Reverse Liver Fibrosis in Chronic Liver Injury.
Bi T, Liang P, Zhao Q, Wu J, Zhou Y, Xu Y, Fan X, Yang G, Sun Q, Ren W, Yang Y, Liu Z
Journal of medicinal chemistry 2025 Mar 27;68(6):6328-6338
Journal of medicinal chemistry 2025 Mar 27;68(6):6328-6338
MDA5 protein mediating persistent ER stress/unfolded protein response contributes to endothelial-mesenchymal-transition of lung microvascular endothelial cell in dermatomyositis.
Zhao LQ, Yang XQ, Niu Q, Feng X, Zhang HD, Ye SY, Jiang LJ, Yu F, Ye H, Ma WL
Cell communication and signaling : CCS 2025 Mar 23;23(1):149
Cell communication and signaling : CCS 2025 Mar 23;23(1):149
PPDPF preserves integrity of proximal tubule by modulating NMNAT activity in chronic kidney diseases.
Fang X, Zhong Y, Zheng R, Wu Q, Liu Y, Zhang D, Wang Y, Ding W, Wang K, Zhong F, Lin K, Yao X, Hu Q, Li X, Xu G, Liu N, Nie J, Li D, Geng H, Guan Y
Science advances 2025 Mar 21;11(12):eadr8648
Science advances 2025 Mar 21;11(12):eadr8648
Polo-like kinase2 regulates renal tubulointerstitial fibrosis via notch signaling pathway in diabetic kidney disease.
Luo J, Xu H, Su C, Dong W, Xiao M, Xiao N, Jia Y, Xue Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Mar 15;39(5):e70455
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Mar 15;39(5):e70455
Expression of ENL YEATS domain tumor mutations in nephrogenic or stromal lineage impairs kidney development.
Xue Z, Xuan H, Lau K, Su Y, Wegener M, Li K, Turner L, Adams M, Shi X, Wen H
Nature communications 2025 Mar 14;16(1):2531
Nature communications 2025 Mar 14;16(1):2531
Daidzein alleviates skin fibrosis by suppressing TGF-β1 signaling pathway via targeting PKM2.
Guo X, Li W, Ma W, Liu Y, Liu Z, Jiao R, Yang Z, Zhang T, Wu H, Ai X, Gu X, Wang W, Zhou H, Li X, Yang C
Scientific reports 2025 Mar 13;15(1):8649
Scientific reports 2025 Mar 13;15(1):8649
Astilbin Alleviates Radiation-Induced Pulmonary Fibrosis via circPRKCE Targeting the TGF-β/Smad7 Pathway to Inhibit Epithelial-Mesenchymal Transition.
Shi Z, Liu J, Qin J, Liang X, Ou X, Zhang T, Yan X, Hu Q, Huang W, Hu K
Biomedicines 2025 Mar 11;13(3)
Biomedicines 2025 Mar 11;13(3)
Modulation of the Epithelial-mesenchymal transition process by Forkhead Box C2 in the repair of airway epithelium after injury.
Wang Y, Liu J
Respiratory research 2025 Mar 10;26(1):96
Respiratory research 2025 Mar 10;26(1):96
Trimethylamine oxide promotes myocardial fibrosis through activating JAK2-STAT3 pathway.
Yang X, Wang Y, Feng Y, Wang F, Gao L, Wang Y
Biochemical and biophysical research communications 2025 Mar 1;750:151390
Biochemical and biophysical research communications 2025 Mar 1;750:151390
FBXW7 mediates high glucose-induced epithelial to mesenchymal transition via KLF5 in renal tubular cells of diabetic kidney disease.
Li J, Jia K, Wang W, Pang Y, Wang H, Hao J, Zhao D, Li F
Tissue & cell 2025 Jun;94:102801
Tissue & cell 2025 Jun;94:102801
Bushen Tongluo recipe improves oxidative stress homeostasis, inhibits transforming growth factor/Notch signaling pathway, and regulates the lncRNA maternally expressed gene 3/miR-145 axis to delay diabetic kidney disease.
Bojun XU, Tian T, Liangbin Z, Hui Z, Huakui Z, Julan G
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2025 Jun;45(3):561-570
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2025 Jun;45(3):561-570
SRSF7 promotes pulmonary fibrosis through regulating PKM alternative splicing in lung fibroblasts.
Jin T, Gao H, Wang Y, Ning Z, Bing D, Wang Y, Chen Y, Tian X, Liu Q, Niu Z, Guo J, Sun J, Yang R, Wang Q, Li S, Li T, Zhou Y, He W, Lu Y, Gu Y, Liang H
Acta pharmaceutica Sinica. B 2025 Jun;15(6):3041-3058
Acta pharmaceutica Sinica. B 2025 Jun;15(6):3041-3058
In Vivo Reprogramming of Tissue-Derived Extracellular Vesicles for Treating Chronic Tissue Injury Through Metabolic Engineering.
Zhao M, Liu S, Wang Y, Lou P, Lv K, Wu T, Li L, Wu Q, Zhu J, Lu Y, Wan M, Liu J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(21):e2415556
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(21):e2415556
Argan Callus Extract Restores Skin Cells via AMPK-Dependent Regulation of Energy Metabolism, Autophagy, and Inflammatory Pathways.
Hartinger R, Fenzl FQ, Nalewaja VM, Djabali K
Antioxidants (Basel, Switzerland) 2025 Jun 28;14(7)
Antioxidants (Basel, Switzerland) 2025 Jun 28;14(7)
Heshuxiaoji pill suppresses steatohepatitis and fibrosis by regulating the AngII-BACH1 mediated vasoconstriction.
Pu Y, Ren W, Gan Z, Wang S, Peng M, Yue R, Huang R
Journal of ethnopharmacology 2025 Jun 26;350:119989
Journal of ethnopharmacology 2025 Jun 26;350:119989
Notch3 enhances the synergistic effect of all-trans retinoic acid and calcipotriol in pancreatic stellate cell activation.
Lian Z, Du WH, Tusup-Han PG, Zhang YX
Journal of translational medicine 2025 Jun 22;23(1):694
Journal of translational medicine 2025 Jun 22;23(1):694
Ancestry-linked stromal variations impact breast epithelial cell invasion.
Schmidtmann MG, Elliott V, Clancy JW, Schafer ZT, Nakshatri H, D'Souza-Schorey C
iScience 2025 Jun 20;28(6):112686
iScience 2025 Jun 20;28(6):112686
Lenalidomide attenuates cardiac fibrosis and inflammation induced by β-adrenergic receptor activation.
Jiao R, Li W, Gu X, Liu J, Liu Z, Hu Y, Yang Z, Liu Y, Liu X, Gu R, Li L, Li X
International immunopharmacology 2025 Jun 17;158:114848
International immunopharmacology 2025 Jun 17;158:114848
Nobiletin from Citrus reticulata Blanco alleviates pulmonary fibrosis through inhibiting the PI3K/AKT pathway and epithelial-mesenchymal transition.
Yu S, Liu K, Zhou F, Yang X, Zhang J, Yu K, Zhu Y, Qin L, Peng T, Zhang C, He Y
Journal of ethnopharmacology 2025 Jun 12;349:119965
Journal of ethnopharmacology 2025 Jun 12;349:119965
Targeted Knockdown of Epithelial Estrogen Receptor α to Mitigate Ferroptosis and Epithelial-Mesenchymal Transition in Eosinophilic Asthma.
Zhang W, Zhang S, Hua L, Bai W, Qin L, Yue J, Wang D, Guo M, Wang X, Renz H, Chrysanthi S, Wang G, Chen Z, Dong H, Xie M
ACS nano 2025 Jun 10;19(22):21105-21117
ACS nano 2025 Jun 10;19(22):21105-21117
RGD peptide hydrogel downregulates mechanosignal YAP to inhibit postoperative scarring.
Lv Y, Liang L, Qin M, Jiang RP, Zong FF, Wu X, Wu KL, Liang L
Acta biomaterialia 2025 Jun 1;199:132-141
Acta biomaterialia 2025 Jun 1;199:132-141
TCF7 functions as a prognostic biomarker in bladder cancer by strengthening EMT and stemness associated with TGF-β/SMAD3 signaling.
Zhang C, Cai H, Ye M, Wang L, Liu W, Huang Q, Peng X, Mao G, Zhang Q, Mei Y
Molecular and cellular biochemistry 2025 Jul;480(7):4135-4148
Molecular and cellular biochemistry 2025 Jul;480(7):4135-4148
Fibroblast Activation Protein (FAP)(+) cancer-associated fibroblasts induce macrophage M2-like polarization via the Fibronectin 1-Integrin α5β1 axis in breast cancer.
Chen W, Jiang M, Zou X, Chen Z, Shen L, Hu J, Kong M, Huang J, Ni C, Xia W
Oncogene 2025 Jul;44(28):2396-2412
Oncogene 2025 Jul;44(28):2396-2412
Blocking TSP1 Ameliorates Diabetes Mellitus-Induced Erectile Dysfunction by Inhibiting the TGF-β/SMAD Pathway.
Xia M, Yuan Y, Fang D, Tan X, Zhao F, Li X, Gao P, Zhou Z, Nan T, Xin Z, Li X, Guan R
The world journal of men's health 2025 Jul;43(3):580-594
The world journal of men's health 2025 Jul;43(3):580-594
Linaggrenoids A-I, structurally diverse lindenane sesquiterpenoids with anti-hepatic fibrosis effects from Lindera aggregata.
Li WX, Gan L, Liao YL, Wu YW, Zhang BH, Guo DA, Li W
Phytochemistry 2025 Jul;235:114477
Phytochemistry 2025 Jul;235:114477
A-485 alleviates fibrosis and apoptosis in kidney by disrupting tandem activation of acetylation and phosphorylation on STAT3.
Du C, Zhu Y, Duan J, Yang Y, Ren Y, Mu L, Yan Z, Li G, Wang H, Shi Y, Yao F
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Jul;188:118217
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Jul;188:118217
Stiffness regulates extracellular matrix synthesis in fibroblasts by DDR1-TGF-β/STAT3 mechanotransduction axis.
Han X, Zhang C, Lei Q, Xu J, Zhou Y
Biomaterials advances 2025 Jul;172:214240
Biomaterials advances 2025 Jul;172:214240
Cytoplasmic and nuclear NFATc3 cooperatively contributes to vascular smooth muscle cell dysfunction and drives aortic aneurysm and dissection.
Liu X, Zhao L, Liu D, Zhao L, Tuo Y, Peng Q, Huang F, Song Z, Niu C, He X, Xu Y, Wan J, Zhu P, Jian Z, Guo J, Liu Y, Lu J, Liang S, Zheng S
Acta pharmaceutica Sinica. B 2025 Jul;15(7):3663-3684
Acta pharmaceutica Sinica. B 2025 Jul;15(7):3663-3684
The KSR1/MEK/ERK signaling pathway promotes the progression of intrauterine adhesions.
Wu S, Chen Q, Yang X, Zhang L, Huang X, Huang J, Wu J, Sun C, Zhang W, Wang J
Cellular signalling 2025 Jul;131:111730
Cellular signalling 2025 Jul;131:111730
Benzothiazole amide analogues as antagonists of TRPC 6 channels: A therapeutic approach for kidney fibrosis.
Ren C, Xu Q, Luo Q, Qiao X, Ding T, Wang W, Zeng X, Chen C, Xiao Y, Hong X
European journal of medicinal chemistry 2025 Jul 5;291:117628
European journal of medicinal chemistry 2025 Jul 5;291:117628
Recombinant Human Annexin A5 Ameliorates Localized Scleroderma by Inhibiting the Activation of Fibroblasts and Macrophages.
Kang B, Jia Z, Li W, Zhang W
Pharmaceutics 2025 Jul 30;17(8)
Pharmaceutics 2025 Jul 30;17(8)
Pantothenic acid ameliorates hepatic fibrosis by targeting IGFBP6 to regulate the TGF-β/SMADs pathway.
Jin Z, Jin Z, Liu Z, Yin Y, Zhang Y, Zhang Y, Kang J, Fang Y, Jiang W, Ning B
Communications biology 2025 Jul 29;8(1):1127
Communications biology 2025 Jul 29;8(1):1127
Mefunidone treats pulmonary fibrosis by targeting SDH to regulate fibro-promoting macrophages.
Zhang X, He Y, Long L, Jiang G, Yao T, Cheng X, Peng Z, Hu G, Tao L, Meng J
International immunopharmacology 2025 Jul 28;160:114971
International immunopharmacology 2025 Jul 28;160:114971
Wikstdaphnoids A-I, Daphnane Diterpenoid Orthoesters from Wikstroemia chamaedaphne with Anti-Liver Fibrosis Activity.
Huang D, Liao YL, Chen JQ, Yuan FY, Wu SQ, Huang JL, Yuan T, Chen X, Sun ZH, Tang GH, Gan L, Yin S
Journal of natural products 2025 Jul 25;88(7):1781-1790
Journal of natural products 2025 Jul 25;88(7):1781-1790
EphrinB2 alleviates tubulointerstitial fibrosis in diabetic kidney disease.
Ni L, Zhou Q, Gao X, Chen F, Yusufu A, Chen JH, Yuan C, Wu X
Journal of translational medicine 2025 Jul 24;23(1):821
Journal of translational medicine 2025 Jul 24;23(1):821
GSR Deficiency Exacerbates Oxidative Stress and Promotes Pulmonary Fibrosis.
Zhao W, Cao H, Xu W, Duan Y, Gan Y, Huang S, Cao Y, Long S, Zhang Y, Yu G, Wang L
Biomolecules 2025 Jul 20;15(7)
Biomolecules 2025 Jul 20;15(7)
Timosaponin AIII alleviates type 2 diabetes-induced cardiomyopathy by targeting galectin-3 (LGALS3).
Yin J, Yu C, Zhang Z, Cong J
Experimental cell research 2025 Jul 15;450(2):114665
Experimental cell research 2025 Jul 15;450(2):114665
Exploring PU.1 as a Therapeutic Target to Mitigate Oxidative Stress and Inflammation in Peritoneal Dialysis-Induced Peritoneal Fibrosis.
Zhong S, Su W, Wang Y, Liu D, Li X, Ma F, Xu L, Gao J, Wang H, Sun J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jul 15;39(13):e70766
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jul 15;39(13):e70766
Periostin mediates collagen production, ECM remodeling and myofibroblast differentiation in breast prosthesis capsule formation.
Yang Y, Li S, Bian L, Dai X, Hu J, Ma Y, Wang Z
Scientific reports 2025 Jul 15;15(1):25649
Scientific reports 2025 Jul 15;15(1):25649
Negative Air Ions Attenuate Nicotine-Induced Vascular Endothelial Dysfunction by Suppressing AP1-Mediated FN1 and SPP1.
Xiao S, Wei T, Xiao M, Shan M, An Z, Li N, Zhou J, Zhao S, Lu X
Antioxidants (Basel, Switzerland) 2025 Jul 14;14(7)
Antioxidants (Basel, Switzerland) 2025 Jul 14;14(7)
Identification and analysis of extracellular matrix and epithelial-mesenchymal transition-related genes in idiopathic pulmonary fibrosis by bioinformatics analysis and experimental validation.
Huang X, Yu W, Tian J, Zhang Y, Wei A, Li Y, Chen S
Gene 2025 Jul 10;956:149464
Gene 2025 Jul 10;956:149464
Epac1 Inhibits Orbital Fibroblast Activation to Ameliorate Thyroid-Associated Orbitopathy-Like Features Through the JAK/STAT Signaling Pathway.
Liu R, Xin X, Ma S, Guo J, Wu C, Qi X, Luo B
Investigative ophthalmology & visual science 2025 Jul 1;66(9):68
Investigative ophthalmology & visual science 2025 Jul 1;66(9):68
The miR-320a/PRDX3 Axis Alleviates the Oxidative Stress and Fibrotic Alterations in Fibroblasts in Thyroid Eye Disease.
Liu S, Yi J, Lu S, Cao J, Xie B, Tan Y, Xiong W
Investigative ophthalmology & visual science 2025 Jul 1;66(9):41
Investigative ophthalmology & visual science 2025 Jul 1;66(9):41
Comparison of the effects of Liraglutide, Tirzepatide, and Retatrutide on diabetic kidney disease in db/db mice.
Ma J, Hu X, Zhang W, Tao M, Wang M, Lu W
Endocrine 2025 Jan;87(1):159-169
Endocrine 2025 Jan;87(1):159-169
Cementum and enamel surface mimicry influences soft tissue cell behavior.
Bellon B, Pippenger B, Stähli A, Degen M, Parisi L
Journal of periodontal research 2025 Jan;60(1):64-76
Journal of periodontal research 2025 Jan;60(1):64-76
A polysaccharide from Glycyrrhiza uralensis attenuates myocardial fibrosis via modulating the MAPK/PI3K/AKT signaling pathway.
Niu P, Zhang X, Zhang G, Jing R, Qiao Y, Zhou X, Bai M, Peng L
International journal of biological macromolecules 2025 Jan;286:138207
International journal of biological macromolecules 2025 Jan;286:138207
Sympathetic nerve promotes renal fibrosis by activating M2 macrophages through β2-AR-Gsa.
Liu L, Deng Y, Li Q, Cai Y, Zhang C, Zhang T, Xu G, Han M
Clinical immunology (Orlando, Fla.) 2025 Jan;270:110397
Clinical immunology (Orlando, Fla.) 2025 Jan;270:110397
A natural small molecule alleviates liver fibrosis by targeting apolipoprotein L2.
Gan L, Jiang Q, Huang D, Wu X, Zhu X, Wang L, Xie W, Huang J, Fan R, Jing Y, Tang G, Li XD, Guo J, Yin S
Nature chemical biology 2025 Jan;21(1):80-90
Nature chemical biology 2025 Jan;21(1):80-90
Inhibition of PKM2 by shikonin impedes TGF-β1 expression by repressing histone lactylation to alleviate renal fibrosis.
Xiang T, Wang X, Huang S, Zhou K, Fei S, Zhou B, Yue K, Li Q, Xue S, Dai Y, Zhang J, Ni H, Sun C, Huang X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156324
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156324
Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection: A natural ingredient strategy.
Zhou X, Ma D, He YX, Jin J, Wang HL, Wang YF, Yang F, Liu JQ, Chen J, Li Z
World journal of gastroenterology 2025 Jan 7;31(1):98561
World journal of gastroenterology 2025 Jan 7;31(1):98561
Estrogen Receptor β Activation Mitigates Colitis-associated Intestinal Fibrosis via Inhibition of TGF-β/Smad and TLR4/MyD88/NF-κB Signaling Pathways.
Ling F, Chen Y, Li J, Xu M, Song G, Tu L, Wang H, Li S, Zhu L
Inflammatory bowel diseases 2025 Jan 6;31(1):11-27
Inflammatory bowel diseases 2025 Jan 6;31(1):11-27
Lichong decoction improves inflammatory microenvironment and alleviates fibrosis in uterine leiomyoma via targeting CXCL8.
Yang X, Chen Z, Qiu T, Liu Y, Ren H, Luo W, Zuo J, Li D
Journal of ethnopharmacology 2025 Jan 31;340:119276
Journal of ethnopharmacology 2025 Jan 31;340:119276
Baricitinib represses the myocardial fibrosis via blocking JAK/STAT and TGF-β1 pathways in vivo and in vitro.
Feng R, Liu H, Chen Y
BMC cardiovascular disorders 2025 Jan 31;25(1):65
BMC cardiovascular disorders 2025 Jan 31;25(1):65
iTRAQ-Based Proteomic Analysis of Spontaneous Achilles Tendon Rupture.
Qianman B, Jiasharete T, Badalihan A, Mamately A, Yeerbo N, Bahesutihan Y, Wupuer A, Aisaiding A, Wuerliebieke J, Jialihasi A, Li P, Jielile J
Journal of proteome research 2025 Jan 3;24(1):65-76
Journal of proteome research 2025 Jan 3;24(1):65-76
Trehalose enhances macrophage autophagy to promote myelin debris clearance after spinal cord injury.
Ma Z, Meng C, Wang X, Zhao Y, Wang J, Chen Y, Li Y, Jiang Y, Ouyang F, Li J, Zheng M, Cheng L, Jing J
Cell & bioscience 2025 Jan 29;15(1):11
Cell & bioscience 2025 Jan 29;15(1):11
Combined ADAMTS10 and ADAMTS17 inactivation exacerbates bone shortening and compromises extracellular matrix formation.
Taye N, Karoulias SZ, Balic Z, Wang LW, Willard BB, Martin D, Richard D, Okamoto AS, Capellini TD, Apte SS, Hubmacher D
bioRxiv : the preprint server for biology 2025 Jan 24;
bioRxiv : the preprint server for biology 2025 Jan 24;
Immunopathological characteristics and therapeutic effects of UC-MSCs in a pigeon breeder's lung mouse model.
Xu J, Li L, Zhou Y, Abudureheman Z, Xue L, Wu C, Zou X
Acta biochimica et biophysica Sinica 2025 Jan 21;57(3):473-485
Acta biochimica et biophysica Sinica 2025 Jan 21;57(3):473-485
FSTL1 aggravates high glucose-induced oxidative stress and transdifferentiation in HK-2 cells.
Zhang B, Geng H, Zhao K, Omorou M, Liu S, Ye Z, Zhang F, Luan H, Zhang X
Scientific reports 2025 Jan 2;15(1):434
Scientific reports 2025 Jan 2;15(1):434
FN1 shapes the behavior of papillary thyroid carcinoma through alternative splicing of EDB region.
Liu M, Chen P, Wei B, Tan HL, Zhao YX, Ai L, Li N, Jiang YK, Lin J, Li SJ, Chang S
Scientific reports 2025 Jan 2;15(1):327
Scientific reports 2025 Jan 2;15(1):327
Mechanism of hsa_circ_0069443 promoting early pregnancy loss through ALKBH5/FN1 axis in trophoblast cells.
Li BX, Wu MY, Wang ZH, Zhou DM, Li JQ, Lu BF, Lin XL, Zhao Y, Sheng XJ
iScience 2025 Jan 17;28(1):111608
iScience 2025 Jan 17;28(1):111608
Wenshen Xiaozheng Tang alleviates fibrosis in endometriosis by regulating differentiation and paracrine signaling of endometrium-derived mesenchymal stem cells.
Zhang Z, Zhou X, Xia L, Li N, Xu S, Dong X, Zhu L, Huang M, Wan G
Journal of ethnopharmacology 2025 Jan 10;336:118724
Journal of ethnopharmacology 2025 Jan 10;336:118724
Bleomycin pollution and lung health: The therapeutic potential of peimine in bleomycin-induced pulmonary fibrosis by inhibiting glycolysis.
Li K, Liu X, Lu R, Zhao P, Tian Y, Li J
Ecotoxicology and environmental safety 2025 Jan 1;289:117451
Ecotoxicology and environmental safety 2025 Jan 1;289:117451
Injectable agents for the induction of Peyronie's disease in model rats: a comparative study.
Du GJ, Xing SY, Wu N, Wang T, Jiang YH, Song T, Yang BB, Dai YT
Asian journal of andrology 2025 Jan 1;27(1):96-100
Asian journal of andrology 2025 Jan 1;27(1):96-100
Confrontation with kidney inflammation through a HMGB1-targeted peptide augments anti-fibrosis therapy.
Deng Y, Zhang T, Cai Y, Ke L, He X, Zhang C, Liu L, Li Q, Zhao Y, Xu G, Han M
Biochimica et biophysica acta. Molecular basis of disease 2025 Feb;1871(2):167586
Biochimica et biophysica acta. Molecular basis of disease 2025 Feb;1871(2):167586
A novel Cdc42-YAP-fibronectin signaling axis regulates ameloblast differentiation during early enamel formation.
Zhang J, Gao J, Zeng X, Wang Z, Chen C, Rong C, Li S, Cai L, Wang L, Zhang L, Tian Z
Biochimica et biophysica acta. Molecular basis of disease 2025 Feb;1871(2):167570
Biochimica et biophysica acta. Molecular basis of disease 2025 Feb;1871(2):167570
Asiatic acid improves the damage of HaCaT cells induced by nitrogen mustard through inhibiting endoplasmic reticulum stress.
Liu H, Cheng J, Ye F, Dong X, Ge W, Wang X, Zhao Y, Dan G, Chen M, Sai Y
Toxicology research 2025 Feb;14(1):tfaf019
Toxicology research 2025 Feb;14(1):tfaf019
Blockade of neddylation through targeted inhibition of DCN1 alleviates renal fibrosis.
Huo JL, Fu W, Feng Q, Pan S, Liu D, Liu Z
Clinical science (London, England : 1979) 2025 Feb 6;139(3):229-46
Clinical science (London, England : 1979) 2025 Feb 6;139(3):229-46
Spatial transcriptomic analysis of tumor microenvironment in esophageal squamous cell carcinoma with HIV infection.
Zuo Y, Jin Y, Li G, Ming Y, Fan T, Pan Y, Yao X, Peng Y
Molecular cancer 2025 Feb 25;24(1):54
Molecular cancer 2025 Feb 25;24(1):54
Succinate supplementation alleviates liver cancer by inhibiting the FN1/SQLE axis-mediated cholesterol biosynthesis.
Chang S, Tomii A, Zhou Y, Yang X, Dong Y, Yan J, Wu A, Wang Y, Zhang Q, Meng H, Yu L, Sun W, Liu D
iScience 2025 Feb 21;28(2):111731
iScience 2025 Feb 21;28(2):111731
Autocrine small extracellular vesicles induce tubular phenotypic transformation in diabetic nephropathy via miR-21-5p.
Zhang M, Lu Y, Wang L, Mao Y, Hu X, Chen Z
Gene 2025 Feb 20;938:149156
Gene 2025 Feb 20;938:149156
A glucose-enriched lung pre-metastatic niche triggered by matrix stiffness-tuned exosomal miRNAs in hepatocellular carcinoma.
Zhao Y, Yu H, Li J, Qian J, Li M, Zhang X, Wang M, Wang Y, Dong Y, You Y, Zhou Q, Gao D, Zhao Y, Liu B, Chen R, Ren Z, Wang Z, Zhang K, Cui J
Nature communications 2025 Feb 18;16(1):1736
Nature communications 2025 Feb 18;16(1):1736
IFN-γ-mediated inhibition of JAK/STAT signaling via nano-scutellarin treatment is an efficient strategy for ameliorating liver fibrosis.
Wang T, Liu B, Huang J, Zhao Q, Shen H, Bi T, Liu Z, Dai Y, Sun Q
Journal of translational medicine 2025 Feb 17;23(1):195
Journal of translational medicine 2025 Feb 17;23(1):195
Sulfonated albumin from hepatocytes accelerates liver fibrosis in nonalcoholic fatty liver disease through endoplasmic reticulum stress.
Liu T, Sui M, Tian M, Wu N, Zhao S, Wang Y, Yang Y, Ma S, Jiao D, Wang L, Feng Y, Zhang Y, Qin C, Liu C, Qi J, Zhu Q
Free radical biology & medicine 2025 Feb 16;228:150-162
Free radical biology & medicine 2025 Feb 16;228:150-162
Targeted approach to determine the impact of cancer-associated protease variants.
Bickenbach K, David N, Koudelka T, Joos C, Scharfenberg F, Rüffer M, Armbrust F, Georgiadis D, Beau F, Stahmer L, Rahn S, Tholey A, Pietrzik C, Becker-Pauly C
Science advances 2025 Feb 14;11(7):eadp5958
Science advances 2025 Feb 14;11(7):eadp5958
Miglustat ameliorates isoproterenol-induced cardiac fibrosis via targeting UGCG.
Liu J, Li W, Jiao R, Liu Z, Zhang T, Chai D, Meng L, Yang Z, Liu Y, Wu H, Gu X, Li X, Yang C
Molecular medicine (Cambridge, Mass.) 2025 Feb 11;31(1):55
Molecular medicine (Cambridge, Mass.) 2025 Feb 11;31(1):55
Recombinant Humanized Collagen Enhances Secreted Protein Levels of Fibroblasts and Facilitates Rats' Skin Basement Membrane Reinforcement.
Ye S, Chen B, Jeevithan L, Yang H, Kong Y, Diao X, Wu W
Journal of functional biomaterials 2025 Feb 1;16(2)
Journal of functional biomaterials 2025 Feb 1;16(2)
Combined ADAMTS10 and ADAMTS17 inactivation exacerbates bone shortening and skin phenotypes.
Taye N, Karoulias SZ, Balic Z, Wang LW, Willard BB, Martin D, Richard D, Okamoto AS, Capellini TD, Apte SS, Hubmacher D
Life science alliance 2025 Dec;8(12)
Life science alliance 2025 Dec;8(12)
PAI-1 deficiency inhibits endometrial fibrosis via modulation of the FAK/Src/ERK and AKT signalling pathways.
Zhao H, Wang X, Liu J, Yu M, Bao H
Reproductive biomedicine online 2025 Dec;51(6):105120
Reproductive biomedicine online 2025 Dec;51(6):105120
Panaxatriol saponins exert anti-renal fibrosis by suppressing TNF-α mediated inflammation and TGF-β1/Smad3 signaling pathway.
Yi S, Li F, Ma X, Xu Y, Lai W, Chen H, Fan J, Mao N, Ren S
Renal failure 2025 Dec;47(1):2516774
Renal failure 2025 Dec;47(1):2516774
Protective effect of phosphoenolpyruvate carboxykinase 1 on inflammation and fibrotic progression of IgA nephropathy.
Tan YY, Wang YK, Luo XM, Chen CY, Liu XQ, Liu XR, Wu YG
Renal failure 2025 Dec;47(1):2508297
Renal failure 2025 Dec;47(1):2508297
The role and mechanisms of the microRNA-1180-3p/MKNK2/CREB3 signaling axis in tumor progression following insufficient radiofrequency ablation of colorectal cancer liver metastasis.
Gao Y, Zhu J, Xin H, Ni B, Liu Z
Biochemical pharmacology 2025 Dec;242(Pt 3):117216
Biochemical pharmacology 2025 Dec;242(Pt 3):117216
The multifaceted modulations by dapagliflozin in preventing hyperglycemia-induced diabetic nephropathy through glucose transporters and PPARα.
Chung HH, Tseng CJ, Cheng PW
Journal of diabetes and metabolic disorders 2025 Dec;24(2):154
Journal of diabetes and metabolic disorders 2025 Dec;24(2):154
Stellarin I: A Bioactive Cyclic Nonapeptide with Potent Anti-renal Fibrosis Activity from the Root of Stellaria yunnanensis Franch.
Deng R, Gu C, Wang J, Li X, Xin X, Yang Y, Li J, Xia C, An F
Chemistry & biodiversity 2025 Dec;22(12):e02177
Chemistry & biodiversity 2025 Dec;22(12):e02177
Formononetin, a Key Component of Danggui Buxue Decoction, Inhibits Metastasis of Triple-Negative Breast Cancer by Modulating SNAI2-Driven EMT.
Li K, Zhou T, Wu R, Xiong J
Food science & nutrition 2025 Dec;13(12):e71286
Food science & nutrition 2025 Dec;13(12):e71286
Autophagy-dependent secretion of ENO1 mediates chemoresistance of glioblastoma and tumor microenvironment remodeling.
Xie Q, Chen L, Huang Y, Yu Z, Zhu R, Li J, Zhao J, Song Y, Li H, Lu Y
Cell death & disease 2025 Dec 6;17(1):79
Cell death & disease 2025 Dec 6;17(1):79
The novel circular RNA circG6pc attenuates oxidative stress and mitochondrial damage through miR-7018-5p/Aldh6a1 axis in kidney fibrosis.
Zhao X, Xiong Y, Qin X, Hu J, Huang S, Ni X, Jian J, Yang S, Weng X, Chen H, Chen Z, Liu X, Wang L
Cellular & molecular biology letters 2025 Dec 5;30(1):144
Cellular & molecular biology letters 2025 Dec 5;30(1):144
Neutrophil extracellular traps promote bone loss in type 1 diabetes via suppression of the FN1-PI3K/Akt signaling axis.
Liu X, Xiao D, Zhang D, Pan Y, Guo J, Zhang Y, Li S, Tang Q, Jin X, Sun T
International immunopharmacology 2025 Dec 3;166:115629
International immunopharmacology 2025 Dec 3;166:115629
Six1 promotes alveolar epithelium senescence in pulmonary fibrosis through regulating Tp53.
Fan Y, Tian Z, Zheng H, Xu R, Li B, Wang S, Huang Z, Wang M, Ding D, Zhao J, Xie J
International immunopharmacology 2025 Dec 3;166:115554
International immunopharmacology 2025 Dec 3;166:115554
The role and mechanism of ARRB1 in simulated space radiation and microgravity-induced lung carcinogenesis.
Xu Y, Ding Y, Pei W, Zhang M, Wang X, Zeng Q, Hei TK, Hu W, Zhou G
NPJ microgravity 2025 Dec 3;12(1):3
NPJ microgravity 2025 Dec 3;12(1):3
Sustained mesenchymal reprogramming of endothelial cells after completion of chemotherapy.
Sjostrom K, Tao S, Cobb MS, Landers S, Kwok A, Singh R, Shohet RV, Kibiryeva N, Konorev EA
Cardio-oncology (London, England) 2025 Dec 29;11(1):116
Cardio-oncology (London, England) 2025 Dec 29;11(1):116
Dual-functional nanovesicles simultaneously inhibit stromal fibrosis and angiogenesis to suppress cholangiocarcinoma progression.
Zhang L, Duan X, Shi Q, Yao X, Chen Q, Wan J, Wang F, Ni C, Li Y, Wang M, Sheng Y, Zheng W, Liu J, Ji T, Qin Z
Journal of nanobiotechnology 2025 Dec 22;23(1):781
Journal of nanobiotechnology 2025 Dec 22;23(1):781
High matrix stiffness triggers the YAP-OPA1-TET1/3 loop to drive chemoresistance via enhanced nuclear-mitochondrial communication.
Wu P, Wang S, Hu Z, Zhang H, Lin Y, Li Z, Wu J, Chen Y, Chen Y, Xu Y, Li J, Guan Y
iScience 2025 Dec 19;28(12):113996
iScience 2025 Dec 19;28(12):113996
Multi-omics factor analysis identifies the Tensin 1-Fermitin family homologue 2-Fibronectin 1-Integrin signaling axis as a prognostic determinant in colorectal cancer.
Chen T, Yang Y, Shi J, Dong F, Xie L, Shan Y, Wang X
Molecular biomedicine 2025 Dec 17;6(1):141
Molecular biomedicine 2025 Dec 17;6(1):141
NAT10-mediated N4-acetylcytidine (ac4C) modification of PIK3R2 mRNA promotes malignant progression of glioblastoma.
Meng X, Dong T, Xu J, Tian K, Yang W, Liu Z, Qian Y, Liu D, Chen C, Bai J, Yong H, Wu X, Shen Z
Cell death & disease 2025 Dec 17;17(1):106
Cell death & disease 2025 Dec 17;17(1):106
Fat-targeted small molecule alleviates abnormal adipose tissue remodeling in obesity via SIRT3-driven mitophagy and inflammasome inhibition.
Linghu K, Hu L, Wang YE, Zhou Y, Wang Y, Shi M, Liu L, Yu H, Tang L, Lin L, Guo B, Tian A, Zhang T
Chinese medicine 2025 Dec 10;20(1):215
Chinese medicine 2025 Dec 10;20(1):215
De-ubiquitinase USP35 promotes peritoneal dissemination of gastric cancer by regulating metabolic reprogramming.
Yan L, Chen M, Cai L, Liu A, Li F, Zhang Y, Peng X, Wang Y, Li R, Mei J, Zou D, Gao X, Wang Y, Wu L, Zhang Y
Cell death & disease 2025 Dec 10;16(1):889
Cell death & disease 2025 Dec 10;16(1):889
Uremic serum exposure leads to differential phenotypic switch in porcine arterial and venous smooth muscle cells.
Su H, Uriyanghai U, Wai C, Arteaga EC, Wan H, Adam KP, Sudarsanam VA, Haddad SO, Yang A, Li L, Bahnson EM, Poulton JS, Roy-Chaudhury P, Xi G
American journal of physiology. Renal physiology 2025 Dec 1;329(6):F809-F819
American journal of physiology. Renal physiology 2025 Dec 1;329(6):F809-F819
Cell Division Cycle 42 Improves Renal Functions, Fibrosis, Th1/Th17 Infiltration and Inflammation to Some Degree in Diabetic Nephropathy.
Zhao N, Feng C, Zhang Y, Chen H, Ma J
Inflammation 2025 Aug;48(4):1987-1997
Inflammation 2025 Aug;48(4):1987-1997
Nerandomilast Improves Bleomycin-Induced Systemic Sclerosis-Associated Interstitial Lung Disease in Mice by Regulating the TGF-β1 Pathway.
Liu Y, Liu Z, Li X, Li W, Yang Z, Jiao R, Wang Q, Meng L, Zhang T, Liu J, Chai D, Zhang N, Peng S, Zhou H, Yang C
Inflammation 2025 Aug;48(4):1760-1774
Inflammation 2025 Aug;48(4):1760-1774
Reprogramming peritoneal macrophages with outer membrane vesicle-coated PLGA nanoparticles for endometriosis prevention.
Wu N, Han Z, Lv W, Huang Y, Zhu J, Deng J, Xue Q
Biomaterials 2025 Aug;319:123198
Biomaterials 2025 Aug;319:123198
Role of UVA-driven cellular senescence via mTOR activation in dihydrotestosterone-induced hair loss in androgenetic alopecia mouse model.
Wei D, Zhang H, Xu W, Zhang B, Zhang L, Lan L, Li Y, Shi Y, Song X
Journal of photochemistry and photobiology. B, Biology 2025 Aug;269:113200
Journal of photochemistry and photobiology. B, Biology 2025 Aug;269:113200
Revealing a new target: Celastrol alleviates pulmonary fibrosis by inhibiting PCAF.
Wang L, Lin F, Liu J, Jia Z, Zhu M, Liu Y, Li Y, Yang L
Bioorganic chemistry 2025 Aug;163:108722
Bioorganic chemistry 2025 Aug;163:108722
Curdione inhibits the proliferation of human uterine leiomyomas by targeting YTHDF1.
Yang X, Zuo J, Qiu T, Ren H, Qian R, Luo W, Chen Z, Li D
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Aug;144:156938
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Aug;144:156938
F-box only protein 10 protects against kidney tubulointerstitial fibrosis by inhibiting ACSL4-mediated lipid peroxidation and ferroptosis.
Hu J, Ma F, Chen X, Lu X, Lu Y, Jiang Y
Cellular signalling 2025 Aug;132:111841
Cellular signalling 2025 Aug;132:111841
Rehmannioside A alleviates renal inflammation and fibrosis in hypertensive nephropathy via AT1R/MAPK14/IL-17 signaling pathway.
Liu F, Wang J, Sun Z, Yu X
Biochemical and biophysical research communications 2025 Aug 30;776:152237
Biochemical and biophysical research communications 2025 Aug 30;776:152237
Assessments of neurogenic bladder dysfunction induced by spinal cord injury, bladder outlet obstruction and diabetes: a comparative study of rat models.
Sun S, Zhang J, Ainiwaer A, Liu Y, Shen D, Jiang Y, Chen H, Bohetiyaer A, Wu T, Gao Y, Li W, Xu Y, Xu T, Yan Y
Translational andrology and urology 2025 Aug 30;14(8):2254-2268
Translational andrology and urology 2025 Aug 30;14(8):2254-2268
Kurarinone protects against renal injury and fibrosis after unilateral ureteral obstruction through enhancement of the Nrf-2 signaling pathway.
Dong T, Zhao D, Jiang S, Gu Y, Wang C, Yang Q, Liu T, Liu X
Journal of molecular histology 2025 Aug 29;56(5):286
Journal of molecular histology 2025 Aug 29;56(5):286
S100a8 inhibitor Paquinimod attenuates coal dust-induced pulmonary fibrosis via blocking neutrophils-S100a8-Tlr4-macrophages signaling axis.
Du M, Hu S, Cao W, Li B, Jin H, Wang F, Yan R, Li X, Xie Z, Zou Y, Tao X, Wang W, Li Y, Mu M
International immunopharmacology 2025 Aug 28;161:115020
International immunopharmacology 2025 Aug 28;161:115020
Low-protein Calorie-restriction Mitigates Diabetic Mice Kidney Injury via the Gut-Kidney Axis.
Zhang R, Wei X, Xu Y, Han C, Cai X, Wu Y, Geng Y, Liu C
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 2025 Aug 27;95(4):37311
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 2025 Aug 27;95(4):37311
MSC-derived exosomes improve endometrial fibrosis via the lncRNA IGF2R/ miR-143-5p/AQP8 axis.
Huo X, Chen J, Qian M, Xue Q, Xu P, Wang Y, Jiang Z, Luo Q, Xiong Y
Stem cell research & therapy 2025 Aug 27;16(1):464
Stem cell research & therapy 2025 Aug 27;16(1):464
[Haematococcus pluvialis alleviates bleomycin-induced pulmonary fibrosis in mice by inhibiting transformation of lung fibroblasts into myofibroblast].
Zhang X, Man J, Zhang Y, Zheng Y, Wang H, Yuan Y, Xie X
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2025 Aug 20;45(8):1672-1681
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2025 Aug 20;45(8):1672-1681
Nintedanib inhibits neovascularization and subretinal fibrosis in a laser-induced choroidal neovascularization mouse model.
Qin S, Zhu Y, Liu Y, Xie H, Zhang J, Zhang C, Xu G
Biochemical and biophysical research communications 2025 Aug 15;775:152169
Biochemical and biophysical research communications 2025 Aug 15;775:152169
NAT10 Mediates Cardiac Fibrosis Induced by Myocardial Infarction Through ac4C Modification of TGFBR1 mRNA.
Zhou J, Chen Y, Chen J, Xia G, Zeng J, Wang L
Cell biology and toxicology 2025 Aug 12;41(1):125
Cell biology and toxicology 2025 Aug 12;41(1):125
Ergosterol from edible fungi: Enhancing fatty acid oxidation via CPT1A to protect against diabetic kidney disease.
Dong Z, Li X, Wang X, Xu J, Xu W
Food & function 2025 Aug 11;16(16):6599-6611
Food & function 2025 Aug 11;16(16):6599-6611
TGF-β1 induces ROS to activate ferroptosis via the ERK1/2-WISP1 pathway to promote the progression of renal tubular epithelial cell fibrosis.
Zhou Y, Luan F, Feng X, Yu M, Li L, Guo X, Yin X
Cytotechnology 2025 Apr;77(2):61
Cytotechnology 2025 Apr;77(2):61
Inhibition of bone morphogenetic protein 4 alleviates angiotensin II-induced abdominal aortic aneurysm by reducing inflammation and endothelial-mesenchymal transition.
Weng Y, Wang X, Tang Y, Du C, Li X, Zhu K, Bao Y, Zeng W, Cai C, Jia B, Yang Z, Tang L
Atherosclerosis 2025 Apr;403:119134
Atherosclerosis 2025 Apr;403:119134
Recombinant Humanized Collagen: A Promising Treatment for Pelvic Organ Prolapse via Enhanced Fibroblast Function and Angiogenesis.
Zhang Y, Li Y, Wu X, Wang S, Wei X, Sun X
International urogynecology journal 2025 Apr;36(4):881-893
International urogynecology journal 2025 Apr;36(4):881-893
CIP2A promotes bronchiolitis obliterans by activating the NF‑κB pathway.
Zhou X, Zhao X, Li Y, Zhang B
Molecular medicine reports 2025 Apr;31(4)
Molecular medicine reports 2025 Apr;31(4)
HDAC3 and Snail2 complex promotes melanoma metastasis by epigenetic repression of IGFBP3.
Wu N, Sun Q, Yang L, Sun H, Zhou Z, Hu Q, Li C, Wang D, Zhang L, Hu Y, Cong X
International journal of biological macromolecules 2025 Apr;300:140310
International journal of biological macromolecules 2025 Apr;300:140310
Pinocembrin alleviates renal ischemia-reperfusion injury/unilateral ureteral obstruction (UUO)-generated renal fibrosis by targeting the CYP1B1/ROS/MAPK axis.
Zhang BH, Chen H, Yang R, Jiang Z, Huang S, Chen Z, Liu C, Wang L, Liu XH
The FEBS journal 2025 Apr;292(8):2119-2144
The FEBS journal 2025 Apr;292(8):2119-2144
GABP Promotes Mesangial Cell Proliferation and Renal Fibrosis Through GLI1 in Diabetic Nephropathy.
Du L, Liu S, Lu Y, Ren D, Yu X, Hu Y, Yang T, Yang Q, Ming J, Zhang J, Yin X, Lu Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(15):e2407462
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(15):e2407462
Deletion of Pyruvate Carboxylase in Tubular Epithelial Cell Promotes Renal Fibrosis by Regulating SQOR/cGAS/STING-Mediated Glycolysis.
Huang H, Han Y, Zhang Y, Zeng J, He X, Cheng J, Wang S, Xiong Y, Yin H, Yuan Q, Huang L, Xie Y, Meng J, Tao L, Peng Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(13):e2408753
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(13):e2408753
Mechanism of Mitophagy to Protect Yak Kidney from Hypoxia-Induced Fibrosis Damage by Regulating Ferroptosis Pathway.
Bai X, Lu H, Ma R, Yu S, Yang S, He J, Cui Y
Biomolecules 2025 Apr 9;15(4)
Biomolecules 2025 Apr 9;15(4)
AMPK is dispensable for physiological podocyte and glomerular functions but prevents glomerular fibrosis in experimental diabetes.
Srivastava SP, Kopasz-Gemmen O, Kunamneni A, Thurnman A, Ozukan E, Swaroop V, Yoshida S, Hong S, Inoki K
bioRxiv : the preprint server for biology 2025 Apr 8;
bioRxiv : the preprint server for biology 2025 Apr 8;
Cancer-associated fibroblasts secrete CSF3 to promote TNBC progression via enhancing PGM2L1-dependent glycolysis reprogramming.
Qin W, Chen B, Li X, Zhao W, Wang L, Zhang N, Wang X, Luo D, Liang Y, Li Y, Chen X, Chen T, Yang Q
Cell death & disease 2025 Apr 4;16(1):249
Cell death & disease 2025 Apr 4;16(1):249
LncRNA-5829: a novel inhibitor of cardiac fibrosis.
Zhang X, Du Y, Xu J, Zhang W, Wen X, Zhou T, Hong H, Cheng R, Zhang R
Cardiovascular diagnosis and therapy 2025 Apr 30;15(2):302-317
Cardiovascular diagnosis and therapy 2025 Apr 30;15(2):302-317
Cathepsin B promotes optic nerve axonal regeneration.
Zhang S, Zhu H, Li G, Zhu M
Neuroreport 2025 Apr 2;36(6):279-289
Neuroreport 2025 Apr 2;36(6):279-289
MicroRNA-122-5p is upregulated in diabetic foot ulcers and decelerates the transition from the inflammatory to the proliferative stage.
Yuan MJ, Huang HC, Shi HS, Hu XM, Zhao Z, Chen YQ, Fan WJ, Sun J, Liu GB
World journal of diabetes 2025 Apr 15;16(4):100113
World journal of diabetes 2025 Apr 15;16(4):100113
Dehydrocorydaline attenuates bleomycin-induced pulmonary fibrosis by inhibiting fibroblast activation.
He J, Yue H, Zhang S, Dong R, Zhang F, Wang X, Wang K, Zhang H, Yang D, Dong Z, Liu H
Respiratory research 2025 Apr 12;26(1):136
Respiratory research 2025 Apr 12;26(1):136
Inhibition of Rho GEFs attenuates pulmonary fibrosis through suppressing myofibroblast activation and reprogramming profibrotic macrophages.
Luo C, Huang C, Zhu Y, Zhou Y, Qiao Y, Shi C, Gao Y, Guo Y, Wei L
Cell death & disease 2025 Apr 11;16(1):278
Cell death & disease 2025 Apr 11;16(1):278
NELL2, a novel osteoinductive factor, regulates osteoblast differentiation and bone homeostasis through fibronectin 1/integrin-mediated FAK/AKT signaling.
Yuan H, Wang X, Du S, Li M, Zhu E, Zhou J, Dong Y, Wang S, Shan L, Liu Q, Wang B
Bone research 2025 Apr 11;13(1):46
Bone research 2025 Apr 11;13(1):46
The CD163 + tissue-infiltrating macrophages regulate ferroptosis in thyroid-associated ophthalmopathy orbital fibroblasts via the TGF-β/Smad2/3 signaling pathway.
Li X, Wang S, Cao H, Xu S, Xiong C, Yu J, Chen Y, Ren Z, Li M, Hu Y, Gan P, Xu Q, Wang Y, Liao H
Journal of translational medicine 2025 Apr 10;23(1):423
Journal of translational medicine 2025 Apr 10;23(1):423
Proliferator-Activated Receptor Alpha Inhibits Abnormal Extracellular Matrix Accumulation and Maintains Energy Metabolism in Late-Onset Fuchs Endothelial Corneal Dystrophy.
Li X, Liu A, Zhou Y, Qi H, Wang J, Chen M, Sun T, Wu J, Huang Y, Wang L
Investigative ophthalmology & visual science 2025 Apr 1;66(4):36
Investigative ophthalmology & visual science 2025 Apr 1;66(4):36
Spatial Regulation of Cancer-Associated Fibroblasts and Tumor Cells via pH-Responsive Bispecific Antibody Delivery for Enhanced Chemo-Immunotherapy Synergy.
Liu H, Yong T, Zhang X, Wei Z, Bie N, Xu S, Zhang X, Li S, Zhang J, Zhou P, Yang X, Gan L
ACS nano 2025 Apr 1;19(12):11756-11773
ACS nano 2025 Apr 1;19(12):11756-11773
Astragaloside I from Astragalus Attenuates Diabetic Kidney Disease by Regulating HDAC3/Klotho/TGF-β1 Loop.
Zhang X, Wang J, Xiang S, Zhao L, Lv M, Duan Y, Gao G, Wang P, Jie Chen J, Xu J, Xie Z, Zhang Z
The American journal of Chinese medicine 2024;52(6):1795-1817
The American journal of Chinese medicine 2024;52(6):1795-1817
Expression and Clinicopathological Significance of Extracellular Matrix Remodeling Markers in Esophageal Squamous Carcinoma.
Fan Z, Chen F, Liu Y, Huang X, Tian S, Ma Y
Critical reviews in eukaryotic gene expression 2024;34(6):71-78
Critical reviews in eukaryotic gene expression 2024;34(6):71-78
An In Situ Sustained-Release Chitosan Hydrogel to Attenuate Renal Fibrosis by Retaining Klotho Expression.
Li C, Wang S, Liao C, Li Y, Zhou Y, Wu H, Xiong W
Biomaterials research 2024;28:0099
Biomaterials research 2024;28:0099
PTPLAD1 Regulates PHB-Raf Interaction to Orchestrate Epithelial-Mesenchymal and Mitofusion-Fission Transitions in Colorectal Cancer.
Huang ZJ, Li YJ, Yang J, Huang L, Zhao Q, Lu YF, Hu Y, Zhang WX, Liang JZ, Pan J, Pan YL, He QY, Wang Y
International journal of biological sciences 2024;20(6):2202-2218
International journal of biological sciences 2024;20(6):2202-2218
Lysozyme promotes renal fibrosis through the JAK/STAT3 signal pathway in diabetic nephropathy.
Ren Y, Yu M, Zheng D, He W, Jin J
Archives of medical science : AMS 2024;20(1):233-247
Archives of medical science : AMS 2024;20(1):233-247
Highly Ordered Nanotube-Like Microstructure on Titanium Dental Implant Surface Fabricated via Anodization Enhanced Cell Adhesion and Migration of Human Gingival Fibroblasts.
Deng Z, Yu L, Kuang Y, Zhou Z, Li X
International journal of nanomedicine 2024;19:2469-2485
International journal of nanomedicine 2024;19:2469-2485
Targeting transcription factor pu.1 for improving neurologic outcomes after spinal cord injury.
Shi Y, Zheng M, Luo Y, Li J, Ouyang F, Zhao Y, Wang J, Ma Z, Meng C, Bi Y, Cheng L, Jing J
Frontiers in neuroscience 2024;18:1418615
Frontiers in neuroscience 2024;18:1418615
Bone morphogenetic protein-6 suppresses TGF-β(2)-induced epithelial-mesenchymal transition in retinal pigment epithelium.
Liu X, Liu M, Ji M, Ma B, Hou YC, Yao XY, Cheng QC, Chen L
International journal of ophthalmology 2024;17(4):646-652
International journal of ophthalmology 2024;17(4):646-652
MicroRNA-204-5p Ameliorates Renal Injury via Regulating Keap1/Nrf2 Pathway in Diabetic Kidney Disease.
Dong J, Liu M, Bian Y, Zhang W, Yuan C, Wang D, Zhou Z, Li Y, Shi Y
Diabetes, metabolic syndrome and obesity : targets and therapy 2024;17:75-92
Diabetes, metabolic syndrome and obesity : targets and therapy 2024;17:75-92
ETS1 Expression in Diabetic Foot Ulcers: Implications for Fibroblast Phenotype and Wound Healing Through the PP2A/YAP Pathway.
Yi W, Bao Q, Xu D, Long C, Fang R, Cheng W, Song J, Feng H
Journal of inflammation research 2024;17:7373-7388
Journal of inflammation research 2024;17:7373-7388
Identification and verification of the optimal feature genes of ferroptosis in thyroid-associated orbitopathy.
Li X, Xiong C, Wang S, Ren Z, Jin Q, Yu J, Chen Y, Gan P, Xu Q, Wang Y, Liao H
Frontiers in immunology 2024;15:1422497
Frontiers in immunology 2024;15:1422497
Acute exposure to ultraviolet radiation targets proteins involved in collagen fibrillogenesis.
Platt CI, Stewart-McGuinness C, Eckersley A, Wilkins L, Sherratt MJ
Frontiers in physiology 2024;15:1352161
Frontiers in physiology 2024;15:1352161
Quantitative proteomics reveals the protective effects of Yinchenzhufu decoction against cholestatic liver fibrosis in mice by inhibiting the PDGFRβ/PI3K/AKT pathway.
Meng Q, Zhu H, Li Y, Peng X, Wang T, Huang H, Zhou H, Liu Y, Ru S, Wu J, Ma Y
Frontiers in pharmacology 2024;15:1341020
Frontiers in pharmacology 2024;15:1341020
Nicotinamide phosphoribosyltransferase prompts bleomycin-induced pulmonary fibrosis by driving macrophage M2 polarization in mice.
Chen Y, Wang T, Liang F, Han J, Lou Z, Yu Y, Li J, Zhan T, Gu Y, Dong L, Jiang B, Zhang W, Wu M, Lu Y
Theranostics 2024;14(7):2794-2815
Theranostics 2024;14(7):2794-2815
Abnormal mitochondrial iron metabolism damages alveolar type II epithelial cells involved in bleomycin-induced pulmonary fibrosis.
Shao M, Cheng H, Li X, Qiu Y, Zhang Y, Chang Y, Fu J, Shen M, Xu X, Feng D, Han Y, Yue S, Zhou Y, Luo Z
Theranostics 2024;14(7):2687-2705
Theranostics 2024;14(7):2687-2705
Vitamin D binding protein (VDBP) hijacks twist1 to inhibit vasculogenic mimicry in hepatocellular carcinoma.
Qin LN, Zhang H, Li QQ, Wu T, Cheng SB, Wang KW, Shi Y, Ren HR, Xing XW, Yang C, Sun T
Theranostics 2024;14(1):436-450
Theranostics 2024;14(1):436-450
ELMO1 ameliorates intestinal epithelial cellular senescence via SIRT1/p65 signaling in inflammatory bowel disease-related fibrosis.
Chen J, Li G, He X, Chen X, Chen Z, Liu D, Guo S, Huang T, Lin Y, Lan P, Lian L, He X
Gastroenterology report 2024;12:goae045
Gastroenterology report 2024;12:goae045
Mefunidone alleviates silica-induced inflammation and fibrosis by inhibiting the TLR4-NF-κB/MAPK pathway and attenuating pyroptosis in murine macrophages.
Long L, Dai X, Yao T, Zhang X, Jiang G, Cheng X, Jiang M, He Y, Peng Z, Hu G, Tao L, Meng J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:117216
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:117216
PRM1201 effectively inhibits colorectal cancer metastasis via shaping gut microbiota and short- chain fatty acids.
Jia R, Shao S, Zhang P, Yuan Y, Rong W, An Z, Lv S, Feng Y, Liu N, Feng Q, Wang Y, Li Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155795
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155795
Mechanism of Zhenwu Decoction modulating TLR4/NF-κB/HIF-1α loop through miR-451 to delay renal fibrosis in type 2 CRS.
Xu X, Wang Y, Song Q, Zheng H, Lv J, Fu Z, Mao X, Li Y, Wu H, Zhang B
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155632
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155632
Dihydromyricetin ameliorates diabetic renal fibrosis via regulating SphK1 to suppress the activation of NF-κB pathway.
Wen M, Sun X, Pan L, Jing S, Zhang X, Liang L, Xiao H, Liu P, Xu Z, Zhang Q, Huang H
European journal of pharmacology 2024 Sep 5;978:176799
European journal of pharmacology 2024 Sep 5;978:176799
Deletion of ASPP1 in myofibroblasts alleviates myocardial fibrosis by reducing p53 degradation.
Li S, Yang M, Zhao Y, Zhai Y, Sun C, Guo Y, Zhang X, Zhang L, Tian T, Yang Y, Pei Y, Li J, Li C, Xuan L, Li X, Zhao D, Yang H, Zhang Y, Yang B, Zhang Z, Pan Z, Lu Y
Nature communications 2024 Sep 28;15(1):8425
Nature communications 2024 Sep 28;15(1):8425
Combination of arsenic trioxide and apatinib synergistically inhibits small cell lung cancer by down-regulating VEGFR2/mTOR and Akt/c-Myc signaling pathway via GRB10.
Yu Y, Shang Y, Shi S, He Y, Shi W, Wang M, Wang Q, Xu D, Shi C, Chen H
Hereditas 2024 Sep 2;161(1):29
Hereditas 2024 Sep 2;161(1):29
IKKα-STAT3-S727 axis: a novel mechanism in DOX-induced cardiomyopathy.
Chen G, Yao Y, Liu Y, Zhang R, Wen C, Zhou Q, Xu Y, Wang W, Jiang H, Tao Z, Chen W, Qiu Z, Chen X
Cellular and molecular life sciences : CMLS 2024 Sep 17;81(1):406
Cellular and molecular life sciences : CMLS 2024 Sep 17;81(1):406
Novel Iridoid Derivatives Isolated from the Roots of Patrinia scabra with Potential Anti-Renal Fibrosis Activity In Vitro.
Li Z, Xu Y, Sun X, Fan Z, Zhou Z, Ren F, Li N, Di L
Molecules (Basel, Switzerland) 2024 Sep 17;29(18)
Molecules (Basel, Switzerland) 2024 Sep 17;29(18)
PMMA-induced biofilm promotes Schwann cells migration and proliferation mediated by EGF/Tnc/FN1 to improve sciatic nerve defect.
Wang J, Hu Y, Xue Y, Wang K, Mao D, Pan XY, Rui Y
Heliyon 2024 Sep 15;10(17):e37231
Heliyon 2024 Sep 15;10(17):e37231
Mechanosensitive Piezo1 channels promote neurogenic bladder fibrosis via regulating TGF-β1/smad and Hippo/YAP1 pathways.
Feng S, Yu Z, Yang Y, Xiong Q, Yan X, Bi Y
Experimental cell research 2024 Sep 1;442(1):114218
Experimental cell research 2024 Sep 1;442(1):114218
Attenuation of renal fibrosis in mice due to lack of bombesin receptor-activated protein homologue.
Peng Z, Wang H, Zheng J, Chen H, Wang J, Weber HC, Yuan L, Qin X, Xiang Y, Liu C, Ji M, Liu H, Qu X
Clinical and experimental pharmacology & physiology 2024 Oct;51(10):e13916
Clinical and experimental pharmacology & physiology 2024 Oct;51(10):e13916
CircNSD1 promotes cardiac fibrosis through targeting the miR-429-3p/SULF1/Wnt/β-catenin signaling pathway.
Ji DN, Jin SD, Jiang Y, Xu FY, Fan SW, Zhao YL, Liu XQ, Sun H, Cheng WZ, Zhang XY, Guan XX, Zhang BW, Du ZM, Wang Y, Wang N, Zhang R, Zhang MY, Xu CQ
Acta pharmacologica Sinica 2024 Oct;45(10):2092-2106
Acta pharmacologica Sinica 2024 Oct;45(10):2092-2106
Regulation of Fuzheng Huayu capsule on inhibiting the fibrosis-associated hepatocellular carcinogenesis.
Zhang WQ, Sun JX, Lan ST, Sun XM, Guo YJ, Wen BC, Chen J, Liu G
Journal of Asian natural products research 2024 Oct;26(10):1219-1238
Journal of Asian natural products research 2024 Oct;26(10):1219-1238
RELA-mediated upregulation of LINC03047 promotes ferroptosis in silica-induced pulmonary fibrosis via SLC39A14.
Zhang B, Wang E, Zhou S, Han R, Wu W, Sun G, Cao C, Wang R
Free radical biology & medicine 2024 Oct;223:250-262
Free radical biology & medicine 2024 Oct;223:250-262
Odontogenesis-Empowered Extracellular Vesicles Safeguard Donor-Recipient Stem Cell Interplay to Support Tooth Regeneration.
Huang X, Sui B, Liu A, Guo H, Zheng C, Liu P, Cai X, Fu F, Bai S, Jin F, Chen J, Wei C, Jin Y, Xuan K
Small (Weinheim an der Bergstrasse, Germany) 2024 Oct;20(42):e2400260
Small (Weinheim an der Bergstrasse, Germany) 2024 Oct;20(42):e2400260
Targeting SOCS2 alleviates myocardial fibrosis by reducing nuclear translocation of β-catenin.
Yuan M, Shi H, Wang B, Cai J, Yu W, Wang W, Qian Q, Wang Y, Zhou X, Liu J
Biochimica et biophysica acta. Molecular cell research 2024 Oct;1871(7):119804
Biochimica et biophysica acta. Molecular cell research 2024 Oct;1871(7):119804
GPR176 promotes fibroblast-to-myofibroblast transition in organ fibrosis progression.
Okamoto Y, Kitakaze K, Takenouchi Y, Matsui R, Koga D, Miyashima R, Ishimaru H, Tsuboi K
Biochimica et biophysica acta. Molecular cell research 2024 Oct;1871(7):119798
Biochimica et biophysica acta. Molecular cell research 2024 Oct;1871(7):119798
High-dose vitamin C attenuates radiation-induced pulmonary fibrosis by targeting S100A8 and S100A9.
Ma L, Jin Y, Aili A, Xu L, Wang X, Xiao L, Zhao W, Yin S, Liu B, Yuan X
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167358
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167358
ETS1 and RBPJ transcriptionally regulate METTL14 to suppress TGF-β1-induced epithelial-mesenchymal transition in human bronchial epithelial cells.
Chen JH, Li JJ, Yuan Y, Tian Q, Feng DD, Zhuang LL, Cao Q, Zhou GP, Jin R
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167349
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167349
Cinnamaldehyde activates AMPK/PGC-1α pathway via targeting GRK2 to ameliorate heart failure.
Xu Z, Li M, Lyu D, Xiao H, Li S, Li Z, Li M, Xiao J, Huang H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Oct;133:155894
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Oct;133:155894
Perinatal nicotine vaping exposure induces pro-myofibroblastic phenotype in rat bone marrow-derived mesenchymal stem cells.
Yu C, Liu J, Sakurai R, Wang Y, Afrose L, Gour A, Sharma A, Chandan G, Rehan VK
Reproductive toxicology (Elmsford, N.Y.) 2024 Oct;129:108673
Reproductive toxicology (Elmsford, N.Y.) 2024 Oct;129:108673
Hypoxia-induced DTL promotes the proliferation, metastasis, and sorafenib resistance of hepatocellular carcinoma through ubiquitin-mediated degradation of SLTM and subsequent Notch pathway activation.
Chen ZX, Mu MY, Yang G, Qi H, Fu XB, Wang GS, Jiang WW, Huang BJ, Gao F
Cell death & disease 2024 Oct 9;15(10):734
Cell death & disease 2024 Oct 9;15(10):734
Albendazole ameliorates aerobic glycolysis in myofibroblasts to reverse pulmonary fibrosis.
Zeng C, Yue H, Wang C, Ju X, Wang T, Fu X, Zhou Q, Zhang H, He L, Yu J, Wang Y
Journal of translational medicine 2024 Oct 7;22(1):910
Journal of translational medicine 2024 Oct 7;22(1):910
TRβ activation confers AT2-to-AT1 cell differentiation and anti-fibrosis during lung repair via KLF2 and CEBPA.
Pan X, Wang L, Yang J, Li Y, Xu M, Liang C, Liu L, Li Z, Xia C, Pang J, Wang M, Li M, Guo S, Yan P, Ding C, Rosas IO, Yu G
Nature communications 2024 Oct 7;15(1):8672
Nature communications 2024 Oct 7;15(1):8672
Baricitinib alleviates cardiac fibrosis and inflammation induced by chronic sympathetic activation.
Li W, Liu J, Jiao R, Liu Z, Zhang T, Chai D, Meng L, Yang Z, Liu Y, Gu X, Li X, Yang C
International immunopharmacology 2024 Oct 25;140:112894
International immunopharmacology 2024 Oct 25;140:112894
Mitochondrial MOF regulates energy metabolism in heart failure via ATP5B hyperacetylation.
Hu Y, Zheng Y, Liu C, You Y, Wu Y, Wang P, Wu Y, Ba H, Lu J, Yuan Y, Liu P, Mao Y
Cell reports 2024 Oct 22;43(10):114839
Cell reports 2024 Oct 22;43(10):114839
CCT6A alleviates pulmonary fibrosis by inhibiting HIF-1α-mediated lactate production.
Yan P, Yang K, Xu M, Zhu M, Duan Y, Li W, Liu L, Liang C, Li Z, Pan X, Wang L, Yu G
Journal of molecular cell biology 2024 Oct 21;16(5)
Journal of molecular cell biology 2024 Oct 21;16(5)
MiR-1307-5p enhances fibroblast transdifferentiation to exacerbate chronic obstructive pulmonary disease through regulating FBXL16/HIF1α axis.
Yao LP, Wang ZK, Jiang XQ, Jiang B, Chen SJ, Hua ZD, Gao DD, Zheng Q, Zhu SM, Qian MX, Zhang F, Xu LF, Chen CS, Lu F
Respiratory research 2024 Oct 17;25(1):376
Respiratory research 2024 Oct 17;25(1):376
Hydrogen-releasing magnesium hydrogel mitigates post laminectomy epidural fibrosis through inhibition of neutrophil extracellular traps.
Mei R, Sun J, Cao S, Shi M, Song Z, Hua F, Zhou G, Zhang M, Liu J
Acta biomaterialia 2024 Oct 15;188:420-431
Acta biomaterialia 2024 Oct 15;188:420-431
Asiaticoside improves diabetic nephropathy by reducing inflammation, oxidative stress, and fibrosis: An in vitro and in vivo study.
Zhuang LG, Zhang R, Jin GX, Pei XY, Wang Q, Ge XX
World journal of diabetes 2024 Oct 15;15(10):2111-2122
World journal of diabetes 2024 Oct 15;15(10):2111-2122
Galectin-3 inhibition reduces fibrotic scarring and promotes functional recovery after spinal cord injury in mice.
Shan F, Ye J, Xu X, Liang C, Zhao Y, Wang J, Ouyang F, Li J, Lv J, Wu Z, Yao F, Jing J, Zheng M
Cell & bioscience 2024 Oct 15;14(1):128
Cell & bioscience 2024 Oct 15;14(1):128
Peripheral dopamine suppression and elevated cystatin C in early diabetic nephropathy in spontaneously diabetic rats.
Horita S, Watanabe G, Misaka S, Taira S, Satoh M, Maejima Y, Shimomura K, Shimabukuro M, Kazama JJ, Shigetomi S
American journal of physiology. Renal physiology 2024 Oct 1;327(4):F581-F590
American journal of physiology. Renal physiology 2024 Oct 1;327(4):F581-F590
Cell Communications Between GCs and Macrophages Contribute to the Residence of Macrophage in Preovulatory Follicles.
Wu H, Zhang C, Zhu R, Meng Q, Wang F, Gao L, Zhao N, Li H, Li M
American journal of reproductive immunology (New York, N.Y. : 1989) 2024 Nov;92(5):e70009
American journal of reproductive immunology (New York, N.Y. : 1989) 2024 Nov;92(5):e70009
The LncRNA6524/miR-92a-2-5p/Dvl1/Wnt/β-catenin axis promotes renal fibrosis in the UUO mouse model.
Xie Y, Zhang G, Pan J, Qiu S, Zhang D
Archives of biochemistry and biophysics 2024 Nov;761:110175
Archives of biochemistry and biophysics 2024 Nov;761:110175
Gene Profiling of Circular RNAs in Keloid-prone Individuals and ceRNA Network Construction During Wound Healing.
Yang J, Zhu Z, Xu Y, Xu S, Zhang Y, Liu Z, Liu X, Shi J, Han B
Aesthetic plastic surgery 2024 Nov;48(21):4534-4545
Aesthetic plastic surgery 2024 Nov;48(21):4534-4545
Exosomal miR-552-3p isolated from BALF of patients with silicosis induces fibroblast activation.
Li M, Li Y, Liu Q, Jiang M, He Y, Liao X, Tao L, Meng J
Toxicology letters 2024 Nov;401:55-70
Toxicology letters 2024 Nov;401:55-70
Tenascin-C induces transdifferentiation of retinal pigment epithelial cells in proliferative vitreoretinopathy.
Zong T, Mu T, Tan C, Xie T, Zhuang M, Wang Y, Li Z, Yang Q, Wu M, Cai J, Wang X, Yao Y
Experimental eye research 2024 Nov;248:110097
Experimental eye research 2024 Nov;248:110097
Dietary sodium modulates mTORC1-dependent trained immunity in macrophages to accelerate CKD development.
Chen H, Song J, Zeng L, Zha J, Zhu J, Chen A, Liu Y, Dong Z, Chen G
Biochemical pharmacology 2024 Nov;229:116505
Biochemical pharmacology 2024 Nov;229:116505
LncRNA H19 accelerates renal fibrosis by negatively regulating the let-7b-5p/TGF-βR1/COL1A1 axis.
Li HY, Xu XY, Lv SH, Chen W, Wang Y, Fu Y, Yang JP
Cellular signalling 2024 Nov;123:111373
Cellular signalling 2024 Nov;123:111373
Three-Dimensional Semiconductor Network as Regulators of Energy Metabolism Drives Angiogenesis in Bone Regeneration.
Fan Y, Sun J, Fan W, Zhong X, Yin Z, Su B, Yao J, Hong X, Zhai J, Wang Z, Chen H, Guo F, Wen X, Ning C, Chen L, Yu P
ACS nano 2024 Nov 26;18(47):32602-32616
ACS nano 2024 Nov 26;18(47):32602-32616
DsbA-L activates TGF-β1/SMAD3 signaling and M2 macrophage polarization by stimulating AKT1 and NLRP3 to promote pulmonary fibrosis.
Wang J, Xia Z, Qing B, Chen Y, Gu L, Chen H, Ge Z, Yuan Y
Molecular medicine (Cambridge, Mass.) 2024 Nov 23;30(1):228
Molecular medicine (Cambridge, Mass.) 2024 Nov 23;30(1):228
Ficolin-1 ameliorates pulmonary fibrosis via directly binding to TGF-β1.
Gao P, Lu Y, Tang K, Wang W, Wang T, Zhu Y, Zhao J, Mao Y
Journal of translational medicine 2024 Nov 21;22(1):1051
Journal of translational medicine 2024 Nov 21;22(1):1051
The in vivo effects of knockdown of long non-coding RNA XIST on fibroid growth and gene expression.
Chuang TD, Ton N, Rysling S, Khorram O
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Nov 15;38(21):e70140
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Nov 15;38(21):e70140
P2Y12-targeted modulation of microglial phenotypes: A novel therapeutic strategy for enhanced axonal regeneration post-spinal cord injury.
Zhang K, Wen R, Ma W, Ji H, He X, Yang Z, Liu D, Li X
Life sciences 2024 Nov 15;357:123057
Life sciences 2024 Nov 15;357:123057
CD8(+) tissue-resident memory T cells are essential in bleomycin-induced pulmonary fibrosis.
Feng X, Yu F, He XL, Cheng PP, Niu Q, Zhao LQ, Li Q, Cui XL, Jia ZH, Ye SY, Liang LM, Song LJ, Xiong L, Xiang F, Wang X, Ma WL, Ye H
American journal of physiology. Cell physiology 2024 Nov 1;327(5):C1178-C1191
American journal of physiology. Cell physiology 2024 Nov 1;327(5):C1178-C1191
Gaudichaudione H ameliorates liver fibrosis and inflammation by targeting NRF2 signaling pathway.
Shi M, Guo Y, Xu J, Yan L, Li X, Liu R, Feng Y, Zhang Y, Zhao Y, Zhang C, Du K, Li M, Zhang Y, Zhang J, Li Z, Ren D, Liu P
Free radical biology & medicine 2024 Nov 1;224:770-784
Free radical biology & medicine 2024 Nov 1;224:770-784
Exposure to micron-grade silica particles triggers pulmonary fibrosis through cell-to-cell delivery of exosomal miR-107.
Xia J, Wang D, Guo W, Pei Y, Zhang L, Bao L, Li Y, Qu Y, Zhao Y, Hao C, Yao W
International journal of biological macromolecules 2024 May;266(Pt 1):131058
International journal of biological macromolecules 2024 May;266(Pt 1):131058
TGF-β1 inhibitor P144 protects against benign restenosis after esophageal stenting through TGF-β1/Smads signaling pathway inhibition.
Wu JZ, Zhou C, Liu S, Zhang JX, Yang W, Shi HB, Zhou WZ
Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology 2024 May;25(2):214-222
Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology 2024 May;25(2):214-222
Kefir peptides mitigate bleomycin-induced pulmonary fibrosis in mice through modulating oxidative stress, inflammation and gut microbiota.
Lan YW, Chen YC, Yen CC, Chen HL, Tung MC, Fan HC, Chen CM
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116431
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116431
Pirfenidone alleviates fibrosis by acting on tumour-stroma interplay in pancreatic cancer.
Lei Y, Xu J, Xiao M, Wu D, Xu H, Yang J, Mao X, Pan H, Yu X, Shi S
British journal of cancer 2024 May;130(9):1505-1516
British journal of cancer 2024 May;130(9):1505-1516
SOAT1 regulates cholesterol metabolism to induce EMT in hepatocellular carcinoma.
Fu R, Xue W, Liang J, Li X, Zheng J, Wang L, Zhang M, Meng J
Cell death & disease 2024 May 9;15(5):325
Cell death & disease 2024 May 9;15(5):325
Effects of Nanoparticle-Mediated Dihydromyricetin to Diabetic Wounds: An In Vivo Study.
Wang ZN, Ma JC, Xi MF, Yin D, Jiang LF, Qi J
Journal of burn care & research : official publication of the American Burn Association 2024 May 6;45(3):644-654
Journal of burn care & research : official publication of the American Burn Association 2024 May 6;45(3):644-654
Describing the Cellular Impact of IQOS™ Smoke Extract and Vibration on Human Vocal Fold Fibroblasts.
Grossmann T, Kirsch A, Gerstenberger C, Steffan B, Gugatschka M
Journal of voice : official journal of the Voice Foundation 2024 May 4;
Journal of voice : official journal of the Voice Foundation 2024 May 4;
Human amnion mesenchymal stem cells promote endometrial repair via paracrine, preferentially than transdifferentiation.
Huang X, Yang X, Huang J, Wei L, Mao Y, Li C, Zhang Y, Chen Q, Wu S, Xie L, Sun C, Zhang W, Wang J
Cell communication and signaling : CCS 2024 May 31;22(1):301
Cell communication and signaling : CCS 2024 May 31;22(1):301
Lactate facilitated mitochondrial fission-derived ROS to promote pulmonary fibrosis via ERK/DRP-1 signaling.
Sun Z, Ji Z, Meng H, He W, Li B, Pan X, Zhou Y, Yu G
Journal of translational medicine 2024 May 21;22(1):479
Journal of translational medicine 2024 May 21;22(1):479
The role of FERMT2 in the tumor microenvironment and immunotherapy in pan-cancer using comprehensive single-cell and bulk sequencing.
Wu GH, He C, Che G, Zhou Z, Chen BY, Wu HM, Chen JF, Zhu WP, Yang Y, Zhou Z, Teng LS, Wang HY
Heliyon 2024 May 15;10(9):e30505
Heliyon 2024 May 15;10(9):e30505
Generation and application of immortalized sheep fetal fibroblast cell line.
Du G, Zhang C, Cao X, Li L, Zhang Y, Shang Y, Wu J
BMC veterinary research 2024 May 14;20(1):198
BMC veterinary research 2024 May 14;20(1):198
The Rejuvenation and Functional Restoration of Aged Adipose Stem Cells by DUXAP10 Knockdown via the Regulation of the miR-214-3p/RASSF5 Axis.
Ren S, Li C, Xiong H, Wu Q, Wu X, Xiong Z, Dong L, Shu B, Wei W, Ma C, Li X, Chen J
Stem cells translational medicine 2024 May 14;13(5):462-476
Stem cells translational medicine 2024 May 14;13(5):462-476
Ribosomal Dysregulation in Metastatic Laryngeal Squamous Cell Carcinoma: Proteomic Insights and CX-5461's Therapeutic Promise.
Gao M, Liu T, Hu K, Chen S, Wang S, Gan D, Li Z, Lin X
Toxics 2024 May 13;12(5)
Toxics 2024 May 13;12(5)
Targeting RORγ inhibits the growth and metastasis of hepatocellular carcinoma.
Liu Q, Wang J, Sun H, Zhang Z, Wang H, Ma S, Zhang C, Wang Q, Cai G, Zheng J, Nie Y, Liu P, Wang J
Molecular therapy : the journal of the American Society of Gene Therapy 2024 Mar 6;32(3):749-765
Molecular therapy : the journal of the American Society of Gene Therapy 2024 Mar 6;32(3):749-765
Remimazolam attenuates inflammation and kidney fibrosis following folic acid injury.
Song J, Yu W, Chen S, Huang J, Zhou C, Liang H
European journal of pharmacology 2024 Mar 5;966:176342
European journal of pharmacology 2024 Mar 5;966:176342
Astaxanthin attenuates cigarette smoke-induced small airway remodeling via the AKT1 signaling pathway.
Ding H, Yan L, Wang Y, Lu Y, Deng M, Wang Y, Wang Q, Zhou X
Respiratory research 2024 Mar 30;25(1):148
Respiratory research 2024 Mar 30;25(1):148
Wnt5a/β-catenin-mediated epithelial-mesenchymal transition: a key driver of subretinal fibrosis in neovascular age-related macular degeneration.
Liu D, Du J, Xie H, Tian H, Lu L, Zhang C, Xu GT, Zhang J
Journal of neuroinflammation 2024 Mar 26;21(1):75
Journal of neuroinflammation 2024 Mar 26;21(1):75
Nuciferine reduces vascular leakage and improves cardiac function in acute myocardial infarction by regulating the PI3K/AKT pathway.
Xie W, Chen S, Wang W, Qin X, Kong C, Wang D
Scientific reports 2024 Mar 26;14(1):7086
Scientific reports 2024 Mar 26;14(1):7086
PDE12 disrupts mitochondrial oxidative phosphorylation and mediates mitochondrial dysfunction to induce oral mucosal epithelial barrier damage in oral submucous fibrosis.
Wei Q, Chen L, Luo W, Chen C, Shi Y, Xie J, Xie X, Luo HB
European journal of pharmacology 2024 Mar 15;967:176353
European journal of pharmacology 2024 Mar 15;967:176353
Fibroblast-Specific Depletion of Human Antigen R Alleviates Myocardial Fibrosis Induced by Cardiac Stress.
Patil M, Singh S, Dubey PK, Tousif S, Umbarkar P, Zhang Q, Lal H, Sewell-Loftin MK, Umeshappa CS, Ghebre YT, Pogwizd S, Zhang J, Krishnamurthy P
JACC. Basic to translational science 2024 Jun;9(6):754-770
JACC. Basic to translational science 2024 Jun;9(6):754-770
Preventive effects of Ramelteon on bleomycin-induced pulmonary fibrosis in mice.
Zhang L, Cheng T, Chen W, Zhong C, Li M, Xie Y, Deng Q, Wang H, Yang Z, Ju J, Liang H
Naunyn-Schmiedeberg's archives of pharmacology 2024 Jun;397(6):4153-4163
Naunyn-Schmiedeberg's archives of pharmacology 2024 Jun;397(6):4153-4163
Kokusaginine attenuates renal fibrosis by inhibiting the PI3K/AKT signaling pathway.
Wang Y, Han Y, Shang K, Xiao J, Tao L, Peng Z, Liu S, Jiang Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jun;175:116695
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jun;175:116695
Synergistic effects of photodynamic therapy and chemotherapy: Activating the intrinsic/extrinsic apoptotic pathway of anoikis for triple-negative breast cancer treatment.
Zhang T, Wang X, Wang D, Lei M, Hu Y, Chen Z, Li Y, Luo Y, Zhang L, Zhu Y
Biomaterials advances 2024 Jun;160:213859
Biomaterials advances 2024 Jun;160:213859
Modified mRNA-Mediated CCN5 Gene Transfer Ameliorates Cardiac Dysfunction and Fibrosis without Adverse Structural Remodeling.
Song MH, Yoo J, Kwon DA, Chepurko E, Cho S, Fargnoli A, Hajjar RJ, Park WJ, Zangi L, Jeong D
International journal of molecular sciences 2024 Jun 6;25(11)
International journal of molecular sciences 2024 Jun 6;25(11)
Platelet membrane biomimetic nanoparticle-targeted delivery of TGF-β1 siRNA attenuates renal inflammation and fibrosis.
Fei S, Ma Y, Zhou B, Chen X, Zhang Y, Yue K, Li Q, Gui Y, Xiang T, Liu J, Yang B, Wang L, Huang X
International journal of pharmaceutics 2024 Jun 25;659:124261
International journal of pharmaceutics 2024 Jun 25;659:124261
The Development of a 3D PET Fibrous Scaffold Modified with an Umbilical Cord dECM for Liver Tissue Engineering.
Li Y, Zhang Y, Zhong K, Liao S, Zhang G
Polymers 2024 Jun 25;16(13)
Polymers 2024 Jun 25;16(13)
In Vivo Effects of Bay 11-7082 on Fibroid Growth and Gene Expression: A Preclinical Study.
Chuang TD, Ton N, Rysling S, Khorram O
Cells 2024 Jun 24;13(13)
Cells 2024 Jun 24;13(13)
Fibronectin-Targeting Dual-Modal MR/NIRF Imaging Contrast Agents for Diagnosis of Gastric Cancer and Peritoneal Metastasis.
Yang N, Huang Y, Wang X, Wang D, Yao D, Ren G
Bioconjugate chemistry 2024 Jun 19;35(6):843-854
Bioconjugate chemistry 2024 Jun 19;35(6):843-854
Targeting the long non-coding RNA MIAT for the treatment of fibroids in an animal model.
Chuang TD, Ton N, Manrique N, Rysling S, Khorram O
Clinical science (London, England : 1979) 2024 Jun 19;138(12):699-709
Clinical science (London, England : 1979) 2024 Jun 19;138(12):699-709
Bone transport induces the release of factors with multi-tissue regenerative potential for diabetic wound healing in rats and patients.
Xie J, Liu X, Wu B, Chen B, Song Q, Guan Y, Gong Y, Yang C, Lin J, Huang M, Tan X, Lai R, Lin X, Zhang S, Xie X, Chen X, Zhang C, Yang M, Nong H, Zhao X, Xia L, Zhou W, Xiao G, Jiang Q, Zou W, Chen D, Lu D, Liu J, Bai X
Cell reports. Medicine 2024 Jun 18;5(6):101588
Cell reports. Medicine 2024 Jun 18;5(6):101588
Hyperbaric oxygen enhances tumor penetration and accumulation of engineered bacteria for synergistic photothermal immunotherapy.
Xu KF, Wu SY, Wang Z, Guo Y, Zhu YX, Li C, Shan BH, Zhang X, Liu X, Wu FG
Nature communications 2024 Jun 17;15(1):5147
Nature communications 2024 Jun 17;15(1):5147
Xinbao Pill ameliorates heart failure via regulating the SGLT1/AMPK/PPARα axis to improve myocardial fatty acid energy metabolism.
Pan L, Xu Z, Wen M, Li M, Lyu D, Xiao H, Li Z, Xiao J, Cheng Y, Huang H
Chinese medicine 2024 Jun 11;19(1):82
Chinese medicine 2024 Jun 11;19(1):82
YAP1 inhibits the senescence of alveolar epithelial cells by targeting Prdx3 to alleviate pulmonary fibrosis.
Su W, Guo Y, Wang Q, Ma L, Zhang Q, Zhang Y, Geng Y, Jin T, Guo J, Yang R, Niu Z, Ren L, Wang Y, Ning Z, Li W, He W, Sun J, Li T, Li Z, Shan H, Liang H
Experimental & molecular medicine 2024 Jul;56(7):1643-1654
Experimental & molecular medicine 2024 Jul;56(7):1643-1654
Parkin deficiency promotes liver cancer metastasis by TMEFF1 transcription activation via TGF-β/Smad2/3 pathway.
Su Q, Wang JJ, Ren JY, Wu Q, Chen K, Tu KH, Zhang Y, Leong SW, Sarwar A, Han X, Zhang M, Dai WF, Zhang YM
Acta pharmacologica Sinica 2024 Jul;45(7):1520-1529
Acta pharmacologica Sinica 2024 Jul;45(7):1520-1529
Silibinin attenuates TGF-β2-induced fibrogenic changes in human trabecular meshwork cells by targeting JAK2/STAT3 and PI3K/AKT signaling pathways.
Wu X, Liang J, Liu J, Huang Y, Zhang L, Liu X, Guo J, Zhang M, Chen Y, Wang J
Experimental eye research 2024 Jul;244:109939
Experimental eye research 2024 Jul;244:109939
Picroside II promotes HSC apoptosis and inhibits the cholestatic liver fibrosis in Mdr2(-/-) mice by polarizing M1 macrophages and balancing immune responses.
Jia K, Ma Z, Zhang Y, Xie K, Li J, Wu J, Qu J, Li F, Li X
Chinese journal of natural medicines 2024 Jul;22(7):582-598
Chinese journal of natural medicines 2024 Jul;22(7):582-598
Long Non-coding RNA ZFAS1 Regulates Fibrosis and Scortosis in the Cell Model of Diabetic Nephropathy Through miR-525-5p/SGK1 Axis.
Zhuang L, Jin G, Wang Q, Ge X, Pei X
Applied biochemistry and biotechnology 2024 Jul;196(7):3731-3746
Applied biochemistry and biotechnology 2024 Jul;196(7):3731-3746
The histone deacetylase inhibitor MS-275 enhances the matrix mineralization of dental pulp stem cells by inducing fibronectin expression.
Suzuki S, Sasaki K, Fahreza RR, Nemoto E, Yamada S
Journal of dental sciences 2024 Jul;19(3):1680-1690
Journal of dental sciences 2024 Jul;19(3):1680-1690
Hydrogen Therapy Reverses Cancer-Associated Fibroblasts Phenotypes and Remodels Stromal Microenvironment to Stimulate Systematic Anti-Tumor Immunity.
Meng X, Liu Z, Deng L, Yang Y, Zhu Y, Sun X, Hao Y, He Y, Fu J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jul;11(28):e2401269
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jul;11(28):e2401269
DKK1 loss promotes endometrial fibrosis via autophagy and exosome-mediated macrophage-to-myofibroblast transition.
Zhang Z, Hu J
Journal of translational medicine 2024 Jul 3;22(1):617
Journal of translational medicine 2024 Jul 3;22(1):617
Icariside II modulates pulmonary fibrosis via PI3K/Akt/β-catenin pathway inhibition of M2 macrophage program.
Deng L, Ouyang B, Tang W, Wang N, Yang F, Shi H, Zhang Z, Yu H, Chen M, Wei Y, Dong J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155687
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155687
Endothelial progenitor cells control remodeling of uterine spiral arteries for the establishment of utero-placental circulation.
Tan B, Lin L, Yuan Y, Long Y, Kang Y, Huang B, Huang LF, Li JH, Tong C, Qi HB
Developmental cell 2024 Jul 22;59(14):1842-1859.e12
Developmental cell 2024 Jul 22;59(14):1842-1859.e12
Epithelial CEBPD activates fibronectin and enhances macrophage adhesion in renal ischemia-reperfusion injury.
Chang SS, Cheng CC, Chen YR, Chen FW, Cheng YM, Wang JM
Cell death discovery 2024 Jul 18;10(1):328
Cell death discovery 2024 Jul 18;10(1):328
Inhalation of hydrogen gas protects against mitomycin-induced pulmonary veno-occlusive disease.
Zhang C, Xing Y, Wu X, Jiang Q, Luo X, He W, Liu S, Lu W, Wang J
Respiratory research 2024 Jul 16;25(1):281
Respiratory research 2024 Jul 16;25(1):281
Procyanidin C1 inhibits bleomycin-induced pulmonary fibrosis in mice by selective clearance of senescent myofibroblasts.
Shao M, Qiu Y, Shen M, Liu W, Feng D, Luo Z, Zhou Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jul 15;38(13):e23749
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jul 15;38(13):e23749
CD24 promotes metastasis and chemoresistance by directly targeting Arf6-ERK pathway in esophageal squamous cell carcinoma.
Hong P, Xu T, Xu J, Chen W, Hu H, Chen J, Li L, Zheng C, Li B, Liu J, Dai W, Li E, Zhang F, Xu W
Cancer letters 2024 Jul 10;594:216994
Cancer letters 2024 Jul 10;594:216994
Cell fusion upregulates PD-L1 expression for evasion from immunosurveillance.
Tajima Y, Shibasaki F, Masai H
Cancer gene therapy 2024 Jan;31(1):158-173
Cancer gene therapy 2024 Jan;31(1):158-173
Chitosan-based oral nanoparticles as an efficient platform for kidney-targeted drug delivery in the treatment of renal fibrosis.
Zhang Q, Li Y, Wang S, Gu D, Zhang C, Xu S, Fang X, Li C, Wu H, Xiong W
International journal of biological macromolecules 2024 Jan;256(Pt 1):128315
International journal of biological macromolecules 2024 Jan;256(Pt 1):128315
Lactate accumulation induced by Akt2-PDK1 signaling promotes pulmonary fibrosis.
Sun Z, Ji Z, He W, Duan R, Qu J, Yu G
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan 31;38(2):e23426
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan 31;38(2):e23426
In silico prediction and experimental validation to reveal the protective mechanism of Puerarin against excessive extracellular matrix accumulation through inhibiting ferroptosis in diabetic nephropathy.
Hou B, Ma P, Yang X, Zhao X, Zhang L, Zhao Y, He P, Zhang L, Du G, Qiang G
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117281
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117281
A cardiotoxicity-eliminated ACE2 variant as a pan-inhibitor against coronavirus cell invasion.
Feng H, Yang L, Yang H, Cheng D, Li M, Song E, Xu T
Molecular therapy : the journal of the American Society of Gene Therapy 2024 Jan 3;32(1):218-226
Molecular therapy : the journal of the American Society of Gene Therapy 2024 Jan 3;32(1):218-226
Inhibition of heme oxygenase 1 alleviates thoracic aortic aneurysm via restoration of extracellular matrix.
Song W, Shen K, Fu G, Qin L, Bagaber G, Chen J, Wei L
Biochemical and biophysical research communications 2024 Jan 29;694:149405
Biochemical and biophysical research communications 2024 Jan 29;694:149405
Rehmannia glutinosa Libosch and Cornus officinalis Sieb herb couple ameliorates renal interstitial fibrosis in CKD rats by inhibiting the TGF-β1/MAPK signaling pathway.
Zhu JH, Wang L, Ma ZX, Duan JA, Tao JH
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117039
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117039
hPMSCs Regulate the Level of TNF-α and IL-10 in Th1 Cells and Improve Hepatic Injury in a GVHD Mouse Model via CD73/ADO/Fyn/Nrf2 Axis.
Zhang H, Han K, Li H, Zhang J, Zhao Y, Wu Y, Wang B, Ma J, Luan X
Inflammation 2024 Feb;47(1):244-263
Inflammation 2024 Feb;47(1):244-263
Microplastics cause hepatotoxicity in diabetic mice by disrupting glucolipid metabolism via PP2A/AMPK/HNF4A and promoting fibrosis via the Wnt/β-catenin pathway.
Li X, Feng L, Kuang Q, Wang X, Yang J, Niu X, Gao L, Huang L, Luo P, Li L
Environmental toxicology 2024 Feb;39(2):1018-1030
Environmental toxicology 2024 Feb;39(2):1018-1030
Alleviative Effect of Lactoferrin Interventions Against the Hepatotoxicity Induced by Titanium Dioxide Nanoparticles.
Zhang W, Sun J, Liu F, Li S, Wang X, Su L, Liu G
Biological trace element research 2024 Feb;202(2):624-642
Biological trace element research 2024 Feb;202(2):624-642
Targeting ROCK1 in diabetic kidney disease: Unraveling mesangial fibrosis mechanisms and introducing myricetin as a novel antagonist.
Yuan N, Diao J, Dong J, Yan Y, Chen Y, Yan S, Liu C, He Z, He J, Zhang C, Wang H, Wang M, He F, Xiao W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Feb;171:116208
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Feb;171:116208
Discovery of PRDM16-Mediated TRPA1 Induction as the Mechanism for Low Tubulo-Interstitial Fibrosis in Diabetic Kidney Disease.
Xu F, Jiang H, Li X, Pan J, Li H, Wang L, Zhang P, Chen J, Qiu S, Xie Y, Li Y, Zhang D, Dong Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Feb;11(7):e2306704
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Feb;11(7):e2306704
Endothelial Robo4 suppresses endothelial-to-mesenchymal transition induced by irradiation and improves hematopoietic reconstitution.
Adzraku SY, Cao C, Zhou Q, Yuan K, Hao X, Li Y, Yuan S, Huang Y, Xu K, Qiao J, Ju W, Zeng L
Cell death & disease 2024 Feb 21;15(2):159
Cell death & disease 2024 Feb 21;15(2):159
Forensic significance of intracardiac expressions of Nrf2 in acute myocardial ischemia.
Hiyamizu S, Ishida Y, Yasuda H, Kuninaka Y, Nosaka M, Ishigami A, Shimada E, Kimura A, Yamamoto H, Osako M, Zhang W, Goto U, Kamata T, Kondo T
Scientific reports 2024 Feb 19;14(1):4046
Scientific reports 2024 Feb 19;14(1):4046
Endothelium-specific deletion of p62 causes organ fibrosis and cardiac dysfunction.
Feng J, Li Y, Zhang Y, Sun S, Sun J, Xu Q, Ji X, Liu Y, Wan Q
Journal of translational medicine 2024 Feb 16;22(1):161
Journal of translational medicine 2024 Feb 16;22(1):161
Up-regulation of long non-coding RNA H19 ameliorates renal tubulointerstitial fibrosis by reducing lipid deposition and inflammatory response through regulation of the microRNA-130a-3p/long-chain acyl-CoA synthetase 1 axis.
Jiang Y, Ma F, Wang J, Chen X, Xue L, Chen X, Hu J
Non-coding RNA research 2024 Dec;9(4):1120-1132
Non-coding RNA research 2024 Dec;9(4):1120-1132
METTL3 silencing inhibits ferroptosis to suppress ovarian fibrosis in PCOS by upregulating m6A modification of GPX4.
Shen C, Jiang Y, Lin J, Guo Q, Fang D
Journal of molecular histology 2024 Dec;55(6):1163-1175
Journal of molecular histology 2024 Dec;55(6):1163-1175
Chronic exposure to polystyrene microplastics induces renal fibrosis via ferroptosis.
Hong R, Shi Y, Fan Z, Gao Y, Chen H, Pan C
Toxicology 2024 Dec;509:153996
Toxicology 2024 Dec;509:153996
MiR-454-3p regulates high glucose-induced mesothelial-mesenchymal transition and glycolysis in peritoneal mesothelial cells by targeting STAT3.
Li N, Fu J, Wang Q, Rao Q, Yao L, Shao X, Zhang P
Renal failure 2024 Dec;46(2):2394635
Renal failure 2024 Dec;46(2):2394635
Oridonin ameliorates renal fibrosis in diabetic nephropathy by inhibiting the Wnt/β-catenin signaling pathway.
Li J, Shu L, Jiang Q, Feng B, Bi Z, Zhu G, Zhang Y, Li X, Wu J
Renal failure 2024 Dec;46(1):2347462
Renal failure 2024 Dec;46(1):2347462
Iguratimod prevents renal fibrosis in unilateral ureteral obstruction model mice by suppressing M2 macrophage infiltration and macrophage-myofibroblast transition.
Zhou Y, Li Z, Yu S, Wang X, Xie T, Zhang W
Renal failure 2024 Dec;46(1):2327498
Renal failure 2024 Dec;46(1):2327498
Mesenchymal stem cells may alleviate angiotensin II-induced myocardial fibrosis and hypertrophy by upregulating SFRS3 expression.
Gu L, Wan X, Liu Y, Gong Z, Huang R, Shi Y, Liu H
Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology 2024 Dec;43(12):645-656
Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology 2024 Dec;43(12):645-656
Aristolochic acid I promotes renal tubulointerstitial fibrosis by up-regulating expression of indoleamine 2,3-dioxygenase-1 (IDO1).
Chen L, Cheng S, Ying J, Zhang Q, Wang C, Wu H, Wang Y, Zhang H, Wang J, Ye J, Zhang L
Toxicology letters 2024 Dec;402:44-55
Toxicology letters 2024 Dec;402:44-55
Pachymic acid ameliorates bleomycin-induced pulmonary fibrosis through inhibiting endoplasmic reticulum stress in rats.
Li L, Jin RJ, Ji L
Environmental toxicology 2024 Dec;39(12):5382-5390
Environmental toxicology 2024 Dec;39(12):5382-5390
Cell Sheets Formation Enhances Therapeutic Effects of Human Umbilical Cord Mesenchymal Stem Cells on Spinal Cord Injury.
Zhao Y, Wu Z, Zhou Y, Chen C, Lu Y, Wang H, Xu T, Yang C, Chen X
CNS neuroscience & therapeutics 2024 Dec;30(12):e70163
CNS neuroscience & therapeutics 2024 Dec;30(12):e70163
Methane saline suppresses ferroptosis via the Nrf2/HO-1 signaling pathway to ameliorate intestinal ischemia-reperfusion injury.
Fan Q, Chang H, Tian L, Zheng B, Liu R, Li Z
Redox report : communications in free radical research 2024 Dec;29(1):2373657
Redox report : communications in free radical research 2024 Dec;29(1):2373657
MSCs-derived ECM functionalized hydrogel regulates macrophage reprogramming for osteoarthritis treatment by improving mitochondrial function and energy metabolism.
Chen Z, Pang Q, Zhan J, Liu J, Zhao W, Dong L, Huang W
Materials today. Bio 2024 Dec;29:101340
Materials today. Bio 2024 Dec;29:101340
Tissue-engineered collagen matrix loaded with rat adipose-derived stem cells/human amniotic mesenchymal stem cells for rotator cuff tendon-bone repair.
Shi J, Yao H, Chong H, Hu X, Yang J, Dai X, Liu D, Wu Z, Dang M, Fei W, Wang DA
International journal of biological macromolecules 2024 Dec;282(Pt 4):137144
International journal of biological macromolecules 2024 Dec;282(Pt 4):137144
Dihydrolipoamide S-acetyltransferase activation alleviates diabetic kidney disease via AMPK-autophagy axis and mitochondrial protection.
Zhou P, Wang N, Lu S, Xiong J, Zhang Y, Jiang Q, Qian Q, Zhou Q, Liu J, Chen S
Translational research : the journal of laboratory and clinical medicine 2024 Dec;274:81-100
Translational research : the journal of laboratory and clinical medicine 2024 Dec;274:81-100
Calpain-1 Up-Regulation Promotes Bleomycin-Induced Pulmonary Fibrosis by Activating Ferroptosis.
Wei S, Liu Y, Ran C, Li Y, Tang B, Lu M, Wang H
The American journal of pathology 2024 Dec;194(12):2272-2289
The American journal of pathology 2024 Dec;194(12):2272-2289
Suyin Detoxification Granule alleviates trimethylamine N-oxide-induced tubular ferroptosis and renal fibrosis to prevent chronic kidney disease progression.
Ge H, Wei Y, Zhang W, Yong C, Chen Y, Zhou E
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156195
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156195
Cardioprotective effects of polydatin against myocardial injury in HFD/stz and high glucose-induced diabetes via a Caveolin 1-dependent mechanism.
Gong W, Zhang N, Sun X, Zhang Y, Wang Y, Lv D, Luo H, Liu Y, Chen Z, Lei Q, Zhao G, Bai L, Jiao Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156055
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156055
Quercetin prevents the USP22-Snail1 signaling pathway to ameliorate diabetic tubulointerstitial fibrosis.
Zhao X, Wang S, He X, Wei W, Huang K
Food & function 2024 Dec 9;15(24):11990-12006
Food & function 2024 Dec 9;15(24):11990-12006
The role of the PI3K/AKT/mTOR pathway in mediating PD-L1 upregulation during fibroblast transdifferentiation.
Zhao Y, Qi Y, Xia J, Duan M, Hao C, Yao W
International immunopharmacology 2024 Dec 5;142(Pt B):113186
International immunopharmacology 2024 Dec 5;142(Pt B):113186
Clostridium difficile-derived membrane vesicles promote fetal growth restriction via inhibiting trophoblast motility through PPARγ/RXRα/ANGPTL4 axis.
Zha Z, Jia C, Zhou R, Yin Q, Hu Y, Huang Z, Peng L, Zhang Y, Qiu X, Chen Y, Zhong Y, Wang Y, Pang M, Lu S, Sheng C, Huang L
NPJ biofilms and microbiomes 2024 Dec 31;10(1):158
NPJ biofilms and microbiomes 2024 Dec 31;10(1):158
Dual rectification of metabolism abnormality in pancreatic cancer by a programmed nanomedicine.
Wu B, Wang Z, Liu J, Li N, Wang X, Bai H, Wang C, Shi J, Zhang S, Song J, Li Y, Nie G
Nature communications 2024 Dec 3;15(1):10526
Nature communications 2024 Dec 3;15(1):10526
Ancestry-linked stromal variations impact breast epithelial cell invasion.
Schmidtmann M, Elliott V, Clancy J, Nakshatri H, D'Souza-Schorey C
bioRxiv : the preprint server for biology 2024 Dec 26;
bioRxiv : the preprint server for biology 2024 Dec 26;
METTL14 downregulates GLUT9 through m6A methylation and attenuates hyperuricemia-induced fibrosis in mouse renal tubular epithelial cells.
Yang J, Jiang T, Lu X, Li X, Zhou X, Guo X, Ma C, Xie X, Li D, Yu S, An J, Zhao B, Li H
International immunopharmacology 2024 Dec 25;143(Pt 1):113308
International immunopharmacology 2024 Dec 25;143(Pt 1):113308
Baicalin improves isoproterenol-induced cardiac remodeling by regulating the Nrf2-dependent signaling pathway.
Qian K, Song L, Guo JM, Fu D, Shi J, Ma Y, Ge ZJ, Li L, Zhang SQ
BMC cardiovascular disorders 2024 Dec 20;24(1):733
BMC cardiovascular disorders 2024 Dec 20;24(1):733
GS-4997 halts the progression of tubulointerstitial injury in lupus nephritis.
Xiao Z, Li G, Fu S, Chen Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Dec 13;38(24):e70253
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Dec 13;38(24):e70253
PAI-1 promotes human endometrial stromal decidualization via inhibiting VEGFR2/PI3K/AKT signaling pathway mediated F-actin reorganization.
Zhao H, Liu J, Yin S, Bao H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Dec 13;38(24):e70233
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Dec 13;38(24):e70233
Ameliorating lung fibrosis and pulmonary function in diabetic mice: Therapeutic potential of mesenchymal stem cell.
Aisanjiang M, Dai W, Wu L, Yuan Y, Liu S, Liao G, Li L, Tong X, Zhang H, Chen Y, Liu J, Cheng J, Wang C, Lu Y
Biochemical and biophysical research communications 2024 Dec 10;737:150495
Biochemical and biophysical research communications 2024 Dec 10;737:150495
Serum deprivation protein response intervenes in the proliferation, motility, and extracellular matrix production in keloid fibroblasts by blocking the amplification of TGF-β1/SMAD signal cascade via ERK1/2.
Li P, Han M, Wang L, Gao C
Toxicology and applied pharmacology 2024 Aug;489:117012
Toxicology and applied pharmacology 2024 Aug;489:117012
Macromolecular Crowding Enhances Matrix Protein Deposition in Tissue-Engineered Vascular Grafts.
Liu Q, Liu J, Sun XH, Xu JY, Xiao C, Jiang HJ, Wu YD, Lin ZY
Tissue engineering. Part A 2024 Aug;30(15-16):473-484
Tissue engineering. Part A 2024 Aug;30(15-16):473-484
Aging-Associated Metabolite Methylmalonic Acid Increases Susceptibility to Pulmonary Fibrosis.
Xu K, Ding L, Li W, Wang Y, Ma S, Lian H, Pan X, Wan R, Zhao W, Yang J, Rosas I, Wang L, Yu G
The American journal of pathology 2024 Aug;194(8):1478-1493
The American journal of pathology 2024 Aug;194(8):1478-1493
Aldehyde Dehydrogenase 2 Deficiency Aggravates Lung Fibrosis through Mitochondrial Dysfunction and Aging in Fibroblasts.
Wei Y, Gao S, Li C, Huang X, Xie B, Geng J, Dai H, Wang C
The American journal of pathology 2024 Aug;194(8):1458-1477
The American journal of pathology 2024 Aug;194(8):1458-1477
Lipoamide Attenuates Hypertensive Myocardial Hypertrophy Through PI3K/Akt-Mediated Nrf2 Signaling Pathway.
Cao H, Zhao L, Yuan Y, Liao C, Zeng W, Li A, Huang Q, Zhao Y, Fan Y, Jiang L, Song D, Li S, Zhang B
Journal of cardiovascular translational research 2024 Aug;17(4):910-922
Journal of cardiovascular translational research 2024 Aug;17(4):910-922
STC2 suppresses triple-negative breast cancer migration and invasion by inhibition on EMT and promotion on cell apoptosis.
Lei R, Yao C, Huang R, Wu W, Ou L, Yang C
Discover oncology 2024 Aug 9;15(1):339
Discover oncology 2024 Aug 9;15(1):339
The SGLT2 inhibitor dapagliflozin ameliorates renal fibrosis in hyperuricemic nephropathy.
Hu H, Li W, Hao Y, Peng Z, Zou Z, Wei J, Zhou Y, Liang W, Cao Y
Cell reports. Medicine 2024 Aug 20;5(8):101690
Cell reports. Medicine 2024 Aug 20;5(8):101690
CD146-dependent macrophage infiltration promotes epidural fibrosis via the Erdr1/ERK/CCR2 pathway.
Sun J, Shi M, Song Z, Hua F, Yan X, Zhang M, Duan H, Liu J
International immunopharmacology 2024 Aug 20;137:112528
International immunopharmacology 2024 Aug 20;137:112528
CD47 and IFT57 Are Colinear Genes That Are Highly Coexpressed in Most Cancers and Exhibit Parallel Cancer-Specific Correlations with Survival.
Dong K, Nihal R, Meyer TJ, Singh SP, Kaur S, Roberts DD
International journal of molecular sciences 2024 Aug 17;25(16)
International journal of molecular sciences 2024 Aug 17;25(16)
Peptostreptococcus stomatis promotes colonic tumorigenesis and receptor tyrosine kinase inhibitor resistance by activating ERBB2-MAPK.
Huang P, Ji F, Cheung AH, Fu K, Zhou Q, Ding X, Chen D, Lin Y, Wang L, Jiao Y, Chu ESH, Kang W, To KF, Yu J, Wong CC
Cell host & microbe 2024 Aug 14;32(8):1365-1379.e10
Cell host & microbe 2024 Aug 14;32(8):1365-1379.e10
Single-Cell Analyses Reveal the Metabolic Heterogeneity and Plasticity of the Tumor Microenvironment during Head and Neck Squamous Cell Carcinoma Progression.
Meng X, Zheng Y, Zhang L, Liu P, Liu Z, He Y
Cancer research 2024 Aug 1;84(15):2468-2483
Cancer research 2024 Aug 1;84(15):2468-2483
VDR regulates mitochondrial function as a protective mechanism against renal tubular cell injury in diabetic rats.
Chen H, Zhang H, Li AM, Liu YT, Liu Y, Zhang W, Yang C, Song N, Zhan M, Yang S
Redox biology 2024 Apr;70:103062
Redox biology 2024 Apr;70:103062
BMSC-derived Exosomes Ameliorate Peritoneal Dialysis-associated Peritoneal Fibrosis via the Mir-27a-3p/TP53 Pathway.
Zhao JL, Zhao L, Zhan QN, Liu M, Zhang T, Chu WW
Current medical science 2024 Apr;44(2):333-345
Current medical science 2024 Apr;44(2):333-345
Bone morphogenetic protein 6 (BMP6) antagonises experimental proliferative vitreoretinopathy established by TGF-β2 stimulation in retinal pigment epithelial cells through modulation of the p38 and JNK MAPK pathways.
Liu X, Liu M, Chen L
Cell and tissue research 2024 Apr;396(1):103-117
Cell and tissue research 2024 Apr;396(1):103-117
The regulatory role of the apelin/APJ axis in scarring: Identification of upstream and downstream mechanisms.
Shi N, Wang Y, Xia Z, Zhang J, Jia S, Jiao Y, Wang C, Wang X, Zhao J, Zhang J, Jiang D
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167125
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167125
Therapeutic effects of in vivo administration of an inhibitor of tryptophan 2,3-dioxygenase (680c91) for the treatment of fibroids: a preclinical study.
Chuang TD, Ton N, Rysling S, Quintanilla D, Boos D, Khorram O
Fertility and sterility 2024 Apr;121(4):669-678
Fertility and sterility 2024 Apr;121(4):669-678
Intimomedial tears of the aorta heal by smooth muscle cell-mediated fibrosis without atherosclerosis.
Hassab AH, Hur DJ, Vallabhajosyula P, Tellides G, Assi R
JCI insight 2024 Apr 9;9(9)
JCI insight 2024 Apr 9;9(9)
NBR1-p62-Nrf2 mediates the anti-pulmonary fibrosis effects of protodioscin.
Zeng Q, Wen BB, Liu X, Luo YY, Hu ZG, Huang L, Zhang XH, Huang XT, Zhou TT, Sang XX, Luo YY, Xiong DY, Luo ZQ, Liu W, Tang SY
Chinese medicine 2024 Apr 8;19(1):60
Chinese medicine 2024 Apr 8;19(1):60
DEC1 is involved in circadian rhythm disruption-exacerbated pulmonary fibrosis.
Chen SJ, Yu F, Feng X, Li Q, Jiang YH, Zhao LQ, Cheng PP, Wang M, Song LJ, Liang LM, He XL, Xiong L, Xiang F, Wang X, Ye H, Ma WL
Cell communication and signaling : CCS 2024 Apr 26;22(1):245
Cell communication and signaling : CCS 2024 Apr 26;22(1):245
Jin-Gui-Shen-Qi Wan alleviates fibrosis in mouse diabetic nephropathy via MHC class II.
Liang D, Liu L, Qi Y, Nan F, Huang J, Tang S, Tang J, Chen N
Journal of ethnopharmacology 2024 Apr 24;324:117745
Journal of ethnopharmacology 2024 Apr 24;324:117745
Favipiravir ameliorates bleomycin-induced pulmonary fibrosis by reprogramming M1/M2 macrophage polarization.
Zhang R, Jiang Q, Gao S, Zhang H, Xia Q, Liu B, Zhu J, Jiang H, Zhao R, Dong H, Li X, Zhang Y, Yang C, Gu X, Sun L, Zhou H
International immunopharmacology 2024 Apr 20;131:111774
International immunopharmacology 2024 Apr 20;131:111774
Bioinformatics-based dynamics of cuproptosis -related indicators in experimental silicosis.
Xia J, Wu C, Jin X, Ding M, Zhang C, Hou G, Hao C, Yao W
Ecotoxicology and environmental safety 2024 Apr 15;275:116286
Ecotoxicology and environmental safety 2024 Apr 15;275:116286
Propofol improves ischemia reperfusion-induced liver fibrosis by regulating lncRNA HOXA11-AS.
Luo J, Liu J, Mou Y, Luo F, Liao Q, Liao Y
The Journal of toxicological sciences 2023;48(6):345-354
The Journal of toxicological sciences 2023;48(6):345-354
Up-regulated SPP1 increases the risk from IPF to lung cancer via activating the pro-tumor macrophages.
Chen T, Guo J, Ai L, Wang Y, Wang Y, Chen B, Liu M, Zhuang S, Liu K, Zhao Z, Liang H, Gu Y
Computational and structural biotechnology journal 2023;21:5751-5764
Computational and structural biotechnology journal 2023;21:5751-5764
hucMSC-Ex Alleviates IBD-Associated Intestinal Fibrosis by Inhibiting ERK Phosphorylation in Intestinal Fibroblasts.
Wang Y, Zhang Y, Lu B, Xi J, Ocansey DKW, Mao F, Hao D, Yan Y
Stem cells international 2023;2023:2828981
Stem cells international 2023;2023:2828981
FAT10 Silencing Prevents Liver Fibrosis through Regulating SIRT1 Expression in Hepatic Stellate Cells.
Zheng W, Guan F, Xu G, Yu Y, Xiao J, Huang X
International journal of medical sciences 2023;20(4):557-565
International journal of medical sciences 2023;20(4):557-565
Combining Porous Se@SiO(2) Nanocomposites and dECM Enhances the Myogenic Differentiation of Adipose-Derived Stem Cells.
Zhang YC, Yang YX, Liu Y, Liu XJ, Dai JH, Gao RS, Hu YY, Fei WY
International journal of nanomedicine 2023;18:7661-7676
International journal of nanomedicine 2023;18:7661-7676
Effects of autophagy inhibitor 3-methyladenine on a diabetic mice model.
Ren HW, Yu W, Wang YN, Zhang XY, Song SQ, Gong SY, Meng LY, Gan C, Liu BJ, Gong Q
International journal of ophthalmology 2023;16(9):1456-1464
International journal of ophthalmology 2023;16(9):1456-1464
Irisin Ameliorates Renal Tubulointerstitial Fibrosis by Regulating the Smad4/β-Catenin Pathway in Diabetic Mice.
Yang Z, Wei J, Wang Y, Du Y, Song S, Li J, Su Z, Shi Y, Wu H
Diabetes, metabolic syndrome and obesity : targets and therapy 2023;16:1577-1593
Diabetes, metabolic syndrome and obesity : targets and therapy 2023;16:1577-1593
CXCL5 knockdown attenuated gemcitabine resistance of pancreatic cancer through regulation of cancer cells and tumour stroma.
Lee NH, Ma Y, Ang CS, Dumesny C, Huynh N, Yang Y, Wang K, Nikfarjam M, He H
American journal of translational research 2023;15(4):2676-2689
American journal of translational research 2023;15(4):2676-2689
Identification and validation of chemokine system-related genes in idiopathic pulmonary fibrosis.
Zhao T, Wu X, Zhao X, Yao K, Li X, Ni J
Frontiers in immunology 2023;14:1159856
Frontiers in immunology 2023;14:1159856
Apolipoprotein A-I attenuates peritoneal fibrosis associated with peritoneal dialysis by inhibiting oxidative stress and inflammation.
Lu J, Gao J, Sun J, Wang H, Sun H, Huang Q, Zhang Y, Zhong S
Frontiers in pharmacology 2023;14:1106339
Frontiers in pharmacology 2023;14:1106339
Dapagliflozin alleviates renal fibrosis in a mouse model of adenine-induced renal injury by inhibiting TGF-β1/MAPK mediated mitochondrial damage.
Zeng J, Huang H, Zhang Y, Lv X, Cheng J, Zou SJ, Han Y, Wang S, Gong L, Peng Z
Frontiers in pharmacology 2023;14:1095487
Frontiers in pharmacology 2023;14:1095487
Gastrodin attenuates renal injury and collagen deposition via suppression of the TGF-β1/Smad2/3 signaling pathway based on network pharmacology analysis.
Wen Y, Zhang X, Wei L, Wu M, Cheng Y, Zheng H, Shen A, Fu C, Ali F, Long L, Lu Y, Li J, Peng J
Frontiers in pharmacology 2023;14:1082281
Frontiers in pharmacology 2023;14:1082281
EZH2 and matrix co-regulate phenotype and KCNB2 expression in bladder smooth muscle cells.
Yadav P, Ahmed T, Park S, Sidler M, Schröder A, Aitken KJ, Bägli D
American journal of clinical and experimental urology 2023;11(4):293-303
American journal of clinical and experimental urology 2023;11(4):293-303
Differentially expressed genes in orbital adipose/connective tissue of thyroid-associated orbitopathy.
Wang Y, Liu Y, Cai J, Zong T, Zhang Z, Xie T, Mu T, Wu M, Yang Q, Wang Y, Wang X, Yao Y
PeerJ 2023;11:e16569
PeerJ 2023;11:e16569
Ferroptosis-dependent breast cancer cell-derived exosomes inhibit migration and invasion of breast cancer cells by suppressing M2 macrophage polarization.
Yi C, Wu S, Duan Q, Liu L, Li L, Luo Y, Wang A
PeerJ 2023;11:e15060
PeerJ 2023;11:e15060
Sclareol attenuates liver fibrosis through SENP1-mediated VEGFR2 SUMOylation and inhibition of downstream STAT3 signaling.
Ge MX, Niu WX, Bao YY, Lu ZN, He HW
Phytotherapy research : PTR 2023 Sep;37(9):3898-3912
Phytotherapy research : PTR 2023 Sep;37(9):3898-3912
Embryo-uterine interaction coordinates mouse embryogenesis during implantation.
Bondarenko V, Nikolaev M, Kromm D, Belousov R, Wolny A, Blotenburg M, Zeller P, Rezakhani S, Hugger J, Uhlmann V, Hufnagel L, Kreshuk A, Ellenberg J, van Oudenaarden A, Erzberger A, Lutolf MP, Hiiragi T
The EMBO journal 2023 Sep 4;42(17):e113280
The EMBO journal 2023 Sep 4;42(17):e113280
Omentin-1 induces mechanically activated fibroblasts lipogenic differentiation through pkm2/yap/pparγ pathway to promote lung fibrosis resolution.
Zhang Y, Fu J, Li C, Chang Y, Li X, Cheng H, Qiu Y, Shao M, Han Y, Feng D, Yue S, Sun Z, Luo Z, Zhou Y
Cellular and molecular life sciences : CMLS 2023 Sep 28;80(10):308
Cellular and molecular life sciences : CMLS 2023 Sep 28;80(10):308
Long non-coding RNA MIDEAS-AS1 inhibits growth and metastasis of triple-negative breast cancer via transcriptionally activating NCALD.
Luo D, Liang Y, Wang Y, Ye F, Jin Y, Li Y, Han D, Wang Z, Chen B, Zhao W, Wang L, Chen X, Jiang L, Yang Q
Breast cancer research : BCR 2023 Sep 28;25(1):109
Breast cancer research : BCR 2023 Sep 28;25(1):109
Multi-targeting liposomal codelivery of cisplatin and rapamycin inhibits pancreatic cancer growth and metastasis through stromal modulation.
Zhu W, Yu H, Jia M, Lin C, Yuan Z, Tan X, Yan P
International journal of pharmaceutics 2023 Sep 25;644:123316
International journal of pharmaceutics 2023 Sep 25;644:123316
Fraxin represses NF-κB pathway via inhibiting the activation of epidermal growth factor receptor to ameliorate diabetic renal tubulointerstitial fibrosis.
Zeng J, Liang L, Chen R, Li C, Pan L, Wen M, Lv D, Liu M, Xu Z, Huang H
European journal of pharmacology 2023 Sep 15;955:175915
European journal of pharmacology 2023 Sep 15;955:175915
Targeting STING-mediated pro-inflammatory and pro-fibrotic effects of alveolar macrophages and fibroblasts blunts silicosis caused by silica particles.
Ou L, Zhang P, Huang Z, Cheng Y, Miao Q, Niu R, Hu Y, Chen Y
Journal of hazardous materials 2023 Sep 15;458:131907
Journal of hazardous materials 2023 Sep 15;458:131907
Qingda granule ameliorates vascular remodeling and phenotypic transformation of adventitial fibroblasts via suppressing the TGF-β1/Smad2/3 pathway.
Wu M, Zhang S, Zhang W, Zhou Y, Guo Z, Fang Y, Yang Y, Shen Z, Lian D, Shen A, Peng J
Journal of ethnopharmacology 2023 Sep 15;313:116535
Journal of ethnopharmacology 2023 Sep 15;313:116535
MYCT1 attenuates renal fibrosis and tubular injury in diabetic kidney disease.
Li X, Fan QL, Ma TK, Liu C, Shi H, Sun YY, Wang Y, Ding DX, Tang A, Qin Y, Yang Q, Ding H, Li HY, Fu WN
iScience 2023 Sep 15;26(9):107609
iScience 2023 Sep 15;26(9):107609
Nephroprotective Effects of Cardamonin on Renal Ischemia Reperfusion Injury/UUO-Induced Renal Fibrosis.
Zhang B, Chen ZY, Jiang Z, Huang S, Liu XH, Wang L
Journal of agricultural and food chemistry 2023 Sep 13;71(36):13284-13303
Journal of agricultural and food chemistry 2023 Sep 13;71(36):13284-13303
N-methylpiperazine-diepoxyovatodiolide ameliorates peritoneal fibrosis via suppressing TGF-β/Smad and JAK/STAT signaling pathway.
Mo M, Zeng Y, Zeng Y, Li S, He X, Chen X, Luo Q, Liu M, Luo C, Dou X, Peng F, Long H
Chemico-biological interactions 2023 Sep 1;382:110589
Chemico-biological interactions 2023 Sep 1;382:110589
Ceruloplasmin regulating fibrosis in orbital fibroblasts provides a novel therapeutic target for Graves' orbitopathy.
Cao J, Qi X, Wang N, Chen Y, Xie B, Ma C, Chen Z, Xiong W
Journal of endocrinological investigation 2023 Oct;46(10):2005-2016
Journal of endocrinological investigation 2023 Oct;46(10):2005-2016
Pregnane X receptor activation alleviates renal fibrosis in mice via interacting with p53 and inhibiting the Wnt7a/β-catenin signaling.
Ming WH, Luan ZL, Yao Y, Liu HC, Hu SY, Du CX, Zhang C, Zhao YH, Huang YZ, Sun XW, Qiao RF, Xu H, Guan YF, Zhang XY
Acta pharmacologica Sinica 2023 Oct;44(10):2075-2090
Acta pharmacologica Sinica 2023 Oct;44(10):2075-2090
Nucleosome assembly protein 1 like 1 (NAP1L1) promotes cardiac fibrosis by inhibiting YAP1 ubiquitination and degradation.
Li T, Niu Z, Yu T, Li J, Lu X, Huang M, Wang Q, Yu X, Feng J, Xu B, Bing D, Li X, Lu L, Liang H, Yang R, Wang B, Shan H
MedComm 2023 Oct;4(5):e348
MedComm 2023 Oct;4(5):e348
Can targeted nanoparticles distinguish cancer metastasis from inflammation?
Choi AS, Moon TJ, Abuhashim W, Bhalotia A, Qian H, Paulsen KE, Lorkowski M, Ndamira C, Gopalakrishnan R, Krishnamurthy A, Schiemann WP, Karathanasis E
Journal of controlled release : official journal of the Controlled Release Society 2023 Oct;362:812-819
Journal of controlled release : official journal of the Controlled Release Society 2023 Oct;362:812-819
KCTD4 interacts with CLIC1 to disrupt calcium homeostasis and promote metastasis in esophageal cancer.
Zheng C, Yu X, Xu T, Liu Z, Jiang Z, Xu J, Yang J, Zhang G, He Y, Yang H, Shi X, Li Z, Liu J, Xu WW
Acta pharmaceutica Sinica. B 2023 Oct;13(10):4217-4233
Acta pharmaceutica Sinica. B 2023 Oct;13(10):4217-4233
Fu-Zheng-Tong-Luo formula promotes autophagy and alleviates idiopathic pulmonary fibrosis by controlling the Janus kinase 2/signal transducer and activator of transcription 3 pathway.
Zhang X, Su J, Lin J, Liu L, Wu J, Yuan W, Zhang Y, Chen Q, Su ZJ, Xu G, Sun M, Zhang Y, Chen X, Zhang W
Journal of ethnopharmacology 2023 Oct 5;314:116633
Journal of ethnopharmacology 2023 Oct 5;314:116633
Neuroepithelial cell-transforming 1 promotes cardiac fibrosis via the Wnt/β-catenin signaling pathway.
Li T, Xiong X, Wang Y, Li Y, Liu Y, Zhang M, Li C, Yu T, Cao W, Chen S, Zhang H, Wang X, Lv L, Zhou Y, Liang H, Li X, Shan H
iScience 2023 Oct 20;26(10):107888
iScience 2023 Oct 20;26(10):107888
Proximal Tubular Lats2 Ablation Exacerbates Ischemia/Reperfusion Injury (IRI)-Induced Renal Maladaptive Repair through the Upregulation of P53.
Zhang C, Zheng Z, Xu K, Cheng G, Wu H, Liu J
International journal of molecular sciences 2023 Oct 17;24(20)
International journal of molecular sciences 2023 Oct 17;24(20)
Liraglutide intervention improves high-glucose-induced reactive gliosis of Müller cells and ECM dysregulation.
Shan Y, Gao X, Zhao K, Xu C, Li H, Hu Y, Lin W, Ma X, Xu Q, Kuang H, Hao M
Molecular and cellular endocrinology 2023 Oct 1;576:112013
Molecular and cellular endocrinology 2023 Oct 1;576:112013
Mannan-binding lectin ameliorates renal fibrosis by suppressing macrophage-to-myofibroblast transition.
Xu L, Jiang H, Xie J, Xu Q, Zhou J, Lu X, Wang M, Dong L, Zuo D
Heliyon 2023 Nov;9(11):e21882
Heliyon 2023 Nov;9(11):e21882
Local administration of liposomal-based Plekhf1 gene therapy attenuates pulmonary fibrosis by modulating macrophage polarization.
Yan L, Hou C, Liu J, Wang Y, Zeng C, Yu J, Zhou T, Zhou Q, Duan S, Xiong W
Science China. Life sciences 2023 Nov;66(11):2571-2586
Science China. Life sciences 2023 Nov;66(11):2571-2586
Hyperbranched polyamidoamine-RGD peptide/si-circICA1 in the treatment of invasive thyroid cancer through targeting of the miR-486-3p/SERPINA1 axis.
Dong S, Xia Q, Pan J, Du XL, Wu YJ, Xie XJ
Nanomedicine (London, England) 2023 Nov;18(27):2039-2059
Nanomedicine (London, England) 2023 Nov;18(27):2039-2059
SETD2 deficiency promotes renal fibrosis through the TGF-β/Smad signalling pathway in the absence of VHL.
Liu C, Ni L, Li X, Rao H, Feng W, Zhu Y, Zhang W, Ma C, Xu Y, Gui L, Wang Z, Aji R, Xu J, Gao WQ, Li L
Clinical and translational medicine 2023 Nov;13(11):e1468
Clinical and translational medicine 2023 Nov;13(11):e1468
Melatonin exerts a protective effect in ameliorating nephrolithiasis via targeting AMPK/PINK1-Parkin mediated mitophagy and inhibiting ferroptosis in vivo and in vitro.
Zhou J, Meng L, He Z, Song Q, Liu J, Su X, Wang C, Ke H, Dong C, Liao W, Yang S
International immunopharmacology 2023 Nov;124(Pt A):110801
International immunopharmacology 2023 Nov;124(Pt A):110801
Guanxin V alleviates ventricular remodeling by promoting transforming growth factor-beta 1-mediated proteasomal degradation of Vimentin.
Gu N, Liang B
Poultry science 2023 Nov;102(11):103026
Poultry science 2023 Nov;102(11):103026
Defining the identity and the niches of epithelial stem cells with highly pleiotropic multilineage potency in the human thymus.
Ragazzini R, Boeing S, Zanieri L, Green M, D'Agostino G, Bartolovic K, Agua-Doce A, Greco M, Watson SA, Batsivari A, Ariza-McNaughton L, Gjinovci A, Scoville D, Nam A, Hayday AC, Bonnet D, Bonfanti P
Developmental cell 2023 Nov 20;58(22):2428-2446.e9
Developmental cell 2023 Nov 20;58(22):2428-2446.e9
Prolonged exposure to the herbicide atrazine promotes kidney fibrosis by activating Wnt/β-catenin signaling in rats.
Wang T, Huang X, Liu J, Liu W, Yang Z, He K, Chen J, Zhao L
Environmental toxicology 2023 May;38(5):1143-1152
Environmental toxicology 2023 May;38(5):1143-1152
CircRNA_0017076 acts as a sponge for miR-185-5p in the control of epithelial-to-mesenchymal transition of tubular epithelial cells during renal interstitial fibrosis.
Zhang F, Zou H, Li X, Liu J, Xie Y, Chen M, Yu J, Wu X, Guo B
Human cell 2023 May;36(3):1024-1040
Human cell 2023 May;36(3):1024-1040
Lysine 2-hydroxyisobutyrylation of NAT10 promotes cancer metastasis in an ac4C-dependent manner.
Liao L, He Y, Li SJ, Yu XM, Liu ZC, Liang YY, Yang H, Yang J, Zhang GG, Deng CM, Wei X, Zhu YD, Xu TY, Zheng CC, Cheng C, Li A, Li ZG, Liu JB, Li B
Cell research 2023 May;33(5):355-371
Cell research 2023 May;33(5):355-371
Nicotine exposure exacerbates silica-induced pulmonary fibrosis via STAT3-BDNF-TrkB-mediated epithelial-mesenchymal transition in alveolar type II cells.
Chen H, Tao X, Cao H, Li B, Sun Q, Wang W, Zou Y, Mu M, Tao H, Zhao Y, Ge D
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 May;175:113694
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 May;175:113694
HDAC9-mediated epithelial cell cycle arrest in G2/M contributes to kidney fibrosis in male mice.
Zhang Y, Yang Y, Yang F, Liu X, Zhan P, Wu J, Wang X, Wang Z, Tang W, Sun Y, Zhang Y, Xu Q, Shang J, Zhen J, Liu M, Yi F
Nature communications 2023 May 25;14(1):3007
Nature communications 2023 May 25;14(1):3007
Splicing factor YBX1 regulates bone marrow stromal cell fate during aging.
Xiao Y, Cai GP, Feng X, Li YJ, Guo WH, Guo Q, Huang Y, Su T, Li CJ, Luo XH, Zheng YJ, Yang M
The EMBO journal 2023 May 2;42(9):e111762
The EMBO journal 2023 May 2;42(9):e111762
Crosstalk between the JAK2 and TGF-β1 signaling pathways in scleroderma-related interstitial lung disease targeted by baricitinib.
Wang D, Wei Y, Xu L, Zhang J
Advances in rheumatology (London, England) 2023 May 16;63(1):22
Advances in rheumatology (London, England) 2023 May 16;63(1):22
Ginsenoside Rb1 promotes the activation of PPARα pathway via inhibiting FADD to ameliorate heart failure.
Li C, Zhang X, Li J, Liang L, Zeng J, Wen M, Pan L, Lv D, Liu M, Cheng Y, Huang H
European journal of pharmacology 2023 May 15;947:175676
European journal of pharmacology 2023 May 15;947:175676
USP22 aggravated diabetic renal tubulointerstitial fibrosis progression through deubiquitinating and stabilizing Snail1.
Zhao X, He X, Wei W, Huang K
European journal of pharmacology 2023 May 15;947:175671
European journal of pharmacology 2023 May 15;947:175671
Aristolocholic acid I promotes renal tubular epithelial fibrosis by upregulating matrix metalloproteinase-9 expression via activating the C3a/C3aR axis of macrophages.
Zhang Q, Ye J, Zhang Z, Hu Y, Wang X, Jiang W, Guo X, Chen L, Cheng S, Li J, Zhang L
Toxicology letters 2023 May 15;381:27-35
Toxicology letters 2023 May 15;381:27-35
PRMT2 promotes RCC tumorigenesis and metastasis via enhancing WNT5A transcriptional expression.
Li Z, Chen C, Yong H, Jiang L, Wang P, Meng S, Chu S, Li Z, Guo Q, Zheng J, Bai J, Li H
Cell death & disease 2023 May 12;14(5):322
Cell death & disease 2023 May 12;14(5):322
Yishen Tongluo formula alleviates diabetic kidney disease through regulating Sirt6/TGF-β1/Smad2/3 pathway and promoting degradation of TGF-β1.
Zhang X, Zhao L, Xiang S, Sun Y, Wang P, Chen JJ, Teo BS, Xie Z, Zhang Z, Xu J
Journal of ethnopharmacology 2023 May 10;307:116243
Journal of ethnopharmacology 2023 May 10;307:116243
Interferon regulatory factor 4 deletion protects against kidney inflammation and fibrosis in deoxycorticosterone acetate/salt hypertension.
Gao Y, Liu B, Guo X, Nie J, Zou H, Wen S, Yu W, Liang H
Journal of hypertension 2023 May 1;41(5):794-810
Journal of hypertension 2023 May 1;41(5):794-810
N4-acetylcytidine modification of lncRNA CTC-490G23.2 promotes cancer metastasis through interacting with PTBP1 to increase CD44 alternative splicing.
Yu XM, Li SJ, Yao ZT, Xu JJ, Zheng CC, Liu ZC, Ding PB, Jiang ZL, Wei X, Zhao LP, Shi XY, Li ZG, Xu WW, Li B
Oncogene 2023 Mar;42(14):1101-1116
Oncogene 2023 Mar;42(14):1101-1116
Rapid formation of 3D: Decellularized extracellular matrix spheroids for enhancing bone formation.
Zhang Y, Feng Y, Shao Q, Jiang Z, Yang G
Journal of biomedical materials research. Part A 2023 Mar;111(3):378-388
Journal of biomedical materials research. Part A 2023 Mar;111(3):378-388
Cardioprotective and anti-inflammatory effects of Caveolin 1 in experimental diabetic cardiomyopathy.
Gong W, Jiao Q, Yuan J, Luo H, Liu Y, Zhang Y, Chen Z, Xu X, Bai L, Zhang X
Clinical science (London, England : 1979) 2023 Mar 31;137(6):511-525
Clinical science (London, England : 1979) 2023 Mar 31;137(6):511-525
Sustainably released nanoparticle-based rhynchophylline limits pulmonary fibrosis by inhibiting the TEK-PI3K/AKT signaling pathway.
Wang S, Huang Z, Liu Y, Sun H, Zhou Y, Shi J
Translational lung cancer research 2023 Mar 31;12(3):427-445
Translational lung cancer research 2023 Mar 31;12(3):427-445
Combination of pioglitazone, a PPARγ agonist, and synthetic surfactant B-YL prevents hyperoxia-induced lung injury in adult mice lung explants.
Kurihara C, Sakurai R, Chuang TD, Waring AJ, Walther FJ, Rehan VK
Pulmonary pharmacology & therapeutics 2023 Jun;80:102209
Pulmonary pharmacology & therapeutics 2023 Jun;80:102209
ROS promote hyper-methylation of NDRG2 promoters in a DNMTS-dependent manner: Contributes to the progression of renal fibrosis.
Zhao Y, Fan X, Wang Q, Zhen J, Li X, Zhou P, Lang Y, Sheng Q, Zhang T, Huang T, Zhao Y, Lv Z, Wang R
Redox biology 2023 Jun;62:102674
Redox biology 2023 Jun;62:102674
GPR97 deficiency ameliorates renal interstitial fibrosis in mouse hypertensive nephropathy.
Wu JC, Wang XJ, Zhu JH, Huang XY, Liu M, Qiao Z, Zhang Y, Sun Y, Wang ZY, Zhan P, Zhang T, Hu HL, Liu H, Tang W, Yi F
Acta pharmacologica Sinica 2023 Jun;44(6):1206-1216
Acta pharmacologica Sinica 2023 Jun;44(6):1206-1216
ZNF133 is a potent suppressor in breast carcinogenesis through dampening L1CAM, a driver for tumor progression.
Li L, Wang X, Hu K, Liu X, Qiu L, Bai C, Cui Y, Wang B, Wang Z, Wang H, Cheng R, Hua J, Hai L, Wang M, Liu M, Song Z, Xiao C, Li B
Oncogene 2023 Jun;42(27):2166-2182
Oncogene 2023 Jun;42(27):2166-2182
GYY4137, a H(2)S donor, ameliorates kidney injuries in diabetic mice by modifying renal ROS-associated enzymes.
Chen X, Xiao L, Yu S, Ren Z, Wang W, Jia Y, Liu M, Wang P, Ji D, Yu Y, Wang X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jun;162:114694
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jun;162:114694
Mitochondrial folate pathway regulates myofibroblast differentiation and silica-induced pulmonary fibrosis.
Qu Y, Zhai R, Wang D, Wang Z, Hou G, Wu C, Tang M, Xiao X, Jiao J, Ba Y, Zhou F, Qiu J, Yao W
Journal of translational medicine 2023 Jun 6;21(1):365
Journal of translational medicine 2023 Jun 6;21(1):365
AAV9-Tspyl2 gene therapy retards bleomycin-induced pulmonary fibrosis by modulating downstream TGF-β signaling in mice.
Zhang S, Tong X, Liu S, Huang J, Zhang L, Zhang T, Wang D, Fan H
Cell death & disease 2023 Jun 30;14(6):389
Cell death & disease 2023 Jun 30;14(6):389
GATA zinc finger protein p66β promotes breast cancer cell migration by acting as a co-activator of Snail.
Zou X, Ma L, Zhang Y, Zhang Q, Xu C, Zhang D, Chu Y, Zhang J, Li M, Zhang H, Wang J, Peng C, Wei G, Wu Y, Hou Z, Jia H
Cell death & disease 2023 Jun 28;14(6):382
Cell death & disease 2023 Jun 28;14(6):382
Depletion of CUL4B in macrophages ameliorates diabetic kidney disease via miR-194-5p/ITGA9 axis.
Jin S, Song Y, Zhou L, Jiang W, Qin L, Wang Y, Yu R, Liu Y, Diao Y, Zhang F, Liu K, Li P, Hu H, Jiang B, Tang W, Yi F, Gong Y, Liu G, Sun G
Cell reports 2023 Jun 27;42(6):112550
Cell reports 2023 Jun 27;42(6):112550
PLAGL2 promotes Snail expression and gastric cancer progression via UCA1/miR-145-5p/YTHDF1 axis.
Chen W, He Q, Liu J, Li N, Xiao K, Chen H
Carcinogenesis 2023 Jun 24;44(4):328-340
Carcinogenesis 2023 Jun 24;44(4):328-340
Therapeutic Effects of Long-Term Administration of Tranilast in an Animal Model for the Treatment of Fibroids.
Chuang TD, Munoz L, Quintanilla D, Boos D, Khorram O
International journal of molecular sciences 2023 Jun 21;24(13)
International journal of molecular sciences 2023 Jun 21;24(13)
Genetic lineage tracing reveals stellate cells as contributors to myofibroblasts in pancreas and islet fibrosis.
Wang J, Li T, Zhou Y, Wang X, Carvalho V, Ni C, Li W, Wang Q, Chen Y, Shang Z, Qiu S, Sun Z
iScience 2023 Jun 16;26(6):106988
iScience 2023 Jun 16;26(6):106988
Total flavonoid extract from Dracocephalum moldavica L. improves pulmonary fibrosis by reducing inflammation and inhibiting the hedgehog signaling pathway.
He CH, Lv JM, Khan GJ, Duan H, Wang W, Zhai KF, Zou GA, Aisa HA
Phytotherapy research : PTR 2023 Jul;37(7):2745-2758
Phytotherapy research : PTR 2023 Jul;37(7):2745-2758
Dach1 deficiency drives alveolar epithelium apoptosis in pulmonary fibrosis via modulating C-Jun/Bim activity.
Lu Y, Tang K, Wang S, Tian Z, Fan Y, Li B, Wang M, Zhao J, Xie J
Translational research : the journal of laboratory and clinical medicine 2023 Jul;257:54-65
Translational research : the journal of laboratory and clinical medicine 2023 Jul;257:54-65
Schwann cells regulate tumor cells and cancer-associated fibroblasts in the pancreatic ductal adenocarcinoma microenvironment.
Xue M, Zhu Y, Jiang Y, Han L, Shi M, Su R, Wang L, Xiong C, Wang C, Wang T, Deng S, Wu D, Cao Y, Dong L, Bai F, Zhao S, Deng X, Peng C, Li H, Chen J, Shen B, Jiang L, Chen H
Nature communications 2023 Jul 31;14(1):4600
Nature communications 2023 Jul 31;14(1):4600
Metformin attenuates chronic lung allograft dysfunction: evidence in rat models.
Tian D, Zheng X, Tang H, Huang H, Wang J, Xu L, Li C, Yan H, Yu R, Nan J, Liu M, Guo X, Jian S, Wang T, Deng S, Pu Q, Liu L
Respiratory research 2023 Jul 29;24(1):192
Respiratory research 2023 Jul 29;24(1):192
CXCL17 Attenuates Diesel Exhaust Emissions Exposure-Induced Lung Damage by Regulating Macrophage Function.
Yin Y, Mu C, Wang J, Wang Y, Hu W, Zhu W, Yu X, Hao W, Zheng Y, Li Q, Han W
Toxics 2023 Jul 26;11(8)
Toxics 2023 Jul 26;11(8)
Luteolin inhibits subretinal fibrosis and epithelial-mesenchymal transition in laser-induced mouse model via suppression of Smad2/3 and YAP signaling.
Zhang C, Zhang Y, Hu X, Zhao Z, Chen Z, Wang X, Zhang Z, Jin H, Zhang J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154865
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154865
Fibronectin promotes tumor angiogenesis and progression of non-small-cell lung cancer by elevating WISP3 expression via FAK/MAPK/ HIF-1α axis and activating wnt signaling pathway.
Zhou F, Sun J, Ye L, Jiang T, Li W, Su C, Ren S, Wu F, Zhou C, Gao G
Experimental hematology & oncology 2023 Jul 19;12(1):61
Experimental hematology & oncology 2023 Jul 19;12(1):61
Single-cell RNA sequencing reveals that HSD17B2 in cancer-associated fibroblasts promotes the development and progression of castration-resistant prostate cancer.
Zhang Y, Fan A, Li Y, Liu Z, Yu L, Guo J, Hou J, Li X, Chen W
Cancer letters 2023 Jul 10;566:216244
Cancer letters 2023 Jul 10;566:216244
Tartary buckwheat flavonoids alleviates high-fat diet induced kidney fibrosis in mice by inhibiting MAPK and TGF-β1/Smad signaling pathway.
Liu S, Fu S, Jin Y, Geng R, Li Y, Zhang Y, Liu J, Guo W
Chemico-biological interactions 2023 Jul 1;379:110533
Chemico-biological interactions 2023 Jul 1;379:110533
Quercetin inhibits the amphiregulin/EGFR signaling-mediated renal tubular epithelial-mesenchymal transition and renal fibrosis in obstructive nephropathy.
Wang Q, Wang F, Li X, Ma Z, Jiang D
Phytotherapy research : PTR 2023 Jan;37(1):111-123
Phytotherapy research : PTR 2023 Jan;37(1):111-123
Poly-γ-glutamic acid coating polymeric nanoparticles enhance renal drug distribution and cellular uptake for diabetic nephropathy therapy.
Wang Q, Han S, Zhu Y, Wang G, Chen D
Journal of drug targeting 2023 Jan;31(1):89-99
Journal of drug targeting 2023 Jan;31(1):89-99
Interference of ALOX5 alleviates inflammation and fibrosis in high glucose‑induced renal mesangial cells.
Chen X, Xie H, Liu Y, Ou Q, Deng S
Experimental and therapeutic medicine 2023 Jan;25(1):34
Experimental and therapeutic medicine 2023 Jan;25(1):34
The aggravate role of exosomal circRNA11:120406118|12040782 on macrophage pyroptosis through miR-30b-5p/NLRP3 axis in silica-induced lung fibrosis.
Zhang Q, Ban J, Chang S, Qu H, Chen J, Liu F
International immunopharmacology 2023 Jan;114:109476
International immunopharmacology 2023 Jan;114:109476
Effective-compounds of Jinshui Huanxian formula ameliorates fibroblast activation in pulmonary fibrosis by inhibiting the activation of mTOR signaling.
Li J, Li K, Tian Y, Zhao P, Liu X, Li M, Bai Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;109:154604
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;109:154604
Telocyte-Derived Exosomes Provide an Important Source of Wnts That Inhibits Fibrosis and Supports Regeneration and Repair of Endometrium.
Chen TQ, Wei XJ, Liu HY, Zhan SH, Yang XJ
Cell transplantation 2023 Jan-Dec;32:9636897231212746
Cell transplantation 2023 Jan-Dec;32:9636897231212746
Baicalin prevents fibrosis of human trabecular meshwork cells via inhibiting the MyD88/NF-κB pathway.
Li L, Liu Q, Shi L, Zhou X, Wu W, Wang X, Wang L, Wu Z
European journal of pharmacology 2023 Jan 5;938:175425
European journal of pharmacology 2023 Jan 5;938:175425
Exosomes derived from human adipose mesenchymal stem cells ameliorate hepatic fibrosis by inhibiting PI3K/Akt/mTOR pathway and remodeling choline metabolism.
Zhang Z, Shang J, Yang Q, Dai Z, Liang Y, Lai C, Feng T, Zhong D, Zou H, Sun L, Su Y, Yan S, Chen J, Yao Y, Shi Y, Huang X
Journal of nanobiotechnology 2023 Jan 25;21(1):29
Journal of nanobiotechnology 2023 Jan 25;21(1):29
The miR-103a-3p/TGFBR3 axis regulates TGF-β-induced orbital fibroblast activation and fibrosis in thyroid-eye disease.
Xie B, Xiong W, Zhang F, Wang N, Luo Y, Chen Y, Cao J, Chen Z, Ma C, Chen H
Molecular and cellular endocrinology 2023 Jan 1;559:111780
Molecular and cellular endocrinology 2023 Jan 1;559:111780
A2aR inhibits fibrosis and the EMT process in silicosis by regulating Wnt/β-catenin pathway.
Tian Y, Xia J, Yang G, Li C, Qi Y, Dai K, Wu C, Guo Y, Yao W, Hao C
Ecotoxicology and environmental safety 2023 Jan 1;249:114410
Ecotoxicology and environmental safety 2023 Jan 1;249:114410
VX-765 attenuates silica-induced lung inflammatory injury and fibrosis by modulating alveolar macrophages pyroptosis in mice.
Tao H, Zhao H, Mo A, Shao L, Ge D, Liu J, Hu W, Xu K, Ma Q, Wang W, Wang W, Cao H, Mu M, Tao X, Wang J
Ecotoxicology and environmental safety 2023 Jan 1;249:114359
Ecotoxicology and environmental safety 2023 Jan 1;249:114359
Extracellular HSP90 promotes differentiation of lens epithelial cells to fiber cells by activating LRP1-YAP-PROX1 axis.
Li J, Yu J, Huang W, Sang F, Li J, Ren Y, Huang H, Wang M, Li K, Zhang J, Li H, Cui X, Zhang J, Hu M, Yuan F, Guo W, Zhang F, Mu H, Hu Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Feb;37(2):e22783
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Feb;37(2):e22783
Fyn deficiency inhibits oxidative stress by decreasing c-Cbl-mediated ubiquitination of Sirt1 to attenuate diabetic renal fibrosis.
Li S, Lin Z, Xiao H, Xu Z, Li C, Zeng J, Xie X, Deng L, Huang H
Metabolism: clinical and experimental 2023 Feb;139:155378
Metabolism: clinical and experimental 2023 Feb;139:155378
BMAL1/p53 mediating bronchial epithelial cell autophagy contributes to PM2.5-aggravated asthma.
Chen SJ, Huang Y, Yu F, Feng X, Zheng YY, Li Q, Niu Q, Jiang YH, Zhao LQ, Wang M, Cheng PP, Song LJ, Liang LM, He XL, Xiong L, Xiang F, Wang X, Ma WL, Ye H
Cell communication and signaling : CCS 2023 Feb 20;21(1):39
Cell communication and signaling : CCS 2023 Feb 20;21(1):39
Macrophage-derived GPNMB trapped by fibrotic extracellular matrix promotes pulmonary fibrosis.
Wang J, Zhang X, Long M, Yuan M, Yin J, Luo W, Wang S, Cai Y, Jiang W, Chao J
Communications biology 2023 Feb 2;6(1):136
Communications biology 2023 Feb 2;6(1):136
Mitochondrial dysfunction in macrophages promotes inflammation and suppresses repair after myocardial infarction.
Cai S, Zhao M, Zhou B, Yoshii A, Bugg D, Villet O, Sahu A, Olson GS, Davis J, Tian R
The Journal of clinical investigation 2023 Feb 15;133(4)
The Journal of clinical investigation 2023 Feb 15;133(4)
Stomatin-like protein 2 deficiency exacerbates adverse cardiac remodeling.
Hu Y, Jiang H, Xu Y, Chen G, Fan R, Zhou Y, Liu Y, Yao Y, Liu R, Chen W, Zhang K, Chen X, Wang R, Qiu Z
Cell death discovery 2023 Feb 14;9(1):63
Cell death discovery 2023 Feb 14;9(1):63
RGS1 mediates renal interstitial fibrosis through activation of the inflammatory response.
Lu T, Chen S, Xu J
Archives of biochemistry and biophysics 2023 Dec;750:109744
Archives of biochemistry and biophysics 2023 Dec;750:109744
DLK1 overexpression improves sepsis-induced cardiac dysfunction and fibrosis in mice through the TGF-β1/Smad3 signaling pathway and MMPs.
Zeng N, Jian Z, Xu J, Zheng S, Fan Y, Xiao F
Journal of molecular histology 2023 Dec;54(6):655-664
Journal of molecular histology 2023 Dec;54(6):655-664
Human umbilical cord mesenchymal stem cell exosomes alleviate acute kidney injury by inhibiting pyroptosis in rats and NRK-52E cells.
Wan Y, Yu Y, Yu C, Luo J, Wen S, Shen L, Wei G, Hua Y
Renal failure 2023 Dec;45(1):2221138
Renal failure 2023 Dec;45(1):2221138
LncTUG1 ameliorates renal tubular fibrosis in experimental diabetic nephropathy through the miR-145-5p/dual-specificity phosphatase 6 axis.
Wang T, Cui S, Liu X, Han L, Duan X, Feng S, Zhang S, Li G
Renal failure 2023 Dec;45(1):2173950
Renal failure 2023 Dec;45(1):2173950
LncRNA H19-EZH2 interaction promotes liver fibrosis via reprogramming H3K27me3 profiles.
Li XJ, Zhou F, Li YJ, Xue XY, Qu JR, Fan GF, Liu J, Sun R, Wu JZ, Zheng Q, Liu RP
Acta pharmacologica Sinica 2023 Dec;44(12):2479-2491
Acta pharmacologica Sinica 2023 Dec;44(12):2479-2491
BMAL1 inhibits renal fibrosis and renal interstitial inflammation by targeting the ERK1/2/ELK-1/Egr-1 axis.
Chen W, Zhao S, Xing J, Yu W, Rao T, Zhou X, Ruan Y, Li S, Xia Y, Song T, Zou F, Li W, Cheng F
International immunopharmacology 2023 Dec;125(Pt B):111140
International immunopharmacology 2023 Dec;125(Pt B):111140
Icariside Ⅱ attenuates bleomycin-induced pulmonary fibrosis by modulating macrophage polarization.
Deng L, Ouyang B, Shi H, Yang F, Li S, Xie C, Du W, Hu L, Wei Y, Dong J
Journal of ethnopharmacology 2023 Dec 5;317:116810
Journal of ethnopharmacology 2023 Dec 5;317:116810
TRIOBP modulates β-catenin signaling by regulation of miR-29b in idiopathic pulmonary fibrosis.
Wang L, Zhao W, Xia C, Ma S, Li Z, Wang N, Ding L, Wang Y, Cheng L, Liu H, Yang J, Li Y, Rosas I, Yu G
Cellular and molecular life sciences : CMLS 2023 Dec 29;81(1):13
Cellular and molecular life sciences : CMLS 2023 Dec 29;81(1):13
Stromal and tumor immune microenvironment reprogramming through multifunctional cisplatin-based liposomes boosts the efficacy of anti-PD-1 immunotherapy in pancreatic cancer.
Yu H, Zhu W, Lin C, Jia M, Tan X, Yuan Z, Feng S, Yan P
Biomaterials science 2023 Dec 19;12(1):116-133
Biomaterials science 2023 Dec 19;12(1):116-133
Targeting AKT induced Ferroptosis through FTO/YTHDF2-dependent GPX4 m6A methylation up-regulating and degradating in colorectal cancer.
Zhang G, Mi W, Wang C, Li J, Zhang Y, Liu N, Jiang M, Jia G, Wang F, Yang G, Zhang L, Wang J, Fu Y, Zhang Y
Cell death discovery 2023 Dec 15;9(1):457
Cell death discovery 2023 Dec 15;9(1):457
Squalene epoxidase promotes breast cancer progression by regulating CCNB1 protein stability.
Tuluhong D, Gao H, Li X, Wang L, Zhu Y, Xu C, Wang J, Li H, Li Q, Wang S
Experimental cell research 2023 Dec 1;433(1):113805
Experimental cell research 2023 Dec 1;433(1):113805
Cell and rat serum, urine and tissue metabolomics analysis elucidates the key pathway changes associated with chronic nephropathy and reveals the mechanism of action of rhein.
Wang L, Yu X, Li H, He D, Zeng S, Xiang Z
Chinese medicine 2023 Dec 1;18(1):158
Chinese medicine 2023 Dec 1;18(1):158
Aquaporin 1 is a prognostic marker and inhibits tumour progression through downregulation of Snail expression in intrahepatic cholangiocarcinoma.
Zhuang MQ, Jiang XL, Liu WD, Xie QH, Wang P, Dong LW, Hu HP, Zhou HB, Zhou YB
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2023 Aug;55(8):1133-1140
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2023 Aug;55(8):1133-1140
Testosterone attenuates senile cavernous fibrosis by regulating TGFβR1 and galectin-1 signaling pathways through miR-22-3p.
Hu Z, Zhang Y, Chen J, Luo M, Wang N, Xiao Y, He Q
Molecular and cellular biochemistry 2023 Aug;478(8):1791-1802
Molecular and cellular biochemistry 2023 Aug;478(8):1791-1802
JMJD3 ablation in myeloid cells confers renoprotection in mice with DOCA/salt-induced hypertension.
Gao Y, Yu W, Song J, Nie J, Cui Z, Wen S, Liu B, Liang H
Hypertension research : official journal of the Japanese Society of Hypertension 2023 Aug;46(8):1934-1948
Hypertension research : official journal of the Japanese Society of Hypertension 2023 Aug;46(8):1934-1948
Connexin32 Promotes the Activation of Foxo3a to Ameliorate Diabetic Nephropathy via Inhibiting the Polyubiquitination and Degradation of Sirt1.
Li S, Xiao H, Sun X, Chen Z, Lin Z, Li C, Zeng J, Xu Z, Cheng Y, Huang H
Antioxidants & redox signaling 2023 Aug;39(4-6):241-261
Antioxidants & redox signaling 2023 Aug;39(4-6):241-261
Neonatal-Tissue-Derived Extracellular Vesicle Therapy (NEXT): A Potent Strategy for Precision Regenerative Medicine.
Lou P, Liu S, Wang Y, Lv K, Zhou X, Li L, Zhang Y, Chen Y, Cheng J, Lu Y, Liu J
Advanced materials (Deerfield Beach, Fla.) 2023 Aug;35(33):e2300602
Advanced materials (Deerfield Beach, Fla.) 2023 Aug;35(33):e2300602
Crosstalk between Interleukin-1 Receptor-Like 1 and Transforming Growth Factor-β Receptor Signaling Promotes Renal Fibrosis.
Zhu X, Lu J, Rao J, Ru D, Gao M, Shi D, Cao K, Wen S, Dai C, Wang X, Mi W, Liu L, Zhou H
The American journal of pathology 2023 Aug;193(8):1029-1045
The American journal of pathology 2023 Aug;193(8):1029-1045
USP25 inhibits renal fibrosis by regulating TGFβ-SMAD signaling pathway in Ang II-induced hypertensive mice.
Zhao Y, Chen X, Lin Y, Li Z, Su X, Fan S, Chen Y, Wang X, Liang G
Biochimica et biophysica acta. Molecular basis of disease 2023 Aug;1869(6):166713
Biochimica et biophysica acta. Molecular basis of disease 2023 Aug;1869(6):166713
NQO1 alleviates renal fibrosis by inhibiting the TLR4/NF-κB and TGF-β/Smad signaling pathways in diabetic nephropathy.
Qiu D, Song S, Chen N, Bian Y, Yuan C, Zhang W, Duan H, Shi Y
Cellular signalling 2023 Aug;108:110712
Cellular signalling 2023 Aug;108:110712
T Follicular Helper Cells in Tertiary Lymphoid Structure Contribute to Renal Fibrosis by IL-21.
Luo R, Chang D, Zhang N, Cheng Y, Ge S, Xu G
International journal of molecular sciences 2023 Aug 8;24(16)
International journal of molecular sciences 2023 Aug 8;24(16)
Inhibition of miR-25 Ameliorates Cardiac Dysfunction and Fibrosis by Restoring Krüppel-like Factor 4 Expression.
Lee C, Cho S, Jeong D
International journal of molecular sciences 2023 Aug 4;24(15)
International journal of molecular sciences 2023 Aug 4;24(15)
Biocompatibility and efficacy of prostatic urethral lift in benign prostate hyperplasia: an in vivo and in vitro study.
Xia Y, Yuan T, Zou W, Li H, Ning J, Ruan Y, Xu L, Yu W, Cheng F
Scientific reports 2023 Aug 24;13(1):13828
Scientific reports 2023 Aug 24;13(1):13828
Knockdown of long noncoding RNA SAN rejuvenates aged adipose-derived stem cells via miR-143-3p/ADD3 axis.
Xiong H, Ren S, Chen J, Yang X, Liu Y, Xu Z, Guo J, Jiang T, Yuan M, Liu Y, Zhang G, Li W, Machens HG, Chen Z
Stem cell research & therapy 2023 Aug 21;14(1):213
Stem cell research & therapy 2023 Aug 21;14(1):213
UCP1 alleviates renal interstitial fibrosis progression through oxidative stress pathway mediated by SIRT3 protein stability.
Xiong W, Xiong Z, Song A, Lei C, Ye C, Su H, Zhang C
Journal of translational medicine 2023 Aug 2;21(1):521
Journal of translational medicine 2023 Aug 2;21(1):521
Zanubrutinib Ameliorates Cardiac Fibrosis and Inflammation Induced by Chronic Sympathetic Activation.
Li W, Zhu S, Liu J, Liu Z, Zhou H, Zhang Q, Yang Y, Chen L, Guo X, Zhang T, Meng L, Chai D, Tang G, Li X, Yang C
Molecules (Basel, Switzerland) 2023 Aug 12;28(16)
Molecules (Basel, Switzerland) 2023 Aug 12;28(16)
UMAD1 contributes to ESCRT-III dynamic subunit turnover during cytokinetic abscission.
Glover J, Scourfield EJ, Ventimiglia LN, Yang X, Lynham S, Agromayor M, Martin-Serrano J
Journal of cell science 2023 Aug 1;136(15)
Journal of cell science 2023 Aug 1;136(15)
Lenvatinib inhibited HCC cell migration and invasion through regulating the transcription and ubiquitination of UHRF1 and DNMT1.
Fang T, Jiao Z, You Y, Cao J, Wang C, Liu J, Zhao W
Biochemical pharmacology 2023 Apr;210:115489
Biochemical pharmacology 2023 Apr;210:115489
Qianjin Wenwu decoction suppresses renal interstitial fibrosis by enhancing the degradation of extracellular matrix in mice with unilateral ureteral obstruction.
Jin C, Wu X, You Y, Wang Y, Wu J, Zuo A, Zheng Y, Guo J
Chinese journal of natural medicines 2023 Apr;21(4):253-262
Chinese journal of natural medicines 2023 Apr;21(4):253-262
Characterization of myeloid signature genes for predicting prognosis and immune landscape in Ewing sarcoma.
Zhang Z, Shi Y, Zhu Z, Fu J, Liu D, Liu X, Dang J, Tao H, Fan H
Cancer science 2023 Apr;114(4):1240-1255
Cancer science 2023 Apr;114(4):1240-1255
Two-Pore-Domain Potassium Channel TREK-1 Mediates Pulmonary Fibrosis through Macrophage M2 Polarization and by Direct Promotion of Fibroblast Differentiation.
Zhang Y, Fu J, Han Y, Feng D, Yue S, Zhou Y, Luo Z
Biomedicines 2023 Apr 26;11(5)
Biomedicines 2023 Apr 26;11(5)
Neural and central mechanisms of kidney fibrosis after relief of ureteral obstruction.
Su H, Yang Z, Zhang Y, Yang B, Zhou Z, Su C, Cao W
iScience 2023 Apr 21;26(4):106338
iScience 2023 Apr 21;26(4):106338
CEBPD is a master transcriptional factor for hypoxia regulated proteins in glioblastoma and augments hypoxia induced invasion through extracellular matrix-integrin mediated EGFR/PI3K pathway.
Mao XG, Xue XY, Lv R, Ji A, Shi TY, Chen XY, Jiang XF, Zhang X
Cell death & disease 2023 Apr 14;14(4):269
Cell death & disease 2023 Apr 14;14(4):269
FGF18 promotes human lung branching morphogenesis through regulating mesenchymal progenitor cells.
Danopoulos S, Belgacemi R, Hein RFC, Miller AJ, Deutsch GH, Glass I, Spence JR, Al Alam D
American journal of physiology. Lung cellular and molecular physiology 2023 Apr 1;324(4):L433-L444
American journal of physiology. Lung cellular and molecular physiology 2023 Apr 1;324(4):L433-L444
Senescent renal tubular epithelial cells activate fibroblasts by secreting Shh to promote the progression of diabetic kidney disease.
Wang D, Yin L, Chen R, Tan W, Liang L, Xiang J, Zhang H, Zhou X, Deng H, Guo B, Wang Y
Frontiers in medicine 2022;9:1018298
Frontiers in medicine 2022;9:1018298
Peroxisome Proliferator-Activated Receptor Gene Knockout Promotes Podocyte Injury in Diabetic Mice.
Yan R, Zhang Y, Yang Y, Liu L, Liu L, Guo Z, Yu H, Wang Y, Guo B
BioMed research international 2022;2022:9018379
BioMed research international 2022;2022:9018379
Blockage of Fibronectin 1 Ameliorates Myocardial Ischemia/Reperfusion Injury in Association with Activation of AMP-LKB1-AMPK Signaling Pathway.
Zhang YL, Li PB, Han X, Zhang B, Li HH
Oxidative medicine and cellular longevity 2022;2022:6196173
Oxidative medicine and cellular longevity 2022;2022:6196173
Shenxian-Shengmai Oral Liquid Evoke Autophagy of Fibroblast to Attenuate Sinoatrial Node Fibrosis in Sick Sinus Syndrome Mice via the AKT/mTOR Pathway.
Chen C, Zhang H, Hou S, Liu Y, Ren L, Hao M, Chen K, Li L, Cai X, Deng Z, Liu Z, Hou P
Evidence-based complementary and alternative medicine : eCAM 2022;2022:5219277
Evidence-based complementary and alternative medicine : eCAM 2022;2022:5219277
Panax Notoginseng Saponins Regulate Transforming Growth Factor-β1 through MAPK and Snail/TWIST1 Signaling Pathway to Inhibit Epithelial-Mesenchymal Transition of Pulmonary Fibrosis in A549 Cells.
Nguyen V, Pan F, Zhang G, Zhang Q, Lu Y
Evidence-based complementary and alternative medicine : eCAM 2022;2022:3744618
Evidence-based complementary and alternative medicine : eCAM 2022;2022:3744618
Poly (ADP-ribose) polymerase 1 (PARP1) inhibition promotes pulmonary metastasis of osteosarcoma by boosting ezrin phosphorylation.
Li F, Wu X, Fu X, Liu J, Song W, Xiao GG, Lu A, Zhang G
International journal of biological sciences 2022;18(3):1238-1253
International journal of biological sciences 2022;18(3):1238-1253
NR4A1 inhibits the epithelial-mesenchymal transition of hepatic stellate cells: Involvement of TGF-β-Smad2/3/4-ZEB signaling.
Huang Q, Xu J, Ge Y, Shi Y, Wang F, Zhu M
Open life sciences 2022;17(1):447-454
Open life sciences 2022;17(1):447-454
Endoglin aggravates peritoneal fibrosis by regulating the activation of TGF-β/ALK/Smads signaling.
Huang Q, Xiao R, Lu J, Zhang Y, Xu L, Gao J, Sun J, Wang H
Frontiers in pharmacology 2022;13:973182
Frontiers in pharmacology 2022;13:973182
Inhibition of calpain9 attenuates peritoneal dialysis-related peritoneal fibrosis.
Li F, Wang Y, Tian J, Zhou Z, Yin W, Qin X, Wang H, Zeng T, Li A, Jiang J
Frontiers in pharmacology 2022;13:962770
Frontiers in pharmacology 2022;13:962770
Yi-Shen-Hua-Shi Granule Alleviates Adriamycin-Induced Glomerular Fibrosis by Suppressing the BMP2/Smad Signaling Pathway.
Tan Z, Si Y, Yu Y, Ding J, Huang L, Xu Y, Zhang H, Lu Y, Wang C, Yu B, Yuan L
Frontiers in pharmacology 2022;13:917428
Frontiers in pharmacology 2022;13:917428
ATP-citrate lyase inhibitor improves ectopic lipid accumulation in the kidney in a db/db mouse model.
Zhan Z, Li A, Zhang W, Wu X, He J, Li Z, Li Y, Sun J, Zhang H
Frontiers in endocrinology 2022;13:914865
Frontiers in endocrinology 2022;13:914865
Fraxin Promotes the Activation of Nrf2/ARE Pathway via Increasing the Expression of Connexin43 to Ameliorate Diabetic Renal Fibrosis.
Chen R, Zeng J, Li C, Xiao H, Li S, Lin Z, Huang K, Shen J, Huang H
Frontiers in pharmacology 2022;13:853383
Frontiers in pharmacology 2022;13:853383
Gentiopicroside Ameliorates Diabetic Renal Tubulointerstitial Fibrosis via Inhibiting the AT1R/CK2/NF-κB Pathway.
Xu Z, Zhang M, Wang Y, Chen R, Xu S, Sun X, Yang Y, Lin Z, Wang S, Huang H
Frontiers in pharmacology 2022;13:848915
Frontiers in pharmacology 2022;13:848915
Dihydromyricetin Alleviates Pulmonary Fibrosis by Regulating Abnormal Fibroblasts Through the STAT3/p-STAT3/GLUT1 Signaling Pathway.
Li Z, Geng J, Xie B, He J, Wang J, Peng L, Hu Y, Dai H, Wang C
Frontiers in pharmacology 2022;13:834604
Frontiers in pharmacology 2022;13:834604
Atorvastatin Restores PPARα Inhibition of Lipid Metabolism Disorders by Downregulating miR-21 Expression to Improve Mitochondrial Function and Alleviate Diabetic Nephropathy Progression.
Xiang J, Zhang H, Zhou X, Wang D, Chen R, Tan W, Liang L, Shi M, Zhang F, Xiao Y, Zhou Y, Wang Y, Guo B
Frontiers in pharmacology 2022;13:819787
Frontiers in pharmacology 2022;13:819787
Decreased RNA m(6)A methylation enhances the process of the epithelial mesenchymal transition and vasculogenic mimicry in glioblastoma.
Tao M, Li X, He L, Rong X, Wang H, Pan J, Lu Z, Zhang X, Peng Y
American journal of cancer research 2022;12(2):893-906
American journal of cancer research 2022;12(2):893-906
Nintedanib enhances the efficacy of PD-L1 blockade by upregulating MHC-I and PD-L1 expression in tumor cells.
Tu J, Xu H, Ma L, Li C, Qin W, Chen X, Yi M, Sun L, Liu B, Yuan X
Theranostics 2022;12(2):747-766
Theranostics 2022;12(2):747-766
Blockade of phosphotyrosine pathways suggesting SH2 superbinder as a novel therapy for pulmonary fibrosis.
Wang M, Liu AD, Niu Q, Feng X, Zheng YY, Chen SJ, Xu H, Li Q, Hou GQ, Bi XY, Lu YZ, Cheng PP, Liang LM, Jiang YH, Zhao LQ, Liu F, Song LJ, Zhou LL, Xiao LY, Chen F, Li SS, Ma WL, Cao X, Ye H
Theranostics 2022;12(10):4513-4535
Theranostics 2022;12(10):4513-4535
Establishment and characterization of an immortalized epithelial cell line from human gallbladder.
Wang Z, Wang S, Jia Z, Zhao Y, Yang M, Yan W, Chen T, Xiang D, Shao R, Liu Y
Frontiers in oncology 2022;12:994087
Frontiers in oncology 2022;12:994087
Chordin-Like 1 Regulates Epithelial-to-Mesenchymal Transition and Metastasis via the MAPK Signaling Pathway in Oral Squamous Cell Carcinoma.
Wu Q, Zheng Z, Zhang J, Piao Z, Xin M, Xiang X, Wu A, Zhao T, Huang S, Qiao Y, Zhou J, Xu S, Cheng H, Wu L, Ouyang K
Frontiers in oncology 2022;12:862751
Frontiers in oncology 2022;12:862751
ATP11A promotes EMT by regulating Numb PRR(L) in pancreatic cancer cells.
Chen L, Tang J, Sheng W, Sun J, Ma Y, Dong M
PeerJ 2022;10:e13172
PeerJ 2022;10:e13172
Long Noncoding RNA CTD-2589M5.4 Inhibits Ovarian Cancer Cell Proliferation, Migration, and Invasion Via Downregulation of the Extracellular Matrix-Receptor Interaction Pathway.
Gu Y, Huang K, Zhang M, Teng F, Ge L, Zhou J, Xu J, Jia X
Cancer biotherapy & radiopharmaceuticals 2022 Sep;37(7):580-588
Cancer biotherapy & radiopharmaceuticals 2022 Sep;37(7):580-588
Imatinib inhibits pericyte-fibroblast transition and inflammation and promotes axon regeneration by blocking the PDGF-BB/PDGFRβ pathway in spinal cord injury.
Yao F, Luo Y, Liu YC, Chen YH, Li YT, Hu XY, You XY, Yu SS, Li ZY, Chen L, Tian DS, Zheng MG, Cheng L, Jing JH
Inflammation and regeneration 2022 Sep 26;42(1):44
Inflammation and regeneration 2022 Sep 26;42(1):44
PKM2 promotes pulmonary fibrosis by stabilizing TGF-β1 receptor I and enhancing TGF-β1 signaling.
Gao S, Li X, Jiang Q, Liang Q, Zhang F, Li S, Zhang R, Luan J, Zhu J, Gu X, Xiao T, Huang H, Chen S, Ning W, Yang G, Yang C, Zhou H
Science advances 2022 Sep 23;8(38):eabo0987
Science advances 2022 Sep 23;8(38):eabo0987
miR-124- and let-7-Mediated Reprogram of Human Fibroblasts into SST Interneurons.
Gu X, Wang J, Jiang X
ACS chemical neuroscience 2022 Sep 21;13(18):2755-2765
ACS chemical neuroscience 2022 Sep 21;13(18):2755-2765
RO4929097, a Selective γ-Secretase Inhibitor, Inhibits Subretinal Fibrosis Via Suppressing Notch and ERK1/2 Signaling in Laser-Induced Mouse Model.
Zhang C, Qin S, Xie H, Qiu Q, Wang H, Zhang J, Luo D, Zhang J
Investigative ophthalmology & visual science 2022 Sep 1;63(10):14
Investigative ophthalmology & visual science 2022 Sep 1;63(10):14
The Apelin-APJ axis alleviates LPS-induced pulmonary fibrosis and endothelial mesenchymal transformation in mice by promoting Angiotensin-Converting Enzyme 2.
Wang H, Cong L, Yin X, Zhang N, Zhu M, Sun T, Fan J, Xue F, Fan X, Gong Y
Cellular signalling 2022 Oct;98:110418
Cellular signalling 2022 Oct;98:110418
HC-1119, a deuterated Enzalutamide, inhibits Migration, Invasion and Metastasis of the AR-positive triple-negative breast Cancer cells.
Wu X, Feng W, Yang M, Liu X, Gao M, Li X, Gan L, He T
Molecular biology reports 2022 Oct;49(10):9231-9240
Molecular biology reports 2022 Oct;49(10):9231-9240
Anti-inflammatory potential of stevia residue extract against uric acid-associated renal injury in mice.
Mehmood A, Althobaiti F, Zhao L, Usman M, Chen X, Alharthi F, Soliman MM, Shah AA, Murtaza MA, Nadeem M, Ranjha MMAN, Wang C
Journal of food biochemistry 2022 Oct;46(10):e14286
Journal of food biochemistry 2022 Oct;46(10):e14286
Sestrin2 attenuates renal damage by regulating Hippo pathway in diabetic nephropathy.
Bian Y, Shi C, Song S, Mu L, Wu M, Qiu D, Dong J, Zhang W, Yuan C, Wang D, Zhou Z, Dong X, Shi Y
Cell and tissue research 2022 Oct;390(1):93-112
Cell and tissue research 2022 Oct;390(1):93-112
A network pharmacology-based study on the mechanism of astragaloside IV alleviating renal fibrosis through the AKT1/GSK-3β pathway.
Yu X, Xiao Q, Yu X, Cheng Y, Lin H, Xiang Z
Journal of ethnopharmacology 2022 Oct 28;297:115535
Journal of ethnopharmacology 2022 Oct 28;297:115535
Molecular Regulation of Heme Oxygenase-1 Expression by E2F Transcription Factor 2 in Lung Fibroblast Cells: Relevance to Idiopathic Pulmonary Fibrosis.
Ye Q, Taleb SJ, Wang H, Parinandi NL, Kass DJ, Rojas M, Wang C, Ma Q, Zhao J, Zhao Y
Biomolecules 2022 Oct 21;12(10)
Biomolecules 2022 Oct 21;12(10)
RNF2 mediates pulmonary fibroblasts activation and proliferation by regulating mTOR and p16-CDK4-Rb1 signaling pathway.
Pan L, Hu Y, Qian C, Yao Y, Wang S, Shi W, Xu T
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2022 Nov;71(10-11):1283-1303
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2022 Nov;71(10-11):1283-1303
Critical role of PAFR/YAP1 positive feedback loop in cardiac fibrosis.
Li TY, Su W, Li LL, Zhao XG, Yang N, Gai JX, Lv X, Zhang J, Huang MQ, Zhang Q, Ji WH, Song XY, Zhou YH, Li XL, Shan HL, Liang HH
Acta pharmacologica Sinica 2022 Nov;43(11):2862-2872
Acta pharmacologica Sinica 2022 Nov;43(11):2862-2872
Endophilin A2 protects against renal fibrosis by targeting TGF-β/Smad signaling.
Mai X, Shang J, Chen Q, Gu S, Hong Y, Zhou J, Zhang M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Nov;36(11):e22603
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Nov;36(11):e22603
Apigenin inhibits fibrous scar formation after acute spinal cord injury through TGFβ/SMADs signaling pathway.
Jin Z, Tian L, Zhang Y, Zhang X, Kang J, Dong H, Huang N, Pan L, Ning B
CNS neuroscience & therapeutics 2022 Nov;28(11):1883-1894
CNS neuroscience & therapeutics 2022 Nov;28(11):1883-1894
Si-Wu-Tang ameliorates bile duct ligation-induced liver fibrosis via modulating immune environment.
Ma Z, Xue X, Bai J, Cai Y, Jin X, Jia K, Ding M, Lyu X, Li X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Nov;155:113834
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Nov;155:113834
Lysophosphatidylcholine acyltransferase 1 alleviates silica-induced pulmonary fibrosis by modulating lipid metabolism.
Deng X, Hao C, Li Y, Guo Y, Si H, He J, Deng M, Niu Z, Wang C, Xu X, Dai K, Yao W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Nov;155:113638
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Nov;155:113638
Blockade of the pentraxin 3/CD44 interaction attenuates lung injury-induced fibrosis.
Chi JY, Hsiao YW, Liang HY, Huang TH, Chen FW, Chen CY, Ko CY, Cheng CC, Wang JM
Clinical and translational medicine 2022 Nov;12(11):e1099
Clinical and translational medicine 2022 Nov;12(11):e1099
Intracellular hydroxyproline imprinting following resolution of bleomycin-induced pulmonary fibrosis.
Song S, Fu Z, Guan R, Zhao J, Yang P, Li Y, Yin H, Lai Y, Gong G, Zhao S, Yu J, Peng X, He Y, Luo Y, Zhong N, Su J
The European respiratory journal 2022 May;59(5)
The European respiratory journal 2022 May;59(5)
Single-Cell RNA Sequencing Technology Revealed the Pivotal Role of Fibroblast Heterogeneity in Angiotensin II-Induced Abdominal Aortic Aneurysms.
Weng Y, Lou J, Bao Y, Cai C, Zhu K, Du C, Chen X, Tang L
DNA and cell biology 2022 May;41(5):498-520
DNA and cell biology 2022 May;41(5):498-520
Clusterin as a serum biomarker candidate contributes to the lung fibroblasts activation in chronic obstructive pulmonary disease.
Zhang Q, Yue Y, Zheng R
Chinese medical journal 2022 May 5;135(9):1076-1086
Chinese medical journal 2022 May 5;135(9):1076-1086
Asiatic acid from Cyclocarya paliurus regulates the autophagy-lysosome system via directly inhibiting TGF-β type I receptor and ameliorates diabetic nephropathy fibrosis.
Zhang XX, Liu Y, Xu SS, Yang R, Jiang CH, Zhu LP, Xu YY, Pan K, Zhang J, Yin ZQ
Food & function 2022 May 23;13(10):5536-5546
Food & function 2022 May 23;13(10):5536-5546
Reversing insufficient photothermal therapy-induced tumor relapse and metastasis by regulating cancer-associated fibroblasts.
Li X, Yong T, Wei Z, Bie N, Zhang X, Zhan G, Li J, Qin J, Yu J, Zhang B, Gan L, Yang X
Nature communications 2022 May 19;13(1):2794
Nature communications 2022 May 19;13(1):2794
Human epididymis protein 4 aggravates airway inflammation and remodeling in chronic obstructive pulmonary disease.
Zhan Y, Chen J, Wu J, Gu Y, Huang Q, Deng Z, Chen S, Wu X, Lv Y, Zeng Z, Xie J
Respiratory research 2022 May 12;23(1):120
Respiratory research 2022 May 12;23(1):120
Drug-eluting intraocular lens with sustained bromfenac release for conquering posterior capsular opacification.
Zhang X, Lai K, Li S, Wang J, Li J, Wang W, Ni S, Lu B, Grzybowski A, Ji J, Han H, Yao K
Bioactive materials 2022 Mar;9:343-357
Bioactive materials 2022 Mar;9:343-357
Selenium Deficiency Leads to Changes in Renal Fibrosis Marker Proteins and Wnt/β-Catenin Signaling Pathway Components.
Lin T, Tao J, Chen Y, Zhang Y, Li F, Zhang Y, Han X, Zhao Z, Liu G, Li H
Biological trace element research 2022 Mar;200(3):1127-1139
Biological trace element research 2022 Mar;200(3):1127-1139
Malfunction of airway basal stem cells plays a crucial role in pathophysiology of tracheobronchopathia osteoplastica.
Hong Y, Shan S, Gu Y, Huang H, Zhang Q, Han Y, Dong Y, Liu Z, Huang M, Ren T
Nature communications 2022 Mar 14;13(1):1309
Nature communications 2022 Mar 14;13(1):1309
A rapid and simple procedure for the isolation and cultivation of fibroblast-like cells from medaka and zebrafish embryos and fin clip biopsies.
Beedgen L, Hüllen A, Gücüm S, Thumberger T, Wittbrodt J, Thiel C
Laboratory animals 2022 Jun;56(3):270-278
Laboratory animals 2022 Jun;56(3):270-278
Atorvastatin reduces IOP in ocular hypertension in vivo and suppresses ECM in trabecular meshwork perhaps via FGD4.
Song XY, Chen YY, Liu WT, Cong L, Zhang JL, Zhang Y, Zhang YY
International journal of molecular medicine 2022 Jun;49(6)
International journal of molecular medicine 2022 Jun;49(6)
Schwann cell‑like cells derived from human amniotic mesenchymal stem cells promote sciatic nerve repair through an exosome‑induced SOX2/FN1 pathway in vitro.
Chen W, Chang S, Yang C, Zhou J, Zhang H, Nie K, Wei Z
International journal of molecular medicine 2022 Jun;49(6)
International journal of molecular medicine 2022 Jun;49(6)
CHIR99021 balance TGFβ1 induced human corneal endothelial-to-mesenchymal transition to favor corneal endothelial cell proliferation.
Wang Y, Jin C, Tian H, Xu J, Chen J, Hu S, Li Q, Lu L, Ou Q, Xu GT, Cui H
Experimental eye research 2022 Jun;219:108939
Experimental eye research 2022 Jun;219:108939
IL-33 Promotes ST2-Dependent Fibroblast Maturation via P38 and TGF-β in a Mouse Model of Epidural Fibrosis.
Wang H, Wu T, Hua F, Sun J, Bai Y, Wang W, Liu J, Zhang M
Tissue engineering and regenerative medicine 2022 Jun;19(3):577-588
Tissue engineering and regenerative medicine 2022 Jun;19(3):577-588
Blockade of TMEM16A protects against renal fibrosis by reducing intracellular Cl(-) concentration.
Li XL, Liu J, Chen XS, Cheng LM, Liu WL, Chen XF, Li YJ, Guan YY, Zeng X, Du YH
British journal of pharmacology 2022 Jun;179(12):3043-3060
British journal of pharmacology 2022 Jun;179(12):3043-3060
The miRNA-34a/Sirt1/p53 pathway in a rat model of lens regeneration.
Bi X, Wang R, Song H, Wang Y, Hao P, Li X
Annals of translational medicine 2022 Jun;10(11):636
Annals of translational medicine 2022 Jun;10(11):636
Novel Thermosensitive Hydrogel Promotes Spinal Cord Repair by Regulating Mitochondrial Function.
Li Y, Yang L, Hu F, Xu J, Ye J, Liu S, Wang L, Zhuo M, Ran B, Zhang H, Ye J, Xiao J
ACS applied materials & interfaces 2022 Jun 8;14(22):25155-25172
ACS applied materials & interfaces 2022 Jun 8;14(22):25155-25172
Single-Cell Transcriptomic Analysis of the Mouse Pancreas: Characteristic Features of Pancreatic Ductal Cells in Chronic Pancreatitis.
Mao X, Mao S, Wang L, Jiang H, Deng S, Wang Y, Ye J, Li Z, Zou W, Liao Z
Genes 2022 Jun 5;13(6)
Genes 2022 Jun 5;13(6)
Systematic analyses identify the anti-fibrotic role of lncRNA TP53TG1 in IPF.
Sun J, Guo Y, Chen T, Jin T, Ma L, Ai L, Guo J, Niu Z, Yang R, Wang Q, Yu X, Gao H, Zhang Y, Su W, Song X, Ji W, Zhang Q, Huang M, Fan X, Du Z, Liang H
Cell death & disease 2022 Jun 4;13(6):525
Cell death & disease 2022 Jun 4;13(6):525
Human amniotic fluid mesenchymal stem cells attenuate pancreatic cancer cell proliferation and tumor growth in an orthotopic xenograft mouse model.
Chen YC, Lan YW, Huang SM, Yen CC, Chen W, Wu WJ, Staniczek T, Chong KY, Chen CM
Stem cell research & therapy 2022 Jun 3;13(1):235
Stem cell research & therapy 2022 Jun 3;13(1):235
A signature of circadian rhythm genes in driving anaplastic thyroid carcinoma malignant progression.
Xu T, Jin T, Lu X, Pan Z, Tan Z, Zheng C, Liu Y, Hu X, Ba L, Ren H, Chen J, Zhu C, Ge M, Huang P
Cellular signalling 2022 Jul;95:110332
Cellular signalling 2022 Jul;95:110332
Gankyrin modulated non-small cell lung cancer progression via glycolysis metabolism in a YAP1-dependent manner.
Yu T, Liu Y, Xue J, Sun X, Zhu D, Ma L, Guo Y, Jin T, Cao H, Chen Y, Zhu T, Li X, Liang H, Du Z, Shan H
Cell death discovery 2022 Jul 9;8(1):312
Cell death discovery 2022 Jul 9;8(1):312
Reprogramming of Rat Fibroblasts into Induced Neurons by Small-Molecule Compounds In Vitro and In Vivo.
Wang X, Wu J, Wang W, Zhang Y, He D, Xiao B, Zhang H, Song A, Xing Y, Li B
ACS chemical neuroscience 2022 Jul 20;13(14):2099-2109
ACS chemical neuroscience 2022 Jul 20;13(14):2099-2109
Identification of the active compounds and functional mechanisms of Jinshui Huanxian formula in pulmonary fibrosis by integrating serum pharmacochemistry with network pharmacology.
Shao D, Liu X, Wu J, Zhang A, Bai Y, Zhao P, Li J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jul 20;102:154177
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jul 20;102:154177
ZEB2/TWIST1/PRMT5/NuRD Multicomplex Contributes to the Epigenetic Regulation of EMT and Metastasis in Colorectal Carcinoma.
Zheng Y, Dai M, Dong Y, Yu H, Liu T, Feng X, Yu B, Zhang H, Wu J, Kong W, Yu X, Wu H
Cancers 2022 Jul 14;14(14)
Cancers 2022 Jul 14;14(14)
Hexavalent chromium triggers hepatocytes premature senescence via the GATA4/NF-κB signaling pathway mediated by the DNA damage response.
Ma Y, Li S, Ye S, Hu D, Wei L, Xiao F
Ecotoxicology and environmental safety 2022 Jul 1;239:113645
Ecotoxicology and environmental safety 2022 Jul 1;239:113645
Collagen has a unique SEC24 preference for efficient export from the endoplasmic reticulum.
Lu CL, Ortmeier S, Brudvig J, Moretti T, Cain J, Boyadjiev SA, Weimer JM, Kim J
Traffic (Copenhagen, Denmark) 2022 Jan;23(1):81-93
Traffic (Copenhagen, Denmark) 2022 Jan;23(1):81-93
Doxorubicin promotes breast cancer cell migration and invasion via DCAF13.
Sun Z, Zhou D, Yang J, Zhang D
FEBS open bio 2022 Jan;12(1):221-230
FEBS open bio 2022 Jan;12(1):221-230
AIM2 inflammasome contributes to aldosterone-induced renal injury via endoplasmic reticulum stress.
Wu Y, Yang H, Xu S, Cheng M, Gu J, Zhang W, Liu S, Zhang M
Clinical science (London, England : 1979) 2022 Jan 14;136(1):103-120
Clinical science (London, England : 1979) 2022 Jan 14;136(1):103-120
Identification of Pyruvate Carboxylase as the Cellular Target of Natural Bibenzyls with Potent Anticancer Activity against Hepatocellular Carcinoma via Metabolic Reprogramming.
Sheng Y, Chen Y, Zeng Z, Wu W, Wang J, Ma Y, Lin Y, Zhang J, Huang Y, Li W, Zhu Q, Wei X, Li S, Wisanwattana W, Li F, Liu W, Suksamrarn A, Zhang G, Jiao W, Wang F
Journal of medicinal chemistry 2022 Jan 13;65(1):460-484
Journal of medicinal chemistry 2022 Jan 13;65(1):460-484
Overexpression of bone morphogenetic protein receptor type 2 suppresses transforming growth factor β-induced profibrotic responses in lung fibroblasts.
Fukihara J, Maiolo S, Kovac J, Sakamoto K, Wakahara K, Hashimoto N, Reynolds PN
Experimental lung research 2022 Feb;48(1):35-51
Experimental lung research 2022 Feb;48(1):35-51
Connexin32 ameliorates epithelial-to-mesenchymal-transition in diabetic renal tubular via inhibiting NOX4.
Sun X, Xiao H, Li S, Chen R, Lin Z, Yang Y, Chen Z, Deng L, Huang H
Pharmacological research 2022 Feb;176:106084
Pharmacological research 2022 Feb;176:106084
Norepinephrine promotes glioma cell migration through up-regulating the expression of Twist1.
Wang X, Wang Y, Xie F, Song ZT, Zhang ZQ, Zhao Y, Wang SD, Hu H, Zhang YS, Qian LJ
BMC cancer 2022 Feb 26;22(1):213
BMC cancer 2022 Feb 26;22(1):213
Numb-PRRL promotes TGF-β1- and EGF-induced epithelial-to-mesenchymal transition in pancreatic cancer.
Sheng W, Tang J, Cao R, Shi X, Ma Y, Dong M
Cell death & disease 2022 Feb 23;13(2):173
Cell death & disease 2022 Feb 23;13(2):173
The HDAC2/SP1/miR-205 feedback loop contributes to tubular epithelial cell extracellular matrix production in diabetic kidney disease.
Zheng Z, Zhang S, Chen J, Zou M, Yang Y, Lu W, Ren S, Wang X, Dong W, Zhang Z, Wang L, Guan M, Cheing GLY, Xue Y, Jia Y
Clinical science (London, England : 1979) 2022 Feb 11;136(3):223-238
Clinical science (London, England : 1979) 2022 Feb 11;136(3):223-238
Necroptosis in pulmonary macrophages promotes silica-induced inflammation and interstitial fibrosis in mice.
Tao H, Zhao H, Ge D, Liao J, Shao L, Mo A, Hu L, Xu K, Wu J, Mu M, Li B, Tao X, Wang J
Toxicology letters 2022 Feb 1;355:150-159
Toxicology letters 2022 Feb 1;355:150-159
Baicalin protects against renal interstitial fibrosis in mice by inhibiting the TGF-β/Smad signalling pathway.
Wang H, Jiang Q, Zhang L
Pharmaceutical biology 2022 Dec;60(1):1407-1416
Pharmaceutical biology 2022 Dec;60(1):1407-1416
Improving the circulation time and renal therapeutic potency of extracellular vesicles using an endogenous ligand binding strategy.
Liu S, Lv K, Wang Y, Lou P, Zhou P, Wang C, Li L, Liao G, Zhang Y, Chen Y, Cheng J, Lu Y, Liu J
Journal of controlled release : official journal of the Controlled Release Society 2022 Dec;352:1009-1023
Journal of controlled release : official journal of the Controlled Release Society 2022 Dec;352:1009-1023
Carbon dots enhance extracellular matrix secretion for dentin-pulp complex regeneration through PI3K/Akt/mTOR pathway-mediated activation of autophagy.
Liu L, Li X, Bu W, Jin N, Meng Y, Wang Y, Wang D, Xu X, Zhou D, Sun H
Materials today. Bio 2022 Dec;16:100344
Materials today. Bio 2022 Dec;16:100344
Astrocyte-derived sEVs alleviate fibrosis and promote functional recovery after spinal cord injury in rats.
Lu Y, Chen C, Wang H, Du R, Ji J, Xu T, Yang C, Chen X
International immunopharmacology 2022 Dec;113(Pt A):109322
International immunopharmacology 2022 Dec;113(Pt A):109322
Zanubrutinib attenuates bleomycin-induced pulmonary fibrosis by inhibiting the TGF-β1 signaling pathway.
Chen S, Wei Y, Li S, Miao Y, Gu J, Cui Y, Liu Z, Liang J, Wei L, Li X, Zhou H, Yang C
International immunopharmacology 2022 Dec;113(Pt A):109316
International immunopharmacology 2022 Dec;113(Pt A):109316
TIPARP is involved in the regulation of intraocular pressure.
Zhang Y, Song M, Bi Y, Lei Y, Sun X, Chen Y
Communications biology 2022 Dec 19;5(1):1386
Communications biology 2022 Dec 19;5(1):1386
Metformin Improves Burn Wound Healing by Modulating Microenvironmental Fibroblasts and Macrophages.
Shi L, Jiang Z, Li J, Lin H, Xu B, Liao X, Fu Z, Ao H, Guo G, Liu M
Cells 2022 Dec 16;11(24)
Cells 2022 Dec 16;11(24)
Macrophages regulate vascular smooth muscle cell function during atherosclerosis progression through IL-1β/STAT3 signaling.
Xue Y, Luo M, Hu X, Li X, Shen J, Zhu W, Huang L, Hu Y, Guo Y, Liu L, Wang L, Luo S
Communications biology 2022 Dec 1;5(1):1316
Communications biology 2022 Dec 1;5(1):1316
Tetramethylpyrazine prevents liver fibrotic injury in mice by targeting hepatocyte-derived and mitochondrial DNA-enriched extracellular vesicles.
Li YJ, Liu RP, Ding MN, Zheng Q, Wu JZ, Xue XY, Gu YQ, Ma BN, Cai YJ, Li S, Lin S, Zhang LY, Li X
Acta pharmacologica Sinica 2022 Aug;43(8):2026-2041
Acta pharmacologica Sinica 2022 Aug;43(8):2026-2041
Ferrostatin‑1 alleviates oxalate‑induced renal tubular epithelial cell injury, fibrosis and calcium oxalate stone formation by inhibiting ferroptosis.
Xie J, Ye Z, Li L, Xia Y, Yuan R, Ruan Y, Zhou X
Molecular medicine reports 2022 Aug;26(2)
Molecular medicine reports 2022 Aug;26(2)
Krill Oil Turns Off TGF-β1 Profibrotic Signaling in the Prevention of Diabetic Nephropathy.
Sun X, Yang Y, Sun X, Meng H, Hao W, Yin J, Ma F, Guo X, Du L, Sun L, Wu H
Journal of agricultural and food chemistry 2022 Aug 17;70(32):9865-9876
Journal of agricultural and food chemistry 2022 Aug 17;70(32):9865-9876
Tubular epithelial cell-derived extracellular vesicles induce macrophage glycolysis by stabilizing HIF-1α in diabetic kidney disease.
Jia Y, Chen J, Zheng Z, Tao Y, Zhang S, Zou M, Yang Y, Xue M, Hu F, Li Y, Zhang Q, Xue Y, Zheng Z
Molecular medicine (Cambridge, Mass.) 2022 Aug 12;28(1):95
Molecular medicine (Cambridge, Mass.) 2022 Aug 12;28(1):95
Comparison of Gene Expression Patterns in Articular Cartilage and Xiphoid Cartilage.
Yao B, Zhou Z, Zhang M, Leng X, Zhao D
Biochemical genetics 2022 Apr;60(2):676-706
Biochemical genetics 2022 Apr;60(2):676-706
Inhibition of RUNX1 blocks the differentiation of lung fibroblasts to myofibroblasts.
Dubey S, Dubey PK, Umeshappa CS, Ghebre YT, Krishnamurthy P
Journal of cellular physiology 2022 Apr;237(4):2169-2182
Journal of cellular physiology 2022 Apr;237(4):2169-2182
Botox-A improve the thyroid-associated ophthalmopathy (TAO) orbital fibroblast activation through inhibiting the TGF-β/Smad signaling.
Qi X, Luo B, Deng M, Cao J, Hou S, Xie Z, Tong B, Xiong W
Experimental eye research 2022 Apr;217:108971
Experimental eye research 2022 Apr;217:108971
Exosomes from human adipose-derived mesenchymal stem cells inhibit production of extracellular matrix in keloid fibroblasts via downregulating transforming growth factor-β2 and Notch-1 expression.
Li J, Li Z, Wang S, Bi J, Huo R
Bioengineered 2022 Apr;13(4):8515-8525
Bioengineered 2022 Apr;13(4):8515-8525
Cigarette smoke-induced oxidative stress activates NRF2 to mediate fibronectin disorganization in vascular formation.
Xue J, Liao Q, Luo M, Hua C, Zhao J, Yu G, Chen X, Li X, Zhang X, Ran R, Lu F, Wang Y, Qiao L
Open biology 2022 Apr;12(4):210310
Open biology 2022 Apr;12(4):210310
SU16f inhibits fibrotic scar formation and facilitates axon regeneration and locomotor function recovery after spinal cord injury by blocking the PDGFRβ pathway.
Li Z, Yu S, Liu Y, Hu X, Li Y, Xiao Z, Chen Y, Tian D, Xu X, Cheng L, Zheng M, Jing J
Journal of neuroinflammation 2022 Apr 16;19(1):95
Journal of neuroinflammation 2022 Apr 16;19(1):95
Hexachlorophene, a selective SHP2 inhibitor, suppresses proliferation and metastasis of KRAS-mutant NSCLC cells by inhibiting RAS/MEK/ERK and PI3K/AKT signaling pathways.
Fu NJ, Xi RY, Shi XK, Li RZ, Zhang ZH, Li LY, Zhang GL, Wang F
Toxicology and applied pharmacology 2022 Apr 15;441:115988
Toxicology and applied pharmacology 2022 Apr 15;441:115988
Integrin β3 Induction Promotes Tubular Cell Senescence and Kidney Fibrosis.
Li S, Jiang S, Zhang Q, Jin B, Lv D, Li W, Zhao M, Jiang C, Dai C, Liu Z
Frontiers in cell and developmental biology 2021;9:733831
Frontiers in cell and developmental biology 2021;9:733831
Mesenchymal Stem Cells With Cancer-Associated Fibroblast-Like Phenotype Stimulate SDF-1/CXCR4 Axis to Enhance the Growth and Invasion of B-Cell Acute Lymphoblastic Leukemia Cells Through Cell-to-Cell Communication.
Pan C, Fang Q, Liu P, Ma D, Cao S, Zhang L, Chen Q, Hu T, Wang J
Frontiers in cell and developmental biology 2021;9:708513
Frontiers in cell and developmental biology 2021;9:708513
Mechanically Activated Calcium Channel PIEZO1 Modulates Radiation-Induced Epithelial-Mesenchymal Transition by Forming a Positive Feedback With TGF-β1.
Huang JQ, Zhang H, Guo XW, Lu Y, Wang SN, Cheng B, Dong SH, Lyu XL, Li FS, Li YW
Frontiers in molecular biosciences 2021;8:725275
Frontiers in molecular biosciences 2021;8:725275
Tubular cell-derived exosomal miR-150-5p contributes to renal fibrosis following unilateral ischemia-reperfusion injury by activating fibroblast in vitro and in vivo.
Zhou X, Zhao S, Li W, Ruan Y, Yuan R, Ning J, Jiang K, Xie J, Yao X, Li H, Li C, Rao T, Yu W, Cheng F
International journal of biological sciences 2021;17(14):4021-4033
International journal of biological sciences 2021;17(14):4021-4033
NEDD4L-induced β-catenin ubiquitination suppresses the formation and progression of interstitial pulmonary fibrosis via inhibiting the CTHRC1/HIF-1α axis.
Chen L, Yang Y, Yan H, Peng X, Zou J
International journal of biological sciences 2021;17(13):3320-3330
International journal of biological sciences 2021;17(13):3320-3330
Sympathetic Denervation Ameliorates Renal Fibrosis via Inhibition of Cellular Senescence.
Li Q, Deng Y, Liu L, Zhang C, Cai Y, Zhang T, Han M, Xu G
Frontiers in immunology 2021;12:823935
Frontiers in immunology 2021;12:823935
Ferulic Acid Ameliorates Hepatic Inflammation and Fibrotic Liver Injury by Inhibiting PTP1B Activity and Subsequent Promoting AMPK Phosphorylation.
Wu J, Xue X, Fan G, Gu Y, Zhou F, Zheng Q, Liu R, Li Y, Ma B, Li S, Huang G, Ma L, Li X
Frontiers in pharmacology 2021;12:754976
Frontiers in pharmacology 2021;12:754976
The Extracellular Matrix Enriched With Exosomes for the Treatment on Pulmonary Fibrosis in Mice.
Yu Y, Liu X, Zhao Z, Xu Z, Qiao Y, Zhou Y, Qiao H, Zhong J, Dai J, Suo G
Frontiers in pharmacology 2021;12:747223
Frontiers in pharmacology 2021;12:747223
Transcriptome-Based Network Analysis Reveals Hirudin Potentiates Anti-Renal Fibrosis Efficacy in UUO Rats.
Yu HX, Lin W, Yang K, Wei LJ, Chen JL, Liu XY, Zhong K, Chen X, Pei M, Yang HT
Frontiers in pharmacology 2021;12:741801
Frontiers in pharmacology 2021;12:741801
Berberine Reduces Lipid Accumulation by Promoting Fatty Acid Oxidation in Renal Tubular Epithelial Cells of the Diabetic Kidney.
Rong Q, Han B, Li Y, Yin H, Li J, Hou Y
Frontiers in pharmacology 2021;12:729384
Frontiers in pharmacology 2021;12:729384
Mefunidone Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Mice.
Han Y, Jiang M, He R, Lv X, Liao X, He Y, Zhang F, Long L, Jiang G, Peng Z, Tao L, Hu G, Meng J
Frontiers in pharmacology 2021;12:713572
Frontiers in pharmacology 2021;12:713572
Binding of Plasminogen to Streptococcus suis Protein Endopeptidase O Facilitates Evasion of Innate Immunity in Streptococcus suis.
Zhou Y, Yan K, Sun C, Liu F, Peng W, Chen H, Yuan F, Bei W, Li J
Frontiers in microbiology 2021;12:694103
Frontiers in microbiology 2021;12:694103
ShenLian Extract Enhances TGF-β Functions in the Macrophage-SMC Unit and Stabilizes Atherosclerotic Plaques.
Liu L, Li Q, Yin J, Zhao Z, Sun L, Ran Q, Du X, Wang Y, Li Y, Yang Q, Chen Y, Weng X, Cai W, Zhu X
Frontiers in pharmacology 2021;12:669730
Frontiers in pharmacology 2021;12:669730
Ameliorative Effects of Osthole on Experimental Renal Fibrosis in vivo and in vitro by Inhibiting IL-11/ERK1/2 Signaling.
Wu F, Zhao Y, Shao Q, Fang K, Dong R, Jiang S, Lu F, Luo J, Chen G
Frontiers in pharmacology 2021;12:646331
Frontiers in pharmacology 2021;12:646331
Exosomal miR-500a-5p derived from cancer-associated fibroblasts promotes breast cancer cell proliferation and metastasis through targeting USP28.
Chen B, Sang Y, Song X, Zhang D, Wang L, Zhao W, Liang Y, Zhang N, Yang Q
Theranostics 2021;11(8):3932-3947
Theranostics 2021;11(8):3932-3947
Exosomal miR-21 from tubular cells contributes to renal fibrosis by activating fibroblasts via targeting PTEN in obstructed kidneys.
Zhao S, Li W, Yu W, Rao T, Li H, Ruan Y, Yuan R, Li C, Ning J, Li S, Chen W, Cheng F, Zhou X
Theranostics 2021;11(18):8660-8673
Theranostics 2021;11(18):8660-8673
Local administration of liposomal-based Srpx2 gene therapy reverses pulmonary fibrosis by blockading fibroblast-to-myofibroblast transition.
Wang Q, Liu J, Hu Y, Pan T, Xu Y, Yu J, Xiong W, Zhou Q, Wang Y
Theranostics 2021;11(14):7110-7125
Theranostics 2021;11(14):7110-7125
The NEAT1_2/miR-491 Axis Modulates Papillary Thyroid Cancer Invasion and Metastasis Through TGM2/NFκb/FN1 Signaling.
Sun W, Qin Y, Wang Z, Dong W, He L, Zhang T, Zhang H
Frontiers in oncology 2021;11:610547
Frontiers in oncology 2021;11:610547
miR-23a-3p regulates the inflammatory response and fibrosis in diabetic kidney disease by targeting early growth response 1.
Sheng S, Zou M, Yang Y, Guan M, Ren S, Wang X, Wang L, Xue Y
In vitro cellular & developmental biology. Animal 2021 Sep;57(8):763-774
In vitro cellular & developmental biology. Animal 2021 Sep;57(8):763-774
Use of Platelet-Rich Plasma Plus Suramin, an Antifibrotic Agent, to Improve Muscle Healing After Injuries.
Tsai WC, Yu TY, Chang GJ, Chang HN, Lin LP, Lin MS, Pang JS
The American journal of sports medicine 2021 Sep;49(11):3102-3112
The American journal of sports medicine 2021 Sep;49(11):3102-3112
Exercise training ameliorates early diabetic kidney injury by regulating the H(2) S/SIRT1/p53 pathway.
Yang L, Li DX, Cao BQ, Liu SJ, Xu DH, Zhu XY, Liu YJ
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Sep;35(9):e21823
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Sep;35(9):e21823
Presegetane diterpenoids from Euphorbia sieboldiana as a new type of anti-liver fibrosis agents that inhibit TGF-β/Smad signaling pathway.
Li S, Gan L, Tian YJ, Tian Y, Fan RZ, Huang D, Yuan FY, Zhang X, Lin Y, Zhu QF, Tang GH, Yan XL, Yin S
Bioorganic chemistry 2021 Sep;114:105222
Bioorganic chemistry 2021 Sep;114:105222
MiR-192-5p inhibits proliferation, migration, and invasion in papillary thyroid carcinoma cells by regulation of SH3RF3.
Fu S, Ma C, Tang X, Ma X, Jing G, Zhao N, Ran J
Bioscience reports 2021 Sep 30;41(9)
Bioscience reports 2021 Sep 30;41(9)
KLF15 negatively regulates cardiac fibrosis by which SDF-1β attenuates cardiac fibrosis in type 2 diabetic mice.
Tian Y, Wang Z, Zheng X, Song W, Cai L, Rane M, Zhao Y
Toxicology and applied pharmacology 2021 Sep 15;427:115654
Toxicology and applied pharmacology 2021 Sep 15;427:115654
MIER3 induces epithelial-mesenchymal transition and promotes breast cancer cell aggressiveness via forming a co-repressor complex with HDAC1/HDAC2/Snail.
Huang W, Chen J, Liu X, Liu X, Duan S, Chen L, Liu X, Lan J, Zou Y, Guo D, Zhou J
Experimental cell research 2021 Sep 1;406(1):112722
Experimental cell research 2021 Sep 1;406(1):112722
A novel in vitro assay for peripheral nerve-related cell migration that preserves both extracellular matrix-derived molecular cues and nanofiber-derived topography.
Achenbach P, Hambeukers I, Pierling AL, Gerardo-Nava JL, Hillerbrand L, Sechi AS, Glücks KJ, Dalton PD, Pich A, Dievernich A, Altinova H, Brook GA
Journal of neuroscience methods 2021 Sep 1;361:109289
Journal of neuroscience methods 2021 Sep 1;361:109289
Interleukin-7 Is Associated with Clinical and Pathological Activities in Immunoglobulin A Nephropathy and Protects the Renal Proximal Tubule Epithelium from Cellular Fibrosis.
Deng YJ, Lin XP, Li XQ, Lu PF, Cai Y, Liu LL, Pei GC, Han M
Current medical science 2021 Oct;41(5):880-887
Current medical science 2021 Oct;41(5):880-887
The long non-coding RNA PFI protects against pulmonary fibrosis by interacting with splicing regulator SRSF1.
Sun J, Jin T, Su W, Guo Y, Niu Z, Guo J, Li L, Wang J, Ma L, Yu T, Li X, Zhou Y, Shan H, Liang H
Cell death and differentiation 2021 Oct;28(10):2916-2930
Cell death and differentiation 2021 Oct;28(10):2916-2930
Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors.
Xia W, Xie J, Cai Z, Liu X, Wen J, Cui ZK, Zhao R, Zhou X, Chen J, Mao X, Gu Z, Zou Z, Zou Z, Zhang Y, Zhao M, Mac M, Song Q, Bai X
Nature communications 2021 Oct 15;12(1):6043
Nature communications 2021 Oct 15;12(1):6043
Triiodothyronine ameliorates silica-induced pulmonary inflammation and fibrosis in mice.
Yang M, Wang D, Gan S, Wang B, Yu L, Xie Y, Fan L, Ma J, Chen W
The Science of the total environment 2021 Oct 10;790:148041
The Science of the total environment 2021 Oct 10;790:148041
Maiwei Yangfei decoction prevents bleomycin-induced pulmonary fibrosis in mice.
Xu Y, Peng W, Han D, Feng F, Wang Z, Gu C, Zhou X, Wu Q
Experimental and therapeutic medicine 2021 Nov;22(5):1306
Experimental and therapeutic medicine 2021 Nov;22(5):1306
Injectable self-assembling peptide nanofiber hydrogel as a bioactive 3D platform to promote chronic wound tissue regeneration.
Lou P, Liu S, Wang Y, Pan C, Xu X, Zhao M, Liao G, Yang G, Yuan Y, Li L, Zhang J, Chen Y, Cheng J, Lu Y, Liu J
Acta biomaterialia 2021 Nov;135:100-112
Acta biomaterialia 2021 Nov;135:100-112
Si-Wu-Tang ameliorates fibrotic liver injury via modulating intestinal microbiota and bile acid homeostasis.
Xue X, Wu J, Ding M, Gao F, Zhou F, Xu B, Lu M, Li J, Li X
Chinese medicine 2021 Nov 4;16(1):112
Chinese medicine 2021 Nov 4;16(1):112
Drug-containing serum of rhubarb-astragalus capsule inhibits the epithelial-mesenchymal transformation of HK-2 by downregulating TGF-β1/p38MAPK/Smad2/3 pathway.
Qin MY, Huang SQ, Zou XQ, Zhong XB, Yang YF, Zhang YT, Mi ZC, Zhang YS, Huang ZG
Journal of ethnopharmacology 2021 Nov 15;280:114414
Journal of ethnopharmacology 2021 Nov 15;280:114414
MPP7 promotes the migration and invasion of breast cancer cells via EGFR/AKT signaling.
Liao W, Fan L, Li M, Deng H, Yang A, Liu F
Cell biology international 2021 May;45(5):948-956
Cell biology international 2021 May;45(5):948-956
Fibronectin-integrin signaling regulates PLVAP localization at endothelial fenestrae by microtubule stabilization.
Nakakura T, Suzuki T, Horiguchi K, Tanaka H, Arisawa K, Miyashita T, Nekooki-Machida Y, Hagiwara H
Cell and tissue research 2021 May;384(2):449-463
Cell and tissue research 2021 May;384(2):449-463
miR-509-3p Suppresses Migration, Invasion, and Epithelial- Mesenchymal Transition in Melanoma Cells by Targeting Collagen Triple Helix Repeat Containing 1.
Yuan K, Sun Y, Ji Y
Balkan medical journal 2021 May;38(3):177-182
Balkan medical journal 2021 May;38(3):177-182
Improved response of human gingival fibroblasts to titanium coated with micro-/nano-structured tantalum.
Zhang CN, Zhou LY, Qian SJ, Gu YX, Shi JY, Lai HC
International journal of implant dentistry 2021 May 3;7(1):36
International journal of implant dentistry 2021 May 3;7(1):36
A HIF1A/miR-485-5p/SRPK1 axis modulates the aggressiveness of glioma cells upon hypoxia.
Cheng L, Peng R, Guo P, Zhang H, Liu D, Liao X, Liu Y, Mo X, Liao Y
Experimental cell research 2021 May 1;402(1):112547
Experimental cell research 2021 May 1;402(1):112547
Glucagon-like peptide-1 (GLP-1) improved diabetic lung fibrosis via AMPK and microRNA-27a (miR-27a).
Liu J, Li X, Lu S, Zheng X, Zhang X, Zhao W
Annals of translational medicine 2021 Mar;9(6):492
Annals of translational medicine 2021 Mar;9(6):492
Dopamine receptor D2 inhibition alleviates diabetic hepatic stellate cells fibrosis by regulating the TGF-β1/Smads and NFκB pathways.
Zhao B, Li S, Guo Z, Chen Z, Zhang X, Xu C, Chen J, Wei C
Clinical and experimental pharmacology & physiology 2021 Mar;48(3):370-380
Clinical and experimental pharmacology & physiology 2021 Mar;48(3):370-380
miR‑106b‑5p targeting SIX1 inhibits TGF‑β1‑induced pulmonary fibrosis and epithelial‑mesenchymal transition in asthma through regulation of E2F1.
Liu S, Chen X, Zhang S, Wang X, Du X, Chen J, Zhou G
International journal of molecular medicine 2021 Mar;47(3)
International journal of molecular medicine 2021 Mar;47(3)
KLF4 initiates sustained YAP activation to promote renal fibrosis in mice after ischemia-reperfusion kidney injury.
Xu D, Chen PP, Zheng PQ, Yin F, Cheng Q, Zhou ZL, Xie HY, Li JY, Ni JY, Wang YZ, Chen SJ, Zhou L, Wang XX, Liu J, Zhang W, Lu LM
Acta pharmacologica Sinica 2021 Mar;42(3):436-450
Acta pharmacologica Sinica 2021 Mar;42(3):436-450
Aptamer-SH2 superbinder-based targeted therapy for pancreatic ductal adenocarcinoma.
Liu AD, Zhou J, Bi XY, Hou GQ, Li SS, Chen Q, Xu H, Cao X
Clinical and translational medicine 2021 Mar;11(3):e337
Clinical and translational medicine 2021 Mar;11(3):e337
pH-Sensitive Nanoparticles Composed Solely of Membrane-Disruptive Macromolecules for Treating Pancreatic Cancer.
Fan F, Jin L, Yang L
ACS applied materials & interfaces 2021 Mar 24;13(11):12824-12835
ACS applied materials & interfaces 2021 Mar 24;13(11):12824-12835
The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity.
Chen S, Liu X, Peng C, Tan C, Sun H, Liu H, Zhang Y, Wu P, Cui C, Liu C, Yang D, Li Z, Lu J, Guan J, Ke X, Wang R, Bo X, Xu X, Han J, Liu J
Cell metabolism 2021 Mar 2;33(3):565-580.e7
Cell metabolism 2021 Mar 2;33(3):565-580.e7
Identification and functional analysis of senescence-associated secretory phenotype of premature senescent hepatocytes induced by hexavalent chromium.
Ma Y, Liang Y, Liang N, Zhang Y, Xiao F
Ecotoxicology and environmental safety 2021 Mar 15;211:111908
Ecotoxicology and environmental safety 2021 Mar 15;211:111908
Regulation of connective tissue growth factor expression by miR-133b for the treatment of renal interstitial fibrosis in aged mice with unilateral ureteral obstruction.
Cao D, Wang Y, Zhang Y, Zhang Y, Huang Q, Yin Z, Cai G, Chen X, Sun X
Stem cell research & therapy 2021 Mar 10;12(1):171
Stem cell research & therapy 2021 Mar 10;12(1):171
Inhibition of ER stress by targeting the IRE1α-TXNDC5 pathway alleviates crystalline silica-induced pulmonary fibrosis.
Chen X, Li C, Liu J, He Y, Wei Y, Chen J
International immunopharmacology 2021 Jun;95:107519
International immunopharmacology 2021 Jun;95:107519
USP9X deubiquitinates connexin43 to prevent high glucose-induced epithelial-to-mesenchymal transition in NRK-52E cells.
Sun XH, Xiao HM, Zhang M, Lin ZY, Yang Y, Chen R, Liu PQ, Huang KP, Huang HQ
Biochemical pharmacology 2021 Jun;188:114562
Biochemical pharmacology 2021 Jun;188:114562
STAT3/HIF-1α signaling activation mediates peritoneal fibrosis induced by high glucose.
Yang X, Bao M, Fang Y, Yu X, Ji J, Ding X
Journal of translational medicine 2021 Jun 30;19(1):283
Journal of translational medicine 2021 Jun 30;19(1):283
Mesenchymal stem cells ameliorate silica-induced pulmonary fibrosis by inhibition of inflammation and epithelial-mesenchymal transition.
Wei J, Zhao Q, Yang G, Huang R, Li C, Qi Y, Hao C, Yao W
Journal of cellular and molecular medicine 2021 Jun 2;25(13):6417-28
Journal of cellular and molecular medicine 2021 Jun 2;25(13):6417-28
A Novel Rat Model with Long Range Optic Nerve Injury to Study Retinal Ganglion Cells Endogenous Regeneration.
Zhang S, Liu B, Zhu H, Jin H, Gong Z, Qiu H, Xu M, Chen M, Nan K, Wu W
Neuroscience 2021 Jun 15;465:71-84
Neuroscience 2021 Jun 15;465:71-84
LncRNA CTD-2528L19.6 prevents the progression of IPF by alleviating fibroblast activation.
Chen T, Guo Y, Wang J, Ai L, Ma L, He W, Li Z, Yu X, Li J, Fan X, Gu Y, Liang H
Cell death & disease 2021 Jun 10;12(6):600
Cell death & disease 2021 Jun 10;12(6):600
Pterostilbene alleviates pulmonary fibrosis by regulating ASIC2.
Peng Y, Zhang Y, Zhang Y, Wang X, Xia Y
Chinese medicine 2021 Jul 28;16(1):66
Chinese medicine 2021 Jul 28;16(1):66
GALNT2 promotes cell proliferation, migration, and invasion by activating the Notch/Hes1-PTEN-PI3K/Akt signaling pathway in lung adenocarcinoma.
Wang W, Sun R, Zeng L, Chen Y, Zhang N, Cao S, Deng S, Meng X, Yang S
Life sciences 2021 Jul 1;276:119439
Life sciences 2021 Jul 1;276:119439
Physcion 8-O-β-glucopyranoside ameliorates liver fibrosis through inflammation inhibition by regulating SIRT3-mediated NF-κB P65 nuclear expression.
Chen C, Gu J, Wang J, Wu Y, Yang A, Chen T, Zhou T, Liu Z
International immunopharmacology 2021 Jan;90:107206
International immunopharmacology 2021 Jan;90:107206
Long noncoding RNA EPB41L4A-AS1 functions as an oncogene by regulating the Rho/ROCK pathway in colorectal cancer.
Bin J, Nie S, Tang Z, Kang A, Fu Z, Hu Y, Liao Q, Xiong W, Zhou Y, Tang Y, Jiang J
Journal of cellular physiology 2021 Jan;236(1):523-535
Journal of cellular physiology 2021 Jan;236(1):523-535
Treatment of keloids through Runx2 siRNA‑induced inhibition of the PI3K/AKT signaling pathway.
Lv W, Wu M, Ren Y, Luo X, Hu W, Zhang Q, Wu Y
Molecular medicine reports 2021 Jan;23(1)
Molecular medicine reports 2021 Jan;23(1)
Mitomycin C induces pulmonary vascular endothelial-to-mesenchymal transition and pulmonary veno-occlusive disease via Smad3-dependent pathway in rats.
Zhang C, Lu W, Luo X, Liu S, Li Y, Zheng Q, Liu W, Wu X, Chen Y, Jiang Q, Zhang Z, Gu G, Chen J, Chen H, Liao J, Liu C, Hong C, Tang H, Sun D, Yang K, Wang J
British journal of pharmacology 2021 Jan;178(1):217-235
British journal of pharmacology 2021 Jan;178(1):217-235
Responsive and activable nanomedicines for remodeling the tumor microenvironment.
Zhang Y, Han X, Nie G
Nature protocols 2021 Jan;16(1):405-430
Nature protocols 2021 Jan;16(1):405-430
Anti-renal interstitial fibrosis effect of norcantharidin is exerted through inhibition of PP2Ac-mediated C-terminal phosphorylation of Smad3.
Luo HW, Yin DD, Xiao Z, Wen L, Liao YJ, Tang CY, Zeng D, Xiao HT, Li Y
Chemical biology & drug design 2021 Feb;97(2):293-304
Chemical biology & drug design 2021 Feb;97(2):293-304
Involvement of miR-27a-3p in diabetic nephropathy via affecting renal fibrosis, mitochondrial dysfunction, and endoplasmic reticulum stress.
Wu L, Wang Q, Guo F, Ma X, Wang J, Zhao Y, Yan Y, Qin G
Journal of cellular physiology 2021 Feb;236(2):1454-1468
Journal of cellular physiology 2021 Feb;236(2):1454-1468
Epigallocatechin gallate (EGCG) attenuates myocardial hypertrophy and fibrosis induced by transverse aortic constriction via inhibiting the Akt/mTOR pathway.
Cui Y, Wang Y, Liu G
Pharmaceutical biology 2021 Dec;59(1):1305-1313
Pharmaceutical biology 2021 Dec;59(1):1305-1313
Exosomal ANXA2 derived from ovarian cancer cells regulates epithelial-mesenchymal plasticity of human peritoneal mesothelial cells.
Gao L, Nie X, Gou R, Hu Y, Dong H, Li X, Lin B
Journal of cellular and molecular medicine 2021 Dec;25(23):10916-10929
Journal of cellular and molecular medicine 2021 Dec;25(23):10916-10929
Tissue factor potentiates adherence of breast cancer cells to human umbilical vein endothelial cells under static and flow conditions.
Jin Y, Liu W, Wang F, Wang M, Xu K, Yang A, Wang C, Zhang L, Zhang F, Li M
Cell adhesion & migration 2021 Dec;15(1):74-83
Cell adhesion & migration 2021 Dec;15(1):74-83
Withaferin A protects against hyperuricemia induced kidney injury and its possible mechanisms.
Zhao X, Wang J, Tang L, Li P, Ru J, Bai Y
Bioengineered 2021 Dec;12(1):589-600
Bioengineered 2021 Dec;12(1):589-600
Deficiency of CARMA3 attenuates the development of bleomycin induced pulmonary fibrosis.
Wu Y, Qi Y, Qiu Z, Chen W
Biochemical and biophysical research communications 2021 Dec 3;581:81-88
Biochemical and biophysical research communications 2021 Dec 3;581:81-88
Effects of L-leucine on the properties of spray-dried swellable microparticles with wrinkled surfaces for inhalation therapy of pulmonary fibrosis.
Wang X, Wan W, Lu J, Quan G, Pan X, Liu P
International journal of pharmaceutics 2021 Dec 15;610:121223
International journal of pharmaceutics 2021 Dec 15;610:121223
Heat shock protein 90 inhibitor ameliorates pancreatic fibrosis by degradation of transforming growth factor-β receptor.
Peng YF, Lin H, Liu DC, Zhu XY, Huang N, Wei YX, Li L
Cellular signalling 2021 Aug;84:110001
Cellular signalling 2021 Aug;84:110001
LncRNA-MALAT1/miRNA-204-5p/Smad4 Axis Regulates Epithelial-Mesenchymal Transition, Proliferation and Migration of Lens Epithelial Cells.
Peng C, Wang Y, Ji L, Kuang L, Yu Z, Li H, Zhang J, Zhao J
Current eye research 2021 Aug;46(8):1137-1147
Current eye research 2021 Aug;46(8):1137-1147
IL-1β augments TGF-β inducing epithelial-mesenchymal transition of epithelial cells and associates with poor pulmonary function improvement in neutrophilic asthmatics.
Zhang S, Fan Y, Qin L, Fang X, Zhang C, Yue J, Bai W, Wang G, Chen Z, Renz H, Skevaki C, Liu X, Xie M
Respiratory research 2021 Aug 3;22(1):216
Respiratory research 2021 Aug 3;22(1):216
Adenosine A3 receptor activated in H(2)O(2) oxidative stress of primary open-angle glaucoma.
Zhou Z, Gao Z, Yan W, Zhang Y, Huang J, Xiong K
Annals of translational medicine 2021 Apr;9(7):526
Annals of translational medicine 2021 Apr;9(7):526
Metformin attenuates post-epidural fibrosis by inhibiting the TGF-β1/Smad3 and HMGB1/TLR4 signaling pathways.
Song Z, Wu T, Sun J, Wang H, Hua F, Nicolas YSM, Kc R, Chen K, Jin Z, Liu J, Zhang M
Journal of cellular and molecular medicine 2021 Apr;25(7):3272-3283
Journal of cellular and molecular medicine 2021 Apr;25(7):3272-3283
Astragalus membranaceus and Salvia miltiorrhiza ameliorates cyclosporin A-induced chronic nephrotoxicity through the "gut-kidney axis".
Han C, Jiang YH, Li W, Liu Y
Journal of ethnopharmacology 2021 Apr 6;269:113768
Journal of ethnopharmacology 2021 Apr 6;269:113768
Metformin effectively treats Tsc1 deletion-caused kidney pathology by upregulating AMPK phosphorylation.
Fang Y, Li F, Qi C, Mao X, Wang F, Zhao Z, Chen JK, Zhang Z, Wu H
Cell death discovery 2020;6:52
Cell death discovery 2020;6:52
IL-33-induced neutrophil extracellular traps degrade fibronectin in a murine model of bronchopulmonary dysplasia.
Jin R, Xu J, Gao Q, Mao X, Yin J, Lu K, Guo Y, Zhang M, Cheng R
Cell death discovery 2020;6:33
Cell death discovery 2020;6:33
Transcriptomic Analysis Reveals the Protection of Astragaloside IV against Diabetic Nephropathy by Modulating Inflammation.
Zhang Y, Tao C, Xuan C, Jiang J, Cao W
Oxidative medicine and cellular longevity 2020;2020:9542165
Oxidative medicine and cellular longevity 2020;2020:9542165
Hirudin Ameliorates Renal Interstitial Fibrosis via Regulating TGF-β1/Smad and NF-κB Signaling in UUO Rat Model.
Yang K, Fan B, Zhao Q, Ji Y, Liu P, Gao S, Ren T, Dou Y, Pei M, Yang H
Evidence-based complementary and alternative medicine : eCAM 2020;2020:7291075
Evidence-based complementary and alternative medicine : eCAM 2020;2020:7291075
Withaferin A Exerts Preventive Effect on Liver Fibrosis through Oxidative Stress Inhibition in a Sirtuin 3-Dependent Manner.
Gu J, Chen C, Wang J, Chen T, Yao W, Yan T, Liu Z
Oxidative medicine and cellular longevity 2020;2020:2452848
Oxidative medicine and cellular longevity 2020;2020:2452848
Empagliflozin Protects Against Proximal Renal Tubular Cell Injury Induced by High Glucose via Regulation of Hypoxia-Inducible Factor 1-Alpha.
Ndibalema AR, Kabuye D, Wen S, Li L, Li X, Fan Q
Diabetes, metabolic syndrome and obesity : targets and therapy 2020;13:1953-1967
Diabetes, metabolic syndrome and obesity : targets and therapy 2020;13:1953-1967
Melatonin ameliorates hyperglycaemia-induced renal inflammation by inhibiting the activation of TLR4 and TGF-β1/Smad3 signalling pathway.
Wei J, Wang Y, Qi X, Fan Z, Wu Y
American journal of translational research 2020;12(5):1584-1599
American journal of translational research 2020;12(5):1584-1599
Hyperoside Attenuates Bleomycin-Induced Pulmonary Fibrosis Development in Mice.
Huang J, Tong X, Zhang L, Zhang Y, Wang L, Wang D, Zhang S, Fan H
Frontiers in pharmacology 2020;11:550955
Frontiers in pharmacology 2020;11:550955
Scutellarein inhibits BLM-mediated pulmonary fibrosis by affecting fibroblast differentiation, proliferation, and apoptosis.
Miao K, Pan T, Mou Y, Zhang L, Xiong W, Xu Y, Yu J, Wang Y
Therapeutic advances in chronic disease 2020;11:2040622320940185
Therapeutic advances in chronic disease 2020;11:2040622320940185
Epithelial-Mesenchymal Transition in Asthma Airway Remodeling Is Regulated by the IL-33/CD146 Axis.
Sun Z, Ji N, Ma Q, Zhu R, Chen Z, Wang Z, Qian Y, Wu C, Hu F, Huang M, Zhang M
Frontiers in immunology 2020;11:1598
Frontiers in immunology 2020;11:1598
Andrographolide attenuates epithelial-mesenchymal transition induced by TGF-β1 in alveolar epithelial cells.
Li J, Liu J, Yue W, Xu K, Cai W, Cui F, Li Z, Wang W, He J
Journal of cellular and molecular medicine 2020 Sep;24(18):10501-10511
Journal of cellular and molecular medicine 2020 Sep;24(18):10501-10511
Deubiquitinase USP13 promotes extracellular matrix expression by stabilizing Smad4 in lung fibroblast cells.
Liao X, Li Y, Liu J, Zhang Y, Tan J, Kass DJ, Rojas M, Mallampalli RK, Zhao J, Zhao Y
Translational research : the journal of laboratory and clinical medicine 2020 Sep;223:15-24
Translational research : the journal of laboratory and clinical medicine 2020 Sep;223:15-24
High-mobility group box 1 promotes epithelial-to-mesenchymal transition in crystalline silica induced pulmonary inflammation and fibrosis.
Ma J, Xu Y, Li W, Zhou Y, Wang D, Yang M, Wang B, Chen W
Toxicology letters 2020 Sep 15;330:134-143
Toxicology letters 2020 Sep 15;330:134-143
The AKT/GSK3-Mediated Slug Expression Contributes to Oxaliplatin Resistance in Colorectal Cancer via Upregulation of ERCC1.
Wei W, Ma XD, Jiang GM, Shi B, Zhong W, Sun CL, Zhao L, Hou YJ, Wang H
Oncology research 2020 Sep 1;28(4):423-438
Oncology research 2020 Sep 1;28(4):423-438
Deubiquitinase USP29 promotes gastric cancer cell migration by cooperating with phosphatase SCP1 to stabilize Snail protein.
Qian W, Li Q, Wu X, Li W, Li Q, Zhang J, Li M, Zhang D, Zhao H, Zou X, Jia H, Zhang L, Yang XD, Hou Z
Oncogene 2020 Oct;39(44):6802-6815
Oncogene 2020 Oct;39(44):6802-6815
Neutrophil extracellular traps promote scar formation in post-epidural fibrosis.
Jin Z, Sun J, Song Z, Chen K, Nicolas YSM, Kc R, Ma Q, Liu J, Zhang M
NPJ Regenerative medicine 2020 Oct 30;5(1):19
NPJ Regenerative medicine 2020 Oct 30;5(1):19
MAD2B contributes to parietal epithelial cell activation and crescentic glomerulonephritis via Skp2.
Ye C, Xiong W, Lei CT, Tang H, Su H, Yi F, Zhang C
American journal of physiology. Renal physiology 2020 Oct 1;319(4):F636-F646
American journal of physiology. Renal physiology 2020 Oct 1;319(4):F636-F646
MiR-185-5p ameliorates endoplasmic reticulum stress and renal fibrosis by downregulation of ATF6.
Yuan Q, Xu T, Chen Y, Qu W, Sun D, Liu X, Sun L
Laboratory investigation; a journal of technical methods and pathology 2020 Nov;100(11):1436-1446
Laboratory investigation; a journal of technical methods and pathology 2020 Nov;100(11):1436-1446
Sox13 promotes hepatocellular carcinoma metastasis by transcriptionally activating Twist1.
Feng M, Fang F, Fang T, Jiao H, You S, Wang X, Zhao W
Laboratory investigation; a journal of technical methods and pathology 2020 Nov;100(11):1400-1410
Laboratory investigation; a journal of technical methods and pathology 2020 Nov;100(11):1400-1410
TREM2 Alzheimer's variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages.
Hall-Roberts H, Agarwal D, Obst J, Smith TB, Monzón-Sandoval J, Di Daniel E, Webber C, James WS, Mead E, Davis JB, Cowley SA
Alzheimer's research & therapy 2020 Nov 16;12(1):151
Alzheimer's research & therapy 2020 Nov 16;12(1):151
Norcantharidin protects against renal interstitial fibrosis by suppressing TWEAK-mediated Smad3 phosphorylation.
Zeng D, Xiao Z, Xu Q, Luo H, Wen L, Tang C, Shan Y, Tian J, Wei J, Li Y
Life sciences 2020 Nov 1;260:118488
Life sciences 2020 Nov 1;260:118488
Ganoderic acid hinders renal fibrosis via suppressing the TGF-β/Smad and MAPK signaling pathways.
Geng XQ, Ma A, He JZ, Wang L, Jia YL, Shao GY, Li M, Zhou H, Lin SQ, Ran JH, Yang BX
Acta pharmacologica Sinica 2020 May;41(5):670-677
Acta pharmacologica Sinica 2020 May;41(5):670-677
Inhibition of miR-182-5p attenuates pulmonary fibrosis via TGF-β/Smad pathway.
Chen Y, Zhang Q, Zhou Y, Yang Z, Tan M
Human & experimental toxicology 2020 May;39(5):683-695
Human & experimental toxicology 2020 May;39(5):683-695
Ischemia-reperfusion injury of brain induces endothelial-mesenchymal transition and vascular fibrosis via activating let-7i/TGF-βR1 double-negative feedback loop.
Chen D, Li L, Wang Y, Xu R, Peng S, Zhou L, Deng Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 May;34(5):7178-7191
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 May;34(5):7178-7191
Cardamonin retards progression of autosomal dominant polycystic kidney disease via inhibiting renal cyst growth and interstitial fibrosis.
He J, Zhou H, Meng J, Zhang S, Li X, Wang S, Shao G, Jin W, Geng X, Zhu S, Yang B
Pharmacological research 2020 May;155:104751
Pharmacological research 2020 May;155:104751
Renoprotective Effect of a Dipeptidyl Peptidase-4 Inhibitor on Aging Mice.
Ban TH, Kim EN, Kim MY, Lim JH, Lee JH, Kim HD, Yoon HE, Park CW, Choi BS
Aging and disease 2020 May;11(3):588-602
Aging and disease 2020 May;11(3):588-602
IRF-1 promotes renal fibrosis by downregulation of Klotho.
Li Y, Liu Y, Huang Y, Yang K, Xiao T, Xiong J, Wang K, Liu C, He T, Yu Y, Han W, Wang Y, Bi X, Zhang J, Huang Y, Zhang B, Zhao J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Mar;34(3):4415-4429
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Mar;34(3):4415-4429
WNT1-inducible signaling protein-1 mediates TGF-β1-induced renal fibrosis in tubular epithelial cells and unilateral ureteral obstruction mouse models via autophagy.
Yang X, Wang H, Tu Y, Li Y, Zou Y, Li G, Wang L, Zhong X
Journal of cellular physiology 2020 Mar;235(3):2009-2022
Journal of cellular physiology 2020 Mar;235(3):2009-2022
Olfactory ensheathing cells facilitate neurite sprouting and outgrowth by secreting high levels of hevin.
Ge L, Zhuo Y, Wu P, Liu Y, Qi L, Teng X, Duan D, Chen P, Lu M
Journal of chemical neuroanatomy 2020 Mar;104:101728
Journal of chemical neuroanatomy 2020 Mar;104:101728
A PTAL-miR-101-FN1 Axis Promotes EMT and Invasion-Metastasis in Serous Ovarian Cancer.
Liang H, Yu M, Yang R, Zhang L, Zhang L, Zhu D, Luo H, Hong Y, Yu T, Sun J, Shan H, Gu Y
Molecular therapy oncolytics 2020 Mar 27;16:53-62
Molecular therapy oncolytics 2020 Mar 27;16:53-62
Tartrate-Resistant Acid Phosphatase 5/ACP5 Interacts with p53 to Control the Expression of SMAD3 in Lung Adenocarcinoma.
Hu Y, Yu J, Wang Q, Zhang L, Chen X, Cao Y, Zhao J, Xu Y, Jiang D, Wang Y, Xiong W
Molecular therapy oncolytics 2020 Mar 27;16:272-288
Molecular therapy oncolytics 2020 Mar 27;16:272-288
Monocyte-derived alveolar macrophage apolipoprotein E participates in pulmonary fibrosis resolution.
Cui H, Jiang D, Banerjee S, Xie N, Kulkarni T, Liu RM, Duncan SR, Liu G
JCI insight 2020 Mar 12;5(5)
JCI insight 2020 Mar 12;5(5)
Antisense Oligonucleotide in LNA-Gapmer Design Targeting TGFBR2-A Key Single Gene Target for Safe and Effective Inhibition of TGFβ Signaling.
Kuespert S, Heydn R, Peters S, Wirkert E, Meyer AL, Siebörger M, Johannesen S, Aigner L, Bogdahn U, Bruun TH
International journal of molecular sciences 2020 Mar 12;21(6)
International journal of molecular sciences 2020 Mar 12;21(6)
Long non-coding RNA DBH-AS1 promotes cancer progression in diffuse large B-cell lymphoma by targeting FN1 via RNA-binding protein BUD13.
Song Y, Gao F, Peng Y, Yang X
Cell biology international 2020 Jun;44(6):1331-1340
Cell biology international 2020 Jun;44(6):1331-1340
HMGB1 protein promotes glomerular mesangial matrix deposition via TLR2 in lupus nephritis.
Feng X, Yang R, Tian Y, Miao X, Guo H, Gao F, Yang L, Zhao S, Zhang W, Liu J, Li H, Tian Y, Zhao L, Wang S, Liu W, Wang K, Li Y, Wang Z, Liu Q, Wang C, Liu S
Journal of cellular physiology 2020 Jun;235(6):5111-5119
Journal of cellular physiology 2020 Jun;235(6):5111-5119
RhoJ Regulates α5β1 Integrin Trafficking to Control Fibronectin Remodeling during Angiogenesis.
Sundararaman A, Fukushima Y, Norman JC, Uemura A, Mellor H
Current biology : CB 2020 Jun 8;30(11):2146-2155.e5
Current biology : CB 2020 Jun 8;30(11):2146-2155.e5
Transcriptomic analysis of the mechanisms of alleviating renal interstitial fibrosis using the traditional Chinese medicine Kangxianling in a rat model.
Jiang Y, Zhu Y, Zhen T, Li J, Xing K, He L, Zhu S
Scientific reports 2020 Jun 30;10(1):10682
Scientific reports 2020 Jun 30;10(1):10682
Klotho is regulated by transcription factor Sp1 in renal tubular epithelial cells.
Li Y, Liu Y, Wang K, Huang Y, Han W, Xiong J, Yang K, Liu M, Xiao T, Liu C, He T, Bi X, Zhang J, Zhang B, Zhao J
BMC molecular and cell biology 2020 Jun 22;21(1):45
BMC molecular and cell biology 2020 Jun 22;21(1):45
Modification of PLGA Scaffold by MSC-Derived Extracellular Matrix Combats Macrophage Inflammation to Initiate Bone Regeneration via TGF-β-Induced Protein.
Deng M, Tan J, Hu C, Hou T, Peng W, Liu J, Yu B, Dai Q, Zhou J, Yang Y, Dong R, Ruan C, Dong S, Xu J
Advanced healthcare materials 2020 Jul;9(13):e2000353
Advanced healthcare materials 2020 Jul;9(13):e2000353
LRIG3 represses cell motility by inhibiting slug via inactivating ERK signaling in human colorectal cancer.
Zeng K, Chen X, Xu M, Liu X, Li C, Xu X, Pan B, Qin J, He B, Pan Y, Huiling S, Xu T, Wang S
IUBMB life 2020 Jul;72(7):1393-1403
IUBMB life 2020 Jul;72(7):1393-1403
The effect of lncRNA-ARAP1-AS2/ARAP1 on high glucose-induced cytoskeleton rearrangement and epithelial-mesenchymal transition in human renal tubular epithelial cells.
Li L, Xu L, Wen S, Yang Y, Li X, Fan Q
Journal of cellular physiology 2020 Jul;235(7-8):5787-5795
Journal of cellular physiology 2020 Jul;235(7-8):5787-5795
Connexin 43 prevents the progression of diabetic renal tubulointerstitial fibrosis by regulating the SIRT1-HIF-1α signaling pathway.
Sun X, Huang K, Haiming X, Lin Z, Yang Y, Zhang M, Liu P, Huang H
Clinical science (London, England : 1979) 2020 Jul 17;134(13):1573-1592
Clinical science (London, England : 1979) 2020 Jul 17;134(13):1573-1592
Type I collagen facilitates safe and reliable expansion of human dental pulp stem cells in xenogeneic serum-free culture.
Mochizuki M, Sagara H, Nakahara T
Stem cell research & therapy 2020 Jul 14;11(1):267
Stem cell research & therapy 2020 Jul 14;11(1):267
Phloretin ameliorates hyperuricemia-induced chronic renal dysfunction through inhibiting NLRP3 inflammasome and uric acid reabsorption.
Cui D, Liu S, Tang M, Lu Y, Zhao M, Mao R, Wang C, Yuan Y, Li L, Chen Y, Cheng J, Lu Y, Liu J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 Jan;66:153111
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 Jan;66:153111
miRNA‑342 suppresses renal interstitial fibrosis in diabetic nephropathy by targeting SOX6.
Jiang ZH, Tang YZ, Song HN, Yang M, Li B, Ni CL
International journal of molecular medicine 2020 Jan;45(1):45-52
International journal of molecular medicine 2020 Jan;45(1):45-52
Subcellular trafficking of tubular MDM2 implicates in acute kidney injury to chronic kidney disease transition during multiple low-dose cisplatin exposure.
Su H, Ye C, Lei CT, Tang H, Zeng JY, Yi F, Zhang C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jan;34(1):1620-1636
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jan;34(1):1620-1636
Hydrogen sulfide attenuates cigarette smoke-induced airway remodeling by upregulating SIRT1 signaling pathway.
Guan R, Wang J, Cai Z, Li Z, Wang L, Li Y, Xu J, Li D, Yao H, Liu W, Deng B, Lu W
Redox biology 2020 Jan;28:101356
Redox biology 2020 Jan;28:101356
Celastrol exerts anti-inflammatory effect in liver fibrosis via activation of AMPK-SIRT3 signalling.
Wang Y, Li C, Gu J, Chen C, Duanmu J, Miao J, Yao W, Tao J, Tu M, Xiong B, Zhao L, Liu Z
Journal of cellular and molecular medicine 2020 Jan;24(1):941-953
Journal of cellular and molecular medicine 2020 Jan;24(1):941-953
Connexin32 ameliorates renal fibrosis in diabetic mice by promoting K48-linked NADPH oxidase 4 polyubiquitination and degradation.
Chen Z, Sun X, Chen Q, Lan T, Huang K, Xiao H, Lin Z, Yang Y, Liu P, Huang H
British journal of pharmacology 2020 Jan;177(1):145-160
British journal of pharmacology 2020 Jan;177(1):145-160
Gentiopicroside activates the bile acid receptor Gpbar1 (TGR5) to repress NF-kappaB pathway and ameliorate diabetic nephropathy.
Xiao H, Sun X, Liu R, Chen Z, Lin Z, Yang Y, Zhang M, Liu P, Quan S, Huang H
Pharmacological research 2020 Jan;151:104559
Pharmacological research 2020 Jan;151:104559
Long non-coding RNA RNF7 promotes the cardiac fibrosis in rat model via miR-543/THBS1 axis and TGFβ1 activation.
Ouyang F, Liu X, Liu G, Qiu H, He Y, Hu H, Jiang P
Aging 2020 Jan 8;12(1):996-1010
Aging 2020 Jan 8;12(1):996-1010
GSPE alleviates renal fibrosis by inhibiting the activation of C3/ HMGB1/ TGF-β1 pathway.
Wang K, Wei H, Zhan J, Liang X, Zhang C, Liu Y, Xu G
Chemico-biological interactions 2020 Jan 25;316:108926
Chemico-biological interactions 2020 Jan 25;316:108926
miR-485 suppresses inflammation and proliferation of mesangial cells in an in vitro model of diabetic nephropathy by targeting NOX5.
Wu J, Lu K, Zhu M, Xie X, Ding Y, Shao X, Chen Y, Liu J, Xu M, Xu Y, Zhou J, Shen X, Zhu C
Biochemical and biophysical research communications 2020 Jan 22;521(4):984-990
Biochemical and biophysical research communications 2020 Jan 22;521(4):984-990
Fibroblasts Derived From Human Adipose Stem Cells Produce More Effective Extracellular Matrix and Migrate Faster Compared to Primary Dermal Fibroblasts.
Gersch RP, Raum JC, Calvert C, Percec I
Aesthetic surgery journal 2020 Jan 1;40(1):108-117
Aesthetic surgery journal 2020 Jan 1;40(1):108-117
miR-363-3p inhibits migration, invasion, and epithelial-mesenchymal transition by targeting NEDD9 and SOX4 in non-small-cell lung cancer.
Chang J, Gao F, Chu H, Lou L, Wang H, Chen Y
Journal of cellular physiology 2020 Feb;235(2):1808-1820
Journal of cellular physiology 2020 Feb;235(2):1808-1820
Anti-Adhesive, Platelet Gathering Effects of c-RGD Modified Poly(p-dioxanone-co-l-Phe) Electrospun Membrane and Its Comprehensive Application in Intestinal Anastomosis.
Wang B, Feng C, Dang J, Niu L, Shen C, Yang X, Zhang T, Zhang X
Macromolecular bioscience 2020 Feb;20(2):e1900344
Macromolecular bioscience 2020 Feb;20(2):e1900344
A self-assembling peptide hydrogel-based drug co-delivery platform to improve tissue repair after ischemia-reperfusion injury.
Liu S, Zhao M, Zhou Y, Li L, Wang C, Yuan Y, Li L, Liao G, Bresette W, Chen Y, Cheng J, Lu Y, Liu J
Acta biomaterialia 2020 Feb;103:102-114
Acta biomaterialia 2020 Feb;103:102-114
IL-6 trans-signaling drives a STAT3-dependent pathway that leads to structural alterations of the peritoneal membrane.
Yang X, Yan H, Jiang N, Yu Z, Yuan J, Ni Z, Fang W
American journal of physiology. Renal physiology 2020 Feb 1;318(2):F338-F353
American journal of physiology. Renal physiology 2020 Feb 1;318(2):F338-F353
Polydatin attenuates renal fibrosis in diabetic mice through regulating the Cx32-Nox4 signaling pathway.
Chen ZQ, Sun XH, Li XJ, Xu ZC, Yang Y, Lin ZY, Xiao HM, Zhang M, Quan SJ, Huang HQ
Acta pharmacologica Sinica 2020 Dec;41(12):1587-1596
Acta pharmacologica Sinica 2020 Dec;41(12):1587-1596
Disruption of retinoid homeostasis induces RBP4 overproduction in diabetes: O-GlcNAcylation involved.
Shin SJ, Chen CH, Kuo WC, Chan HC, Chan HC, Lin KD, Ke LY
Metabolism: clinical and experimental 2020 Dec;113:154403
Metabolism: clinical and experimental 2020 Dec;113:154403
Stem-cell-derived ECM sheet-implant complexes for enhancing osseointegration.
Feng Y, Jiang Z, Zhang Y, Miao X, Yu Q, Xie Z, Yang G
Biomaterials science 2020 Dec 7;8(23):6647-6656
Biomaterials science 2020 Dec 7;8(23):6647-6656
Regulation of FN1 degradation by the p62/SQSTM1-dependent autophagy-lysosome pathway in HNSCC.
Liu X, Meng L, Li X, Li D, Liu Q, Chen Y, Li X, Bu W, Sun H
International journal of oral science 2020 Dec 14;12(1):34
International journal of oral science 2020 Dec 14;12(1):34
Transcriptome analysis reveals a protective role of liver X receptor alpha against silica particle-induced experimental silicosis.
Yao W, Yang P, Qi Y, Jin L, Zhao A, Ding M, Wang D, Li Y, Hao C
The Science of the total environment 2020 Dec 10;747:141531
The Science of the total environment 2020 Dec 10;747:141531
Metformin inhibits extracellular matrix accumulation, inflammation and proliferation of mesangial cells in diabetic nephropathy by regulating H19/miR-143-3p/TGF-β1 axis.
Xu J, Xiang P, Liu L, Sun J, Ye S
The Journal of pharmacy and pharmacology 2020 Aug;72(8):1101-1109
The Journal of pharmacy and pharmacology 2020 Aug;72(8):1101-1109
Melatonin Ameliorates Renal Fibrosis Through the Inhibition of NF-κB and TGF-β1/Smad3 Pathways in db/db Diabetic Mice.
Fan Z, Qi X, Yang W, Xia L, Wu Y
Archives of medical research 2020 Aug;51(6):524-534
Archives of medical research 2020 Aug;51(6):524-534
Possible involvement of TGF‑β‑SMAD‑mediated epithelial‑mesenchymal transition in pro‑metastatic property of PAX6.
Jin M, Gao D, Wang R, Sik A, Liu K
Oncology reports 2020 Aug;44(2):555-564
Oncology reports 2020 Aug;44(2):555-564
miR-143 inhibits renal cell carcinoma cells metastatic potential by suppressing ABL2.
Xu B, Wang C, Wang YL, Chen SQ, Wu JP, Zhu WD, Wang CY, Guan H, Guan C, You ZH, Chen M
The Kaohsiung journal of medical sciences 2020 Aug;36(8):592-598
The Kaohsiung journal of medical sciences 2020 Aug;36(8):592-598
Hsa-miR-425-5p promotes tumor growth and metastasis by activating the CTNND1-mediated β-catenin pathway and EMT in colorectal cancer.
Liu D, Zhang H, Cui M, Chen C, Feng Y
Cell cycle (Georgetown, Tex.) 2020 Aug;19(15):1917-1927
Cell cycle (Georgetown, Tex.) 2020 Aug;19(15):1917-1927
Trichostatin A Alleviates Renal Interstitial Fibrosis Through Modulation of the M2 Macrophage Subpopulation.
Tseng WC, Tsai MT, Chen NJ, Tarng DC
International journal of molecular sciences 2020 Aug 19;21(17)
International journal of molecular sciences 2020 Aug 19;21(17)
RIG-I aggravates interstitial fibrosis via c-Myc-mediated fibroblast activation in UUO mice.
Zhou Z, Ni J, Li J, Huo C, Miao N, Yin F, Cheng Q, Xu D, Xie H, Chen P, Zheng P, Zhang Y, Zhou L, Zhang W, Yu C, Liu J, Lu L
Journal of molecular medicine (Berlin, Germany) 2020 Apr;98(4):527-540
Journal of molecular medicine (Berlin, Germany) 2020 Apr;98(4):527-540
LncRNA LINP1 confers tamoxifen resistance and negatively regulated by ER signaling in breast cancer.
Ma T, Liang Y, Li Y, Song X, Zhang N, Li X, Chen B, Zhao W, Wang L, Yang Q
Cellular signalling 2020 Apr;68:109536
Cellular signalling 2020 Apr;68:109536
Micro-vesicles from mesenchymal stem cells over-expressing miR-34a inhibit transforming growth factor-β1-induced epithelial-mesenchymal transition in renal tubular epithelial cells in vitro.
He J, Jiang YL, Wang Y, Tian XJ, Sun SR
Chinese medical journal 2020 Apr 5;133(7):800-807
Chinese medical journal 2020 Apr 5;133(7):800-807
Wu-Mei-Wan ameliorates chronic colitis-associated intestinal fibrosis through inhibiting fibroblast activation.
Wu F, Shao Q, Hu M, Zhao Y, Dong R, Fang K, Xu L, Zou X, Lu F, Li J, Chen G
Journal of ethnopharmacology 2020 Apr 24;252:112580
Journal of ethnopharmacology 2020 Apr 24;252:112580
MicroRNA-183 regulates lipopolysaccharide-induced oxidative stress of hippocampal neurons by targeting the fibronectin 1 gene.
Xie Q, Feng L, Zhang C, Gan L
Neuroscience letters 2020 Apr 23;725:134902
Neuroscience letters 2020 Apr 23;725:134902
Exosomal miR-125a-5p derived from silica-exposed macrophages induces fibroblast transdifferentiation.
Wang D, Hao C, Zhang L, Zhang J, Liu S, Li Y, Qu Y, Zhao Y, Huang R, Wei J, Yao W
Ecotoxicology and environmental safety 2020 Apr 1;192:110253
Ecotoxicology and environmental safety 2020 Apr 1;192:110253
Kidney-targeted rhein-loaded liponanoparticles for diabetic nephropathy therapy via size control and enhancement of renal cellular uptake.
Wang G, Li Q, Chen D, Wu B, Wu Y, Tong W, Huang P
Theranostics 2019;9(21):6191-6208
Theranostics 2019;9(21):6191-6208
FOXO1 Overexpression Attenuates Tubulointerstitial Fibrosis and Apoptosis in Diabetic Kidneys by Ameliorating Oxidative Injury via TXNIP-TRX.
Ji L, Wang Q, Huang F, An T, Guo F, Zhao Y, Liu Y, He Y, Song Y, Qin G
Oxidative medicine and cellular longevity 2019;2019:3286928
Oxidative medicine and cellular longevity 2019;2019:3286928
Stem Cells from Human Exfoliated Deciduous Teeth Ameliorate Diabetic Nephropathy In Vivo and In Vitro by Inhibiting Advanced Glycation End Product-Activated Epithelial-Mesenchymal Transition.
Rao N, Wang X, Xie J, Li J, Zhai Y, Li X, Fang T, Wang Y, Zhao Y, Ge L
Stem cells international 2019;2019:2751475
Stem cells international 2019;2019:2751475
TGF-β1 Induces Epithelial-Mesenchymal Transition of Chronic Sinusitis with Nasal Polyps through MicroRNA-21.
Li X, Li C, Zhu G, Yuan W, Xiao ZA
International archives of allergy and immunology 2019;179(4):304-319
International archives of allergy and immunology 2019;179(4):304-319
Presence and function of stress granules in atrial fibrillation.
Dong G, Liang F, Sun B, Wang C, Liu Y, Guan X, Yang B, Xiu C, Yang N, Liu F, Lu T, Han W
PloS one 2019;14(4):e0213769
PloS one 2019;14(4):e0213769
Development and validation of a novel phonomimetic bioreactor.
Kirsch A, Hortobagyi D, Stachl T, Karbiener M, Grossmann T, Gerstenberger C, Gugatschka M
PloS one 2019;14(3):e0213788
PloS one 2019;14(3):e0213788
CLK3 Is A Direct Target Of miR-144 And Contributes To Aggressive Progression In Hepatocellular Carcinoma.
Li H, Cui X, Hu Q, Chen X, Zhou P
OncoTargets and therapy 2019;12:9201-9213
OncoTargets and therapy 2019;12:9201-9213
Ursolic Acid Treatment Alleviates Diabetic Kidney Injury By Regulating The ARAP1/AT1R Signaling Pathway.
Ma TK, Xu L, Lu LX, Cao X, Li X, Li LL, Wang X, Fan QL
Diabetes, metabolic syndrome and obesity : targets and therapy 2019;12:2597-2608
Diabetes, metabolic syndrome and obesity : targets and therapy 2019;12:2597-2608
A small molecule inhibitor MCC950 ameliorates kidney injury in diabetic nephropathy by inhibiting NLRP3 inflammasome activation.
Zhang C, Zhu X, Li L, Ma T, Shi M, Yang Y, Fan Q
Diabetes, metabolic syndrome and obesity : targets and therapy 2019;12:1297-1309
Diabetes, metabolic syndrome and obesity : targets and therapy 2019;12:1297-1309
Low-molecular-weight fucoidan attenuates bleomycin-induced pulmonary fibrosis: possible role in inhibiting TGF-β1-induced epithelial-mesenchymal transition through ERK pathway.
Wang L, Zhang P, Li X, Zhang Y, Zhan Q, Wang C
American journal of translational research 2019;11(4):2590-2602
American journal of translational research 2019;11(4):2590-2602
Dapagliflozin Attenuates Renal Tubulointerstitial Fibrosis Associated With Type 1 Diabetes by Regulating STAT1/TGFβ1 Signaling.
Huang F, Zhao Y, Wang Q, Hillebrands JL, van den Born J, Ji L, An T, Qin G
Frontiers in endocrinology 2019;10:441
Frontiers in endocrinology 2019;10:441
lncRNA NR_038323 Suppresses Renal Fibrosis in Diabetic Nephropathy by Targeting the miR-324-3p/DUSP1 Axis.
Ge Y, Wang J, Wu D, Zhou Y, Qiu S, Chen J, Zhu X, Xiang X, Li H, Zhang D
Molecular therapy. Nucleic acids 2019 Sep 6;17:741-753
Molecular therapy. Nucleic acids 2019 Sep 6;17:741-753
Germacrane Sesquiterpenoids as a New Type of Anticardiac Fibrosis Agent Targeting Transforming Growth Factor β Type I Receptor.
Lou LL, Ni FQ, Chen L, Shaker S, Li W, Wang R, Tang GH, Yin S
Journal of medicinal chemistry 2019 Sep 12;62(17):7961-7975
Journal of medicinal chemistry 2019 Sep 12;62(17):7961-7975
Plasma fractalkine levels are associated with renal inflammation and outcomes in immunoglobulin A nephropathy.
Luo R, Guo SM, Li YQ, Yang Y, Li ML, Han M, He XF, Ge SW, Xu G
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2019 Sep 1;34(9):1549-1558
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2019 Sep 1;34(9):1549-1558
Pioglitazone attenuates kidney fibrosis via miR-21-5p modulation.
Sun L, Xu T, Chen Y, Qu W, Sun D, Song X, Yuan Q, Yao L
Life sciences 2019 Sep 1;232:116609
Life sciences 2019 Sep 1;232:116609
Potential role of M2 macrophage polarization in ventilator-induced lung fibrosis.
Wang L, Zhang Y, Zhang N, Xia J, Zhan Q, Wang C
International immunopharmacology 2019 Oct;75:105795
International immunopharmacology 2019 Oct;75:105795
FoxO1-mediated inhibition of STAT1 alleviates tubulointerstitial fibrosis and tubule apoptosis in diabetic kidney disease.
Huang F, Wang Q, Guo F, Zhao Y, Ji L, An T, Song Y, Liu Y, He Y, Qin G
EBioMedicine 2019 Oct;48:491-504
EBioMedicine 2019 Oct;48:491-504
TNF-α Regulates ITGβ1 and SYND4 Expression in Nucleus Pulposus Cells: Activation of FAK/PI3K Signaling.
Wu X, Li S, Wang K, Hua W, Li S, Song Y, Zhang Y, Yang S, Yang C
Inflammation 2019 Oct;42(5):1575-1584
Inflammation 2019 Oct;42(5):1575-1584
RNA-Seq analysis of potential lncRNAs and genes for the anti-renal fibrotic effect of norcantharidin.
Xiao H, Liao Y, Tang C, Xiao Z, Luo H, Li J, Liu H, Sun L, Zeng D, Li Y
Journal of cellular biochemistry 2019 Oct;120(10):17354-17367
Journal of cellular biochemistry 2019 Oct;120(10):17354-17367
Rhodojaponin II attenuates kidney injury by regulating TGF-β1/Smad pathway in mice with adriamycin nephropathy.
Qiu Y, Zhou J, Zhang H, Zhou H, Tang H, Lei C, Ye C, You C, Chen Y, Wang Y, Xiong J, Su H, Yao G, Zhang C
Journal of ethnopharmacology 2019 Oct 28;243:112078
Journal of ethnopharmacology 2019 Oct 28;243:112078
NLRP3 inflammasome inhibition attenuates cisplatin-induced renal fibrosis by decreasing oxidative stress and inflammation.
Li S, Lin Q, Shao X, Mou S, Gu L, Wang L, Zhang Z, Shen J, Zhou Y, Qi C, Jin H, Pang H, Ni Z
Experimental cell research 2019 Oct 1;383(1):111488
Experimental cell research 2019 Oct 1;383(1):111488
Genetic loss of Gas6/Mer pathway attenuates silica-induced lung inflammation and fibrosis in mice.
Li W, Xie L, Ma J, Yang M, Wang B, Xu Y, Fan L, Mu G, Shi T, Chen W
Toxicology letters 2019 Oct 1;313:178-187
Toxicology letters 2019 Oct 1;313:178-187
Role of CCR2 in the Development of Streptozotocin-Treated Diabetic Cardiomyopathy.
Tan X, Hu L, Shu Z, Chen L, Li X, Du M, Sun D, Mao X, Deng S, Huang K, Zhang F
Diabetes 2019 Nov;68(11):2063-2073
Diabetes 2019 Nov;68(11):2063-2073
G9a and histone deacetylases are crucial for Snail2-mediated E-cadherin repression and metastasis in hepatocellular carcinoma.
Hu Y, Zheng Y, Dai M, Wang X, Wu J, Yu B, Zhang H, Cui Y, Kong W, Wu H, Yu X
Cancer science 2019 Nov;110(11):3442-3452
Cancer science 2019 Nov;110(11):3442-3452
ROCK2 Confers Acquired Gemcitabine Resistance in Pancreatic Cancer Cells by Upregulating Transcription Factor ZEB1.
Zhou Y, Zhou Y, Wang K, Li T, Zhang M, Yang Y, Wang R, Hu R
Cancers 2019 Nov 27;11(12)
Cancers 2019 Nov 27;11(12)
HIC-5 in cancer-associated fibroblasts contributes to esophageal squamous cell carcinoma progression.
Du X, Xu Q, Pan D, Xu D, Niu B, Hong W, Zhang R, Li X, Chen S
Cell death & disease 2019 Nov 18;10(12):873
Cell death & disease 2019 Nov 18;10(12):873
SREBP1, targeted by miR-18a-5p, modulates epithelial-mesenchymal transition in breast cancer via forming a co-repressor complex with Snail and HDAC1/2.
Zhang N, Zhang H, Liu Y, Su P, Zhang J, Wang X, Sun M, Chen B, Zhao W, Wang L, Wang H, Moran MS, Haffty BG, Yang Q
Cell death and differentiation 2019 May;26(5):843-859
Cell death and differentiation 2019 May;26(5):843-859
MicroRNA-34a Promotes Renal Fibrosis by Downregulation of Klotho in Tubular Epithelial Cells.
Liu Y, Bi X, Xiong J, Han W, Xiao T, Xu X, Yang K, Liu C, Jiang W, He T, Yu Y, Li Y, Zhang J, Zhang B, Zhao J
Molecular therapy : the journal of the American Society of Gene Therapy 2019 May 8;27(5):1051-1065
Molecular therapy : the journal of the American Society of Gene Therapy 2019 May 8;27(5):1051-1065
Inhibition of lymphatic proliferation by the selective VEGFR-3 inhibitor SAR131675 ameliorates diabetic nephropathy in db/db mice.
Hwang SD, Song JH, Kim Y, Lim JH, Kim MY, Kim EN, Hong YA, Chung S, Choi BS, Kim YS, Park CW
Cell death & disease 2019 Mar 4;10(3):219
Cell death & disease 2019 Mar 4;10(3):219
Intervertebral disc regeneration with an adipose mesenchymal stem cell-derived tissue-engineered construct in a rat nucleotomy model.
Ishiguro H, Kaito T, Yarimitsu S, Hashimoto K, Okada R, Kushioka J, Chijimatsu R, Takenaka S, Makino T, Sakai Y, Moriguchi Y, Otsuru S, Hart DA, Fujie H, Nakamura N, Yoshikawa H
Acta biomaterialia 2019 Mar 15;87:118-129
Acta biomaterialia 2019 Mar 15;87:118-129
Ribes diacanthum Pall (RDP) ameliorates UUO-induced renal fibrosis via both canonical and non-canonical TGF-β signaling pathways in mice.
Gu L, Wang Y, Yang G, Tilyek A, Zhang C, Li S, Yu B, Chai C, Cao Z
Journal of ethnopharmacology 2019 Mar 1;231:302-310
Journal of ethnopharmacology 2019 Mar 1;231:302-310
Three kinds of corneal host cells contribute differently to corneal neovascularization.
Yu H, Sun L, Cui J, Li Y, Yan Y, Wei X, Wang C, Song F, Jiang W, Liu Y, Ge H, Qian H, Li X, Tang X, Liu P
EBioMedicine 2019 Jun;44:542-553
EBioMedicine 2019 Jun;44:542-553
EZH2-DNMT1-mediated epigenetic silencing of miR-142-3p promotes metastasis through targeting ZEB2 in nasopharyngeal carcinoma.
Li Y, He Q, Wen X, Hong X, Yang X, Tang X, Zhang P, Lei Y, Sun Y, Zhang J, Wang Y, Ma J, Liu N
Cell death and differentiation 2019 Jun;26(6):1089-1106
Cell death and differentiation 2019 Jun;26(6):1089-1106
RNF128 Promotes Invasion and Metastasis Via the EGFR/MAPK/MMP-2 Pathway in Esophageal Squamous Cell Carcinoma.
Gao J, Wang Y, Yang J, Zhang W, Meng K, Sun Y, Li Y, He QY
Cancers 2019 Jun 18;11(6)
Cancers 2019 Jun 18;11(6)
Role of PM(2.5) in the development and progression of COPD and its mechanisms.
Zhao J, Li M, Wang Z, Chen J, Zhao J, Xu Y, Wei X, Wang J, Xie J
Respiratory research 2019 Jun 13;20(1):120
Respiratory research 2019 Jun 13;20(1):120
Aspirin inhibits inflammation and scar formation in the injury tendon healing through regulating JNK/STAT-3 signalling pathway.
Wang Y, He G, Tang H, Shi Y, Kang X, Lyu J, Zhu M, Zhou M, Yang M, Mu M, Chen W, Zhou B, Zhang J, Tang K
Cell proliferation 2019 Jul;52(4):e12650
Cell proliferation 2019 Jul;52(4):e12650
LncRNA PFAR contributes to fibrogenesis in lung fibroblasts through competitively binding to miR-15a.
Sun J, Su W, Zhao X, Shan T, Jin T, Guo Y, Li C, Li R, Zhou Y, Shan H, Sun X, Liang H
Bioscience reports 2019 Jul 31;39(7)
Bioscience reports 2019 Jul 31;39(7)
Sphingosine kinase 1 promotes the metastasis of colorectal cancer by inducing the epithelial‑mesenchymal transition mediated by the FAK/AKT/MMPs axis.
Liu SQ, Xu CY, Wu WH, Fu ZH, He SW, Qin MB, Huang JA
International journal of oncology 2019 Jan;54(1):41-52
International journal of oncology 2019 Jan;54(1):41-52
Loss of TMEM126A promotes extracellular matrix remodeling, epithelial-to-mesenchymal transition, and breast cancer metastasis by regulating mitochondrial retrograde signaling.
Sun HF, Yang XL, Zhao Y, Tian Q, Chen MT, Zhao YY, Jin W
Cancer letters 2019 Jan;440-441:189-201
Cancer letters 2019 Jan;440-441:189-201
miR-196a-5p promotes metastasis of colorectal cancer via targeting IκBα.
Xin H, Wang C, Liu Z
BMC cancer 2019 Jan 8;19(1):30
BMC cancer 2019 Jan 8;19(1):30
Tinagl1 Suppresses Triple-Negative Breast Cancer Progression and Metastasis by Simultaneously Inhibiting Integrin/FAK and EGFR Signaling.
Shen M, Jiang YZ, Wei Y, Ell B, Sheng X, Esposito M, Kang J, Hang X, Zheng H, Rowicki M, Zhang L, Shih WJ, Celià-Terrassa T, Liu Y, Cristea I, Shao ZM, Kang Y
Cancer cell 2019 Jan 14;35(1):64-80.e7
Cancer cell 2019 Jan 14;35(1):64-80.e7
Protein kinase C inhibitor chelerythrine attenuates partial unilateral ureteral obstruction induced kidney injury in neonatal rats.
Shi B, Li S, Ju H, Liu X, Li D, Li Y
Life sciences 2019 Jan 1;216:85-91
Life sciences 2019 Jan 1;216:85-91
An improved cellular enucleation method with extracellular matrix and colchicine facilitates the study of nucleocytoplasmic interaction.
Chen Y, Xu LQ, Lin MJ, Zhang W, Zhang ZJ, Xu WC, Yang LJ, Wei CJ
European journal of cell biology 2019 Dec;98(5-8):151045
European journal of cell biology 2019 Dec;98(5-8):151045
Snail2 induced E-cadherin suppression and metastasis in lung carcinoma facilitated by G9a and HDACs.
Hu Y, Zheng Y, Dai M, Wu J, Yu B, Zhang H, Kong W, Wu H, Yu X
Cell adhesion & migration 2019 Dec;13(1):285-292
Cell adhesion & migration 2019 Dec;13(1):285-292
Injectable extracellular vesicle-released self-assembling peptide nanofiber hydrogel as an enhanced cell-free therapy for tissue regeneration.
Zhou Y, Liu S, Zhao M, Wang C, Li L, Yuan Y, Li L, Liao G, Bresette W, Zhang J, Chen Y, Cheng J, Lu Y, Liu J
Journal of controlled release : official journal of the Controlled Release Society 2019 Dec 28;316:93-104
Journal of controlled release : official journal of the Controlled Release Society 2019 Dec 28;316:93-104
Functional significance of U2AF1 S34F mutations in lung adenocarcinomas.
Esfahani MS, Lee LJ, Jeon YJ, Flynn RA, Stehr H, Hui AB, Ishisoko N, Kildebeck E, Newman AM, Bratman SV, Porteus MH, Chang HY, Alizadeh AA, Diehn M
Nature communications 2019 Dec 13;10(1):5712
Nature communications 2019 Dec 13;10(1):5712
MicroRNA-432 is downregulated in cervical cancer and directly targets FN1 to inhibit cell proliferation and invasion.
Wang S, Gao B, Yang H, Liu X, Wu X, Wang W
Oncology letters 2019 Aug;18(2):1475-1482
Oncology letters 2019 Aug;18(2):1475-1482
TGF-β-mediated upregulation of brachyury contributes to constitutively up-regulated type I collagen expression in skin fibroblasts: possible role in systemic sclerosis.
Teng L, Yao G, Gao R, Wang Y, Lin W, Jin Y, Wang Y, Chen H, Wang Z, Chen J
European journal of dermatology : EJD 2019 Aug 1;29(4):359-365
European journal of dermatology : EJD 2019 Aug 1;29(4):359-365
Astaxanthin ameliorates renal interstitial fibrosis and peritubular capillary rarefaction in unilateral ureteral obstruction.
Zhao J, Meng M, Zhang J, Li L, Zhu X, Zhang L, Wang C, Gao M
Molecular medicine reports 2019 Apr;19(4):3168-3178
Molecular medicine reports 2019 Apr;19(4):3168-3178
Effects of SIRT1 silencing on viability, invasion and metastasis of human glioma cell lines.
Li Y, Chen X, Cui Y, Wei Q, Chen S, Wang X
Oncology letters 2019 Apr;17(4):3701-3708
Oncology letters 2019 Apr;17(4):3701-3708
Citrus alkaline extracts prevent fibroblast senescence to ameliorate pulmonary fibrosis via activation of COX-2.
Feng F, Wang Z, Li R, Wu Q, Gu C, Xu Y, Peng W, Han D, Zhou X, Wu J, He H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Apr;112:108669
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Apr;112:108669
LncRNA PFL contributes to cardiac fibrosis by acting as a competing endogenous RNA of let-7d.
Liang H, Pan Z, Zhao X, Liu L, Sun J, Su X, Xu C, Zhou Y, Zhao D, Xu B, Li X, Yang B, Lu Y, Shan H
Theranostics 2018;8(4):1180-1194
Theranostics 2018;8(4):1180-1194
Inhibition of SIRT2 Alleviates Fibroblast Activation and Renal Tubulointerstitial Fibrosis via MDM2.
He FF, You RY, Ye C, Lei CT, Tang H, Su H, Zhang C
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;46(2):451-460
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;46(2):451-460
Kindlin-2 regulates hepatic stellate cells activation and liver fibrogenesis.
Yu J, Hu Y, Gao Y, Li Q, Zeng Z, Li Y, Chen H
Cell death discovery 2018;4:34
Cell death discovery 2018;4:34
Cyclin G2 Suppresses Glomerulosclerosis by Regulating Canonical Wnt Signalling.
Zhao C, Gao J, Li S, Liu Q, Hou X, Liu S, Xing X, Sun M, Wang S, Luo Y
BioMed research international 2018;2018:6938482
BioMed research international 2018;2018:6938482
Kidney-targeted drug delivery via rhein-loaded polyethyleneglycol-co-polycaprolactone-co-polyethylenimine nanoparticles for diabetic nephropathy therapy.
Chen D, Han S, Zhu Y, Hu F, Wei Y, Wang G
International journal of nanomedicine 2018;13:3507-3527
International journal of nanomedicine 2018;13:3507-3527
Wenyang Huazhuo Tongluo formula inhibits fibrosis via suppressing Wnt/β-catenin signaling pathway in a Bleomycin-induced systemic sclerosis mouse model.
Wang Q, Zang W, Han L, Yang L, Ye S, Ouyang J, Zhang C, Bi Y, Zhang C, Bian H
Chinese medicine 2018;13:17
Chinese medicine 2018;13:17
Renal-protective effect of thalidomide in streptozotocin-induced diabetic rats through anti-inflammatory pathway.
Zhang H, Yang Y, Wang Y, Wang B, Li R
Drug design, development and therapy 2018;12:89-98
Drug design, development and therapy 2018;12:89-98
LncRNA UCA1 sponges miR-204-5p to promote migration, invasion and epithelial-mesenchymal transition of glioma cells via upregulation of ZEB1.
Liang C, Yang Y, Guan J, Lv T, Qu S, Fu Q, Zhao H
Pathology, research and practice 2018 Sep;214(9):1474-1481
Pathology, research and practice 2018 Sep;214(9):1474-1481
A novel bioscaffold with naturally-occurring extracellular matrix promotes hepatocyte survival and vessel patency in mouse models of heterologous transplantation.
Yang W, Chen Q, Xia R, Zhang Y, Shuai L, Lai J, You X, Jiang Y, Bie P, Zhang L, Zhang H, Bai L
Biomaterials 2018 Sep;177:52-66
Biomaterials 2018 Sep;177:52-66
lncRNA PFAR Promotes Lung Fibroblast Activation and Fibrosis by Targeting miR-138 to Regulate the YAP1-Twist Axis.
Zhao X, Sun J, Chen Y, Su W, Shan H, Li Y, Wang Y, Zheng N, Shan H, Liang H
Molecular therapy : the journal of the American Society of Gene Therapy 2018 Sep 5;26(9):2206-2217
Molecular therapy : the journal of the American Society of Gene Therapy 2018 Sep 5;26(9):2206-2217
S3I-201 ameliorates tubulointerstitial lesion of the kidneys in MRL/lpr mice.
Du Y, Zhang W, Liu S, Feng X, Gao F, Liu Q
Biochemical and biophysical research communications 2018 Sep 3;503(1):177-180
Biochemical and biophysical research communications 2018 Sep 3;503(1):177-180
NMDA receptor activation inhibits the antifibrotic effect of BM-MSCs on bleomycin-induced pulmonary fibrosis.
Li X, Li C, Tang Y, Huang Y, Cheng Q, Huang X, Zhao F, Hao C, Feng D, Xu J, Han J, Tang S, Liu W, Yue S, Luo Z
American journal of physiology. Lung cellular and molecular physiology 2018 Sep 1;315(3):L404-L421
American journal of physiology. Lung cellular and molecular physiology 2018 Sep 1;315(3):L404-L421
lncRNA PFAL promotes lung fibrosis through CTGF by competitively binding miR-18a.
Li X, Yu T, Shan H, Jiang H, Sun J, Zhao X, Su W, Yang L, Shan H, Liang H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Oct;32(10):5285-5297
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Oct;32(10):5285-5297
Inhibition of lncRNA PFRL prevents pulmonary fibrosis by disrupting the miR-26a/smad2 loop.
Jiang H, Chen Y, Yu T, Zhao X, Shan H, Sun J, Zhang L, Li X, Shan H, Liang H
American journal of physiology. Lung cellular and molecular physiology 2018 Oct 1;315(4):L563-L575
American journal of physiology. Lung cellular and molecular physiology 2018 Oct 1;315(4):L563-L575
The pro-metastasis effect of circANKS1B in breast cancer.
Zeng K, He B, Yang BB, Xu T, Chen X, Xu M, Liu X, Sun H, Pan Y, Wang S
Molecular cancer 2018 Nov 19;17(1):160
Molecular cancer 2018 Nov 19;17(1):160
Effects of Resveratrol on the Renin-Angiotensin System in the Aging Kidney.
Jang IA, Kim EN, Lim JH, Kim MY, Ban TH, Yoon HE, Park CW, Chang YS, Choi BS
Nutrients 2018 Nov 12;10(11)
Nutrients 2018 Nov 12;10(11)
Towards an in vitro fibrogenesis model of human vocal fold scarring.
Graupp M, Rinner B, Frisch MT, Weiss G, Fuchs J, Sundl M, El-Heliebi A, Moser G, Kamolz LP, Karbiener M, Gugatschka M
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 2018 May;275(5):1211-1218
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 2018 May;275(5):1211-1218
Methanol fixed fibroblasts serve as feeder cells to maintain stem cells in the pluripotent state in vitro.
Ren Y, Ma Z, Yu T, Ling M, Wang H
Scientific reports 2018 May 17;8(1):7780
Scientific reports 2018 May 17;8(1):7780
Rotenone ameliorates chronic renal injury caused by acute ischemia/reperfusion.
Zhang W, Sha Y, Wei K, Wu C, Ding D, Yang Y, Zhu C, Zhang Y, Ding G, Zhang A, Jia Z, Huang S
Oncotarget 2018 May 11;9(36):24199-24208
Oncotarget 2018 May 11;9(36):24199-24208
Fibronectin Facilitates Enterovirus 71 Infection by Mediating Viral Entry.
He QQ, Ren S, Xia ZC, Cheng ZK, Peng NF, Zhu Y
Journal of virology 2018 May 1;92(9)
Journal of virology 2018 May 1;92(9)
LincRNA 1700020I14Rik alleviates cell proliferation and fibrosis in diabetic nephropathy via miR-34a-5p/Sirt1/HIF-1α signaling.
Li A, Peng R, Sun Y, Liu H, Peng H, Zhang Z
Cell death & disease 2018 May 1;9(5):461
Cell death & disease 2018 May 1;9(5):461
The protective effect of resveratrol on vascular aging by modulation of the renin-angiotensin system.
Kim EN, Kim MY, Lim JH, Kim Y, Shin SJ, Park CW, Kim YS, Chang YS, Yoon HE, Choi BS
Atherosclerosis 2018 Mar;270:123-131
Atherosclerosis 2018 Mar;270:123-131
RhoA/Rho-kinase triggers epithelial-mesenchymal transition in mesothelial cells and contributes to the pathogenesis of dialysis-related peritoneal fibrosis.
Wang Q, Yang X, Xu Y, Shen Z, Cheng H, Cheng F, Liu X, Wang R
Oncotarget 2018 Mar 6;9(18):14397-14412
Oncotarget 2018 Mar 6;9(18):14397-14412
Autophagy inhibition attenuates the induction of anti-inflammatory effect of catalpol in liver fibrosis.
Liu Z, Zhu P, Zhang L, Xiong B, Tao J, Guan W, Li C, Chen C, Gu J, Duanmu J, Zhang W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jul;103:1262-1271
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jul;103:1262-1271
Administration of cytokine-induced myeloid-derived suppressor cells ameliorates renal fibrosis in diabetic mice.
Hsieh CC, Lin CL, He JT, Chiang M, Wang Y, Tsai YC, Hung CH, Chang PJ
Stem cell research & therapy 2018 Jul 4;9(1):183
Stem cell research & therapy 2018 Jul 4;9(1):183
Stachydrine ameliorates carbon tetrachloride-induced hepatic fibrosis by inhibiting inflammation, oxidative stress and regulating MMPs/TIMPs system in rats.
Zhang J, Yang A, Wu Y, Guan W, Xiong B, Peng X, Wei X, Chen C, Liu Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jan;97:1586-1594
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jan;97:1586-1594
β-Arrestin-1 deficiency ameliorates renal interstitial fibrosis by blocking Wnt1/β-catenin signaling in mice.
Xu H, Li Q, Liu J, Zhu J, Li L, Wang Z, Zhang Y, Sun Y, Sun J, Wang R, Yi F
Journal of molecular medicine (Berlin, Germany) 2018 Jan;96(1):97-109
Journal of molecular medicine (Berlin, Germany) 2018 Jan;96(1):97-109
Aucubin Protects against TGFβ1-Induced Cardiac Fibroblasts Activation by Mediating the AMPKα/mTOR Signaling Pathway.
Xiao Y, Chang W, Wu QQ, Jiang XH, Duan MX, Jin YG, Tang QZ
Planta medica 2018 Jan;84(2):91-99
Planta medica 2018 Jan;84(2):91-99
Regulation of pancreatic stellate cell activation by Notch3.
Song H, Zhang Y
BMC cancer 2018 Jan 5;18(1):36
BMC cancer 2018 Jan 5;18(1):36
PLZF inhibits proliferation and metastasis of gallbladder cancer by regulating IFIT2.
Shen H, Zhan M, Zhang Y, Huang S, Xu S, Huang X, He M, Yao Y, Man M, Wang J
Cell death & disease 2018 Jan 22;9(2):71
Cell death & disease 2018 Jan 22;9(2):71
SIRT3 prevents angiotensin II-induced renal tubular epithelial-mesenchymal transition by ameliorating oxidative stress and mitochondrial dysfunction.
He P, Li Z, Yue Z, Gao H, Feng G, Wang P, Huang Y, Luo W, Hong H, Liang L, Chen S, Liu P
Molecular and cellular endocrinology 2018 Jan 15;460:1-13
Molecular and cellular endocrinology 2018 Jan 15;460:1-13
Salvianolic acid B inhibits myofibroblast transdifferentiation in experimental pulmonary fibrosis via the up-regulation of Nrf2.
Liu M, Xu H, Zhang L, Zhang C, Yang L, Ma E, Liu L, Li Y
Biochemical and biophysical research communications 2018 Jan 1;495(1):325-331
Biochemical and biophysical research communications 2018 Jan 1;495(1):325-331
Nicotine Induces Progressive Properties of Lung Adenocarcinoma A549 Cells by Inhibiting Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Expression and Plasma Membrane Localization.
Li H, Ma N, Wang J, Wang Y, Yuan C, Wu J, Luo M, Yang J, Chen J, Shi J, Liu X
Technology in cancer research & treatment 2018 Jan 1;17:1533033818809984
Technology in cancer research & treatment 2018 Jan 1;17:1533033818809984
Autophagy promotes fibrosis and apoptosis in the peritoneum during long-term peritoneal dialysis.
Wu J, Xing C, Zhang L, Mao H, Chen X, Liang M, Wang F, Ren H, Cui H, Jiang A, Wang Z, Zou M, Ji Y
Journal of cellular and molecular medicine 2018 Feb;22(2):1190-1201
Journal of cellular and molecular medicine 2018 Feb;22(2):1190-1201
Ursolic Acid Attenuates High Glucose-Mediated Mesangial Cell Injury by Inhibiting the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR) Signaling Pathway.
Wang EM, Fan QL, Yue Y, Xu L
Medical science monitor : international medical journal of experimental and clinical research 2018 Feb 11;24:846-854
Medical science monitor : international medical journal of experimental and clinical research 2018 Feb 11;24:846-854
A cell culture condition that induces the mesenchymal-epithelial transition of dedifferentiated porcine retinal pigment epithelial cells.
Tian H, Xu JY, Tian Y, Cao Y, Lian C, Ou Q, Wu B, Jin C, Gao F, Wang J, Zhang J, Zhang J, Li W, Lu L, Xu GT
Experimental eye research 2018 Dec;177:160-172
Experimental eye research 2018 Dec;177:160-172
CAPE-pNO(2) attenuates diabetic cardiomyopathy through the NOX4/NF-κB pathway in STZ-induced diabetic mice.
Fan L, Xiao Q, Zhang L, Wang X, Huang Q, Li S, Zhao X, Li Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Dec;108:1640-1650
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Dec;108:1640-1650
Binding of a glaucoma-associated myocilin variant to the αB-crystallin chaperone impedes protein clearance in trabecular meshwork cells.
Lynch JM, Li B, Katoli P, Xiang C, Leehy B, Rangaswamy N, Saenz-Vash V, Wang YK, Lei H, Nicholson TB, Meredith E, Rice DS, Prasanna G, Chen A
The Journal of biological chemistry 2018 Dec 28;293(52):20137-20156
The Journal of biological chemistry 2018 Dec 28;293(52):20137-20156
Tamoxifen attenuates dialysate-induced peritoneal fibrosis by inhibiting GSK-3β/β-catenin axis activation.
Yan P, Tang H, Chen X, Ji S, Jin W, Zhang J, Shen J, Deng H, Zhao X, Shen Q, Huang H
Bioscience reports 2018 Dec 21;38(6)
Bioscience reports 2018 Dec 21;38(6)
Epigenetic suppression of E-cadherin expression by Snail2 during the metastasis of colorectal cancer.
Hu Y, Dai M, Zheng Y, Wu J, Yu B, Zhang H, Kong W, Wu H, Yu X
Clinical epigenetics 2018 Dec 12;10(1):154
Clinical epigenetics 2018 Dec 12;10(1):154
RGC-32 regulates reactive astrocytosis and extracellular matrix deposition in experimental autoimmune encephalomyelitis.
Tatomir A, Tegla CA, Martin A, Boodhoo D, Nguyen V, Sugarman AJ, Mekala A, Anselmo F, Talpos-Caia A, Cudrici C, Badea TC, Rus V, Rus H
Immunologic research 2018 Aug;66(4):445-461
Immunologic research 2018 Aug;66(4):445-461
Upregulation of allograft inflammatory factor‑1 expression and secretion by macrophages stimulated with aldosterone promotes renal fibroblasts to a profibrotic phenotype.
Li Y, Wang X, Zhang L, Yuan X, Hao J, Ni J, Hao L
International journal of molecular medicine 2018 Aug;42(2):861-872
International journal of molecular medicine 2018 Aug;42(2):861-872
SNAI1, an endothelial-mesenchymal transition transcription factor, promotes the early phase of ocular neovascularization.
Sun JX, Chang TF, Li MH, Sun LJ, Yan XC, Yang ZY, Liu Y, Xu WQ, Lv Y, Su JB, Liang L, Han H, Dou GR, Wang YS
Angiogenesis 2018 Aug;21(3):635-652
Angiogenesis 2018 Aug;21(3):635-652
Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem.
Han X, Li Y, Xu Y, Zhao X, Zhang Y, Yang X, Wang Y, Zhao R, Anderson GJ, Zhao Y, Nie G
Nature communications 2018 Aug 23;9(1):3390
Nature communications 2018 Aug 23;9(1):3390
LncRNA PTAR promotes EMT and invasion-metastasis in serous ovarian cancer by competitively binding miR-101-3p to regulate ZEB1 expression.
Liang H, Yu T, Han Y, Jiang H, Wang C, You T, Zhao X, Shan H, Yang R, Yang L, Shan H, Gu Y
Molecular cancer 2018 Aug 11;17(1):119
Molecular cancer 2018 Aug 11;17(1):119
Melatonin Protects against Lung Fibrosis by Regulating the Hippo/YAP Pathway.
Zhao X, Sun J, Su W, Shan H, Zhang B, Wang Y, Shabanova A, Shan H, Liang H
International journal of molecular sciences 2018 Apr 9;19(4)
International journal of molecular sciences 2018 Apr 9;19(4)
Novel decellularized liver matrix-alginate hybrid gel beads for the 3D culture of hepatocellular carcinoma cells.
Sun D, Liu Y, Wang H, Deng F, Zhang Y, Zhao S, Ma X, Wu H, Sun G
International journal of biological macromolecules 2018 Apr 1;109:1154-1163
International journal of biological macromolecules 2018 Apr 1;109:1154-1163
Saxagliptin Attenuates Albuminuria by Inhibiting Podocyte Epithelial- to-Mesenchymal Transition via SDF-1α in Diabetic Nephropathy.
Chang YP, Sun B, Han Z, Han F, Hu SL, Li XY, Xue M, Yang Y, Chen L, Li CJ, Chen LM
Frontiers in pharmacology 2017;8:780
Frontiers in pharmacology 2017;8:780
The TGF-β System As a Potential Pathogenic Player in Disease Modulation of Amyotrophic Lateral Sclerosis.
Peters S, Zitzelsperger E, Kuespert S, Iberl S, Heydn R, Johannesen S, Petri S, Aigner L, Thal DR, Hermann A, Weishaupt JH, Bruun TH, Bogdahn U
Frontiers in neurology 2017;8:669
Frontiers in neurology 2017;8:669
Dioscin, a potent ITGA5 inhibitor, reduces the synthesis of collagen against liver fibrosis: Insights from SILAC-based proteomics analysis.
Xu L, Yin L, Tao X, Qi Y, Han X, Xu Y, Song S, Li L, Sun P, Peng J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Sep;107(Pt A):318-328
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Sep;107(Pt A):318-328
Pancreatic cancer-derived exosomes promote tumor metastasis and liver pre-metastatic niche formation.
Yu Z, Zhao S, Ren L, Wang L, Chen Z, Hoffman RM, Zhou J
Oncotarget 2017 Sep 8;8(38):63461-63483
Oncotarget 2017 Sep 8;8(38):63461-63483
MDM2 Contributes to High Glucose-Induced Glomerular Mesangial Cell Proliferation and Extracellular Matrix Accumulation via Notch1.
Lei CT, Tang H, Ye C, You CQ, Zhang J, Zhang CY, Xiong W, Su H, Zhang C
Scientific reports 2017 Sep 4;7(1):10393
Scientific reports 2017 Sep 4;7(1):10393
FZD7 is a novel prognostic marker and promotes tumor metastasis via WNT and EMT signaling pathways in esophageal squamous cell carcinoma.
Cao TT, Xiang D, Liu BL, Huang TX, Tan BB, Zeng CM, Wang ZY, Ming XY, Zhang LY, Jin G, Li F, Wu JL, Guan XY, Lu D, Fu L
Oncotarget 2017 Sep 12;8(39):65957-65968
Oncotarget 2017 Sep 12;8(39):65957-65968
Calreticulin promotes EGF-induced EMT in pancreatic cancer cells via Integrin/EGFR-ERK/MAPK signaling pathway.
Sheng W, Chen C, Dong M, Wang G, Zhou J, Song H, Li Y, Zhang J, Ding S
Cell death & disease 2017 Oct 26;8(10):e3147
Cell death & disease 2017 Oct 26;8(10):e3147
ANGPTL1 Interacts with Integrin α1β1 to Suppress HCC Angiogenesis and Metastasis by Inhibiting JAK2/STAT3 Signaling.
Yan Q, Jiang L, Liu M, Yu D, Zhang Y, Li Y, Fang S, Li Y, Zhu YH, Yuan YF, Guan XY
Cancer research 2017 Nov 1;77(21):5831-5845
Cancer research 2017 Nov 1;77(21):5831-5845
Losartan Attenuates Scar Formation in Filtering Bleb After Trabeculectomy.
Shi H, Wang H, Fu S, Xu K, Zhang X, Xiao Y, Ye W
Investigative ophthalmology & visual science 2017 Mar 1;58(3):1478-1486
Investigative ophthalmology & visual science 2017 Mar 1;58(3):1478-1486
Evodiamine attenuates TGF-β1-induced fibroblast activation and endothelial to mesenchymal transition.
Wu QQ, Xiao Y, Jiang XH, Yuan Y, Yang Z, Chang W, Bian ZY, Tang QZ
Molecular and cellular biochemistry 2017 Jun;430(1-2):81-90
Molecular and cellular biochemistry 2017 Jun;430(1-2):81-90
miR-206 inhibits FN1 expression and proliferation and promotes apoptosis of rat type II alveolar epithelial cells.
Duan J, Zhang X, Zhang S, Hua S, Feng Z
Experimental and therapeutic medicine 2017 Jun;13(6):3203-3208
Experimental and therapeutic medicine 2017 Jun;13(6):3203-3208
NUBPL, a novel metastasis-related gene, promotes colorectal carcinoma cell motility by inducing epithelial-mesenchymal transition.
Wang Y, Wu N, Sun D, Sun H, Tong D, Liu D, Pang B, Li S, Wei J, Dai J, Liu Y, Bai J, Geng J, Fu S, Jin Y
Cancer science 2017 Jun;108(6):1169-1176
Cancer science 2017 Jun;108(6):1169-1176
TGFβ-incurred epigenetic aberrations of miRNA and DNA methyltransferase suppress Klotho and potentiate renal fibrosis.
Yin S, Zhang Q, Yang J, Lin W, Li Y, Chen F, Cao W
Biochimica et biophysica acta. Molecular cell research 2017 Jul;1864(7):1207-1216
Biochimica et biophysica acta. Molecular cell research 2017 Jul;1864(7):1207-1216
Glucose variability aggravates cardiac fibrosis by altering AKT signalling path.
Ying C, Liu T, Ling H, Cheng M, Zhou X, Wang S, Mao Y, Chen L, Zhang R, Li W
Diabetes & vascular disease research 2017 Jul;14(4):327-335
Diabetes & vascular disease research 2017 Jul;14(4):327-335
Autophagy plays a role in FSTL1-induced epithelial mesenchymal transition and airway remodeling in asthma.
Liu T, Liu Y, Miller M, Cao L, Zhao J, Wu J, Wang J, Liu L, Li S, Zou M, Xu J, Broide DH, Dong L
American journal of physiology. Lung cellular and molecular physiology 2017 Jul 1;313(1):L27-L40
American journal of physiology. Lung cellular and molecular physiology 2017 Jul 1;313(1):L27-L40
Rhein reverses Klotho repression via promoter demethylation and protects against kidney and bone injuries in mice with chronic kidney disease.
Zhang Q, Liu L, Lin W, Yin S, Duan A, Liu Z, Cao W
Kidney international 2017 Jan;91(1):144-156
Kidney international 2017 Jan;91(1):144-156
Phosphoinositide 3-kinase/protein kinase B/periostin mediated platelet-derived growth factor-induced cell proliferation and extracellular matrix production in lupus nephritis.
Zhao X, Hao J, Duan H, Rong Z, Li F
Experimental biology and medicine (Maywood, N.J.) 2017 Jan;242(2):160-168
Experimental biology and medicine (Maywood, N.J.) 2017 Jan;242(2):160-168
5-Aza-2'-deoxycytidine induces human Tenon's capsule fibroblasts differentiation and fibrosis by up-regulating TGF-β type I receptor.
Fu S, Sun L, Zhang X, Shi H, Xu K, Xiao Y, Ye W
Experimental eye research 2017 Dec;165:47-58
Experimental eye research 2017 Dec;165:47-58
MicroRNA-139 targets fibronectin 1 to inhibit papillary thyroid carcinoma progression.
Ye Y, Zhuang J, Wang G, He S, Ni J, Xia W
Oncology letters 2017 Dec;14(6):7799-7806
Oncology letters 2017 Dec;14(6):7799-7806
Low molecular weight fucoidan and its fractions inhibit renal epithelial mesenchymal transition induced by TGF-β1 or FGF-2.
Li X, Li X, Zhang Q, Zhao T
International journal of biological macromolecules 2017 Dec;105(Pt 2):1482-1490
International journal of biological macromolecules 2017 Dec;105(Pt 2):1482-1490
CAPE-pNO(2) ameliorated diabetic nephropathy through regulating the Akt/NF-κB/ iNOS pathway in STZ-induced diabetic mice.
Wang X, Li D, Fan L, Xiao Q, Zuo H, Li Z
Oncotarget 2017 Dec 29;8(70):114506-114525
Oncotarget 2017 Dec 29;8(70):114506-114525
Triptolide Restores Autophagy to Alleviate Diabetic Renal Fibrosis through the miR-141-3p/PTEN/Akt/mTOR Pathway.
Li XY, Wang SS, Han Z, Han F, Chang YP, Yang Y, Xue M, Sun B, Chen LM
Molecular therapy. Nucleic acids 2017 Dec 15;9:48-56
Molecular therapy. Nucleic acids 2017 Dec 15;9:48-56
Sesamin prevents apoptosis and inflammation after experimental myocardial infarction by JNK and NF-κB pathways.
Fan D, Yang Z, Yuan Y, Wu QQ, Xu M, Jin YG, Tang QZ
Food & function 2017 Aug 1;8(8):2875-2885
Food & function 2017 Aug 1;8(8):2875-2885
MDM2 mediates fibroblast activation and renal tubulointerstitial fibrosis via a p53-independent pathway.
Ye C, Tang H, Zhao Z, Lei CT, You CQ, Zhang J, Gao P, He FF, Chen S, Wang YM, Zhang C, Su H
American journal of physiology. Renal physiology 2017 Apr 1;312(4):F760-F768
American journal of physiology. Renal physiology 2017 Apr 1;312(4):F760-F768
Naringenin Ameliorated Kidney Injury through Let-7a/TGFBR1 Signaling in Diabetic Nephropathy.
Yan N, Wen L, Peng R, Li H, Liu H, Peng H, Sun Y, Wu T, Chen L, Duan Q, Sun Y, Zhou Q, Wei L, Zhang Z
Journal of diabetes research 2016;2016:8738760
Journal of diabetes research 2016;2016:8738760
Age-Associated Changes in the Vascular Renin-Angiotensin System in Mice.
Yoon HE, Kim EN, Kim MY, Lim JH, Jang IA, Ban TH, Shin SJ, Park CW, Chang YS, Choi BS
Oxidative medicine and cellular longevity 2016;2016:6731093
Oxidative medicine and cellular longevity 2016;2016:6731093
Quantitative Proteomic Profiling the Molecular Signatures of Annexin A5 in Lung Squamous Carcinoma Cells.
Sun B, Bai Y, Zhang L, Gong L, Qi X, Li H, Wang F, Chi X, Jiang Y, Shao S
PloS one 2016;11(9):e0163622
PloS one 2016;11(9):e0163622
Hepatitis B Virus Stimulated Fibronectin Facilitates Viral Maintenance and Replication through Two Distinct Mechanisms.
Ren S, Wang J, Chen TL, Li HY, Wan YS, Peng NF, Gui XE, Zhu Y
PloS one 2016;11(3):e0152721
PloS one 2016;11(3):e0152721
Emodin ameliorates bleomycin-induced pulmonary fibrosis in rats by suppressing epithelial-mesenchymal transition and fibroblast activation.
Guan R, Wang X, Zhao X, Song N, Zhu J, Wang J, Wang J, Xia C, Chen Y, Zhu D, Shen L
Scientific reports 2016 Oct 24;6:35696
Scientific reports 2016 Oct 24;6:35696
MAD2B promotes tubular epithelial-to-mesenchymal transition and renal tubulointerstitial fibrosis via Skp2.
Tang H, Fan D, Lei CT, Ye C, Gao P, Chen S, Meng XF, Su H, Zhang C
Journal of molecular medicine (Berlin, Germany) 2016 Nov;94(11):1297-1307
Journal of molecular medicine (Berlin, Germany) 2016 Nov;94(11):1297-1307
Emodin alleviates bleomycin-induced pulmonary fibrosis in rats.
Guan R, Zhao X, Wang X, Song N, Guo Y, Yan X, Jiang L, Cheng W, Shen L
Toxicology letters 2016 Nov 16;262:161-172
Toxicology letters 2016 Nov 16;262:161-172
Neddylation controls basal MKK7 kinase activity in breast cancer cells.
Zhu T, Wang J, Pei Y, Wang Q, Wu Y, Qiu G, Zhang D, Lv M, Li W, Zhang J
Oncogene 2016 May 19;35(20):2624-33
Oncogene 2016 May 19;35(20):2624-33
Sinomenine activation of Nrf2 signaling prevents hyperactive inflammation and kidney injury in a mouse model of obstructive nephropathy.
Qin T, Du R, Huang F, Yin S, Yang J, Qin S, Cao W
Free radical biology & medicine 2016 Mar;92:90-99
Free radical biology & medicine 2016 Mar;92:90-99
miR-26a suppresses EMT by disrupting the Lin28B/let-7d axis: potential cross-talks among miRNAs in IPF.
Liang H, Liu S, Chen Y, Bai X, Liu L, Dong Y, Hu M, Su X, Chen Y, Huangfu L, Li X, Gu Y, Shan H
Journal of molecular medicine (Berlin, Germany) 2016 Jun;94(6):655-65
Journal of molecular medicine (Berlin, Germany) 2016 Jun;94(6):655-65
Silence of fibronectin 1 increases cisplatin sensitivity of non-small cell lung cancer cell line.
Gao W, Liu Y, Qin R, Liu D, Feng Q
Biochemical and biophysical research communications 2016 Jul 15;476(1):35-41
Biochemical and biophysical research communications 2016 Jul 15;476(1):35-41
Glucocorticoid exposure in early placentation induces preeclampsia in rats via interfering trophoblast development.
Zhang D, Liu H, Zeng J, Miao X, Huang W, Chen H, Huang Y, Li Y, Ye D
General and comparative endocrinology 2016 Jan 1;225:61-70
General and comparative endocrinology 2016 Jan 1;225:61-70
Sinomenine attenuates renal fibrosis through Nrf2-mediated inhibition of oxidative stress and TGFβ signaling.
Qin T, Yin S, Yang J, Zhang Q, Liu Y, Huang F, Cao W
Toxicology and applied pharmacology 2016 Aug 1;304:1-8
Toxicology and applied pharmacology 2016 Aug 1;304:1-8
The anti-fibrotic effects of microRNA-153 by targeting TGFBR-2 in pulmonary fibrosis.
Liang C, Li X, Zhang L, Cui D, Quan X, Yang W
Experimental and molecular pathology 2015 Oct;99(2):279-85
Experimental and molecular pathology 2015 Oct;99(2):279-85
Pediatric Origins of Nephrolithiasis-Associated Atherosclerosis.
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The Journal of pediatrics 2015 Nov;167(5):1074-80.e2
The Journal of pediatrics 2015 Nov;167(5):1074-80.e2
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Oncotarget 2015 Nov 3;6(34):36231-44
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Nutrients 2015 Jun 15;7(6):4829-50
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The Journal of asthma : official journal of the Association for the Care of Asthma 2014 Oct;51(8):863-9
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Investigative ophthalmology & visual science 2014 Nov 18;55(12):8111-22
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PloS one 2013;8(9):e74750
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Toxicology letters 2013 Oct 24;222(2):91-101
Toxicology letters 2013 Oct 24;222(2):91-101
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Proteomics 2012 Jun;12(12):1917-27
Proteomics 2012 Jun;12(12):1917-27
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- NIH/3T3 cells were subjected to SDS PAGE followed by western blot with 15613-1-AP(FN1 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human colon cancer using 15613-1-AP(FN1 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Fibronectin antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Fibronectin. This antibody recognizes human,mouse,rat antigen. The Fibronectin antibody has been validated for the following applications: ELISA, WB, IHC analysis.
