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- Product number
- 15613-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15613-1-AP, RRID:AB_2105691
- Product name
- Fibronectin antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Fibronectin antibody (Cat. #15613-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references PTPLAD1 Regulates PHB-Raf Interaction to Orchestrate Epithelial-Mesenchymal and Mitofusion-Fission Transitions in Colorectal Cancer.
Lysozyme promotes renal fibrosis through the JAK/STAT3 signal pathway in diabetic nephropathy.
Highly Ordered Nanotube-Like Microstructure on Titanium Dental Implant Surface Fabricated via Anodization Enhanced Cell Adhesion and Migration of Human Gingival Fibroblasts.
Bone morphogenetic protein-6 suppresses TGF-β(2)-induced epithelial-mesenchymal transition in retinal pigment epithelium.
MicroRNA-204-5p Ameliorates Renal Injury via Regulating Keap1/Nrf2 Pathway in Diabetic Kidney Disease.
Acute exposure to ultraviolet radiation targets proteins involved in collagen fibrillogenesis.
Quantitative proteomics reveals the protective effects of Yinchenzhufu decoction against cholestatic liver fibrosis in mice by inhibiting the PDGFRβ/PI3K/AKT pathway.
Vitamin D binding protein (VDBP) hijacks twist1 to inhibit vasculogenic mimicry in hepatocellular carcinoma.
ELMO1 ameliorates intestinal epithelial cellular senescence via SIRT1/p65 signaling in inflammatory bowel disease-related fibrosis.
PRM1201 effectively inhibits colorectal cancer metastasis via shaping gut microbiota and short- chain fatty acids.
CircNSD1 promotes cardiac fibrosis through targeting the miR-429-3p/SULF1/Wnt/β-catenin signaling pathway.
CCT6A alleviates pulmonary fibrosis by inhibiting HIF-1α-mediated lactate production.
Gene Profiling of Circular RNAs in Keloid-prone Individuals and ceRNA Network Construction During Wound Healing.
Exposure to micron-grade silica particles triggers pulmonary fibrosis through cell-to-cell delivery of exosomal miR-107.
TGF-β1 inhibitor P144 protects against benign restenosis after esophageal stenting through TGF-β1/Smads signaling pathway inhibition.
Kefir peptides mitigate bleomycin-induced pulmonary fibrosis in mice through modulating oxidative stress, inflammation and gut microbiota.
Pirfenidone alleviates fibrosis by acting on tumour-stroma interplay in pancreatic cancer.
Effects of Nanoparticle-Mediated Dihydromyricetin to Diabetic Wounds: An In Vivo Study.
Generation and application of immortalized sheep fetal fibroblast cell line.
The Rejuvenation and Functional Restoration of Aged Adipose Stem Cells by DUXAP10 Knockdown via the Regulation of the miR-214-3p/RASSF5 Axis.
Remimazolam attenuates inflammation and kidney fibrosis following folic acid injury.
Astaxanthin attenuates cigarette smoke-induced small airway remodeling via the AKT1 signaling pathway.
Wnt5a/β-catenin-mediated epithelial-mesenchymal transition: a key driver of subretinal fibrosis in neovascular age-related macular degeneration.
Nuciferine reduces vascular leakage and improves cardiac function in acute myocardial infarction by regulating the PI3K/AKT pathway.
PDE12 disrupts mitochondrial oxidative phosphorylation and mediates mitochondrial dysfunction to induce oral mucosal epithelial barrier damage in oral submucous fibrosis.
Preventive effects of Ramelteon on bleomycin-induced pulmonary fibrosis in mice.
Kokusaginine attenuates renal fibrosis by inhibiting the PI3K/AKT signaling pathway.
Synergistic effects of photodynamic therapy and chemotherapy: Activating the intrinsic/extrinsic apoptotic pathway of anoikis for triple-negative breast cancer treatment.
Platelet membrane biomimetic nanoparticle-targeted delivery of TGF-β1 siRNA attenuates renal inflammation and fibrosis.
Parkin deficiency promotes liver cancer metastasis by TMEFF1 transcription activation via TGF-β/Smad2/3 pathway.
Long Non-coding RNA ZFAS1 Regulates Fibrosis and Scortosis in the Cell Model of Diabetic Nephropathy Through miR-525-5p/SGK1 Axis.
The histone deacetylase inhibitor MS-275 enhances the matrix mineralization of dental pulp stem cells by inducing fibronectin expression.
Hydrogen Therapy Reverses Cancer-Associated Fibroblasts Phenotypes and Remodels Stromal Microenvironment to Stimulate Systematic Anti-Tumor Immunity.
Icariside II modulates pulmonary fibrosis via PI3K/Akt/β-catenin pathway inhibition of M2 macrophage program.
Cell fusion upregulates PD-L1 expression for evasion from immunosurveillance.
Chitosan-based oral nanoparticles as an efficient platform for kidney-targeted drug delivery in the treatment of renal fibrosis.
Lactate accumulation induced by Akt2-PDK1 signaling promotes pulmonary fibrosis.
In silico prediction and experimental validation to reveal the protective mechanism of Puerarin against excessive extracellular matrix accumulation through inhibiting ferroptosis in diabetic nephropathy.
A cardiotoxicity-eliminated ACE2 variant as a pan-inhibitor against coronavirus cell invasion.
Inhibition of heme oxygenase 1 alleviates thoracic aortic aneurysm via restoration of extracellular matrix.
Rehmannia glutinosa Libosch and Cornus officinalis Sieb herb couple ameliorates renal interstitial fibrosis in CKD rats by inhibiting the TGF-β1/MAPK signaling pathway.
hPMSCs Regulate the Level of TNF-α and IL-10 in Th1 Cells and Improve Hepatic Injury in a GVHD Mouse Model via CD73/ADO/Fyn/Nrf2 Axis.
Microplastics cause hepatotoxicity in diabetic mice by disrupting glucolipid metabolism via PP2A/AMPK/HNF4A and promoting fibrosis via the Wnt/β-catenin pathway.
Alleviative Effect of Lactoferrin Interventions Against the Hepatotoxicity Induced by Titanium Dioxide Nanoparticles.
Targeting ROCK1 in diabetic kidney disease: Unraveling mesangial fibrosis mechanisms and introducing myricetin as a novel antagonist.
Discovery of PRDM16-Mediated TRPA1 Induction as the Mechanism for Low Tubulo-Interstitial Fibrosis in Diabetic Kidney Disease.
Endothelium-specific deletion of p62 causes organ fibrosis and cardiac dysfunction.
Pachymic acid ameliorates bleomycin-induced pulmonary fibrosis through inhibiting endoplasmic reticulum stress in rats.
Lipoamide Attenuates Hypertensive Myocardial Hypertrophy Through PI3K/Akt-Mediated Nrf2 Signaling Pathway.
CD146-dependent macrophage infiltration promotes epidural fibrosis via the Erdr1/ERK/CCR2 pathway.
VDR regulates mitochondrial function as a protective mechanism against renal tubular cell injury in diabetic rats.
BMSC-derived Exosomes Ameliorate Peritoneal Dialysis-associated Peritoneal Fibrosis via the Mir-27a-3p/TP53 Pathway.
Bone morphogenetic protein 6 (BMP6) antagonises experimental proliferative vitreoretinopathy established by TGF-β2 stimulation in retinal pigment epithelial cells through modulation of the p38 and JNK MAPK pathways.
The regulatory role of the apelin/APJ axis in scarring: Identification of upstream and downstream mechanisms.
Therapeutic effects of in vivo administration of an inhibitor of tryptophan 2,3-dioxygenase (680c91) for the treatment of fibroids: a preclinical study.
NBR1-p62-Nrf2 mediates the anti-pulmonary fibrosis effects of protodioscin.
DEC1 is involved in circadian rhythm disruption-exacerbated pulmonary fibrosis.
Jin-Gui-Shen-Qi Wan alleviates fibrosis in mouse diabetic nephropathy via MHC class II.
Favipiravir ameliorates bleomycin-induced pulmonary fibrosis by reprogramming M1/M2 macrophage polarization.
Bioinformatics-based dynamics of cuproptosis -related indicators in experimental silicosis.
Propofol improves ischemia reperfusion-induced liver fibrosis by regulating lncRNA HOXA11-AS.
Up-regulated SPP1 increases the risk from IPF to lung cancer via activating the pro-tumor macrophages.
hucMSC-Ex Alleviates IBD-Associated Intestinal Fibrosis by Inhibiting ERK Phosphorylation in Intestinal Fibroblasts.
FAT10 Silencing Prevents Liver Fibrosis through Regulating SIRT1 Expression in Hepatic Stellate Cells.
Combining Porous Se@SiO(2) Nanocomposites and dECM Enhances the Myogenic Differentiation of Adipose-Derived Stem Cells.
Effects of autophagy inhibitor 3-methyladenine on a diabetic mice model.
Irisin Ameliorates Renal Tubulointerstitial Fibrosis by Regulating the Smad4/β-Catenin Pathway in Diabetic Mice.
CXCL5 knockdown attenuated gemcitabine resistance of pancreatic cancer through regulation of cancer cells and tumour stroma.
Identification and validation of chemokine system-related genes in idiopathic pulmonary fibrosis.
Apolipoprotein A-I attenuates peritoneal fibrosis associated with peritoneal dialysis by inhibiting oxidative stress and inflammation.
Dapagliflozin alleviates renal fibrosis in a mouse model of adenine-induced renal injury by inhibiting TGF-β1/MAPK mediated mitochondrial damage.
Gastrodin attenuates renal injury and collagen deposition via suppression of the TGF-β1/Smad2/3 signaling pathway based on network pharmacology analysis.
EZH2 and matrix co-regulate phenotype and KCNB2 expression in bladder smooth muscle cells.
Differentially expressed genes in orbital adipose/connective tissue of thyroid-associated orbitopathy.
Ferroptosis-dependent breast cancer cell-derived exosomes inhibit migration and invasion of breast cancer cells by suppressing M2 macrophage polarization.
Sclareol attenuates liver fibrosis through SENP1-mediated VEGFR2 SUMOylation and inhibition of downstream STAT3 signaling.
Comparing Effects of Short- and Long-Term Exposure of Cigarette Smoke Extract on Human Vocal Fold Fibroblasts.
Embryo-uterine interaction coordinates mouse embryogenesis during implantation.
Omentin-1 induces mechanically activated fibroblasts lipogenic differentiation through pkm2/yap/pparγ pathway to promote lung fibrosis resolution.
Long non-coding RNA MIDEAS-AS1 inhibits growth and metastasis of triple-negative breast cancer via transcriptionally activating NCALD.
Multi-targeting liposomal codelivery of cisplatin and rapamycin inhibits pancreatic cancer growth and metastasis through stromal modulation.
Fraxin represses NF-κB pathway via inhibiting the activation of epidermal growth factor receptor to ameliorate diabetic renal tubulointerstitial fibrosis.
Targeting STING-mediated pro-inflammatory and pro-fibrotic effects of alveolar macrophages and fibroblasts blunts silicosis caused by silica particles.
Qingda granule ameliorates vascular remodeling and phenotypic transformation of adventitial fibroblasts via suppressing the TGF-β1/Smad2/3 pathway.
MYCT1 attenuates renal fibrosis and tubular injury in diabetic kidney disease.
Nephroprotective Effects of Cardamonin on Renal Ischemia Reperfusion Injury/UUO-Induced Renal Fibrosis.
N-methylpiperazine-diepoxyovatodiolide ameliorates peritoneal fibrosis via suppressing TGF-β/Smad and JAK/STAT signaling pathway.
Ceruloplasmin regulating fibrosis in orbital fibroblasts provides a novel therapeutic target for Graves' orbitopathy.
Pregnane X receptor activation alleviates renal fibrosis in mice via interacting with p53 and inhibiting the Wnt7a/β-catenin signaling.
Nucleosome assembly protein 1 like 1 (NAP1L1) promotes cardiac fibrosis by inhibiting YAP1 ubiquitination and degradation.
Can targeted nanoparticles distinguish cancer metastasis from inflammation?
KCTD4 interacts with CLIC1 to disrupt calcium homeostasis and promote metastasis in esophageal cancer.
Fu-Zheng-Tong-Luo formula promotes autophagy and alleviates idiopathic pulmonary fibrosis by controlling the Janus kinase 2/signal transducer and activator of transcription 3 pathway.
Neuroepithelial cell-transforming 1 promotes cardiac fibrosis via the Wnt/β-catenin signaling pathway.
Proximal Tubular Lats2 Ablation Exacerbates Ischemia/Reperfusion Injury (IRI)-Induced Renal Maladaptive Repair through the Upregulation of P53.
Liraglutide intervention improves high-glucose-induced reactive gliosis of Müller cells and ECM dysregulation.
Mannan-binding lectin ameliorates renal fibrosis by suppressing macrophage-to-myofibroblast transition.
Local administration of liposomal-based Plekhf1 gene therapy attenuates pulmonary fibrosis by modulating macrophage polarization.
Hyperbranched polyamidoamine-RGD peptide/si-circICA1 in the treatment of invasive thyroid cancer through targeting of the miR-486-3p/SERPINA1 axis.
SETD2 deficiency promotes renal fibrosis through the TGF-β/Smad signalling pathway in the absence of VHL.
Melatonin exerts a protective effect in ameliorating nephrolithiasis via targeting AMPK/PINK1-Parkin mediated mitophagy and inhibiting ferroptosis in vivo and in vitro.
Guanxin V alleviates ventricular remodeling by promoting transforming growth factor-beta 1-mediated proteasomal degradation of Vimentin.
Defining the identity and the niches of epithelial stem cells with highly pleiotropic multilineage potency in the human thymus.
Prolonged exposure to the herbicide atrazine promotes kidney fibrosis by activating Wnt/β-catenin signaling in rats.
CircRNA_0017076 acts as a sponge for miR-185-5p in the control of epithelial-to-mesenchymal transition of tubular epithelial cells during renal interstitial fibrosis.
Lysine 2-hydroxyisobutyrylation of NAT10 promotes cancer metastasis in an ac4C-dependent manner.
Nicotine exposure exacerbates silica-induced pulmonary fibrosis via STAT3-BDNF-TrkB-mediated epithelial-mesenchymal transition in alveolar type II cells.
HDAC9-mediated epithelial cell cycle arrest in G2/M contributes to kidney fibrosis in male mice.
Splicing factor YBX1 regulates bone marrow stromal cell fate during aging.
Crosstalk between the JAK2 and TGF-β1 signaling pathways in scleroderma-related interstitial lung disease targeted by baricitinib.
Ginsenoside Rb1 promotes the activation of PPARα pathway via inhibiting FADD to ameliorate heart failure.
USP22 aggravated diabetic renal tubulointerstitial fibrosis progression through deubiquitinating and stabilizing Snail1.
Aristolocholic acid I promotes renal tubular epithelial fibrosis by upregulating matrix metalloproteinase-9 expression via activating the C3a/C3aR axis of macrophages.
PRMT2 promotes RCC tumorigenesis and metastasis via enhancing WNT5A transcriptional expression.
Yishen Tongluo formula alleviates diabetic kidney disease through regulating Sirt6/TGF-β1/Smad2/3 pathway and promoting degradation of TGF-β1.
Interferon regulatory factor 4 deletion protects against kidney inflammation and fibrosis in deoxycorticosterone acetate/salt hypertension.
N4-acetylcytidine modification of lncRNA CTC-490G23.2 promotes cancer metastasis through interacting with PTBP1 to increase CD44 alternative splicing.
Rapid formation of 3D: Decellularized extracellular matrix spheroids for enhancing bone formation.
Cardioprotective and anti-inflammatory effects of Caveolin 1 in experimental diabetic cardiomyopathy.
Sustainably released nanoparticle-based rhynchophylline limits pulmonary fibrosis by inhibiting the TEK-PI3K/AKT signaling pathway.
Combination of pioglitazone, a PPARγ agonist, and synthetic surfactant B-YL prevents hyperoxia-induced lung injury in adult mice lung explants.
ROS promote hyper-methylation of NDRG2 promoters in a DNMTS-dependent manner: Contributes to the progression of renal fibrosis.
GPR97 deficiency ameliorates renal interstitial fibrosis in mouse hypertensive nephropathy.
ZNF133 is a potent suppressor in breast carcinogenesis through dampening L1CAM, a driver for tumor progression.
GYY4137, a H(2)S donor, ameliorates kidney injuries in diabetic mice by modifying renal ROS-associated enzymes.
Mitochondrial folate pathway regulates myofibroblast differentiation and silica-induced pulmonary fibrosis.
AAV9-Tspyl2 gene therapy retards bleomycin-induced pulmonary fibrosis by modulating downstream TGF-β signaling in mice.
GATA zinc finger protein p66β promotes breast cancer cell migration by acting as a co-activator of Snail.
Depletion of CUL4B in macrophages ameliorates diabetic kidney disease via miR-194-5p/ITGA9 axis.
PLAGL2 promotes Snail expression and gastric cancer progression via UCA1/miR-145-5p/YTHDF1 axis.
Therapeutic Effects of Long-Term Administration of Tranilast in an Animal Model for the Treatment of Fibroids.
Genetic lineage tracing reveals stellate cells as contributors to myofibroblasts in pancreas and islet fibrosis.
Total flavonoid extract from Dracocephalum moldavica L. improves pulmonary fibrosis by reducing inflammation and inhibiting the hedgehog signaling pathway.
Dach1 deficiency drives alveolar epithelium apoptosis in pulmonary fibrosis via modulating C-Jun/Bim activity.
Schwann cells regulate tumor cells and cancer-associated fibroblasts in the pancreatic ductal adenocarcinoma microenvironment.
Metformin attenuates chronic lung allograft dysfunction: evidence in rat models.
CXCL17 Attenuates Diesel Exhaust Emissions Exposure-Induced Lung Damage by Regulating Macrophage Function.
Luteolin inhibits subretinal fibrosis and epithelial-mesenchymal transition in laser-induced mouse model via suppression of Smad2/3 and YAP signaling.
Fibronectin promotes tumor angiogenesis and progression of non-small-cell lung cancer by elevating WISP3 expression via FAK/MAPK/ HIF-1α axis and activating wnt signaling pathway.
Single-cell RNA sequencing reveals that HSD17B2 in cancer-associated fibroblasts promotes the development and progression of castration-resistant prostate cancer.
Tartary buckwheat flavonoids alleviates high-fat diet induced kidney fibrosis in mice by inhibiting MAPK and TGF-β1/Smad signaling pathway.
Quercetin inhibits the amphiregulin/EGFR signaling-mediated renal tubular epithelial-mesenchymal transition and renal fibrosis in obstructive nephropathy.
Poly-γ-glutamic acid coating polymeric nanoparticles enhance renal drug distribution and cellular uptake for diabetic nephropathy therapy.
Interference of ALOX5 alleviates inflammation and fibrosis in high glucose‑induced renal mesangial cells.
The aggravate role of exosomal circRNA11:120406118|12040782 on macrophage pyroptosis through miR-30b-5p/NLRP3 axis in silica-induced lung fibrosis.
Effective-compounds of Jinshui Huanxian formula ameliorates fibroblast activation in pulmonary fibrosis by inhibiting the activation of mTOR signaling.
Telocyte-Derived Exosomes Provide an Important Source of Wnts That Inhibits Fibrosis and Supports Regeneration and Repair of Endometrium.
Baicalin prevents fibrosis of human trabecular meshwork cells via inhibiting the MyD88/NF-κB pathway.
Exosomes derived from human adipose mesenchymal stem cells ameliorate hepatic fibrosis by inhibiting PI3K/Akt/mTOR pathway and remodeling choline metabolism.
The miR-103a-3p/TGFBR3 axis regulates TGF-β-induced orbital fibroblast activation and fibrosis in thyroid-eye disease.
A2aR inhibits fibrosis and the EMT process in silicosis by regulating Wnt/β-catenin pathway.
VX-765 attenuates silica-induced lung inflammatory injury and fibrosis by modulating alveolar macrophages pyroptosis in mice.
Extracellular HSP90 promotes differentiation of lens epithelial cells to fiber cells by activating LRP1-YAP-PROX1 axis.
Fyn deficiency inhibits oxidative stress by decreasing c-Cbl-mediated ubiquitination of Sirt1 to attenuate diabetic renal fibrosis.
BMAL1/p53 mediating bronchial epithelial cell autophagy contributes to PM2.5-aggravated asthma.
Macrophage-derived GPNMB trapped by fibrotic extracellular matrix promotes pulmonary fibrosis.
Mitochondrial dysfunction in macrophages promotes inflammation and suppresses repair after myocardial infarction.
Stomatin-like protein 2 deficiency exacerbates adverse cardiac remodeling.
RGS1 mediates renal interstitial fibrosis through activation of the inflammatory response.
DLK1 overexpression improves sepsis-induced cardiac dysfunction and fibrosis in mice through the TGF-β1/Smad3 signaling pathway and MMPs.
Human umbilical cord mesenchymal stem cell exosomes alleviate acute kidney injury by inhibiting pyroptosis in rats and NRK-52E cells.
LncTUG1 ameliorates renal tubular fibrosis in experimental diabetic nephropathy through the miR-145-5p/dual-specificity phosphatase 6 axis.
LncRNA H19-EZH2 interaction promotes liver fibrosis via reprogramming H3K27me3 profiles.
BMAL1 inhibits renal fibrosis and renal interstitial inflammation by targeting the ERK1/2/ELK-1/Egr-1 axis.
Icariside Ⅱ attenuates bleomycin-induced pulmonary fibrosis by modulating macrophage polarization.
TRIOBP modulates β-catenin signaling by regulation of miR-29b in idiopathic pulmonary fibrosis.
Targeting AKT induced Ferroptosis through FTO/YTHDF2-dependent GPX4 m6A methylation up-regulating and degradating in colorectal cancer.
Squalene epoxidase promotes breast cancer progression by regulating CCNB1 protein stability.
Cell and rat serum, urine and tissue metabolomics analysis elucidates the key pathway changes associated with chronic nephropathy and reveals the mechanism of action of rhein.
Aquaporin 1 is a prognostic marker and inhibits tumour progression through downregulation of Snail expression in intrahepatic cholangiocarcinoma.
Testosterone attenuates senile cavernous fibrosis by regulating TGFβR1 and galectin-1 signaling pathways through miR-22-3p.
JMJD3 ablation in myeloid cells confers renoprotection in mice with DOCA/salt-induced hypertension.
Connexin32 Promotes the Activation of Foxo3a to Ameliorate Diabetic Nephropathy via Inhibiting the Polyubiquitination and Degradation of Sirt1.
Neonatal-Tissue-Derived Extracellular Vesicle Therapy (NEXT): A Potent Strategy for Precision Regenerative Medicine.
Crosstalk between Interleukin-1 Receptor-Like 1 and Transforming Growth Factor-β Receptor Signaling Promotes Renal Fibrosis.
USP25 inhibits renal fibrosis by regulating TGFβ-SMAD signaling pathway in Ang II-induced hypertensive mice.
NQO1 alleviates renal fibrosis by inhibiting the TLR4/NF-κB and TGF-β/Smad signaling pathways in diabetic nephropathy.
T Follicular Helper Cells in Tertiary Lymphoid Structure Contribute to Renal Fibrosis by IL-21.
Inhibition of miR-25 Ameliorates Cardiac Dysfunction and Fibrosis by Restoring Krüppel-like Factor 4 Expression.
Biocompatibility and efficacy of prostatic urethral lift in benign prostate hyperplasia: an in vivo and in vitro study.
Knockdown of long noncoding RNA SAN rejuvenates aged adipose-derived stem cells via miR-143-3p/ADD3 axis.
UCP1 alleviates renal interstitial fibrosis progression through oxidative stress pathway mediated by SIRT3 protein stability.
Lenvatinib inhibited HCC cell migration and invasion through regulating the transcription and ubiquitination of UHRF1 and DNMT1.
Qianjin Wenwu decoction suppresses renal interstitial fibrosis by enhancing the degradation of extracellular matrix in mice with unilateral ureteral obstruction.
Characterization of myeloid signature genes for predicting prognosis and immune landscape in Ewing sarcoma.
Two-Pore-Domain Potassium Channel TREK-1 Mediates Pulmonary Fibrosis through Macrophage M2 Polarization and by Direct Promotion of Fibroblast Differentiation.
Neural and central mechanisms of kidney fibrosis after relief of ureteral obstruction.
CEBPD is a master transcriptional factor for hypoxia regulated proteins in glioblastoma and augments hypoxia induced invasion through extracellular matrix-integrin mediated EGFR/PI3K pathway.
FGF18 promotes human lung branching morphogenesis through regulating mesenchymal progenitor cells.
Senescent renal tubular epithelial cells activate fibroblasts by secreting Shh to promote the progression of diabetic kidney disease.
Peroxisome Proliferator-Activated Receptor Gene Knockout Promotes Podocyte Injury in Diabetic Mice.
Blockage of Fibronectin 1 Ameliorates Myocardial Ischemia/Reperfusion Injury in Association with Activation of AMP-LKB1-AMPK Signaling Pathway.
Shenxian-Shengmai Oral Liquid Evoke Autophagy of Fibroblast to Attenuate Sinoatrial Node Fibrosis in Sick Sinus Syndrome Mice via the AKT/mTOR Pathway.
Panax Notoginseng Saponins Regulate Transforming Growth Factor-β1 through MAPK and Snail/TWIST1 Signaling Pathway to Inhibit Epithelial-Mesenchymal Transition of Pulmonary Fibrosis in A549 Cells.
Poly (ADP-ribose) polymerase 1 (PARP1) inhibition promotes pulmonary metastasis of osteosarcoma by boosting ezrin phosphorylation.
NR4A1 inhibits the epithelial-mesenchymal transition of hepatic stellate cells: Involvement of TGF-β-Smad2/3/4-ZEB signaling.
Endoglin aggravates peritoneal fibrosis by regulating the activation of TGF-β/ALK/Smads signaling.
Inhibition of calpain9 attenuates peritoneal dialysis-related peritoneal fibrosis.
Yi-Shen-Hua-Shi Granule Alleviates Adriamycin-Induced Glomerular Fibrosis by Suppressing the BMP2/Smad Signaling Pathway.
ATP-citrate lyase inhibitor improves ectopic lipid accumulation in the kidney in a db/db mouse model.
Fraxin Promotes the Activation of Nrf2/ARE Pathway via Increasing the Expression of Connexin43 to Ameliorate Diabetic Renal Fibrosis.
Gentiopicroside Ameliorates Diabetic Renal Tubulointerstitial Fibrosis via Inhibiting the AT1R/CK2/NF-κB Pathway.
Dihydromyricetin Alleviates Pulmonary Fibrosis by Regulating Abnormal Fibroblasts Through the STAT3/p-STAT3/GLUT1 Signaling Pathway.
Atorvastatin Restores PPARα Inhibition of Lipid Metabolism Disorders by Downregulating miR-21 Expression to Improve Mitochondrial Function and Alleviate Diabetic Nephropathy Progression.
Decreased RNA m(6)A methylation enhances the process of the epithelial mesenchymal transition and vasculogenic mimicry in glioblastoma.
Nintedanib enhances the efficacy of PD-L1 blockade by upregulating MHC-I and PD-L1 expression in tumor cells.
Blockade of phosphotyrosine pathways suggesting SH2 superbinder as a novel therapy for pulmonary fibrosis.
Establishment and characterization of an immortalized epithelial cell line from human gallbladder.
Chordin-Like 1 Regulates Epithelial-to-Mesenchymal Transition and Metastasis via the MAPK Signaling Pathway in Oral Squamous Cell Carcinoma.
ATP11A promotes EMT by regulating Numb PRR(L) in pancreatic cancer cells.
Long Noncoding RNA CTD-2589M5.4 Inhibits Ovarian Cancer Cell Proliferation, Migration, and Invasion Via Downregulation of the Extracellular Matrix-Receptor Interaction Pathway.
Imatinib inhibits pericyte-fibroblast transition and inflammation and promotes axon regeneration by blocking the PDGF-BB/PDGFRβ pathway in spinal cord injury.
PKM2 promotes pulmonary fibrosis by stabilizing TGF-β1 receptor I and enhancing TGF-β1 signaling.
miR-124- and let-7-Mediated Reprogram of Human Fibroblasts into SST Interneurons.
RO4929097, a Selective γ-Secretase Inhibitor, Inhibits Subretinal Fibrosis Via Suppressing Notch and ERK1/2 Signaling in Laser-Induced Mouse Model.
The Apelin-APJ axis alleviates LPS-induced pulmonary fibrosis and endothelial mesenchymal transformation in mice by promoting Angiotensin-Converting Enzyme 2.
HC-1119, a deuterated Enzalutamide, inhibits Migration, Invasion and Metastasis of the AR-positive triple-negative breast Cancer cells.
Anti-inflammatory potential of stevia residue extract against uric acid-associated renal injury in mice.
Sestrin2 attenuates renal damage by regulating Hippo pathway in diabetic nephropathy.
A network pharmacology-based study on the mechanism of astragaloside IV alleviating renal fibrosis through the AKT1/GSK-3β pathway.
Molecular Regulation of Heme Oxygenase-1 Expression by E2F Transcription Factor 2 in Lung Fibroblast Cells: Relevance to Idiopathic Pulmonary Fibrosis.
RNF2 mediates pulmonary fibroblasts activation and proliferation by regulating mTOR and p16-CDK4-Rb1 signaling pathway.
Critical role of PAFR/YAP1 positive feedback loop in cardiac fibrosis.
Endophilin A2 protects against renal fibrosis by targeting TGF-β/Smad signaling.
Apigenin inhibits fibrous scar formation after acute spinal cord injury through TGFβ/SMADs signaling pathway.
Si-Wu-Tang ameliorates bile duct ligation-induced liver fibrosis via modulating immune environment.
Lysophosphatidylcholine acyltransferase 1 alleviates silica-induced pulmonary fibrosis by modulating lipid metabolism.
Blockade of the pentraxin 3/CD44 interaction attenuates lung injury-induced fibrosis.
Intracellular hydroxyproline imprinting following resolution of bleomycin-induced pulmonary fibrosis.
Single-Cell RNA Sequencing Technology Revealed the Pivotal Role of Fibroblast Heterogeneity in Angiotensin II-Induced Abdominal Aortic Aneurysms.
Clusterin as a serum biomarker candidate contributes to the lung fibroblasts activation in chronic obstructive pulmonary disease.
Asiatic acid from Cyclocarya paliurus regulates the autophagy-lysosome system via directly inhibiting TGF-β type I receptor and ameliorates diabetic nephropathy fibrosis.
Reversing insufficient photothermal therapy-induced tumor relapse and metastasis by regulating cancer-associated fibroblasts.
Human epididymis protein 4 aggravates airway inflammation and remodeling in chronic obstructive pulmonary disease.
Drug-eluting intraocular lens with sustained bromfenac release for conquering posterior capsular opacification.
Selenium Deficiency Leads to Changes in Renal Fibrosis Marker Proteins and Wnt/β-Catenin Signaling Pathway Components.
Malfunction of airway basal stem cells plays a crucial role in pathophysiology of tracheobronchopathia osteoplastica.
A rapid and simple procedure for the isolation and cultivation of fibroblast-like cells from medaka and zebrafish embryos and fin clip biopsies.
Atorvastatin reduces IOP in ocular hypertension in vivo and suppresses ECM in trabecular meshwork perhaps via FGD4.
Schwann cell‑like cells derived from human amniotic mesenchymal stem cells promote sciatic nerve repair through an exosome‑induced SOX2/FN1 pathway in vitro.
CHIR99021 balance TGFβ1 induced human corneal endothelial-to-mesenchymal transition to favor corneal endothelial cell proliferation.
IL-33 Promotes ST2-Dependent Fibroblast Maturation via P38 and TGF-β in a Mouse Model of Epidural Fibrosis.
The miRNA-34a/Sirt1/p53 pathway in a rat model of lens regeneration.
Novel Thermosensitive Hydrogel Promotes Spinal Cord Repair by Regulating Mitochondrial Function.
Single-Cell Transcriptomic Analysis of the Mouse Pancreas: Characteristic Features of Pancreatic Ductal Cells in Chronic Pancreatitis.
Systematic analyses identify the anti-fibrotic role of lncRNA TP53TG1 in IPF.
Human amniotic fluid mesenchymal stem cells attenuate pancreatic cancer cell proliferation and tumor growth in an orthotopic xenograft mouse model.
A signature of circadian rhythm genes in driving anaplastic thyroid carcinoma malignant progression.
Gankyrin modulated non-small cell lung cancer progression via glycolysis metabolism in a YAP1-dependent manner.
Reprogramming of Rat Fibroblasts into Induced Neurons by Small-Molecule Compounds In Vitro and In Vivo.
Identification of the active compounds and functional mechanisms of Jinshui Huanxian formula in pulmonary fibrosis by integrating serum pharmacochemistry with network pharmacology.
ZEB2/TWIST1/PRMT5/NuRD Multicomplex Contributes to the Epigenetic Regulation of EMT and Metastasis in Colorectal Carcinoma.
Hexavalent chromium triggers hepatocytes premature senescence via the GATA4/NF-κB signaling pathway mediated by the DNA damage response.
Collagen has a unique SEC24 preference for efficient export from the endoplasmic reticulum.
Doxorubicin promotes breast cancer cell migration and invasion via DCAF13.
AIM2 inflammasome contributes to aldosterone-induced renal injury via endoplasmic reticulum stress.
Identification of Pyruvate Carboxylase as the Cellular Target of Natural Bibenzyls with Potent Anticancer Activity against Hepatocellular Carcinoma via Metabolic Reprogramming.
Overexpression of bone morphogenetic protein receptor type 2 suppresses transforming growth factor β-induced profibrotic responses in lung fibroblasts.
Connexin32 ameliorates epithelial-to-mesenchymal-transition in diabetic renal tubular via inhibiting NOX4.
Norepinephrine promotes glioma cell migration through up-regulating the expression of Twist1.
Numb-PRRL promotes TGF-β1- and EGF-induced epithelial-to-mesenchymal transition in pancreatic cancer.
The HDAC2/SP1/miR-205 feedback loop contributes to tubular epithelial cell extracellular matrix production in diabetic kidney disease.
Necroptosis in pulmonary macrophages promotes silica-induced inflammation and interstitial fibrosis in mice.
Baicalin protects against renal interstitial fibrosis in mice by inhibiting the TGF-β/Smad signalling pathway.
Improving the circulation time and renal therapeutic potency of extracellular vesicles using an endogenous ligand binding strategy.
Carbon dots enhance extracellular matrix secretion for dentin-pulp complex regeneration through PI3K/Akt/mTOR pathway-mediated activation of autophagy.
Astrocyte-derived sEVs alleviate fibrosis and promote functional recovery after spinal cord injury in rats.
Zanubrutinib attenuates bleomycin-induced pulmonary fibrosis by inhibiting the TGF-β1 signaling pathway.
TIPARP is involved in the regulation of intraocular pressure.
Metformin Improves Burn Wound Healing by Modulating Microenvironmental Fibroblasts and Macrophages.
Macrophages regulate vascular smooth muscle cell function during atherosclerosis progression through IL-1β/STAT3 signaling.
Tetramethylpyrazine prevents liver fibrotic injury in mice by targeting hepatocyte-derived and mitochondrial DNA-enriched extracellular vesicles.
Ferrostatin‑1 alleviates oxalate‑induced renal tubular epithelial cell injury, fibrosis and calcium oxalate stone formation by inhibiting ferroptosis.
Krill Oil Turns Off TGF-β1 Profibrotic Signaling in the Prevention of Diabetic Nephropathy.
Tubular epithelial cell-derived extracellular vesicles induce macrophage glycolysis by stabilizing HIF-1α in diabetic kidney disease.
Comparison of Gene Expression Patterns in Articular Cartilage and Xiphoid Cartilage.
Inhibition of RUNX1 blocks the differentiation of lung fibroblasts to myofibroblasts.
Botox-A improve the thyroid-associated ophthalmopathy (TAO) orbital fibroblast activation through inhibiting the TGF-β/Smad signaling.
Exosomes from human adipose-derived mesenchymal stem cells inhibit production of extracellular matrix in keloid fibroblasts via downregulating transforming growth factor-β2 and Notch-1 expression.
Cigarette smoke-induced oxidative stress activates NRF2 to mediate fibronectin disorganization in vascular formation.
SU16f inhibits fibrotic scar formation and facilitates axon regeneration and locomotor function recovery after spinal cord injury by blocking the PDGFRβ pathway.
Hexachlorophene, a selective SHP2 inhibitor, suppresses proliferation and metastasis of KRAS-mutant NSCLC cells by inhibiting RAS/MEK/ERK and PI3K/AKT signaling pathways.
Integrin β3 Induction Promotes Tubular Cell Senescence and Kidney Fibrosis.
Mesenchymal Stem Cells With Cancer-Associated Fibroblast-Like Phenotype Stimulate SDF-1/CXCR4 Axis to Enhance the Growth and Invasion of B-Cell Acute Lymphoblastic Leukemia Cells Through Cell-to-Cell Communication.
Mechanically Activated Calcium Channel PIEZO1 Modulates Radiation-Induced Epithelial-Mesenchymal Transition by Forming a Positive Feedback With TGF-β1.
Tubular cell-derived exosomal miR-150-5p contributes to renal fibrosis following unilateral ischemia-reperfusion injury by activating fibroblast in vitro and in vivo.
NEDD4L-induced β-catenin ubiquitination suppresses the formation and progression of interstitial pulmonary fibrosis via inhibiting the CTHRC1/HIF-1α axis.
Sympathetic Denervation Ameliorates Renal Fibrosis via Inhibition of Cellular Senescence.
Ferulic Acid Ameliorates Hepatic Inflammation and Fibrotic Liver Injury by Inhibiting PTP1B Activity and Subsequent Promoting AMPK Phosphorylation.
The Extracellular Matrix Enriched With Exosomes for the Treatment on Pulmonary Fibrosis in Mice.
Transcriptome-Based Network Analysis Reveals Hirudin Potentiates Anti-Renal Fibrosis Efficacy in UUO Rats.
Berberine Reduces Lipid Accumulation by Promoting Fatty Acid Oxidation in Renal Tubular Epithelial Cells of the Diabetic Kidney.
Mefunidone Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Mice.
Binding of Plasminogen to Streptococcus suis Protein Endopeptidase O Facilitates Evasion of Innate Immunity in Streptococcus suis.
ShenLian Extract Enhances TGF-β Functions in the Macrophage-SMC Unit and Stabilizes Atherosclerotic Plaques.
Ameliorative Effects of Osthole on Experimental Renal Fibrosis in vivo and in vitro by Inhibiting IL-11/ERK1/2 Signaling.
Exosomal miR-500a-5p derived from cancer-associated fibroblasts promotes breast cancer cell proliferation and metastasis through targeting USP28.
Exosomal miR-21 from tubular cells contributes to renal fibrosis by activating fibroblasts via targeting PTEN in obstructed kidneys.
Local administration of liposomal-based Srpx2 gene therapy reverses pulmonary fibrosis by blockading fibroblast-to-myofibroblast transition.
The NEAT1_2/miR-491 Axis Modulates Papillary Thyroid Cancer Invasion and Metastasis Through TGM2/NFκb/FN1 Signaling.
miR-23a-3p regulates the inflammatory response and fibrosis in diabetic kidney disease by targeting early growth response 1.
Use of Platelet-Rich Plasma Plus Suramin, an Antifibrotic Agent, to Improve Muscle Healing After Injuries.
Exercise training ameliorates early diabetic kidney injury by regulating the H(2) S/SIRT1/p53 pathway.
Presegetane diterpenoids from Euphorbia sieboldiana as a new type of anti-liver fibrosis agents that inhibit TGF-β/Smad signaling pathway.
MiR-192-5p inhibits proliferation, migration, and invasion in papillary thyroid carcinoma cells by regulation of SH3RF3.
KLF15 negatively regulates cardiac fibrosis by which SDF-1β attenuates cardiac fibrosis in type 2 diabetic mice.
MIER3 induces epithelial-mesenchymal transition and promotes breast cancer cell aggressiveness via forming a co-repressor complex with HDAC1/HDAC2/Snail.
A novel in vitro assay for peripheral nerve-related cell migration that preserves both extracellular matrix-derived molecular cues and nanofiber-derived topography.
Interleukin-7 Is Associated with Clinical and Pathological Activities in Immunoglobulin A Nephropathy and Protects the Renal Proximal Tubule Epithelium from Cellular Fibrosis.
The long non-coding RNA PFI protects against pulmonary fibrosis by interacting with splicing regulator SRSF1.
Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors.
Triiodothyronine ameliorates silica-induced pulmonary inflammation and fibrosis in mice.
Maiwei Yangfei decoction prevents bleomycin-induced pulmonary fibrosis in mice.
Injectable self-assembling peptide nanofiber hydrogel as a bioactive 3D platform to promote chronic wound tissue regeneration.
Si-Wu-Tang ameliorates fibrotic liver injury via modulating intestinal microbiota and bile acid homeostasis.
Drug-containing serum of rhubarb-astragalus capsule inhibits the epithelial-mesenchymal transformation of HK-2 by downregulating TGF-β1/p38MAPK/Smad2/3 pathway.
MPP7 promotes the migration and invasion of breast cancer cells via EGFR/AKT signaling.
Fibronectin-integrin signaling regulates PLVAP localization at endothelial fenestrae by microtubule stabilization.
miR-509-3p Suppresses Migration, Invasion, and Epithelial- Mesenchymal Transition in Melanoma Cells by Targeting Collagen Triple Helix Repeat Containing 1.
Improved response of human gingival fibroblasts to titanium coated with micro-/nano-structured tantalum.
A HIF1A/miR-485-5p/SRPK1 axis modulates the aggressiveness of glioma cells upon hypoxia.
Glucagon-like peptide-1 (GLP-1) improved diabetic lung fibrosis via AMPK and microRNA-27a (miR-27a).
Dopamine receptor D2 inhibition alleviates diabetic hepatic stellate cells fibrosis by regulating the TGF-β1/Smads and NFκB pathways.
miR‑106b‑5p targeting SIX1 inhibits TGF‑β1‑induced pulmonary fibrosis and epithelial‑mesenchymal transition in asthma through regulation of E2F1.
KLF4 initiates sustained YAP activation to promote renal fibrosis in mice after ischemia-reperfusion kidney injury.
Aptamer-SH2 superbinder-based targeted therapy for pancreatic ductal adenocarcinoma.
pH-Sensitive Nanoparticles Composed Solely of Membrane-Disruptive Macromolecules for Treating Pancreatic Cancer.
The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity.
Identification and functional analysis of senescence-associated secretory phenotype of premature senescent hepatocytes induced by hexavalent chromium.
Regulation of connective tissue growth factor expression by miR-133b for the treatment of renal interstitial fibrosis in aged mice with unilateral ureteral obstruction.
Inhibition of ER stress by targeting the IRE1α-TXNDC5 pathway alleviates crystalline silica-induced pulmonary fibrosis.
USP9X deubiquitinates connexin43 to prevent high glucose-induced epithelial-to-mesenchymal transition in NRK-52E cells.
STAT3/HIF-1α signaling activation mediates peritoneal fibrosis induced by high glucose.
Mesenchymal stem cells ameliorate silica-induced pulmonary fibrosis by inhibition of inflammation and epithelial-mesenchymal transition.
A Novel Rat Model with Long Range Optic Nerve Injury to Study Retinal Ganglion Cells Endogenous Regeneration.
LncRNA CTD-2528L19.6 prevents the progression of IPF by alleviating fibroblast activation.
Pterostilbene alleviates pulmonary fibrosis by regulating ASIC2.
GALNT2 promotes cell proliferation, migration, and invasion by activating the Notch/Hes1-PTEN-PI3K/Akt signaling pathway in lung adenocarcinoma.
Physcion 8-O-β-glucopyranoside ameliorates liver fibrosis through inflammation inhibition by regulating SIRT3-mediated NF-κB P65 nuclear expression.
Long noncoding RNA EPB41L4A-AS1 functions as an oncogene by regulating the Rho/ROCK pathway in colorectal cancer.
Treatment of keloids through Runx2 siRNA‑induced inhibition of the PI3K/AKT signaling pathway.
Mitomycin C induces pulmonary vascular endothelial-to-mesenchymal transition and pulmonary veno-occlusive disease via Smad3-dependent pathway in rats.
Responsive and activable nanomedicines for remodeling the tumor microenvironment.
Anti-renal interstitial fibrosis effect of norcantharidin is exerted through inhibition of PP2Ac-mediated C-terminal phosphorylation of Smad3.
Involvement of miR-27a-3p in diabetic nephropathy via affecting renal fibrosis, mitochondrial dysfunction, and endoplasmic reticulum stress.
Epigallocatechin gallate (EGCG) attenuates myocardial hypertrophy and fibrosis induced by transverse aortic constriction via inhibiting the Akt/mTOR pathway.
Exosomal ANXA2 derived from ovarian cancer cells regulates epithelial-mesenchymal plasticity of human peritoneal mesothelial cells.
Tissue factor potentiates adherence of breast cancer cells to human umbilical vein endothelial cells under static and flow conditions.
Withaferin A protects against hyperuricemia induced kidney injury and its possible mechanisms.
Deficiency of CARMA3 attenuates the development of bleomycin induced pulmonary fibrosis.
Effects of L-leucine on the properties of spray-dried swellable microparticles with wrinkled surfaces for inhalation therapy of pulmonary fibrosis.
Heat shock protein 90 inhibitor ameliorates pancreatic fibrosis by degradation of transforming growth factor-β receptor.
LncRNA-MALAT1/miRNA-204-5p/Smad4 Axis Regulates Epithelial-Mesenchymal Transition, Proliferation and Migration of Lens Epithelial Cells.
IL-1β augments TGF-β inducing epithelial-mesenchymal transition of epithelial cells and associates with poor pulmonary function improvement in neutrophilic asthmatics.
Adenosine A3 receptor activated in H(2)O(2) oxidative stress of primary open-angle glaucoma.
Metformin attenuates post-epidural fibrosis by inhibiting the TGF-β1/Smad3 and HMGB1/TLR4 signaling pathways.
Astragalus membranaceus and Salvia miltiorrhiza ameliorates cyclosporin A-induced chronic nephrotoxicity through the "gut-kidney axis".
Metformin effectively treats Tsc1 deletion-caused kidney pathology by upregulating AMPK phosphorylation.
IL-33-induced neutrophil extracellular traps degrade fibronectin in a murine model of bronchopulmonary dysplasia.
Transcriptomic Analysis Reveals the Protection of Astragaloside IV against Diabetic Nephropathy by Modulating Inflammation.
Hirudin Ameliorates Renal Interstitial Fibrosis via Regulating TGF-β1/Smad and NF-κB Signaling in UUO Rat Model.
Withaferin A Exerts Preventive Effect on Liver Fibrosis through Oxidative Stress Inhibition in a Sirtuin 3-Dependent Manner.
Empagliflozin Protects Against Proximal Renal Tubular Cell Injury Induced by High Glucose via Regulation of Hypoxia-Inducible Factor 1-Alpha.
Melatonin ameliorates hyperglycaemia-induced renal inflammation by inhibiting the activation of TLR4 and TGF-β1/Smad3 signalling pathway.
Hyperoside Attenuates Bleomycin-Induced Pulmonary Fibrosis Development in Mice.
Scutellarein inhibits BLM-mediated pulmonary fibrosis by affecting fibroblast differentiation, proliferation, and apoptosis.
Epithelial-Mesenchymal Transition in Asthma Airway Remodeling Is Regulated by the IL-33/CD146 Axis.
Andrographolide attenuates epithelial-mesenchymal transition induced by TGF-β1 in alveolar epithelial cells.
Deubiquitinase USP13 promotes extracellular matrix expression by stabilizing Smad4 in lung fibroblast cells.
The AKT/GSK3-Mediated Slug Expression Contributes to Oxaliplatin Resistance in Colorectal Cancer via Upregulation of ERCC1.
Deubiquitinase USP29 promotes gastric cancer cell migration by cooperating with phosphatase SCP1 to stabilize Snail protein.
Neutrophil extracellular traps promote scar formation in post-epidural fibrosis.
MAD2B contributes to parietal epithelial cell activation and crescentic glomerulonephritis via Skp2.
MiR-185-5p ameliorates endoplasmic reticulum stress and renal fibrosis by downregulation of ATF6.
Sox13 promotes hepatocellular carcinoma metastasis by transcriptionally activating Twist1.
TREM2 Alzheimer's variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages.
Norcantharidin protects against renal interstitial fibrosis by suppressing TWEAK-mediated Smad3 phosphorylation.
Ganoderic acid hinders renal fibrosis via suppressing the TGF-β/Smad and MAPK signaling pathways.
Inhibition of miR-182-5p attenuates pulmonary fibrosis via TGF-β/Smad pathway.
Ischemia-reperfusion injury of brain induces endothelial-mesenchymal transition and vascular fibrosis via activating let-7i/TGF-βR1 double-negative feedback loop.
Cardamonin retards progression of autosomal dominant polycystic kidney disease via inhibiting renal cyst growth and interstitial fibrosis.
High-mobility group box 1 promotes epithelial-to-mesenchymal transition in crystalline silica induced pulmonary inflammation and fibrosis.
IRF-1 promotes renal fibrosis by downregulation of Klotho.
WNT1-inducible signaling protein-1 mediates TGF-β1-induced renal fibrosis in tubular epithelial cells and unilateral ureteral obstruction mouse models via autophagy.
A PTAL-miR-101-FN1 Axis Promotes EMT and Invasion-Metastasis in Serous Ovarian Cancer.
Tartrate-Resistant Acid Phosphatase 5/ACP5 Interacts with p53 to Control the Expression of SMAD3 in Lung Adenocarcinoma.
Monocyte-derived alveolar macrophage apolipoprotein E participates in pulmonary fibrosis resolution.
Antisense Oligonucleotide in LNA-Gapmer Design Targeting TGFBR2-A Key Single Gene Target for Safe and Effective Inhibition of TGFβ Signaling.
Long non-coding RNA DBH-AS1 promotes cancer progression in diffuse large B-cell lymphoma by targeting FN1 via RNA-binding protein BUD13.
HMGB1 protein promotes glomerular mesangial matrix deposition via TLR2 in lupus nephritis.
RhoJ Regulates α5β1 Integrin Trafficking to Control Fibronectin Remodeling during Angiogenesis.
Transcriptomic analysis of the mechanisms of alleviating renal interstitial fibrosis using the traditional Chinese medicine Kangxianling in a rat model.
Klotho is regulated by transcription factor Sp1 in renal tubular epithelial cells.
Modification of PLGA Scaffold by MSC-Derived Extracellular Matrix Combats Macrophage Inflammation to Initiate Bone Regeneration via TGF-β-Induced Protein.
LRIG3 represses cell motility by inhibiting slug via inactivating ERK signaling in human colorectal cancer.
The effect of lncRNA-ARAP1-AS2/ARAP1 on high glucose-induced cytoskeleton rearrangement and epithelial-mesenchymal transition in human renal tubular epithelial cells.
Connexin 43 prevents the progression of diabetic renal tubulointerstitial fibrosis by regulating the SIRT1-HIF-1α signaling pathway.
Type I collagen facilitates safe and reliable expansion of human dental pulp stem cells in xenogeneic serum-free culture.
Phloretin ameliorates hyperuricemia-induced chronic renal dysfunction through inhibiting NLRP3 inflammasome and uric acid reabsorption.
miRNA‑342 suppresses renal interstitial fibrosis in diabetic nephropathy by targeting SOX6.
Subcellular trafficking of tubular MDM2 implicates in acute kidney injury to chronic kidney disease transition during multiple low-dose cisplatin exposure.
Hydrogen sulfide attenuates cigarette smoke-induced airway remodeling by upregulating SIRT1 signaling pathway.
Celastrol exerts anti-inflammatory effect in liver fibrosis via activation of AMPK-SIRT3 signalling.
Connexin32 ameliorates renal fibrosis in diabetic mice by promoting K48-linked NADPH oxidase 4 polyubiquitination and degradation.
Gentiopicroside activates the bile acid receptor Gpbar1 (TGR5) to repress NF-kappaB pathway and ameliorate diabetic nephropathy.
Long non-coding RNA RNF7 promotes the cardiac fibrosis in rat model via miR-543/THBS1 axis and TGFβ1 activation.
GSPE alleviates renal fibrosis by inhibiting the activation of C3/ HMGB1/ TGF-β1 pathway.
miR-485 suppresses inflammation and proliferation of mesangial cells in an in vitro model of diabetic nephropathy by targeting NOX5.
Fibroblasts Derived From Human Adipose Stem Cells Produce More Effective Extracellular Matrix and Migrate Faster Compared to Primary Dermal Fibroblasts.
miR-363-3p inhibits migration, invasion, and epithelial-mesenchymal transition by targeting NEDD9 and SOX4 in non-small-cell lung cancer.
Anti-Adhesive, Platelet Gathering Effects of c-RGD Modified Poly(p-dioxanone-co-l-Phe) Electrospun Membrane and Its Comprehensive Application in Intestinal Anastomosis.
A self-assembling peptide hydrogel-based drug co-delivery platform to improve tissue repair after ischemia-reperfusion injury.
IL-6 trans-signaling drives a STAT3-dependent pathway that leads to structural alterations of the peritoneal membrane.
Polydatin attenuates renal fibrosis in diabetic mice through regulating the Cx32-Nox4 signaling pathway.
Disruption of retinoid homeostasis induces RBP4 overproduction in diabetes: O-GlcNAcylation involved.
Stem-cell-derived ECM sheet-implant complexes for enhancing osseointegration.
Regulation of FN1 degradation by the p62/SQSTM1-dependent autophagy-lysosome pathway in HNSCC.
Transcriptome analysis reveals a protective role of liver X receptor alpha against silica particle-induced experimental silicosis.
Metformin inhibits extracellular matrix accumulation, inflammation and proliferation of mesangial cells in diabetic nephropathy by regulating H19/miR-143-3p/TGF-β1 axis.
Melatonin Ameliorates Renal Fibrosis Through the Inhibition of NF-κB and TGF-β1/Smad3 Pathways in db/db Diabetic Mice.
Possible involvement of TGF‑β‑SMAD‑mediated epithelial‑mesenchymal transition in pro‑metastatic property of PAX6.
miR-143 inhibits renal cell carcinoma cells metastatic potential by suppressing ABL2.
Hsa-miR-425-5p promotes tumor growth and metastasis by activating the CTNND1-mediated β-catenin pathway and EMT in colorectal cancer.
Trichostatin A Alleviates Renal Interstitial Fibrosis Through Modulation of the M2 Macrophage Subpopulation.
RIG-I aggravates interstitial fibrosis via c-Myc-mediated fibroblast activation in UUO mice.
LncRNA LINP1 confers tamoxifen resistance and negatively regulated by ER signaling in breast cancer.
Micro-vesicles from mesenchymal stem cells over-expressing miR-34a inhibit transforming growth factor-β1-induced epithelial-mesenchymal transition in renal tubular epithelial cells in vitro.
Wu-Mei-Wan ameliorates chronic colitis-associated intestinal fibrosis through inhibiting fibroblast activation.
MicroRNA-183 regulates lipopolysaccharide-induced oxidative stress of hippocampal neurons by targeting the fibronectin 1 gene.
Exosomal miR-125a-5p derived from silica-exposed macrophages induces fibroblast transdifferentiation.
Kidney-targeted rhein-loaded liponanoparticles for diabetic nephropathy therapy via size control and enhancement of renal cellular uptake.
FOXO1 Overexpression Attenuates Tubulointerstitial Fibrosis and Apoptosis in Diabetic Kidneys by Ameliorating Oxidative Injury via TXNIP-TRX.
Stem Cells from Human Exfoliated Deciduous Teeth Ameliorate Diabetic Nephropathy In Vivo and In Vitro by Inhibiting Advanced Glycation End Product-Activated Epithelial-Mesenchymal Transition.
TGF-β1 Induces Epithelial-Mesenchymal Transition of Chronic Sinusitis with Nasal Polyps through MicroRNA-21.
Presence and function of stress granules in atrial fibrillation.
Development and validation of a novel phonomimetic bioreactor.
CLK3 Is A Direct Target Of miR-144 And Contributes To Aggressive Progression In Hepatocellular Carcinoma.
Ursolic Acid Treatment Alleviates Diabetic Kidney Injury By Regulating The ARAP1/AT1R Signaling Pathway.
A small molecule inhibitor MCC950 ameliorates kidney injury in diabetic nephropathy by inhibiting NLRP3 inflammasome activation.
Low-molecular-weight fucoidan attenuates bleomycin-induced pulmonary fibrosis: possible role in inhibiting TGF-β1-induced epithelial-mesenchymal transition through ERK pathway.
Dapagliflozin Attenuates Renal Tubulointerstitial Fibrosis Associated With Type 1 Diabetes by Regulating STAT1/TGFβ1 Signaling.
lncRNA NR_038323 Suppresses Renal Fibrosis in Diabetic Nephropathy by Targeting the miR-324-3p/DUSP1 Axis.
Germacrane Sesquiterpenoids as a New Type of Anticardiac Fibrosis Agent Targeting Transforming Growth Factor β Type I Receptor.
Plasma fractalkine levels are associated with renal inflammation and outcomes in immunoglobulin A nephropathy.
Pioglitazone attenuates kidney fibrosis via miR-21-5p modulation.
Potential role of M2 macrophage polarization in ventilator-induced lung fibrosis.
FoxO1-mediated inhibition of STAT1 alleviates tubulointerstitial fibrosis and tubule apoptosis in diabetic kidney disease.
TNF-α Regulates ITGβ1 and SYND4 Expression in Nucleus Pulposus Cells: Activation of FAK/PI3K Signaling.
RNA-Seq analysis of potential lncRNAs and genes for the anti-renal fibrotic effect of norcantharidin.
Rhodojaponin II attenuates kidney injury by regulating TGF-β1/Smad pathway in mice with adriamycin nephropathy.
NLRP3 inflammasome inhibition attenuates cisplatin-induced renal fibrosis by decreasing oxidative stress and inflammation.
Genetic loss of Gas6/Mer pathway attenuates silica-induced lung inflammation and fibrosis in mice.
Role of CCR2 in the Development of Streptozotocin-Treated Diabetic Cardiomyopathy.
G9a and histone deacetylases are crucial for Snail2-mediated E-cadherin repression and metastasis in hepatocellular carcinoma.
ROCK2 Confers Acquired Gemcitabine Resistance in Pancreatic Cancer Cells by Upregulating Transcription Factor ZEB1.
Olfactory ensheathing cells facilitate neurite sprouting and outgrowth by secreting high levels of hevin.
HIC-5 in cancer-associated fibroblasts contributes to esophageal squamous cell carcinoma progression.
SREBP1, targeted by miR-18a-5p, modulates epithelial-mesenchymal transition in breast cancer via forming a co-repressor complex with Snail and HDAC1/2.
MicroRNA-34a Promotes Renal Fibrosis by Downregulation of Klotho in Tubular Epithelial Cells.
Inhibition of lymphatic proliferation by the selective VEGFR-3 inhibitor SAR131675 ameliorates diabetic nephropathy in db/db mice.
Intervertebral disc regeneration with an adipose mesenchymal stem cell-derived tissue-engineered construct in a rat nucleotomy model.
Ribes diacanthum Pall (RDP) ameliorates UUO-induced renal fibrosis via both canonical and non-canonical TGF-β signaling pathways in mice.
Three kinds of corneal host cells contribute differently to corneal neovascularization.
EZH2-DNMT1-mediated epigenetic silencing of miR-142-3p promotes metastasis through targeting ZEB2 in nasopharyngeal carcinoma.
RNF128 Promotes Invasion and Metastasis Via the EGFR/MAPK/MMP-2 Pathway in Esophageal Squamous Cell Carcinoma.
Role of PM(2.5) in the development and progression of COPD and its mechanisms.
Aspirin inhibits inflammation and scar formation in the injury tendon healing through regulating JNK/STAT-3 signalling pathway.
LncRNA PFAR contributes to fibrogenesis in lung fibroblasts through competitively binding to miR-15a.
Sphingosine kinase 1 promotes the metastasis of colorectal cancer by inducing the epithelial‑mesenchymal transition mediated by the FAK/AKT/MMPs axis.
Loss of TMEM126A promotes extracellular matrix remodeling, epithelial-to-mesenchymal transition, and breast cancer metastasis by regulating mitochondrial retrograde signaling.
miR-196a-5p promotes metastasis of colorectal cancer via targeting IκBα.
Tinagl1 Suppresses Triple-Negative Breast Cancer Progression and Metastasis by Simultaneously Inhibiting Integrin/FAK and EGFR Signaling.
Protein kinase C inhibitor chelerythrine attenuates partial unilateral ureteral obstruction induced kidney injury in neonatal rats.
An improved cellular enucleation method with extracellular matrix and colchicine facilitates the study of nucleocytoplasmic interaction.
Snail2 induced E-cadherin suppression and metastasis in lung carcinoma facilitated by G9a and HDACs.
Injectable extracellular vesicle-released self-assembling peptide nanofiber hydrogel as an enhanced cell-free therapy for tissue regeneration.
Functional significance of U2AF1 S34F mutations in lung adenocarcinomas.
MicroRNA-432 is downregulated in cervical cancer and directly targets FN1 to inhibit cell proliferation and invasion.
TGF-β-mediated upregulation of brachyury contributes to constitutively up-regulated type I collagen expression in skin fibroblasts: possible role in systemic sclerosis.
Astaxanthin ameliorates renal interstitial fibrosis and peritubular capillary rarefaction in unilateral ureteral obstruction.
Effects of SIRT1 silencing on viability, invasion and metastasis of human glioma cell lines.
Citrus alkaline extracts prevent fibroblast senescence to ameliorate pulmonary fibrosis via activation of COX-2.
LncRNA PFL contributes to cardiac fibrosis by acting as a competing endogenous RNA of let-7d.
Inhibition of SIRT2 Alleviates Fibroblast Activation and Renal Tubulointerstitial Fibrosis via MDM2.
Kindlin-2 regulates hepatic stellate cells activation and liver fibrogenesis.
Cyclin G2 Suppresses Glomerulosclerosis by Regulating Canonical Wnt Signalling.
Kidney-targeted drug delivery via rhein-loaded polyethyleneglycol-co-polycaprolactone-co-polyethylenimine nanoparticles for diabetic nephropathy therapy.
Wenyang Huazhuo Tongluo formula inhibits fibrosis via suppressing Wnt/β-catenin signaling pathway in a Bleomycin-induced systemic sclerosis mouse model.
Renal-protective effect of thalidomide in streptozotocin-induced diabetic rats through anti-inflammatory pathway.
LncRNA UCA1 sponges miR-204-5p to promote migration, invasion and epithelial-mesenchymal transition of glioma cells via upregulation of ZEB1.
A novel bioscaffold with naturally-occurring extracellular matrix promotes hepatocyte survival and vessel patency in mouse models of heterologous transplantation.
lncRNA PFAR Promotes Lung Fibroblast Activation and Fibrosis by Targeting miR-138 to Regulate the YAP1-Twist Axis.
S3I-201 ameliorates tubulointerstitial lesion of the kidneys in MRL/lpr mice.
NMDA receptor activation inhibits the antifibrotic effect of BM-MSCs on bleomycin-induced pulmonary fibrosis.
lncRNA PFAL promotes lung fibrosis through CTGF by competitively binding miR-18a.
Inhibition of lncRNA PFRL prevents pulmonary fibrosis by disrupting the miR-26a/smad2 loop.
The pro-metastasis effect of circANKS1B in breast cancer.
Effects of Resveratrol on the Renin-Angiotensin System in the Aging Kidney.
Towards an in vitro fibrogenesis model of human vocal fold scarring.
Methanol fixed fibroblasts serve as feeder cells to maintain stem cells in the pluripotent state in vitro.
Rotenone ameliorates chronic renal injury caused by acute ischemia/reperfusion.
Fibronectin Facilitates Enterovirus 71 Infection by Mediating Viral Entry.
LincRNA 1700020I14Rik alleviates cell proliferation and fibrosis in diabetic nephropathy via miR-34a-5p/Sirt1/HIF-1α signaling.
The protective effect of resveratrol on vascular aging by modulation of the renin-angiotensin system.
RhoA/Rho-kinase triggers epithelial-mesenchymal transition in mesothelial cells and contributes to the pathogenesis of dialysis-related peritoneal fibrosis.
Autophagy inhibition attenuates the induction of anti-inflammatory effect of catalpol in liver fibrosis.
Administration of cytokine-induced myeloid-derived suppressor cells ameliorates renal fibrosis in diabetic mice.
Stachydrine ameliorates carbon tetrachloride-induced hepatic fibrosis by inhibiting inflammation, oxidative stress and regulating MMPs/TIMPs system in rats.
β-Arrestin-1 deficiency ameliorates renal interstitial fibrosis by blocking Wnt1/β-catenin signaling in mice.
Aucubin Protects against TGFβ1-Induced Cardiac Fibroblasts Activation by Mediating the AMPKα/mTOR Signaling Pathway.
Regulation of pancreatic stellate cell activation by Notch3.
PLZF inhibits proliferation and metastasis of gallbladder cancer by regulating IFIT2.
SIRT3 prevents angiotensin II-induced renal tubular epithelial-mesenchymal transition by ameliorating oxidative stress and mitochondrial dysfunction.
Salvianolic acid B inhibits myofibroblast transdifferentiation in experimental pulmonary fibrosis via the up-regulation of Nrf2.
Nicotine Induces Progressive Properties of Lung Adenocarcinoma A549 Cells by Inhibiting Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Expression and Plasma Membrane Localization.
Autophagy promotes fibrosis and apoptosis in the peritoneum during long-term peritoneal dialysis.
Ursolic Acid Attenuates High Glucose-Mediated Mesangial Cell Injury by Inhibiting the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR) Signaling Pathway.
A cell culture condition that induces the mesenchymal-epithelial transition of dedifferentiated porcine retinal pigment epithelial cells.
CAPE-pNO(2) attenuates diabetic cardiomyopathy through the NOX4/NF-κB pathway in STZ-induced diabetic mice.
Binding of a glaucoma-associated myocilin variant to the αB-crystallin chaperone impedes protein clearance in trabecular meshwork cells.
Tamoxifen attenuates dialysate-induced peritoneal fibrosis by inhibiting GSK-3β/β-catenin axis activation.
Epigenetic suppression of E-cadherin expression by Snail2 during the metastasis of colorectal cancer.
RGC-32 regulates reactive astrocytosis and extracellular matrix deposition in experimental autoimmune encephalomyelitis.
Upregulation of allograft inflammatory factor‑1 expression and secretion by macrophages stimulated with aldosterone promotes renal fibroblasts to a profibrotic phenotype.
SNAI1, an endothelial-mesenchymal transition transcription factor, promotes the early phase of ocular neovascularization.
Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem.
LncRNA PTAR promotes EMT and invasion-metastasis in serous ovarian cancer by competitively binding miR-101-3p to regulate ZEB1 expression.
Melatonin Protects against Lung Fibrosis by Regulating the Hippo/YAP Pathway.
Novel decellularized liver matrix-alginate hybrid gel beads for the 3D culture of hepatocellular carcinoma cells.
Saxagliptin Attenuates Albuminuria by Inhibiting Podocyte Epithelial- to-Mesenchymal Transition via SDF-1α in Diabetic Nephropathy.
The TGF-β System As a Potential Pathogenic Player in Disease Modulation of Amyotrophic Lateral Sclerosis.
Dioscin, a potent ITGA5 inhibitor, reduces the synthesis of collagen against liver fibrosis: Insights from SILAC-based proteomics analysis.
Pancreatic cancer-derived exosomes promote tumor metastasis and liver pre-metastatic niche formation.
MDM2 Contributes to High Glucose-Induced Glomerular Mesangial Cell Proliferation and Extracellular Matrix Accumulation via Notch1.
FZD7 is a novel prognostic marker and promotes tumor metastasis via WNT and EMT signaling pathways in esophageal squamous cell carcinoma.
Calreticulin promotes EGF-induced EMT in pancreatic cancer cells via Integrin/EGFR-ERK/MAPK signaling pathway.
ANGPTL1 Interacts with Integrin α1β1 to Suppress HCC Angiogenesis and Metastasis by Inhibiting JAK2/STAT3 Signaling.
Losartan Attenuates Scar Formation in Filtering Bleb After Trabeculectomy.
Evodiamine attenuates TGF-β1-induced fibroblast activation and endothelial to mesenchymal transition.
miR-206 inhibits FN1 expression and proliferation and promotes apoptosis of rat type II alveolar epithelial cells.
NUBPL, a novel metastasis-related gene, promotes colorectal carcinoma cell motility by inducing epithelial-mesenchymal transition.
TGFβ-incurred epigenetic aberrations of miRNA and DNA methyltransferase suppress Klotho and potentiate renal fibrosis.
Glucose variability aggravates cardiac fibrosis by altering AKT signalling path.
Autophagy plays a role in FSTL1-induced epithelial mesenchymal transition and airway remodeling in asthma.
Rhein reverses Klotho repression via promoter demethylation and protects against kidney and bone injuries in mice with chronic kidney disease.
Phosphoinositide 3-kinase/protein kinase B/periostin mediated platelet-derived growth factor-induced cell proliferation and extracellular matrix production in lupus nephritis.
5-Aza-2'-deoxycytidine induces human Tenon's capsule fibroblasts differentiation and fibrosis by up-regulating TGF-β type I receptor.
MicroRNA-139 targets fibronectin 1 to inhibit papillary thyroid carcinoma progression.
Low molecular weight fucoidan and its fractions inhibit renal epithelial mesenchymal transition induced by TGF-β1 or FGF-2.
CAPE-pNO(2) ameliorated diabetic nephropathy through regulating the Akt/NF-κB/ iNOS pathway in STZ-induced diabetic mice.
Triptolide Restores Autophagy to Alleviate Diabetic Renal Fibrosis through the miR-141-3p/PTEN/Akt/mTOR Pathway.
Sesamin prevents apoptosis and inflammation after experimental myocardial infarction by JNK and NF-κB pathways.
MDM2 mediates fibroblast activation and renal tubulointerstitial fibrosis via a p53-independent pathway.
Naringenin Ameliorated Kidney Injury through Let-7a/TGFBR1 Signaling in Diabetic Nephropathy.
Age-Associated Changes in the Vascular Renin-Angiotensin System in Mice.
Quantitative Proteomic Profiling the Molecular Signatures of Annexin A5 in Lung Squamous Carcinoma Cells.
Hepatitis B Virus Stimulated Fibronectin Facilitates Viral Maintenance and Replication through Two Distinct Mechanisms.
Emodin ameliorates bleomycin-induced pulmonary fibrosis in rats by suppressing epithelial-mesenchymal transition and fibroblast activation.
MAD2B promotes tubular epithelial-to-mesenchymal transition and renal tubulointerstitial fibrosis via Skp2.
Emodin alleviates bleomycin-induced pulmonary fibrosis in rats.
Sinomenine activation of Nrf2 signaling prevents hyperactive inflammation and kidney injury in a mouse model of obstructive nephropathy.
miR-26a suppresses EMT by disrupting the Lin28B/let-7d axis: potential cross-talks among miRNAs in IPF.
Silence of fibronectin 1 increases cisplatin sensitivity of non-small cell lung cancer cell line.
Glucocorticoid exposure in early placentation induces preeclampsia in rats via interfering trophoblast development.
Sinomenine attenuates renal fibrosis through Nrf2-mediated inhibition of oxidative stress and TGFβ signaling.
The anti-fibrotic effects of microRNA-153 by targeting TGFBR-2 in pulmonary fibrosis.
Pediatric Origins of Nephrolithiasis-Associated Atherosclerosis.
MiR-25 promotes hepatocellular carcinoma cell growth, migration and invasion by inhibiting RhoGDI1.
Protective Effect of the Total Saponins from Rosa laevigata Michx Fruit against Carbon Tetrachloride-Induced Liver Fibrosis in Rats.
IL-33 promotes airway remodeling and is a marker of asthma disease severity.
Benzalkonium chloride induces subconjunctival fibrosis through the COX-2-modulated activation of a TGF-β1/Smad3 signaling pathway.
miR-203 inhibits tumor cell migration and invasion via caveolin-1 in pancreatic cancer cells.
miR-483-5p promotes invasion and metastasis of lung adenocarcinoma by targeting RhoGDI1 and ALCAM.
Reduction of microRNA-206 contributes to the development of bronchopulmonary dysplasia through up-regulation of fibronectin 1.
Brucine, an alkaloid from seeds of Strychnos nux-vomica Linn., represses hepatocellular carcinoma cell migration and metastasis: the role of hypoxia inducible factor 1 pathway.
Global profiling of proteolytically modified proteins in human metastatic hepatocellular carcinoma cell lines reveals CAPN2 centered network.
Huang ZJ, Li YJ, Yang J, Huang L, Zhao Q, Lu YF, Hu Y, Zhang WX, Liang JZ, Pan J, Pan YL, He QY, Wang Y
International journal of biological sciences 2024;20(6):2202-2218
International journal of biological sciences 2024;20(6):2202-2218
Lysozyme promotes renal fibrosis through the JAK/STAT3 signal pathway in diabetic nephropathy.
Ren Y, Yu M, Zheng D, He W, Jin J
Archives of medical science : AMS 2024;20(1):233-247
Archives of medical science : AMS 2024;20(1):233-247
Highly Ordered Nanotube-Like Microstructure on Titanium Dental Implant Surface Fabricated via Anodization Enhanced Cell Adhesion and Migration of Human Gingival Fibroblasts.
Deng Z, Yu L, Kuang Y, Zhou Z, Li X
International journal of nanomedicine 2024;19:2469-2485
International journal of nanomedicine 2024;19:2469-2485
Bone morphogenetic protein-6 suppresses TGF-β(2)-induced epithelial-mesenchymal transition in retinal pigment epithelium.
Liu X, Liu M, Ji M, Ma B, Hou YC, Yao XY, Cheng QC, Chen L
International journal of ophthalmology 2024;17(4):646-652
International journal of ophthalmology 2024;17(4):646-652
MicroRNA-204-5p Ameliorates Renal Injury via Regulating Keap1/Nrf2 Pathway in Diabetic Kidney Disease.
Dong J, Liu M, Bian Y, Zhang W, Yuan C, Wang D, Zhou Z, Li Y, Shi Y
Diabetes, metabolic syndrome and obesity : targets and therapy 2024;17:75-92
Diabetes, metabolic syndrome and obesity : targets and therapy 2024;17:75-92
Acute exposure to ultraviolet radiation targets proteins involved in collagen fibrillogenesis.
Platt CI, Stewart-McGuinness C, Eckersley A, Wilkins L, Sherratt MJ
Frontiers in physiology 2024;15:1352161
Frontiers in physiology 2024;15:1352161
Quantitative proteomics reveals the protective effects of Yinchenzhufu decoction against cholestatic liver fibrosis in mice by inhibiting the PDGFRβ/PI3K/AKT pathway.
Meng Q, Zhu H, Li Y, Peng X, Wang T, Huang H, Zhou H, Liu Y, Ru S, Wu J, Ma Y
Frontiers in pharmacology 2024;15:1341020
Frontiers in pharmacology 2024;15:1341020
Vitamin D binding protein (VDBP) hijacks twist1 to inhibit vasculogenic mimicry in hepatocellular carcinoma.
Qin LN, Zhang H, Li QQ, Wu T, Cheng SB, Wang KW, Shi Y, Ren HR, Xing XW, Yang C, Sun T
Theranostics 2024;14(1):436-450
Theranostics 2024;14(1):436-450
ELMO1 ameliorates intestinal epithelial cellular senescence via SIRT1/p65 signaling in inflammatory bowel disease-related fibrosis.
Chen J, Li G, He X, Chen X, Chen Z, Liu D, Guo S, Huang T, Lin Y, Lan P, Lian L, He X
Gastroenterology report 2024;12:goae045
Gastroenterology report 2024;12:goae045
PRM1201 effectively inhibits colorectal cancer metastasis via shaping gut microbiota and short- chain fatty acids.
Jia R, Shao S, Zhang P, Yuan Y, Rong W, An Z, Lv S, Feng Y, Liu N, Feng Q, Wang Y, Li Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155795
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155795
CircNSD1 promotes cardiac fibrosis through targeting the miR-429-3p/SULF1/Wnt/β-catenin signaling pathway.
Ji DN, Jin SD, Jiang Y, Xu FY, Fan SW, Zhao YL, Liu XQ, Sun H, Cheng WZ, Zhang XY, Guan XX, Zhang BW, Du ZM, Wang Y, Wang N, Zhang R, Zhang MY, Xu CQ
Acta pharmacologica Sinica 2024 Oct;45(10):2092-2106
Acta pharmacologica Sinica 2024 Oct;45(10):2092-2106
CCT6A alleviates pulmonary fibrosis by inhibiting HIF-1α-mediated lactate production.
Yan P, Yang K, Xu M, Zhu M, Duan Y, Li W, Liu L, Liang C, Li Z, Pan X, Wang L, Yu G
Journal of molecular cell biology 2024 Oct 21;16(5)
Journal of molecular cell biology 2024 Oct 21;16(5)
Gene Profiling of Circular RNAs in Keloid-prone Individuals and ceRNA Network Construction During Wound Healing.
Yang J, Zhu Z, Xu Y, Xu S, Zhang Y, Liu Z, Liu X, Shi J, Han B
Aesthetic plastic surgery 2024 Nov;48(21):4534-4545
Aesthetic plastic surgery 2024 Nov;48(21):4534-4545
Exposure to micron-grade silica particles triggers pulmonary fibrosis through cell-to-cell delivery of exosomal miR-107.
Xia J, Wang D, Guo W, Pei Y, Zhang L, Bao L, Li Y, Qu Y, Zhao Y, Hao C, Yao W
International journal of biological macromolecules 2024 May;266(Pt 1):131058
International journal of biological macromolecules 2024 May;266(Pt 1):131058
TGF-β1 inhibitor P144 protects against benign restenosis after esophageal stenting through TGF-β1/Smads signaling pathway inhibition.
Wu JZ, Zhou C, Liu S, Zhang JX, Yang W, Shi HB, Zhou WZ
Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology 2024 May;25(2):214-222
Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology 2024 May;25(2):214-222
Kefir peptides mitigate bleomycin-induced pulmonary fibrosis in mice through modulating oxidative stress, inflammation and gut microbiota.
Lan YW, Chen YC, Yen CC, Chen HL, Tung MC, Fan HC, Chen CM
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116431
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116431
Pirfenidone alleviates fibrosis by acting on tumour-stroma interplay in pancreatic cancer.
Lei Y, Xu J, Xiao M, Wu D, Xu H, Yang J, Mao X, Pan H, Yu X, Shi S
British journal of cancer 2024 May;130(9):1505-1516
British journal of cancer 2024 May;130(9):1505-1516
Effects of Nanoparticle-Mediated Dihydromyricetin to Diabetic Wounds: An In Vivo Study.
Wang ZN, Ma JC, Xi MF, Yin D, Jiang LF, Qi J
Journal of burn care & research : official publication of the American Burn Association 2024 May 6;45(3):644-654
Journal of burn care & research : official publication of the American Burn Association 2024 May 6;45(3):644-654
Generation and application of immortalized sheep fetal fibroblast cell line.
Du G, Zhang C, Cao X, Li L, Zhang Y, Shang Y, Wu J
BMC veterinary research 2024 May 14;20(1):198
BMC veterinary research 2024 May 14;20(1):198
The Rejuvenation and Functional Restoration of Aged Adipose Stem Cells by DUXAP10 Knockdown via the Regulation of the miR-214-3p/RASSF5 Axis.
Ren S, Li C, Xiong H, Wu Q, Wu X, Xiong Z, Dong L, Shu B, Wei W, Ma C, Li X, Chen J
Stem cells translational medicine 2024 May 14;13(5):462-476
Stem cells translational medicine 2024 May 14;13(5):462-476
Remimazolam attenuates inflammation and kidney fibrosis following folic acid injury.
Song J, Yu W, Chen S, Huang J, Zhou C, Liang H
European journal of pharmacology 2024 Mar 5;966:176342
European journal of pharmacology 2024 Mar 5;966:176342
Astaxanthin attenuates cigarette smoke-induced small airway remodeling via the AKT1 signaling pathway.
Ding H, Yan L, Wang Y, Lu Y, Deng M, Wang Y, Wang Q, Zhou X
Respiratory research 2024 Mar 30;25(1):148
Respiratory research 2024 Mar 30;25(1):148
Wnt5a/β-catenin-mediated epithelial-mesenchymal transition: a key driver of subretinal fibrosis in neovascular age-related macular degeneration.
Liu D, Du J, Xie H, Tian H, Lu L, Zhang C, Xu GT, Zhang J
Journal of neuroinflammation 2024 Mar 26;21(1):75
Journal of neuroinflammation 2024 Mar 26;21(1):75
Nuciferine reduces vascular leakage and improves cardiac function in acute myocardial infarction by regulating the PI3K/AKT pathway.
Xie W, Chen S, Wang W, Qin X, Kong C, Wang D
Scientific reports 2024 Mar 26;14(1):7086
Scientific reports 2024 Mar 26;14(1):7086
PDE12 disrupts mitochondrial oxidative phosphorylation and mediates mitochondrial dysfunction to induce oral mucosal epithelial barrier damage in oral submucous fibrosis.
Wei Q, Chen L, Luo W, Chen C, Shi Y, Xie J, Xie X, Luo HB
European journal of pharmacology 2024 Mar 15;967:176353
European journal of pharmacology 2024 Mar 15;967:176353
Preventive effects of Ramelteon on bleomycin-induced pulmonary fibrosis in mice.
Zhang L, Cheng T, Chen W, Zhong C, Li M, Xie Y, Deng Q, Wang H, Yang Z, Ju J, Liang H
Naunyn-Schmiedeberg's archives of pharmacology 2024 Jun;397(6):4153-4163
Naunyn-Schmiedeberg's archives of pharmacology 2024 Jun;397(6):4153-4163
Kokusaginine attenuates renal fibrosis by inhibiting the PI3K/AKT signaling pathway.
Wang Y, Han Y, Shang K, Xiao J, Tao L, Peng Z, Liu S, Jiang Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jun;175:116695
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jun;175:116695
Synergistic effects of photodynamic therapy and chemotherapy: Activating the intrinsic/extrinsic apoptotic pathway of anoikis for triple-negative breast cancer treatment.
Zhang T, Wang X, Wang D, Lei M, Hu Y, Chen Z, Li Y, Luo Y, Zhang L, Zhu Y
Biomaterials advances 2024 Jun;160:213859
Biomaterials advances 2024 Jun;160:213859
Platelet membrane biomimetic nanoparticle-targeted delivery of TGF-β1 siRNA attenuates renal inflammation and fibrosis.
Fei S, Ma Y, Zhou B, Chen X, Zhang Y, Yue K, Li Q, Gui Y, Xiang T, Liu J, Yang B, Wang L, Huang X
International journal of pharmaceutics 2024 Jun 25;659:124261
International journal of pharmaceutics 2024 Jun 25;659:124261
Parkin deficiency promotes liver cancer metastasis by TMEFF1 transcription activation via TGF-β/Smad2/3 pathway.
Su Q, Wang JJ, Ren JY, Wu Q, Chen K, Tu KH, Zhang Y, Leong SW, Sarwar A, Han X, Zhang M, Dai WF, Zhang YM
Acta pharmacologica Sinica 2024 Jul;45(7):1520-1529
Acta pharmacologica Sinica 2024 Jul;45(7):1520-1529
Long Non-coding RNA ZFAS1 Regulates Fibrosis and Scortosis in the Cell Model of Diabetic Nephropathy Through miR-525-5p/SGK1 Axis.
Zhuang L, Jin G, Wang Q, Ge X, Pei X
Applied biochemistry and biotechnology 2024 Jul;196(7):3731-3746
Applied biochemistry and biotechnology 2024 Jul;196(7):3731-3746
The histone deacetylase inhibitor MS-275 enhances the matrix mineralization of dental pulp stem cells by inducing fibronectin expression.
Suzuki S, Sasaki K, Fahreza RR, Nemoto E, Yamada S
Journal of dental sciences 2024 Jul;19(3):1680-1690
Journal of dental sciences 2024 Jul;19(3):1680-1690
Hydrogen Therapy Reverses Cancer-Associated Fibroblasts Phenotypes and Remodels Stromal Microenvironment to Stimulate Systematic Anti-Tumor Immunity.
Meng X, Liu Z, Deng L, Yang Y, Zhu Y, Sun X, Hao Y, He Y, Fu J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jul;11(28):e2401269
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jul;11(28):e2401269
Icariside II modulates pulmonary fibrosis via PI3K/Akt/β-catenin pathway inhibition of M2 macrophage program.
Deng L, Ouyang B, Tang W, Wang N, Yang F, Shi H, Zhang Z, Yu H, Chen M, Wei Y, Dong J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155687
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155687
Cell fusion upregulates PD-L1 expression for evasion from immunosurveillance.
Tajima Y, Shibasaki F, Masai H
Cancer gene therapy 2024 Jan;31(1):158-173
Cancer gene therapy 2024 Jan;31(1):158-173
Chitosan-based oral nanoparticles as an efficient platform for kidney-targeted drug delivery in the treatment of renal fibrosis.
Zhang Q, Li Y, Wang S, Gu D, Zhang C, Xu S, Fang X, Li C, Wu H, Xiong W
International journal of biological macromolecules 2024 Jan;256(Pt 1):128315
International journal of biological macromolecules 2024 Jan;256(Pt 1):128315
Lactate accumulation induced by Akt2-PDK1 signaling promotes pulmonary fibrosis.
Sun Z, Ji Z, He W, Duan R, Qu J, Yu G
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan 31;38(2):e23426
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan 31;38(2):e23426
In silico prediction and experimental validation to reveal the protective mechanism of Puerarin against excessive extracellular matrix accumulation through inhibiting ferroptosis in diabetic nephropathy.
Hou B, Ma P, Yang X, Zhao X, Zhang L, Zhao Y, He P, Zhang L, Du G, Qiang G
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117281
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117281
A cardiotoxicity-eliminated ACE2 variant as a pan-inhibitor against coronavirus cell invasion.
Feng H, Yang L, Yang H, Cheng D, Li M, Song E, Xu T
Molecular therapy : the journal of the American Society of Gene Therapy 2024 Jan 3;32(1):218-226
Molecular therapy : the journal of the American Society of Gene Therapy 2024 Jan 3;32(1):218-226
Inhibition of heme oxygenase 1 alleviates thoracic aortic aneurysm via restoration of extracellular matrix.
Song W, Shen K, Fu G, Qin L, Bagaber G, Chen J, Wei L
Biochemical and biophysical research communications 2024 Jan 29;694:149405
Biochemical and biophysical research communications 2024 Jan 29;694:149405
Rehmannia glutinosa Libosch and Cornus officinalis Sieb herb couple ameliorates renal interstitial fibrosis in CKD rats by inhibiting the TGF-β1/MAPK signaling pathway.
Zhu JH, Wang L, Ma ZX, Duan JA, Tao JH
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117039
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117039
hPMSCs Regulate the Level of TNF-α and IL-10 in Th1 Cells and Improve Hepatic Injury in a GVHD Mouse Model via CD73/ADO/Fyn/Nrf2 Axis.
Zhang H, Han K, Li H, Zhang J, Zhao Y, Wu Y, Wang B, Ma J, Luan X
Inflammation 2024 Feb;47(1):244-263
Inflammation 2024 Feb;47(1):244-263
Microplastics cause hepatotoxicity in diabetic mice by disrupting glucolipid metabolism via PP2A/AMPK/HNF4A and promoting fibrosis via the Wnt/β-catenin pathway.
Li X, Feng L, Kuang Q, Wang X, Yang J, Niu X, Gao L, Huang L, Luo P, Li L
Environmental toxicology 2024 Feb;39(2):1018-1030
Environmental toxicology 2024 Feb;39(2):1018-1030
Alleviative Effect of Lactoferrin Interventions Against the Hepatotoxicity Induced by Titanium Dioxide Nanoparticles.
Zhang W, Sun J, Liu F, Li S, Wang X, Su L, Liu G
Biological trace element research 2024 Feb;202(2):624-642
Biological trace element research 2024 Feb;202(2):624-642
Targeting ROCK1 in diabetic kidney disease: Unraveling mesangial fibrosis mechanisms and introducing myricetin as a novel antagonist.
Yuan N, Diao J, Dong J, Yan Y, Chen Y, Yan S, Liu C, He Z, He J, Zhang C, Wang H, Wang M, He F, Xiao W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Feb;171:116208
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Feb;171:116208
Discovery of PRDM16-Mediated TRPA1 Induction as the Mechanism for Low Tubulo-Interstitial Fibrosis in Diabetic Kidney Disease.
Xu F, Jiang H, Li X, Pan J, Li H, Wang L, Zhang P, Chen J, Qiu S, Xie Y, Li Y, Zhang D, Dong Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Feb;11(7):e2306704
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Feb;11(7):e2306704
Endothelium-specific deletion of p62 causes organ fibrosis and cardiac dysfunction.
Feng J, Li Y, Zhang Y, Sun S, Sun J, Xu Q, Ji X, Liu Y, Wan Q
Journal of translational medicine 2024 Feb 16;22(1):161
Journal of translational medicine 2024 Feb 16;22(1):161
Pachymic acid ameliorates bleomycin-induced pulmonary fibrosis through inhibiting endoplasmic reticulum stress in rats.
Li L, Jin RJ, Ji L
Environmental toxicology 2024 Dec;39(12):5382-5390
Environmental toxicology 2024 Dec;39(12):5382-5390
Lipoamide Attenuates Hypertensive Myocardial Hypertrophy Through PI3K/Akt-Mediated Nrf2 Signaling Pathway.
Cao H, Zhao L, Yuan Y, Liao C, Zeng W, Li A, Huang Q, Zhao Y, Fan Y, Jiang L, Song D, Li S, Zhang B
Journal of cardiovascular translational research 2024 Aug;17(4):910-922
Journal of cardiovascular translational research 2024 Aug;17(4):910-922
CD146-dependent macrophage infiltration promotes epidural fibrosis via the Erdr1/ERK/CCR2 pathway.
Sun J, Shi M, Song Z, Hua F, Yan X, Zhang M, Duan H, Liu J
International immunopharmacology 2024 Aug 20;137:112528
International immunopharmacology 2024 Aug 20;137:112528
VDR regulates mitochondrial function as a protective mechanism against renal tubular cell injury in diabetic rats.
Chen H, Zhang H, Li AM, Liu YT, Liu Y, Zhang W, Yang C, Song N, Zhan M, Yang S
Redox biology 2024 Apr;70:103062
Redox biology 2024 Apr;70:103062
BMSC-derived Exosomes Ameliorate Peritoneal Dialysis-associated Peritoneal Fibrosis via the Mir-27a-3p/TP53 Pathway.
Zhao JL, Zhao L, Zhan QN, Liu M, Zhang T, Chu WW
Current medical science 2024 Apr;44(2):333-345
Current medical science 2024 Apr;44(2):333-345
Bone morphogenetic protein 6 (BMP6) antagonises experimental proliferative vitreoretinopathy established by TGF-β2 stimulation in retinal pigment epithelial cells through modulation of the p38 and JNK MAPK pathways.
Liu X, Liu M, Chen L
Cell and tissue research 2024 Apr;396(1):103-117
Cell and tissue research 2024 Apr;396(1):103-117
The regulatory role of the apelin/APJ axis in scarring: Identification of upstream and downstream mechanisms.
Shi N, Wang Y, Xia Z, Zhang J, Jia S, Jiao Y, Wang C, Wang X, Zhao J, Zhang J, Jiang D
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167125
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167125
Therapeutic effects of in vivo administration of an inhibitor of tryptophan 2,3-dioxygenase (680c91) for the treatment of fibroids: a preclinical study.
Chuang TD, Ton N, Rysling S, Quintanilla D, Boos D, Khorram O
Fertility and sterility 2024 Apr;121(4):669-678
Fertility and sterility 2024 Apr;121(4):669-678
NBR1-p62-Nrf2 mediates the anti-pulmonary fibrosis effects of protodioscin.
Zeng Q, Wen BB, Liu X, Luo YY, Hu ZG, Huang L, Zhang XH, Huang XT, Zhou TT, Sang XX, Luo YY, Xiong DY, Luo ZQ, Liu W, Tang SY
Chinese medicine 2024 Apr 8;19(1):60
Chinese medicine 2024 Apr 8;19(1):60
DEC1 is involved in circadian rhythm disruption-exacerbated pulmonary fibrosis.
Chen SJ, Yu F, Feng X, Li Q, Jiang YH, Zhao LQ, Cheng PP, Wang M, Song LJ, Liang LM, He XL, Xiong L, Xiang F, Wang X, Ye H, Ma WL
Cell communication and signaling : CCS 2024 Apr 26;22(1):245
Cell communication and signaling : CCS 2024 Apr 26;22(1):245
Jin-Gui-Shen-Qi Wan alleviates fibrosis in mouse diabetic nephropathy via MHC class II.
Liang D, Liu L, Qi Y, Nan F, Huang J, Tang S, Tang J, Chen N
Journal of ethnopharmacology 2024 Apr 24;324:117745
Journal of ethnopharmacology 2024 Apr 24;324:117745
Favipiravir ameliorates bleomycin-induced pulmonary fibrosis by reprogramming M1/M2 macrophage polarization.
Zhang R, Jiang Q, Gao S, Zhang H, Xia Q, Liu B, Zhu J, Jiang H, Zhao R, Dong H, Li X, Zhang Y, Yang C, Gu X, Sun L, Zhou H
International immunopharmacology 2024 Apr 20;131:111774
International immunopharmacology 2024 Apr 20;131:111774
Bioinformatics-based dynamics of cuproptosis -related indicators in experimental silicosis.
Xia J, Wu C, Jin X, Ding M, Zhang C, Hou G, Hao C, Yao W
Ecotoxicology and environmental safety 2024 Apr 15;275:116286
Ecotoxicology and environmental safety 2024 Apr 15;275:116286
Propofol improves ischemia reperfusion-induced liver fibrosis by regulating lncRNA HOXA11-AS.
Luo J, Liu J, Mou Y, Luo F, Liao Q, Liao Y
The Journal of toxicological sciences 2023;48(6):345-354
The Journal of toxicological sciences 2023;48(6):345-354
Up-regulated SPP1 increases the risk from IPF to lung cancer via activating the pro-tumor macrophages.
Chen T, Guo J, Ai L, Wang Y, Wang Y, Chen B, Liu M, Zhuang S, Liu K, Zhao Z, Liang H, Gu Y
Computational and structural biotechnology journal 2023;21:5751-5764
Computational and structural biotechnology journal 2023;21:5751-5764
hucMSC-Ex Alleviates IBD-Associated Intestinal Fibrosis by Inhibiting ERK Phosphorylation in Intestinal Fibroblasts.
Wang Y, Zhang Y, Lu B, Xi J, Ocansey DKW, Mao F, Hao D, Yan Y
Stem cells international 2023;2023:2828981
Stem cells international 2023;2023:2828981
FAT10 Silencing Prevents Liver Fibrosis through Regulating SIRT1 Expression in Hepatic Stellate Cells.
Zheng W, Guan F, Xu G, Yu Y, Xiao J, Huang X
International journal of medical sciences 2023;20(4):557-565
International journal of medical sciences 2023;20(4):557-565
Combining Porous Se@SiO(2) Nanocomposites and dECM Enhances the Myogenic Differentiation of Adipose-Derived Stem Cells.
Zhang YC, Yang YX, Liu Y, Liu XJ, Dai JH, Gao RS, Hu YY, Fei WY
International journal of nanomedicine 2023;18:7661-7676
International journal of nanomedicine 2023;18:7661-7676
Effects of autophagy inhibitor 3-methyladenine on a diabetic mice model.
Ren HW, Yu W, Wang YN, Zhang XY, Song SQ, Gong SY, Meng LY, Gan C, Liu BJ, Gong Q
International journal of ophthalmology 2023;16(9):1456-1464
International journal of ophthalmology 2023;16(9):1456-1464
Irisin Ameliorates Renal Tubulointerstitial Fibrosis by Regulating the Smad4/β-Catenin Pathway in Diabetic Mice.
Yang Z, Wei J, Wang Y, Du Y, Song S, Li J, Su Z, Shi Y, Wu H
Diabetes, metabolic syndrome and obesity : targets and therapy 2023;16:1577-1593
Diabetes, metabolic syndrome and obesity : targets and therapy 2023;16:1577-1593
CXCL5 knockdown attenuated gemcitabine resistance of pancreatic cancer through regulation of cancer cells and tumour stroma.
Lee NH, Ma Y, Ang CS, Dumesny C, Huynh N, Yang Y, Wang K, Nikfarjam M, He H
American journal of translational research 2023;15(4):2676-2689
American journal of translational research 2023;15(4):2676-2689
Identification and validation of chemokine system-related genes in idiopathic pulmonary fibrosis.
Zhao T, Wu X, Zhao X, Yao K, Li X, Ni J
Frontiers in immunology 2023;14:1159856
Frontiers in immunology 2023;14:1159856
Apolipoprotein A-I attenuates peritoneal fibrosis associated with peritoneal dialysis by inhibiting oxidative stress and inflammation.
Lu J, Gao J, Sun J, Wang H, Sun H, Huang Q, Zhang Y, Zhong S
Frontiers in pharmacology 2023;14:1106339
Frontiers in pharmacology 2023;14:1106339
Dapagliflozin alleviates renal fibrosis in a mouse model of adenine-induced renal injury by inhibiting TGF-β1/MAPK mediated mitochondrial damage.
Zeng J, Huang H, Zhang Y, Lv X, Cheng J, Zou SJ, Han Y, Wang S, Gong L, Peng Z
Frontiers in pharmacology 2023;14:1095487
Frontiers in pharmacology 2023;14:1095487
Gastrodin attenuates renal injury and collagen deposition via suppression of the TGF-β1/Smad2/3 signaling pathway based on network pharmacology analysis.
Wen Y, Zhang X, Wei L, Wu M, Cheng Y, Zheng H, Shen A, Fu C, Ali F, Long L, Lu Y, Li J, Peng J
Frontiers in pharmacology 2023;14:1082281
Frontiers in pharmacology 2023;14:1082281
EZH2 and matrix co-regulate phenotype and KCNB2 expression in bladder smooth muscle cells.
Yadav P, Ahmed T, Park S, Sidler M, Schröder A, Aitken KJ, Bägli D
American journal of clinical and experimental urology 2023;11(4):293-303
American journal of clinical and experimental urology 2023;11(4):293-303
Differentially expressed genes in orbital adipose/connective tissue of thyroid-associated orbitopathy.
Wang Y, Liu Y, Cai J, Zong T, Zhang Z, Xie T, Mu T, Wu M, Yang Q, Wang Y, Wang X, Yao Y
PeerJ 2023;11:e16569
PeerJ 2023;11:e16569
Ferroptosis-dependent breast cancer cell-derived exosomes inhibit migration and invasion of breast cancer cells by suppressing M2 macrophage polarization.
Yi C, Wu S, Duan Q, Liu L, Li L, Luo Y, Wang A
PeerJ 2023;11:e15060
PeerJ 2023;11:e15060
Sclareol attenuates liver fibrosis through SENP1-mediated VEGFR2 SUMOylation and inhibition of downstream STAT3 signaling.
Ge MX, Niu WX, Bao YY, Lu ZN, He HW
Phytotherapy research : PTR 2023 Sep;37(9):3898-3912
Phytotherapy research : PTR 2023 Sep;37(9):3898-3912
Comparing Effects of Short- and Long-Term Exposure of Cigarette Smoke Extract on Human Vocal Fold Fibroblasts.
Steffan B, Grossmann T, Grill M, Kirsch A, Groselj-Strele A, Gugatschka M
Journal of voice : official journal of the Voice Foundation 2023 Sep 9;
Journal of voice : official journal of the Voice Foundation 2023 Sep 9;
Embryo-uterine interaction coordinates mouse embryogenesis during implantation.
Bondarenko V, Nikolaev M, Kromm D, Belousov R, Wolny A, Blotenburg M, Zeller P, Rezakhani S, Hugger J, Uhlmann V, Hufnagel L, Kreshuk A, Ellenberg J, van Oudenaarden A, Erzberger A, Lutolf MP, Hiiragi T
The EMBO journal 2023 Sep 4;42(17):e113280
The EMBO journal 2023 Sep 4;42(17):e113280
Omentin-1 induces mechanically activated fibroblasts lipogenic differentiation through pkm2/yap/pparγ pathway to promote lung fibrosis resolution.
Zhang Y, Fu J, Li C, Chang Y, Li X, Cheng H, Qiu Y, Shao M, Han Y, Feng D, Yue S, Sun Z, Luo Z, Zhou Y
Cellular and molecular life sciences : CMLS 2023 Sep 28;80(10):308
Cellular and molecular life sciences : CMLS 2023 Sep 28;80(10):308
Long non-coding RNA MIDEAS-AS1 inhibits growth and metastasis of triple-negative breast cancer via transcriptionally activating NCALD.
Luo D, Liang Y, Wang Y, Ye F, Jin Y, Li Y, Han D, Wang Z, Chen B, Zhao W, Wang L, Chen X, Jiang L, Yang Q
Breast cancer research : BCR 2023 Sep 28;25(1):109
Breast cancer research : BCR 2023 Sep 28;25(1):109
Multi-targeting liposomal codelivery of cisplatin and rapamycin inhibits pancreatic cancer growth and metastasis through stromal modulation.
Zhu W, Yu H, Jia M, Lin C, Yuan Z, Tan X, Yan P
International journal of pharmaceutics 2023 Sep 25;644:123316
International journal of pharmaceutics 2023 Sep 25;644:123316
Fraxin represses NF-κB pathway via inhibiting the activation of epidermal growth factor receptor to ameliorate diabetic renal tubulointerstitial fibrosis.
Zeng J, Liang L, Chen R, Li C, Pan L, Wen M, Lv D, Liu M, Xu Z, Huang H
European journal of pharmacology 2023 Sep 15;955:175915
European journal of pharmacology 2023 Sep 15;955:175915
Targeting STING-mediated pro-inflammatory and pro-fibrotic effects of alveolar macrophages and fibroblasts blunts silicosis caused by silica particles.
Ou L, Zhang P, Huang Z, Cheng Y, Miao Q, Niu R, Hu Y, Chen Y
Journal of hazardous materials 2023 Sep 15;458:131907
Journal of hazardous materials 2023 Sep 15;458:131907
Qingda granule ameliorates vascular remodeling and phenotypic transformation of adventitial fibroblasts via suppressing the TGF-β1/Smad2/3 pathway.
Wu M, Zhang S, Zhang W, Zhou Y, Guo Z, Fang Y, Yang Y, Shen Z, Lian D, Shen A, Peng J
Journal of ethnopharmacology 2023 Sep 15;313:116535
Journal of ethnopharmacology 2023 Sep 15;313:116535
MYCT1 attenuates renal fibrosis and tubular injury in diabetic kidney disease.
Li X, Fan QL, Ma TK, Liu C, Shi H, Sun YY, Wang Y, Ding DX, Tang A, Qin Y, Yang Q, Ding H, Li HY, Fu WN
iScience 2023 Sep 15;26(9):107609
iScience 2023 Sep 15;26(9):107609
Nephroprotective Effects of Cardamonin on Renal Ischemia Reperfusion Injury/UUO-Induced Renal Fibrosis.
Zhang B, Chen ZY, Jiang Z, Huang S, Liu XH, Wang L
Journal of agricultural and food chemistry 2023 Sep 13;71(36):13284-13303
Journal of agricultural and food chemistry 2023 Sep 13;71(36):13284-13303
N-methylpiperazine-diepoxyovatodiolide ameliorates peritoneal fibrosis via suppressing TGF-β/Smad and JAK/STAT signaling pathway.
Mo M, Zeng Y, Zeng Y, Li S, He X, Chen X, Luo Q, Liu M, Luo C, Dou X, Peng F, Long H
Chemico-biological interactions 2023 Sep 1;382:110589
Chemico-biological interactions 2023 Sep 1;382:110589
Ceruloplasmin regulating fibrosis in orbital fibroblasts provides a novel therapeutic target for Graves' orbitopathy.
Cao J, Qi X, Wang N, Chen Y, Xie B, Ma C, Chen Z, Xiong W
Journal of endocrinological investigation 2023 Oct;46(10):2005-2016
Journal of endocrinological investigation 2023 Oct;46(10):2005-2016
Pregnane X receptor activation alleviates renal fibrosis in mice via interacting with p53 and inhibiting the Wnt7a/β-catenin signaling.
Ming WH, Luan ZL, Yao Y, Liu HC, Hu SY, Du CX, Zhang C, Zhao YH, Huang YZ, Sun XW, Qiao RF, Xu H, Guan YF, Zhang XY
Acta pharmacologica Sinica 2023 Oct;44(10):2075-2090
Acta pharmacologica Sinica 2023 Oct;44(10):2075-2090
Nucleosome assembly protein 1 like 1 (NAP1L1) promotes cardiac fibrosis by inhibiting YAP1 ubiquitination and degradation.
Li T, Niu Z, Yu T, Li J, Lu X, Huang M, Wang Q, Yu X, Feng J, Xu B, Bing D, Li X, Lu L, Liang H, Yang R, Wang B, Shan H
MedComm 2023 Oct;4(5):e348
MedComm 2023 Oct;4(5):e348
Can targeted nanoparticles distinguish cancer metastasis from inflammation?
Choi AS, Moon TJ, Abuhashim W, Bhalotia A, Qian H, Paulsen KE, Lorkowski M, Ndamira C, Gopalakrishnan R, Krishnamurthy A, Schiemann WP, Karathanasis E
Journal of controlled release : official journal of the Controlled Release Society 2023 Oct;362:812-819
Journal of controlled release : official journal of the Controlled Release Society 2023 Oct;362:812-819
KCTD4 interacts with CLIC1 to disrupt calcium homeostasis and promote metastasis in esophageal cancer.
Zheng C, Yu X, Xu T, Liu Z, Jiang Z, Xu J, Yang J, Zhang G, He Y, Yang H, Shi X, Li Z, Liu J, Xu WW
Acta pharmaceutica Sinica. B 2023 Oct;13(10):4217-4233
Acta pharmaceutica Sinica. B 2023 Oct;13(10):4217-4233
Fu-Zheng-Tong-Luo formula promotes autophagy and alleviates idiopathic pulmonary fibrosis by controlling the Janus kinase 2/signal transducer and activator of transcription 3 pathway.
Zhang X, Su J, Lin J, Liu L, Wu J, Yuan W, Zhang Y, Chen Q, Su ZJ, Xu G, Sun M, Zhang Y, Chen X, Zhang W
Journal of ethnopharmacology 2023 Oct 5;314:116633
Journal of ethnopharmacology 2023 Oct 5;314:116633
Neuroepithelial cell-transforming 1 promotes cardiac fibrosis via the Wnt/β-catenin signaling pathway.
Li T, Xiong X, Wang Y, Li Y, Liu Y, Zhang M, Li C, Yu T, Cao W, Chen S, Zhang H, Wang X, Lv L, Zhou Y, Liang H, Li X, Shan H
iScience 2023 Oct 20;26(10):107888
iScience 2023 Oct 20;26(10):107888
Proximal Tubular Lats2 Ablation Exacerbates Ischemia/Reperfusion Injury (IRI)-Induced Renal Maladaptive Repair through the Upregulation of P53.
Zhang C, Zheng Z, Xu K, Cheng G, Wu H, Liu J
International journal of molecular sciences 2023 Oct 17;24(20)
International journal of molecular sciences 2023 Oct 17;24(20)
Liraglutide intervention improves high-glucose-induced reactive gliosis of Müller cells and ECM dysregulation.
Shan Y, Gao X, Zhao K, Xu C, Li H, Hu Y, Lin W, Ma X, Xu Q, Kuang H, Hao M
Molecular and cellular endocrinology 2023 Oct 1;576:112013
Molecular and cellular endocrinology 2023 Oct 1;576:112013
Mannan-binding lectin ameliorates renal fibrosis by suppressing macrophage-to-myofibroblast transition.
Xu L, Jiang H, Xie J, Xu Q, Zhou J, Lu X, Wang M, Dong L, Zuo D
Heliyon 2023 Nov;9(11):e21882
Heliyon 2023 Nov;9(11):e21882
Local administration of liposomal-based Plekhf1 gene therapy attenuates pulmonary fibrosis by modulating macrophage polarization.
Yan L, Hou C, Liu J, Wang Y, Zeng C, Yu J, Zhou T, Zhou Q, Duan S, Xiong W
Science China. Life sciences 2023 Nov;66(11):2571-2586
Science China. Life sciences 2023 Nov;66(11):2571-2586
Hyperbranched polyamidoamine-RGD peptide/si-circICA1 in the treatment of invasive thyroid cancer through targeting of the miR-486-3p/SERPINA1 axis.
Dong S, Xia Q, Pan J, Du XL, Wu YJ, Xie XJ
Nanomedicine (London, England) 2023 Nov;18(27):2039-2059
Nanomedicine (London, England) 2023 Nov;18(27):2039-2059
SETD2 deficiency promotes renal fibrosis through the TGF-β/Smad signalling pathway in the absence of VHL.
Liu C, Ni L, Li X, Rao H, Feng W, Zhu Y, Zhang W, Ma C, Xu Y, Gui L, Wang Z, Aji R, Xu J, Gao WQ, Li L
Clinical and translational medicine 2023 Nov;13(11):e1468
Clinical and translational medicine 2023 Nov;13(11):e1468
Melatonin exerts a protective effect in ameliorating nephrolithiasis via targeting AMPK/PINK1-Parkin mediated mitophagy and inhibiting ferroptosis in vivo and in vitro.
Zhou J, Meng L, He Z, Song Q, Liu J, Su X, Wang C, Ke H, Dong C, Liao W, Yang S
International immunopharmacology 2023 Nov;124(Pt A):110801
International immunopharmacology 2023 Nov;124(Pt A):110801
Guanxin V alleviates ventricular remodeling by promoting transforming growth factor-beta 1-mediated proteasomal degradation of Vimentin.
Gu N, Liang B
Poultry science 2023 Nov;102(11):103026
Poultry science 2023 Nov;102(11):103026
Defining the identity and the niches of epithelial stem cells with highly pleiotropic multilineage potency in the human thymus.
Ragazzini R, Boeing S, Zanieri L, Green M, D'Agostino G, Bartolovic K, Agua-Doce A, Greco M, Watson SA, Batsivari A, Ariza-McNaughton L, Gjinovci A, Scoville D, Nam A, Hayday AC, Bonnet D, Bonfanti P
Developmental cell 2023 Nov 20;58(22):2428-2446.e9
Developmental cell 2023 Nov 20;58(22):2428-2446.e9
Prolonged exposure to the herbicide atrazine promotes kidney fibrosis by activating Wnt/β-catenin signaling in rats.
Wang T, Huang X, Liu J, Liu W, Yang Z, He K, Chen J, Zhao L
Environmental toxicology 2023 May;38(5):1143-1152
Environmental toxicology 2023 May;38(5):1143-1152
CircRNA_0017076 acts as a sponge for miR-185-5p in the control of epithelial-to-mesenchymal transition of tubular epithelial cells during renal interstitial fibrosis.
Zhang F, Zou H, Li X, Liu J, Xie Y, Chen M, Yu J, Wu X, Guo B
Human cell 2023 May;36(3):1024-1040
Human cell 2023 May;36(3):1024-1040
Lysine 2-hydroxyisobutyrylation of NAT10 promotes cancer metastasis in an ac4C-dependent manner.
Liao L, He Y, Li SJ, Yu XM, Liu ZC, Liang YY, Yang H, Yang J, Zhang GG, Deng CM, Wei X, Zhu YD, Xu TY, Zheng CC, Cheng C, Li A, Li ZG, Liu JB, Li B
Cell research 2023 May;33(5):355-371
Cell research 2023 May;33(5):355-371
Nicotine exposure exacerbates silica-induced pulmonary fibrosis via STAT3-BDNF-TrkB-mediated epithelial-mesenchymal transition in alveolar type II cells.
Chen H, Tao X, Cao H, Li B, Sun Q, Wang W, Zou Y, Mu M, Tao H, Zhao Y, Ge D
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 May;175:113694
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 May;175:113694
HDAC9-mediated epithelial cell cycle arrest in G2/M contributes to kidney fibrosis in male mice.
Zhang Y, Yang Y, Yang F, Liu X, Zhan P, Wu J, Wang X, Wang Z, Tang W, Sun Y, Zhang Y, Xu Q, Shang J, Zhen J, Liu M, Yi F
Nature communications 2023 May 25;14(1):3007
Nature communications 2023 May 25;14(1):3007
Splicing factor YBX1 regulates bone marrow stromal cell fate during aging.
Xiao Y, Cai GP, Feng X, Li YJ, Guo WH, Guo Q, Huang Y, Su T, Li CJ, Luo XH, Zheng YJ, Yang M
The EMBO journal 2023 May 2;42(9):e111762
The EMBO journal 2023 May 2;42(9):e111762
Crosstalk between the JAK2 and TGF-β1 signaling pathways in scleroderma-related interstitial lung disease targeted by baricitinib.
Wang D, Wei Y, Xu L, Zhang J
Advances in rheumatology (London, England) 2023 May 16;63(1):22
Advances in rheumatology (London, England) 2023 May 16;63(1):22
Ginsenoside Rb1 promotes the activation of PPARα pathway via inhibiting FADD to ameliorate heart failure.
Li C, Zhang X, Li J, Liang L, Zeng J, Wen M, Pan L, Lv D, Liu M, Cheng Y, Huang H
European journal of pharmacology 2023 May 15;947:175676
European journal of pharmacology 2023 May 15;947:175676
USP22 aggravated diabetic renal tubulointerstitial fibrosis progression through deubiquitinating and stabilizing Snail1.
Zhao X, He X, Wei W, Huang K
European journal of pharmacology 2023 May 15;947:175671
European journal of pharmacology 2023 May 15;947:175671
Aristolocholic acid I promotes renal tubular epithelial fibrosis by upregulating matrix metalloproteinase-9 expression via activating the C3a/C3aR axis of macrophages.
Zhang Q, Ye J, Zhang Z, Hu Y, Wang X, Jiang W, Guo X, Chen L, Cheng S, Li J, Zhang L
Toxicology letters 2023 May 15;381:27-35
Toxicology letters 2023 May 15;381:27-35
PRMT2 promotes RCC tumorigenesis and metastasis via enhancing WNT5A transcriptional expression.
Li Z, Chen C, Yong H, Jiang L, Wang P, Meng S, Chu S, Li Z, Guo Q, Zheng J, Bai J, Li H
Cell death & disease 2023 May 12;14(5):322
Cell death & disease 2023 May 12;14(5):322
Yishen Tongluo formula alleviates diabetic kidney disease through regulating Sirt6/TGF-β1/Smad2/3 pathway and promoting degradation of TGF-β1.
Zhang X, Zhao L, Xiang S, Sun Y, Wang P, Chen JJ, Teo BS, Xie Z, Zhang Z, Xu J
Journal of ethnopharmacology 2023 May 10;307:116243
Journal of ethnopharmacology 2023 May 10;307:116243
Interferon regulatory factor 4 deletion protects against kidney inflammation and fibrosis in deoxycorticosterone acetate/salt hypertension.
Gao Y, Liu B, Guo X, Nie J, Zou H, Wen S, Yu W, Liang H
Journal of hypertension 2023 May 1;41(5):794-810
Journal of hypertension 2023 May 1;41(5):794-810
N4-acetylcytidine modification of lncRNA CTC-490G23.2 promotes cancer metastasis through interacting with PTBP1 to increase CD44 alternative splicing.
Yu XM, Li SJ, Yao ZT, Xu JJ, Zheng CC, Liu ZC, Ding PB, Jiang ZL, Wei X, Zhao LP, Shi XY, Li ZG, Xu WW, Li B
Oncogene 2023 Mar;42(14):1101-1116
Oncogene 2023 Mar;42(14):1101-1116
Rapid formation of 3D: Decellularized extracellular matrix spheroids for enhancing bone formation.
Zhang Y, Feng Y, Shao Q, Jiang Z, Yang G
Journal of biomedical materials research. Part A 2023 Mar;111(3):378-388
Journal of biomedical materials research. Part A 2023 Mar;111(3):378-388
Cardioprotective and anti-inflammatory effects of Caveolin 1 in experimental diabetic cardiomyopathy.
Gong W, Jiao Q, Yuan J, Luo H, Liu Y, Zhang Y, Chen Z, Xu X, Bai L, Zhang X
Clinical science (London, England : 1979) 2023 Mar 31;137(6):511-525
Clinical science (London, England : 1979) 2023 Mar 31;137(6):511-525
Sustainably released nanoparticle-based rhynchophylline limits pulmonary fibrosis by inhibiting the TEK-PI3K/AKT signaling pathway.
Wang S, Huang Z, Liu Y, Sun H, Zhou Y, Shi J
Translational lung cancer research 2023 Mar 31;12(3):427-445
Translational lung cancer research 2023 Mar 31;12(3):427-445
Combination of pioglitazone, a PPARγ agonist, and synthetic surfactant B-YL prevents hyperoxia-induced lung injury in adult mice lung explants.
Kurihara C, Sakurai R, Chuang TD, Waring AJ, Walther FJ, Rehan VK
Pulmonary pharmacology & therapeutics 2023 Jun;80:102209
Pulmonary pharmacology & therapeutics 2023 Jun;80:102209
ROS promote hyper-methylation of NDRG2 promoters in a DNMTS-dependent manner: Contributes to the progression of renal fibrosis.
Zhao Y, Fan X, Wang Q, Zhen J, Li X, Zhou P, Lang Y, Sheng Q, Zhang T, Huang T, Zhao Y, Lv Z, Wang R
Redox biology 2023 Jun;62:102674
Redox biology 2023 Jun;62:102674
GPR97 deficiency ameliorates renal interstitial fibrosis in mouse hypertensive nephropathy.
Wu JC, Wang XJ, Zhu JH, Huang XY, Liu M, Qiao Z, Zhang Y, Sun Y, Wang ZY, Zhan P, Zhang T, Hu HL, Liu H, Tang W, Yi F
Acta pharmacologica Sinica 2023 Jun;44(6):1206-1216
Acta pharmacologica Sinica 2023 Jun;44(6):1206-1216
ZNF133 is a potent suppressor in breast carcinogenesis through dampening L1CAM, a driver for tumor progression.
Li L, Wang X, Hu K, Liu X, Qiu L, Bai C, Cui Y, Wang B, Wang Z, Wang H, Cheng R, Hua J, Hai L, Wang M, Liu M, Song Z, Xiao C, Li B
Oncogene 2023 Jun;42(27):2166-2182
Oncogene 2023 Jun;42(27):2166-2182
GYY4137, a H(2)S donor, ameliorates kidney injuries in diabetic mice by modifying renal ROS-associated enzymes.
Chen X, Xiao L, Yu S, Ren Z, Wang W, Jia Y, Liu M, Wang P, Ji D, Yu Y, Wang X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jun;162:114694
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jun;162:114694
Mitochondrial folate pathway regulates myofibroblast differentiation and silica-induced pulmonary fibrosis.
Qu Y, Zhai R, Wang D, Wang Z, Hou G, Wu C, Tang M, Xiao X, Jiao J, Ba Y, Zhou F, Qiu J, Yao W
Journal of translational medicine 2023 Jun 6;21(1):365
Journal of translational medicine 2023 Jun 6;21(1):365
AAV9-Tspyl2 gene therapy retards bleomycin-induced pulmonary fibrosis by modulating downstream TGF-β signaling in mice.
Zhang S, Tong X, Liu S, Huang J, Zhang L, Zhang T, Wang D, Fan H
Cell death & disease 2023 Jun 30;14(6):389
Cell death & disease 2023 Jun 30;14(6):389
GATA zinc finger protein p66β promotes breast cancer cell migration by acting as a co-activator of Snail.
Zou X, Ma L, Zhang Y, Zhang Q, Xu C, Zhang D, Chu Y, Zhang J, Li M, Zhang H, Wang J, Peng C, Wei G, Wu Y, Hou Z, Jia H
Cell death & disease 2023 Jun 28;14(6):382
Cell death & disease 2023 Jun 28;14(6):382
Depletion of CUL4B in macrophages ameliorates diabetic kidney disease via miR-194-5p/ITGA9 axis.
Jin S, Song Y, Zhou L, Jiang W, Qin L, Wang Y, Yu R, Liu Y, Diao Y, Zhang F, Liu K, Li P, Hu H, Jiang B, Tang W, Yi F, Gong Y, Liu G, Sun G
Cell reports 2023 Jun 27;42(6):112550
Cell reports 2023 Jun 27;42(6):112550
PLAGL2 promotes Snail expression and gastric cancer progression via UCA1/miR-145-5p/YTHDF1 axis.
Chen W, He Q, Liu J, Li N, Xiao K, Chen H
Carcinogenesis 2023 Jun 24;44(4):328-340
Carcinogenesis 2023 Jun 24;44(4):328-340
Therapeutic Effects of Long-Term Administration of Tranilast in an Animal Model for the Treatment of Fibroids.
Chuang TD, Munoz L, Quintanilla D, Boos D, Khorram O
International journal of molecular sciences 2023 Jun 21;24(13)
International journal of molecular sciences 2023 Jun 21;24(13)
Genetic lineage tracing reveals stellate cells as contributors to myofibroblasts in pancreas and islet fibrosis.
Wang J, Li T, Zhou Y, Wang X, Carvalho V, Ni C, Li W, Wang Q, Chen Y, Shang Z, Qiu S, Sun Z
iScience 2023 Jun 16;26(6):106988
iScience 2023 Jun 16;26(6):106988
Total flavonoid extract from Dracocephalum moldavica L. improves pulmonary fibrosis by reducing inflammation and inhibiting the hedgehog signaling pathway.
He CH, Lv JM, Khan GJ, Duan H, Wang W, Zhai KF, Zou GA, Aisa HA
Phytotherapy research : PTR 2023 Jul;37(7):2745-2758
Phytotherapy research : PTR 2023 Jul;37(7):2745-2758
Dach1 deficiency drives alveolar epithelium apoptosis in pulmonary fibrosis via modulating C-Jun/Bim activity.
Lu Y, Tang K, Wang S, Tian Z, Fan Y, Li B, Wang M, Zhao J, Xie J
Translational research : the journal of laboratory and clinical medicine 2023 Jul;257:54-65
Translational research : the journal of laboratory and clinical medicine 2023 Jul;257:54-65
Schwann cells regulate tumor cells and cancer-associated fibroblasts in the pancreatic ductal adenocarcinoma microenvironment.
Xue M, Zhu Y, Jiang Y, Han L, Shi M, Su R, Wang L, Xiong C, Wang C, Wang T, Deng S, Wu D, Cao Y, Dong L, Bai F, Zhao S, Deng X, Peng C, Li H, Chen J, Shen B, Jiang L, Chen H
Nature communications 2023 Jul 31;14(1):4600
Nature communications 2023 Jul 31;14(1):4600
Metformin attenuates chronic lung allograft dysfunction: evidence in rat models.
Tian D, Zheng X, Tang H, Huang H, Wang J, Xu L, Li C, Yan H, Yu R, Nan J, Liu M, Guo X, Jian S, Wang T, Deng S, Pu Q, Liu L
Respiratory research 2023 Jul 29;24(1):192
Respiratory research 2023 Jul 29;24(1):192
CXCL17 Attenuates Diesel Exhaust Emissions Exposure-Induced Lung Damage by Regulating Macrophage Function.
Yin Y, Mu C, Wang J, Wang Y, Hu W, Zhu W, Yu X, Hao W, Zheng Y, Li Q, Han W
Toxics 2023 Jul 26;11(8)
Toxics 2023 Jul 26;11(8)
Luteolin inhibits subretinal fibrosis and epithelial-mesenchymal transition in laser-induced mouse model via suppression of Smad2/3 and YAP signaling.
Zhang C, Zhang Y, Hu X, Zhao Z, Chen Z, Wang X, Zhang Z, Jin H, Zhang J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154865
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154865
Fibronectin promotes tumor angiogenesis and progression of non-small-cell lung cancer by elevating WISP3 expression via FAK/MAPK/ HIF-1α axis and activating wnt signaling pathway.
Zhou F, Sun J, Ye L, Jiang T, Li W, Su C, Ren S, Wu F, Zhou C, Gao G
Experimental hematology & oncology 2023 Jul 19;12(1):61
Experimental hematology & oncology 2023 Jul 19;12(1):61
Single-cell RNA sequencing reveals that HSD17B2 in cancer-associated fibroblasts promotes the development and progression of castration-resistant prostate cancer.
Zhang Y, Fan A, Li Y, Liu Z, Yu L, Guo J, Hou J, Li X, Chen W
Cancer letters 2023 Jul 10;566:216244
Cancer letters 2023 Jul 10;566:216244
Tartary buckwheat flavonoids alleviates high-fat diet induced kidney fibrosis in mice by inhibiting MAPK and TGF-β1/Smad signaling pathway.
Liu S, Fu S, Jin Y, Geng R, Li Y, Zhang Y, Liu J, Guo W
Chemico-biological interactions 2023 Jul 1;379:110533
Chemico-biological interactions 2023 Jul 1;379:110533
Quercetin inhibits the amphiregulin/EGFR signaling-mediated renal tubular epithelial-mesenchymal transition and renal fibrosis in obstructive nephropathy.
Wang Q, Wang F, Li X, Ma Z, Jiang D
Phytotherapy research : PTR 2023 Jan;37(1):111-123
Phytotherapy research : PTR 2023 Jan;37(1):111-123
Poly-γ-glutamic acid coating polymeric nanoparticles enhance renal drug distribution and cellular uptake for diabetic nephropathy therapy.
Wang Q, Han S, Zhu Y, Wang G, Chen D
Journal of drug targeting 2023 Jan;31(1):89-99
Journal of drug targeting 2023 Jan;31(1):89-99
Interference of ALOX5 alleviates inflammation and fibrosis in high glucose‑induced renal mesangial cells.
Chen X, Xie H, Liu Y, Ou Q, Deng S
Experimental and therapeutic medicine 2023 Jan;25(1):34
Experimental and therapeutic medicine 2023 Jan;25(1):34
The aggravate role of exosomal circRNA11:120406118|12040782 on macrophage pyroptosis through miR-30b-5p/NLRP3 axis in silica-induced lung fibrosis.
Zhang Q, Ban J, Chang S, Qu H, Chen J, Liu F
International immunopharmacology 2023 Jan;114:109476
International immunopharmacology 2023 Jan;114:109476
Effective-compounds of Jinshui Huanxian formula ameliorates fibroblast activation in pulmonary fibrosis by inhibiting the activation of mTOR signaling.
Li J, Li K, Tian Y, Zhao P, Liu X, Li M, Bai Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;109:154604
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;109:154604
Telocyte-Derived Exosomes Provide an Important Source of Wnts That Inhibits Fibrosis and Supports Regeneration and Repair of Endometrium.
Chen TQ, Wei XJ, Liu HY, Zhan SH, Yang XJ
Cell transplantation 2023 Jan-Dec;32:9636897231212746
Cell transplantation 2023 Jan-Dec;32:9636897231212746
Baicalin prevents fibrosis of human trabecular meshwork cells via inhibiting the MyD88/NF-κB pathway.
Li L, Liu Q, Shi L, Zhou X, Wu W, Wang X, Wang L, Wu Z
European journal of pharmacology 2023 Jan 5;938:175425
European journal of pharmacology 2023 Jan 5;938:175425
Exosomes derived from human adipose mesenchymal stem cells ameliorate hepatic fibrosis by inhibiting PI3K/Akt/mTOR pathway and remodeling choline metabolism.
Zhang Z, Shang J, Yang Q, Dai Z, Liang Y, Lai C, Feng T, Zhong D, Zou H, Sun L, Su Y, Yan S, Chen J, Yao Y, Shi Y, Huang X
Journal of nanobiotechnology 2023 Jan 25;21(1):29
Journal of nanobiotechnology 2023 Jan 25;21(1):29
The miR-103a-3p/TGFBR3 axis regulates TGF-β-induced orbital fibroblast activation and fibrosis in thyroid-eye disease.
Xie B, Xiong W, Zhang F, Wang N, Luo Y, Chen Y, Cao J, Chen Z, Ma C, Chen H
Molecular and cellular endocrinology 2023 Jan 1;559:111780
Molecular and cellular endocrinology 2023 Jan 1;559:111780
A2aR inhibits fibrosis and the EMT process in silicosis by regulating Wnt/β-catenin pathway.
Tian Y, Xia J, Yang G, Li C, Qi Y, Dai K, Wu C, Guo Y, Yao W, Hao C
Ecotoxicology and environmental safety 2023 Jan 1;249:114410
Ecotoxicology and environmental safety 2023 Jan 1;249:114410
VX-765 attenuates silica-induced lung inflammatory injury and fibrosis by modulating alveolar macrophages pyroptosis in mice.
Tao H, Zhao H, Mo A, Shao L, Ge D, Liu J, Hu W, Xu K, Ma Q, Wang W, Wang W, Cao H, Mu M, Tao X, Wang J
Ecotoxicology and environmental safety 2023 Jan 1;249:114359
Ecotoxicology and environmental safety 2023 Jan 1;249:114359
Extracellular HSP90 promotes differentiation of lens epithelial cells to fiber cells by activating LRP1-YAP-PROX1 axis.
Li J, Yu J, Huang W, Sang F, Li J, Ren Y, Huang H, Wang M, Li K, Zhang J, Li H, Cui X, Zhang J, Hu M, Yuan F, Guo W, Zhang F, Mu H, Hu Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Feb;37(2):e22783
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Feb;37(2):e22783
Fyn deficiency inhibits oxidative stress by decreasing c-Cbl-mediated ubiquitination of Sirt1 to attenuate diabetic renal fibrosis.
Li S, Lin Z, Xiao H, Xu Z, Li C, Zeng J, Xie X, Deng L, Huang H
Metabolism: clinical and experimental 2023 Feb;139:155378
Metabolism: clinical and experimental 2023 Feb;139:155378
BMAL1/p53 mediating bronchial epithelial cell autophagy contributes to PM2.5-aggravated asthma.
Chen SJ, Huang Y, Yu F, Feng X, Zheng YY, Li Q, Niu Q, Jiang YH, Zhao LQ, Wang M, Cheng PP, Song LJ, Liang LM, He XL, Xiong L, Xiang F, Wang X, Ma WL, Ye H
Cell communication and signaling : CCS 2023 Feb 20;21(1):39
Cell communication and signaling : CCS 2023 Feb 20;21(1):39
Macrophage-derived GPNMB trapped by fibrotic extracellular matrix promotes pulmonary fibrosis.
Wang J, Zhang X, Long M, Yuan M, Yin J, Luo W, Wang S, Cai Y, Jiang W, Chao J
Communications biology 2023 Feb 2;6(1):136
Communications biology 2023 Feb 2;6(1):136
Mitochondrial dysfunction in macrophages promotes inflammation and suppresses repair after myocardial infarction.
Cai S, Zhao M, Zhou B, Yoshii A, Bugg D, Villet O, Sahu A, Olson GS, Davis J, Tian R
The Journal of clinical investigation 2023 Feb 15;133(4)
The Journal of clinical investigation 2023 Feb 15;133(4)
Stomatin-like protein 2 deficiency exacerbates adverse cardiac remodeling.
Hu Y, Jiang H, Xu Y, Chen G, Fan R, Zhou Y, Liu Y, Yao Y, Liu R, Chen W, Zhang K, Chen X, Wang R, Qiu Z
Cell death discovery 2023 Feb 14;9(1):63
Cell death discovery 2023 Feb 14;9(1):63
RGS1 mediates renal interstitial fibrosis through activation of the inflammatory response.
Lu T, Chen S, Xu J
Archives of biochemistry and biophysics 2023 Dec;750:109744
Archives of biochemistry and biophysics 2023 Dec;750:109744
DLK1 overexpression improves sepsis-induced cardiac dysfunction and fibrosis in mice through the TGF-β1/Smad3 signaling pathway and MMPs.
Zeng N, Jian Z, Xu J, Zheng S, Fan Y, Xiao F
Journal of molecular histology 2023 Dec;54(6):655-664
Journal of molecular histology 2023 Dec;54(6):655-664
Human umbilical cord mesenchymal stem cell exosomes alleviate acute kidney injury by inhibiting pyroptosis in rats and NRK-52E cells.
Wan Y, Yu Y, Yu C, Luo J, Wen S, Shen L, Wei G, Hua Y
Renal failure 2023 Dec;45(1):2221138
Renal failure 2023 Dec;45(1):2221138
LncTUG1 ameliorates renal tubular fibrosis in experimental diabetic nephropathy through the miR-145-5p/dual-specificity phosphatase 6 axis.
Wang T, Cui S, Liu X, Han L, Duan X, Feng S, Zhang S, Li G
Renal failure 2023 Dec;45(1):2173950
Renal failure 2023 Dec;45(1):2173950
LncRNA H19-EZH2 interaction promotes liver fibrosis via reprogramming H3K27me3 profiles.
Li XJ, Zhou F, Li YJ, Xue XY, Qu JR, Fan GF, Liu J, Sun R, Wu JZ, Zheng Q, Liu RP
Acta pharmacologica Sinica 2023 Dec;44(12):2479-2491
Acta pharmacologica Sinica 2023 Dec;44(12):2479-2491
BMAL1 inhibits renal fibrosis and renal interstitial inflammation by targeting the ERK1/2/ELK-1/Egr-1 axis.
Chen W, Zhao S, Xing J, Yu W, Rao T, Zhou X, Ruan Y, Li S, Xia Y, Song T, Zou F, Li W, Cheng F
International immunopharmacology 2023 Dec;125(Pt B):111140
International immunopharmacology 2023 Dec;125(Pt B):111140
Icariside Ⅱ attenuates bleomycin-induced pulmonary fibrosis by modulating macrophage polarization.
Deng L, Ouyang B, Shi H, Yang F, Li S, Xie C, Du W, Hu L, Wei Y, Dong J
Journal of ethnopharmacology 2023 Dec 5;317:116810
Journal of ethnopharmacology 2023 Dec 5;317:116810
TRIOBP modulates β-catenin signaling by regulation of miR-29b in idiopathic pulmonary fibrosis.
Wang L, Zhao W, Xia C, Ma S, Li Z, Wang N, Ding L, Wang Y, Cheng L, Liu H, Yang J, Li Y, Rosas I, Yu G
Cellular and molecular life sciences : CMLS 2023 Dec 29;81(1):13
Cellular and molecular life sciences : CMLS 2023 Dec 29;81(1):13
Targeting AKT induced Ferroptosis through FTO/YTHDF2-dependent GPX4 m6A methylation up-regulating and degradating in colorectal cancer.
Zhang G, Mi W, Wang C, Li J, Zhang Y, Liu N, Jiang M, Jia G, Wang F, Yang G, Zhang L, Wang J, Fu Y, Zhang Y
Cell death discovery 2023 Dec 15;9(1):457
Cell death discovery 2023 Dec 15;9(1):457
Squalene epoxidase promotes breast cancer progression by regulating CCNB1 protein stability.
Tuluhong D, Gao H, Li X, Wang L, Zhu Y, Xu C, Wang J, Li H, Li Q, Wang S
Experimental cell research 2023 Dec 1;433(1):113805
Experimental cell research 2023 Dec 1;433(1):113805
Cell and rat serum, urine and tissue metabolomics analysis elucidates the key pathway changes associated with chronic nephropathy and reveals the mechanism of action of rhein.
Wang L, Yu X, Li H, He D, Zeng S, Xiang Z
Chinese medicine 2023 Dec 1;18(1):158
Chinese medicine 2023 Dec 1;18(1):158
Aquaporin 1 is a prognostic marker and inhibits tumour progression through downregulation of Snail expression in intrahepatic cholangiocarcinoma.
Zhuang MQ, Jiang XL, Liu WD, Xie QH, Wang P, Dong LW, Hu HP, Zhou HB, Zhou YB
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2023 Aug;55(8):1133-1140
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2023 Aug;55(8):1133-1140
Testosterone attenuates senile cavernous fibrosis by regulating TGFβR1 and galectin-1 signaling pathways through miR-22-3p.
Hu Z, Zhang Y, Chen J, Luo M, Wang N, Xiao Y, He Q
Molecular and cellular biochemistry 2023 Aug;478(8):1791-1802
Molecular and cellular biochemistry 2023 Aug;478(8):1791-1802
JMJD3 ablation in myeloid cells confers renoprotection in mice with DOCA/salt-induced hypertension.
Gao Y, Yu W, Song J, Nie J, Cui Z, Wen S, Liu B, Liang H
Hypertension research : official journal of the Japanese Society of Hypertension 2023 Aug;46(8):1934-1948
Hypertension research : official journal of the Japanese Society of Hypertension 2023 Aug;46(8):1934-1948
Connexin32 Promotes the Activation of Foxo3a to Ameliorate Diabetic Nephropathy via Inhibiting the Polyubiquitination and Degradation of Sirt1.
Li S, Xiao H, Sun X, Chen Z, Lin Z, Li C, Zeng J, Xu Z, Cheng Y, Huang H
Antioxidants & redox signaling 2023 Aug;39(4-6):241-261
Antioxidants & redox signaling 2023 Aug;39(4-6):241-261
Neonatal-Tissue-Derived Extracellular Vesicle Therapy (NEXT): A Potent Strategy for Precision Regenerative Medicine.
Lou P, Liu S, Wang Y, Lv K, Zhou X, Li L, Zhang Y, Chen Y, Cheng J, Lu Y, Liu J
Advanced materials (Deerfield Beach, Fla.) 2023 Aug;35(33):e2300602
Advanced materials (Deerfield Beach, Fla.) 2023 Aug;35(33):e2300602
Crosstalk between Interleukin-1 Receptor-Like 1 and Transforming Growth Factor-β Receptor Signaling Promotes Renal Fibrosis.
Zhu X, Lu J, Rao J, Ru D, Gao M, Shi D, Cao K, Wen S, Dai C, Wang X, Mi W, Liu L, Zhou H
The American journal of pathology 2023 Aug;193(8):1029-1045
The American journal of pathology 2023 Aug;193(8):1029-1045
USP25 inhibits renal fibrosis by regulating TGFβ-SMAD signaling pathway in Ang II-induced hypertensive mice.
Zhao Y, Chen X, Lin Y, Li Z, Su X, Fan S, Chen Y, Wang X, Liang G
Biochimica et biophysica acta. Molecular basis of disease 2023 Aug;1869(6):166713
Biochimica et biophysica acta. Molecular basis of disease 2023 Aug;1869(6):166713
NQO1 alleviates renal fibrosis by inhibiting the TLR4/NF-κB and TGF-β/Smad signaling pathways in diabetic nephropathy.
Qiu D, Song S, Chen N, Bian Y, Yuan C, Zhang W, Duan H, Shi Y
Cellular signalling 2023 Aug;108:110712
Cellular signalling 2023 Aug;108:110712
T Follicular Helper Cells in Tertiary Lymphoid Structure Contribute to Renal Fibrosis by IL-21.
Luo R, Chang D, Zhang N, Cheng Y, Ge S, Xu G
International journal of molecular sciences 2023 Aug 8;24(16)
International journal of molecular sciences 2023 Aug 8;24(16)
Inhibition of miR-25 Ameliorates Cardiac Dysfunction and Fibrosis by Restoring Krüppel-like Factor 4 Expression.
Lee C, Cho S, Jeong D
International journal of molecular sciences 2023 Aug 4;24(15)
International journal of molecular sciences 2023 Aug 4;24(15)
Biocompatibility and efficacy of prostatic urethral lift in benign prostate hyperplasia: an in vivo and in vitro study.
Xia Y, Yuan T, Zou W, Li H, Ning J, Ruan Y, Xu L, Yu W, Cheng F
Scientific reports 2023 Aug 24;13(1):13828
Scientific reports 2023 Aug 24;13(1):13828
Knockdown of long noncoding RNA SAN rejuvenates aged adipose-derived stem cells via miR-143-3p/ADD3 axis.
Xiong H, Ren S, Chen J, Yang X, Liu Y, Xu Z, Guo J, Jiang T, Yuan M, Liu Y, Zhang G, Li W, Machens HG, Chen Z
Stem cell research & therapy 2023 Aug 21;14(1):213
Stem cell research & therapy 2023 Aug 21;14(1):213
UCP1 alleviates renal interstitial fibrosis progression through oxidative stress pathway mediated by SIRT3 protein stability.
Xiong W, Xiong Z, Song A, Lei C, Ye C, Su H, Zhang C
Journal of translational medicine 2023 Aug 2;21(1):521
Journal of translational medicine 2023 Aug 2;21(1):521
Lenvatinib inhibited HCC cell migration and invasion through regulating the transcription and ubiquitination of UHRF1 and DNMT1.
Fang T, Jiao Z, You Y, Cao J, Wang C, Liu J, Zhao W
Biochemical pharmacology 2023 Apr;210:115489
Biochemical pharmacology 2023 Apr;210:115489
Qianjin Wenwu decoction suppresses renal interstitial fibrosis by enhancing the degradation of extracellular matrix in mice with unilateral ureteral obstruction.
Jin C, Wu X, You Y, Wang Y, Wu J, Zuo A, Zheng Y, Guo J
Chinese journal of natural medicines 2023 Apr;21(4):253-262
Chinese journal of natural medicines 2023 Apr;21(4):253-262
Characterization of myeloid signature genes for predicting prognosis and immune landscape in Ewing sarcoma.
Zhang Z, Shi Y, Zhu Z, Fu J, Liu D, Liu X, Dang J, Tao H, Fan H
Cancer science 2023 Apr;114(4):1240-1255
Cancer science 2023 Apr;114(4):1240-1255
Two-Pore-Domain Potassium Channel TREK-1 Mediates Pulmonary Fibrosis through Macrophage M2 Polarization and by Direct Promotion of Fibroblast Differentiation.
Zhang Y, Fu J, Han Y, Feng D, Yue S, Zhou Y, Luo Z
Biomedicines 2023 Apr 26;11(5)
Biomedicines 2023 Apr 26;11(5)
Neural and central mechanisms of kidney fibrosis after relief of ureteral obstruction.
Su H, Yang Z, Zhang Y, Yang B, Zhou Z, Su C, Cao W
iScience 2023 Apr 21;26(4):106338
iScience 2023 Apr 21;26(4):106338
CEBPD is a master transcriptional factor for hypoxia regulated proteins in glioblastoma and augments hypoxia induced invasion through extracellular matrix-integrin mediated EGFR/PI3K pathway.
Mao XG, Xue XY, Lv R, Ji A, Shi TY, Chen XY, Jiang XF, Zhang X
Cell death & disease 2023 Apr 14;14(4):269
Cell death & disease 2023 Apr 14;14(4):269
FGF18 promotes human lung branching morphogenesis through regulating mesenchymal progenitor cells.
Danopoulos S, Belgacemi R, Hein RFC, Miller AJ, Deutsch GH, Glass I, Spence JR, Al Alam D
American journal of physiology. Lung cellular and molecular physiology 2023 Apr 1;324(4):L433-L444
American journal of physiology. Lung cellular and molecular physiology 2023 Apr 1;324(4):L433-L444
Senescent renal tubular epithelial cells activate fibroblasts by secreting Shh to promote the progression of diabetic kidney disease.
Wang D, Yin L, Chen R, Tan W, Liang L, Xiang J, Zhang H, Zhou X, Deng H, Guo B, Wang Y
Frontiers in medicine 2022;9:1018298
Frontiers in medicine 2022;9:1018298
Peroxisome Proliferator-Activated Receptor Gene Knockout Promotes Podocyte Injury in Diabetic Mice.
Yan R, Zhang Y, Yang Y, Liu L, Liu L, Guo Z, Yu H, Wang Y, Guo B
BioMed research international 2022;2022:9018379
BioMed research international 2022;2022:9018379
Blockage of Fibronectin 1 Ameliorates Myocardial Ischemia/Reperfusion Injury in Association with Activation of AMP-LKB1-AMPK Signaling Pathway.
Zhang YL, Li PB, Han X, Zhang B, Li HH
Oxidative medicine and cellular longevity 2022;2022:6196173
Oxidative medicine and cellular longevity 2022;2022:6196173
Shenxian-Shengmai Oral Liquid Evoke Autophagy of Fibroblast to Attenuate Sinoatrial Node Fibrosis in Sick Sinus Syndrome Mice via the AKT/mTOR Pathway.
Chen C, Zhang H, Hou S, Liu Y, Ren L, Hao M, Chen K, Li L, Cai X, Deng Z, Liu Z, Hou P
Evidence-based complementary and alternative medicine : eCAM 2022;2022:5219277
Evidence-based complementary and alternative medicine : eCAM 2022;2022:5219277
Panax Notoginseng Saponins Regulate Transforming Growth Factor-β1 through MAPK and Snail/TWIST1 Signaling Pathway to Inhibit Epithelial-Mesenchymal Transition of Pulmonary Fibrosis in A549 Cells.
Nguyen V, Pan F, Zhang G, Zhang Q, Lu Y
Evidence-based complementary and alternative medicine : eCAM 2022;2022:3744618
Evidence-based complementary and alternative medicine : eCAM 2022;2022:3744618
Poly (ADP-ribose) polymerase 1 (PARP1) inhibition promotes pulmonary metastasis of osteosarcoma by boosting ezrin phosphorylation.
Li F, Wu X, Fu X, Liu J, Song W, Xiao GG, Lu A, Zhang G
International journal of biological sciences 2022;18(3):1238-1253
International journal of biological sciences 2022;18(3):1238-1253
NR4A1 inhibits the epithelial-mesenchymal transition of hepatic stellate cells: Involvement of TGF-β-Smad2/3/4-ZEB signaling.
Huang Q, Xu J, Ge Y, Shi Y, Wang F, Zhu M
Open life sciences 2022;17(1):447-454
Open life sciences 2022;17(1):447-454
Endoglin aggravates peritoneal fibrosis by regulating the activation of TGF-β/ALK/Smads signaling.
Huang Q, Xiao R, Lu J, Zhang Y, Xu L, Gao J, Sun J, Wang H
Frontiers in pharmacology 2022;13:973182
Frontiers in pharmacology 2022;13:973182
Inhibition of calpain9 attenuates peritoneal dialysis-related peritoneal fibrosis.
Li F, Wang Y, Tian J, Zhou Z, Yin W, Qin X, Wang H, Zeng T, Li A, Jiang J
Frontiers in pharmacology 2022;13:962770
Frontiers in pharmacology 2022;13:962770
Yi-Shen-Hua-Shi Granule Alleviates Adriamycin-Induced Glomerular Fibrosis by Suppressing the BMP2/Smad Signaling Pathway.
Tan Z, Si Y, Yu Y, Ding J, Huang L, Xu Y, Zhang H, Lu Y, Wang C, Yu B, Yuan L
Frontiers in pharmacology 2022;13:917428
Frontiers in pharmacology 2022;13:917428
ATP-citrate lyase inhibitor improves ectopic lipid accumulation in the kidney in a db/db mouse model.
Zhan Z, Li A, Zhang W, Wu X, He J, Li Z, Li Y, Sun J, Zhang H
Frontiers in endocrinology 2022;13:914865
Frontiers in endocrinology 2022;13:914865
Fraxin Promotes the Activation of Nrf2/ARE Pathway via Increasing the Expression of Connexin43 to Ameliorate Diabetic Renal Fibrosis.
Chen R, Zeng J, Li C, Xiao H, Li S, Lin Z, Huang K, Shen J, Huang H
Frontiers in pharmacology 2022;13:853383
Frontiers in pharmacology 2022;13:853383
Gentiopicroside Ameliorates Diabetic Renal Tubulointerstitial Fibrosis via Inhibiting the AT1R/CK2/NF-κB Pathway.
Xu Z, Zhang M, Wang Y, Chen R, Xu S, Sun X, Yang Y, Lin Z, Wang S, Huang H
Frontiers in pharmacology 2022;13:848915
Frontiers in pharmacology 2022;13:848915
Dihydromyricetin Alleviates Pulmonary Fibrosis by Regulating Abnormal Fibroblasts Through the STAT3/p-STAT3/GLUT1 Signaling Pathway.
Li Z, Geng J, Xie B, He J, Wang J, Peng L, Hu Y, Dai H, Wang C
Frontiers in pharmacology 2022;13:834604
Frontiers in pharmacology 2022;13:834604
Atorvastatin Restores PPARα Inhibition of Lipid Metabolism Disorders by Downregulating miR-21 Expression to Improve Mitochondrial Function and Alleviate Diabetic Nephropathy Progression.
Xiang J, Zhang H, Zhou X, Wang D, Chen R, Tan W, Liang L, Shi M, Zhang F, Xiao Y, Zhou Y, Wang Y, Guo B
Frontiers in pharmacology 2022;13:819787
Frontiers in pharmacology 2022;13:819787
Decreased RNA m(6)A methylation enhances the process of the epithelial mesenchymal transition and vasculogenic mimicry in glioblastoma.
Tao M, Li X, He L, Rong X, Wang H, Pan J, Lu Z, Zhang X, Peng Y
American journal of cancer research 2022;12(2):893-906
American journal of cancer research 2022;12(2):893-906
Nintedanib enhances the efficacy of PD-L1 blockade by upregulating MHC-I and PD-L1 expression in tumor cells.
Tu J, Xu H, Ma L, Li C, Qin W, Chen X, Yi M, Sun L, Liu B, Yuan X
Theranostics 2022;12(2):747-766
Theranostics 2022;12(2):747-766
Blockade of phosphotyrosine pathways suggesting SH2 superbinder as a novel therapy for pulmonary fibrosis.
Wang M, Liu AD, Niu Q, Feng X, Zheng YY, Chen SJ, Xu H, Li Q, Hou GQ, Bi XY, Lu YZ, Cheng PP, Liang LM, Jiang YH, Zhao LQ, Liu F, Song LJ, Zhou LL, Xiao LY, Chen F, Li SS, Ma WL, Cao X, Ye H
Theranostics 2022;12(10):4513-4535
Theranostics 2022;12(10):4513-4535
Establishment and characterization of an immortalized epithelial cell line from human gallbladder.
Wang Z, Wang S, Jia Z, Zhao Y, Yang M, Yan W, Chen T, Xiang D, Shao R, Liu Y
Frontiers in oncology 2022;12:994087
Frontiers in oncology 2022;12:994087
Chordin-Like 1 Regulates Epithelial-to-Mesenchymal Transition and Metastasis via the MAPK Signaling Pathway in Oral Squamous Cell Carcinoma.
Wu Q, Zheng Z, Zhang J, Piao Z, Xin M, Xiang X, Wu A, Zhao T, Huang S, Qiao Y, Zhou J, Xu S, Cheng H, Wu L, Ouyang K
Frontiers in oncology 2022;12:862751
Frontiers in oncology 2022;12:862751
ATP11A promotes EMT by regulating Numb PRR(L) in pancreatic cancer cells.
Chen L, Tang J, Sheng W, Sun J, Ma Y, Dong M
PeerJ 2022;10:e13172
PeerJ 2022;10:e13172
Long Noncoding RNA CTD-2589M5.4 Inhibits Ovarian Cancer Cell Proliferation, Migration, and Invasion Via Downregulation of the Extracellular Matrix-Receptor Interaction Pathway.
Gu Y, Huang K, Zhang M, Teng F, Ge L, Zhou J, Xu J, Jia X
Cancer biotherapy & radiopharmaceuticals 2022 Sep;37(7):580-588
Cancer biotherapy & radiopharmaceuticals 2022 Sep;37(7):580-588
Imatinib inhibits pericyte-fibroblast transition and inflammation and promotes axon regeneration by blocking the PDGF-BB/PDGFRβ pathway in spinal cord injury.
Yao F, Luo Y, Liu YC, Chen YH, Li YT, Hu XY, You XY, Yu SS, Li ZY, Chen L, Tian DS, Zheng MG, Cheng L, Jing JH
Inflammation and regeneration 2022 Sep 26;42(1):44
Inflammation and regeneration 2022 Sep 26;42(1):44
PKM2 promotes pulmonary fibrosis by stabilizing TGF-β1 receptor I and enhancing TGF-β1 signaling.
Gao S, Li X, Jiang Q, Liang Q, Zhang F, Li S, Zhang R, Luan J, Zhu J, Gu X, Xiao T, Huang H, Chen S, Ning W, Yang G, Yang C, Zhou H
Science advances 2022 Sep 23;8(38):eabo0987
Science advances 2022 Sep 23;8(38):eabo0987
miR-124- and let-7-Mediated Reprogram of Human Fibroblasts into SST Interneurons.
Gu X, Wang J, Jiang X
ACS chemical neuroscience 2022 Sep 21;13(18):2755-2765
ACS chemical neuroscience 2022 Sep 21;13(18):2755-2765
RO4929097, a Selective γ-Secretase Inhibitor, Inhibits Subretinal Fibrosis Via Suppressing Notch and ERK1/2 Signaling in Laser-Induced Mouse Model.
Zhang C, Qin S, Xie H, Qiu Q, Wang H, Zhang J, Luo D, Zhang J
Investigative ophthalmology & visual science 2022 Sep 1;63(10):14
Investigative ophthalmology & visual science 2022 Sep 1;63(10):14
The Apelin-APJ axis alleviates LPS-induced pulmonary fibrosis and endothelial mesenchymal transformation in mice by promoting Angiotensin-Converting Enzyme 2.
Wang H, Cong L, Yin X, Zhang N, Zhu M, Sun T, Fan J, Xue F, Fan X, Gong Y
Cellular signalling 2022 Oct;98:110418
Cellular signalling 2022 Oct;98:110418
HC-1119, a deuterated Enzalutamide, inhibits Migration, Invasion and Metastasis of the AR-positive triple-negative breast Cancer cells.
Wu X, Feng W, Yang M, Liu X, Gao M, Li X, Gan L, He T
Molecular biology reports 2022 Oct;49(10):9231-9240
Molecular biology reports 2022 Oct;49(10):9231-9240
Anti-inflammatory potential of stevia residue extract against uric acid-associated renal injury in mice.
Mehmood A, Althobaiti F, Zhao L, Usman M, Chen X, Alharthi F, Soliman MM, Shah AA, Murtaza MA, Nadeem M, Ranjha MMAN, Wang C
Journal of food biochemistry 2022 Oct;46(10):e14286
Journal of food biochemistry 2022 Oct;46(10):e14286
Sestrin2 attenuates renal damage by regulating Hippo pathway in diabetic nephropathy.
Bian Y, Shi C, Song S, Mu L, Wu M, Qiu D, Dong J, Zhang W, Yuan C, Wang D, Zhou Z, Dong X, Shi Y
Cell and tissue research 2022 Oct;390(1):93-112
Cell and tissue research 2022 Oct;390(1):93-112
A network pharmacology-based study on the mechanism of astragaloside IV alleviating renal fibrosis through the AKT1/GSK-3β pathway.
Yu X, Xiao Q, Yu X, Cheng Y, Lin H, Xiang Z
Journal of ethnopharmacology 2022 Oct 28;297:115535
Journal of ethnopharmacology 2022 Oct 28;297:115535
Molecular Regulation of Heme Oxygenase-1 Expression by E2F Transcription Factor 2 in Lung Fibroblast Cells: Relevance to Idiopathic Pulmonary Fibrosis.
Ye Q, Taleb SJ, Wang H, Parinandi NL, Kass DJ, Rojas M, Wang C, Ma Q, Zhao J, Zhao Y
Biomolecules 2022 Oct 21;12(10)
Biomolecules 2022 Oct 21;12(10)
RNF2 mediates pulmonary fibroblasts activation and proliferation by regulating mTOR and p16-CDK4-Rb1 signaling pathway.
Pan L, Hu Y, Qian C, Yao Y, Wang S, Shi W, Xu T
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2022 Nov;71(10-11):1283-1303
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2022 Nov;71(10-11):1283-1303
Critical role of PAFR/YAP1 positive feedback loop in cardiac fibrosis.
Li TY, Su W, Li LL, Zhao XG, Yang N, Gai JX, Lv X, Zhang J, Huang MQ, Zhang Q, Ji WH, Song XY, Zhou YH, Li XL, Shan HL, Liang HH
Acta pharmacologica Sinica 2022 Nov;43(11):2862-2872
Acta pharmacologica Sinica 2022 Nov;43(11):2862-2872
Endophilin A2 protects against renal fibrosis by targeting TGF-β/Smad signaling.
Mai X, Shang J, Chen Q, Gu S, Hong Y, Zhou J, Zhang M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Nov;36(11):e22603
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Nov;36(11):e22603
Apigenin inhibits fibrous scar formation after acute spinal cord injury through TGFβ/SMADs signaling pathway.
Jin Z, Tian L, Zhang Y, Zhang X, Kang J, Dong H, Huang N, Pan L, Ning B
CNS neuroscience & therapeutics 2022 Nov;28(11):1883-1894
CNS neuroscience & therapeutics 2022 Nov;28(11):1883-1894
Si-Wu-Tang ameliorates bile duct ligation-induced liver fibrosis via modulating immune environment.
Ma Z, Xue X, Bai J, Cai Y, Jin X, Jia K, Ding M, Lyu X, Li X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Nov;155:113834
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Nov;155:113834
Lysophosphatidylcholine acyltransferase 1 alleviates silica-induced pulmonary fibrosis by modulating lipid metabolism.
Deng X, Hao C, Li Y, Guo Y, Si H, He J, Deng M, Niu Z, Wang C, Xu X, Dai K, Yao W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Nov;155:113638
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Nov;155:113638
Blockade of the pentraxin 3/CD44 interaction attenuates lung injury-induced fibrosis.
Chi JY, Hsiao YW, Liang HY, Huang TH, Chen FW, Chen CY, Ko CY, Cheng CC, Wang JM
Clinical and translational medicine 2022 Nov;12(11):e1099
Clinical and translational medicine 2022 Nov;12(11):e1099
Intracellular hydroxyproline imprinting following resolution of bleomycin-induced pulmonary fibrosis.
Song S, Fu Z, Guan R, Zhao J, Yang P, Li Y, Yin H, Lai Y, Gong G, Zhao S, Yu J, Peng X, He Y, Luo Y, Zhong N, Su J
The European respiratory journal 2022 May;59(5)
The European respiratory journal 2022 May;59(5)
Single-Cell RNA Sequencing Technology Revealed the Pivotal Role of Fibroblast Heterogeneity in Angiotensin II-Induced Abdominal Aortic Aneurysms.
Weng Y, Lou J, Bao Y, Cai C, Zhu K, Du C, Chen X, Tang L
DNA and cell biology 2022 May;41(5):498-520
DNA and cell biology 2022 May;41(5):498-520
Clusterin as a serum biomarker candidate contributes to the lung fibroblasts activation in chronic obstructive pulmonary disease.
Zhang Q, Yue Y, Zheng R
Chinese medical journal 2022 May 5;135(9):1076-1086
Chinese medical journal 2022 May 5;135(9):1076-1086
Asiatic acid from Cyclocarya paliurus regulates the autophagy-lysosome system via directly inhibiting TGF-β type I receptor and ameliorates diabetic nephropathy fibrosis.
Zhang XX, Liu Y, Xu SS, Yang R, Jiang CH, Zhu LP, Xu YY, Pan K, Zhang J, Yin ZQ
Food & function 2022 May 23;13(10):5536-5546
Food & function 2022 May 23;13(10):5536-5546
Reversing insufficient photothermal therapy-induced tumor relapse and metastasis by regulating cancer-associated fibroblasts.
Li X, Yong T, Wei Z, Bie N, Zhang X, Zhan G, Li J, Qin J, Yu J, Zhang B, Gan L, Yang X
Nature communications 2022 May 19;13(1):2794
Nature communications 2022 May 19;13(1):2794
Human epididymis protein 4 aggravates airway inflammation and remodeling in chronic obstructive pulmonary disease.
Zhan Y, Chen J, Wu J, Gu Y, Huang Q, Deng Z, Chen S, Wu X, Lv Y, Zeng Z, Xie J
Respiratory research 2022 May 12;23(1):120
Respiratory research 2022 May 12;23(1):120
Drug-eluting intraocular lens with sustained bromfenac release for conquering posterior capsular opacification.
Zhang X, Lai K, Li S, Wang J, Li J, Wang W, Ni S, Lu B, Grzybowski A, Ji J, Han H, Yao K
Bioactive materials 2022 Mar;9:343-357
Bioactive materials 2022 Mar;9:343-357
Selenium Deficiency Leads to Changes in Renal Fibrosis Marker Proteins and Wnt/β-Catenin Signaling Pathway Components.
Lin T, Tao J, Chen Y, Zhang Y, Li F, Zhang Y, Han X, Zhao Z, Liu G, Li H
Biological trace element research 2022 Mar;200(3):1127-1139
Biological trace element research 2022 Mar;200(3):1127-1139
Malfunction of airway basal stem cells plays a crucial role in pathophysiology of tracheobronchopathia osteoplastica.
Hong Y, Shan S, Gu Y, Huang H, Zhang Q, Han Y, Dong Y, Liu Z, Huang M, Ren T
Nature communications 2022 Mar 14;13(1):1309
Nature communications 2022 Mar 14;13(1):1309
A rapid and simple procedure for the isolation and cultivation of fibroblast-like cells from medaka and zebrafish embryos and fin clip biopsies.
Beedgen L, Hüllen A, Gücüm S, Thumberger T, Wittbrodt J, Thiel C
Laboratory animals 2022 Jun;56(3):270-278
Laboratory animals 2022 Jun;56(3):270-278
Atorvastatin reduces IOP in ocular hypertension in vivo and suppresses ECM in trabecular meshwork perhaps via FGD4.
Song XY, Chen YY, Liu WT, Cong L, Zhang JL, Zhang Y, Zhang YY
International journal of molecular medicine 2022 Jun;49(6)
International journal of molecular medicine 2022 Jun;49(6)
Schwann cell‑like cells derived from human amniotic mesenchymal stem cells promote sciatic nerve repair through an exosome‑induced SOX2/FN1 pathway in vitro.
Chen W, Chang S, Yang C, Zhou J, Zhang H, Nie K, Wei Z
International journal of molecular medicine 2022 Jun;49(6)
International journal of molecular medicine 2022 Jun;49(6)
CHIR99021 balance TGFβ1 induced human corneal endothelial-to-mesenchymal transition to favor corneal endothelial cell proliferation.
Wang Y, Jin C, Tian H, Xu J, Chen J, Hu S, Li Q, Lu L, Ou Q, Xu GT, Cui H
Experimental eye research 2022 Jun;219:108939
Experimental eye research 2022 Jun;219:108939
IL-33 Promotes ST2-Dependent Fibroblast Maturation via P38 and TGF-β in a Mouse Model of Epidural Fibrosis.
Wang H, Wu T, Hua F, Sun J, Bai Y, Wang W, Liu J, Zhang M
Tissue engineering and regenerative medicine 2022 Jun;19(3):577-588
Tissue engineering and regenerative medicine 2022 Jun;19(3):577-588
The miRNA-34a/Sirt1/p53 pathway in a rat model of lens regeneration.
Bi X, Wang R, Song H, Wang Y, Hao P, Li X
Annals of translational medicine 2022 Jun;10(11):636
Annals of translational medicine 2022 Jun;10(11):636
Novel Thermosensitive Hydrogel Promotes Spinal Cord Repair by Regulating Mitochondrial Function.
Li Y, Yang L, Hu F, Xu J, Ye J, Liu S, Wang L, Zhuo M, Ran B, Zhang H, Ye J, Xiao J
ACS applied materials & interfaces 2022 Jun 8;14(22):25155-25172
ACS applied materials & interfaces 2022 Jun 8;14(22):25155-25172
Single-Cell Transcriptomic Analysis of the Mouse Pancreas: Characteristic Features of Pancreatic Ductal Cells in Chronic Pancreatitis.
Mao X, Mao S, Wang L, Jiang H, Deng S, Wang Y, Ye J, Li Z, Zou W, Liao Z
Genes 2022 Jun 5;13(6)
Genes 2022 Jun 5;13(6)
Systematic analyses identify the anti-fibrotic role of lncRNA TP53TG1 in IPF.
Sun J, Guo Y, Chen T, Jin T, Ma L, Ai L, Guo J, Niu Z, Yang R, Wang Q, Yu X, Gao H, Zhang Y, Su W, Song X, Ji W, Zhang Q, Huang M, Fan X, Du Z, Liang H
Cell death & disease 2022 Jun 4;13(6):525
Cell death & disease 2022 Jun 4;13(6):525
Human amniotic fluid mesenchymal stem cells attenuate pancreatic cancer cell proliferation and tumor growth in an orthotopic xenograft mouse model.
Chen YC, Lan YW, Huang SM, Yen CC, Chen W, Wu WJ, Staniczek T, Chong KY, Chen CM
Stem cell research & therapy 2022 Jun 3;13(1):235
Stem cell research & therapy 2022 Jun 3;13(1):235
A signature of circadian rhythm genes in driving anaplastic thyroid carcinoma malignant progression.
Xu T, Jin T, Lu X, Pan Z, Tan Z, Zheng C, Liu Y, Hu X, Ba L, Ren H, Chen J, Zhu C, Ge M, Huang P
Cellular signalling 2022 Jul;95:110332
Cellular signalling 2022 Jul;95:110332
Gankyrin modulated non-small cell lung cancer progression via glycolysis metabolism in a YAP1-dependent manner.
Yu T, Liu Y, Xue J, Sun X, Zhu D, Ma L, Guo Y, Jin T, Cao H, Chen Y, Zhu T, Li X, Liang H, Du Z, Shan H
Cell death discovery 2022 Jul 9;8(1):312
Cell death discovery 2022 Jul 9;8(1):312
Reprogramming of Rat Fibroblasts into Induced Neurons by Small-Molecule Compounds In Vitro and In Vivo.
Wang X, Wu J, Wang W, Zhang Y, He D, Xiao B, Zhang H, Song A, Xing Y, Li B
ACS chemical neuroscience 2022 Jul 20;13(14):2099-2109
ACS chemical neuroscience 2022 Jul 20;13(14):2099-2109
Identification of the active compounds and functional mechanisms of Jinshui Huanxian formula in pulmonary fibrosis by integrating serum pharmacochemistry with network pharmacology.
Shao D, Liu X, Wu J, Zhang A, Bai Y, Zhao P, Li J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jul 20;102:154177
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jul 20;102:154177
ZEB2/TWIST1/PRMT5/NuRD Multicomplex Contributes to the Epigenetic Regulation of EMT and Metastasis in Colorectal Carcinoma.
Zheng Y, Dai M, Dong Y, Yu H, Liu T, Feng X, Yu B, Zhang H, Wu J, Kong W, Yu X, Wu H
Cancers 2022 Jul 14;14(14)
Cancers 2022 Jul 14;14(14)
Hexavalent chromium triggers hepatocytes premature senescence via the GATA4/NF-κB signaling pathway mediated by the DNA damage response.
Ma Y, Li S, Ye S, Hu D, Wei L, Xiao F
Ecotoxicology and environmental safety 2022 Jul 1;239:113645
Ecotoxicology and environmental safety 2022 Jul 1;239:113645
Collagen has a unique SEC24 preference for efficient export from the endoplasmic reticulum.
Lu CL, Ortmeier S, Brudvig J, Moretti T, Cain J, Boyadjiev SA, Weimer JM, Kim J
Traffic (Copenhagen, Denmark) 2022 Jan;23(1):81-93
Traffic (Copenhagen, Denmark) 2022 Jan;23(1):81-93
Doxorubicin promotes breast cancer cell migration and invasion via DCAF13.
Sun Z, Zhou D, Yang J, Zhang D
FEBS open bio 2022 Jan;12(1):221-230
FEBS open bio 2022 Jan;12(1):221-230
AIM2 inflammasome contributes to aldosterone-induced renal injury via endoplasmic reticulum stress.
Wu Y, Yang H, Xu S, Cheng M, Gu J, Zhang W, Liu S, Zhang M
Clinical science (London, England : 1979) 2022 Jan 14;136(1):103-120
Clinical science (London, England : 1979) 2022 Jan 14;136(1):103-120
Identification of Pyruvate Carboxylase as the Cellular Target of Natural Bibenzyls with Potent Anticancer Activity against Hepatocellular Carcinoma via Metabolic Reprogramming.
Sheng Y, Chen Y, Zeng Z, Wu W, Wang J, Ma Y, Lin Y, Zhang J, Huang Y, Li W, Zhu Q, Wei X, Li S, Wisanwattana W, Li F, Liu W, Suksamrarn A, Zhang G, Jiao W, Wang F
Journal of medicinal chemistry 2022 Jan 13;65(1):460-484
Journal of medicinal chemistry 2022 Jan 13;65(1):460-484
Overexpression of bone morphogenetic protein receptor type 2 suppresses transforming growth factor β-induced profibrotic responses in lung fibroblasts.
Fukihara J, Maiolo S, Kovac J, Sakamoto K, Wakahara K, Hashimoto N, Reynolds PN
Experimental lung research 2022 Feb;48(1):35-51
Experimental lung research 2022 Feb;48(1):35-51
Connexin32 ameliorates epithelial-to-mesenchymal-transition in diabetic renal tubular via inhibiting NOX4.
Sun X, Xiao H, Li S, Chen R, Lin Z, Yang Y, Chen Z, Deng L, Huang H
Pharmacological research 2022 Feb;176:106084
Pharmacological research 2022 Feb;176:106084
Norepinephrine promotes glioma cell migration through up-regulating the expression of Twist1.
Wang X, Wang Y, Xie F, Song ZT, Zhang ZQ, Zhao Y, Wang SD, Hu H, Zhang YS, Qian LJ
BMC cancer 2022 Feb 26;22(1):213
BMC cancer 2022 Feb 26;22(1):213
Numb-PRRL promotes TGF-β1- and EGF-induced epithelial-to-mesenchymal transition in pancreatic cancer.
Sheng W, Tang J, Cao R, Shi X, Ma Y, Dong M
Cell death & disease 2022 Feb 23;13(2):173
Cell death & disease 2022 Feb 23;13(2):173
The HDAC2/SP1/miR-205 feedback loop contributes to tubular epithelial cell extracellular matrix production in diabetic kidney disease.
Zheng Z, Zhang S, Chen J, Zou M, Yang Y, Lu W, Ren S, Wang X, Dong W, Zhang Z, Wang L, Guan M, Cheing GLY, Xue Y, Jia Y
Clinical science (London, England : 1979) 2022 Feb 11;136(3):223-238
Clinical science (London, England : 1979) 2022 Feb 11;136(3):223-238
Necroptosis in pulmonary macrophages promotes silica-induced inflammation and interstitial fibrosis in mice.
Tao H, Zhao H, Ge D, Liao J, Shao L, Mo A, Hu L, Xu K, Wu J, Mu M, Li B, Tao X, Wang J
Toxicology letters 2022 Feb 1;355:150-159
Toxicology letters 2022 Feb 1;355:150-159
Baicalin protects against renal interstitial fibrosis in mice by inhibiting the TGF-β/Smad signalling pathway.
Wang H, Jiang Q, Zhang L
Pharmaceutical biology 2022 Dec;60(1):1407-1416
Pharmaceutical biology 2022 Dec;60(1):1407-1416
Improving the circulation time and renal therapeutic potency of extracellular vesicles using an endogenous ligand binding strategy.
Liu S, Lv K, Wang Y, Lou P, Zhou P, Wang C, Li L, Liao G, Zhang Y, Chen Y, Cheng J, Lu Y, Liu J
Journal of controlled release : official journal of the Controlled Release Society 2022 Dec;352:1009-1023
Journal of controlled release : official journal of the Controlled Release Society 2022 Dec;352:1009-1023
Carbon dots enhance extracellular matrix secretion for dentin-pulp complex regeneration through PI3K/Akt/mTOR pathway-mediated activation of autophagy.
Liu L, Li X, Bu W, Jin N, Meng Y, Wang Y, Wang D, Xu X, Zhou D, Sun H
Materials today. Bio 2022 Dec;16:100344
Materials today. Bio 2022 Dec;16:100344
Astrocyte-derived sEVs alleviate fibrosis and promote functional recovery after spinal cord injury in rats.
Lu Y, Chen C, Wang H, Du R, Ji J, Xu T, Yang C, Chen X
International immunopharmacology 2022 Dec;113(Pt A):109322
International immunopharmacology 2022 Dec;113(Pt A):109322
Zanubrutinib attenuates bleomycin-induced pulmonary fibrosis by inhibiting the TGF-β1 signaling pathway.
Chen S, Wei Y, Li S, Miao Y, Gu J, Cui Y, Liu Z, Liang J, Wei L, Li X, Zhou H, Yang C
International immunopharmacology 2022 Dec;113(Pt A):109316
International immunopharmacology 2022 Dec;113(Pt A):109316
TIPARP is involved in the regulation of intraocular pressure.
Zhang Y, Song M, Bi Y, Lei Y, Sun X, Chen Y
Communications biology 2022 Dec 19;5(1):1386
Communications biology 2022 Dec 19;5(1):1386
Metformin Improves Burn Wound Healing by Modulating Microenvironmental Fibroblasts and Macrophages.
Shi L, Jiang Z, Li J, Lin H, Xu B, Liao X, Fu Z, Ao H, Guo G, Liu M
Cells 2022 Dec 16;11(24)
Cells 2022 Dec 16;11(24)
Macrophages regulate vascular smooth muscle cell function during atherosclerosis progression through IL-1β/STAT3 signaling.
Xue Y, Luo M, Hu X, Li X, Shen J, Zhu W, Huang L, Hu Y, Guo Y, Liu L, Wang L, Luo S
Communications biology 2022 Dec 1;5(1):1316
Communications biology 2022 Dec 1;5(1):1316
Tetramethylpyrazine prevents liver fibrotic injury in mice by targeting hepatocyte-derived and mitochondrial DNA-enriched extracellular vesicles.
Li YJ, Liu RP, Ding MN, Zheng Q, Wu JZ, Xue XY, Gu YQ, Ma BN, Cai YJ, Li S, Lin S, Zhang LY, Li X
Acta pharmacologica Sinica 2022 Aug;43(8):2026-2041
Acta pharmacologica Sinica 2022 Aug;43(8):2026-2041
Ferrostatin‑1 alleviates oxalate‑induced renal tubular epithelial cell injury, fibrosis and calcium oxalate stone formation by inhibiting ferroptosis.
Xie J, Ye Z, Li L, Xia Y, Yuan R, Ruan Y, Zhou X
Molecular medicine reports 2022 Aug;26(2)
Molecular medicine reports 2022 Aug;26(2)
Krill Oil Turns Off TGF-β1 Profibrotic Signaling in the Prevention of Diabetic Nephropathy.
Sun X, Yang Y, Sun X, Meng H, Hao W, Yin J, Ma F, Guo X, Du L, Sun L, Wu H
Journal of agricultural and food chemistry 2022 Aug 17;70(32):9865-9876
Journal of agricultural and food chemistry 2022 Aug 17;70(32):9865-9876
Tubular epithelial cell-derived extracellular vesicles induce macrophage glycolysis by stabilizing HIF-1α in diabetic kidney disease.
Jia Y, Chen J, Zheng Z, Tao Y, Zhang S, Zou M, Yang Y, Xue M, Hu F, Li Y, Zhang Q, Xue Y, Zheng Z
Molecular medicine (Cambridge, Mass.) 2022 Aug 12;28(1):95
Molecular medicine (Cambridge, Mass.) 2022 Aug 12;28(1):95
Comparison of Gene Expression Patterns in Articular Cartilage and Xiphoid Cartilage.
Yao B, Zhou Z, Zhang M, Leng X, Zhao D
Biochemical genetics 2022 Apr;60(2):676-706
Biochemical genetics 2022 Apr;60(2):676-706
Inhibition of RUNX1 blocks the differentiation of lung fibroblasts to myofibroblasts.
Dubey S, Dubey PK, Umeshappa CS, Ghebre YT, Krishnamurthy P
Journal of cellular physiology 2022 Apr;237(4):2169-2182
Journal of cellular physiology 2022 Apr;237(4):2169-2182
Botox-A improve the thyroid-associated ophthalmopathy (TAO) orbital fibroblast activation through inhibiting the TGF-β/Smad signaling.
Qi X, Luo B, Deng M, Cao J, Hou S, Xie Z, Tong B, Xiong W
Experimental eye research 2022 Apr;217:108971
Experimental eye research 2022 Apr;217:108971
Exosomes from human adipose-derived mesenchymal stem cells inhibit production of extracellular matrix in keloid fibroblasts via downregulating transforming growth factor-β2 and Notch-1 expression.
Li J, Li Z, Wang S, Bi J, Huo R
Bioengineered 2022 Apr;13(4):8515-8525
Bioengineered 2022 Apr;13(4):8515-8525
Cigarette smoke-induced oxidative stress activates NRF2 to mediate fibronectin disorganization in vascular formation.
Xue J, Liao Q, Luo M, Hua C, Zhao J, Yu G, Chen X, Li X, Zhang X, Ran R, Lu F, Wang Y, Qiao L
Open biology 2022 Apr;12(4):210310
Open biology 2022 Apr;12(4):210310
SU16f inhibits fibrotic scar formation and facilitates axon regeneration and locomotor function recovery after spinal cord injury by blocking the PDGFRβ pathway.
Li Z, Yu S, Liu Y, Hu X, Li Y, Xiao Z, Chen Y, Tian D, Xu X, Cheng L, Zheng M, Jing J
Journal of neuroinflammation 2022 Apr 16;19(1):95
Journal of neuroinflammation 2022 Apr 16;19(1):95
Hexachlorophene, a selective SHP2 inhibitor, suppresses proliferation and metastasis of KRAS-mutant NSCLC cells by inhibiting RAS/MEK/ERK and PI3K/AKT signaling pathways.
Fu NJ, Xi RY, Shi XK, Li RZ, Zhang ZH, Li LY, Zhang GL, Wang F
Toxicology and applied pharmacology 2022 Apr 15;441:115988
Toxicology and applied pharmacology 2022 Apr 15;441:115988
Integrin β3 Induction Promotes Tubular Cell Senescence and Kidney Fibrosis.
Li S, Jiang S, Zhang Q, Jin B, Lv D, Li W, Zhao M, Jiang C, Dai C, Liu Z
Frontiers in cell and developmental biology 2021;9:733831
Frontiers in cell and developmental biology 2021;9:733831
Mesenchymal Stem Cells With Cancer-Associated Fibroblast-Like Phenotype Stimulate SDF-1/CXCR4 Axis to Enhance the Growth and Invasion of B-Cell Acute Lymphoblastic Leukemia Cells Through Cell-to-Cell Communication.
Pan C, Fang Q, Liu P, Ma D, Cao S, Zhang L, Chen Q, Hu T, Wang J
Frontiers in cell and developmental biology 2021;9:708513
Frontiers in cell and developmental biology 2021;9:708513
Mechanically Activated Calcium Channel PIEZO1 Modulates Radiation-Induced Epithelial-Mesenchymal Transition by Forming a Positive Feedback With TGF-β1.
Huang JQ, Zhang H, Guo XW, Lu Y, Wang SN, Cheng B, Dong SH, Lyu XL, Li FS, Li YW
Frontiers in molecular biosciences 2021;8:725275
Frontiers in molecular biosciences 2021;8:725275
Tubular cell-derived exosomal miR-150-5p contributes to renal fibrosis following unilateral ischemia-reperfusion injury by activating fibroblast in vitro and in vivo.
Zhou X, Zhao S, Li W, Ruan Y, Yuan R, Ning J, Jiang K, Xie J, Yao X, Li H, Li C, Rao T, Yu W, Cheng F
International journal of biological sciences 2021;17(14):4021-4033
International journal of biological sciences 2021;17(14):4021-4033
NEDD4L-induced β-catenin ubiquitination suppresses the formation and progression of interstitial pulmonary fibrosis via inhibiting the CTHRC1/HIF-1α axis.
Chen L, Yang Y, Yan H, Peng X, Zou J
International journal of biological sciences 2021;17(13):3320-3330
International journal of biological sciences 2021;17(13):3320-3330
Sympathetic Denervation Ameliorates Renal Fibrosis via Inhibition of Cellular Senescence.
Li Q, Deng Y, Liu L, Zhang C, Cai Y, Zhang T, Han M, Xu G
Frontiers in immunology 2021;12:823935
Frontiers in immunology 2021;12:823935
Ferulic Acid Ameliorates Hepatic Inflammation and Fibrotic Liver Injury by Inhibiting PTP1B Activity and Subsequent Promoting AMPK Phosphorylation.
Wu J, Xue X, Fan G, Gu Y, Zhou F, Zheng Q, Liu R, Li Y, Ma B, Li S, Huang G, Ma L, Li X
Frontiers in pharmacology 2021;12:754976
Frontiers in pharmacology 2021;12:754976
The Extracellular Matrix Enriched With Exosomes for the Treatment on Pulmonary Fibrosis in Mice.
Yu Y, Liu X, Zhao Z, Xu Z, Qiao Y, Zhou Y, Qiao H, Zhong J, Dai J, Suo G
Frontiers in pharmacology 2021;12:747223
Frontiers in pharmacology 2021;12:747223
Transcriptome-Based Network Analysis Reveals Hirudin Potentiates Anti-Renal Fibrosis Efficacy in UUO Rats.
Yu HX, Lin W, Yang K, Wei LJ, Chen JL, Liu XY, Zhong K, Chen X, Pei M, Yang HT
Frontiers in pharmacology 2021;12:741801
Frontiers in pharmacology 2021;12:741801
Berberine Reduces Lipid Accumulation by Promoting Fatty Acid Oxidation in Renal Tubular Epithelial Cells of the Diabetic Kidney.
Rong Q, Han B, Li Y, Yin H, Li J, Hou Y
Frontiers in pharmacology 2021;12:729384
Frontiers in pharmacology 2021;12:729384
Mefunidone Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Mice.
Han Y, Jiang M, He R, Lv X, Liao X, He Y, Zhang F, Long L, Jiang G, Peng Z, Tao L, Hu G, Meng J
Frontiers in pharmacology 2021;12:713572
Frontiers in pharmacology 2021;12:713572
Binding of Plasminogen to Streptococcus suis Protein Endopeptidase O Facilitates Evasion of Innate Immunity in Streptococcus suis.
Zhou Y, Yan K, Sun C, Liu F, Peng W, Chen H, Yuan F, Bei W, Li J
Frontiers in microbiology 2021;12:694103
Frontiers in microbiology 2021;12:694103
ShenLian Extract Enhances TGF-β Functions in the Macrophage-SMC Unit and Stabilizes Atherosclerotic Plaques.
Liu L, Li Q, Yin J, Zhao Z, Sun L, Ran Q, Du X, Wang Y, Li Y, Yang Q, Chen Y, Weng X, Cai W, Zhu X
Frontiers in pharmacology 2021;12:669730
Frontiers in pharmacology 2021;12:669730
Ameliorative Effects of Osthole on Experimental Renal Fibrosis in vivo and in vitro by Inhibiting IL-11/ERK1/2 Signaling.
Wu F, Zhao Y, Shao Q, Fang K, Dong R, Jiang S, Lu F, Luo J, Chen G
Frontiers in pharmacology 2021;12:646331
Frontiers in pharmacology 2021;12:646331
Exosomal miR-500a-5p derived from cancer-associated fibroblasts promotes breast cancer cell proliferation and metastasis through targeting USP28.
Chen B, Sang Y, Song X, Zhang D, Wang L, Zhao W, Liang Y, Zhang N, Yang Q
Theranostics 2021;11(8):3932-3947
Theranostics 2021;11(8):3932-3947
Exosomal miR-21 from tubular cells contributes to renal fibrosis by activating fibroblasts via targeting PTEN in obstructed kidneys.
Zhao S, Li W, Yu W, Rao T, Li H, Ruan Y, Yuan R, Li C, Ning J, Li S, Chen W, Cheng F, Zhou X
Theranostics 2021;11(18):8660-8673
Theranostics 2021;11(18):8660-8673
Local administration of liposomal-based Srpx2 gene therapy reverses pulmonary fibrosis by blockading fibroblast-to-myofibroblast transition.
Wang Q, Liu J, Hu Y, Pan T, Xu Y, Yu J, Xiong W, Zhou Q, Wang Y
Theranostics 2021;11(14):7110-7125
Theranostics 2021;11(14):7110-7125
The NEAT1_2/miR-491 Axis Modulates Papillary Thyroid Cancer Invasion and Metastasis Through TGM2/NFκb/FN1 Signaling.
Sun W, Qin Y, Wang Z, Dong W, He L, Zhang T, Zhang H
Frontiers in oncology 2021;11:610547
Frontiers in oncology 2021;11:610547
miR-23a-3p regulates the inflammatory response and fibrosis in diabetic kidney disease by targeting early growth response 1.
Sheng S, Zou M, Yang Y, Guan M, Ren S, Wang X, Wang L, Xue Y
In vitro cellular & developmental biology. Animal 2021 Sep;57(8):763-774
In vitro cellular & developmental biology. Animal 2021 Sep;57(8):763-774
Use of Platelet-Rich Plasma Plus Suramin, an Antifibrotic Agent, to Improve Muscle Healing After Injuries.
Tsai WC, Yu TY, Chang GJ, Chang HN, Lin LP, Lin MS, Pang JS
The American journal of sports medicine 2021 Sep;49(11):3102-3112
The American journal of sports medicine 2021 Sep;49(11):3102-3112
Exercise training ameliorates early diabetic kidney injury by regulating the H(2) S/SIRT1/p53 pathway.
Yang L, Li DX, Cao BQ, Liu SJ, Xu DH, Zhu XY, Liu YJ
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Sep;35(9):e21823
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Sep;35(9):e21823
Presegetane diterpenoids from Euphorbia sieboldiana as a new type of anti-liver fibrosis agents that inhibit TGF-β/Smad signaling pathway.
Li S, Gan L, Tian YJ, Tian Y, Fan RZ, Huang D, Yuan FY, Zhang X, Lin Y, Zhu QF, Tang GH, Yan XL, Yin S
Bioorganic chemistry 2021 Sep;114:105222
Bioorganic chemistry 2021 Sep;114:105222
MiR-192-5p inhibits proliferation, migration, and invasion in papillary thyroid carcinoma cells by regulation of SH3RF3.
Fu S, Ma C, Tang X, Ma X, Jing G, Zhao N, Ran J
Bioscience reports 2021 Sep 30;41(9)
Bioscience reports 2021 Sep 30;41(9)
KLF15 negatively regulates cardiac fibrosis by which SDF-1β attenuates cardiac fibrosis in type 2 diabetic mice.
Tian Y, Wang Z, Zheng X, Song W, Cai L, Rane M, Zhao Y
Toxicology and applied pharmacology 2021 Sep 15;427:115654
Toxicology and applied pharmacology 2021 Sep 15;427:115654
MIER3 induces epithelial-mesenchymal transition and promotes breast cancer cell aggressiveness via forming a co-repressor complex with HDAC1/HDAC2/Snail.
Huang W, Chen J, Liu X, Liu X, Duan S, Chen L, Liu X, Lan J, Zou Y, Guo D, Zhou J
Experimental cell research 2021 Sep 1;406(1):112722
Experimental cell research 2021 Sep 1;406(1):112722
A novel in vitro assay for peripheral nerve-related cell migration that preserves both extracellular matrix-derived molecular cues and nanofiber-derived topography.
Achenbach P, Hambeukers I, Pierling AL, Gerardo-Nava JL, Hillerbrand L, Sechi AS, Glücks KJ, Dalton PD, Pich A, Dievernich A, Altinova H, Brook GA
Journal of neuroscience methods 2021 Sep 1;361:109289
Journal of neuroscience methods 2021 Sep 1;361:109289
Interleukin-7 Is Associated with Clinical and Pathological Activities in Immunoglobulin A Nephropathy and Protects the Renal Proximal Tubule Epithelium from Cellular Fibrosis.
Deng YJ, Lin XP, Li XQ, Lu PF, Cai Y, Liu LL, Pei GC, Han M
Current medical science 2021 Oct;41(5):880-887
Current medical science 2021 Oct;41(5):880-887
The long non-coding RNA PFI protects against pulmonary fibrosis by interacting with splicing regulator SRSF1.
Sun J, Jin T, Su W, Guo Y, Niu Z, Guo J, Li L, Wang J, Ma L, Yu T, Li X, Zhou Y, Shan H, Liang H
Cell death and differentiation 2021 Oct;28(10):2916-2930
Cell death and differentiation 2021 Oct;28(10):2916-2930
Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors.
Xia W, Xie J, Cai Z, Liu X, Wen J, Cui ZK, Zhao R, Zhou X, Chen J, Mao X, Gu Z, Zou Z, Zou Z, Zhang Y, Zhao M, Mac M, Song Q, Bai X
Nature communications 2021 Oct 15;12(1):6043
Nature communications 2021 Oct 15;12(1):6043
Triiodothyronine ameliorates silica-induced pulmonary inflammation and fibrosis in mice.
Yang M, Wang D, Gan S, Wang B, Yu L, Xie Y, Fan L, Ma J, Chen W
The Science of the total environment 2021 Oct 10;790:148041
The Science of the total environment 2021 Oct 10;790:148041
Maiwei Yangfei decoction prevents bleomycin-induced pulmonary fibrosis in mice.
Xu Y, Peng W, Han D, Feng F, Wang Z, Gu C, Zhou X, Wu Q
Experimental and therapeutic medicine 2021 Nov;22(5):1306
Experimental and therapeutic medicine 2021 Nov;22(5):1306
Injectable self-assembling peptide nanofiber hydrogel as a bioactive 3D platform to promote chronic wound tissue regeneration.
Lou P, Liu S, Wang Y, Pan C, Xu X, Zhao M, Liao G, Yang G, Yuan Y, Li L, Zhang J, Chen Y, Cheng J, Lu Y, Liu J
Acta biomaterialia 2021 Nov;135:100-112
Acta biomaterialia 2021 Nov;135:100-112
Si-Wu-Tang ameliorates fibrotic liver injury via modulating intestinal microbiota and bile acid homeostasis.
Xue X, Wu J, Ding M, Gao F, Zhou F, Xu B, Lu M, Li J, Li X
Chinese medicine 2021 Nov 4;16(1):112
Chinese medicine 2021 Nov 4;16(1):112
Drug-containing serum of rhubarb-astragalus capsule inhibits the epithelial-mesenchymal transformation of HK-2 by downregulating TGF-β1/p38MAPK/Smad2/3 pathway.
Qin MY, Huang SQ, Zou XQ, Zhong XB, Yang YF, Zhang YT, Mi ZC, Zhang YS, Huang ZG
Journal of ethnopharmacology 2021 Nov 15;280:114414
Journal of ethnopharmacology 2021 Nov 15;280:114414
MPP7 promotes the migration and invasion of breast cancer cells via EGFR/AKT signaling.
Liao W, Fan L, Li M, Deng H, Yang A, Liu F
Cell biology international 2021 May;45(5):948-956
Cell biology international 2021 May;45(5):948-956
Fibronectin-integrin signaling regulates PLVAP localization at endothelial fenestrae by microtubule stabilization.
Nakakura T, Suzuki T, Horiguchi K, Tanaka H, Arisawa K, Miyashita T, Nekooki-Machida Y, Hagiwara H
Cell and tissue research 2021 May;384(2):449-463
Cell and tissue research 2021 May;384(2):449-463
miR-509-3p Suppresses Migration, Invasion, and Epithelial- Mesenchymal Transition in Melanoma Cells by Targeting Collagen Triple Helix Repeat Containing 1.
Yuan K, Sun Y, Ji Y
Balkan medical journal 2021 May;38(3):177-182
Balkan medical journal 2021 May;38(3):177-182
Improved response of human gingival fibroblasts to titanium coated with micro-/nano-structured tantalum.
Zhang CN, Zhou LY, Qian SJ, Gu YX, Shi JY, Lai HC
International journal of implant dentistry 2021 May 3;7(1):36
International journal of implant dentistry 2021 May 3;7(1):36
A HIF1A/miR-485-5p/SRPK1 axis modulates the aggressiveness of glioma cells upon hypoxia.
Cheng L, Peng R, Guo P, Zhang H, Liu D, Liao X, Liu Y, Mo X, Liao Y
Experimental cell research 2021 May 1;402(1):112547
Experimental cell research 2021 May 1;402(1):112547
Glucagon-like peptide-1 (GLP-1) improved diabetic lung fibrosis via AMPK and microRNA-27a (miR-27a).
Liu J, Li X, Lu S, Zheng X, Zhang X, Zhao W
Annals of translational medicine 2021 Mar;9(6):492
Annals of translational medicine 2021 Mar;9(6):492
Dopamine receptor D2 inhibition alleviates diabetic hepatic stellate cells fibrosis by regulating the TGF-β1/Smads and NFκB pathways.
Zhao B, Li S, Guo Z, Chen Z, Zhang X, Xu C, Chen J, Wei C
Clinical and experimental pharmacology & physiology 2021 Mar;48(3):370-380
Clinical and experimental pharmacology & physiology 2021 Mar;48(3):370-380
miR‑106b‑5p targeting SIX1 inhibits TGF‑β1‑induced pulmonary fibrosis and epithelial‑mesenchymal transition in asthma through regulation of E2F1.
Liu S, Chen X, Zhang S, Wang X, Du X, Chen J, Zhou G
International journal of molecular medicine 2021 Mar;47(3)
International journal of molecular medicine 2021 Mar;47(3)
KLF4 initiates sustained YAP activation to promote renal fibrosis in mice after ischemia-reperfusion kidney injury.
Xu D, Chen PP, Zheng PQ, Yin F, Cheng Q, Zhou ZL, Xie HY, Li JY, Ni JY, Wang YZ, Chen SJ, Zhou L, Wang XX, Liu J, Zhang W, Lu LM
Acta pharmacologica Sinica 2021 Mar;42(3):436-450
Acta pharmacologica Sinica 2021 Mar;42(3):436-450
Aptamer-SH2 superbinder-based targeted therapy for pancreatic ductal adenocarcinoma.
Liu AD, Zhou J, Bi XY, Hou GQ, Li SS, Chen Q, Xu H, Cao X
Clinical and translational medicine 2021 Mar;11(3):e337
Clinical and translational medicine 2021 Mar;11(3):e337
pH-Sensitive Nanoparticles Composed Solely of Membrane-Disruptive Macromolecules for Treating Pancreatic Cancer.
Fan F, Jin L, Yang L
ACS applied materials & interfaces 2021 Mar 24;13(11):12824-12835
ACS applied materials & interfaces 2021 Mar 24;13(11):12824-12835
The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity.
Chen S, Liu X, Peng C, Tan C, Sun H, Liu H, Zhang Y, Wu P, Cui C, Liu C, Yang D, Li Z, Lu J, Guan J, Ke X, Wang R, Bo X, Xu X, Han J, Liu J
Cell metabolism 2021 Mar 2;33(3):565-580.e7
Cell metabolism 2021 Mar 2;33(3):565-580.e7
Identification and functional analysis of senescence-associated secretory phenotype of premature senescent hepatocytes induced by hexavalent chromium.
Ma Y, Liang Y, Liang N, Zhang Y, Xiao F
Ecotoxicology and environmental safety 2021 Mar 15;211:111908
Ecotoxicology and environmental safety 2021 Mar 15;211:111908
Regulation of connective tissue growth factor expression by miR-133b for the treatment of renal interstitial fibrosis in aged mice with unilateral ureteral obstruction.
Cao D, Wang Y, Zhang Y, Zhang Y, Huang Q, Yin Z, Cai G, Chen X, Sun X
Stem cell research & therapy 2021 Mar 10;12(1):171
Stem cell research & therapy 2021 Mar 10;12(1):171
Inhibition of ER stress by targeting the IRE1α-TXNDC5 pathway alleviates crystalline silica-induced pulmonary fibrosis.
Chen X, Li C, Liu J, He Y, Wei Y, Chen J
International immunopharmacology 2021 Jun;95:107519
International immunopharmacology 2021 Jun;95:107519
USP9X deubiquitinates connexin43 to prevent high glucose-induced epithelial-to-mesenchymal transition in NRK-52E cells.
Sun XH, Xiao HM, Zhang M, Lin ZY, Yang Y, Chen R, Liu PQ, Huang KP, Huang HQ
Biochemical pharmacology 2021 Jun;188:114562
Biochemical pharmacology 2021 Jun;188:114562
STAT3/HIF-1α signaling activation mediates peritoneal fibrosis induced by high glucose.
Yang X, Bao M, Fang Y, Yu X, Ji J, Ding X
Journal of translational medicine 2021 Jun 30;19(1):283
Journal of translational medicine 2021 Jun 30;19(1):283
Mesenchymal stem cells ameliorate silica-induced pulmonary fibrosis by inhibition of inflammation and epithelial-mesenchymal transition.
Wei J, Zhao Q, Yang G, Huang R, Li C, Qi Y, Hao C, Yao W
Journal of cellular and molecular medicine 2021 Jun 2;25(13):6417-28
Journal of cellular and molecular medicine 2021 Jun 2;25(13):6417-28
A Novel Rat Model with Long Range Optic Nerve Injury to Study Retinal Ganglion Cells Endogenous Regeneration.
Zhang S, Liu B, Zhu H, Jin H, Gong Z, Qiu H, Xu M, Chen M, Nan K, Wu W
Neuroscience 2021 Jun 15;465:71-84
Neuroscience 2021 Jun 15;465:71-84
LncRNA CTD-2528L19.6 prevents the progression of IPF by alleviating fibroblast activation.
Chen T, Guo Y, Wang J, Ai L, Ma L, He W, Li Z, Yu X, Li J, Fan X, Gu Y, Liang H
Cell death & disease 2021 Jun 10;12(6):600
Cell death & disease 2021 Jun 10;12(6):600
Pterostilbene alleviates pulmonary fibrosis by regulating ASIC2.
Peng Y, Zhang Y, Zhang Y, Wang X, Xia Y
Chinese medicine 2021 Jul 28;16(1):66
Chinese medicine 2021 Jul 28;16(1):66
GALNT2 promotes cell proliferation, migration, and invasion by activating the Notch/Hes1-PTEN-PI3K/Akt signaling pathway in lung adenocarcinoma.
Wang W, Sun R, Zeng L, Chen Y, Zhang N, Cao S, Deng S, Meng X, Yang S
Life sciences 2021 Jul 1;276:119439
Life sciences 2021 Jul 1;276:119439
Physcion 8-O-β-glucopyranoside ameliorates liver fibrosis through inflammation inhibition by regulating SIRT3-mediated NF-κB P65 nuclear expression.
Chen C, Gu J, Wang J, Wu Y, Yang A, Chen T, Zhou T, Liu Z
International immunopharmacology 2021 Jan;90:107206
International immunopharmacology 2021 Jan;90:107206
Long noncoding RNA EPB41L4A-AS1 functions as an oncogene by regulating the Rho/ROCK pathway in colorectal cancer.
Bin J, Nie S, Tang Z, Kang A, Fu Z, Hu Y, Liao Q, Xiong W, Zhou Y, Tang Y, Jiang J
Journal of cellular physiology 2021 Jan;236(1):523-535
Journal of cellular physiology 2021 Jan;236(1):523-535
Treatment of keloids through Runx2 siRNA‑induced inhibition of the PI3K/AKT signaling pathway.
Lv W, Wu M, Ren Y, Luo X, Hu W, Zhang Q, Wu Y
Molecular medicine reports 2021 Jan;23(1)
Molecular medicine reports 2021 Jan;23(1)
Mitomycin C induces pulmonary vascular endothelial-to-mesenchymal transition and pulmonary veno-occlusive disease via Smad3-dependent pathway in rats.
Zhang C, Lu W, Luo X, Liu S, Li Y, Zheng Q, Liu W, Wu X, Chen Y, Jiang Q, Zhang Z, Gu G, Chen J, Chen H, Liao J, Liu C, Hong C, Tang H, Sun D, Yang K, Wang J
British journal of pharmacology 2021 Jan;178(1):217-235
British journal of pharmacology 2021 Jan;178(1):217-235
Responsive and activable nanomedicines for remodeling the tumor microenvironment.
Zhang Y, Han X, Nie G
Nature protocols 2021 Jan;16(1):405-430
Nature protocols 2021 Jan;16(1):405-430
Anti-renal interstitial fibrosis effect of norcantharidin is exerted through inhibition of PP2Ac-mediated C-terminal phosphorylation of Smad3.
Luo HW, Yin DD, Xiao Z, Wen L, Liao YJ, Tang CY, Zeng D, Xiao HT, Li Y
Chemical biology & drug design 2021 Feb;97(2):293-304
Chemical biology & drug design 2021 Feb;97(2):293-304
Involvement of miR-27a-3p in diabetic nephropathy via affecting renal fibrosis, mitochondrial dysfunction, and endoplasmic reticulum stress.
Wu L, Wang Q, Guo F, Ma X, Wang J, Zhao Y, Yan Y, Qin G
Journal of cellular physiology 2021 Feb;236(2):1454-1468
Journal of cellular physiology 2021 Feb;236(2):1454-1468
Epigallocatechin gallate (EGCG) attenuates myocardial hypertrophy and fibrosis induced by transverse aortic constriction via inhibiting the Akt/mTOR pathway.
Cui Y, Wang Y, Liu G
Pharmaceutical biology 2021 Dec;59(1):1305-1313
Pharmaceutical biology 2021 Dec;59(1):1305-1313
Exosomal ANXA2 derived from ovarian cancer cells regulates epithelial-mesenchymal plasticity of human peritoneal mesothelial cells.
Gao L, Nie X, Gou R, Hu Y, Dong H, Li X, Lin B
Journal of cellular and molecular medicine 2021 Dec;25(23):10916-10929
Journal of cellular and molecular medicine 2021 Dec;25(23):10916-10929
Tissue factor potentiates adherence of breast cancer cells to human umbilical vein endothelial cells under static and flow conditions.
Jin Y, Liu W, Wang F, Wang M, Xu K, Yang A, Wang C, Zhang L, Zhang F, Li M
Cell adhesion & migration 2021 Dec;15(1):74-83
Cell adhesion & migration 2021 Dec;15(1):74-83
Withaferin A protects against hyperuricemia induced kidney injury and its possible mechanisms.
Zhao X, Wang J, Tang L, Li P, Ru J, Bai Y
Bioengineered 2021 Dec;12(1):589-600
Bioengineered 2021 Dec;12(1):589-600
Deficiency of CARMA3 attenuates the development of bleomycin induced pulmonary fibrosis.
Wu Y, Qi Y, Qiu Z, Chen W
Biochemical and biophysical research communications 2021 Dec 3;581:81-88
Biochemical and biophysical research communications 2021 Dec 3;581:81-88
Effects of L-leucine on the properties of spray-dried swellable microparticles with wrinkled surfaces for inhalation therapy of pulmonary fibrosis.
Wang X, Wan W, Lu J, Quan G, Pan X, Liu P
International journal of pharmaceutics 2021 Dec 15;610:121223
International journal of pharmaceutics 2021 Dec 15;610:121223
Heat shock protein 90 inhibitor ameliorates pancreatic fibrosis by degradation of transforming growth factor-β receptor.
Peng YF, Lin H, Liu DC, Zhu XY, Huang N, Wei YX, Li L
Cellular signalling 2021 Aug;84:110001
Cellular signalling 2021 Aug;84:110001
LncRNA-MALAT1/miRNA-204-5p/Smad4 Axis Regulates Epithelial-Mesenchymal Transition, Proliferation and Migration of Lens Epithelial Cells.
Peng C, Wang Y, Ji L, Kuang L, Yu Z, Li H, Zhang J, Zhao J
Current eye research 2021 Aug;46(8):1137-1147
Current eye research 2021 Aug;46(8):1137-1147
IL-1β augments TGF-β inducing epithelial-mesenchymal transition of epithelial cells and associates with poor pulmonary function improvement in neutrophilic asthmatics.
Zhang S, Fan Y, Qin L, Fang X, Zhang C, Yue J, Bai W, Wang G, Chen Z, Renz H, Skevaki C, Liu X, Xie M
Respiratory research 2021 Aug 3;22(1):216
Respiratory research 2021 Aug 3;22(1):216
Adenosine A3 receptor activated in H(2)O(2) oxidative stress of primary open-angle glaucoma.
Zhou Z, Gao Z, Yan W, Zhang Y, Huang J, Xiong K
Annals of translational medicine 2021 Apr;9(7):526
Annals of translational medicine 2021 Apr;9(7):526
Metformin attenuates post-epidural fibrosis by inhibiting the TGF-β1/Smad3 and HMGB1/TLR4 signaling pathways.
Song Z, Wu T, Sun J, Wang H, Hua F, Nicolas YSM, Kc R, Chen K, Jin Z, Liu J, Zhang M
Journal of cellular and molecular medicine 2021 Apr;25(7):3272-3283
Journal of cellular and molecular medicine 2021 Apr;25(7):3272-3283
Astragalus membranaceus and Salvia miltiorrhiza ameliorates cyclosporin A-induced chronic nephrotoxicity through the "gut-kidney axis".
Han C, Jiang YH, Li W, Liu Y
Journal of ethnopharmacology 2021 Apr 6;269:113768
Journal of ethnopharmacology 2021 Apr 6;269:113768
Metformin effectively treats Tsc1 deletion-caused kidney pathology by upregulating AMPK phosphorylation.
Fang Y, Li F, Qi C, Mao X, Wang F, Zhao Z, Chen JK, Zhang Z, Wu H
Cell death discovery 2020;6:52
Cell death discovery 2020;6:52
IL-33-induced neutrophil extracellular traps degrade fibronectin in a murine model of bronchopulmonary dysplasia.
Jin R, Xu J, Gao Q, Mao X, Yin J, Lu K, Guo Y, Zhang M, Cheng R
Cell death discovery 2020;6:33
Cell death discovery 2020;6:33
Transcriptomic Analysis Reveals the Protection of Astragaloside IV against Diabetic Nephropathy by Modulating Inflammation.
Zhang Y, Tao C, Xuan C, Jiang J, Cao W
Oxidative medicine and cellular longevity 2020;2020:9542165
Oxidative medicine and cellular longevity 2020;2020:9542165
Hirudin Ameliorates Renal Interstitial Fibrosis via Regulating TGF-β1/Smad and NF-κB Signaling in UUO Rat Model.
Yang K, Fan B, Zhao Q, Ji Y, Liu P, Gao S, Ren T, Dou Y, Pei M, Yang H
Evidence-based complementary and alternative medicine : eCAM 2020;2020:7291075
Evidence-based complementary and alternative medicine : eCAM 2020;2020:7291075
Withaferin A Exerts Preventive Effect on Liver Fibrosis through Oxidative Stress Inhibition in a Sirtuin 3-Dependent Manner.
Gu J, Chen C, Wang J, Chen T, Yao W, Yan T, Liu Z
Oxidative medicine and cellular longevity 2020;2020:2452848
Oxidative medicine and cellular longevity 2020;2020:2452848
Empagliflozin Protects Against Proximal Renal Tubular Cell Injury Induced by High Glucose via Regulation of Hypoxia-Inducible Factor 1-Alpha.
Ndibalema AR, Kabuye D, Wen S, Li L, Li X, Fan Q
Diabetes, metabolic syndrome and obesity : targets and therapy 2020;13:1953-1967
Diabetes, metabolic syndrome and obesity : targets and therapy 2020;13:1953-1967
Melatonin ameliorates hyperglycaemia-induced renal inflammation by inhibiting the activation of TLR4 and TGF-β1/Smad3 signalling pathway.
Wei J, Wang Y, Qi X, Fan Z, Wu Y
American journal of translational research 2020;12(5):1584-1599
American journal of translational research 2020;12(5):1584-1599
Hyperoside Attenuates Bleomycin-Induced Pulmonary Fibrosis Development in Mice.
Huang J, Tong X, Zhang L, Zhang Y, Wang L, Wang D, Zhang S, Fan H
Frontiers in pharmacology 2020;11:550955
Frontiers in pharmacology 2020;11:550955
Scutellarein inhibits BLM-mediated pulmonary fibrosis by affecting fibroblast differentiation, proliferation, and apoptosis.
Miao K, Pan T, Mou Y, Zhang L, Xiong W, Xu Y, Yu J, Wang Y
Therapeutic advances in chronic disease 2020;11:2040622320940185
Therapeutic advances in chronic disease 2020;11:2040622320940185
Epithelial-Mesenchymal Transition in Asthma Airway Remodeling Is Regulated by the IL-33/CD146 Axis.
Sun Z, Ji N, Ma Q, Zhu R, Chen Z, Wang Z, Qian Y, Wu C, Hu F, Huang M, Zhang M
Frontiers in immunology 2020;11:1598
Frontiers in immunology 2020;11:1598
Andrographolide attenuates epithelial-mesenchymal transition induced by TGF-β1 in alveolar epithelial cells.
Li J, Liu J, Yue W, Xu K, Cai W, Cui F, Li Z, Wang W, He J
Journal of cellular and molecular medicine 2020 Sep;24(18):10501-10511
Journal of cellular and molecular medicine 2020 Sep;24(18):10501-10511
Deubiquitinase USP13 promotes extracellular matrix expression by stabilizing Smad4 in lung fibroblast cells.
Liao X, Li Y, Liu J, Zhang Y, Tan J, Kass DJ, Rojas M, Mallampalli RK, Zhao J, Zhao Y
Translational research : the journal of laboratory and clinical medicine 2020 Sep;223:15-24
Translational research : the journal of laboratory and clinical medicine 2020 Sep;223:15-24
The AKT/GSK3-Mediated Slug Expression Contributes to Oxaliplatin Resistance in Colorectal Cancer via Upregulation of ERCC1.
Wei W, Ma XD, Jiang GM, Shi B, Zhong W, Sun CL, Zhao L, Hou YJ, Wang H
Oncology research 2020 Sep 1;28(4):423-438
Oncology research 2020 Sep 1;28(4):423-438
Deubiquitinase USP29 promotes gastric cancer cell migration by cooperating with phosphatase SCP1 to stabilize Snail protein.
Qian W, Li Q, Wu X, Li W, Li Q, Zhang J, Li M, Zhang D, Zhao H, Zou X, Jia H, Zhang L, Yang XD, Hou Z
Oncogene 2020 Oct;39(44):6802-6815
Oncogene 2020 Oct;39(44):6802-6815
Neutrophil extracellular traps promote scar formation in post-epidural fibrosis.
Jin Z, Sun J, Song Z, Chen K, Nicolas YSM, Kc R, Ma Q, Liu J, Zhang M
NPJ Regenerative medicine 2020 Oct 30;5(1):19
NPJ Regenerative medicine 2020 Oct 30;5(1):19
MAD2B contributes to parietal epithelial cell activation and crescentic glomerulonephritis via Skp2.
Ye C, Xiong W, Lei CT, Tang H, Su H, Yi F, Zhang C
American journal of physiology. Renal physiology 2020 Oct 1;319(4):F636-F646
American journal of physiology. Renal physiology 2020 Oct 1;319(4):F636-F646
MiR-185-5p ameliorates endoplasmic reticulum stress and renal fibrosis by downregulation of ATF6.
Yuan Q, Xu T, Chen Y, Qu W, Sun D, Liu X, Sun L
Laboratory investigation; a journal of technical methods and pathology 2020 Nov;100(11):1436-1446
Laboratory investigation; a journal of technical methods and pathology 2020 Nov;100(11):1436-1446
Sox13 promotes hepatocellular carcinoma metastasis by transcriptionally activating Twist1.
Feng M, Fang F, Fang T, Jiao H, You S, Wang X, Zhao W
Laboratory investigation; a journal of technical methods and pathology 2020 Nov;100(11):1400-1410
Laboratory investigation; a journal of technical methods and pathology 2020 Nov;100(11):1400-1410
TREM2 Alzheimer's variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages.
Hall-Roberts H, Agarwal D, Obst J, Smith TB, Monzón-Sandoval J, Di Daniel E, Webber C, James WS, Mead E, Davis JB, Cowley SA
Alzheimer's research & therapy 2020 Nov 16;12(1):151
Alzheimer's research & therapy 2020 Nov 16;12(1):151
Norcantharidin protects against renal interstitial fibrosis by suppressing TWEAK-mediated Smad3 phosphorylation.
Zeng D, Xiao Z, Xu Q, Luo H, Wen L, Tang C, Shan Y, Tian J, Wei J, Li Y
Life sciences 2020 Nov 1;260:118488
Life sciences 2020 Nov 1;260:118488
Ganoderic acid hinders renal fibrosis via suppressing the TGF-β/Smad and MAPK signaling pathways.
Geng XQ, Ma A, He JZ, Wang L, Jia YL, Shao GY, Li M, Zhou H, Lin SQ, Ran JH, Yang BX
Acta pharmacologica Sinica 2020 May;41(5):670-677
Acta pharmacologica Sinica 2020 May;41(5):670-677
Inhibition of miR-182-5p attenuates pulmonary fibrosis via TGF-β/Smad pathway.
Chen Y, Zhang Q, Zhou Y, Yang Z, Tan M
Human & experimental toxicology 2020 May;39(5):683-695
Human & experimental toxicology 2020 May;39(5):683-695
Ischemia-reperfusion injury of brain induces endothelial-mesenchymal transition and vascular fibrosis via activating let-7i/TGF-βR1 double-negative feedback loop.
Chen D, Li L, Wang Y, Xu R, Peng S, Zhou L, Deng Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 May;34(5):7178-7191
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 May;34(5):7178-7191
Cardamonin retards progression of autosomal dominant polycystic kidney disease via inhibiting renal cyst growth and interstitial fibrosis.
He J, Zhou H, Meng J, Zhang S, Li X, Wang S, Shao G, Jin W, Geng X, Zhu S, Yang B
Pharmacological research 2020 May;155:104751
Pharmacological research 2020 May;155:104751
High-mobility group box 1 promotes epithelial-to-mesenchymal transition in crystalline silica induced pulmonary inflammation and fibrosis.
Ma J, Xu Y, Li W, Zhou Y, Wang D, Yang M, Wang B, Chen W
Toxicology letters 2020 May 17;330:134-143
Toxicology letters 2020 May 17;330:134-143
IRF-1 promotes renal fibrosis by downregulation of Klotho.
Li Y, Liu Y, Huang Y, Yang K, Xiao T, Xiong J, Wang K, Liu C, He T, Yu Y, Han W, Wang Y, Bi X, Zhang J, Huang Y, Zhang B, Zhao J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Mar;34(3):4415-4429
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Mar;34(3):4415-4429
WNT1-inducible signaling protein-1 mediates TGF-β1-induced renal fibrosis in tubular epithelial cells and unilateral ureteral obstruction mouse models via autophagy.
Yang X, Wang H, Tu Y, Li Y, Zou Y, Li G, Wang L, Zhong X
Journal of cellular physiology 2020 Mar;235(3):2009-2022
Journal of cellular physiology 2020 Mar;235(3):2009-2022
A PTAL-miR-101-FN1 Axis Promotes EMT and Invasion-Metastasis in Serous Ovarian Cancer.
Liang H, Yu M, Yang R, Zhang L, Zhang L, Zhu D, Luo H, Hong Y, Yu T, Sun J, Shan H, Gu Y
Molecular therapy oncolytics 2020 Mar 27;16:53-62
Molecular therapy oncolytics 2020 Mar 27;16:53-62
Tartrate-Resistant Acid Phosphatase 5/ACP5 Interacts with p53 to Control the Expression of SMAD3 in Lung Adenocarcinoma.
Hu Y, Yu J, Wang Q, Zhang L, Chen X, Cao Y, Zhao J, Xu Y, Jiang D, Wang Y, Xiong W
Molecular therapy oncolytics 2020 Mar 27;16:272-288
Molecular therapy oncolytics 2020 Mar 27;16:272-288
Monocyte-derived alveolar macrophage apolipoprotein E participates in pulmonary fibrosis resolution.
Cui H, Jiang D, Banerjee S, Xie N, Kulkarni T, Liu RM, Duncan SR, Liu G
JCI insight 2020 Mar 12;5(5)
JCI insight 2020 Mar 12;5(5)
Antisense Oligonucleotide in LNA-Gapmer Design Targeting TGFBR2-A Key Single Gene Target for Safe and Effective Inhibition of TGFβ Signaling.
Kuespert S, Heydn R, Peters S, Wirkert E, Meyer AL, Siebörger M, Johannesen S, Aigner L, Bogdahn U, Bruun TH
International journal of molecular sciences 2020 Mar 12;21(6)
International journal of molecular sciences 2020 Mar 12;21(6)
Long non-coding RNA DBH-AS1 promotes cancer progression in diffuse large B-cell lymphoma by targeting FN1 via RNA-binding protein BUD13.
Song Y, Gao F, Peng Y, Yang X
Cell biology international 2020 Jun;44(6):1331-1340
Cell biology international 2020 Jun;44(6):1331-1340
HMGB1 protein promotes glomerular mesangial matrix deposition via TLR2 in lupus nephritis.
Feng X, Yang R, Tian Y, Miao X, Guo H, Gao F, Yang L, Zhao S, Zhang W, Liu J, Li H, Tian Y, Zhao L, Wang S, Liu W, Wang K, Li Y, Wang Z, Liu Q, Wang C, Liu S
Journal of cellular physiology 2020 Jun;235(6):5111-5119
Journal of cellular physiology 2020 Jun;235(6):5111-5119
RhoJ Regulates α5β1 Integrin Trafficking to Control Fibronectin Remodeling during Angiogenesis.
Sundararaman A, Fukushima Y, Norman JC, Uemura A, Mellor H
Current biology : CB 2020 Jun 8;30(11):2146-2155.e5
Current biology : CB 2020 Jun 8;30(11):2146-2155.e5
Transcriptomic analysis of the mechanisms of alleviating renal interstitial fibrosis using the traditional Chinese medicine Kangxianling in a rat model.
Jiang Y, Zhu Y, Zhen T, Li J, Xing K, He L, Zhu S
Scientific reports 2020 Jun 30;10(1):10682
Scientific reports 2020 Jun 30;10(1):10682
Klotho is regulated by transcription factor Sp1 in renal tubular epithelial cells.
Li Y, Liu Y, Wang K, Huang Y, Han W, Xiong J, Yang K, Liu M, Xiao T, Liu C, He T, Bi X, Zhang J, Zhang B, Zhao J
BMC molecular and cell biology 2020 Jun 22;21(1):45
BMC molecular and cell biology 2020 Jun 22;21(1):45
Modification of PLGA Scaffold by MSC-Derived Extracellular Matrix Combats Macrophage Inflammation to Initiate Bone Regeneration via TGF-β-Induced Protein.
Deng M, Tan J, Hu C, Hou T, Peng W, Liu J, Yu B, Dai Q, Zhou J, Yang Y, Dong R, Ruan C, Dong S, Xu J
Advanced healthcare materials 2020 Jul;9(13):e2000353
Advanced healthcare materials 2020 Jul;9(13):e2000353
LRIG3 represses cell motility by inhibiting slug via inactivating ERK signaling in human colorectal cancer.
Zeng K, Chen X, Xu M, Liu X, Li C, Xu X, Pan B, Qin J, He B, Pan Y, Huiling S, Xu T, Wang S
IUBMB life 2020 Jul;72(7):1393-1403
IUBMB life 2020 Jul;72(7):1393-1403
The effect of lncRNA-ARAP1-AS2/ARAP1 on high glucose-induced cytoskeleton rearrangement and epithelial-mesenchymal transition in human renal tubular epithelial cells.
Li L, Xu L, Wen S, Yang Y, Li X, Fan Q
Journal of cellular physiology 2020 Jul;235(7-8):5787-5795
Journal of cellular physiology 2020 Jul;235(7-8):5787-5795
Connexin 43 prevents the progression of diabetic renal tubulointerstitial fibrosis by regulating the SIRT1-HIF-1α signaling pathway.
Sun X, Huang K, Haiming X, Lin Z, Yang Y, Zhang M, Liu P, Huang H
Clinical science (London, England : 1979) 2020 Jul 17;134(13):1573-1592
Clinical science (London, England : 1979) 2020 Jul 17;134(13):1573-1592
Type I collagen facilitates safe and reliable expansion of human dental pulp stem cells in xenogeneic serum-free culture.
Mochizuki M, Sagara H, Nakahara T
Stem cell research & therapy 2020 Jul 14;11(1):267
Stem cell research & therapy 2020 Jul 14;11(1):267
Phloretin ameliorates hyperuricemia-induced chronic renal dysfunction through inhibiting NLRP3 inflammasome and uric acid reabsorption.
Cui D, Liu S, Tang M, Lu Y, Zhao M, Mao R, Wang C, Yuan Y, Li L, Chen Y, Cheng J, Lu Y, Liu J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 Jan;66:153111
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 Jan;66:153111
miRNA‑342 suppresses renal interstitial fibrosis in diabetic nephropathy by targeting SOX6.
Jiang ZH, Tang YZ, Song HN, Yang M, Li B, Ni CL
International journal of molecular medicine 2020 Jan;45(1):45-52
International journal of molecular medicine 2020 Jan;45(1):45-52
Subcellular trafficking of tubular MDM2 implicates in acute kidney injury to chronic kidney disease transition during multiple low-dose cisplatin exposure.
Su H, Ye C, Lei CT, Tang H, Zeng JY, Yi F, Zhang C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jan;34(1):1620-1636
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jan;34(1):1620-1636
Hydrogen sulfide attenuates cigarette smoke-induced airway remodeling by upregulating SIRT1 signaling pathway.
Guan R, Wang J, Cai Z, Li Z, Wang L, Li Y, Xu J, Li D, Yao H, Liu W, Deng B, Lu W
Redox biology 2020 Jan;28:101356
Redox biology 2020 Jan;28:101356
Celastrol exerts anti-inflammatory effect in liver fibrosis via activation of AMPK-SIRT3 signalling.
Wang Y, Li C, Gu J, Chen C, Duanmu J, Miao J, Yao W, Tao J, Tu M, Xiong B, Zhao L, Liu Z
Journal of cellular and molecular medicine 2020 Jan;24(1):941-953
Journal of cellular and molecular medicine 2020 Jan;24(1):941-953
Connexin32 ameliorates renal fibrosis in diabetic mice by promoting K48-linked NADPH oxidase 4 polyubiquitination and degradation.
Chen Z, Sun X, Chen Q, Lan T, Huang K, Xiao H, Lin Z, Yang Y, Liu P, Huang H
British journal of pharmacology 2020 Jan;177(1):145-160
British journal of pharmacology 2020 Jan;177(1):145-160
Gentiopicroside activates the bile acid receptor Gpbar1 (TGR5) to repress NF-kappaB pathway and ameliorate diabetic nephropathy.
Xiao H, Sun X, Liu R, Chen Z, Lin Z, Yang Y, Zhang M, Liu P, Quan S, Huang H
Pharmacological research 2020 Jan;151:104559
Pharmacological research 2020 Jan;151:104559
Long non-coding RNA RNF7 promotes the cardiac fibrosis in rat model via miR-543/THBS1 axis and TGFβ1 activation.
Ouyang F, Liu X, Liu G, Qiu H, He Y, Hu H, Jiang P
Aging 2020 Jan 8;12(1):996-1010
Aging 2020 Jan 8;12(1):996-1010
GSPE alleviates renal fibrosis by inhibiting the activation of C3/ HMGB1/ TGF-β1 pathway.
Wang K, Wei H, Zhan J, Liang X, Zhang C, Liu Y, Xu G
Chemico-biological interactions 2020 Jan 25;316:108926
Chemico-biological interactions 2020 Jan 25;316:108926
miR-485 suppresses inflammation and proliferation of mesangial cells in an in vitro model of diabetic nephropathy by targeting NOX5.
Wu J, Lu K, Zhu M, Xie X, Ding Y, Shao X, Chen Y, Liu J, Xu M, Xu Y, Zhou J, Shen X, Zhu C
Biochemical and biophysical research communications 2020 Jan 22;521(4):984-990
Biochemical and biophysical research communications 2020 Jan 22;521(4):984-990
Fibroblasts Derived From Human Adipose Stem Cells Produce More Effective Extracellular Matrix and Migrate Faster Compared to Primary Dermal Fibroblasts.
Gersch RP, Raum JC, Calvert C, Percec I
Aesthetic surgery journal 2020 Jan 1;40(1):108-117
Aesthetic surgery journal 2020 Jan 1;40(1):108-117
miR-363-3p inhibits migration, invasion, and epithelial-mesenchymal transition by targeting NEDD9 and SOX4 in non-small-cell lung cancer.
Chang J, Gao F, Chu H, Lou L, Wang H, Chen Y
Journal of cellular physiology 2020 Feb;235(2):1808-1820
Journal of cellular physiology 2020 Feb;235(2):1808-1820
Anti-Adhesive, Platelet Gathering Effects of c-RGD Modified Poly(p-dioxanone-co-l-Phe) Electrospun Membrane and Its Comprehensive Application in Intestinal Anastomosis.
Wang B, Feng C, Dang J, Niu L, Shen C, Yang X, Zhang T, Zhang X
Macromolecular bioscience 2020 Feb;20(2):e1900344
Macromolecular bioscience 2020 Feb;20(2):e1900344
A self-assembling peptide hydrogel-based drug co-delivery platform to improve tissue repair after ischemia-reperfusion injury.
Liu S, Zhao M, Zhou Y, Li L, Wang C, Yuan Y, Li L, Liao G, Bresette W, Chen Y, Cheng J, Lu Y, Liu J
Acta biomaterialia 2020 Feb;103:102-114
Acta biomaterialia 2020 Feb;103:102-114
IL-6 trans-signaling drives a STAT3-dependent pathway that leads to structural alterations of the peritoneal membrane.
Yang X, Yan H, Jiang N, Yu Z, Yuan J, Ni Z, Fang W
American journal of physiology. Renal physiology 2020 Feb 1;318(2):F338-F353
American journal of physiology. Renal physiology 2020 Feb 1;318(2):F338-F353
Polydatin attenuates renal fibrosis in diabetic mice through regulating the Cx32-Nox4 signaling pathway.
Chen ZQ, Sun XH, Li XJ, Xu ZC, Yang Y, Lin ZY, Xiao HM, Zhang M, Quan SJ, Huang HQ
Acta pharmacologica Sinica 2020 Dec;41(12):1587-1596
Acta pharmacologica Sinica 2020 Dec;41(12):1587-1596
Disruption of retinoid homeostasis induces RBP4 overproduction in diabetes: O-GlcNAcylation involved.
Shin SJ, Chen CH, Kuo WC, Chan HC, Chan HC, Lin KD, Ke LY
Metabolism: clinical and experimental 2020 Dec;113:154403
Metabolism: clinical and experimental 2020 Dec;113:154403
Stem-cell-derived ECM sheet-implant complexes for enhancing osseointegration.
Feng Y, Jiang Z, Zhang Y, Miao X, Yu Q, Xie Z, Yang G
Biomaterials science 2020 Dec 7;8(23):6647-6656
Biomaterials science 2020 Dec 7;8(23):6647-6656
Regulation of FN1 degradation by the p62/SQSTM1-dependent autophagy-lysosome pathway in HNSCC.
Liu X, Meng L, Li X, Li D, Liu Q, Chen Y, Li X, Bu W, Sun H
International journal of oral science 2020 Dec 14;12(1):34
International journal of oral science 2020 Dec 14;12(1):34
Transcriptome analysis reveals a protective role of liver X receptor alpha against silica particle-induced experimental silicosis.
Yao W, Yang P, Qi Y, Jin L, Zhao A, Ding M, Wang D, Li Y, Hao C
The Science of the total environment 2020 Dec 10;747:141531
The Science of the total environment 2020 Dec 10;747:141531
Metformin inhibits extracellular matrix accumulation, inflammation and proliferation of mesangial cells in diabetic nephropathy by regulating H19/miR-143-3p/TGF-β1 axis.
Xu J, Xiang P, Liu L, Sun J, Ye S
The Journal of pharmacy and pharmacology 2020 Aug;72(8):1101-1109
The Journal of pharmacy and pharmacology 2020 Aug;72(8):1101-1109
Melatonin Ameliorates Renal Fibrosis Through the Inhibition of NF-κB and TGF-β1/Smad3 Pathways in db/db Diabetic Mice.
Fan Z, Qi X, Yang W, Xia L, Wu Y
Archives of medical research 2020 Aug;51(6):524-534
Archives of medical research 2020 Aug;51(6):524-534
Possible involvement of TGF‑β‑SMAD‑mediated epithelial‑mesenchymal transition in pro‑metastatic property of PAX6.
Jin M, Gao D, Wang R, Sik A, Liu K
Oncology reports 2020 Aug;44(2):555-564
Oncology reports 2020 Aug;44(2):555-564
miR-143 inhibits renal cell carcinoma cells metastatic potential by suppressing ABL2.
Xu B, Wang C, Wang YL, Chen SQ, Wu JP, Zhu WD, Wang CY, Guan H, Guan C, You ZH, Chen M
The Kaohsiung journal of medical sciences 2020 Aug;36(8):592-598
The Kaohsiung journal of medical sciences 2020 Aug;36(8):592-598
Hsa-miR-425-5p promotes tumor growth and metastasis by activating the CTNND1-mediated β-catenin pathway and EMT in colorectal cancer.
Liu D, Zhang H, Cui M, Chen C, Feng Y
Cell cycle (Georgetown, Tex.) 2020 Aug;19(15):1917-1927
Cell cycle (Georgetown, Tex.) 2020 Aug;19(15):1917-1927
Trichostatin A Alleviates Renal Interstitial Fibrosis Through Modulation of the M2 Macrophage Subpopulation.
Tseng WC, Tsai MT, Chen NJ, Tarng DC
International journal of molecular sciences 2020 Aug 19;21(17)
International journal of molecular sciences 2020 Aug 19;21(17)
RIG-I aggravates interstitial fibrosis via c-Myc-mediated fibroblast activation in UUO mice.
Zhou Z, Ni J, Li J, Huo C, Miao N, Yin F, Cheng Q, Xu D, Xie H, Chen P, Zheng P, Zhang Y, Zhou L, Zhang W, Yu C, Liu J, Lu L
Journal of molecular medicine (Berlin, Germany) 2020 Apr;98(4):527-540
Journal of molecular medicine (Berlin, Germany) 2020 Apr;98(4):527-540
LncRNA LINP1 confers tamoxifen resistance and negatively regulated by ER signaling in breast cancer.
Ma T, Liang Y, Li Y, Song X, Zhang N, Li X, Chen B, Zhao W, Wang L, Yang Q
Cellular signalling 2020 Apr;68:109536
Cellular signalling 2020 Apr;68:109536
Micro-vesicles from mesenchymal stem cells over-expressing miR-34a inhibit transforming growth factor-β1-induced epithelial-mesenchymal transition in renal tubular epithelial cells in vitro.
He J, Jiang YL, Wang Y, Tian XJ, Sun SR
Chinese medical journal 2020 Apr 5;133(7):800-807
Chinese medical journal 2020 Apr 5;133(7):800-807
Wu-Mei-Wan ameliorates chronic colitis-associated intestinal fibrosis through inhibiting fibroblast activation.
Wu F, Shao Q, Hu M, Zhao Y, Dong R, Fang K, Xu L, Zou X, Lu F, Li J, Chen G
Journal of ethnopharmacology 2020 Apr 24;252:112580
Journal of ethnopharmacology 2020 Apr 24;252:112580
MicroRNA-183 regulates lipopolysaccharide-induced oxidative stress of hippocampal neurons by targeting the fibronectin 1 gene.
Xie Q, Feng L, Zhang C, Gan L
Neuroscience letters 2020 Apr 23;725:134902
Neuroscience letters 2020 Apr 23;725:134902
Exosomal miR-125a-5p derived from silica-exposed macrophages induces fibroblast transdifferentiation.
Wang D, Hao C, Zhang L, Zhang J, Liu S, Li Y, Qu Y, Zhao Y, Huang R, Wei J, Yao W
Ecotoxicology and environmental safety 2020 Apr 1;192:110253
Ecotoxicology and environmental safety 2020 Apr 1;192:110253
Kidney-targeted rhein-loaded liponanoparticles for diabetic nephropathy therapy via size control and enhancement of renal cellular uptake.
Wang G, Li Q, Chen D, Wu B, Wu Y, Tong W, Huang P
Theranostics 2019;9(21):6191-6208
Theranostics 2019;9(21):6191-6208
FOXO1 Overexpression Attenuates Tubulointerstitial Fibrosis and Apoptosis in Diabetic Kidneys by Ameliorating Oxidative Injury via TXNIP-TRX.
Ji L, Wang Q, Huang F, An T, Guo F, Zhao Y, Liu Y, He Y, Song Y, Qin G
Oxidative medicine and cellular longevity 2019;2019:3286928
Oxidative medicine and cellular longevity 2019;2019:3286928
Stem Cells from Human Exfoliated Deciduous Teeth Ameliorate Diabetic Nephropathy In Vivo and In Vitro by Inhibiting Advanced Glycation End Product-Activated Epithelial-Mesenchymal Transition.
Rao N, Wang X, Xie J, Li J, Zhai Y, Li X, Fang T, Wang Y, Zhao Y, Ge L
Stem cells international 2019;2019:2751475
Stem cells international 2019;2019:2751475
TGF-β1 Induces Epithelial-Mesenchymal Transition of Chronic Sinusitis with Nasal Polyps through MicroRNA-21.
Li X, Li C, Zhu G, Yuan W, Xiao ZA
International archives of allergy and immunology 2019;179(4):304-319
International archives of allergy and immunology 2019;179(4):304-319
Presence and function of stress granules in atrial fibrillation.
Dong G, Liang F, Sun B, Wang C, Liu Y, Guan X, Yang B, Xiu C, Yang N, Liu F, Lu T, Han W
PloS one 2019;14(4):e0213769
PloS one 2019;14(4):e0213769
Development and validation of a novel phonomimetic bioreactor.
Kirsch A, Hortobagyi D, Stachl T, Karbiener M, Grossmann T, Gerstenberger C, Gugatschka M
PloS one 2019;14(3):e0213788
PloS one 2019;14(3):e0213788
CLK3 Is A Direct Target Of miR-144 And Contributes To Aggressive Progression In Hepatocellular Carcinoma.
Li H, Cui X, Hu Q, Chen X, Zhou P
OncoTargets and therapy 2019;12:9201-9213
OncoTargets and therapy 2019;12:9201-9213
Ursolic Acid Treatment Alleviates Diabetic Kidney Injury By Regulating The ARAP1/AT1R Signaling Pathway.
Ma TK, Xu L, Lu LX, Cao X, Li X, Li LL, Wang X, Fan QL
Diabetes, metabolic syndrome and obesity : targets and therapy 2019;12:2597-2608
Diabetes, metabolic syndrome and obesity : targets and therapy 2019;12:2597-2608
A small molecule inhibitor MCC950 ameliorates kidney injury in diabetic nephropathy by inhibiting NLRP3 inflammasome activation.
Zhang C, Zhu X, Li L, Ma T, Shi M, Yang Y, Fan Q
Diabetes, metabolic syndrome and obesity : targets and therapy 2019;12:1297-1309
Diabetes, metabolic syndrome and obesity : targets and therapy 2019;12:1297-1309
Low-molecular-weight fucoidan attenuates bleomycin-induced pulmonary fibrosis: possible role in inhibiting TGF-β1-induced epithelial-mesenchymal transition through ERK pathway.
Wang L, Zhang P, Li X, Zhang Y, Zhan Q, Wang C
American journal of translational research 2019;11(4):2590-2602
American journal of translational research 2019;11(4):2590-2602
Dapagliflozin Attenuates Renal Tubulointerstitial Fibrosis Associated With Type 1 Diabetes by Regulating STAT1/TGFβ1 Signaling.
Huang F, Zhao Y, Wang Q, Hillebrands JL, van den Born J, Ji L, An T, Qin G
Frontiers in endocrinology 2019;10:441
Frontiers in endocrinology 2019;10:441
lncRNA NR_038323 Suppresses Renal Fibrosis in Diabetic Nephropathy by Targeting the miR-324-3p/DUSP1 Axis.
Ge Y, Wang J, Wu D, Zhou Y, Qiu S, Chen J, Zhu X, Xiang X, Li H, Zhang D
Molecular therapy. Nucleic acids 2019 Sep 6;17:741-753
Molecular therapy. Nucleic acids 2019 Sep 6;17:741-753
Germacrane Sesquiterpenoids as a New Type of Anticardiac Fibrosis Agent Targeting Transforming Growth Factor β Type I Receptor.
Lou LL, Ni FQ, Chen L, Shaker S, Li W, Wang R, Tang GH, Yin S
Journal of medicinal chemistry 2019 Sep 12;62(17):7961-7975
Journal of medicinal chemistry 2019 Sep 12;62(17):7961-7975
Plasma fractalkine levels are associated with renal inflammation and outcomes in immunoglobulin A nephropathy.
Luo R, Guo SM, Li YQ, Yang Y, Li ML, Han M, He XF, Ge SW, Xu G
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2019 Sep 1;34(9):1549-1558
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2019 Sep 1;34(9):1549-1558
Pioglitazone attenuates kidney fibrosis via miR-21-5p modulation.
Sun L, Xu T, Chen Y, Qu W, Sun D, Song X, Yuan Q, Yao L
Life sciences 2019 Sep 1;232:116609
Life sciences 2019 Sep 1;232:116609
Potential role of M2 macrophage polarization in ventilator-induced lung fibrosis.
Wang L, Zhang Y, Zhang N, Xia J, Zhan Q, Wang C
International immunopharmacology 2019 Oct;75:105795
International immunopharmacology 2019 Oct;75:105795
FoxO1-mediated inhibition of STAT1 alleviates tubulointerstitial fibrosis and tubule apoptosis in diabetic kidney disease.
Huang F, Wang Q, Guo F, Zhao Y, Ji L, An T, Song Y, Liu Y, He Y, Qin G
EBioMedicine 2019 Oct;48:491-504
EBioMedicine 2019 Oct;48:491-504
TNF-α Regulates ITGβ1 and SYND4 Expression in Nucleus Pulposus Cells: Activation of FAK/PI3K Signaling.
Wu X, Li S, Wang K, Hua W, Li S, Song Y, Zhang Y, Yang S, Yang C
Inflammation 2019 Oct;42(5):1575-1584
Inflammation 2019 Oct;42(5):1575-1584
RNA-Seq analysis of potential lncRNAs and genes for the anti-renal fibrotic effect of norcantharidin.
Xiao H, Liao Y, Tang C, Xiao Z, Luo H, Li J, Liu H, Sun L, Zeng D, Li Y
Journal of cellular biochemistry 2019 Oct;120(10):17354-17367
Journal of cellular biochemistry 2019 Oct;120(10):17354-17367
Rhodojaponin II attenuates kidney injury by regulating TGF-β1/Smad pathway in mice with adriamycin nephropathy.
Qiu Y, Zhou J, Zhang H, Zhou H, Tang H, Lei C, Ye C, You C, Chen Y, Wang Y, Xiong J, Su H, Yao G, Zhang C
Journal of ethnopharmacology 2019 Oct 28;243:112078
Journal of ethnopharmacology 2019 Oct 28;243:112078
NLRP3 inflammasome inhibition attenuates cisplatin-induced renal fibrosis by decreasing oxidative stress and inflammation.
Li S, Lin Q, Shao X, Mou S, Gu L, Wang L, Zhang Z, Shen J, Zhou Y, Qi C, Jin H, Pang H, Ni Z
Experimental cell research 2019 Oct 1;383(1):111488
Experimental cell research 2019 Oct 1;383(1):111488
Genetic loss of Gas6/Mer pathway attenuates silica-induced lung inflammation and fibrosis in mice.
Li W, Xie L, Ma J, Yang M, Wang B, Xu Y, Fan L, Mu G, Shi T, Chen W
Toxicology letters 2019 Oct 1;313:178-187
Toxicology letters 2019 Oct 1;313:178-187
Role of CCR2 in the Development of Streptozotocin-Treated Diabetic Cardiomyopathy.
Tan X, Hu L, Shu Z, Chen L, Li X, Du M, Sun D, Mao X, Deng S, Huang K, Zhang F
Diabetes 2019 Nov;68(11):2063-2073
Diabetes 2019 Nov;68(11):2063-2073
G9a and histone deacetylases are crucial for Snail2-mediated E-cadherin repression and metastasis in hepatocellular carcinoma.
Hu Y, Zheng Y, Dai M, Wang X, Wu J, Yu B, Zhang H, Cui Y, Kong W, Wu H, Yu X
Cancer science 2019 Nov;110(11):3442-3452
Cancer science 2019 Nov;110(11):3442-3452
ROCK2 Confers Acquired Gemcitabine Resistance in Pancreatic Cancer Cells by Upregulating Transcription Factor ZEB1.
Zhou Y, Zhou Y, Wang K, Li T, Zhang M, Yang Y, Wang R, Hu R
Cancers 2019 Nov 27;11(12)
Cancers 2019 Nov 27;11(12)
Olfactory ensheathing cells facilitate neurite sprouting and outgrowth by secreting high levels of hevin.
Ge L, Zhuo Y, Wu P, Liu Y, Qi L, Teng X, Duan D, Chen P, Lu M
Journal of chemical neuroanatomy 2019 Nov 26;104:101728
Journal of chemical neuroanatomy 2019 Nov 26;104:101728
HIC-5 in cancer-associated fibroblasts contributes to esophageal squamous cell carcinoma progression.
Du X, Xu Q, Pan D, Xu D, Niu B, Hong W, Zhang R, Li X, Chen S
Cell death & disease 2019 Nov 18;10(12):873
Cell death & disease 2019 Nov 18;10(12):873
SREBP1, targeted by miR-18a-5p, modulates epithelial-mesenchymal transition in breast cancer via forming a co-repressor complex with Snail and HDAC1/2.
Zhang N, Zhang H, Liu Y, Su P, Zhang J, Wang X, Sun M, Chen B, Zhao W, Wang L, Wang H, Moran MS, Haffty BG, Yang Q
Cell death and differentiation 2019 May;26(5):843-859
Cell death and differentiation 2019 May;26(5):843-859
MicroRNA-34a Promotes Renal Fibrosis by Downregulation of Klotho in Tubular Epithelial Cells.
Liu Y, Bi X, Xiong J, Han W, Xiao T, Xu X, Yang K, Liu C, Jiang W, He T, Yu Y, Li Y, Zhang J, Zhang B, Zhao J
Molecular therapy : the journal of the American Society of Gene Therapy 2019 May 8;27(5):1051-1065
Molecular therapy : the journal of the American Society of Gene Therapy 2019 May 8;27(5):1051-1065
Inhibition of lymphatic proliferation by the selective VEGFR-3 inhibitor SAR131675 ameliorates diabetic nephropathy in db/db mice.
Hwang SD, Song JH, Kim Y, Lim JH, Kim MY, Kim EN, Hong YA, Chung S, Choi BS, Kim YS, Park CW
Cell death & disease 2019 Mar 4;10(3):219
Cell death & disease 2019 Mar 4;10(3):219
Intervertebral disc regeneration with an adipose mesenchymal stem cell-derived tissue-engineered construct in a rat nucleotomy model.
Ishiguro H, Kaito T, Yarimitsu S, Hashimoto K, Okada R, Kushioka J, Chijimatsu R, Takenaka S, Makino T, Sakai Y, Moriguchi Y, Otsuru S, Hart DA, Fujie H, Nakamura N, Yoshikawa H
Acta biomaterialia 2019 Mar 15;87:118-129
Acta biomaterialia 2019 Mar 15;87:118-129
Ribes diacanthum Pall (RDP) ameliorates UUO-induced renal fibrosis via both canonical and non-canonical TGF-β signaling pathways in mice.
Gu L, Wang Y, Yang G, Tilyek A, Zhang C, Li S, Yu B, Chai C, Cao Z
Journal of ethnopharmacology 2019 Mar 1;231:302-310
Journal of ethnopharmacology 2019 Mar 1;231:302-310
Three kinds of corneal host cells contribute differently to corneal neovascularization.
Yu H, Sun L, Cui J, Li Y, Yan Y, Wei X, Wang C, Song F, Jiang W, Liu Y, Ge H, Qian H, Li X, Tang X, Liu P
EBioMedicine 2019 Jun;44:542-553
EBioMedicine 2019 Jun;44:542-553
EZH2-DNMT1-mediated epigenetic silencing of miR-142-3p promotes metastasis through targeting ZEB2 in nasopharyngeal carcinoma.
Li Y, He Q, Wen X, Hong X, Yang X, Tang X, Zhang P, Lei Y, Sun Y, Zhang J, Wang Y, Ma J, Liu N
Cell death and differentiation 2019 Jun;26(6):1089-1106
Cell death and differentiation 2019 Jun;26(6):1089-1106
RNF128 Promotes Invasion and Metastasis Via the EGFR/MAPK/MMP-2 Pathway in Esophageal Squamous Cell Carcinoma.
Gao J, Wang Y, Yang J, Zhang W, Meng K, Sun Y, Li Y, He QY
Cancers 2019 Jun 18;11(6)
Cancers 2019 Jun 18;11(6)
Role of PM(2.5) in the development and progression of COPD and its mechanisms.
Zhao J, Li M, Wang Z, Chen J, Zhao J, Xu Y, Wei X, Wang J, Xie J
Respiratory research 2019 Jun 13;20(1):120
Respiratory research 2019 Jun 13;20(1):120
Aspirin inhibits inflammation and scar formation in the injury tendon healing through regulating JNK/STAT-3 signalling pathway.
Wang Y, He G, Tang H, Shi Y, Kang X, Lyu J, Zhu M, Zhou M, Yang M, Mu M, Chen W, Zhou B, Zhang J, Tang K
Cell proliferation 2019 Jul;52(4):e12650
Cell proliferation 2019 Jul;52(4):e12650
LncRNA PFAR contributes to fibrogenesis in lung fibroblasts through competitively binding to miR-15a.
Sun J, Su W, Zhao X, Shan T, Jin T, Guo Y, Li C, Li R, Zhou Y, Shan H, Sun X, Liang H
Bioscience reports 2019 Jul 31;39(7)
Bioscience reports 2019 Jul 31;39(7)
Sphingosine kinase 1 promotes the metastasis of colorectal cancer by inducing the epithelial‑mesenchymal transition mediated by the FAK/AKT/MMPs axis.
Liu SQ, Xu CY, Wu WH, Fu ZH, He SW, Qin MB, Huang JA
International journal of oncology 2019 Jan;54(1):41-52
International journal of oncology 2019 Jan;54(1):41-52
Loss of TMEM126A promotes extracellular matrix remodeling, epithelial-to-mesenchymal transition, and breast cancer metastasis by regulating mitochondrial retrograde signaling.
Sun HF, Yang XL, Zhao Y, Tian Q, Chen MT, Zhao YY, Jin W
Cancer letters 2019 Jan;440-441:189-201
Cancer letters 2019 Jan;440-441:189-201
miR-196a-5p promotes metastasis of colorectal cancer via targeting IκBα.
Xin H, Wang C, Liu Z
BMC cancer 2019 Jan 8;19(1):30
BMC cancer 2019 Jan 8;19(1):30
Tinagl1 Suppresses Triple-Negative Breast Cancer Progression and Metastasis by Simultaneously Inhibiting Integrin/FAK and EGFR Signaling.
Shen M, Jiang YZ, Wei Y, Ell B, Sheng X, Esposito M, Kang J, Hang X, Zheng H, Rowicki M, Zhang L, Shih WJ, Celià-Terrassa T, Liu Y, Cristea I, Shao ZM, Kang Y
Cancer cell 2019 Jan 14;35(1):64-80.e7
Cancer cell 2019 Jan 14;35(1):64-80.e7
Protein kinase C inhibitor chelerythrine attenuates partial unilateral ureteral obstruction induced kidney injury in neonatal rats.
Shi B, Li S, Ju H, Liu X, Li D, Li Y
Life sciences 2019 Jan 1;216:85-91
Life sciences 2019 Jan 1;216:85-91
An improved cellular enucleation method with extracellular matrix and colchicine facilitates the study of nucleocytoplasmic interaction.
Chen Y, Xu LQ, Lin MJ, Zhang W, Zhang ZJ, Xu WC, Yang LJ, Wei CJ
European journal of cell biology 2019 Dec;98(5-8):151045
European journal of cell biology 2019 Dec;98(5-8):151045
Snail2 induced E-cadherin suppression and metastasis in lung carcinoma facilitated by G9a and HDACs.
Hu Y, Zheng Y, Dai M, Wu J, Yu B, Zhang H, Kong W, Wu H, Yu X
Cell adhesion & migration 2019 Dec;13(1):285-292
Cell adhesion & migration 2019 Dec;13(1):285-292
Injectable extracellular vesicle-released self-assembling peptide nanofiber hydrogel as an enhanced cell-free therapy for tissue regeneration.
Zhou Y, Liu S, Zhao M, Wang C, Li L, Yuan Y, Li L, Liao G, Bresette W, Zhang J, Chen Y, Cheng J, Lu Y, Liu J
Journal of controlled release : official journal of the Controlled Release Society 2019 Dec 28;316:93-104
Journal of controlled release : official journal of the Controlled Release Society 2019 Dec 28;316:93-104
Functional significance of U2AF1 S34F mutations in lung adenocarcinomas.
Esfahani MS, Lee LJ, Jeon YJ, Flynn RA, Stehr H, Hui AB, Ishisoko N, Kildebeck E, Newman AM, Bratman SV, Porteus MH, Chang HY, Alizadeh AA, Diehn M
Nature communications 2019 Dec 13;10(1):5712
Nature communications 2019 Dec 13;10(1):5712
MicroRNA-432 is downregulated in cervical cancer and directly targets FN1 to inhibit cell proliferation and invasion.
Wang S, Gao B, Yang H, Liu X, Wu X, Wang W
Oncology letters 2019 Aug;18(2):1475-1482
Oncology letters 2019 Aug;18(2):1475-1482
TGF-β-mediated upregulation of brachyury contributes to constitutively up-regulated type I collagen expression in skin fibroblasts: possible role in systemic sclerosis.
Teng L, Yao G, Gao R, Wang Y, Lin W, Jin Y, Wang Y, Chen H, Wang Z, Chen J
European journal of dermatology : EJD 2019 Aug 1;29(4):359-365
European journal of dermatology : EJD 2019 Aug 1;29(4):359-365
Astaxanthin ameliorates renal interstitial fibrosis and peritubular capillary rarefaction in unilateral ureteral obstruction.
Zhao J, Meng M, Zhang J, Li L, Zhu X, Zhang L, Wang C, Gao M
Molecular medicine reports 2019 Apr;19(4):3168-3178
Molecular medicine reports 2019 Apr;19(4):3168-3178
Effects of SIRT1 silencing on viability, invasion and metastasis of human glioma cell lines.
Li Y, Chen X, Cui Y, Wei Q, Chen S, Wang X
Oncology letters 2019 Apr;17(4):3701-3708
Oncology letters 2019 Apr;17(4):3701-3708
Citrus alkaline extracts prevent fibroblast senescence to ameliorate pulmonary fibrosis via activation of COX-2.
Feng F, Wang Z, Li R, Wu Q, Gu C, Xu Y, Peng W, Han D, Zhou X, Wu J, He H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Apr;112:108669
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Apr;112:108669
LncRNA PFL contributes to cardiac fibrosis by acting as a competing endogenous RNA of let-7d.
Liang H, Pan Z, Zhao X, Liu L, Sun J, Su X, Xu C, Zhou Y, Zhao D, Xu B, Li X, Yang B, Lu Y, Shan H
Theranostics 2018;8(4):1180-1194
Theranostics 2018;8(4):1180-1194
Inhibition of SIRT2 Alleviates Fibroblast Activation and Renal Tubulointerstitial Fibrosis via MDM2.
He FF, You RY, Ye C, Lei CT, Tang H, Su H, Zhang C
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;46(2):451-460
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;46(2):451-460
Kindlin-2 regulates hepatic stellate cells activation and liver fibrogenesis.
Yu J, Hu Y, Gao Y, Li Q, Zeng Z, Li Y, Chen H
Cell death discovery 2018;4:34
Cell death discovery 2018;4:34
Cyclin G2 Suppresses Glomerulosclerosis by Regulating Canonical Wnt Signalling.
Zhao C, Gao J, Li S, Liu Q, Hou X, Liu S, Xing X, Sun M, Wang S, Luo Y
BioMed research international 2018;2018:6938482
BioMed research international 2018;2018:6938482
Kidney-targeted drug delivery via rhein-loaded polyethyleneglycol-co-polycaprolactone-co-polyethylenimine nanoparticles for diabetic nephropathy therapy.
Chen D, Han S, Zhu Y, Hu F, Wei Y, Wang G
International journal of nanomedicine 2018;13:3507-3527
International journal of nanomedicine 2018;13:3507-3527
Wenyang Huazhuo Tongluo formula inhibits fibrosis via suppressing Wnt/β-catenin signaling pathway in a Bleomycin-induced systemic sclerosis mouse model.
Wang Q, Zang W, Han L, Yang L, Ye S, Ouyang J, Zhang C, Bi Y, Zhang C, Bian H
Chinese medicine 2018;13:17
Chinese medicine 2018;13:17
Renal-protective effect of thalidomide in streptozotocin-induced diabetic rats through anti-inflammatory pathway.
Zhang H, Yang Y, Wang Y, Wang B, Li R
Drug design, development and therapy 2018;12:89-98
Drug design, development and therapy 2018;12:89-98
LncRNA UCA1 sponges miR-204-5p to promote migration, invasion and epithelial-mesenchymal transition of glioma cells via upregulation of ZEB1.
Liang C, Yang Y, Guan J, Lv T, Qu S, Fu Q, Zhao H
Pathology, research and practice 2018 Sep;214(9):1474-1481
Pathology, research and practice 2018 Sep;214(9):1474-1481
A novel bioscaffold with naturally-occurring extracellular matrix promotes hepatocyte survival and vessel patency in mouse models of heterologous transplantation.
Yang W, Chen Q, Xia R, Zhang Y, Shuai L, Lai J, You X, Jiang Y, Bie P, Zhang L, Zhang H, Bai L
Biomaterials 2018 Sep;177:52-66
Biomaterials 2018 Sep;177:52-66
lncRNA PFAR Promotes Lung Fibroblast Activation and Fibrosis by Targeting miR-138 to Regulate the YAP1-Twist Axis.
Zhao X, Sun J, Chen Y, Su W, Shan H, Li Y, Wang Y, Zheng N, Shan H, Liang H
Molecular therapy : the journal of the American Society of Gene Therapy 2018 Sep 5;26(9):2206-2217
Molecular therapy : the journal of the American Society of Gene Therapy 2018 Sep 5;26(9):2206-2217
S3I-201 ameliorates tubulointerstitial lesion of the kidneys in MRL/lpr mice.
Du Y, Zhang W, Liu S, Feng X, Gao F, Liu Q
Biochemical and biophysical research communications 2018 Sep 3;503(1):177-180
Biochemical and biophysical research communications 2018 Sep 3;503(1):177-180
NMDA receptor activation inhibits the antifibrotic effect of BM-MSCs on bleomycin-induced pulmonary fibrosis.
Li X, Li C, Tang Y, Huang Y, Cheng Q, Huang X, Zhao F, Hao C, Feng D, Xu J, Han J, Tang S, Liu W, Yue S, Luo Z
American journal of physiology. Lung cellular and molecular physiology 2018 Sep 1;315(3):L404-L421
American journal of physiology. Lung cellular and molecular physiology 2018 Sep 1;315(3):L404-L421
lncRNA PFAL promotes lung fibrosis through CTGF by competitively binding miR-18a.
Li X, Yu T, Shan H, Jiang H, Sun J, Zhao X, Su W, Yang L, Shan H, Liang H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Oct;32(10):5285-5297
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Oct;32(10):5285-5297
Inhibition of lncRNA PFRL prevents pulmonary fibrosis by disrupting the miR-26a/smad2 loop.
Jiang H, Chen Y, Yu T, Zhao X, Shan H, Sun J, Zhang L, Li X, Shan H, Liang H
American journal of physiology. Lung cellular and molecular physiology 2018 Oct 1;315(4):L563-L575
American journal of physiology. Lung cellular and molecular physiology 2018 Oct 1;315(4):L563-L575
The pro-metastasis effect of circANKS1B in breast cancer.
Zeng K, He B, Yang BB, Xu T, Chen X, Xu M, Liu X, Sun H, Pan Y, Wang S
Molecular cancer 2018 Nov 19;17(1):160
Molecular cancer 2018 Nov 19;17(1):160
Effects of Resveratrol on the Renin-Angiotensin System in the Aging Kidney.
Jang IA, Kim EN, Lim JH, Kim MY, Ban TH, Yoon HE, Park CW, Chang YS, Choi BS
Nutrients 2018 Nov 12;10(11)
Nutrients 2018 Nov 12;10(11)
Towards an in vitro fibrogenesis model of human vocal fold scarring.
Graupp M, Rinner B, Frisch MT, Weiss G, Fuchs J, Sundl M, El-Heliebi A, Moser G, Kamolz LP, Karbiener M, Gugatschka M
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 2018 May;275(5):1211-1218
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 2018 May;275(5):1211-1218
Methanol fixed fibroblasts serve as feeder cells to maintain stem cells in the pluripotent state in vitro.
Ren Y, Ma Z, Yu T, Ling M, Wang H
Scientific reports 2018 May 17;8(1):7780
Scientific reports 2018 May 17;8(1):7780
Rotenone ameliorates chronic renal injury caused by acute ischemia/reperfusion.
Zhang W, Sha Y, Wei K, Wu C, Ding D, Yang Y, Zhu C, Zhang Y, Ding G, Zhang A, Jia Z, Huang S
Oncotarget 2018 May 11;9(36):24199-24208
Oncotarget 2018 May 11;9(36):24199-24208
Fibronectin Facilitates Enterovirus 71 Infection by Mediating Viral Entry.
He QQ, Ren S, Xia ZC, Cheng ZK, Peng NF, Zhu Y
Journal of virology 2018 May 1;92(9)
Journal of virology 2018 May 1;92(9)
LincRNA 1700020I14Rik alleviates cell proliferation and fibrosis in diabetic nephropathy via miR-34a-5p/Sirt1/HIF-1α signaling.
Li A, Peng R, Sun Y, Liu H, Peng H, Zhang Z
Cell death & disease 2018 May 1;9(5):461
Cell death & disease 2018 May 1;9(5):461
The protective effect of resveratrol on vascular aging by modulation of the renin-angiotensin system.
Kim EN, Kim MY, Lim JH, Kim Y, Shin SJ, Park CW, Kim YS, Chang YS, Yoon HE, Choi BS
Atherosclerosis 2018 Mar;270:123-131
Atherosclerosis 2018 Mar;270:123-131
RhoA/Rho-kinase triggers epithelial-mesenchymal transition in mesothelial cells and contributes to the pathogenesis of dialysis-related peritoneal fibrosis.
Wang Q, Yang X, Xu Y, Shen Z, Cheng H, Cheng F, Liu X, Wang R
Oncotarget 2018 Mar 6;9(18):14397-14412
Oncotarget 2018 Mar 6;9(18):14397-14412
Autophagy inhibition attenuates the induction of anti-inflammatory effect of catalpol in liver fibrosis.
Liu Z, Zhu P, Zhang L, Xiong B, Tao J, Guan W, Li C, Chen C, Gu J, Duanmu J, Zhang W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jul;103:1262-1271
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jul;103:1262-1271
Administration of cytokine-induced myeloid-derived suppressor cells ameliorates renal fibrosis in diabetic mice.
Hsieh CC, Lin CL, He JT, Chiang M, Wang Y, Tsai YC, Hung CH, Chang PJ
Stem cell research & therapy 2018 Jul 4;9(1):183
Stem cell research & therapy 2018 Jul 4;9(1):183
Stachydrine ameliorates carbon tetrachloride-induced hepatic fibrosis by inhibiting inflammation, oxidative stress and regulating MMPs/TIMPs system in rats.
Zhang J, Yang A, Wu Y, Guan W, Xiong B, Peng X, Wei X, Chen C, Liu Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jan;97:1586-1594
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jan;97:1586-1594
β-Arrestin-1 deficiency ameliorates renal interstitial fibrosis by blocking Wnt1/β-catenin signaling in mice.
Xu H, Li Q, Liu J, Zhu J, Li L, Wang Z, Zhang Y, Sun Y, Sun J, Wang R, Yi F
Journal of molecular medicine (Berlin, Germany) 2018 Jan;96(1):97-109
Journal of molecular medicine (Berlin, Germany) 2018 Jan;96(1):97-109
Aucubin Protects against TGFβ1-Induced Cardiac Fibroblasts Activation by Mediating the AMPKα/mTOR Signaling Pathway.
Xiao Y, Chang W, Wu QQ, Jiang XH, Duan MX, Jin YG, Tang QZ
Planta medica 2018 Jan;84(2):91-99
Planta medica 2018 Jan;84(2):91-99
Regulation of pancreatic stellate cell activation by Notch3.
Song H, Zhang Y
BMC cancer 2018 Jan 5;18(1):36
BMC cancer 2018 Jan 5;18(1):36
PLZF inhibits proliferation and metastasis of gallbladder cancer by regulating IFIT2.
Shen H, Zhan M, Zhang Y, Huang S, Xu S, Huang X, He M, Yao Y, Man M, Wang J
Cell death & disease 2018 Jan 22;9(2):71
Cell death & disease 2018 Jan 22;9(2):71
SIRT3 prevents angiotensin II-induced renal tubular epithelial-mesenchymal transition by ameliorating oxidative stress and mitochondrial dysfunction.
He P, Li Z, Yue Z, Gao H, Feng G, Wang P, Huang Y, Luo W, Hong H, Liang L, Chen S, Liu P
Molecular and cellular endocrinology 2018 Jan 15;460:1-13
Molecular and cellular endocrinology 2018 Jan 15;460:1-13
Salvianolic acid B inhibits myofibroblast transdifferentiation in experimental pulmonary fibrosis via the up-regulation of Nrf2.
Liu M, Xu H, Zhang L, Zhang C, Yang L, Ma E, Liu L, Li Y
Biochemical and biophysical research communications 2018 Jan 1;495(1):325-331
Biochemical and biophysical research communications 2018 Jan 1;495(1):325-331
Nicotine Induces Progressive Properties of Lung Adenocarcinoma A549 Cells by Inhibiting Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Expression and Plasma Membrane Localization.
Li H, Ma N, Wang J, Wang Y, Yuan C, Wu J, Luo M, Yang J, Chen J, Shi J, Liu X
Technology in cancer research & treatment 2018 Jan 1;17:1533033818809984
Technology in cancer research & treatment 2018 Jan 1;17:1533033818809984
Autophagy promotes fibrosis and apoptosis in the peritoneum during long-term peritoneal dialysis.
Wu J, Xing C, Zhang L, Mao H, Chen X, Liang M, Wang F, Ren H, Cui H, Jiang A, Wang Z, Zou M, Ji Y
Journal of cellular and molecular medicine 2018 Feb;22(2):1190-1201
Journal of cellular and molecular medicine 2018 Feb;22(2):1190-1201
Ursolic Acid Attenuates High Glucose-Mediated Mesangial Cell Injury by Inhibiting the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR) Signaling Pathway.
Wang EM, Fan QL, Yue Y, Xu L
Medical science monitor : international medical journal of experimental and clinical research 2018 Feb 11;24:846-854
Medical science monitor : international medical journal of experimental and clinical research 2018 Feb 11;24:846-854
A cell culture condition that induces the mesenchymal-epithelial transition of dedifferentiated porcine retinal pigment epithelial cells.
Tian H, Xu JY, Tian Y, Cao Y, Lian C, Ou Q, Wu B, Jin C, Gao F, Wang J, Zhang J, Zhang J, Li W, Lu L, Xu GT
Experimental eye research 2018 Dec;177:160-172
Experimental eye research 2018 Dec;177:160-172
CAPE-pNO(2) attenuates diabetic cardiomyopathy through the NOX4/NF-κB pathway in STZ-induced diabetic mice.
Fan L, Xiao Q, Zhang L, Wang X, Huang Q, Li S, Zhao X, Li Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Dec;108:1640-1650
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Dec;108:1640-1650
Binding of a glaucoma-associated myocilin variant to the αB-crystallin chaperone impedes protein clearance in trabecular meshwork cells.
Lynch JM, Li B, Katoli P, Xiang C, Leehy B, Rangaswamy N, Saenz-Vash V, Wang YK, Lei H, Nicholson TB, Meredith E, Rice DS, Prasanna G, Chen A
The Journal of biological chemistry 2018 Dec 28;293(52):20137-20156
The Journal of biological chemistry 2018 Dec 28;293(52):20137-20156
Tamoxifen attenuates dialysate-induced peritoneal fibrosis by inhibiting GSK-3β/β-catenin axis activation.
Yan P, Tang H, Chen X, Ji S, Jin W, Zhang J, Shen J, Deng H, Zhao X, Shen Q, Huang H
Bioscience reports 2018 Dec 21;38(6)
Bioscience reports 2018 Dec 21;38(6)
Epigenetic suppression of E-cadherin expression by Snail2 during the metastasis of colorectal cancer.
Hu Y, Dai M, Zheng Y, Wu J, Yu B, Zhang H, Kong W, Wu H, Yu X
Clinical epigenetics 2018 Dec 12;10(1):154
Clinical epigenetics 2018 Dec 12;10(1):154
RGC-32 regulates reactive astrocytosis and extracellular matrix deposition in experimental autoimmune encephalomyelitis.
Tatomir A, Tegla CA, Martin A, Boodhoo D, Nguyen V, Sugarman AJ, Mekala A, Anselmo F, Talpos-Caia A, Cudrici C, Badea TC, Rus V, Rus H
Immunologic research 2018 Aug;66(4):445-461
Immunologic research 2018 Aug;66(4):445-461
Upregulation of allograft inflammatory factor‑1 expression and secretion by macrophages stimulated with aldosterone promotes renal fibroblasts to a profibrotic phenotype.
Li Y, Wang X, Zhang L, Yuan X, Hao J, Ni J, Hao L
International journal of molecular medicine 2018 Aug;42(2):861-872
International journal of molecular medicine 2018 Aug;42(2):861-872
SNAI1, an endothelial-mesenchymal transition transcription factor, promotes the early phase of ocular neovascularization.
Sun JX, Chang TF, Li MH, Sun LJ, Yan XC, Yang ZY, Liu Y, Xu WQ, Lv Y, Su JB, Liang L, Han H, Dou GR, Wang YS
Angiogenesis 2018 Aug;21(3):635-652
Angiogenesis 2018 Aug;21(3):635-652
Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem.
Han X, Li Y, Xu Y, Zhao X, Zhang Y, Yang X, Wang Y, Zhao R, Anderson GJ, Zhao Y, Nie G
Nature communications 2018 Aug 23;9(1):3390
Nature communications 2018 Aug 23;9(1):3390
LncRNA PTAR promotes EMT and invasion-metastasis in serous ovarian cancer by competitively binding miR-101-3p to regulate ZEB1 expression.
Liang H, Yu T, Han Y, Jiang H, Wang C, You T, Zhao X, Shan H, Yang R, Yang L, Shan H, Gu Y
Molecular cancer 2018 Aug 11;17(1):119
Molecular cancer 2018 Aug 11;17(1):119
Melatonin Protects against Lung Fibrosis by Regulating the Hippo/YAP Pathway.
Zhao X, Sun J, Su W, Shan H, Zhang B, Wang Y, Shabanova A, Shan H, Liang H
International journal of molecular sciences 2018 Apr 9;19(4)
International journal of molecular sciences 2018 Apr 9;19(4)
Novel decellularized liver matrix-alginate hybrid gel beads for the 3D culture of hepatocellular carcinoma cells.
Sun D, Liu Y, Wang H, Deng F, Zhang Y, Zhao S, Ma X, Wu H, Sun G
International journal of biological macromolecules 2018 Apr 1;109:1154-1163
International journal of biological macromolecules 2018 Apr 1;109:1154-1163
Saxagliptin Attenuates Albuminuria by Inhibiting Podocyte Epithelial- to-Mesenchymal Transition via SDF-1α in Diabetic Nephropathy.
Chang YP, Sun B, Han Z, Han F, Hu SL, Li XY, Xue M, Yang Y, Chen L, Li CJ, Chen LM
Frontiers in pharmacology 2017;8:780
Frontiers in pharmacology 2017;8:780
The TGF-β System As a Potential Pathogenic Player in Disease Modulation of Amyotrophic Lateral Sclerosis.
Peters S, Zitzelsperger E, Kuespert S, Iberl S, Heydn R, Johannesen S, Petri S, Aigner L, Thal DR, Hermann A, Weishaupt JH, Bruun TH, Bogdahn U
Frontiers in neurology 2017;8:669
Frontiers in neurology 2017;8:669
Dioscin, a potent ITGA5 inhibitor, reduces the synthesis of collagen against liver fibrosis: Insights from SILAC-based proteomics analysis.
Xu L, Yin L, Tao X, Qi Y, Han X, Xu Y, Song S, Li L, Sun P, Peng J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Sep;107(Pt A):318-328
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2017 Sep;107(Pt A):318-328
Pancreatic cancer-derived exosomes promote tumor metastasis and liver pre-metastatic niche formation.
Yu Z, Zhao S, Ren L, Wang L, Chen Z, Hoffman RM, Zhou J
Oncotarget 2017 Sep 8;8(38):63461-63483
Oncotarget 2017 Sep 8;8(38):63461-63483
MDM2 Contributes to High Glucose-Induced Glomerular Mesangial Cell Proliferation and Extracellular Matrix Accumulation via Notch1.
Lei CT, Tang H, Ye C, You CQ, Zhang J, Zhang CY, Xiong W, Su H, Zhang C
Scientific reports 2017 Sep 4;7(1):10393
Scientific reports 2017 Sep 4;7(1):10393
FZD7 is a novel prognostic marker and promotes tumor metastasis via WNT and EMT signaling pathways in esophageal squamous cell carcinoma.
Cao TT, Xiang D, Liu BL, Huang TX, Tan BB, Zeng CM, Wang ZY, Ming XY, Zhang LY, Jin G, Li F, Wu JL, Guan XY, Lu D, Fu L
Oncotarget 2017 Sep 12;8(39):65957-65968
Oncotarget 2017 Sep 12;8(39):65957-65968
Calreticulin promotes EGF-induced EMT in pancreatic cancer cells via Integrin/EGFR-ERK/MAPK signaling pathway.
Sheng W, Chen C, Dong M, Wang G, Zhou J, Song H, Li Y, Zhang J, Ding S
Cell death & disease 2017 Oct 26;8(10):e3147
Cell death & disease 2017 Oct 26;8(10):e3147
ANGPTL1 Interacts with Integrin α1β1 to Suppress HCC Angiogenesis and Metastasis by Inhibiting JAK2/STAT3 Signaling.
Yan Q, Jiang L, Liu M, Yu D, Zhang Y, Li Y, Fang S, Li Y, Zhu YH, Yuan YF, Guan XY
Cancer research 2017 Nov 1;77(21):5831-5845
Cancer research 2017 Nov 1;77(21):5831-5845
Losartan Attenuates Scar Formation in Filtering Bleb After Trabeculectomy.
Shi H, Wang H, Fu S, Xu K, Zhang X, Xiao Y, Ye W
Investigative ophthalmology & visual science 2017 Mar 1;58(3):1478-1486
Investigative ophthalmology & visual science 2017 Mar 1;58(3):1478-1486
Evodiamine attenuates TGF-β1-induced fibroblast activation and endothelial to mesenchymal transition.
Wu QQ, Xiao Y, Jiang XH, Yuan Y, Yang Z, Chang W, Bian ZY, Tang QZ
Molecular and cellular biochemistry 2017 Jun;430(1-2):81-90
Molecular and cellular biochemistry 2017 Jun;430(1-2):81-90
miR-206 inhibits FN1 expression and proliferation and promotes apoptosis of rat type II alveolar epithelial cells.
Duan J, Zhang X, Zhang S, Hua S, Feng Z
Experimental and therapeutic medicine 2017 Jun;13(6):3203-3208
Experimental and therapeutic medicine 2017 Jun;13(6):3203-3208
NUBPL, a novel metastasis-related gene, promotes colorectal carcinoma cell motility by inducing epithelial-mesenchymal transition.
Wang Y, Wu N, Sun D, Sun H, Tong D, Liu D, Pang B, Li S, Wei J, Dai J, Liu Y, Bai J, Geng J, Fu S, Jin Y
Cancer science 2017 Jun;108(6):1169-1176
Cancer science 2017 Jun;108(6):1169-1176
TGFβ-incurred epigenetic aberrations of miRNA and DNA methyltransferase suppress Klotho and potentiate renal fibrosis.
Yin S, Zhang Q, Yang J, Lin W, Li Y, Chen F, Cao W
Biochimica et biophysica acta. Molecular cell research 2017 Jul;1864(7):1207-1216
Biochimica et biophysica acta. Molecular cell research 2017 Jul;1864(7):1207-1216
Glucose variability aggravates cardiac fibrosis by altering AKT signalling path.
Ying C, Liu T, Ling H, Cheng M, Zhou X, Wang S, Mao Y, Chen L, Zhang R, Li W
Diabetes & vascular disease research 2017 Jul;14(4):327-335
Diabetes & vascular disease research 2017 Jul;14(4):327-335
Autophagy plays a role in FSTL1-induced epithelial mesenchymal transition and airway remodeling in asthma.
Liu T, Liu Y, Miller M, Cao L, Zhao J, Wu J, Wang J, Liu L, Li S, Zou M, Xu J, Broide DH, Dong L
American journal of physiology. Lung cellular and molecular physiology 2017 Jul 1;313(1):L27-L40
American journal of physiology. Lung cellular and molecular physiology 2017 Jul 1;313(1):L27-L40
Rhein reverses Klotho repression via promoter demethylation and protects against kidney and bone injuries in mice with chronic kidney disease.
Zhang Q, Liu L, Lin W, Yin S, Duan A, Liu Z, Cao W
Kidney international 2017 Jan;91(1):144-156
Kidney international 2017 Jan;91(1):144-156
Phosphoinositide 3-kinase/protein kinase B/periostin mediated platelet-derived growth factor-induced cell proliferation and extracellular matrix production in lupus nephritis.
Zhao X, Hao J, Duan H, Rong Z, Li F
Experimental biology and medicine (Maywood, N.J.) 2017 Jan;242(2):160-168
Experimental biology and medicine (Maywood, N.J.) 2017 Jan;242(2):160-168
5-Aza-2'-deoxycytidine induces human Tenon's capsule fibroblasts differentiation and fibrosis by up-regulating TGF-β type I receptor.
Fu S, Sun L, Zhang X, Shi H, Xu K, Xiao Y, Ye W
Experimental eye research 2017 Dec;165:47-58
Experimental eye research 2017 Dec;165:47-58
MicroRNA-139 targets fibronectin 1 to inhibit papillary thyroid carcinoma progression.
Ye Y, Zhuang J, Wang G, He S, Ni J, Xia W
Oncology letters 2017 Dec;14(6):7799-7806
Oncology letters 2017 Dec;14(6):7799-7806
Low molecular weight fucoidan and its fractions inhibit renal epithelial mesenchymal transition induced by TGF-β1 or FGF-2.
Li X, Li X, Zhang Q, Zhao T
International journal of biological macromolecules 2017 Dec;105(Pt 2):1482-1490
International journal of biological macromolecules 2017 Dec;105(Pt 2):1482-1490
CAPE-pNO(2) ameliorated diabetic nephropathy through regulating the Akt/NF-κB/ iNOS pathway in STZ-induced diabetic mice.
Wang X, Li D, Fan L, Xiao Q, Zuo H, Li Z
Oncotarget 2017 Dec 29;8(70):114506-114525
Oncotarget 2017 Dec 29;8(70):114506-114525
Triptolide Restores Autophagy to Alleviate Diabetic Renal Fibrosis through the miR-141-3p/PTEN/Akt/mTOR Pathway.
Li XY, Wang SS, Han Z, Han F, Chang YP, Yang Y, Xue M, Sun B, Chen LM
Molecular therapy. Nucleic acids 2017 Dec 15;9:48-56
Molecular therapy. Nucleic acids 2017 Dec 15;9:48-56
Sesamin prevents apoptosis and inflammation after experimental myocardial infarction by JNK and NF-κB pathways.
Fan D, Yang Z, Yuan Y, Wu QQ, Xu M, Jin YG, Tang QZ
Food & function 2017 Aug 1;8(8):2875-2885
Food & function 2017 Aug 1;8(8):2875-2885
MDM2 mediates fibroblast activation and renal tubulointerstitial fibrosis via a p53-independent pathway.
Ye C, Tang H, Zhao Z, Lei CT, You CQ, Zhang J, Gao P, He FF, Chen S, Wang YM, Zhang C, Su H
American journal of physiology. Renal physiology 2017 Apr 1;312(4):F760-F768
American journal of physiology. Renal physiology 2017 Apr 1;312(4):F760-F768
Naringenin Ameliorated Kidney Injury through Let-7a/TGFBR1 Signaling in Diabetic Nephropathy.
Yan N, Wen L, Peng R, Li H, Liu H, Peng H, Sun Y, Wu T, Chen L, Duan Q, Sun Y, Zhou Q, Wei L, Zhang Z
Journal of diabetes research 2016;2016:8738760
Journal of diabetes research 2016;2016:8738760
Age-Associated Changes in the Vascular Renin-Angiotensin System in Mice.
Yoon HE, Kim EN, Kim MY, Lim JH, Jang IA, Ban TH, Shin SJ, Park CW, Chang YS, Choi BS
Oxidative medicine and cellular longevity 2016;2016:6731093
Oxidative medicine and cellular longevity 2016;2016:6731093
Quantitative Proteomic Profiling the Molecular Signatures of Annexin A5 in Lung Squamous Carcinoma Cells.
Sun B, Bai Y, Zhang L, Gong L, Qi X, Li H, Wang F, Chi X, Jiang Y, Shao S
PloS one 2016;11(9):e0163622
PloS one 2016;11(9):e0163622
Hepatitis B Virus Stimulated Fibronectin Facilitates Viral Maintenance and Replication through Two Distinct Mechanisms.
Ren S, Wang J, Chen TL, Li HY, Wan YS, Peng NF, Gui XE, Zhu Y
PloS one 2016;11(3):e0152721
PloS one 2016;11(3):e0152721
Emodin ameliorates bleomycin-induced pulmonary fibrosis in rats by suppressing epithelial-mesenchymal transition and fibroblast activation.
Guan R, Wang X, Zhao X, Song N, Zhu J, Wang J, Wang J, Xia C, Chen Y, Zhu D, Shen L
Scientific reports 2016 Oct 24;6:35696
Scientific reports 2016 Oct 24;6:35696
MAD2B promotes tubular epithelial-to-mesenchymal transition and renal tubulointerstitial fibrosis via Skp2.
Tang H, Fan D, Lei CT, Ye C, Gao P, Chen S, Meng XF, Su H, Zhang C
Journal of molecular medicine (Berlin, Germany) 2016 Nov;94(11):1297-1307
Journal of molecular medicine (Berlin, Germany) 2016 Nov;94(11):1297-1307
Emodin alleviates bleomycin-induced pulmonary fibrosis in rats.
Guan R, Zhao X, Wang X, Song N, Guo Y, Yan X, Jiang L, Cheng W, Shen L
Toxicology letters 2016 Nov 16;262:161-172
Toxicology letters 2016 Nov 16;262:161-172
Sinomenine activation of Nrf2 signaling prevents hyperactive inflammation and kidney injury in a mouse model of obstructive nephropathy.
Qin T, Du R, Huang F, Yin S, Yang J, Qin S, Cao W
Free radical biology & medicine 2016 Mar;92:90-99
Free radical biology & medicine 2016 Mar;92:90-99
miR-26a suppresses EMT by disrupting the Lin28B/let-7d axis: potential cross-talks among miRNAs in IPF.
Liang H, Liu S, Chen Y, Bai X, Liu L, Dong Y, Hu M, Su X, Chen Y, Huangfu L, Li X, Gu Y, Shan H
Journal of molecular medicine (Berlin, Germany) 2016 Jun;94(6):655-65
Journal of molecular medicine (Berlin, Germany) 2016 Jun;94(6):655-65
Silence of fibronectin 1 increases cisplatin sensitivity of non-small cell lung cancer cell line.
Gao W, Liu Y, Qin R, Liu D, Feng Q
Biochemical and biophysical research communications 2016 Jul 15;476(1):35-41
Biochemical and biophysical research communications 2016 Jul 15;476(1):35-41
Glucocorticoid exposure in early placentation induces preeclampsia in rats via interfering trophoblast development.
Zhang D, Liu H, Zeng J, Miao X, Huang W, Chen H, Huang Y, Li Y, Ye D
General and comparative endocrinology 2016 Jan 1;225:61-70
General and comparative endocrinology 2016 Jan 1;225:61-70
Sinomenine attenuates renal fibrosis through Nrf2-mediated inhibition of oxidative stress and TGFβ signaling.
Qin T, Yin S, Yang J, Zhang Q, Liu Y, Huang F, Cao W
Toxicology and applied pharmacology 2016 Aug 1;304:1-8
Toxicology and applied pharmacology 2016 Aug 1;304:1-8
The anti-fibrotic effects of microRNA-153 by targeting TGFBR-2 in pulmonary fibrosis.
Liang C, Li X, Zhang L, Cui D, Quan X, Yang W
Experimental and molecular pathology 2015 Oct;99(2):279-85
Experimental and molecular pathology 2015 Oct;99(2):279-85
Pediatric Origins of Nephrolithiasis-Associated Atherosclerosis.
Kusumi K, Smith S, Barr-Beare E, Saxena V, Schober MS, Moore-Clingenpeel M, Schwaderer AL
The Journal of pediatrics 2015 Nov;167(5):1074-80.e2
The Journal of pediatrics 2015 Nov;167(5):1074-80.e2
MiR-25 promotes hepatocellular carcinoma cell growth, migration and invasion by inhibiting RhoGDI1.
Wang C, Wang X, Su Z, Fei H, Liu X, Pan Q
Oncotarget 2015 Nov 3;6(34):36231-44
Oncotarget 2015 Nov 3;6(34):36231-44
Protective Effect of the Total Saponins from Rosa laevigata Michx Fruit against Carbon Tetrachloride-Induced Liver Fibrosis in Rats.
Dong D, Yin L, Qi Y, Xu L, Peng J
Nutrients 2015 Jun 15;7(6):4829-50
Nutrients 2015 Jun 15;7(6):4829-50
IL-33 promotes airway remodeling and is a marker of asthma disease severity.
Guo Z, Wu J, Zhao J, Liu F, Chen Y, Bi L, Liu S, Dong L
The Journal of asthma : official journal of the Association for the Care of Asthma 2014 Oct;51(8):863-9
The Journal of asthma : official journal of the Association for the Care of Asthma 2014 Oct;51(8):863-9
Benzalkonium chloride induces subconjunctival fibrosis through the COX-2-modulated activation of a TGF-β1/Smad3 signaling pathway.
Huang C, Wang H, Pan J, Zhou D, Chen W, Li W, Chen Y, Liu Z
Investigative ophthalmology & visual science 2014 Nov 18;55(12):8111-22
Investigative ophthalmology & visual science 2014 Nov 18;55(12):8111-22
miR-203 inhibits tumor cell migration and invasion via caveolin-1 in pancreatic cancer cells.
Miao L, Xiong X, Lin Y, Cheng Y, Lu J, Zhang J, Cheng N
Oncology letters 2014 Mar;7(3):658-662
Oncology letters 2014 Mar;7(3):658-662
miR-483-5p promotes invasion and metastasis of lung adenocarcinoma by targeting RhoGDI1 and ALCAM.
Song Q, Xu Y, Yang C, Chen Z, Jia C, Chen J, Zhang Y, Lai P, Fan X, Zhou X, Lin J, Li M, Ma W, Luo S, Bai X
Cancer research 2014 Jun 1;74(11):3031-42
Cancer research 2014 Jun 1;74(11):3031-42
Reduction of microRNA-206 contributes to the development of bronchopulmonary dysplasia through up-regulation of fibronectin 1.
Zhang X, Xu J, Wang J, Gortner L, Zhang S, Wei X, Song J, Zhang Y, Li Q, Feng Z
PloS one 2013;8(9):e74750
PloS one 2013;8(9):e74750
Brucine, an alkaloid from seeds of Strychnos nux-vomica Linn., represses hepatocellular carcinoma cell migration and metastasis: the role of hypoxia inducible factor 1 pathway.
Shu G, Mi X, Cai J, Zhang X, Yin W, Yang X, Li Y, Chen L, Deng X
Toxicology letters 2013 Oct 24;222(2):91-101
Toxicology letters 2013 Oct 24;222(2):91-101
Global profiling of proteolytically modified proteins in human metastatic hepatocellular carcinoma cell lines reveals CAPN2 centered network.
Shen C, Yu Y, Li H, Yan G, Liu M, Shen H, Yang P
Proteomics 2012 Jun;12(12):1917-27
Proteomics 2012 Jun;12(12):1917-27
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- NIH/3T3 cells were subjected to SDS PAGE followed by western blot with 15613-1-AP(FN1 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human colon cancer using 15613-1-AP(FN1 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Fibronectin antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Fibronectin. This antibody recognizes human,mouse,rat antigen. The Fibronectin antibody has been validated for the following applications: ELISA, WB, IHC analysis.
