RA0256

antibody from Oursmab

Targeting: FN1 CIG, FINC, GFND2, LETS, MSF

ELISA (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Functional assay (Recommended by provider)

Antibody Data

Product number

RA0256

Provider

Oursmab

Product name

Onfekafusp (Biosimilar Reference Antibody) (FN extracellular domain B)

Antibody type

Monoclonal

Description

Onfekafusp alfa (also known as L19TNF) is a homotrimeric fusion protein consisting of the L19 single-chain antibody fragment (scFv) fused to human tumor necrosis factor (TNF). The L19 scFv specifically targets the extra domain B (ED-B) of fibronectin, a protein that is abundantly and selectively expressed in the tumor vasculature and stroma of many solid tumors but is virtually absent in normal adult tissues. This targeting directs the potent cytokine TNF to the tumor microenvironment. Once localized, TNF exerts its pro-inflammatory and cytotoxic effects on tumor vessels and stromal cells, leading to vascular disruption, immune cell recruitment, and tumor necrosis. It is being developed as a targeted immunocytokine for the treatment of advanced solid tumors.

Reactivity

Human

Vial size

100 ¦Ìg,1 mg,5 mg,10 mg,25 mg,50 mg,100 mg

Concentration

Bottled at the concentration indicated on the vial.

Storage

Store at -20¡ãC or -80¡ãC. Avoid repeated freeze.