12609-1-AP

antibody from Proteintech Group

Targeting: WT1 AWT1, GUD, NPHS4, WAGR, WIT-2

Provider product page for 12609-1-AP

Western blot

ELISA

Immunocytochemistry

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Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [37]
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Validations
Western blot [1]

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Product number: 12609-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#12609-1-AP, RRID:AB_2216225
Product name: WT1 antibody
Antibody type: Polyclonal
Description: KD/KO validated WT1 antibody (Cat. #12609-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

WT1 protein structure - 12609-1-AP shown in red.

Submitted references Heme oxygenase 1 (HO1) regulates autophagy and apoptosis via the PI3K/AKT/mTOR signaling pathway of yak Sertoli cells.

Yan Q, Wang Q, Nan J, Chen T, Wang J, Zhang Y, Yuan L
Theriogenology 2024 May;220:96-107

Podocyte SIRPα reduction aggravates lupus nephritis via promoting T cell inflammatory responses.

Qian B, Lu R, Mao S, Chen Y, Yang M, Zhang W, Zhang M, Zhu D, Liu Z, Zen K, Li L
Cell reports 2024 May 28;43(5):114249

Effectiveness of a novel rat model of off-target PLA2R1 knockout to renal impairment.

Huang B, Zhang Z, Sui W, Zhao L, Li Y, Feng L, Yang D, Zhou Y
Genomics 2024 Mar;116(2):110796

Predicting the prognosis of glioma patients with TERT promoter mutations and guiding the specific immune profile of immune checkpoint blockade therapy.

Cao W, Lan J, Hu C, Kong J, Xiang L, Zhang Z, Sun Y, Zeng Z, Lei S
Aging 2024 Mar 18;16(6):5618-5633

Tmem30a protects against podocyte injury through suppression of pyroptosis.

Hou Y, Chen S, Peng L, Huang L, Zhang H, Zhang P, Yu M, Xiong L, Zhong X, Liu W, Zhu X, Wang L, Li Y, Li G
iScience 2024 Jun 21;27(6):109976

Photosynthetic Bacteria-Hitchhiking 2D iMXene-mRNA Vaccine to Enable Photo-Immunogene Cancer Therapy.

Zhang S, Yu J, Liu Y, Xiong B, Fang Y, Zhu Y, Li S, Sun L, Zhou B, Sun Y, Wang L, Yue W, Yin H, Xu H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jul;11(28):e2307225

Wilms' tumor 1 (WT1) antigen is overexpressed in Kaposi Sarcoma and is regulated by KSHV vFLIP.

Morales AE, Gumenick R, Genovese CM, Jang YY, Ouedraogo A, Ibáñez de Garayo M, Pannellini T, Patel S, Bott ME, Alvarez J, Mun SS, Totonchy J, Gautam A, Delgado de la Mora J, Chang S, Wirth D, Horenstein M, Dao T, Scheinberg DA, Rubinstein PG, Semeere A, Martin J, Godfrey CC, Moser CB, Matining RM, Campbell TB, Borok MZ, Krown SE, Cesarman E
PLoS pathogens 2024 Jan;20(1):e1011881

WT1(+) glomerular parietal epithelial progenitors promote renal proximal tubule regeneration after severe acute kidney injury.

Hong X, Nie H, Deng J, Liang S, Chen L, Li J, Gong S, Wang G, Zuo W, Hou F, Zhang F
Theranostics 2023;13(4):1311-1324

A Nucleus-Targeting WT1 Antagonistic Peptide Encapsulated in Polymeric Nanomicelles Combats Refractory Chronic Myeloid Leukemia.

Chen M, Fang X, Du R, Meng J, Liu J, Liu M, Yang Y, Wang C
Pharmaceutics 2023 Sep 12;15(9)

An immune signature to predict the prognosis of ATRX-wildtype glioma patients and guide immune checkpoint blockade therapy.

Cao W, Sun P, Luo S, Zeng Z, Xiao C, Yu W, Lei S
Aging 2023 Oct 6;15(19):10453-10472

Stromal cells-specific retinoic acid determines parturition timing at single-cell and spatial-temporal resolution.

Zhao H, Wang Y, Xu H, Liu M, Xu X, Zhu S, Liu Z, Cai H, Wang Y, Lu J, Yang X, Kong S, Bao H, Wang H, Deng W
iScience 2023 Oct 20;26(10):107796

Apolipoprotein L1 (APOL1) cation current in HEK-293 cells and in human podocytes.

Vandorpe DH, Heneghan JF, Waitzman JS, McCarthy GM, Blasio A, Magraner JM, Donovan OG, Schaller LB, Shah SS, Subramanian B, Riella CV, Friedman DJ, Pollak MR, Alper SL
Pflugers Archiv : European journal of physiology 2023 Mar;475(3):323-341

Zearalenone induces oxidative stress and autophagy in goat Sertoli cells.

Liu X, Xi H, Han S, Zhang H, Hu J
Ecotoxicology and environmental safety 2023 Mar 1;252:114571

Genome Engineering of Human Urine-Derived Stem Cells to Express Lactoferrin and Deoxyribonuclease.

Kenigsberg Z, Welch RC, Bejoy J, Williams FM, Veach RA, Jarrett I, Thompson TK, Wilson MH, Woodard LE
Tissue engineering. Part A 2023 Jul;29(13-14):372-383

Enhanced autophagy reversed aflatoxin B1-induced decrease in lactate secretion of dairy goat Sertoli cells.

Han S, Zhang H, Liu X, Wen F, Li B, Bie Z, Qiu H, Hu J
Ecotoxicology and environmental safety 2023 Jul 1;259:115063

FSH-inhibited autophagy protects against oxidative stress in goat Sertoli cells through p62-Nrf2 pathway.

Xi H, Hu Z, Han S, Liu X, Wang L, Hu J
Theriogenology 2023 Jan 1;195:103-114

Paeoniflorin directly binds to TNFR1 to regulate podocyte necroptosis in diabetic kidney disease.

Wang X, Liu XQ, Jiang L, Huang YB, Zeng HX, Zhu QJ, Qi XM, Wu YG
Frontiers in pharmacology 2022;13:966645

Paeoniflorin binds to VEGFR2 to restore autophagy and inhibit apoptosis for podocyte protection in diabetic kidney disease through PI3K-AKT signaling pathway.

Wang X, Jiang L, Liu XQ, Huang YB, Wang AL, Zeng HX, Gao L, Zhu QJ, Xia LL, Wu YG
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Nov;106:154400

Targeting APLN/APJ restores blood-testis barrier and improves spermatogenesis in murine and human diabetic models.

Song K, Yang X, An G, Xia X, Zhao J, Xu X, Wan C, Liu T, Zheng Y, Ren S, Wang M, Chang G, Cronin SJF, Penninger JM, Jing T, Ou X, Rao S, Liu Z, Zhao XY
Nature communications 2022 Nov 28;13(1):7335

Restoration of WT1/miR-769-5p axis by HDAC1 inhibition promotes MMT reversal in mesenchymal-like mesothelial cells.

Bontempi G, Terri M, Garbo S, Montaldo C, Mariotti D, Bordoni V, Valente S, Zwergel C, Mai A, Marchetti A, Domenici A, Menè P, Battistelli C, Tripodi M, Strippoli R
Cell death & disease 2022 Nov 17;13(11):965

USP13 promotes development and metastasis of high-grade serous ovarian carcinoma in a novel mouse model.

Kwon J, Choi H, Ware AD, Morillo BC, Wang H, Bouker KB, Lu X, Waldman T, Han C
Oncogene 2022 Mar;41(13):1974-1985

Non-canonical Wnt/calcium signaling is protective against podocyte injury and glomerulosclerosis.

Zhou D, Wang Y, Gui Y, Fu H, Zhou S, Wang Y, Bastacky SI, Stolz DB, Liu Y
Kidney international 2022 Jul;102(1):96-107

FSH inhibits autophagy and lysosomal biogenesis to regulate protein degradation in cultured goat Sertoli cells.

Xi H, Ren F, Li Y, Xian M, Wang L, Hu J
Molecular and cellular endocrinology 2022 Jan 15;540:111505

WT1 suppresses follicle-stimulating hormone-induced progesterone secretion by regulating ERK1/2 pathway in chicken preovulatory granulosa cells.

Tang S, Li X, Wu X, Gong Y
Gene 2022 Feb 20;812:146097

Pleural Mesothelial Cells Modulate the Inflammatory/Profibrotic Response During SARS-CoV-2 Infection.

Matusali G, Trionfetti F, Bordoni V, Nardacci R, Falasca L, Colombo D, Terri M, Montaldo C, Castilletti C, Mariotti D, Del Nonno F, Capobianchi MR, Agrati C, Tripodi M, Strippoli R
Frontiers in molecular biosciences 2021;8:752616

Silencing of PFKFB3 protects podocytes against high glucose‑induced injury by inducing autophagy.

Zhu Z, Liu Q, Sun J, Bao Z, Wang W
Molecular medicine reports 2021 Nov;24(5)

Changes in histology, protein expression, and autophagy in dairy goat testes during nonbreeding season†.

Xi H, Ren F, Li Y, Du Y, Wang L, Hu J
Biology of reproduction 2021 Nov 15;105(5):1344-1354

The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma.

Heider M, Eichner R, Stroh J, Morath V, Kuisl A, Zecha J, Lawatscheck J, Baek K, Garz AK, Rudelius M, Deuschle FC, Keller U, Lemeer S, Verbeek M, Götze KS, Skerra A, Weber WA, Buchner J, Schulman BA, Kuster B, Fernández-Sáiz V, Bassermann F
Molecular cell 2021 Mar 18;81(6):1170-1186.e10

Genome profiling of mismatch repair genes in eight types of tumors.

Wang S, Guan G, Zou C, Guo Q, Cheng W, Shen S, Dong F, Wu A, Li G, Zhu C
Cell cycle (Georgetown, Tex.) 2021 Jun;20(11):1091-1106

Accelerated protocol for the differentiation of podocytes from human pluripotent stem cells.

Bejoy J, Qian ES, Woodard LE
STAR protocols 2021 Dec 17;2(4):100898

Brain-specific Wt1 deletion leads to depressive-like behaviors in mice via the recruitment of Tet2 to modulate Epo expression.

Ji F, Wang W, Feng C, Gao F, Jiao J
Molecular psychiatry 2021 Aug;26(8):4221-4233

Inhibition of Aurora Kinase B attenuates fibroblast activation and pulmonary fibrosis.

Kasam RK, Ghandikota S, Soundararajan D, Reddy GB, Huang SK, Jegga AG, Madala SK
EMBO molecular medicine 2020 Sep 7;12(9):e12131

Induction of Sertoli-like cells from human fibroblasts by NR5A1 and GATA4.

Liang J, Wang N, He J, Du J, Guo Y, Li L, Wu W, Yao C, Li Z, Kee K
eLife 2019 Nov 11;8

Yes-associated protein regulates podocyte cell cycle re-entry and dedifferentiation in adriamycin-induced nephropathy.

Xie K, Xu C, Zhang M, Wang M, Min L, Qian C, Wang Q, Ni Z, Mou S, Dai H, Pang H, Gu L
Cell death & disease 2019 Dec 4;10(12):915

Analysis of Circulating Tumor Cells in Ovarian Cancer and Their Clinical Value as a Biomarker.

Zhang X, Li H, Yu X, Li S, Lei Z, Li C, Zhang Q, Han Q, Li Y, Zhang K, Wang Y, Liu C, Mao Y, Wang X, Irwin DM, Guo H, Niu G, Tan H
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;48(5):1983-1994

Wilms' tumor 1 drives fibroproliferation and myofibroblast transformation in severe fibrotic lung disease.

Sontake V, Kasam RK, Sinner D, Korfhagen TR, Reddy GB, White ES, Jegga AG, Madala SK
JCI insight 2018 Aug 23;3(16)

YAP induces high-grade serous carcinoma in fallopian tube secretory epithelial cells.

Hua G, Lv X, He C, Remmenga SW, Rodabough KJ, Dong J, Yang L, Lele SM, Yang P, Zhou J, Karst A, Drapkin RI, Davis JS, Wang C
Oncogene 2016 Apr 28;35(17):2247-65

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The WT1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human WT1. This antibody recognizes human, mouse, rat antigen. The WT1 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 12609-1-AP.pdf

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