12609-1-AP

antibody from Proteintech Group

Targeting: WT1 AWT1, GUD, NPHS4, WAGR, WIT-2

Provider product page for 12609-1-AP

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Antibody Data
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References [66]
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Product number: 12609-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#12609-1-AP, RRID:AB_2216225
Product name: WT1 antibody
Antibody type: Polyclonal
Description: KD/KO validated WT1 antibody (Cat. #12609-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

WT1 protein structure - 12609-1-AP shown in red.

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Postmortem diagnosis of exocrine pancreatic adenocarcinoma mimicking encapsulating peritoneal sclerosis in a cat: Clinical and histopathological insights.

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Huaiqihuang (HQH) protects podocytes from high glucose-induced apoptosis and inflammation response by regulating PI3K/AKT/mTOR pathway.

Zhang P, Liu Z, Ma G, Wang J, Shao J, Ma C, Wang L, Ma C
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Du L, Cui Y, Chen W, Li C, He Z
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Nicotinamide ameliorates podocyte injury and albuminuria in adriamycin-induced nephropathy.

Takahashi K, Sato E, Yamakoshi S, Ogane M, Sekimoto A, Ishikawa T, Kisu K, Oe Y, Okamoto K, Miyazaki M, Tanaka T, Takahashi N
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Wang HQ, Wu HX, Shi WQ, Yang Y, Lin M, Wang K, Bian CC, An XF, Wang T, Yan M
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Yan Q, Wang Q, Nan J, Chen T, Wang J, Zhang Y, Yuan L
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Podocyte SIRPα reduction aggravates lupus nephritis via promoting T cell inflammatory responses.

Qian B, Lu R, Mao S, Chen Y, Yang M, Zhang W, Zhang M, Zhu D, Liu Z, Zen K, Li L
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Tmem30a protects against podocyte injury through suppression of pyroptosis.

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Wilms' tumor 1 (WT1) antigen is overexpressed in Kaposi Sarcoma and is regulated by KSHV vFLIP.

Morales AE, Gumenick R, Genovese CM, Jang YY, Ouedraogo A, Ibáñez de Garayo M, Pannellini T, Patel S, Bott ME, Alvarez J, Mun SS, Totonchy J, Gautam A, Delgado de la Mora J, Chang S, Wirth D, Horenstein M, Dao T, Scheinberg DA, Rubinstein PG, Semeere A, Martin J, Godfrey CC, Moser CB, Matining RM, Campbell TB, Borok MZ, Krown SE, Cesarman E
PLoS pathogens 2024 Jan;20(1):e1011881

The inhibition of rutin on Src kinase blocks high glucose-induced EGFR/ERK transactivation in diabetic nephropathy by integrative approach of network pharmacology and experimental verification.

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EWS-WT1 fusion isoforms establish oncogenic programs and therapeutic vulnerabilities in desmoplastic small round cell tumors.

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WT1(+) glomerular parietal epithelial progenitors promote renal proximal tubule regeneration after severe acute kidney injury.

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Theranostics 2023;13(4):1311-1324

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Ecotoxicology and environmental safety 2023 Jul 1;259:115063

FSH-inhibited autophagy protects against oxidative stress in goat Sertoli cells through p62-Nrf2 pathway.

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Paeoniflorin binds to VEGFR2 to restore autophagy and inhibit apoptosis for podocyte protection in diabetic kidney disease through PI3K-AKT signaling pathway.

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Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Nov;106:154400

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Song K, Yang X, An G, Xia X, Zhao J, Xu X, Wan C, Liu T, Zheng Y, Ren S, Wang M, Chang G, Cronin SJF, Penninger JM, Jing T, Ou X, Rao S, Liu Z, Zhao XY
Nature communications 2022 Nov 28;13(1):7335

Restoration of WT1/miR-769-5p axis by HDAC1 inhibition promotes MMT reversal in mesenchymal-like mesothelial cells.

Bontempi G, Terri M, Garbo S, Montaldo C, Mariotti D, Bordoni V, Valente S, Zwergel C, Mai A, Marchetti A, Domenici A, Menè P, Battistelli C, Tripodi M, Strippoli R
Cell death & disease 2022 Nov 17;13(11):965

USP13 promotes development and metastasis of high-grade serous ovarian carcinoma in a novel mouse model.

Kwon J, Choi H, Ware AD, Morillo BC, Wang H, Bouker KB, Lu X, Waldman T, Han C
Oncogene 2022 Mar;41(13):1974-1985

Non-canonical Wnt/calcium signaling is protective against podocyte injury and glomerulosclerosis.

Zhou D, Wang Y, Gui Y, Fu H, Zhou S, Wang Y, Bastacky SI, Stolz DB, Liu Y
Kidney international 2022 Jul;102(1):96-107

FSH inhibits autophagy and lysosomal biogenesis to regulate protein degradation in cultured goat Sertoli cells.

Xi H, Ren F, Li Y, Xian M, Wang L, Hu J
Molecular and cellular endocrinology 2022 Jan 15;540:111505

WT1 suppresses follicle-stimulating hormone-induced progesterone secretion by regulating ERK1/2 pathway in chicken preovulatory granulosa cells.

Tang S, Li X, Wu X, Gong Y
Gene 2022 Feb 20;812:146097

Pleural Mesothelial Cells Modulate the Inflammatory/Profibrotic Response During SARS-CoV-2 Infection.

Matusali G, Trionfetti F, Bordoni V, Nardacci R, Falasca L, Colombo D, Terri M, Montaldo C, Castilletti C, Mariotti D, Del Nonno F, Capobianchi MR, Agrati C, Tripodi M, Strippoli R
Frontiers in molecular biosciences 2021;8:752616

Silencing of PFKFB3 protects podocytes against high glucose‑induced injury by inducing autophagy.

Zhu Z, Liu Q, Sun J, Bao Z, Wang W
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Changes in histology, protein expression, and autophagy in dairy goat testes during nonbreeding season†.

Xi H, Ren F, Li Y, Du Y, Wang L, Hu J
Biology of reproduction 2021 Nov 15;105(5):1344-1354

The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma.

Heider M, Eichner R, Stroh J, Morath V, Kuisl A, Zecha J, Lawatscheck J, Baek K, Garz AK, Rudelius M, Deuschle FC, Keller U, Lemeer S, Verbeek M, Götze KS, Skerra A, Weber WA, Buchner J, Schulman BA, Kuster B, Fernández-Sáiz V, Bassermann F
Molecular cell 2021 Mar 18;81(6):1170-1186.e10

Genome profiling of mismatch repair genes in eight types of tumors.

Wang S, Guan G, Zou C, Guo Q, Cheng W, Shen S, Dong F, Wu A, Li G, Zhu C
Cell cycle (Georgetown, Tex.) 2021 Jun;20(11):1091-1106

Accelerated protocol for the differentiation of podocytes from human pluripotent stem cells.

Bejoy J, Qian ES, Woodard LE
STAR protocols 2021 Dec 17;2(4):100898

Brain-specific Wt1 deletion leads to depressive-like behaviors in mice via the recruitment of Tet2 to modulate Epo expression.

Ji F, Wang W, Feng C, Gao F, Jiao J
Molecular psychiatry 2021 Aug;26(8):4221-4233

Inhibition of Aurora Kinase B attenuates fibroblast activation and pulmonary fibrosis.

Kasam RK, Ghandikota S, Soundararajan D, Reddy GB, Huang SK, Jegga AG, Madala SK
EMBO molecular medicine 2020 Sep 7;12(9):e12131

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Liang J, Wang N, He J, Du J, Guo Y, Li L, Wu W, Yao C, Li Z, Kee K
eLife 2019 Nov 11;8

Yes-associated protein regulates podocyte cell cycle re-entry and dedifferentiation in adriamycin-induced nephropathy.

Xie K, Xu C, Zhang M, Wang M, Min L, Qian C, Wang Q, Ni Z, Mou S, Dai H, Pang H, Gu L
Cell death & disease 2019 Dec 4;10(12):915

Analysis of Circulating Tumor Cells in Ovarian Cancer and Their Clinical Value as a Biomarker.

Zhang X, Li H, Yu X, Li S, Lei Z, Li C, Zhang Q, Han Q, Li Y, Zhang K, Wang Y, Liu C, Mao Y, Wang X, Irwin DM, Guo H, Niu G, Tan H
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;48(5):1983-1994

Wilms' tumor 1 drives fibroproliferation and myofibroblast transformation in severe fibrotic lung disease.

Sontake V, Kasam RK, Sinner D, Korfhagen TR, Reddy GB, White ES, Jegga AG, Madala SK
JCI insight 2018 Aug 23;3(16)

YAP induces high-grade serous carcinoma in fallopian tube secretory epithelial cells.

Hua G, Lv X, He C, Remmenga SW, Rodabough KJ, Dong J, Yang L, Lele SM, Yang P, Zhou J, Karst A, Drapkin RI, Davis JS, Wang C
Oncogene 2016 Apr 28;35(17):2247-65

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The WT1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human WT1. This antibody recognizes human, mouse, rat antigen. The WT1 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 12609-1-AP.pdf

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