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- Product number
- 10442-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10442-1-AP, RRID:AB_2206609
- Product name
- P53 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated P53 antibody (Cat. #10442-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, rat, mouse and has been validated for the following applications: IF, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references NAT10 Promotes Tubular Epithelial Cell Senescence in Cisplatin-Induced Acute Kidney Injury by Regulating DDX17.
X-Box Binding Protein 1 Regulates Osteogenesis of Periodontal Ligament Cells During Aging by Modulating P53 Signaling Pathway.
Bioinformatic Identification and Preliminary Validation of TP53, TGFB1, and NFE2L2 as Potential Ferroptosis-Related Regulators in Pancreatic Adenocarcinoma.
Aging Inhibits Emergency Angiogenesis and Exacerbates Neuronal Damage by Downregulating DARS2.
Actinidia chinensis Planch Root extracts trigger ferroptosis in colorectal cancer via the p53/SLC7A11/GPX4 axis.
UBE2W promotes pancreatic cancer progression through regulating K63-linked ubiquitination of p53.
Tumor Prostate-Specific Antigen Density Can Predict Tumor Aggressiveness and Heterogeneity in Prostate Cancer.
Longitudinal prediction of drug response in high-grade serous ovarian cancer organoid cultures aligning with clinical responses.
On-demand mild photothermal cascade platform reprogramming mitochondrial immunity for tendon rejuvenation.
Periplogenin Suppresses Hepatocarcinogenesis by Inducing Cellular Senescence via the Activating FOXO1/P53 Signaling Pathway.
Characteristics of chromosomal instability‑related lncRNAs associated with progression and prognosis in breast cancer.
Integrating network toxicology and experimental validation to elucidate the molecular mechanism basis of chondrotoxicity of Benzo[a]pyrene in osteoarthritis.
Cinnamyl Alcohol Attenuates Osteoarthritis Progression via PIGR-Mediated Regulation of Chondrocyte Senescence and Cartilage Homeostasis.
Dihydroartemisinin-Loaded ZIF-8 Nanoparticles Elicit Chemo-Immunotherapy against Malignant Pleural Effusion via Inhibition of OCT4/M-CSF Signaling Pathway.
Small molecule HCY-NBD stabilizes GSTM2 via cys174 sulfenylation to attenuate high glucose induced endothelial cell senescence and calcification.
Prenylterphenyllin, a regulator of P53, inhibits colorectal cancer progression through oxidative stress and energy metabolism pathway.
Role of ITIH4 in Modulating YAP/TAZ-Mediated Apoptosis of Type II Alveolar Epithelium during Acute Respiratory Distress Syndrome.
Hypoxia-preconditioned bone marrow mesenchymal stem cell-derived exosomes ameliorate knee osteoarthritis by promoting cartilage regeneration and alleviating pain in rats.
The anti-aging drug Senolytics alleviates vascular endothelial cell senescence by antagonizing the JPX-BRD4-p65 complex.
YTHDF3-TRIM2-P53 axis promotes malignant progression in uveal melanoma (UVM).
Neddylation Targets and Stabilizes NLRP3 to Augment Inflammasome-Mediated Colitis and Mood Disorder.
Fibroblast growth factor-inducible 14 accelerates pulmonary fibrosis by inducing fibroblast senescence in mice.
Zearalenone Induces Oxidative Stress and Apoptosis in the Jejunum of Weaned Piglets via the p53/Nrf2 Signaling Pathway.
Unraveling the Molecular Mechanisms Linking Cigarette Smoke Exposure to Skin Damage.
Mutant p53 Directs PARP to Regulate Replication Stress and Drive Breast Cancer Metastasis.
Peroxiredoxin 4 Involved in Spermatogenesis by Affecting Oxidative Stress and Ferroptosis.
Mechanism of platelet-rich plasma inhibiting inflammatory response, oxidative stress, and senescence in synovial fibroblasts of patients with knee osteoarthritis via UBE2C based on transcriptome sequencing analysis.
Small-molecule enhancement of METTL3 S-palmitoylation as a therapeutic strategy for osteoarthritis.
Optogenetic manipulation of estrogen receptor signaling to improve estrogen deficiency.
PCSK9 Inhibitor Alirocumab Improves Diabetic Cardiomyopathy Through the ERK/p38 MAPK Signaling Pathway.
Heme enhances B-cell proliferation and plasma cell formation through reduced p21 and Rb expression.
A novel dual-effect bimodal chip cancer research platform: Chips system interconnected vascularized tumor organoids culture with real-time exploration and detection from bench to bedside.
Targeting NAT10 alleviates colonic senescence and elderly-onset colitis by disrupting N4-acetylation of DYRK1A.
Haizao Yuhu Decoction Inhibits Goiter via p53 Pathway-Induced Apoptosis: Metabolomic and Cellular Assay Analysis.
Exploring the potential of heterocyclic-containing tail approach in the development of novel covalent inhibitors dual-targeting EGFR and HER-2: design, synthesis and biological evaluation.
Design and synthesis of novel 1,2,4-triazolobenzene sulfonamide derivatives as selective CDK1 inhibitors with potent in vivo anticancer efficacy.
Transdermal delivery of salvianolic acid B using thermosensitive hydrogel for the treatment of skin photoaging.
Metformin alleviates presbycusis by activating the SIRT1/PINK1/GPX4 pathway in vitro and in vivo.
Neuroprotective effects of SRS11-92 against oxidative stress-induced senescence via Nrf2/HO-1/NF-κB in Alzheimer's disease models.
TMEM165 promotes glioblastoma progression through epithelial-mesenchymal transition-mediated invasion and temozolomide chemoresistance.
Fe-Mn-IGF-AMD nanoparticles in accurate detection and treatment of liver cirrhosis via regulating relaxation coefficients and attenuating hepatocyte senescence.
A transcriptome-based tool for assessing skin aging reveals the ameliorative effect of stem cell-derived extracellular vesicles on UVB-induced aging.
Time-resolved multiomics profiling reveals chromatin O-GlcNAc modification promotes senescence-associated transcriptional program.
Hypoxia promotes progression of cervical cancer by modulating the ATXN3-enhanced P53 stability or STAT5 phosphorylation.
Spil-mediated sEH overexpression contributes to the senescence of alveolar epithelial cells during pulmonary fibrosis in mice.
Simiao Decoction alleviates hyperuricemia-induced renal injury through regulating gut dysbiosis and decreasing gut-derived uremic toxins.
Elucidation of the potential molecular mechanisms of Buyang Huanwu Decoction in delaying cardiac aging: Based on network pharmacology, bioinformatics, and in vivo/in vitro experimental validation.
The p53 R181C mutation accumulates through impaired deacetylation by Sirt1 and facilitates tumor development.
SCHEMBL4796824: a multifaceted antitumor agent targeting microtubule dynamics, DNA damage, and Wnt/β-catenin signaling in ovarian cancer cells.
Ad-VT oncolytic adenovirus suppresses bladder cancer via cAMP-dependent AMPK-Raptor activation and G2/M arrest.
Plasma-activated solutions reverse chronic deltamethrin exposure induced intestinal injury via rebalancing redox homeostasis and counteracting cellular senescence.
GMCL1 controls 53BP1 stability and modulates taxane sensitivity.
Fullerenol Eye Drops Mitigate UVB-Induced Cataract Progression by Inhibiting Oxidative Stress and Cellular Senescence.
Bioswitchable intracellular delivery of small activating RNA by tetrahedral framework nucleic acid: Application to p21-mediated anti-tumor therapy.
Inhibition of the PI3K/AKT signaling pathway blocks the oncogenic activity of TRIM26 in prostate cancer cells.
Catalpol attenuates postmenopausal osteoporosis by activating SIRT1-mediated P53 deacetylation and inhibiting CASPASE-3-driven osteoblast apoptosis.
FBXO5 alleviates apical periodontitis by facilitating TP53 protein degradation.
Hsa-miR-526b-5p Regulates the Sensitivity of Colorectal Cancer to 5-Fluorouracil by Targeting TP53 in Organoid Models.
Porphyromonas gingivalis Outer Membrane Vesicles Promote Gingival Fibroblasts Senescence via IL21R-AS1.
Integrating TWAS, chemical-genomic networks, and experimental models: melatonin as a ferroptosis inhibitor in osteoarthritis therapy.
A Human Kidney Tubuloid Model of Repeated Cisplatin-Induced Cellular Senescence and Fibrosis for Drug Screening.
Remodeling Cellular Uptake via Inducing Clustering of Urokinase Receptors in Hydrogel Microspheres for Alleviating Cartilage Senescence.
WTAP Contributes to Periodontitis Pathogenesis by Promoting PDLSC Senescence and Impairing Osteogenic Differentiation via m6A-Dependent Regulation of TP53BP1.
A Unique Chimeric RNA: ERCC1-iASPP Drives Benzo[a]pyrene-Induced Lung Carcinogenesis via Dual Coding and Non-Coding Mechanisms.
Removing therapy-induced senescent cancer cells targets and potentiates the response of pancreatic cancer cells toward PARP inhibitors as maintenance therapy.
UBA5 deficiency disrupts mitochondrial autophagy via the PINK1-parkin pathway and impairs myoblast proliferation.
Characterization of Novel Decenoic Acid Derivatives Exhibiting Cytotoxic Activity Against T98G Glioma Cells Under a Serum- and Glucose-deprived Condition.
Cardiospermum halicacabum Extract Attenuates UVB-Induced Photoaging in Human Skin Fibroblasts via Inhibition of the PI3K/Akt/mTOR Signaling Pathway.
Mechanistic Insights into Active Components of Rosa Roxburghii Juice Against Fluoride-Induced Osteoarthritis.
Pramipexole alleviates ferroptosis in HT22 cells induced by oxygen-glucose deprivation/reoxygenation via the Nrf2/SLC7A11/GPX4 pathway.
The SIRT1-Mediated p53 Deacetylation Pathway Modulates Apoptosis and Promotes Viral Replication in MVC-Infected Cells.
Preparation of Artemisia argyi-Derived Extracellular Nanovesicles and Their Protective Effects Against Oxidative Stress-Induced Senescence in Endometrial Stromal Cells.
Curcumin-loaded silk fibroin scaffold promotes cartilage regeneration by inhibiting angiogenesis via Drp1/ROS-mediated mitochondrial regulation.
Synergistic microenvironment therapy: a dual-function nanogel of supramolecular collagen ll-mimetic matrix and antioxidant MXene for attenuating intervertebral disc degeneration.
p53 regulates early mucosal immunity via antigen presentation in zebrafish intestine post-SVCV vaccination.
T-cell apoptosis is more susceptible to overactivated neutrophils delivered-NETs-MPO/NE complex.
Pregnane X receptor mitigates aristolochic acid-induced acute kidney injury via p53 ubiquitination.
Identification of mitochondrial permeability transition-related gene signatures to predict lung adenocarcinoma survival and drug response.
Engineered extracellular vesicles from human placental mesenchymal stem cells attenuate abdominal aortic aneurysm formation by inhibiting Nat10-mediated vascular smooth muscle cell senescence.
RFRP-3 suppresses ovarian granulosa cell function in Tan sheep via dual signaling pathways: PI3K/AKT/mTOR and MAPK/ERK1/2.
TP53 links mitochondria-endoplasmic reticulum crosstalk and ferroptosis in septic cardiomyopathy: Protective modulation by nicorandil.
Kaempferol Mitigates Liver Injury Induced by Copper Toxicity Through the Activation of the Sirt1/Nrf2/FOXO3 Signaling Pathway.
PLLP inhibits the progression of WT p53 gastric cancer by reducing p53 protein ubiquitination by binding to TRIM59.
SLC2A3-Mediated Lactate Metabolism Promotes Lung Cancer Bone Metastasis by Modulating P53 Lactylation and Immune Evasion.
KRAB Zinc-Finger Protein ZNF205 Promotes Hepatocellular Carcinoma via p53 Pathway Repression.
GL-V9 disrupts the mitochondrial homeostasis and triggers the integrated stress response by promoting the binding of cytosolic MDM2 with NDUFS1 in colorectal cancer.
Triple-Targeted Peptide-Photosensitizer-Drug Conjugate Enables NIR-II Imaging-Guided Multimodal Therapy Against Osteosarcoma.
Multiomics profiling and experiments in preclinical models revealed RAD51-IN-1 as a synergistic potentiator of anlotinib sensitivity.
KLOTHO Deficiency Drives Ovarian Aging by Inducing Granulosa Cell Senescence and Dysfunction.
Peroxisome-derived and liver-specific hydroxyacid oxidase 1-mediated hydrogen peroxide promotes ferroptosis by augmenting peroxisomal ROS.
FBXO39 promotes LDHA-mediated aerobic glycolysis and colorectal cancer progression by p53 degradation.
Youthful Brain-Derived Extracellular Vesicle-Loaded GelMA Hydrogel Promotes Scarless Wound Healing in Aged Skin by Modulating Senescence and Mitochondrial Function.
Quercetin, a Natural Dietary Flavonoid, Emerges a Novel USP7 Inhibitor with Anti-colorectal Cancer Effects.
DARS2 Promotes Bladder Cancer Progression by Enhancing PINK1-Mediated Mitophagy.
Exendin-4 Reduces Senescence of Inflammation-Induced Periodontal Ligament Stem Cells Through SIRT1/Notch1 Signaling.
Bionic Power Play: Dual-Targeting MDMX/MDM2 to Reboot p53 to Beat Lung Adenocarcinoma's Immune Tricks.
Tetrahedral Framework Nucleic Acids Inhibit Oxidative Stress and Cardiomyocyte Apoptosis in Doxorubicin-Induced Cardiotoxicity.
Boron Phenylalanine-Modified Polydopamine Nanoparticles for Targeted Delivery of Danusertib in Non-Small Cell Lung Cancer.
MAP17 is a Novel NASH Progression Biomarker Associated with Macrophage Infiltration, Immunotherapy Response, and Oxidative Stress.
TRIM6 Promotes Cell Cycle and Growth by Modulating p53 Signaling Pathway in Lung Adenocarcinoma.
Acupotomy Ameliorates KOA Related Chondrocyte Premature Senescence Through YAP/FOXD1 Pathway.
Astragaloside IV Alleviates Osteoarthritis by Inhibiting Chondrocyte Ferroptosis via the p53/SLC7A11/GPX4 Axis.
Fatty Acid Transporter CD36 Promotes Ox-LDL-Induced Senescence of Vascular Endothelial Cells in Preeclampsia.
Ginsenoside Rg3 exerts anticancer effects in lung cancer through metabolite Histon H3.
Carnosic acid attenuates diabetic retinopathy via the SIRT1 signaling pathway: neuroprotection and endothelial cell preservation.
GDF15 is associated with thyroid cancer progression and may modulate thyroid cancer cell senescence in a p53-dependent manner.
Identification of an Ara-C resistance-related gene risk score and the role of S100A4 in AML via NR6A1-dependent activation and p53 regulation.
Synergistic effects of retinol and retinyl palmitate in alleviating UVB-induced DNA damage and promoting the homologous recombination repair in keratinocytes.
Dehydrodiisoeugenol targets the PLK1-p53 axis to inhibit breast cancer cell cycle.
Saikosaponin A induces cellular senescence in triple-negative breast cancer by inhibiting the PI3K/Akt signalling pathway.
Gallic acid protects intervertebral disc cells from ferroptosis and alleviates intervertebral disc degeneration by regulating key factors of oxidative stress.
Targeting the N-cadherin/β-catenin axis with MSAB reverses malignant phenotypes in blast crisis of CML.
Repurposing riluzole as an anti-osteosarcoma agent.
IL-6/GATA2/SERPINE1 pathway is implicated in regulating cellular senescence after acute kidney injury.
Impaired stemness in aging periodontal ligament stem cells is mediated by the progerin/endoplasmic reticulum stress/p53 axis.
3-Indolepropionic acid confers PXR-p53 binding to mitigate deoxynivalenol-induced hepatocyte apoptosis.
Phytosphingosine Alleviates Cigarette Smoke-Induced Bronchial Epithelial Cell Senescence in Chronic Obstructive Pulmonary Disease by Targeting the Free Fatty Acid Receptor 4.
Notoginsenoside R2 attenuates hepatic fibrosis via STAT3-dependent hepatic stellate cells senescence induction and inflammatory microenvironment suppression.
ACSL5 regulated acetyl-CoA to promote bladder cancer cellular senescence via 53BP1 acetylation.
Exploring the potential mechanism of atorvastatin in regulating ferroptosis as a treatment for heart failure based on network pharmacology.
Ubiquitin-specific protease 7-mediated stabilization of discoidin domain receptor 1 drives progression of TP53-Mutant cancers.
Comprehensive Pan-Cancer Analysis of TRNT1 as a Potential Biomarker for Breast Cancer.
Glutaredoxin 1 enhances endothelial cell angiogenesis by reducing VEGFA S-glutathionylation and delays vascular endothelial cell senescence.
A genome-wide analysis of YY1 and TFAP2 competition on overlapping motifs reveals their roles in HPV-induced carcinogenesis.
Energy metabolism disturbance induced by atorvastatin exposure on yellowstripe goby (Mugilogobius chulae) larvae based on transcriptome and metabolome analysis.
Suppressed autophagy of thymic cells promotes apoptosis and thymic atrophy in COPD.
MKRN2 attenuates LPS-induced apoptosis in lung epithelial cells via ubiquitination-mediated p53 degradation.
Nuclear FGF2 orchestrates phase separation-mediated rDNA chromatin architecture to control BMSCs cell fate.
NGAL knockdown alleviated CSE-induced cellular senescence and reduced MMP2 and MMP9 expression in alveolar macrophages through the PI3K/Akt pathway.
Melatonin attenuates ischemia-reperfusion-induced acute kidney injury by regulating abnormal autophagy and pyroptosis through SIRT1-mediated p53 deacetylation.
Colla Corii Asini regulate collagen regeneration in UV exposure-induced skin photoaging in mice.
Arylsulfatase K attenuates airway epithelial cell senescence in COPD by regulating parkin-mediated mitophagy.
cZFP609 Tethering BiP Alleviates Cartilage Degradation in Osteoarthritis via Remedying Aberrant ER-Mitochondrial Contacts.
WTAP Silencing protects human aortic smooth muscle cells from angiotensin II-induced senescence, apoptosis, ferroptosis, and inflammation by regulating PCSK9.
Canagliflozin improves high-salt-induced aortic arteriosclerosis and premature aging in dahl salt-sensitive rats through the SIRT6/HIF-1 α signaling pathway.
Hydrogen Sulfide Ameliorates Heart Aging by Downregulating Matrix Metalloproteinase-9.
Centipede Polypeptide Affects the Inflammatory Reaction and Ferroptosis of Liver Cancer Cells Through the p53/TRAIL Pathway.
cTAGE5/MEA6 Regulates LBR Localization to Maintain Nuclear Envelope Integrity and Safeguard Against Aging.
Arginyl-fructosyl-glucose (AFG), a major Maillard reaction product of red ginseng, improved kidney and pancreatic injury in vitro and in vivo in type 2 diabetes mellitus.
Neuronal pentraxin 1 accelerates post-stroke atherosclerosis by inducing endothelial cell senescence.
α-hederin inhibits cervical cancer progression by inducing DNA damage-dependent cell cycle blockade and apoptosis.
Luteoloside alleviates bleomycin-induced pulmonary fibrosis in mice via SIRT1-mediated protective effect against alveolar epithelial cell senescence.
Novel E-F ring derivatives of aconitine scaffold as potent Hsp90 inhibitors for the treatment of colorectal cancer.
PARP1 promoter hypermethylation promotes arsenic-induced skin damage by driving telomere dysfunction-mediated keratinocyte senescence.
Transcriptomic Analysis of the Effects of Hydroxysafflor Yellow A on hUC-MSC Senescence via the ECM-Receptor Interaction Pathway.
Harnessing TP73‑targeted nintedanib: A novel strategy to halt triple‑negative breast cancer via p53‑PPARα/PI3K‑Akt pathway suppression.
RIPK4-p53 interaction drives aflatoxin B1-induced renal mitochondrial apoptosis via Ser15 phosphorylation: A CRISPR-Cas9 mechanistic study.
Structural characterization and functional role of SLC7A6 in GSSG transport and Ferroptosis regulation.
Autophagic damage in senescent bone marrow mesenchymal stromal cells: Impact on Piezo1 expression during osteoporosis progression.
Targeting LARP1 to mitigate aging in lens epithelial cells: mechanistic insights into mitochondrial dysfunction.
NSUN6 Promotes Gastric Cancer Progression by Stabilizing CEBPZ mRNA in a m(5)C-Dependent Manner.
Establishment and characterization of canine mammary tumors 622: A novel luminal B CMT cell line exhibiting partial epithelial-mesenchymal transition and intermediate drug sensitivity.
Biotransformation of steroid hormones by intestinal fungi and their special cytotoxicity on HeLa cancer cells.
Organoid-based two-step drug screening for rapid identification of chemotherapy-resistant oesophageal squamous cell carcinoma and alternative therapies.
Dendrobin A inhibits gastric cancer: Mechanistic insights supported by integrated evidence.
Hydrogen sulfide alleviates vascular smooth muscle cell senescence by inhibiting endoplasmic reticulum stress.
CX-5461 inhibits cell proliferation and induces ferroptosis of colorectal cancer cells by inactivating Nrf2 pathway.
TP53-dependent antitumor effects of DHODH Inhibition in nasopharyngeal carcinoma.
Melatonin Rescues Triclosan-Disrupted Porcine Oocyte Meiosis via Suppression of p53-Mediated Apoptosis.
Helicobacter pylori Lipopolysaccharide Upregulates MDM2 via the TLR4/MAPK/AP-1 Pathway to Promote Gastric Cancer Progression.
A serum-free adipose-conditioned medium delays stem cell senescence and maintains tissue homeostasis via IL-6/STAT3 axis suppression.
p53-mediated regulation of electron transport chain and nucleotide synthesis during Newcastle disease virus infection.
Multi-Target Botanical Complex Attenuates Cellular Senescence via Bidirectional P21/P53/SIRT1 Regulation: Dual Model Validation.
Microenvironment-responsive multifunctional enzyme-linked hydrogel for diabetic bone defect regeneration.
FTO Suppresses Dental Pulp Stem Cell Senescence by Destabilizing NOLC1 mRNA.
Integrative Transcriptomic and Metabolomic Analysis Reveals That Acanthopanax senticosus Fruit Ameliorates Cisplatin-Induced Acute Kidney Injury by Suppressing the NF-κB/PI3K-AKT Pathway via UGT1A1 Regulation.
CDC26 facilitates ferroptosis through SLC7A11 degradation and cell cycle arrest.
Mesoporous Silica Nanoparticles for Quercetin-Controlled Delivery to Protect Cisplatin-Induced Ototoxicity.
Epigenetic silencing of MSTN via m6A modification underlies the renoprotective effects of engineered MSC exosomes with RBM15 depletion in diabetic nephropathy.
Distinct functional heterogeneity of TP53 R175 mutations in platinum-resistant ovarian cancer: unveiling molecular mechanisms and therapeutic targets.
Leucokinin VIII acetate mitigates asthma severity by targeting ADCK5-induced cellular senescence.
Downregulating FGGY carbohydrate kinase domain containing promotes cell senescence by activating the p53/p21 signaling pathway in colorectal cancer.
mRNA metabolism regulator human antigen R (HuR) regulates age-related hearing loss in aged mice.
Effects of p53 on the Regulation of Carbonic Anhydrase 8 in Human Colorectal Cancer Cells: Interaction Between p53 and Sp1.
Design and Synthesis of O-Dialkylaminoalkyl Substituted Urolithin Derivatives: DNA Topoisomerase IIα Inhibition With Promising Antiproliferative Activity.
METTL3-mediated m6A modification of PAK6 drives cervical cancer progression through activating MAPK14.
An injectable multimodal thiolated carboxymethyl cellulose hydrogel for advanced gastric cancer treatment.
Praja2 controls P-body assembly and translation in glioblastoma by non-proteolytic ubiquitylation of DDX6.
Astragalin actives autophagy and inhibits apoptosis of astrocytes in AD mice via down-regulating Fas/Fasl-VDAC1 pathway.
Nicotine Ameliorates α-Synuclein Preformed Fibril-Induced Behavioral Deficits and Pathological Features in Mice.
Toosendanin-induced liver damage through irreparable DNA damage and autophagy flow blockade.
Lycium ruthenicum Murray Anthocyanins Alleviate Aging Through SIRT1/P53 Signaling Pathway.
Lithium with environmentally relevant concentrations interferes with mitochondrial function, antioxidant response, and autophagy processes in Daphnia magna, leading to changes in life-history traits and behavior.
The mechanism of telomerase Cajal body protein 1 regulating senescence of mouse bone marrow mesenchymal stem cells.
SIRT2 inhibition enhances mitochondrial apoptosis in Brucella-infected bovine placental trophoblast cells.
Therapeutic potential of Sweroside in postmenopausal osteoporosis: Inhibition of osteoclast differentiation and promotion of osteoclast apoptosis via NF-κB and MAPK pathways.
Bufei Yishen formula alleviates airway epithelial cell senescence in COPD by activating AMPK-Sirt1-FoxO3a pathway and promoting autophagy.
Targeting ADAR1 with a small molecule for the treatment of prostate cancer.
Liraglutide improves senescence and ameliorating diabetic sarcopenia via the YAP-TAZ pathway.
Investigating the role of IL-6 in the pathogenesis of systemic lupus erythematosus: Insights from bone marrow mesenchymal stem cells.
Overexpression of miR‑424‑5p reduces cisplatin resistance by downregulating SMURF1 in gastric cancer.
Anti-colorectal cancer actions of Glycyrrhiza uralensis Fisch. and its underlying mechanism via HPLC integration and network pharmacological approaches.
AP2A1 modulates cell states between senescence and rejuvenation.
Deficiency of ATF2 retards senescence induced by replication stress and pamidronate in mouse jaw bone marrow stem cells.
α-Lipoic Acid Ameliorates Arsenic-Induced Lipid Disorders by Promoting Peroxisomal β-Oxidation and Reducing Lipophagy in Chicken Hepatocyte.
Autologous platelet delivery of siRNAs by autologous plasma protein self-assembled nanoparticles for the treatment of acute kidney injury.
Characterization of Protein Expression and Signaling Pathway Activation That May Contribute to Differential Biological Functions in Porcine Arterial and Venous Smooth Muscle Cells.
Increasing cisplatin exposure promotes small-cell lung cancer transformation after a shift from glucose metabolism to fatty acid metabolism.
Systematically investigate the mechanism underlying the therapeutic effect of emodin in treatment of prostate cancer.
High-content screening identifies ganoderic acid A as a senotherapeutic to prevent cellular senescence and extend healthspan in preclinical models.
GMCL1 Controls 53BP1 Stability and Modulates Paclitaxel Sensitivity in Cancer.
MT1H inhibits the growth of gastric cancer by regulating SLC6A19/TTC39B/ADM2 and activating p53-dependent autophagy.
ACSS3 promotes the tumorigenesis of non-small cell lung cancer via suppressing p53-mediated ferroptosis.
Lycopene inhibits doxorubicin-induced heart failure by inhibiting ferroptosis through the Nrf2 signaling pathway.
To investigate the effect and mechanism of tetrahydrocurcumin on hepatocellular carcinoma based on phosphoinositide 3-kinases/AKT signaling pathway.
Discovery of Novel Oxazolo[4,3-f]purine Derivatives as Antitumor Agents through PPIA Interaction.
Baicalin reduced vandetanib induced myocardial injury by regulating redox balance and NLRP3 inflammasome pathway.
Aberrant activation of p53-TRIB3 axis contributes to diabetic myocardial insulin resistance and sulforaphane protection.
Elevation of p53 sensitizes obese kidney to adriamycin-induced aberrant lipid homeostasis via repressing HNF4α-mediated FGF21 sensitivity.
Natural compound PEITC inhibits gain of function of p53 mutants in cancer cells by switching YAP-binding partners between p53 and p73.
HNMT Promotes the Occurrence and Progression of Nasopharyngeal Carcinoma by Inhibiting the IFN/TXNIP/p53 Axis.
A novel piperine derivative HJ-23 exhibits anti-colorectal cancer effects by activating the p53 pathway.
Fe-curcumin nanozymes-mediated reactive oxygen species scavenging and anti-apoptotic effects on age-related cataracts.
Ionized Angelica polysaccharides derivatives slow tumor growth in vivo and induce the apoptosis of HepG2 cells via mitochondria death receptor-mediated pathways in vitro.
Qishiwei Zhenzhu Pills Protect Against Cerebral Ischemia via the P53/Cytochrome C/Apoptotic Protease Activating Factor 1-Mediated Mitochondrial Apoptosis Pathway.
5-HT(7)R Deficiency Alleviates ADP-Heptose-Induced Cognitive Impairment via Inhibiting Ferroptosis and Neuroinflammation in Mice.
Tripterygium wilfordii polyglycoside tablets attenuated the progression of hepatocellular carcinoma by targeting IL-6 and downstream signaling pathways in a multi-target manner.
Hydrogen sulfide preserves the function of senescent endothelium through SIRT2 mediated inflammatory inhibition.
Taurine Alleviates Pancreatic β-Cell Senescence by Inhibition of p53 Pathway.
Antitumor/anti-inflammatory effects/tissue healing as an all-in-one therapeutic strategy for nasopharyngeal carcinoma.
Polypyrrole-ferric phosphate-methotrexate nanoparticles enhance apoptosis/ferroptosis of M1 macrophages via autophagy blockage for rheumatoid arthritis treatment.
HIV Vpr activates a nucleolar-specific ATR pathway to degrade the nucleolar stress sensor CCDC137.
The long noncoding RNA RMRP-miR-3135a-SV2A axis promotes the development of hepatocellular carcinoma.
VIRMA-mediated m(6)A modification regulates forebrain formation through modulating ribosome biogenesis.
Ginsenoside Rh1 attenuates chondrocyte senescence and osteoarthritis via AMPK/PINK1/Parkin-mediated mitophagy.
Corneal Sensory Denervation Causes Epithelial Ferroptosis and Delayed Healing in Mice.
Charting the regulatory landscape of TP53 on transposable elements in cancer.
Chaperone-mediated autophagy directs a dual mechanism to balance premature senescence and senolysis to prevent intervertebral disc degeneration.
Multi-omics analysis of canine aging markers and evaluation of stem cell intervention.
Fate reversal: Exosome-driven macrophage rejuvenation and bacterial-responsive drug release for infection immunotherapy in diabetes.
RIOK1 phase separation restricts PTEN translation via stress granules activating tumor growth in hepatocellular carcinoma.
Single-Cell and Spatial Transcriptomics Identified Fatty Acid-Binding Proteins Controlling Endothelial Glycolytic and Arterial Programming in Pulmonary Hypertension.
SPATA2/CYLD Pathway-Dependent Deubiquitylation of p53 Promotes Ferroptosis in Rat Heart After Ischaemia/Reperfusion Through Suppression of SLC7A11.
ZNF451 collaborates with RNF8 to regulate RNF168 localization and amplify ubiquitination signaling to promote DNA damage repair and regulate radiosensitivity.
Mechanistic Insights Into 5'-tiRNA-His-GTG Mediated Activation of the JNK Pathway in Skin Photoaging.
Transglutaminase 2 promotes breast cancer cell autophagy by targeting p53/ mTOR axis.
Design, synthesis, and antitumor activity of novel thioheterocyclic nucleoside derivatives by suppressing the c-MYC pathway.
Synergic effect of the combination of isoliquiritigenin and arsenic trioxide in HepG2 liver cancer cells.
p38γ modulates ferroptosis in brain injury caused by ethanol and cerebral ischemia/reperfusion by regulating the p53/SLC7A11 signaling pathway.
Role and Mechanism of Astragalus Monomer Quercetin in Modulating Akt/Bcl-2 Pathway to Improve Ventricular Remodeling in Chronic Heart Failure.
Early-life exercise extends healthspan but not lifespan in mice.
A cancer persistent DNA repair circuit driven by MDM2, MDM4 (MDMX), and mutant p53 for recruitment of MDC1 and 53BP1 on chromatin.
An Integrated Analysis of Transcriptomics and Metabolomics Elucidates the Role and Mechanism of TRPV4 in Blunt Cardiac Injury.
IRF2-driven upregulation of OAS3 promotes AML cell proliferation by modulating the JAK-STAT signaling pathway.
Bovine lactoferrin drives cell cycle arrest and alters the transcriptomic profile of NSCLC cells.
TC2N promotes the proliferation and invasion of head and neck cancer cells with the p53-R175H.
Terrestrosin D promotes autophagy and apoptosis of breast cancer cells through PSMD1-dependent activation of P53 pathway.
Curzerene suppresses epithelial-mesenchymal transition in gastric precancerous lesion cells through targeted regulation of YAP via the long non-coding RNA AFAP1-AS1.
Molecular subtyping of endometrial carcinoma cell lines uncovers subtype-specific targetable vulnerabilities.
Design, Synthesis, and Activity Evaluation of Novel Nucleosides as ADAR1 Inhibitor for the Treatment of Prostate Cancer.
Systematic pharmacology and experimental validation revealed the mechanism of Bupleurum chinense DC -mediated autophagy in alleviating osteoarthritis.
FGA, a new target of histone acetylation, inhibits apoptosis of granulosa cells in follicles.
LncRNA TMPO-AS1 facilitates cervical cancer cell tumorigenesis and ferroptosis resistance via interaction with LCN2.
Integration of scRNA-seq and bulk tissue RNA-seq data to identify cancer-associated fibroblast-related gene RGMA as a potential treatment target for esophageal cancer.
Trim65 mitigates doxorubicin-induced myocardial injury by reducing ferroptosis.
YTHDF1 promotes p53 translation and induces ferroptosis during acute cerebral ischemia/reperfusion through m(6)A-dependent binding.
A new specific GluN2B partial antagonist ameliorates brain injury caused by ischemic stroke in rats.
The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI.
CFAP100 couples microtubule glutamylation to spindle pole integrity in keratinocytes to promote epidermal development.
Extracellular vesicle-derived lncRNA VIM-AS1 promotes diabetic wound healing by promoting glycolysis and alleviating cellular senescence.
Effects of Paeoniae Radix Rubra on lowering lipid via bioinformatics and gut microbiome.
Dopamine receptor agonist pramipexole exerts neuroprotection on global cerebral ischemia/reperfusion injury by inhibiting ferroptosis.
Dynamic O-GlcNAcylation coordinates etoposide-triggered tumor cell pyroptosis by regulating p53 stability.
Unlocking the potential of LHPP: Inhibiting glioma growth and cell cycle via the MDM2/p53 pathway.
Taraxasterol regulates p53 transcriptional activity to inhibit pancreatic cancer by inducing MDM2 ubiquitination degradation.
Exosomes From Human Umbilical Cord Mesenchymal Stem Cells Alleviate Oxidative Stress-Induced POI by Regulating Autophagic Homeostasis Through the AMPK Pathway.
USP38 exacerbates myocardial injury and malignant ventricular arrhythmias after ischemia/reperfusion by promoting ferroptosis through the P53/SLC7A11 pathway.
Discovery of Novel Small-Molecule Inhibitors Disrupting the MTDH-SND1 Protein-Protein Interaction.
Comprehensive Pan-Cancer Analysis and Functional Studies Reveal SLC2A6 as a Ferroptosis Modulator in Hepatocellular carcinoma.
FN1 shapes the behavior of papillary thyroid carcinoma through alternative splicing of EDB region.
Revealing the role of cancer-associated fibroblast senescence in prognosis and immune landscape in pancreatic cancer.
Aberrant STING activation promotes macrophage senescence by suppressing autophagy in vascular aging from diabetes.
Interaction of STIL with FOXM1 regulates SF3A3 transcription in the hepatocellular carcinoma development.
RFWD2 increases proliferation and CDDP resistance of osteosarcoma cells.
Unc5b prevents macrophage-derived foam cell migration and promotes atherosclerotic development via the P53-cuproptosis signaling pathway.
Maternal exposure to deltamethrin during pregnancy and lactation impairs hippocampal learning and memory function of male offspring by ferroptosis.
Diisooctyl phthalate (DIOP) exposure leads to cell apoptosis to HUVEC cells and toxicity to Caenorhabditis elegans through increasing the oxidative stress.
Long-chain chlorinated paraffins (LCCPs) exposure induces apoptosis in primary chicken embryo hepatocytes through oxidative stress.
Investigation into the influence of mild hypothermia on regulating ferroptosis through the P53-SLC7A11/GPX4 signaling pathway in sepsis-induced acute lung injury.
Gualou Xiebai Banxia Decoction suppresses cardiomyocyte apoptosis in mice after myocardial infarction through activation of acetaldehyde dehydrogenase 2.
Naoxintong capsule accelerates mitophagy in cerebral ischemia-reperfusion injury via TP53/PINK1/PRKN pathway based on network pharmacology analysis and experimental validation.
Synergistic effects of combined lead and iprodione exposure on P53 signaling-mediated hepatotoxicity, enterotoxicity and transgenerational toxicity in zebrafish.
NEK2 Promotes ESCC Malignant Progression by Inhibiting Cellular Senescence via the FOXM1/c-Myc/p27 Signaling Pathway.
The H5N1-NS1 protein affects the host cell cycle and apoptosis through interaction with the host lncRNA PIK3CD-AS2.
Antiviral mechanism of Fuzhengjiedu San against porcine reproductive and respiratory syndrome virus.
Thiostrepton suppresses colorectal cancer progression through reactive oxygen species related endoplasmic reticulum stress.
NUC7738 Induces Apoptosis Through Modulating Stability of P53 in Esophageal Cancer Cells.
Multi-omics analysis explore the mechanism of deoxynivalenol inhibiting rabbit appetite through microbial-gut-brain axis.
Impaired degradation of PLCG1 by chaperone-mediated autophagy promotes cellular senescence and intervertebral disc degeneration.
Integrated multiomics approach and pathological analyses provide new insights into hepatic injury and metabolic alterations in Saanen goats after dietary exposure to aflatoxin B(1).
CB-MNCs@ CS/HEC/GP promote wound healing in aged murine pressure ulcer model.
Microbiota governs host chenodeoxycholic acid glucuronidation to ameliorate bile acid disorder induced diarrhea.
Hsa_circ_0125356 promotes gemcitabine resistance by modulating WNT canonical and non-canonical pathways via miR-582-5p/FGF9 axis in non-small cell lung cancer.
The inhibition of ZC3H13 attenuates G2/M arrest and apoptosis by alleviating NABP1 m6A modification in cisplatin-induced acute kidney injury.
Exploring potential targets and mechanisms of renal tissue damage caused by N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone (6-PPDQ) through network toxicology and animal experiments: A case of chronic kidney disease.
SIRT3 alleviates mitochondrial dysfunction and senescence in diabetes-associated periodontitis by deacetylating LRPPRC.
Effect of the Deubiquitinating Peptidase 7 (USP7) on Hepatitis B Virus (HBV) Replication and the Antiviral Efficacy of Entecavir (ETV).
Propofol inhibits glioma growth by blocking the formation of the NF-κB/LGI4 feedback loop to activate TP53 self-transcription.
Thermoradiotherapy reverses proliferation, metastasis, and anoikis resistance in glioblastoma through ITGA5-PI3K/AKT axis.
Fluorescence lifetime clocks quantify senescence and aging.
Canagliflozin ameliorates high-salt-induced renal injury and premature aging in male Dahl salt-sensitive rats, with associated changes in SIRT6/HIF-1α signaling.
Inhibition of matrix metalloproteinase-9 attenuates kidney fibrosis and cellular senescence in the transition from acute kidney injury to chronic kidney disease.
ABI3BP deficiency alleviates Ang II-induced VSMC senescence through the Nrf2 signalling pathway.
ALFA nanobody-guided endogenous labeling.
Nanovaccine loaded with seno-antigen target senescent cells to improve metabolic disorders of adipose tissue and cardiac dysfunction.
Evaluation of anti-tumor activity of borated camptothecin derivatives targeting topoisomerase 1 against hepatocellular carcinoma and intrahepatic cholangiocarcinoma.
5'tiRNA-Glu-TTC targets TRPV3 and activates the PI3K/AKT signaling pathway to modulate skin photoaging.
Association of TP53 and EZH2 with salivary adenoid cystic carcinoma.
Lactylation-driven KRT19 promotes non-small cell lung cancer progression by suppressing cellular senescence.
Echinacoside as a Novel Ferroptosis Inducer in Hepatocellular Carcinoma: Mechanistic Insights from TP53/SLC7A11/GPX4 Pathway Modulation.
Identification and functional characterization of genes associated with lipopolysaccharide in lung adenocarcinoma.
Kaempferol inhibits atherosclerotic plaque development via dual-targeting of p53-p21-p16 senescence pathway and Nrf2/HO-1/NQO1 antioxidant mechanism: Insights from combined in vivo and in vitro research.
TRIM47-facilitated PLK1 stabilization promotes the proliferation of liver cancer cells.
EXOSC3 knockdown induces G1/S phase arrest to suppress hepatocellular carcinoma cell proliferation.
The Ku80-p53-SIRT1 axis in DNA damage response contributes to sporadic and familial ALS and FTD.
Nicotinamide riboside alleviates sepsis-induced acute kidney injury by suppressing ferroptosis.
Protocol for developing a mouse model of gastric cancer following Helicobacter pylori eradication and chronic ethanol feeding.
The SARS-CoV-2 nucleocapsid protein induces microglia senescence-mediated cognitive impairment via Glycolysis.
LAX1 as a core biomarker in Alzheimer's disease and periodontitis via the STAT signaling pathway.
NSUN2 Negatively Regulates TP53 mRNA Stability to Promote the Malignant Progression of Nasopharyngeal Carcinoma.
Biodentine Counteracts the Aging Process of Human Dental Pulp Stem Cells Through Wnt/β-Catenin Pathway.
Extracellular vesicle-mediated delivery of circp53 suppresses the progression of multiple cancers by activating the CypD/TRAP/HSP90 pathway.
Benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE) Induces Ferroptosis in Rat Cortical Neurons via p53-SLC7A11-ALOX12/p53-SAT1-ALOX15 Pathways.
Synergistic effects of the curcumin analog HO-3867 and olaparib in transforming fallopian tube epithelial cells.
IFI16 Induced by p53 Activates the NF-κB Pathway to Counteract Cisplatin-Induced Apoptosis in Cervical Cancer Cells.
Role of UVA-driven cellular senescence via mTOR activation in dihydrotestosterone-induced hair loss in androgenetic alopecia mouse model.
Single-Cell RNA-Seq Reveals Aging-Related Impairment of Microglial Efferocytosis Contributing to Apoptotic Cells Accumulation After Retinal Injury.
Mechanism of sulforaphane in treatment of pancreatic cancer cell based on network pharmacology and in vitro experiments.
The n-butanol extract of Polygonatum sibiricum improves spleen aging via p53 pathway.
Targeting to Intensify M2 Macrophage Polarization Ameliorate Podocyte Lipid Accumulation and Damage by Tea Polyphenols via Activating SIRT1 in the Aged Model Rats With DKD.
Lobaric Acid Exhibits Anticancer Potential by Modulating the Wnt/β-Catenin Signaling Pathway in MCF-7 Cells.
LIMK1 as a Novel Kinase of β-Catenin Promotes Esophageal Cancer Metastasis by Cooperating With CDK5.
E2F1-autophagy-ALDH1A1 axis enhances self-renewal and drug resistance of lung cancer stem-like cells in a p53-dependent manner.
Erchen decoction alleviates silicosis by attenuating ferroptosis and fibrosis in alveolar macrophages via modulating the P53/HMOX1 pathway.
The long noncoding RNA lnc-FANCI-2 intrinsically restricts RAS signaling in human papillomavirus type 16-infected cervical cancer cells.
Reduction of lymphotoxin beta receptor induces cellular senescence via the MDMX-p53 pathway.
Senescent fibroblasts secrete CTHRC1 to promote cancer stemness in hepatocellular carcinoma.
Advanced glycation end products induce inflammaging in periodontal ligament fibroblasts through RAGE/AKT/mTOR/glycolysis pathway.
m6A-modified circZNF548 regulates exosomal miR-7108-3p to activate CD3(+)CD8(+) T cells and suppress NSCLC growth by JMY.
Synthesis of USP5-IN-1 derivatives as novel USP5 inhibitors with potent activity against cholangiocarcinoma cells.
MLCK inhibition induces synthetic lethality in MYC-driven cancer.
Fut8 regulated Unc5b hyperfucosylation reduces macrophage emigration and accelerates atherosclerosis development via the ferroptosis pathway.
Hepatocyte-Enriched miRNA-193b-3p Promotes Hepatitis B Virus Replication by Dual Activation of Viral Core Promoter Activity and Autophagy Induction by Targeting IGF-1R.
The role of HM13 expression and its relationship to PI3K/Akt and p53 signaling pathways in colorectal cancer.
MIER2/PGC1A elicits sunitinib resistance via lipid metabolism in renal cell carcinoma.
Integrative analysis of genetic variability and functional traits in lung adenocarcinoma epithelial cells via single-cell RNA sequencing, GWAS, bayesian deconvolution, and machine learning.
Elevated CD47 Expression Impairs Elimination of Photoaged Fibroblasts by Macrophages and Serves as a Potential Biomarker for Photoaging.
MDM1 overexpression promotes p53 expression and cell apoptosis to enhance therapeutic sensitivity to chemoradiotherapy in patients with colorectal cancer.
Investigation of c-Fos/c-Jun Signaling Pathways in Periostracum Cicadae's Inhibition of EMT in Gastric Tissue.
Surfactant protein D alleviates chondrocytes senescence by upregulating SIRT3/SOD2 pathway in osteoarthritis.
Thesium chinense Turcz. and its compound astragalin alleviate lipopolysaccharide-induced acute lung injury via the PI3K/AKT/p53 signaling pathway.
Development of Novel PRMT7 Inhibitors for the Treatment of Prostate Cancer.
Lactate shuttling links histone lactylation to adult hippocampal neurogenesis in mice.
Emodin alleviates the damage to lens epithelial cells in diabetic cataract by repressing the p53-mediated ferroptosis pathway.
GAMT facilitates tumor progression via inhibiting p53 in clear cell renal cell carcinoma.
Blocking triggering receptors expressed on myeloid cell-1 alleviates alveolar epithelial cell senescence by inhibiting oxidative stress in pulmonary fibrosis.
Artemisinin regulates cell proliferation, apoptosis, and the inflammatory response of human dental pulp stem cells through the p53 signaling pathway under LPS-induced inflammation.
Aging and autophagic phenotypic changes in bone marrow mesenchymal stem cells in glucocorticoid-induced osteonecrosis.
Cold atmospheric plasma drives USP49/HDAC3 axis mediated ferroptosis as a novel therapeutic strategy in endometrial cancer via reinforcing lactylation dependent p53 expression.
Dehydrocorydaline attenuates bleomycin-induced pulmonary fibrosis by inhibiting fibroblast activation.
Therapeutic Targets and Natural Product Screening for Cognitive Impairments Associated with Ferroptosis in Wilson's Disease.
Ginsenoside Rg2 Attenuates Aging-Induced Liver Injury via Inhibiting Caspase 8-Mediated Pyroptosis, Apoptosis and Modulating Gut Microbiota.
Cadmium-induced annulus fibrosus cell senescence contributes to intervertebral disc degeneration via the JNK/p53 signaling pathway.
Comprehensive analysis and validation reveal DEPDC1 as a potential diagnostic biomarker associated with tumor immunity in non-small-cell lung cancer.
Significant role and the underly mechanism of cullin-1 in chronic obstructive pulmonary disease.
Integrated Network Pharmacology and in vivo Experimental Validation Approach to Explore the Potential Antioxidant Effects of Annao Pingchong Decoction in Intracerebral Hemorrhage Rats.
Oncoproteins E6 and E7 upregulate topoisomerase I to activate the cGAS-PD-L1 pathway in cervical cancer development.
IDO1-mediated kynurenine production inhibits IGFBP5 signaling to promote 5-fluorouracil-induced senescence escape and chemoresistance in colorectal cancer.
The mitochondria‒paraspeckle axis regulates the survival of transplanted stem cells under oxidative stress conditions.
EMF treatment delays mesenchymal stem cells senescence during long-term in vitro expansion by modulating autophagy.
Urolithin A alleviates cell senescence by inhibiting ferroptosis and enhances corneal epithelial wound healing.
Reduced dynamicity and increased high-order protein assemblies in dense fibrillar component of the nucleolus under cellular senescence.
Ubiquitination of p21 by E3 ligase RNF135 promotes the proliferation of human glioblastoma cells.
Beyond ribosomal function: RPS6 deficiency suppresses cholangiocarcinoma cell growth by disrupting alternative splicing.
Daphnetin induces ferroptosis in ovarian cancer by inhibiting NAD(P)H:Quinone oxidoreductase 1 (NQO1).
Catalpol alleviates heat stroke-induced liver injury in mice by downregulating the JAK/STAT signaling pathway.
Integrative analysis of the transcriptome and metabolome reveals the importance of hepatokine FGF21 in liver aging.
Aspirin exposure coupled with hypoxia interferes energy metabolism, antioxidant and autophagic processes and causes liver injury in estuarine goby Mugilogobius chulae.
YIPF2 regulates genome integrity.
Deferoxamine alleviates chondrocyte senescence and osteoarthritis progression by maintaining iron homeostasis.
Gliomedin drives gastric cancer cell proliferation and migration, correlating with a poor prognosis.
Deletion of ASPP1 in myofibroblasts alleviates myocardial fibrosis by reducing p53 degradation.
Baicalin Ameliorates Depression-like Behaviors via Inhibiting Neuroinflammation and Apoptosis in Mice.
Porphyromonas gingivalis virulence factors induce toxic effects in SH-SY5Y neuroblastoma cells: GRK5 modulation as a protective strategy.
Novel potent molecular glue degraders against broad range of hematological cancer cell lines via multiple neosubstrates degradation.
TRIM16 mitigates impaired osteogenic differentiation and antioxidant response in D-galactose-induced senescent osteoblasts.
Promotion of endoplasmic reticulum retrotranslocation by overexpression of E3 ubiquitin-protein ligase synoviolin 1 reduces endoplasmic reticulum stress and preserves cone photoreceptors in cyclic nucleotide-gated channel deficiency.
Da-Chai-Hu-Tang Formula inhibits the progression and metastasis in HepG2 cells through modulation of the PI3K/AKT/STAT3-induced cell cycle arrest and apoptosis.
Chitosan-Modified AgNPs Efficiently Inhibit Swine Coronavirus-Induced Host Cell Infections via Targeting the Spike Protein.
Design and Synthesis of 7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic Acid Derivatives as PP5 Inhibitors To Reverse Temozolomide Resistance in Glioblastoma Multiforme.
Gastrodin Alleviates Angiotensin II-Induced Hypertension and Myocardial Apoptosis via Inhibition of the PRDX2/p53 Pathway In Vivo and In Vitro.
Krüppel-like transcription factor 14 alleviates alveolar epithelial cell senescence by inhibiting endoplasmic reticulum stress in pulmonaryfibrosis.
FABP4 deficiency ameliorates alcoholic steatohepatitis in mice via inhibition of p53 signaling pathway.
The Long Non-Coding RNA NR3C2-8:1 Promotes p53-Mediated Apoptosis through the miR-129-5p/USP10 Axis in Amyotrophic Lateral Sclerosis.
Dual targeting of wild-type p53 and gut microbiota by Magnolol represses key metabolic process and kills CRC cells.
EtROP38 suppresses apoptosis of host cells infected with Eimeria tenella by inhibition of the p38MAPK pathway.
The lncRNA TPTEP1 suppresses PI3K/AKT signalling and inhibits ovarian cancer progression by interacting with PTBP1.
LTF ameliorates cartilage endplate degeneration by suppressing calcification, senescence and matrix degradation through the JAK2/STAT3 pathway.
Plasma-derived exosome miR-10a-5p promotes premature ovarian failure by target BDNF via the TrkB/Akt/mTOR signaling pathway.
Exosomes Derived from Rejuvenated Stem Cells Inactivate NLRP3 Inflammasome and Pyroptosis of Nucleus Pulposus Cells via the Transfer of Antioxidants.
Seno-antigen-pulsed dendritic cell vaccine induce anti-aging immunity to improve adipose tissue senescence and metabolic abnormalities.
NAT10 inhibition promotes ac4C-dependent ferroptosis to counteract sorafenib resistance in nasopharyngeal carcinoma.
Siwu decoction exerts a phytoestrogenic osteoprotective effect on postmenopausal osteoporosis via the estrogen receptor/phosphatidylinositol 3-kinase/serine/threonine protein kinase pathway.
Human adipose and umbilical cord mesenchymal stem cell-derived extracellular vesicles mitigate photoaging via TIMP1/Notch1.
Sensing of endogenous retroviruses-derived RNA by ZBP1 triggers PANoptosis in DNA damage and contributes to toxic side effects of chemotherapy.
HIV Protein Nef Induces Cardiomyopathy Through Induction of Bcl2 and p21.
Bifidobacterium lactis-Derived Vesicles Attenuate Hippocampal Neuroinflammation by Targeting IL-33 to Regulate FoxO6/P53 Signaling.
A TBK1-independent primordial function of STING in lysosomal biogenesis.
Genome-wide RNA-Seq identifies TP53-mediated embryonic stem cells inhibiting tumor invasion and metastasis.
IFN-γ induces acute graft-versus-host disease by promoting HMGB1-mediated nuclear-to-cytoplasm translocation and autophagic degradation of p53.
TDP-43 ameliorates aging-related cartilage degradation through preventing chondrocyte senescence.
Transcriptomics reveals the mechanism of terbuthylazine-induced nephrotoxicity in chickens: Insights from AMPK/p53-mediated apoptosis perspective.
Buparlisib and ponatinib inhibit aggressiveness of cholangiocarcinoma cells via suppression of IRS1-related pathway by targeting oxidative stress resistance.
Cannabidiol suppresses proliferation and induces cell death, autophagy and senescence in human cholangiocarcinoma cells via the PI3K/AKT/mTOR pathway.
Dual-targeted halofuginone hydrobromide nanocomplexes for promotion of macrophage repolarization and apoptosis of rheumatoid arthritis fibroblast-like synoviocytes in adjuvant-induced arthritis in rats.
SNPs Give LACTB Oncogene-Like Functions and Prompt Tumor Progression via Dual-Regulating p53.
ZNF652 exerts a tumor suppressor role in lung cancer by transcriptionally downregulating cyclin D3.
Antisenescence Expansion of Mesenchymal Stem Cells Using Piezoelectric β-Poly(vinylidene fluoride) Film-Based Culture.
β-Hydroxybutyrate alleviates brain aging through the MTA1 pathway in D-galactose injured mice.
Design of Murine Double Minute 2 Proteolysis Targeting Chimera Degraders with a Built-In Tumor-Targeting Ability.
FXR deficiency induced ferroptosis via modulation of the CBP-dependent p53 acetylation to suppress breast cancer growth and metastasis.
p53 suppresses the inflammatory response following respiratory syncytial virus infection by inhibiting TLR2.
LRP8 promotes tumorigenesis in ovarian cancer through inhibiting p53 signaling.
Melatonin attenuates dental pulp stem cells senescence due to vitro expansion via inhibiting MMP3.
Icariin‑curcumol promotes ferroptosis in prostate cancer cells through Nrf2/HO‑1 signaling.
Glucose-modified BSA/procyanidin C1 NPs penetrate the blood-brain barrier and alleviate neuroinflammation in Alzheimer's disease models.
METTL14 affects UVB-induced human dermal fibroblasts photoaging via miR-100-3p biogenesis in an m(6)A-dependent manner.
Alkenyl oxindole is a novel PROTAC moiety that recruits the CRL4DCAF11 E3 ubiquitin ligase complex for targeted protein degradation.
Aspirin-Mediated Acetylation of SIRT1 Maintains Intestinal Immune Homeostasis.
HPV oncogenes expressed from only one of multiple integrated HPV DNA copies drive clonal cell expansion in cervical cancer.
ABI3BP promotes renal aging through Klotho-mediated ferroptosis.
Salvianolic acid A alleviates H(2)O(2)-induced endothelial oxidative injury via miR-204-5p.
Matrix stiffening promotes chondrocyte senescence and the osteoarthritis development through downregulating HDAC3.
The activation of LBH-CRYAB signaling promotes cardiac protection against I/R injury by inhibiting apoptosis and ferroptosis.
Puerarin Delays Mammary Gland Aging by Regulating Gut Microbiota and Inhibiting the p38MAPK Signaling Pathway.
The Hippo pathway terminal effector TAZ/WWTR1 mediates oxaliplatin sensitivity in p53 proficient colon cancer cells.
An Ex Vivo Aorta Culture Model to Study Vascular Cellular Senescence.
T-2 toxin induces mitochondrial dysfunction in chondrocytes via the p53-cyclophilin D pathway.
Metformin alleviates junctional epithelium senescence via the AMPK/SIRT1/autophagy pathway in periodontitis induced by hyperglycemia.
Curculigoside Attenuates Endoplasmic Reticulum Stress-Induced Epithelial Cell and Fibroblast Senescence by Regulating the SIRT1-P300 Signaling Pathway.
Urocortin-1 promotes colorectal cancer cell migration and proliferation and inhibits apoptosis via inhibition of the p53 signaling pathway.
PELI1: key players in the oncogenic characteristics of pancreatic Cancer.
Enhancing precision medicine: a nomogram for predicting platinum resistance in epithelial ovarian cancer.
CircFOXO3 mediates hypoxia-induced autophagy of endometrial stromal cells in endometriosis.
The mitochondrial UPR induced by ATF5 attenuates intervertebral disc degeneration via cooperating with mitophagy.
p53-dependent HIF-1α /autophagy mediated glycolysis to support Cr(VI)-induced cell growth and cell migration.
VD(3)/VDR attenuates bisphenol A-induced impairment in mouse Leydig cells via regulation of autophagy.
Photodynamic therapy inhibits cancer progression and induces ferroptosis and apoptosis by targeting P53/GPX4/SLC7A11 signaling pathways in cholangiocarcinoma.
Gut microbiota regulates the ALK5/NOX1 axis by altering glutamine metabolism to inhibit ferroptosis of intrahepatic cholangiocarcinoma cells.
LC-MS based metabonomics study on protective mechanism of ESWW in cerebral ischemia via CYTC/Apaf-1/NDRG4 pathway.
Periplcymarin targets glycolysis and mitochondrial oxidative phosphorylation of esophageal squamous cell carcinoma: Implication in anti-cancer therapy.
MaiJiTong granule attenuates atherosclerosis by reducing ferroptosis via activating STAT6-mediated inhibition of DMT1 and SOCS1/p53 pathways in LDLR(-/-) mice.
Chlormequat Chloride Inhibits TM3 Leydig Cell Growth via Ferroptosis-Initiated Inflammation.
Oncogenic HPV-induced high expression of ESM1 predicts poor prognosis and regulates aerobic glycolysis in cervical cancer.
Loss of the lysosomal protein CLN3 modifies the lipid content of the nuclear envelope leading to DNA damage and activation of YAP1 pro-apoptotic signaling.
Potential Molecular Mechanism of Illicium simonsii Maxim Petroleum Ether Fraction in the Treatment of Hepatocellular Carcinoma.
Integrative single-cell and bulk transcriptomes analyses reveals heterogeneity of serine-glycine-one-carbon metabolism with distinct prognoses and therapeutic vulnerabilities in HNSCC.
Design, synthesis and biological evaluation of indoline-maleimide conjugates as potential antitumor agents for the treatment of colorectal cancer.
CSPG4P12 polymorphism served as a susceptibility marker for esophageal cancer in Chinese population.
Hyperactivation of SREBP induces pannexin-1-dependent lytic cell death.
TBK1 pharmacological inhibition mitigates osteoarthritis through attenuating inflammation and cellular senescence in chondrocytes.
Distinguishing high-metastasis-potential circulating tumor cells through fluidic shear stress in a bloodstream-like microfluidic circulatory system.
RNF31 alleviates liver steatosis by promoting p53/BNIP3-related mitophagy in hepatocytes.
MCM8 promotes gastric cancer progression through RPS15A and predicts poor prognosis.
Formosanin C inhibits pulmonary metastasis by targeting stearyl CoA desaturase-1.
Celastrol mediates CAV1 to attenuate pro-tumorigenic effects of senescent cells.
Peptide PDRPS6 attenuates myocardial ischemia injury by improving mitochondrial function.
Intragland Expression of the Shh Gene Alleviates Irradiation-Induced Salivary Gland Injury through Microvessel Protection and the Regulation of Oxidative Stress.
Overexpression of transcription factor TBX5 inhibits the activation of YAP1-TEAD1 pathway to promote ferroptosis in lung cancer cells.
Flexible Sono-Piezo Patch for Functional Sweat Gland Repair through Endogenous Microenvironmental Remodeling.
m6A-Mediated IRS1 Regulates the Development of Oral Squamous Cell Carcinoma through p53/Line-1 Signaling.
Alphaherpesvirus manipulates retinoic acid metabolism for optimal replication.
Circular RNA CircVmn2r1 Acts as a miR-223-3p Sponge to Promote Kidney Aging by Regulating NLRP3 Expression in Mice.
Graphene oxide quantum dots-loaded sinomenine hydrochloride nanocomplexes for effective treatment of rheumatoid arthritis via inducing macrophage repolarization and arresting abnormal proliferation of fibroblast-like synoviocytes.
TCF12 regulates the TGF-β/Smad2/3 signaling pathway to accelerate the progression of osteoarthritis by targeting CXCR4.
Regulated secretion of mutant p53 negatively affects T lymphocytes in the tumor microenvironment.
MicroRNA-10a-5p-mediated downregulation of GATA6 inhibits tumor progression in ovarian cancer.
FAXDC2 inhibits the proliferation and invasion of human liver cancer HepG2 cells.
pH-driven preparation of pea protein isolate-curcumin nanoparticles effectively enhances antitumor activity.
Hydrogen sulfide inhibits alveolar type II cell senescence and limits pulmonary fibrosis via promoting MDM2-mediated p53 degradation.
Carfilzomib suppressed LDHA-mediated metabolic reprogramming by targeting ATF3 in esophageal squamous cell carcinoma.
PKD knockdown mitigates Ang II-induced cardiac hypertrophy and ferroptosis via the JNK/P53 signaling pathway.
Rapamycin protects mouse skin from ultraviolet B-induced photodamage by modulating Hspb2-mediated autophagy and apoptosis.
A CANCER PERSISTENT DNA REPAIR CIRCUIT DRIVEN BY MDM2, MDM4 (MDMX), AND MUTANT P53 FOR RECRUITMENT OF MDC1 AND 53BP1 TO CHROMATIN.
Resveratrol protected against the development of endometriosis by promoting ferroptosis through miR-21-3p/p53/SLC7A11 signaling pathway.
17β-Estradiol inhibits hydrogen peroxide-induced senescence and apoptosis in human umbilical vein endothelial cells by regulating the THBS1/TGF-β/Smad axis.
Traditional Chinese Medicine formula Wubi Shanyao Pills protects against reproductive aging by activating SIRT1/3 to reduce apoptosis.
MitomiR-1736-3p regulates copper-induced mitochondrial pathway apoptosis by inhibiting AATF in chicken hepatocytes.
DEPDC1B enhances malignant phenotypes of multiple myeloma through upregulating CCNB1 and inhibiting p53 signaling pathway.
USP14 promotes the proliferation of cervical cancer via upregulating β-catenin.
The dual role of the DREAM/G2M pathway in non-tumorigenic immortalization of senescent cells.
Ginsenoside Rg5 inhibits lipid accumulation and hepatocyte apoptosis via the Notch1 signaling pathway in NASH mice.
Inhibition of miR-143-3p Restores Blood-Testis Barrier Function and Ameliorates Sertoli Cell Senescence.
Discovery of Novel Antitumor Small-Molecule Agent with Dual Action of CDK2/p-RB and MDM2/p53.
Resveratrol-laden mesoporous silica nanoparticles regulate the autophagy and apoptosis via ROS-mediated p38-MAPK/HIF-1a /p53 signaling in hypertrophic scar fibroblasts.
Integrin α(4) Positive Subpopulation in Adipose Derived Stem Cells Effectively Reduces Infarct Size through Enhanced Engraftment into Myocardial Infarction.
SYNJ2BP ameliorates intervertebral disc degeneration by facilitating mitochondria-associated endoplasmic reticulum membrane formation and mitochondrial Zn(2+) homeostasis.
Discovery of potent thiazolidin-4-one sulfone derivatives for inhibition of proliferation of osteosarcoma in vitro and in vivo.
Hyperactivation of p53 contributes to mitotic catastrophe in podocytes through regulation of the Wee1/CDK1/cyclin B1 axis.
Macrophage polarization and macrophage-related factor expression in hypertrophy of the ligamentum flavum.
Self-healing hydrogels loaded with Spatholobi Caulis alleviate disc degeneration by promoting autophagy in nucelus pulposus.
The anti-tumor efficacy of a recombinant oncolytic herpes simplex virus mediated CRISPR/Cas9 delivery targeting in HPV16-positive cervical cancer.
To explore the protective mechanism of promethazine against hippocampal neuron injury based on network pharmacology and experimental verification.
Cyberpharmacology uncover the mechanism of the total Rhizoma Coptidis extracts ameliorate chronic atrophic gastritis.
The RIG-I-like receptor signaling pathway triggered by Staphylococcus aureus promotes breast cancer metastasis.
Inhibition of miR-9-3p facilitates ferroptosis by activating SAT1/p53 pathway in lung adenocarcinoma.
Synthesis, anticancer and antibacterial evaluation of novel spiramycin-acylated derivatives.
Ku70 silencing aggravates oxygen-glucose deprivation/reperfusion-induced injury by activation of the p53 apoptotic pathway in rat cortical astrocytes.
Taurine rescues intervertebral disc degeneration by activating mitophagy through the PINK1/Parkin pathway.
Machine learning-based prognostic model of lactylation-related genes for predicting prognosis and immune infiltration in patients with lung adenocarcinoma.
The vitamin D receptor is essential for the replication of pseudorabies virus.
Novel lncRNA 803 related to Marek's disease inhibits apoptosis of DF-1 cells.
Can thymosin beta 10 function both as a non-invasive biomarker and chemotherapeutic target in human colorectal cancer?
Baicalin protects against hepatocyte injury caused by aflatoxin B(1) via the TP53-related ferroptosis Pathway.
PLCγ1 deficiency in chondrocytes accelerates the age-related changes in articular cartilage and subchondral bone.
Tetrastigma hemsleyanum polysaccharide combined with doxorubicin promote ferroptosis and immune function in triple-negative breast cancer.
Zwitterion-Lubricated Hydrogel Microspheres Encapsulated with Metformin Ameliorate Age-Associated Osteoarthritis.
The Loss of an Orphan Nuclear Receptor NR2E3 Augments Wnt/β-catenin Signaling via Epigenetic Dysregulation that Enhances Sp1-β catenin-p300 Interactions in Hepatocellular Carcinoma.
Antitumorigenic potential of Lactobacillus-derived extracellular vesicles: p53 succinylation and glycolytic reprogramming in intestinal epithelial cells via SIRT5 modulation.
Electroacupuncture facilitates vascular normalization by inhibiting Glyoxalase1 in endothelial cells to attenuate glycolysis and angiogenesis in triple-negative breast cancer.
Annexin A1 binds PDZ and LIM domain 7 to inhibit adipogenesis and prevent obesity.
Design, Synthesis, and Evaluation of p53Y220C Acetylation Targeting Chimeras (AceTACs).
Agroprospecting of Biowastes: Globe Artichoke (Cynara scolymus L. Cultivar Tema, Asteraceae) as Potential Source of Bioactive Compounds.
Two-polarized roles of transcription factor FOSB in lung cancer progression and prognosis: dependent on p53 status.
METTL3 Promotes Nucleus Pulposus Cell Senescence in Intervertebral Disc Degeneration by Regulating TLR2 m6A Methylation and Gut Microbiota.
Pt(iv) derivatives of cisplatin and oxaliplatin bearing an EMT-related TMEM16A/COX-2-selective dual inhibitor against colorectal cancer cells HCT116.
Liraglutide Protects Pancreatic Islet From Ischemic Injury by Reducing Oxidative Stress and Activating Akt Signaling During Cold Preservation to Improve Islet Transplantation Outcomes.
FTO ameliorates doxorubicin-induced cardiotoxicity by inhibiting ferroptosis via P53-P21/Nrf2 activation in a HuR-dependent m6A manner.
Breast cancer cells have an increased ferroptosis risk induced by system x(c)(-) blockade after deliberately downregulating CYTL1 to mediate malignancy.
Pyrogallol promotes growth arrest by activating the p53-mediated up-regulation of p21 and p62/SQSTM1-dependent degradation of β-catenin in nonsmall cell lung cancer cells.
Fusobacterium nucleatum triggers senescence phenotype in gingival epithelial cells.
Excess iron accumulation mediated senescence in diabetic kidney injury.
Integrating Network Pharmacology and Experimental Validation to Reveal the Mechanism of Vine Grape Tea Polyphenols on Hyperuricemia-Induced Renal Injury in Mice.
Excessive processing and acetylation of OPA1 aggravate age-related hearing loss via the dysregulation of mitochondrial dynamics.
p53 accelerates endothelial cell senescence in diabetic retinopathy by enhancing FoxO3a ubiquitylation and degradation via UBE2L6.
The function of Bazhen decoction in rescuing progeroid cell senescence via facilitating G-quadruplex resolving and telomere elongation.
Expression of Multicopy Tandem Recombinant Ginseng Hexapeptide in Bacillus subtilis and the Evaluation of Antiaging Activity.
DEC1 is involved in circadian rhythm disruption-exacerbated pulmonary fibrosis.
Diphthamide deficiency promotes association of eEF2 with p53 to induce p21 expression and neural crest defects.
A programmable targeted protein-degradation platform for versatile applications in mammalian cells and mice.
Discovery of ganoderic acid A (GAA) PROTACs as MDM2 protein degraders for the treatment of breast cancer.
Single-cell and Spatial Transcriptomics Identified Fatty Acid-binding Proteins Controlling Endothelial Glycolytic and Arterial Programming in Pulmonary Hypertension.
GRAS1 non-coding RNA protects against DNA damage and cell death by binding and stabilizing NKAP.
A chemo/chemodynamic nanoparticle based on hyaluronic acid induces ferroptosis and apoptosis for triple-negative breast cancer therapy.
A Novel Myricetin Derivative with Anti-cancer Properties Induces Cell Cycle Arrest and Apoptosis in A549 Cells.
Hypoxia-induced long non-coding RNA LINC00460 promotes p53 mediated proliferation and metastasis of pancreatic cancer by regulating the miR-4689/UBE2V1 axis and sequestering USP10.
Crosstalk between PML and p53 in response to TGF-β1: A new mechanism of cardiac fibroblast activation.
Direct targeting of sEH with alisol B alleviated the apoptosis, inflammation, and oxidative stress in cisplatin-induced acute kidney injury.
Differential effects of WRAP53 transcript variants on non-small cell lung cancer cell behaviors.
Sarcoma protein kinase inhibition alleviates liver fibrosis by promoting hepatic stellate cells ferroptosis.
Integrating Network Pharmacology and Experimental Validation to Explore the Pharmacological Mechanism of Astragaloside IV in Treating Bleomycin-Induced Pulmonary Fibrosis.
Esomeprazole Alleviates Cisplatin Resistance by Inhibiting the AKT/mTOR Pathway in Ovarian Cancer Cells.
DNAJC8: a prognostic marker and potential therapeutic target for hepatocellular carcinoma.
Simultaneous suppression of PKM2 and PHGDH elicits synergistic anti-cancer effect in NSCLC.
Reactivation of mutant p53 in esophageal squamous cell carcinoma by isothiocyanate inhibits tumor growth.
NPM1 promotes nasopharyngeal carcinoma metastasis and stemness by recruiting Mdm2 to induce the ubiquitination-mediated degradation of p53.
miR-186-ANXA9 signaling inhibits tumorigenesis in breast cancer.
ZNF655 promotes the progression of hepatocellular carcinoma through PSMB8.
Bazi Bushen alleviates skin senescence by orchestrating skin homeostasis in SAMP6 mice.
Aerobic exercise enhances mitochondrial homeostasis to counteract D-galactose-induced sarcopenia in zebrafish.
miR-656-3p inhibits melanomas in vitro and in vivo by inducing senescence via inhibiting LMNB2.
Apatinib combined with olaparib induces ferroptosis via a p53-dependent manner in ovarian cancer.
Novel flavonoid 1,3,4-oxadiazole derivatives ameliorate MPTP-induced Parkinson's disease via Nrf2/NF-κB signaling pathway.
Characterization of a Human Gastrointestinal Stromal Tumor Cell Line Established by SV40LT-Mediated Immortalization.
miR-491-5p regulates the susceptibility of glioblastoma to ferroptosis through TP53.
Nephroprotective Effects of Cardamonin on Renal Ischemia Reperfusion Injury/UUO-Induced Renal Fibrosis.
Serum response factor activates peroxidasin transcription to block senescence of hepatic stellate cells.
Pregnane X receptor activation alleviates renal fibrosis in mice via interacting with p53 and inhibiting the Wnt7a/β-catenin signaling.
Electroacupuncture inhibits hippocampal neuronal apoptosis and improves cognitive dysfunction in mice with vascular dementia via the JNK signaling pathway.
Polystyrene nanoplastics induce haematotoxicity with cell oxeiptosis and senescence involved in C57BL/6J mice.
Improved anti-tumor activity of fluorinated camptothecin derivatives 9-fluorocamptothecin and 7-ethyl-9-fluorocamptothecin on hepatocellular carcinoma by targeting topoisomerase I.
Acid-base homeostasis orchestrated by NHE1 defines the pancreatic stellate cell phenotype in pancreatic cancer.
URI alleviates tyrosine kinase inhibitors-induced ferroptosis by reprogramming lipid metabolism in p53 wild-type liver cancers.
Tong Sai granule improves AECOPD via regulation of MAPK-SIRT1-NF-κB pathway and cellular senescence alleviation.
Effect of Ferulago lutea (Poir.) Grande Essential Oil on Molecular Hallmarks of Skin Aging.
Depletion of PIEZO1 expression is accompanied by upregulating p53 signaling in mice with perioperative neurocognitive disorder.
Precise genome editing of the Kozak sequence enables bidirectional and quantitative modulation of protein translation to anticipated levels without affecting transcription.
Clearance of Stress-Induced Premature Senescent Cells Alleviates the Formation of Abdominal Aortic Aneurysms.
Melatonin alleviates oxidative stress-induced injury to nucleus pulposus-derived mesenchymal stem cells through activating PI3K/Akt pathway.
USP51 facilitates colorectal cancer stemness and chemoresistance by forming a positive feed-forward loop with HIF1A.
RBM25 regulates hypoxic cardiomyocyte apoptosis through CHOP-associated endoplasmic reticulum stress.
A Responsive Nanorobot Modulates Intracellular Zinc Homeostasis to Amplify Mitochondria-Targeted Phototherapy.
Hydrogen sulfide inhibits the rupture of fetal membranes throngh anti-aging pathways.
Cmpk2 regulates mitochondrial function in glucocorticoid-induced osteoblast senescence and affects glucocorticoid-inhibited osteoblast differentiation.
Bazi Bushen maintains intestinal homeostasis through inhibiting TLR4/NFκB signaling pathway and regulating gut microbiota in SAMP6 mice.
Activation of the p53 signaling pathway by piRNA-MW557525 overexpression induces a G0/G1 phase arrest thus inhibiting neuroblastoma growth.
Extracellular vesicle-derived silk fibroin nanoparticles loaded with MFGE8 accelerate skin ulcer healing by targeting the vascular endothelial cells.
IGF2 deficiency promotes liver aging through mitochondrial dysfunction and upregulated CEBPB signaling in D-galactose-induced aging mice.
PDK4 rescues high-glucose-induced senescent fibroblasts and promotes diabetic wound healing through enhancing glycolysis and regulating YAP and JNK pathway.
Role of DCLK1/Hippo pathway in type II alveolar epithelial cells differentiation in acute respiratory distress syndrome.
BSHXF-medicated serum combined with ADSCs regulates the TGF-β1/Smad pathway to repair oxidatively damaged NPCs and its component analysis.
Biallelic Dicer1 Mutations in the Gynecologic Tract of Mice Drive Lineage-Specific Development of DICER1 Syndrome-Associated Cancer.
Hydrogen sulfide ameliorates endothelial dysfunction in aging arteries by regulating ferroptosis.
Naringin against doxorubicin-induced hepatotoxicity in mice through reducing oxidative stress, inflammation, and apoptosis via the up-regulation of SIRT1.
Klotho protects against aged myocardial cells by attenuating ferroptosis.
LncRNA H19 mediates BMP9-induced angiogenesis in mesenchymal stem cells by promoting the p53-Notch1 angiogenic signaling axis.
Anticancer efficacy of hirsuteine against colorectal cancer by opposite modulation of wild-type and mutant p53.
CX3CR1(hi) macrophages sustain metabolic adaptation by relieving adipose-derived stem cell senescence in visceral adipose tissue.
Impairment of rigidity sensing caused by mutant TP53 gain of function in osteosarcoma.
RSL1D1 knockdown induces ferroptosis and mediates ferrous iron accumulation in senescent cells by inhibiting FTH1 mRNA stability.
Adiponectin Attenuates Splenectomy-Induced Cognitive Deficits by Neuroinflammation and Oxidative Stress via TLR4/MyD88/NF-κb Signaling Pathway in Aged Rats.
LMNB1 deletion in ovarian cancer inhibits the proliferation and metastasis of tumor cells through PI3K/Akt pathway.
Sulfated fuco-manno-glucuronogalactan alleviates pancreatic beta cell senescence via PI3K/AKT/FoxO1 pathway.
Alphaherpesvirus upregulates NDRG1 expression to facilitate the nuclear import of viral UL31 and UL34 proteins.
p52-ZER6: a determinant of tumor cell sensitivity to MDM2-p53 binding inhibitors.
Adipose tissue-derived Muse cells promote autophagy and oxidative stress tolerance in human epidermal melanocytes.
One Stone, Two Birds: A Peptide-Au(I) Infinite Coordination Supermolecule for the Confederate Physical and Biological Radiosensitization in Cancer Radiation Therapy.
HSPA5 Promotes the Proliferation, Metastasis and Regulates Ferroptosis of Bladder Cancer.
Ganoderic Acid A and Its Amide Derivatives as Potential Anti-Cancer Agents by Regulating the p53-MDM2 Pathway: Synthesis and Biological Evaluation.
Ginsenoside Rg2 Promotes the Proliferation and Stemness Maintenance of Porcine Mesenchymal Stem Cells through Autophagy Induction.
Mitochondrial citrate accumulation triggers senescence of alveolar epithelial cells contributing to pulmonary fibrosis in mice.
Peripheral Klotho protects the kidney and brain by regulating M2a/M2c macrophage polarization in d-gal-treated aged mice.
Exercise protects aged mice against coronary endothelial senescence via FUNDC1-dependent mitophagy.
Senomorphic effect of diphenyleneiodonium through AMPK/MFF/DRP1 mediated mitochondrial fission.
Characterizing the specific mechanism of series processed Coptidis Rhizoma by multi-organ metabolomics combined with network pharmacology and molecular docking.
EIF4A3-induced Circ_0001187 facilitates AML suppression through promoting ubiquitin-proteasomal degradation of METTL3 and decreasing m6A modification level mediated by miR-499a-5p/RNF113A pathway.
Morusin shows potent antitumor activity for melanoma through apoptosis induction and proliferation inhibition.
METTL3-mediated m6A modification of SIRT1 mRNA inhibits progression of endometriosis by cellular senescence enhancing.
Transgelin promotes ferroptosis to inhibit the malignant progression of esophageal squamous cell carcinoma.
EETs alleviate alveolar epithelial cell senescence by inhibiting endoplasmic reticulum stress through the Trim25/Keap1/Nrf2 axis.
Quercetin attenuates angiotensin II-induced proliferation of vascular smooth muscle cells and p53 pathway activation in vitro and in vivo.
Design, synthesis, and SAR study of novel flavone 1,2,4-oxadiazole derivatives with anti-inflammatory activities for the treatment of Parkinson's disease.
Exosomes from tannic acid-stimulated macrophages accelerate wound healing through miR-221-3p mediated fibroblasts migration by targeting CDKN1b.
Artesunate alleviates 5-fluorouracil-induced intestinal damage by suppressing cellular senescence and enhances its antitumor activity.
Lysine butyrylation of HSP90 regulated by KAT8 and HDAC11 confers chemoresistance.
Cold exposure protects against medial arterial calcification development via autophagy.
Long noncoding RNA LINC01594 inhibits the CELF6-mediated splicing of oncogenic CD44 variants to promote colorectal cancer metastasis.
Acetylation Targeting Chimera Enables Acetylation of the Tumor Suppressor p53.
HPV-CCDC106 integration promotes cervical cancer progression by facilitating the high expression of CCDC106 after HPV E6 splicing.
RNA-sequencing analysis reveals the potential molecular mechanism of RAD54B in the proliferation of inflamed human dental pulp cells.
Verniciflavanol A, a profisetinidin-type-4-arylflavan-3-ol from toxicodendron vernicifluum protects SH-SY5Y cells against H2O2-Induced oxidative stress.
Dietary selenium excess affected spermatogenesis via DNA damage and telomere-related cell senescence and apoptosis in mice.
The CDK inhibitor AT7519 inhibits human glioblastoma cell growth by inducing apoptosis, pyroptosis and cell cycle arrest.
Pold4 is dispensable for mouse development, DNA replication and DNA repair.
Involvement of JNK signaling in Aspergillus fumigatus-induced inflammatory factors release in bronchial epithelial cells.
PKR deficiency delays vascular aging via inhibiting GSDMD-mediated endothelial cell hyperactivation.
Structural basis of bacterial effector protein azurin targeting tumor suppressor p53 and inhibiting its ubiquitination.
Evaluation of toxicological effects of bisphenol S with an in vitro human bone marrow mesenchymal stem cell: Implications for bone health.
Molecular mechanism of the miR-7/BCL2L1/P53 signaling axis regulating the progression of hepatocellular carcinoma.
Staphylococcal enterotoxin A induces DNA damage in hepatocytes and liver tissues.
SPY1 inhibits neuronal ferroptosis in amyotrophic lateral sclerosis by reducing lipid peroxidation through regulation of GCH1 and TFR1.
Navitoclax (ABT-263) Rejuvenates Human Skin by Eliminating Senescent Dermal Fibroblasts in a Mouse/Human Chimeric Model.
Hypoxia aggravates the burden of yellowstripe goby (Mugilogobius chulae) under atorvastatin exposure.
Exploration the role of INHBA in Hu sheep granulosa cells using RNA-Seq.
Minnelide combined with Angptl3 knockout completely protects mice with adriamycin nephropathy via suppression of TGF-β1-Smad2 and p53 pathways.
Revealing active components and action mechanism of Fritillariae Bulbus against non-small cell lung cancer through spectrum-effect relationship and proteomics.
Combination of DNA Damage, Autophagy, and ERK Inhibition: Novel Evodiamine-Inspired Multi-Action Pt(IV) Prodrugs with High-Efficiency and Low-Toxicity Antitumor Activity.
Dual regulation of Akt and glutathione caused by isoalantolactone effectively triggers human ovarian cancer cell apoptosis.
BMAL1/p53 mediating bronchial epithelial cell autophagy contributes to PM2.5-aggravated asthma.
Pyrrolyldihydropyrazino[1,2-a]indoletrione Analogue Microtubule Inhibitor Induces Cell-Cycle Arrest and Apoptosis in Colorectal Cancer Cells.
N(6)-methyladenosine modification in 18S rRNA promotes tumorigenesis and chemoresistance via HSF4b/HSP90B1/mutant p53 axis.
Porphyromonas gingivalis Outer Membrane Vesicles Promote Apoptosis via msRNA-Regulated DNA Methylation in Periodontitis.
PI3K δ inhibitor PI-3065 induces apoptosis in hepatocellular carcinoma cells by targeting survivin.
Core-shell SERS nanotags-based western blot.
Long noncoding RNA RMRP ameliorates doxorubicin-induced apoptosis by interacting with PFN1 in a P53-Dependent manner.
Ferritinophagy-mediated apoptosis and paraptosis induction involved MAPK and PI3K/AKT pathway in mechanism of an iron chelator.
Epoxyeicosatrienoic acids alleviate alveolar epithelial cell senescence by inhibiting mitophagy through NOX4/Nrf2 pathway.
7-Ketocholesterol accelerates pancreatic β-cell senescence by inhibiting the SIRT1/CDK4-Rb-E2F1 signaling pathway.
A protocol to investigate the effects of lncRNAs on in vivo protein-protein interactions using proximity ligation assay.
Dapagliflozin impedes endothelial cell senescence by activating the SIRT1 signaling pathway in type 2 diabetes.
Effect of evernic acid on human breast cancer MCF-7 and MDA-MB-453 cell lines via thioredoxin reductase 1: A molecular approach.
Ginkgolide A targets forkhead box O1 to protect against lipopolysaccharide-induced septic cardiomyopathy.
N-Acetylserotonin Protects Rat Nucleus Pulposus Cells Against Oxidative Stress Injury by Activating the PI3K/AKT Signaling Pathway.
LIM domain-containing protein Ajuba inhibits chemotherapy-induced apoptosis by negatively regulating p53 stability in colorectal cancer cells.
CACYBP knockdown inhibits progression of prostate cancer via p53.
HPV18 E6 inhibits α-ketoglutarate-induced pyroptosis of esophageal squamous cell carcinoma cells via the P53/MDH1/ROS/GSDMC pathway.
MicroRNA‑30a‑5p regulates cypermethrin-induced apoptosis of Sertoli cells by targeting KLF9 in vitro.
A New Type of Endometrial Cancer Models in Mice Revealing the Functional Roles of Genetic Drivers and Exploring their Susceptibilities.
The cellular uptake of Cordyceps sinensis exopolysaccharide‑selenium nanoparticles and their induced apoptosis of HepG2 cells via mitochondria- and death receptor-mediated pathways.
A p53/LINC00324 positive feedback loop suppresses tumor growth by counteracting SET-mediated transcriptional repression.
Quercetin ameliorates oxidative stress-induced senescence in rat nucleus pulposus-derived mesenchymal stem cells via the miR-34a-5p/SIRT1 axis.
Network pharmacology prediction and experimental verification of Rhubarb-Peach Kernel promoting apoptosis in endometriosis.
Exploring the regulatory mechanism of tRNA-derived fragments 36 in acute pancreatitis based on small RNA sequencing and experiments.
The Active Fraction of Polyrhachis vicina Roger (AFPR) activates ERK to cause necroptosis in colorectal cancer.
p53 inhibits the Urea cycle and represses polyamine biosynthesis in glioma cell lines.
Acceleration of melanocyte senescence by the proinflammatory cytokines IFNγ and TNFα impairs the repigmentation response of vitiligo patients to narrowband ultraviolet B (NBUVB) phototherapy.
Cardamonin alleviates chondrocytes inflammation and cartilage degradation of osteoarthritis by inhibiting ferroptosis via p53 pathway.
Circular RNA circ0104103 inhibits colorectal cancer progression through interactions with HuR and miR-373-5p.
p53 protects against alcoholic fatty liver disease via ALDH2 inhibition.
Chito-oligosaccharides and macrophages have synergistic effects on improving ovarian stem cells function by regulating inflammatory factors.
AKR1B1 Represses Glioma Cell Proliferation through p38 MAPK-Mediated Bcl-2/BAX/Caspase-3 Apoptotic Signaling Pathways.
Upregulation of TMEM40 is associated with the malignant behavior and promotes tumor progression in cervical cancer.
Excessive serine from the bone marrow microenvironment impairs megakaryopoiesis and thrombopoiesis in Multiple Myeloma.
MiR-122-5p regulates the mevalonate pathway by targeting p53 in non-small cell lung cancer.
Hydrogen Sulfide Inhibits Ferroptosis in Cardiomyocytes to Protect Cardiac Function in Aging Rats.
6-Shogaol Inhibits Oxidative Stress-Induced Rat Vascular Smooth Muscle Cell Apoptosis by Regulating OXR1-p53 Axis.
Hydrogen sulfide against preeclampsia exposure-induced oxidative mitochondrial damage in HTR-8/SVneo cells.
Proanthocyanidin oligomers extract from hawthorn mediates cell cycle arrest, apoptosis, and lysosome vacuolation on HCT116 cells.
Bovine milk exosomes affected proliferation of macrophages under hypoxia.
Jatrorrhizine reduces myocardial infarction-induced apoptosis and fibrosis through inhibiting p53 and TGF-β1/Smad2/3 pathways in mice.
Small Nucleolar RNA and C/D Box 15B Regulate the TRIM25/P53 Complex to Promote the Development of Endometrial Cancer.
Pygo1 Regulates the Behavior of Human Non-Small-Cell Lung Cancer via the Wnt/β-Catenin Pathway.
Overcoming Basal Autophagy, Kangai Injection Enhances Cisplatin Cytotoxicity by Regulating FOXO3a-Dependent Autophagic Cell Death and Apoptosis in Human Lung Adenocarcinoma A549/DDP Cells.
Using Network Pharmacology and Animal Experiment to Investigate the Therapeutic Mechanisms of Polydatin against Vincristine-Induced Neuropathic Pain.
Cigarette Smoke Exposure Increases Glucose-6-phosphate Dehydrogenase, Autophagy, Fibrosis, and Senescence in Kidney Cells In Vitro and In Vivo.
Schwann Cells Accelerate Osteogenesis via the Mif/CD74/FOXO1 Signaling Pathway In Vitro.
Rg1 Protects Hematopoietic Stem Cells from LiCl-Induced Oxidative Stress via Wnt Signaling Pathway.
Tanshinone IIA Accomplished Protection against Radiation-Induced Cardiomyocyte Injury by Regulating the p38/p53 Pathway.
1,25(OH)(2)D(3) Mitigates Oxidative Stress-Induced Damage to Nucleus Pulposus-Derived Mesenchymal Stem Cells through PI3K/Akt Pathway.
Disturbance of Fatty Acid Metabolism Promoted Vascular Endothelial Cell Senescence via Acetyl-CoA-Induced Protein Acetylation Modification.
Mutant p53 achieved Gain-of-Function by promoting tumor growth and immune escape through PHLPP2/AKT/PD-L1 pathway.
Flap endonuclease 1 Facilitated Hepatocellular Carcinoma Progression by Enhancing USP7/MDM2-mediated P53 Inactivation.
DNA Polymerase Gamma Recovers Mitochondrial Function and Inhibits Vascular Calcification by Interacted with p53.
Rab31 promotes the invasion and metastasis of cervical cancer cells by inhibiting MAPK6 degradation.
TEAD1 Silencing Regulates Cell Proliferation and Resistance to 5-Fluorouracil in Cutaneous Squamous Cell Carcinoma.
LncRNA LINC00460 facilitates the proliferation and metastasis of renal cell carcinoma via PI3K/AKT signaling pathway.
Exploring the pharmacological mechanisms of icaritin against nasopharyngeal carcinoma via network pharmacology and experimental validation.
QishenYiqi dripping pill protects against myocardial ischemia/reperfusion injury via suppressing excessive autophagy and NLRP3 inflammasome based on network pharmacology and experimental pharmacology.
Antisense Oligonucleotide-Based Therapy on miR-181a-5p Alleviates Cartilage Degradation of Temporomandibular Joint Osteoarthritis via Promoting SIRT1.
Phyllanthus Niruri L. Exerts Protective Effects Against the Calcium Oxalate-Induced Renal Injury via Ellgic Acid.
Oridonin Delays Aging Through the AKT Signaling Pathway.
Gallic acid suppresses the progression of triple-negative breast cancer HCC1806 cells via modulating PI3K/AKT/EGFR and MAPK signaling pathways.
HPV16 E6-Activated OCT4 Promotes Cervical Cancer Progression by Suppressing p53 Expression via Co-Repressor NCOR1.
Molecular Classification in Patients With Endometrial Cancer After Fertility-Preserving Treatment: Application of ProMisE Classifier and Combination of Prognostic Evidence.
Loss of CMTM6 promotes DNA damage-induced cellular senescence and antitumor immunity.
Inflammation and fibrosis in the coal dust-exposed lung described by confocal Raman spectroscopy.
Characterization of transcriptional landscape in bone marrow-derived mesenchymal stromal cells treated with aspirin by RNA-seq.
PLK1 Mitigates Intervertebral Disc Degeneration by Delaying Senescence of Nucleus Pulposus Cells.
Harpagoside Protects Against Doxorubicin-Induced Cardiotoxicity via P53-Parkin-Mediated Mitophagy.
TP53 loss-of-function causes vulnerability to autophagy inhibition in aggressive prostate cancer.
UFL1 alleviates ER stress and apoptosis stimulated by LPS via blocking the ferroptosis pathway in human granulosa-like cells.
Transmembrane protein 121 as a novel inhibitor of cervical cancer metastasis.
Chronic restraint stress promotes gastric epithelial malignant transformation by activating the Akt/p53 signaling pathway via ADRB2.
Elevation of effective p53 expression sensitizes wild-type p53 breast cancer cells to CDK7 inhibitor THZ1.
5-Methoxyflavone-induced AMPKα activation inhibits NF-κB and P38 MAPK signaling to attenuate influenza A virus-mediated inflammation and lung injury in vitro and in vivo.
HOXA5 inhibits the proliferation of extrahepatic cholangiocarcinoma cells by enhancing MXD1 expression and activating the p53 pathway.
The therapeutic effect of KSP inhibitors in preclinical models of cholangiocarcinoma.
Neuropeptide-Functionalized Gold Nanorod Enhanced Cellular Uptake and Improved In Vitro Photothermal Killing in LRP1-Positive Glioma Cells.
Senescent Phenotype of Astrocytes Leads to Activation of BV2 Microglia and N2a Neuronal Cells Death.
P53 regulates mitochondrial biogenesis via transcriptionally induction of mitochondrial ribosomal protein L12.
Functional Phosphoproteomics in Cancer Chemoresistance Using CRISPR-Mediated Base Editors.
Metabolism-Based Molecular Subtyping Endows Effective Ketogenic Therapy in p53-Mutant Colon Cancer.
p53 gene delivery via a recombinant Salmonella enterica Typhimurium leads to human bladder carcinoma cell death in vitro.
In vitro and in vivo effects of hyperglycemia and diabetes mellitus on nucleus pulposus cell senescence.
Transcription factor YY1 contributes to human melanoma cell growth through modulating the p53 signalling pathway.
Protective Effect of Manganese on Apoptosis and Mitochondrial Function of Heat-Stressed Primary Chick Embryonic Myocardial Cells.
The exon 12-containing LHX6 isoforms promote cervical cancer cell proliferation by regulating the MAPK signaling pathway.
NOP53 undergoes liquid-liquid phase separation and promotes tumor radio-resistance.
SF3B4 Depletion Retards the Growth of A549 Non-Small Cell Lung Cancer Cells via UBE4B-Mediated Regulation of p53/p21 and p27 Expression.
Relationship between Neuroglial Apoptosis and Neuroinflammation in the Epileptic Focus of the Brain and in the Blood of Patients with Drug-Resistant Epilepsy.
Sphingosine-1-Phosphate Alleviates Irradiation Induced Salivary Gland Hypofunction through Preserving Endothelial Cells and Resident Macrophages.
Design, Synthesis and Evaluation of Novel 1,4-Disubstituted Piperazine-2,5-dione Derivatives as Antioxidants against H(2)O(2)-Induced Oxidative Injury via the IL-6/Nrf2 Loop Pathway.
Astaxanthin attenuates osteoarthritis progression via inhibiting ferroptosis and regulating mitochondrial function in chondrocytes.
Tumor suppressor LHPP suppresses cell proliferation and epithelial-mesenchymal transition in hepatocellular carcinoma cell lines.
Metformin suppresses vascular smooth muscle cell senescence by promoting autophagic flux.
Matrix stiffness exacerbates the proinflammatory responses of vascular smooth muscle cell through the DDR1-DNMT1 mechanotransduction axis.
Maizediterpene D from the roots of Zea mays L. alleviates hydrogen peroxide induced oxidative stress and improves cell survival by activation of TrkB/IGF-1R crosstalk pathways.
Andrographolide elevates tumor necrosis factor-related apoptosis-inducing ligand lethality through reactive oxygen species accumulation and gasdermin E cleavage in breast cancer cells.
Derepression of the USP22-FASN axis by p53 loss under oxidative stress drives lipogenesis and tumorigenesis.
Identification of 3-Phenylquinoline Derivative PQ1 as an Antagonist of p53 Transcriptional Activity.
Porcine Circovirus 2 Activates the PERK-Reactive Oxygen Species Axis To Induce p53 Phosphorylation with Subsequent Cell Cycle Arrest at S Phase in Favor of Its Replication.
miR-3168 promotes hepatocellular carcinoma progression via downregulating p53.
Potential mechanisms underlying the promoting effects of 3D collagen scaffold culture on stemness and drug resistance of glioma cells.
Effects of thymoquinone against angiotensin II‑induced cardiac damage in apolipoprotein E‑deficient mice.
Urea transporter B downregulates polyamines levels in melanoma B16 cells via p53 activation.
MDM2 E3 ligase activity is essential for p53 regulation and cell cycle integrity.
Rho family GTPase 1 (RND1), a novel regulator of p53, enhances ferroptosis in glioblastoma.
A novel 3'tRNA-derived fragment tRF-Val promotes proliferation and inhibits apoptosis by targeting EEF1A1 in gastric cancer.
Genetic Aberrations and Interaction of NEK2 and TP53 Accelerate Aggressiveness of Multiple Myeloma.
USP22-mediated deubiquitination of PTEN inhibits pancreatic cancer progression by inducing p21 expression.
Hepatoprotective mechanism of Silybum marianum on nonalcoholic fatty liver disease based on network pharmacology and experimental verification.
Novel insights into the mechanisms by which lncRNA HOTAIR regulates migration and invasion in HeLa cells.
Multifunctional photodynamic/photothermal nano-agents for the treatment of oral leukoplakia.
p62 Promotes the Mitochondrial Localization of p53 through Its UBA Domain and Participates in Regulating the Sensitivity of Ovarian Cancer Cells to Cisplatin.
USP49-Mediated Histone H2B Deubiquitination Regulates HCT116 Cell Proliferation through MDM2-p53 Axis.
Combined Inactivation of CTPS1 and ATR Is Synthetically Lethal to MYC-Overexpressing Cancer Cells.
Inhibition of STAT3(Y705) phosphorylation by Stattic suppresses proliferation and induces mitochondrial-dependent apoptosis in pancreatic cancer cells.
SRSF1 governs progenitor-specific alternative splicing to maintain adult epithelial tissue homeostasis and renewal.
Exercise suppresses mouse systemic AApoAII amyloidosis through enhancement of the p38 MAPK signaling pathway.
The serum soluble Klotho alleviates cardiac aging and regulates M2a/M2c macrophage polarization via inhibiting TLR4/Myd88/NF-κB pathway.
Pyrimethamine inhibits cell growth by inducing cell senescence and boosting CD8(+) T-cell mediated cytotoxicity in colorectal cancer.
p53 m(6)A modulation sensitizes hepatocellular carcinoma to apatinib through apoptosis.
The role of ALOX15B in heat stress-induced apoptosis of porcine sertoli cells.
DEHP induces ferroptosis in testes via p38α-lipid ROS circulation and destroys the BTB integrity.
Novel Flavan-3,4-diol vernicidin B from Toxicodendron Vernicifluum (Anacardiaceae) as potent antioxidant via IL-6/Nrf2 cross-talks pathways.
Stress-induced epinephrine promotes epithelial-to-mesenchymal transition and stemness of CRC through the CEBPB/TRIM2/P53 axis.
p53-Dependent Mitochondrial Compensation in Heart Failure With Preserved Ejection Fraction.
Synthesis and structure-activity relationship study of a potent MHO7 analogue as potential anti-triple negative breast cancer agent.
Interleukin-13 promotes cellular senescence through inducing mitochondrial dysfunction in IgG4-related sialadenitis.
Analysis by transcriptomics and metabolomics for the proliferation inhibition and dysfunction through redox imbalance-mediated DNA damage response and ferroptosis in male reproduction of mice and TM4 Sertoli cells exposed to PM(2.5).
Inhibition of the lncRNA MIAT prevents podocyte injury and mitotic catastrophe in diabetic nephropathy.
Inhibiting the IRE1α Axis of the Unfolded Protein Response Enhances the Antitumor Effect of AZD1775 in TP53 Mutant Ovarian Cancer.
MG53 protein rejuvenates hUC-MSCs and facilitates their therapeutic effects in AD mice by activating Nrf2 signaling pathway.
Low doses of niclosamide and quinacrine combination yields synergistic effect in melanoma via activating autophagy-mediated p53-dependent apoptosis.
Effect of alfalfa substituted with ramie on the expression of apoptotic genes in the gastrointestinal tracts of goats.
The Role of Ferroptosis in the Damage of Human Proximal Tubule Epithelial Cells Caused by Perfluorooctane Sulfonate.
COX-2/sEH Dual Inhibitor Alleviates Hepatocyte Senescence in NAFLD Mice by Restoring Autophagy through Sirt1/PI3K/AKT/mTOR.
Targeted demethylation of the SLC5A7 promotor inhibits colorectal cancer progression.
Cancer cells corrupt normal epithelial cells through miR-let-7c-rich small extracellular vesicle-mediated downregulation of p53/PTEN.
Diffractaic acid, a novel TrxR1 inhibitor, induces cytotoxicity, apoptosis, and antimigration in human breast cancer cells.
Identification of a novel native peptide derived from 60S ribosomal protein L23a that translationally regulates p53 to reduce myocardial ischemia-reperfusion.
Integrating network pharmacology deciphers the action mechanism of Zuojin capsule in suppressing colorectal cancer.
A new FGF1 variant protects against adriamycin-induced cardiotoxicity via modulating p53 activity.
m6A demethylation of cytidine deaminase APOBEC3B mRNA orchestrates arsenic-induced mutagenesis.
Survivin suppression heightens BZML-induced mitotic catastrophe to overcome multidrug resistance by removing therapy-induced senescent A549/Taxol cells.
Persistent high glucose induced EPB41L4A-AS1 inhibits glucose uptake via GCN5 mediating crotonylation and acetylation of histones and non-histones.
Integrative investigation of the TF-miRNA coregulatory network involved in the inhibition of breast cancer cell proliferation by resveratrol.
MiR-187 regulates the proliferation, migration and invasion of human trophoblast cells by repressing BCL6-mediated activation of PI3K/AKT signaling.
Berberine ameliorates erectile dysfunction in rats with streptozotocin-induced diabetes mellitus through the attenuation of apoptosis by inhibiting the SPHK1/S1P/S1PR2 and MAPK pathways.
Anticancer effects of myricetin derivatives in non-small cell lung cancer in vitro and in vivo.
Hepatocyte nuclear factor 4 gamma (HNF4G) is correlated with poor prognosis and promotes tumor cell growth by inhibiting caspase-dependent intrinsic apoptosis in colorectal cancer.
Design and synthesis of marine sesterterpene analogues as novel estrogen receptor α degraders for breast cancer treatment.
Targeting and neutralizing human epididymis protein 4 by novel nanobodies to suppress ovarian cancer cells and attenuate cisplatin resistance.
Pan-cancer analysis of oncogenic role of Programmed Cell Death 2 Like (PDCD2L) and validation in colorectal cancer.
The dual role of p62 in ferroptosis of glioblastoma according to p53 status.
Blocking iASPP/Nrf2/M-CSF axis improves anti-cancer effect of chemotherapy-induced senescence by attenuating M2 polarization.
Ginsenoside Rh4 Suppressed Metastasis of Lung Adenocarcinoma via Inhibiting JAK2/STAT3 Signaling.
Fulminant lung fibrosis in non-resolvable COVID-19 requiring transplantation.
Resveratrol inhibits the progression of premature senescence partially by regulating v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA) and sirtuin 1 (SIRT1).
Pseudogene CSPG4P12 affects the biological behavior of non‑small cell lung cancer by Bcl‑2/Bax mitochondrial apoptosis pathway.
Polysaccharide ORP-1 isolated from Oudemansiella raphanipes ameliorates age-associated intestinal epithelial barrier dysfunction in Caco-2 cells monolayer.
VLA-4 suppression by senescence signals regulates meningeal immunity and leptomeningeal metastasis.
The C-terminus of Gain-of-Function Mutant p53 R273H Is Required for Association with PARP1 and Poly-ADP-Ribose.
Inhibition of TIGAR Increases Exogenous p53 and Cisplatin Combination Sensitivity in Lung Cancer Cells by Regulating Glycolytic Flux.
FUT2 Facilitates Autophagy and Suppresses Apoptosis via p53 and JNK Signaling in Lung Adenocarcinoma Cells.
Inhibition of thioredoxin reductase 1 by vulpinic acid suppresses the proliferation and migration of human breast carcinoma.
Chitosan-Gelatin-EGCG Nanoparticle-Meditated LncRNA TMEM44-AS1 Silencing to Activate the P53 Signaling Pathway for the Synergistic Reversal of 5-FU Resistance in Gastric Cancer.
PM2.5-Induced Programmed Myocardial Cell Death via mPTP Opening Results in Deteriorated Cardiac Function in HFpEF Mice.
LncRNA SNHG11 promotes the malignant transformation of human bronchial epithelial cells induced by beryllium sulfate.
Long noncoding RNA CERS6-AS1 modulates glucose metabolism and tumor progression in hepatocellular carcinoma by promoting the MDM2/p53 signaling pathway.
p53 Binding Sites in Long Terminal Repeat 5Hs (LTR5Hs) of Human Endogenous Retrovirus K Family (HML-2 Subgroup) Play Important Roles in the Regulation of LTR5Hs Transcriptional Activity.
BCAS3 accelerates glioblastoma tumorigenesis by restraining the P53/GADD45α signaling pathway.
TDP-43 upregulates lipid metabolism modulator ABHD2 to suppress apoptosis in hepatocellular carcinoma.
Knockdown of RRM1 in tumor cells promotes radio-/chemotherapy induced ferroptosis by regulating p53 ubiquitination and p21-GPX4 signaling axis.
Downregulation of CPT2 promotes proliferation and inhibits apoptosis through p53 pathway in colorectal cancer.
Genetic Catalytic Inactivation of GRK5 Impairs Cardiac Function in Mice Via Dysregulated P53 Levels.
Silence of MLK3 alleviates lipopolysaccharide-induced lung epithelial cell injury via inhibiting p53-mediated ferroptosis.
Novel CDK9 inhibitor oroxylin A promotes wild-type P53 stability and prevents hepatocellular carcinoma progression by disrupting both MDM2 and SIRT1 signaling.
TIM-1 promotes proliferation and metastasis, and inhibits apoptosis, in cervical cancer through the PI3K/AKT/p53 pathway.
Ginsenoside Rk1 regulates glutamine metabolism in hepatocellular carcinoma through inhibition of the ERK/c-Myc pathway.
CYLD deficiency enhances metabolic reprogramming and tumor progression in nasopharyngeal carcinoma via PFKFB3.
Activation of Esterase D by FPD5 Inhibits Growth of A549 Lung Cancer Cells via JAB1/p53 Pathway.
Mandarin Fish (Siniperca chuatsi) p53 Regulates Glutaminolysis Induced by Virus via the p53/miR145-5p/c-Myc Pathway in Chinese Perch Brain Cells.
RETREG1-mediated ER-phagy activation induced by glucose deprivation alleviates nucleus pulposus cell damage via ER stress pathway.
LncRNA LYPLAL1-AS1 rejuvenates human adipose-derived mesenchymal stem cell senescence via transcriptional MIRLET7B inactivation.
Predict the role of lncRNA in kidney aging based on RNA sequencing.
The E3 Ligase RNF157 Inhibits Lens Epithelial Cell Apoptosis by Negatively Regulating p53 in Age-Related Cataracts.
CircSCAP interacts with SF3A3 to inhibit the malignance of non-small cell lung cancer by activating p53 signaling.
Chaperone-mediated autophagy plays an important role in regulating retinal progenitor cell homeostasis.
Utilizing network pharmacology and molecular docking to explore the underlying mechanism of Guizhi Fuling Wan in treating endometriosis.
Construction of a Novel Ferroptosis-Related Gene Signature of Atherosclerosis.
Single-Cell Analysis Identify Transcription Factor BACH1 as a Master Regulator Gene in Vascular Cells During Aging.
p53-GSDME Elevation: A Path for CDK7 Inhibition to Suppress Breast Cancer Cell Survival.
Hengshun Aromatic Vinegar Ameliorates Vascular Endothelial Injury via Regulating PKCζ-Mediated Oxidative Stress and Apoptosis.
Gentiopicroside Inhibits Cell Growth and Migration on Cervical Cancer via the Reciprocal MAPK/Akt Signaling Pathways.
Huxie Huaji Ointment Induced Apoptosis of Liver Cancer Cells In Vivo and In Vitro by Activating the Mitochondrial Pathway.
Escin Sodium Improves the Prognosis of Acute Pancreatitis via Promoting Cell Apoptosis by Suppression of the ERK/STAT3 Signaling Pathway.
Metformin-Induced MicroRNA-34a-3p Downregulation Alleviates Senescence in Human Dental Pulp Stem Cells by Targeting CAB39 through the AMPK/mTOR Signaling Pathway.
Design, Synthesis, and Biological Evaluation of a Novel Aminothiol Compound as Potential Radioprotector.
Oridonin Promotes Apoptosis and Restrains the Viability and Migration of Bladder Cancer by Impeding TRPM7 Expression via the ERK and AKT Signaling Pathways.
FAM134B-Mediated ER-phagy Upregulation Attenuates AGEs-Induced Apoptosis and Senescence in Human Nucleus Pulposus Cells.
Novel biomarkers for post-contrast acute kidney injury identified from long non-coding RNA expression profiles.
CDC20 regulates the cell proliferation and radiosensitivity of P53 mutant HCC cells through the Bcl-2/Bax pathway.
p53 Promoted Ferroptosis in Ovarian Cancer Cells Treated with Human Serum Incubated-Superparamagnetic Iron Oxides.
Delivery of Rapamycin by Liposomes Synergistically Enhances the Chemotherapy Effect of 5-Fluorouracil on Colorectal Cancer.
Computational Systems Pharmacology, Molecular Docking and Experiments Reveal the Protective Mechanism of Li-Da-Qian Mixture in the Treatment of Glomerulonephritis.
RNA-binding Protein MBNL2 regulates Cancer Cell Metastasis through MiR-182-MBNL2-AKT Pathway.
Myricanol Inhibits Platelet Derived Growth Factor-BB-Induced Vascular Smooth Muscle Cells Proliferation and Migration in vitro and Intimal Hyperplasia in vivo by Targeting the Platelet-Derived Growth Factor Receptor-β and NF-κB Signaling.
Qingda Granule Attenuates Angiotensin II-Induced Renal Apoptosis and Activation of the p53 Pathway.
Decipering the Molecular Mechanism of ACE2 Regulating A549 Cells.
A New Chalcone Derivative C49 Reverses Doxorubicin Resistance in MCF-7/DOX Cells by Inhibiting P-Glycoprotein Expression.
Astragalin Inhibits the Proliferation and Migration of Human Colon Cancer HCT116 Cells by Regulating the NF-κB Signaling Pathway.
A novel role of kallikrein-related peptidase 8 in the pathogenesis of diabetic cardiac fibrosis.
Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance.
Human umbilical cord-derived mesenchymal stem cell therapy ameliorates lupus through increasing CD4+ T cell senescence via MiR-199a-5p/Sirt1/p53 axis.
Elevated Sodium Pump α3 Subunit Expression Promotes Colorectal Liver Metastasis via the p53-PTEN/IGFBP3-AKT-mTOR Axis.
Targeting Mutated p53 Dependency in Triple-Negative Breast Cancer Cells Through CDK7 Inhibition.
Pterostilbene and its nicotinate derivative ameliorated vascular endothelial senescence and elicited endothelium-dependent relaxations via activation of sirtuin 1.
Iron deficiency exacerbates cisplatin- or rhabdomyolysis-induced acute kidney injury through promoting iron-catalyzed oxidative damage.
A self-amplified nanocatalytic system for achieving "1 + 1 + 1 > 3" chemodynamic therapy on triple negative breast cancer.
Treatment of early brain injury after subarachnoid hemorrhage in the rat model by inhibiting p53-induced ferroptosis.
Increased tissue stiffness triggers contractile dysfunction and telomere shortening in dystrophic cardiomyocytes.
Effect of different exercise training intensities on age-related cardiac damage in male mice.
Avicularin suppresses cartilage extracellular matrix degradation and inflammation via TRAF6/MAPK activation.
The protective effects of resveratrol pretreatment in cyclophosphamide-induced rat ovarian injury: an vivo study.
Advanced Maternal Age-associated SIRT1 Deficiency Compromises Trophoblast Epithelial-Mesenchymal Transition through an Increase in Vimentin Acetylation.
Design, synthesis and antitumor evaluation of novel chiral diaryl substituted azetidin-2-one derivatives as tubulin polymerization inhibitors.
The biological effect of cobalt chloride mimetic-hypoxia on nucleus pulposus cells and the comparability with physical hypoxia in vitro.
Chitosan oligosaccharides packaged into rat adipose mesenchymal stem cells-derived extracellular vesicles facilitating cartilage injury repair and alleviating osteoarthritis.
The FOXM1/RNF26/p57 axis regulates the cell cycle to promote the aggressiveness of bladder cancer.
Reactive Oxygen Species Mediate 6c-Induced Mitochondrial and Lysosomal Dysfunction, Autophagic Cell Death, and DNA Damage in Hepatocellular Carcinoma.
GRIM-19 inhibits proliferation and induces apoptosis in a p53-dependent manner in colorectal cancer cells through the SIRT7/PCAF/MDM2 axis.
A-24, a steroidal saponin from Allium chinense, induced apoptosis, autophagy and migration inhibition in p53 wild-type and p53-deficient gastric cancer cells.
Effects and Mechanisms of Synaptotagmin-7 in the Hippocampus on Cognitive Impairment in Aging Mice.
Low-dose exposure to black carbon significantly increase lung injury of cadmium by promoting cellular apoptosis.
Betaine alleviates right ventricular failure via regulation of Rho A/ROCK signaling pathway in rats with pulmonary arterial hypertension.
Protective Effects of L-Theanine on IPEC-J2 Cells Growth Inhibition Induced by Dextran Sulfate Sodium via p53 Signaling Pathway.
The Y14-p53 regulatory circuit in megakaryocyte differentiation and thrombocytopenia.
miR-6745-TIMP1 axis inhibits cell growth and metastasis in gastric cancer.
Protection of the enhanced Nrf2 deacetylation and its downstream transcriptional activity by SIRT1 in myocardial ischemia/reperfusion injury.
Nicotinamide Supplementation Attenuates Renal Interstitial Fibrosis via Boosting the Activity of Sirtuins.
MFG-E8 regulated by miR-99b-5p protects against osteoarthritis by targeting chondrocyte senescence and macrophage reprogramming via the NF-κB pathway.
LncRNA CD27-AS1 promotes acute myeloid leukemia progression through the miR-224-5p/PBX3 signaling circuit.
AIMP3 inhibits cell growth and metastasis of lung adenocarcinoma through activating a miR-96-5p-AIMP3-p53 axis.
Melatonin inhibits proliferation and viability and promotes apoptosis in colorectal cancer cells via upregulation of the microRNA-34a/449a cluster.
Sodium hydrosulfide alleviates dexamethasone-induced cell senescence and dysfunction through targeting the miR-22/sirt1 pathway in osteoblastic MC3T3-E1 cells.
Metformin attenuates hyperlipidaemia-associated vascular calcification through anti-ferroptotic effects.
Aberrant elevation of GDF8 impairs granulosa cell glucose metabolism via upregulating SERPINE1 expression in patients with PCOS.
BMP5 silencing inhibits chondrocyte senescence and apoptosis as well as osteoarthritis progression in mice.
Pregnane X receptor (PXR) protects against cisplatin-induced acute kidney injury in mice.
Key proteins of proteome underlying sperm malformation of rats exposed to low fenvalerate doses are highly related to P53.
The p53/NF-kappaB-dependent induction of sestrin2 by amyloid-beta peptides exerts antioxidative actions in neurons.
Paricalcitol inhibits oxidative stress-induced cell senescence of the bile duct epithelium dependent on modulating Sirt1 pathway in cholestatic mice.
Frame-shift mediated reduction of gain-of-function p53 R273H and deletion of the R273H C-terminus in breast cancer cells result in replication-stress sensitivity.
PRDX2 promotes the proliferation of colorectal cancer cells by increasing the ubiquitinated degradation of p53.
ND‑09 inhibits chronic myeloid leukemia K562 cell growth by regulating BCR‑ABL signaling.
Electroacupuncture at GV20‑GB7 regulates mitophagy to protect against neurological deficits following intracerebral hemorrhage via inhibition of apoptosis.
The Protective Effects of Parathyroid Hormone (1-34) on Cartilage and Subchondral Bone Through Down-Regulating JAK2/STAT3 and WNT5A/ROR2 in a Collagenase-Induced Osteoarthritis Mouse Model.
Phosphorylation of RCC1 on Serine 11 Facilitates G1/S Transition in HPV E7-Expressing Cells.
HO-1 nuclear accumulation and interaction with NPM1 protect against stress-induced endothelial senescence independent of its enzymatic activity.
Hypoxic preconditioning rejuvenates mesenchymal stem cells and enhances neuroprotection following intracerebral hemorrhage via the miR-326-mediated autophagy.
Telomere dysfunction instigates inflammation in inflammatory bowel disease.
Role of ferroptosis induced by a high concentration of calcium oxalate in the formation and development of urolithiasis.
Avasimibe exerts anticancer effects on human glioblastoma cells via inducing cell apoptosis and cell cycle arrest.
Antitumor effects of dioscin in A431 cells via adjusting ATM/p53-mediated cell apoptosis, DNA damage and migration.
Ubiquitin-specific protease 7 promotes ferroptosis via activation of the p53/TfR1 pathway in the rat hearts after ischemia/reperfusion.
miRNA-146a-5p mitigates stress-induced premature senescence of D-galactose-induced primary thymic stromal cells.
Huaier Inhibits Proliferation, Migration, and Invasion of Cutaneous Squamous Cell Carcinoma Cells by Inhibiting the Methylation Levels of CDKN2A and TP53.
Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuate Mitochondrial Damage and Inflammation by Stabilizing Mitochondrial DNA.
Autophagy augments the self-renewal of lung cancer stem cells by the degradation of ubiquitinated p53.
Protective effect of thioredoxin reductase 1 in Parkinson's disease.
Death by histone deacetylase inhibitor quisinostat in tongue squamous cell carcinoma via apoptosis, pyroptosis, and ferroptosis.
Effects of redox interference on the pancreatic mitochondria and the abnormal blood glucose.
The distinct roles of myosin IIA and IIB under compression stress in nucleus pulposus cells.
Piezo type mechanosensitive ion channel component 1 facilitates gastric cancer omentum metastasis.
RabGEF1 functions as an oncogene in U251 glioblastoma cells and is involved in regulating AKT and Erk pathways.
TRPV1 Activation Promotes β-arrestin2 Interaction with the Ribosomal Biogenesis Machinery in the Nucleolus:Implications for p53 Regulation and Neurite Outgrowth.
Red ginseng has stronger anti-aging effects compared to ginseng possibly due to its regulation of oxidative stress and the gut microbiota.
Exercise downregulates HIPK2 and HIPK2 inhibition protects against myocardial infarction.
Simiao Qingwen Baidu decoction inhibits Epstein-Barr virus-induced B lymphoproliferative disease and lytic viral replication.
Non-Structural Protein 5 of Zika Virus Interacts with p53 in Human Neural Progenitor Cells and Induces p53-Mediated Apoptosis.
Effects and mechanisms of probucol on aging-related hippocampus-dependent cognitive impairment.
Deficiency of β-arrestin2 alleviates apoptosis through GRP78-ATF6-CHOP signaling pathway in primary Sjögren's syndrome.
CCT8 recovers WTp53-suppressed cell cycle evolution and EMT to promote colorectal cancer progression.
IGFBP7-AS1 is a p53-responsive long noncoding RNA downregulated by Epstein-Barr virus that contributes to viral tumorigenesis.
The degradation of Rap1GAP via E6AP-mediated ubiquitin-proteasome pathway is associated with HPV16/18-infection in cervical cancer cells.
Endoderm development requires centrioles to restrain p53-mediated apoptosis in the absence of ERK activity.
Oxygen nanocarrier broke the hypoxia trap of solid tumors and rescued transfection efficiency for gene therapy.
Protective Effect of l-Theanine against DSS-Induced Colitis by Regulating the Lipid Metabolism and Reducing Inflammation via the NF-κB Signaling Pathway.
Genomic gain of RRS1 promotes hepatocellular carcinoma through reducing the RPL11-MDM2-p53 signaling.
P53 inhibitor pifithrin-α inhibits ropivacaine-induced neuronal apoptosis via the mitochondrial apoptosis pathway.
Ring finger protein 19A is overexpressed in non-small cell lung cancer and mediates p53 ubiquitin-degradation to promote cancer growth.
Design, synthesis and biological evaluation of novel 2,4-disubstituted quinazoline derivatives targeting H1975 cells via EGFR-PI3K signaling pathway.
MicroRNA-22 contributes to dexamethasone-induced osteoblast differentiation inhibition and dysfunction through targeting caveolin-3 expression in osteoblastic cells.
A novel amphibian-derived peptide alleviated ultraviolet B-induced photodamage in mice.
Inhibition of the P53/P21 Pathway Attenuates the Effects of Senescent Nucleus Pulposus Cell-Derived Exosomes on the Senescence of Nucleus Pulposus Cells.
ASIC1 and ASIC3 mediate cellular senescence of human nucleus pulposus mesenchymal stem cells during intervertebral disc degeneration.
Knockdown of TRIM32 inhibits tumor growth and increases the therapeutic sensitivity to temozolomide in glioma in a p53-dependent and -independent manner.
Withanolides from dietary tomatillo suppress HT1080 cancer cell growth by targeting mutant IDH1.
p53-targeted lncRNA ST7-AS1 acts as a tumour suppressor by interacting with PTBP1 to suppress the Wnt/β-catenin signalling pathway in glioma.
Polychlorinated biphenyl quinone regulates MLKL phosphorylation that stimulates exosome biogenesis and secretion via a short negative feedback loop.
PAQR3 Inhibits Non-small Cell Lung Cancer Growth by Regulating the NF-κB/p53/Bax Axis.
Piperlongumine Attenuates High Calcium/Phosphate-Induced Arterial Calcification by Preserving P53/PTEN Signaling.
Comparison of anticarcinogenic properties of Viburnum opulus and its active compound p-coumaric acid on human colorectal carcinoma.
AURKA Increase the Chemosensitivity of Colon Cancer Cells to Oxaliplatin by Inhibiting the TP53-Mediated DNA Damage Response Genes.
Aging Induced p53/p21 in Genioglossus Muscle Stem Cells and Enhanced Upper Airway Injury.
The Establishment of Esophageal Precancerous Lesion Model by Using p53 Conditional Knockout Mouse in Esophageal Epithelium.
Protective Effects of Cinnamaldehyde against Mesenteric Ischemia-Reperfusion-Induced Lung and Liver Injuries in Rats.
Silencing of ELK3 Induces S-M Phase Arrest and Apoptosis and Upregulates SERPINE1 Expression Reducing Migration in Prostate Cancer Cells.
MFP-FePt-GO Nanocomposites Promote Radiosensitivity of Non-Small Cell Lung Cancer Via Activating Mitochondrial-Mediated Apoptosis and Impairing DNA Damage Repair.
miR-370-3p Alleviates Ulcerative Colitis-Related Colorectal Cancer in Mice Through Inhibiting the Inflammatory Response and Epithelial-Mesenchymal Transition.
Kidney and lung tissue modifications after BDL-induced liver injury in mice are associated with increased expression of IGFBPrP1 and activation of the NF-κB inflammation pathway.
GCNT4 is Associated with Prognosis and Suppress Cell Proliferation in Gastric Cancer.
The Acetone Indigo Red Dehydrating Agent IF203 Induces HepG2 Cell Death Through Cell Cycle Arrest, Autophagy and Apoptosis.
Fibroblast Activation Protein (FAP) Overexpression Induces Epithelial-Mesenchymal Transition (EMT) in Oral Squamous Cell Carcinoma by Down-Regulating Dipeptidyl Peptidase 9 (DPP9).
Overexpression of RNF126 Promotes the Development of Colorectal Cancer via Enhancing p53 Ubiquitination and Degradation.
Down-regulation of USP8 Inhibits Cholangiocarcinoma Cell Proliferation and Invasion.
Chlorogenic Acid Decreases Malignant Characteristics of Hepatocellular Carcinoma Cells by Inhibiting DNMT1 Expression.
STRAP as a New Therapeutic Target for Poor Prognosis of Pancreatic Ductal Adenocarcinoma Patients Mainly Caused by TP53 Mutation.
Transcription Factor EBF1 Over-Expression Suppresses Tumor Growth in vivo and in vitro via Modulation of the PNO1/p53 Pathway in Colorectal Cancer.
Effect of epiberberine from Coptis chinensis Franch on inhibition of tumor growth in MKN-45 xenograft mice.
Cinnamaldehyde protects against rat intestinal ischemia/reperfusion injuries by synergistic inhibition of NF-κB and p53.
Musashi2 promotes the progression of pancreatic cancer through a novel ISYNA1-p21/ZEB-1 pathway.
Antitumor effects of aconitine in A2780 cells via estrogen receptor β‑mediated apoptosis, DNA damage and migration.
A steroidal saponin isolated from Allium chinense simultaneously induces apoptosis and autophagy by modulating the PI3K/Akt/mTOR signaling pathway in human gastric adenocarcinoma.
Synthesis, docking studies and antitumor activity of phenanthroimidazole derivatives as promising c-myc G-quadruplex DNA stabilizers.
Abnormal expression of homeobox c6 in the atherosclerotic aorta and its effect on proliferation and migration of rat vascular smooth muscle cells.
lncRNA STEAP3-AS1 Modulates Cell Cycle Progression via Affecting CDKN1C Expression through STEAP3 in Colon Cancer.
RFX5 promotes the progression of hepatocellular carcinoma through transcriptional activation of KDM4A.
PTEN status determines chemosensitivity to proteasome inhibition in cholangiocarcinoma.
Targeting DNA to the endoplasmic reticulum efficiently enhances gene delivery and therapy.
MicroRNA-128-1-5p attenuates myocardial ischemia/reperfusion injury by suppressing Gadd45g-mediated apoptotic signaling.
The effect and mechanism of 19S proteasome PSMD11/Rpn6 subunit in D-Galactose induced mimetic aging models.
The AKT/GSK3-Mediated Slug Expression Contributes to Oxaliplatin Resistance in Colorectal Cancer via Upregulation of ERCC1.
Bovine Milk Exosomes Affect Proliferation and Protect Macrophages against Cisplatin-Induced Cytotoxicity.
3-Acetyldeoxynivalenol induces lysosomal membrane permeabilization-mediated apoptosis and inhibits autophagic flux in macrophages.
mTOR-autophagy promotes pulmonary senescence through IMP1 in chronic toxicity of methamphetamine.
Involvement of p53 Acetylation in Growth Suppression of Cutaneous T-Cell Lymphomas Induced by HDAC Inhibition.
Huoxin pill attenuates myocardial infarction-induced apoptosis and fibrosis via suppression of p53 and TGF-β1/Smad2/3 pathways.
Identification of osalmid metabolic profile and active metabolites with anti-tumor activity in human hepatocellular carcinoma cells.
Paired like homeodomain 1 and SAM and SH3 domain-containing 1 in the progression and prognosis of head and neck squamous cell carcinoma.
c-Myc inactivation of p53 through the pan-cancer lncRNA MILIP drives cancer pathogenesis.
A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle.
Loss of RAD6B induces degeneration of the cochlea in mice.
NO66 overexpression rescues ethanol-induced cell apoptosis in human AC16 cardiomyocytes by suppressing PTEN and activating the PI3K/Akt signaling.
Metformin promotes the osseointegration of titanium implants under osteoporotic conditions by regulating BMSCs autophagy, and osteogenic differentiation.
Lamin B1 deficiency promotes malignancy and predicts poor prognosis in gastric cancer.
miR-5193, regulated by FUT1, suppresses proliferation and migration of ovarian cancer cells by targeting TRIM11.
Functionalized graphene oxide against U251 glioma cells and its molecular mechanism.
Comparison of the Effects of Nonprotein and Protein Nitrogen on Apoptosis and Autophagy of Rumen Epithelial Cells in Goats.
Design and synthesis of novel Flavone-based histone deacetylase inhibitors antagonizing activation of STAT3 in breast cancer.
Upregulation of mitochondrial E3 ubiquitin ligase 1 in rat heart contributes to ischemia/reperfusion injury.
ADAM12 silencing promotes cellular apoptosis by activating autophagy in choriocarcinoma cells.
Exogenous spermine attenuates rat diabetic cardiomyopathy via suppressing ROS-p53 mediated downregulation of calcium-sensitive receptor.
Palmatine induces G2/M phase arrest and mitochondrial-associated pathway apoptosis in colon cancer cells by targeting AURKA.
Naked mole-rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties.
Dietary supplementation of l-arginine and N-carbamylglutamate enhances duodenal barrier and mitochondrial functions and suppresses duodenal inflammation and mitophagy in suckling lambs suffering from intrauterine-growth-restriction.
ROS/p53/miR‑335‑5p/Sp1 axis modulates the migration and epithelial to mesenchymal transition of JEG‑3 cells.
Ubiquitination of P53 by E3 ligase MKRN2 promotes melanoma cell proliferation.
BRD4 inhibition exerts anti-viral activity through DNA damage-dependent innate immune responses.
Multiple inflammatory profiles of microglia and altered neuroimages in APP/PS1 transgenic AD mice.
G protein-coupled receptor kinase-2: A potential biomarker for early diabetic cardiomyopathy.
Novel HSP90-PI3K Dual Inhibitor Suppresses Melanoma Cell Proliferation by Interfering with HSP90-EGFR Interaction and Downstream Signaling Pathways.
Association of the Polymorphism rs13259960 in SLEAR With Predisposition to Systemic Lupus Erythematosus.
Triptolide interrupts rRNA synthesis and induces the RPL23‑MDM2‑p53 pathway to repress lung cancer cells.
All-trans retinoic acid enhances the effect of Fra-1 to inhibit cell proliferation and metabolism in cervical cancer.
In vitro and in vivo growth inhibition of human cervical cancer cells via human papillomavirus E6/E7 mRNAs' cleavage by CRISPR/Cas13a system.
Oxidative stress induces monocyte-to-myofibroblast transdifferentiation through p38 in pancreatic ductal adenocarcinoma.
Radiation-Induced DNMT3B Promotes Radioresistance in Nasopharyngeal Carcinoma through Methylation of p53 and p21.
Neurotoxicity of aluminum oxide nanoparticles and their mechanistic role in dopaminergic neuron injury involving p53-related pathways.
MeCP2 facilitates breast cancer growth via promoting ubiquitination-mediated P53 degradation by inhibiting RPL5/RPL11 transcription.
10-Hydroxydecanoic acid inhibits LPS-induced inflammation by targeting p53 in microglial cells.
Downregulation of circular RNA circPVT1 restricts cell growth of hepatocellular carcinoma through downregulation of Sirtuin 7 via microRNA-3666.
Transcription factorIRX5 promotes hepatocellular carcinoma proliferation and inhibits apoptosis by regulating the p53 signalling pathway.
Toosendanin-induced apoptosis in colorectal cancer cells is associated with the κ-opioid receptor/β-catenin signaling axis.
Mutant p53 Drives Cancer Metastasis via RCP-Mediated Hsp90α Secretion.
Pyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3) signaling in cardiomyocytes are essential for myocardial fibrosis in response to pressure overload.
Curcumin-enhanced antitumor effects of sorafenib via regulating the metabolism and tumor microenvironment.
The E3 ubiquitin ligase UBR5 interacts with the H/ACA ribonucleoprotein complex and regulates ribosomal RNA biogenesis in embryonic stem cells.
Pentamidine inhibits prostate cancer progression via selectively inducing mitochondrial DNA depletion and dysfunction.
Withaferin A triggers G2/M arrest and intrinsic apoptosis in glioblastoma cells via ATF4-ATF3-CHOP axis.
Disulfiram/Copper Induces Antitumor Activity against Both Nasopharyngeal Cancer Cells and Cancer-Associated Fibroblasts through ROS/MAPK and Ferroptosis Pathways.
Cooperation of SRPK2, Numb and p53 in the malignant biology and chemosensitivity of colorectal cancer.
Inhibition of long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 attenuates high glucose-induced cardiomyocyte apoptosis via regulation of miR-181a-5p.
Apoptotic Effect of 1800 MHz Electromagnetic Radiation on NIH/3T3 Cells.
Liver changes induced by cadmium poisoning distinguished by confocal Raman imaging.
RETRACTED: Endogenous production of C-C motif chemokine ligand 2 by nasopharyngeal carcinoma cells drives radioresistance-associated metastasis.
Novel, genetically induced mouse model that recapitulates the histological morphology and immunosuppressive tumor microenvironment of metastatic peritoneal carcinomatosis.
NAMPT maintains mitochondria content via NRF2-PPARα/AMPKα pathway to promote cell survival under oxidative stress.
Tumor suppressor LHPP regulates the proliferation of colorectal cancer cells via the PI3K/AKT pathway.
GRWD1 promotes cell proliferation and migration in non-small cell lung cancer by activating the Notch pathway.
Disruption of the Keap1/Nrf2-Antioxidant Response System After Chronic Doxorubicin Exposure In Vivo.
High expression of RRM2 as an independent predictive factor of poor prognosis in patients with lung adenocarcinoma.
Inhibitor of growth 2 regulates the high glucose-induced cell cycle arrest and epithelial-to-mesenchymal transition in renal proximal tubular cells.
Exopolysaccharide from Cryptococcus heimaeyensis S20 induces autophagic cell death in non-small cell lung cancer cells via ROS/p38 and ROS/ERK signalling.
TP53 mutation influences the efficacy of treatment of colorectal cancer cell lines with a combination of sirtuin inhibitors and chemotherapeutic agents.
miR-106a Regulates Cell Proliferation and Autophagy by Targeting LKB1 in HPV-16-Associated Cervical Cancer.
Ginsenoside Rh4 suppresses aerobic glycolysis and the expression of PD-L1 via targeting AKT in esophageal cancer.
BCCIPβ facilitates p53 ubiquitination via binding with E6 protein in high-risk HPV positive head and neck squamous cell carcinoma.
Caloric restriction alleviates aging-related fibrosis of kidney through downregulation of miR-21 in extracellular vesicles.
Synergistic effects of tanshinone IIA and andrographolide on the apoptosis of cancer cells via crosstalk between p53 and reactive oxygen species pathways.
COX-2/sEH dual inhibitor PTUPB alleviates bleomycin-induced pulmonary fibrosis in mice via inhibiting senescence.
N(6)-methyladenosine mediates arsenite-induced human keratinocyte transformation by suppressing p53 activation.
Effects of selenium on the proliferation and apoptosis of sheep spermatogonial stem cells in vitro.
Cyanidin-3-O-glucoside restores spermatogenic dysfunction in cadmium-exposed pubertal mice via histone ubiquitination and mitigating oxidative damage.
A bicyclic pentapeptide-based highly potent and selective pan-SIRT1/2/3 inhibitor harboring N(ε)-thioacetyl-lysine.
MicroRNA-16 participates in the cell cycle alteration of HepG2 cells induced by MC-LR.
Genome-scale CRISPR activation screening identifies a role of ELAVL2-CDKN1A axis in paclitaxel resistance in esophageal squamous cell carcinoma.
Hypoxia-induced feedback of HIF-1α and lncRNA-CF129 contributes to pancreatic cancer progression through stabilization of p53 protein.
Novel Breast-Specific Long Non-coding RNA LINC00993 Acts as a Tumor Suppressor in Triple-Negative Breast Cancer.
Long Non-coding RNA SNHG12 Functions as a Competing Endogenous RNA to Regulate MDM4 Expression by Sponging miR-129-5p in Clear Cell Renal Cell Carcinoma.
miR-4521-FAM129A axial regulation on ccRCC progression through TIMP-1/MMP2/MMP9 and MDM2/p53/Bcl2/Bax pathways.
LncRNA ZFAS1 promotes proliferation and migration and inhibits apoptosis in nasopharyngeal carcinoma via the PI3K/AKT pathway in vitro.
2-Methoxy-5((3,4,5-trimethosyphenyl)seleninyl) phenol reverses EGF-induced cell migration and invasion through down-regulation of MDM2 in breast cancer cell lines.
MDM2 inhibitor RG7388 potently inhibits tumors by activating p53 pathway in nasopharyngeal carcinoma.
SSRP1 influences colorectal cancer cell growth and apoptosis via the AKT pathway.
The ginsenoside Rk3 exerts anti-esophageal cancer activity in vitro and in vivo by mediating apoptosis and autophagy through regulation of the PI3K/Akt/mTOR pathway.
Synergism of cisplatin-oleanolic acid co-loaded calcium carbonate nanoparticles on hepatocellular carcinoma cells for enhanced apoptosis and reduced hepatotoxicity.
RAD6B Plays a Critical Role in Neuronal DNA Damage Response to Resist Neurodegeneration.
Hypermethylation Of ADHFE1 Promotes The Proliferation Of Colorectal Cancer Cell Via Modulating Cell Cycle Progression.
SIRT6 promotes the Warburg effect of papillary thyroid cancer cell BCPAP through reactive oxygen species.
6-Bromoindirubin-3'-Oxime (6BIO) Suppresses the mTOR Pathway, Promotes Autophagy, and Exerts Anti-aging Effects in Rodent Liver.
Ubiquitination of the HPV Oncoprotein E6 Is Critical for E6/E6AP-Mediated p53 Degradation.
Protective Effects of Dioscin Against Doxorubicin-Induced Hepatotoxicity Via Regulation of Sirt1/FOXO1/NF-κb Signal.
Hydrogen inhalation protects hypoxic-ischemic brain damage by attenuating inflammation and apoptosis in neonatal rats.
Functional daidzein enhances the anticancer effect of topotecan and reverses BCRP-mediated drug resistance in breast cancer.
Parthenolide regulates oxidative stress-induced mitophagy and suppresses apoptosis through p53 signaling pathway in C2C12 myoblasts.
XAB2 depletion induces intron retention in POLR2A to impair global transcription and promote cellular senescence.
Partially Hydrolyzed Guar Gum Attenuates d-Galactose-Induced Oxidative Stress and Restores Gut Microbiota in Rats.
Long non-coding RNA HOTAIR modulates intervertebral disc degenerative changes via Wnt/β-catenin pathway.
RNA-binding protein CELF6 is cell cycle regulated and controls cancer cell proliferation by stabilizing p21.
Design, synthesis, antitumor activities and biological studies of novel diaryl substituted fused heterocycles as dual ligands targeting tubulin and katanin.
miR-146a attenuates apoptosis and modulates autophagy by targeting TAF9b/P53 pathway in doxorubicin-induced cardiotoxicity.
Dexmedetomidine protects hippocampal neurons against hypoxia/reoxygenation-induced apoptosis through activation HIF-1α/p53 signaling.
Rice protein reduces DNA damage by activating the p53 pathway and stimulating endogenous antioxidant response in growing and adult rats.
Knockdown of RNF2 enhances the radiosensitivity of squamous cell carcinoma in lung.
Cyclin-dependent kinase 1 disruption inhibits angiogenesis by inducing cell cycle arrest and apoptosis.
Semaphorin 4C Promotes Macrophage Recruitment and Angiogenesis in Breast Cancer.
RNA sequencing analysis of the CAL-27 cell response to over-expressed ZNF750 gene revealed an extensive regulation on cell cycle.
Anti-ageing and antioxidant effects of sulfate oligosaccharides from green algae Ulva lactuca and Enteromorpha prolifera in SAMP8 mice.
NEDD4 protects vascular endothelial cells against Angiotensin II-induced cell death via enhancement of XPO1-mediated nuclear export.
Dehydrogenase/reductase SDR family member 2 silencing sensitizes an oxaliplatin‑resistant cell line to oxaliplatin by inhibiting excision repair cross‑complementing group 1 protein expression.
Niban protein regulates apoptosis in HK-2 cells via caspase-dependent pathway.
Sulforaphane Mediates Glutathione Depletion via Polymeric Nanoparticles to Restore Cisplatin Chemosensitivity.
Folic acid delays age-related cognitive decline in senescence-accelerated mouse prone 8: alleviating telomere attrition as a potential mechanism.
CD105 Is Expressed in Ovarian Cancer Precursor Lesions and Is Required for Metastasis to the Ovary.
Serine/arginine protein-specific kinase 2 promotes the development and progression of pancreatic cancer by downregulating Numb and p53.
Establishment and characterization of a radiation-induced dermatitis rat model.
Fuplatin: An Efficient and Low-Toxic Dual-Prodrug.
miR-340-FHL2 axis inhibits cell growth and metastasis in ovarian cancer.
Cloxiquine, a traditional antituberculosis agent, suppresses the growth and metastasis of melanoma cells through activation of PPARγ.
CircRNA_014511 affects the radiosensitivity of bone marrow mesenchymal stem cells by binding to miR-29b-2-5p.
Retinoic Acid-Related Orphan Receptor C Regulates Proliferation, Glycolysis, and Chemoresistance via the PD-L1/ITGB6/STAT3 Signaling Axis in Bladder Cancer.
Avenanthramide A Induces Cellular Senescence via miR-129-3p/Pirh2/p53 Signaling Pathway To Suppress Colon Cancer Growth.
Anterior Gradient-2 monoclonal antibody inhibits lung cancer growth and metastasis by upregulating p53 pathway and without exerting any toxicological effects: A preclinical study.
p53/Lactate dehydrogenase A axis negatively regulates aerobic glycolysis and tumor progression in breast cancer expressing wild-type p53.
TZAP plays an inhibitory role in the self-renewal of porcine mesenchymal stromal cells and is implicated the regulation of premature senescence via the p53 pathway.
SIRT1 suppresses p53-dependent apoptosis by modulation of p21 in osteoblast-like MC3T3-E1 cells exposed to fluoride.
ERβ modulates genistein's cisplatin-enhancing activities in breast cancer MDA-MB-231 cells via P53-independent pathway.
The p53/miRNAs/Ccna2 pathway serves as a novel regulator of cellular senescence: Complement of the canonical p53/p21 pathway.
Insulin-like growth factor-1 attenuates oxidative stress-induced hepatocyte premature senescence in liver fibrogenesis via regulating nuclear p53-progerin interaction.
RNF128 Promotes Invasion and Metastasis Via the EGFR/MAPK/MMP-2 Pathway in Esophageal Squamous Cell Carcinoma.
Dihydromyricetin alleviates acetaminophen-induced liver injury via the regulation of transformation, lipid homeostasis, cell death and regeneration.
2,4-Disubstituted quinazolines targeting breast cancer cells via EGFR-PI3K.
Effects of palmatine hydrochloride mediated photodynamic therapy on oral squamous cell carcinoma.
Normoxia is not favorable for maintaining stemness of human endothelial progenitor cells.
NR2E3 is a key component in p53 activation by regulating a long noncoding RNA DINO in acute liver injuries.
Methionine restriction delays senescence and suppresses the senescence-associated secretory phenotype in the kidney through endogenous hydrogen sulfide.
Long non-coding RNA and mRNA profile analysis of metformin to reverse the pulmonary hypertension vascular remodeling induced by monocrotaline.
Regulatory factor X5 promotes hepatocellular carcinoma progression by transactivating tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta and suppressing apoptosis.
Melatonin prevents lung injury by regulating apelin 13 to improve mitochondrial dysfunction.
Discovery of N-phenyl-(2,4-dihydroxypyrimidine-5-sulfonamido) phenylurea-based thymidylate synthase (TS) inhibitor as a novel multi-effects antitumor drugs with minimal toxicity.
ERp57‑small interfering RNA silencing can enhance the sensitivity of drug‑resistant human ovarian cancer cells to paclitaxel.
Apoptosis induced by ursodeoxycholic acid in human melanoma cells through the mitochondrial pathway.
Heme oxygenase-1 prevents heart against myocardial infarction by attenuating ischemic injury-induced cardiomyocytes senescence.
Estrogen receptor variant ER-α36 promotes tamoxifen agonist activity in glioblastoma cells.
Intracellular NO-Generator Based on Enzyme Trigger for Localized Tumor-Cytoplasm Rapid Drug Release and Synergetic Cancer Therapy.
Genome-Wide Profiling of Cervical RNA-Binding Proteins Identifies Human Papillomavirus Regulation of RNASEH2A Expression by Viral E7 and E2F1.
A phenanthroline derivative enhances radiosensitivity of hepatocellular carcinoma cells by inducing mitochondria-dependent apoptosis.
The Roles of HK2 on Tumorigenesis of Cervical Cancer.
Down-regulation of lncRNA OGFRP1 induces autophagy and growth inhibition by AKT/mTOR signaling pathway in HCAECs.
Ubiquinol-cytochrome C reductase core protein II promotes tumorigenesis by facilitating p53 degradation.
PPPDE1 promotes hepatocellular carcinoma development by negatively regulate p53 and apoptosis.
Discovery of a small molecule targeting autophagy via ATG4B inhibition and cell death of colorectal cancer cells in vitro and in vivo.
Scutellarin synergistically enhances cisplatin effect against ovarian cancer cells through enhancing the ability of cisplatin binding to DNA.
MiR-223-3p functions as a tumor suppressor in lung squamous cell carcinoma by miR-223-3p-mutant p53 regulatory feedback loop.
DRAM2 acts as an oncogene in non-small cell lung cancer and suppresses the expression of p53.
P53-induced miR-1249 inhibits tumor growth, metastasis, and angiogenesis by targeting VEGFA and HMGA2.
Dexmedetomidine attenuates lipopolysaccharide-induced liver oxidative stress and cell apoptosis in rats by increasing GSK-3β/MKP-1/Nrf2 pathway activity via the α2 adrenergic receptor.
Pifithrin-α enhancing anticancer effect of topotecan on p53-expressing cancer cells.
Design, synthesis and molecular mechanisms of novel dual inhibitors of heat shock protein 90/phosphoinositide 3-kinase alpha (Hsp90/PI3Kα) against cutaneous melanoma.
Shikonin exerts antitumor activity by causing mitochondrial dysfunction in hepatocellular carcinoma through PKM2-AMPK-PGC1α signaling pathway.
Visfatin Plays a Significant Role in Alleviating Lipopolysaccharide-Induced Apoptosis and Autophagy Through PI3K/AKT Signaling Pathway During Acute Lung Injury in Mice.
Stepwise detection and evaluation reveal miR-10b and miR-222 as a remarkable prognostic pair for glioblastoma.
XRCC4, which is inhibited by PFDA, regulates DNA damage repair and cell chemosensitivity.
Sinoporphyrin sodium based sonodynamic therapy induces anti-tumor effects in hepatocellular carcinoma and activates p53/caspase 3 axis.
Jingfukang induces anti-cancer activity through oxidative stress-mediated DNA damage in circulating human lung cancer cells.
Interferon regulatory factor-1 reverses chemoresistance by downregulating the expression of P-glycoprotein in gastric cancer.
Nicotinamide phosphoribosyl transferase regulates cell growth via the Sirt1/P53 signaling pathway and is a prognosis marker in colorectal cancer.
Combination of dihydromyricetin and ondansetron strengthens antiproliferative efficiency of adriamycin in K562/ADR through downregulation of SORCIN: A new strategy of inhibiting P-glycoprotein.
Potent effects of dioscin against hepatocellular carcinoma through regulating TP53-induced glycolysis and apoptosis regulator (TIGAR)-mediated apoptosis, autophagy, and DNA damage.
Citrus alkaline extracts prevent fibroblast senescence to ameliorate pulmonary fibrosis via activation of COX-2.
Renoprotective effect of scutellarin on cisplatin-induced renal injury in mice: Impact on inflammation, apoptosis, and autophagy.
GTSE1 is involved in breast cancer progression in p53 mutation-dependent manner.
YAP Aggravates Inflammatory Bowel Disease by Regulating M1/M2 Macrophage Polarization and Gut Microbial Homeostasis.
Fangchinoline Ameliorates the Expressions of Angiogenic Molecule in Cerebral Ischemia Induced Neuronal Degeneration in Neonatal Rats.
N-Cadherin Attenuates High Glucose-Induced Nucleus Pulposus Cell Senescence Through Regulation of the ROS/NF-κB Pathway.
Long non-coding RNA MT1DP shunts the cellular defense to cytotoxicity through crosstalk with MT1H and RhoC in cadmium stress.
SS-31 Provides Neuroprotection by Reversing Mitochondrial Dysfunction after Traumatic Brain Injury.
Activating the PGC-1α/TERT Pathway by Catalpol Ameliorates Atherosclerosis via Modulating ROS Production, DNA Damage, and Telomere Function: Implications on Mitochondria and Telomere Link.
Realgar, a traditional Chinese medicine, induces apoptosis of HPV16-positive cervical cells through a HPV16 E7-related pathway.
Baicalin Protects Mice Brain From Apoptosis in Traumatic Brain Injury Model Through Activation of Autophagy.
Inhibition of survivin enhances radiosensitivity of esophageal cancer cells by switching radiation-induced senescence to apoptosis.
Aloperine executes antitumor effects through the induction of apoptosis and cell cycle arrest in prostate cancer in vitro and in vivo.
S100B promotes chemoresistance in ovarian cancer stem cells by regulating p53.
Study on the potential way of hepatic cytotoxicity of N,N-dimethylformamide.
Protective effect and mechanism of rat recombinant S100 calcium-binding protein A4 on oxidative stress injury of rat vascular endothelial cells.
Rapid induction of apoptosis in tumor cells treated with a new platinum(II) complex based on amino-thiazolidinone.
Nogo-B receptor increases the resistance to tamoxifen in estrogen receptor-positive breast cancer cells.
Novel role of PKR in palmitate-induced Sirt1 inactivation and endothelial cell senescence.
UVB-inhibited H19 activates melanogenesis by paracrine effects.
Dachshund 1 is Differentially Expressed Between Male and Female Breast Cancer: A Matched Case-Control Study of Clinical Characteristics and Prognosis.
Effects of zerumbone on proliferation and apoptosis of esophageal cancer cells and on P53 and Bcl-2 expression levels.
Study on the expression of p53 and MMP-2 in patients with lung cancer after interventional therapy.
The oncoprotein HBXIP promotes human breast cancer growth through down-regulating p53 via miR-18b/MDM2 and pAKT/MDM2 pathways.
Protocatechuic acid inhibits the growth of ovarian cancer cells by inducing apoptosis and autophagy.
Insight into the negative impact of ionic liquid: A cytotoxicity mechanism of 1-methyl-3-octylimidazolium bromide.
A biobank of patient-derived pediatric brain tumor models.
Inhibin B suppresses anoikis resistance and migration through the transforming growth factor-β signaling pathway in nasopharyngeal carcinoma.
Synergetic and Antagonistic Molecular Effects Mediated by the Feedback Loop of p53 and JNK between Saikosaponin D and SP600125 on Lung Cancer A549 Cells.
Radiation-induced premature cellular senescence involved in glomerular diseases in rats.
Comparative characterization of SHED and DPSCs during extended cultivation in vitro.
Ginsenoside Rg1 ameliorates testicular senescence changes in D‑gal‑induced aging mice via anti‑inflammatory and antioxidative mechanisms.
Procyanidin from peanut skin induces antiproliferative effect in human prostate carcinoma cells DU145.
Metformin-induced activation of AMPK inhibits the proliferation and migration of human aortic smooth muscle cells through upregulation of p53 and IFI16.
AATF suppresses apoptosis, promotes proliferation and is critical for Kras-driven lung cancer.
Hematopoietic Substrate-1-Associated Protein X-1 Regulates the Proliferation and Apoptosis of Endothelial Progenitor Cells Through Akt Pathway Modulation.
Oxidative stress-mediated p53/p21(WAF1/CIP1) pathway may be involved in microcystin-LR-induced cytotoxicity in HepG2 cells.
Potent hydrazone derivatives targeting esophageal cancer cells.
Epidermal Growth Factor, through Alleviating Oxidative Stress, Protect IPEC-J2 Cells from Lipopolysaccharides-Induced Apoptosis.
Effects of three-dimensional collagen scaffolds on the expression profiles and biological functions of glioma cells.
Atrazine exposure improves the proliferation of H22 cells in vitro and in vivo.
3-O-acetyl-11-keto-β-boswellic acid exerts anti-tumor effects in glioblastoma by arresting cell cycle at G2/M phase.
Heme oxygenase-1 ameliorates oxidative stress-induced endothelial senescence via regulating endothelial nitric oxide synthase activation and coupling.
Tripartite motif 31 promotes resistance to anoikis of hepatocarcinoma cells through regulation of p53-AMPK axis.
Dietary restriction delays the secretion of senescence associated secretory phenotype by reducing DNA damage response in the process of renal aging.
Triggering p53 activation is essential in ziyuglycoside I-induced human retinoblastoma WERI-Rb-1 cell apoptosis.
Downregulation of TRIM28 inhibits growth and increases apoptosis of nude mice with non‑small cell lung cancer xenografts.
Atorvastatin exerts inhibitory effect on endothelial senescence in hyperlipidemic rats through a mechanism involving down-regulation of miR-21-5p/203a-3p.
Experimental evidence of good efficacy and reduced toxicity with peptide-doxorubicin to treat gastric cancer.
PLZF inhibits proliferation and metastasis of gallbladder cancer by regulating IFIT2.
Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral β-lactam bridged combretastatin A-4 analogues as potent antitumor agents.
The Potential Roles of the Apoptosis-Related Protein PDRG1 in Diapause Embryo Restarting of Artemia sinica.
High expression of TMEM40 is associated with the malignant behavior and tumorigenesis in bladder cancer.
Inhibition of neddylation by MLN4924 improves neointimal hyperplasia and promotes apoptosis of vascular smooth muscle cells through p53 and p62.
N‑cadherin attenuates nucleus pulposus cell senescence under high‑magnitude compression.
SIRT3 deacetylates and promotes degradation of P53 in PTEN-defective non-small cell lung cancer.
Upregulation of the ALDOA/DNA-PK/p53 pathway by dietary restriction suppresses tumor growth.
Clinorotation-induced autophagy via HDM2-p53-mTOR pathway enhances cell migration in vascular endothelial cells.
NIT1 suppresses tumour proliferation by activating the TGFβ1-Smad2/3 signalling pathway in colorectal cancer.
MYL6B, a myosin light chain, promotes MDM2-mediated p53 degradation and drives HCC development.
mTORC2 facilitates endothelial cell senescence by suppressing Nrf2 expression via the Akt/GSK-3β/C/EBPα signaling pathway.
PTBP3 splicing factor promotes hepatocellular carcinoma by destroying the splicing balance of NEAT1 and pre-miR-612.
1,3-Dichloro-2-Propanol inhibits autophagy via P53/AMPK/mTOR pathway in HepG2 cells.
Urea transport B gene induces melanoma B16 cell death via activation of p53 and mitochondrial apoptosis.
Xin-Jia-Xiang-Ru-Yin alleviated H1N1-induced acute lung injury and inhibited the IFN-γ-related regulatory pathway in summer flu.
Long non-coding RNA GClnc1 promotes tumorigenesis in osteosarcoma by inhibiting p53 signaling.
Activation of p53 by costunolide blocks glutaminolysis and inhibits proliferation in human colorectal cancer cells.
Synthesis and Discovery Novel Anti-Cancer Stem Cells Compounds Derived from the Natural Triterpenoic Acids.
Overexpression of FOXQ1 enhances anti-senescence and migration effects of human umbilical cord mesenchymal stem cells in vitro and in vivo.
DNA damage triggers tubular endoplasmic reticulum extension to promote apoptosis by facilitating ER-mitochondria signaling.
Protective role of fenofibrate in sepsis-induced acute kidney injury in BALB/c mice.
A novel Anti-Cancer Stem Cells compound optimized from the natural symplostatin 4 scaffold inhibits Wnt/β-catenin signaling pathway.
Nucleus pulposus cell senescence is alleviated by resveratrol through regulating the ROS/NF-κB pathway under high-magnitude compression.
Fenofibrate Exerts Protective Effects in Diabetic Retinopathy via Inhibition of the ANGPTL3 Pathway.
Traditional Chinese Medicine CFF-1 induced cell growth inhibition, autophagy, and apoptosis via inhibiting EGFR-related pathways in prostate cancer.
Anticancer activity and potential mechanisms of 1C, a ginseng saponin derivative, on prostate cancer cells.
Targeting P-glycoprotein and SORCIN: Dihydromyricetin strengthens anti-proliferative efficiency of adriamycin via MAPK/ERK and Ca(2+) -mediated apoptosis pathways in MCF-7/ADR and K562/ADR.
The enhancement of siPLK1 penetration across BBB and its anti glioblastoma activity in vivo by magnet and transferrin co-modified nanoparticle.
Knockdown of long noncoding RNA MEG3 impairs VEGF-stimulated endothelial sprouting angiogenesis via modulating VEGFR2 expression in human umbilical vein endothelial cells.
MicroRNA-326 sensitizes human glioblastoma cells to curcumin via the SHH/GLI1 signaling pathway.
Thymoquinone protects against cardiac damage from doxorubicin-induced heart failure in Sprague-Dawley rats.
Nogo-B receptor increases the resistance of estrogen receptor positive breast cancer to paclitaxel.
Berberine Enhances Chemosensitivity and Induces Apoptosis Through Dose-orchestrated AMPK Signaling in Breast Cancer.
H(2)S Donor NaHS Changes the Production of Endogenous H(2)S and NO in D-Galactose-Induced Accelerated Ageing.
Berberine Reverses Hypoxia-induced Chemoresistance in Breast Cancer through the Inhibition of AMPK- HIF-1α.
Lyophilized Powder of Catalpol and Puerarin Protected Cerebral Vessels from Ischemia by Its Anti-apoptosis on Endothelial Cells.
17beta-estradiol Attenuates TNF-α-Induced Premature Senescence of Nucleus Pulposus Cells through Regulating the ROS/NF-κB Pathway.
HAX-1 Protects Glioblastoma Cells from Apoptosis through the Akt1 Pathway.
Inhibition effect of tacrolimus and platelet-derived growth factor-BB on restenosis after vascular intimal injury.
High-grade serous carcinomas arise in the mouse oviduct via defects linked to the human disease.
MDM2 Contributes to High Glucose-Induced Glomerular Mesangial Cell Proliferation and Extracellular Matrix Accumulation via Notch1.
2-Acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylcarbonylamino) phenyl carbamoylsulfanyl] propionic acid, a glutathione reductase inhibitor, induces G(2)/M cell cycle arrest through generation of thiol oxidative stress in human esophageal cancer cells.
ATM-deficiency increases genomic instability and metastatic potential in a mouse model of pancreatic cancer.
Misidentified Human Gene Functions with Mouse Models: The Case of the Retinoblastoma Gene Family in Senescence.
HSF4 regulates lens fiber cell differentiation by activating p53 and its downstream regulators.
Florfenicol-induced Mitochondrial Dysfunction Suppresses Cell Proliferation and Autophagy in Fibroblasts.
Insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) promotes lung tumorigenesis via attenuating p53 stability.
Core 3 mucin-type O-glycan restoration in colorectal cancer cells promotes MUC1/p53/miR-200c-dependent epithelial identity.
Oridonin induces G2/M cell cycle arrest and apoptosis in human oral squamous cell carcinoma.
Quercetin exerts synergetic anti-cancer activity with 10-hydroxy camptothecin.
Tributylphosphate (TBP) and tris (2-butoxyethyl) phosphate (TBEP) induced apoptosis and cell cycle arrest in HepG2 cells.
TRPC5 channel modulates endothelial cells senescence.
Vascular endothelial cells senescence is associated with NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation via reactive oxygen species (ROS)/thioredoxin-interacting protein (TXNIP) pathway.
Therapeutic Targeting of RNA Polymerase I With the Small-Molecule CX-5461 for Prevention of Arterial Injury-Induced Neointimal Hyperplasia.
12-Chloracetyl-PPD, a novel dammarane derivative, shows anti-cancer activity via delay the progression of cell cycle G2/M phase and reactive oxygen species-mediate cell apoptosis.
Y14 governs p53 expression and modulates DNA damage sensitivity.
Cytotoxic effects of docetaxel as a candidate drug of drug-eluting stent on human umbilical vein endothelial cells and the signaling pathway of cell migration inhibition, adhesion delay and shape change.
miR-21-5p/203a-3p promote ox-LDL-induced endothelial cell senescence through down-regulation of mitochondrial fission protein Drp1.
Renal cell carcinoma with synchronous ipsilateral urothelial carcinoma of the renal pelvis.
Adiponectin modulates oxidative stress-induced mitophagy and protects C2C12 myoblasts against apoptosis.
Arginine deiminase expressed in vivo, driven by human telomerase reverse transcriptase promoter, displays high hepatoma targeting and oncolytic efficiency.
Homoharringtonine suppresses imatinib resistance via the Bcl-6/p53 pathway in chronic myeloid leukemia cell lines.
Molecular characterization of breast cancer cell lines through multiple omic approaches.
0404 inhibits hepatocellular carcinoma through a p53/miR-34a/SIRT1 positive feedback loop.
Variant 2 of KIAA0101, antagonizing its oncogenic variant 1, might be a potential therapeutic strategy in hepatocellular carcinoma.
Anthocyanins from Black Chokeberry (Aroniamelanocarpa Elliot) Delayed Aging-Related Degenerative Changes of Brain.
Mitochondria-Associated Apoptosis in Human Melanoma Cells Induced by Cardanol Monoene from Cashew Nut Shell Liquid.
The synthetic antihyperlipidemic drug potassium piperate selectively kills breast cancer cells through inhibiting G1-S-phase transition and inducing apoptosis.
Nurr1 promotes intestinal regeneration after ischemia/reperfusion injury by inhibiting the expression of p21 (Waf1/Cip1).
Hypoxia-inducible factor-2α promotes hepatocyte apoptosis during cholestasis.
The role of the ATM/Chk/P53 pathway in mediating DNA damage in hand-foot syndrome induced by PLD.
Targeting P-glycoprotein function, p53 and energy metabolism: Combination of metformin and 2-deoxyglucose reverses the multidrug resistance of MCF-7/Dox cells to doxorubicin.
CRB3 regulates contact inhibition by activating the Hippo pathway in mammary epithelial cells.
ISG15 inhibits cancer cell growth and promotes apoptosis.
S100B Mediates Stemness of Ovarian Cancer Stem-Like Cells Through Inhibiting p53.
The inflammatory cytokine TNF-α promotes the premature senescence of rat nucleus pulposus cells via the PI3K/Akt signaling pathway.
Anthocyanins Delay Ageing-Related Degenerative Changes in the Liver.
The inflammatory responses in Cu-mediated elemental imbalance is associated with mitochondrial fission and intrinsic apoptosis in Gallus gallus heart.
Co‑expression of murine double minute 2 siRNA and wild‑type p53 induces G1 cell cycle arrest in H1299 cells.
Phloretin induces apoptosis of human esophageal cancer via a mitochondria-dependent pathway.
Bisphenol AF negatively affects oocyte maturation of mouse in vitro through increasing oxidative stress and DNA damage.
Design, synthesis, and biological evaluation of hydantoin bridged analogues of combretastatin A-4 as potential anticancer agents.
IGFBP-rP1 acts as a potential tumor suppressor via the suppression of ERK signaling pathway in endometrial cancer cells.
Anti-colon cancer effect of caffeic acid p-nitro-phenethyl ester in vitro and in vivo and detection of its metabolites.
Hsa-miR-513b-5p suppresses cell proliferation and promotes P53 expression by targeting IRF2 in testicular embryonal carcinoma cells.
Inflammatory factor TNF-α promotes the growth of breast cancer via the positive feedback loop of TNFR1/NF-κB (and/or p38)/p-STAT3/HBXIP/TNFR1.
Role of Epithelial Cell Transforming Sequence 2 (ECT2) in Predicting Prognosis of Osteosarcoma.
Downregulation of B-myb promotes senescence via the ROS-mediated p53/p21 pathway, in vascular endothelial cells.
Protective effect of naringin against the LPS-induced apoptosis of PC12 cells: Implications for the treatment of neurodegenerative disorders.
G protein subunit α q regulates gastric cancer growth via the p53/p21 and MEK/ERK pathways.
Nuclear retention of the lncRNA SNHG1 by doxorubicin attenuates hnRNPC-p53 protein interactions.
Boschniakia Rossica Polysaccharide Triggers Laryngeal Carcinoma Cell Apoptosis by Regulating Expression of Bcl-2, Caspase-3, and P53.
Effects of selenium on the proliferation, apoptosis and testosterone production of sheep Leydig cells in vitro.
Identification, expression pattern and functional characterization of As-kip2 in diapause embryo restarting process of Artemia sinica.
Co-expression of ING4 and P53 enhances hypopharyngeal cancer chemosensitivity to cisplatin in vivo.
The Growth of SGC-7901 Tumor Xenografts Was Suppressed by Chinese Bayberry Anthocyanin Extract through Upregulating KLF6 Gene Expression.
Novel Angiogenic Activity and Molecular Mechanisms of ZYZ-803, a Slow-Releasing Hydrogen Sulfide-Nitric Oxide Hybrid Molecule.
Lactobacillus rhamnosus induced epithelial cell apoptosis, ameliorates inflammation and prevents colon cancer development in an animal model.
A novel strategy of profiling the mechanism of herbal medicines by combining network pharmacology with plasma concentration determination and affinity constant measurement.
Age-associated up-regulation of EGR1 promotes granulosa cell apoptosis during follicle atresia in mice through the NF-κB pathway.
Overexpression of PKM2 promotes mitochondrial fusion through attenuated p53 stability.
Ziyuglycoside I Inhibits the Proliferation of MDA-MB-231 Breast Carcinoma Cells through Inducing p53-Mediated G2/M Cell Cycle Arrest and Intrinsic/Extrinsic Apoptosis.
Atrazine promotes RM1 prostate cancer cell proliferation by activating STAT3 signaling.
Dioscin suppresses human laryngeal cancer cells growth via induction of cell-cycle arrest and MAPK-mediated mitochondrial-derived apoptosis and inhibition of tumor invasion.
Dioscin Induces Apoptosis in Human Cervical Carcinoma HeLa and SiHa Cells through ROS-Mediated DNA Damage and the Mitochondrial Signaling Pathway.
miR-34a-5p Inhibition Alleviates Intestinal Ischemia/Reperfusion-Induced Reactive Oxygen Species Accumulation and Apoptosis via Activation of SIRT1 Signaling.
Upregulation of microRNA-22 contributes to myocardial ischemia-reperfusion injury by interfering with the mitochondrial function.
Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation.
Expression and prognostic role of ubiquitination factor E4B in primary hepatocellular carcinoma.
Expression of Hedgehog Signals and Growth Inhibition by Itraconazole in Endometrial Cancer.
Nogo-B receptor promotes the chemoresistance of human hepatocellular carcinoma via the ubiquitination of p53 protein.
Inhibitory effect of diosgenin on experimentally induced benign prostatic hyperplasia in rats.
H2O2 treatment or serum deprivation induces autophagy and apoptosis in naked mole-rat skin fibroblasts by inhibiting the PI3K/Akt signaling pathway.
Unpredicted Downregulation of RAD51 Suggests Genome Instability Induced by Tetrachlorobenzoquinone.
Combination of baicalein and 10-hydroxy camptothecin exerts remarkable synergetic anti-cancer effects.
Directional modification of chrysin for exerting apoptosis and enhancing significantly anti-cancer effects of 10-hydroxy camptothecin.
VNN1 promotes atherosclerosis progression in apoE-/- mice fed a high-fat/high-cholesterol diet.
Paper-based microreactor array for rapid screening of cell signaling cascades.
Modulation of cyclins and p53 in mesangial cell proliferation and apoptosis during Habu nephritis.
Bioinformatics analysis of proteomics profiles in senescent human primary proximal tubule epithelial cells.
Disruption of human papillomavirus 16 E6 gene by clustered regularly interspaced short palindromic repeat/Cas system in human cervical cancer cells.
TRIM59 Promotes the Proliferation and Migration of Non-Small Cell Lung Cancer Cells by Upregulating Cell Cycle Related Proteins.
Elevated GAPDH expression is associated with the proliferation and invasion of lung and esophageal squamous cell carcinomas.
p53 is required for metformin-induced growth inhibition, senescence and apoptosis in breast cancer cells.
The oncoprotein HBXIP promotes glucose metabolism reprogramming via downregulating SCO2 and PDHA1 in breast cancer.
The oncoprotein HBXIP modulates the feedback loop of MDM2/p53 to enhance the growth of breast cancer.
Down-Regulated NRSN2 Promotes Cell Proliferation and Survival Through PI3K/Akt/mTOR Pathway in Hepatocellular Carcinoma.
Protein kinase CK2α catalytic subunit is overexpressed and serves as an unfavorable prognostic marker in primary hepatocellular carcinoma.
Olaquindox induces DNA damage via the lysosomal and mitochondrial pathway involving ROS production and p53 activation in HEK293 cells.
Pseudolaric acid B inhibits proliferation in SW579 human thyroid squamous cell carcinoma.
Mucin 1 gene silencing inhibits the growth of SMMC-7721 human hepatoma cells through Bax-mediated mitochondrial and caspase-8-mediated death receptor apoptotic pathways.
A Critical Role for Cysteine 57 in the Biological Functions of Selenium Binding Protein-1.
Polychlorinated Biphenyl Quinone Metabolite Promotes p53-Dependent DNA Damage Checkpoint Activation, S-Phase Cycle Arrest and Extrinsic Apoptosis in Human Liver Hepatocellular Carcinoma HepG2 Cells.
RASSF10 suppresses hepatocellular carcinoma growth by activating P53 signaling and methylation of RASSF10 is a docetaxel resistant marker.
Synergistic anti-tumour effects of tetrandrine and chloroquine combination therapy in human cancer: a potential antagonistic role for p21.
Deficiency of monoclonal non-specific suppressor factor beta (MNSFB) promotes pregnancy loss in mice.
5-Aminolevulinic Acid-Mediated Sonodynamic Therapy Promotes Phenotypic Switching from Dedifferentiated to Differentiated Phenotype via Reactive Oxygen Species and p38 Mitogen-Activated Protein Kinase in Vascular Smooth Muscle Cells.
Flotillin-2 promotes metastasis of nasopharyngeal carcinoma by activating NF-κB and PI3K/Akt3 signaling pathways.
Polychlorinated biphenyl quinone induces oxidative DNA damage and repair responses: The activations of NHEJ, BER and NER via ATM-p53 signaling axis.
Tetrandrine induces G1/S cell cycle arrest through the ROS/Akt pathway in EOMA cells and inhibits angiogenesis in vivo.
TALEN-mediated targeting of HPV oncogenes ameliorates HPV-related cervical malignancy.
Enhanced anticancer activity of a protein phosphatase 2A inhibitor on chemotherapy and radiation in head and neck squamous cell carcinoma.
Expression profile of apoptotic and proliferative proteins in hypoxic HUVEC treated with statins.
RTEF-1 protects against oxidative damage induced by H2O2 in human umbilical vein endothelial cells through Klotho activation.
5-Aminolevulinic acid-mediated sonodynamic therapy induces anti-tumor effects in malignant melanoma via p53-miR-34a-Sirt1 axis.
HSF4 promotes G1/S arrest in human lens epithelial cells by stabilizing p53.
The effect of mesenchymal stem cells on the p53 methylation in irradiation-induced thymoma in C57BL/6 mice.
Identification of nestin as a urinary biomarker for acute kidney injury.
Dioscin attenuates hepatic ischemia-reperfusion injury in rats through inhibition of oxidative-nitrative stress, inflammation and apoptosis.
Elevated p53 expression levels correlate with tumor progression and poor prognosis in patients exhibiting esophageal squamous cell carcinoma.
Effects of the total saponins from Rosa laevigata Michx fruit against acetaminophen-induced liver damage in mice via induction of autophagy and suppression of inflammation and apoptosis.
Protective effects of dioscin against alcohol-induced liver injury.
Cancer stem-like cell characteristics induced by EB virus-encoded LMP1 contribute to radioresistance in nasopharyngeal carcinoma by suppressing the p53-mediated apoptosis pathway.
Probing the cell death signaling pathway of HepG2 cell line induced by copper-1,10-phenanthroline complex.
Downregulated protein O-fucosyl transferase 1 (Pofut1) expression exerts antiproliferative and antiadhesive effects on hepatocytes by inhibiting Notch signalling.
DDX3X regulates cell survival and cell cycle during mouse early embryonic development.
MiR-135a functions as a tumor suppressor in epithelial ovarian cancer and regulates HOXA10 expression.
TET1 exerts its tumor suppressor function by interacting with p53-EZH2 pathway in gastric cancer.
Bisphenol A induces oxidative stress-associated DNA damage in INS-1 cells.
Salvianolic acid B protects against acute ethanol-induced liver injury through SIRT1-mediated deacetylation of p53 in rats.
Interplay between the Notch and PI3K/Akt pathways in high glucose-induced podocyte apoptosis.
Potent effects of flavonoid-rich extract from Rosa laevigata Michx fruit against hydrogen peroxide-induced damage in PC12 cells via attenuation of oxidative stress, inflammation and apoptosis.
Differential effects of p53 on bystander phenotypes induced by gamma ray and high LET heavy ion radiation.
Protective effect of SIRT1 on toxicity of microglial-derived factors induced by LPS to PC12 cells via the p53-caspase-3-dependent apoptotic pathway.
Protective effect of flavonoid-rich extract from Rosa laevigata Michx on cerebral ischemia-reperfusion injury through suppression of apoptosis and inflammation.
Notch pathway is involved in high glucose-induced apoptosis in podocytes via Bcl-2 and p53 pathways.
Loss of microRNA-143/145 disturbs cellular growth and apoptosis of human epithelial cancers by impairing the MDM2-p53 feedback loop.
Protective effects of the total saponins from Rosa laevigata Michx fruit against carbon tetrachloride-induced acute liver injury in mice.
High level of COP1 expression is associated with poor prognosis in primary gastric cancer.
Alantolactone induces activation of apoptosis in human hepatoma cells.
Total flavonoids from Rosa Laevigata Michx fruit attenuates hydrogen peroxide induced injury in human umbilical vein endothelial cells.
Sensitive detection of intracellular sumoylation via SNAP tag-mediated translation and RNA polymerase-based amplification.
NF-κB, JNK and p53 pathways are involved in tubeimoside-1-induced apoptosis in HepG2 cells with oxidative stress and G₂/M cell cycle arrest.
Induction of apoptosis in hepatocellular carcinoma Smmc-7721 cells by vitamin K(2) is associated with p53 and independent of the intrinsic apoptotic pathway.
alpha-Bisabolol induces dose- and time-dependent apoptosis in HepG2 cells via a Fas- and mitochondrial-related pathway, involves p53 and NFkappaB.
MiR-145, a new regulator of the DNA fragmentation factor-45 (DFF45)-mediated apoptotic network.
Zhu Y, Xu W, Wan C, Deng B, Xie Y, Yang B, Jiang H, Zhang C
International journal of biological sciences 2026;22(4):2177-2195
International journal of biological sciences 2026;22(4):2177-2195
X-Box Binding Protein 1 Regulates Osteogenesis of Periodontal Ligament Cells During Aging by Modulating P53 Signaling Pathway.
Zheng Y, Zhai M, Bai X, Yu K, Li J, Zhang Z
Stem cells international 2026;2026:2846096
Stem cells international 2026;2026:2846096
Bioinformatic Identification and Preliminary Validation of TP53, TGFB1, and NFE2L2 as Potential Ferroptosis-Related Regulators in Pancreatic Adenocarcinoma.
Li S, Zhang C, Lv S, Zhang Z, Xu D, Xu T
Pharmacogenomics and personalized medicine 2026;19:562602
Pharmacogenomics and personalized medicine 2026;19:562602
Aging Inhibits Emergency Angiogenesis and Exacerbates Neuronal Damage by Downregulating DARS2.
Liu D, Weng M, Wang R, Fu W, Zhang L, Wang C, Liu M, Shen T, Ren J, Song Y, Li J, Zeng X
Journal of inflammation research 2026;19:527147
Journal of inflammation research 2026;19:527147
Actinidia chinensis Planch Root extracts trigger ferroptosis in colorectal cancer via the p53/SLC7A11/GPX4 axis.
Ma C, Chen R, Wang H, Qiu K, Xia Q, Yang S, Wang J, Cheng Z, Cui W, Lu J, Duan S
Frontiers in pharmacology 2026;17:1724983
Frontiers in pharmacology 2026;17:1724983
UBE2W promotes pancreatic cancer progression through regulating K63-linked ubiquitination of p53.
Wei QY, Li XJ, Yong T, Gao TY, Ma JX, Zhang DY, Wei XX, Fan Y, Zhang YC
American journal of cancer research 2026;16(1):28-50
American journal of cancer research 2026;16(1):28-50
Tumor Prostate-Specific Antigen Density Can Predict Tumor Aggressiveness and Heterogeneity in Prostate Cancer.
Yang T, Wang X, Deng Y, Liu H, Chen Y, Zhao J, Huang Y, Liu S, Cao M, Zhang Q, Wang X, Xu H, Wu D, Zhuo H
The Prostate 2026 May;86(7):821-830
The Prostate 2026 May;86(7):821-830
Longitudinal prediction of drug response in high-grade serous ovarian cancer organoid cultures aligning with clinical responses.
Cavarzerani E, Caligiuri I, Bartoletti M, Corona G, Perin T, Palumbo A, Ditto A, Occhiali T, Canzonieri V, Rizzolio F
Journal of advanced research 2026 May;83:379-390
Journal of advanced research 2026 May;83:379-390
On-demand mild photothermal cascade platform reprogramming mitochondrial immunity for tendon rejuvenation.
Zheng Z, Hu Y, Zhu Y, Zhang H, Yang M, Ding G, Wu Y, Yang F, Lu B, Zhou Z, Liu X, Zhang G, Zhang X, Zhang D, Wang J, Huang H
Bioactive materials 2026 May;59:642-661
Bioactive materials 2026 May;59:642-661
Periplogenin Suppresses Hepatocarcinogenesis by Inducing Cellular Senescence via the Activating FOXO1/P53 Signaling Pathway.
Wang P, Zhu J, Li W, He Z, Dai X, Shi Y, Xu Z, Wang P, Wang R, Chen J, Liang R, Huang J, Jiang Y, Chen G, Chen H, Xie X
Phytotherapy research : PTR 2026 May;40(5):2588-2603
Phytotherapy research : PTR 2026 May;40(5):2588-2603
Characteristics of chromosomal instability‑related lncRNAs associated with progression and prognosis in breast cancer.
Chen Q, Chen H, Yang H, Tao Y, Zhu X
Molecular medicine reports 2026 May;33(5)
Molecular medicine reports 2026 May;33(5)
Integrating network toxicology and experimental validation to elucidate the molecular mechanism basis of chondrotoxicity of Benzo[a]pyrene in osteoarthritis.
Pan J, Zhang Z, Ma Y, Gao Y, Wang Z, Ma J, Wang X
Ecotoxicology and environmental safety 2026 May;316:120177
Ecotoxicology and environmental safety 2026 May;316:120177
Cinnamyl Alcohol Attenuates Osteoarthritis Progression via PIGR-Mediated Regulation of Chondrocyte Senescence and Cartilage Homeostasis.
Zhu Q, You Q, Deng J, Tang H, Hu Y, Liao Y, Miao Y
Journal of medicinal food 2026 May;29(5):279-293
Journal of medicinal food 2026 May;29(5):279-293
Dihydroartemisinin-Loaded ZIF-8 Nanoparticles Elicit Chemo-Immunotherapy against Malignant Pleural Effusion via Inhibition of OCT4/M-CSF Signaling Pathway.
You H, Li LG, Xiao CY, Wang X, Kong C, Leng F, Bai XF, Han N, Li TF, Wang MF
Molecular pharmaceutics 2026 May 4;23(5):3131-3145
Molecular pharmaceutics 2026 May 4;23(5):3131-3145
Small molecule HCY-NBD stabilizes GSTM2 via cys174 sulfenylation to attenuate high glucose induced endothelial cell senescence and calcification.
Zhang Y, Dong X, Yan X, Zhao C, Chi X, Zhao B, Miao J, Hong F, Lin Z
Redox biology 2026 Mar;90:104058
Redox biology 2026 Mar;90:104058
Prenylterphenyllin, a regulator of P53, inhibits colorectal cancer progression through oxidative stress and energy metabolism pathway.
Zhang Y, Han Y, Li S, Shan R, Lin L, Gu Z, Wang R, Chen Y, Xiao J, An F, Hu C, He C
Redox biology 2026 Mar;90:103993
Redox biology 2026 Mar;90:103993
Role of ITIH4 in Modulating YAP/TAZ-Mediated Apoptosis of Type II Alveolar Epithelium during Acute Respiratory Distress Syndrome.
Shih YS, Chen XY, Lin YW, Liao ZA, Liu YH, Laiman V, Peng SW, Ito K, Chuang HC
Pharmaceutical research 2026 Mar;43(3):619-633
Pharmaceutical research 2026 Mar;43(3):619-633
Hypoxia-preconditioned bone marrow mesenchymal stem cell-derived exosomes ameliorate knee osteoarthritis by promoting cartilage regeneration and alleviating pain in rats.
Zhang B, Lu C, Dou B, Gu W, Li K
Regenerative therapy 2026 Mar;31:101049
Regenerative therapy 2026 Mar;31:101049
The anti-aging drug Senolytics alleviates vascular endothelial cell senescence by antagonizing the JPX-BRD4-p65 complex.
Mao K, Zhu W, Sun H, Zheng H, Fu Z
Cellular signalling 2026 Mar;139:112342
Cellular signalling 2026 Mar;139:112342
YTHDF3-TRIM2-P53 axis promotes malignant progression in uveal melanoma (UVM).
Li H, Chen Y, Chen W, Li D, Hao R, Zhang W
Cellular signalling 2026 Mar;139:112316
Cellular signalling 2026 Mar;139:112316
Neddylation Targets and Stabilizes NLRP3 to Augment Inflammasome-Mediated Colitis and Mood Disorder.
Gai W, Wu M, Wu A, Jing Z, Ye Z, Jin J, Zhang Y, Zhao M, Liu G, Wang X, Yang X, Dong J, Xu Y, Zhang J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(16):e05906
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar;13(16):e05906
Fibroblast growth factor-inducible 14 accelerates pulmonary fibrosis by inducing fibroblast senescence in mice.
Guan XX, Zhong WJ, Tang WF, Liu YB, Chen MR, Li JL, Zhang CY, Zhou Y, Guan CX, Wu JN, Ma L, Duan JX
Cellular and molecular life sciences : CMLS 2026 Mar 6;83(1)
Cellular and molecular life sciences : CMLS 2026 Mar 6;83(1)
Zearalenone Induces Oxidative Stress and Apoptosis in the Jejunum of Weaned Piglets via the p53/Nrf2 Signaling Pathway.
Sang Y, Hou S, Zhang Z, Jiang S, Yang W, Cheng Q
International journal of molecular sciences 2026 Mar 5;27(5)
International journal of molecular sciences 2026 Mar 5;27(5)
Unraveling the Molecular Mechanisms Linking Cigarette Smoke Exposure to Skin Damage.
Tan Z, Wei Y, Zhang S, Song J, Zhu W
International journal of molecular sciences 2026 Mar 4;27(5)
International journal of molecular sciences 2026 Mar 4;27(5)
Mutant p53 Directs PARP to Regulate Replication Stress and Drive Breast Cancer Metastasis.
Xiao G, Annor GK, Harmon KW, Chavez V, Levine F, Ahuno S, Atmane MI, St Jean S, Rowdo FPM, Leybengrub P, Gaglio A, Ellison V, Venkatesh D, Sun S, Merghoub T, Greenbaum B, Elemento O, Davis MB, Ogunwobi O, Bargonetti J
bioRxiv : the preprint server for biology 2026 Mar 28;
bioRxiv : the preprint server for biology 2026 Mar 28;
Peroxiredoxin 4 Involved in Spermatogenesis by Affecting Oxidative Stress and Ferroptosis.
Yuan S, Wei N, Ma W, Hu M, Zhang B, Gao L, Gao C, Yang X, Meng Y, Liu J, Cui Y
Andrology 2026 Mar 27;
Andrology 2026 Mar 27;
Mechanism of platelet-rich plasma inhibiting inflammatory response, oxidative stress, and senescence in synovial fibroblasts of patients with knee osteoarthritis via UBE2C based on transcriptome sequencing analysis.
Zou L, Ma Y, Hu M, Sun Z, Shi Z, Gao J, Cai X
Journal of bioenergetics and biomembranes 2026 Mar 26;58(1)
Journal of bioenergetics and biomembranes 2026 Mar 26;58(1)
Small-molecule enhancement of METTL3 S-palmitoylation as a therapeutic strategy for osteoarthritis.
Qin W, Wei J, Li F, Wang L, Zhang Q, Chen J, Lu P, Long T, Liu A, Cao J, Deng Y, Zhang H, Chen D, Cui J, Zhao W
Cell reports 2026 Mar 24;45(3):116993
Cell reports 2026 Mar 24;45(3):116993
Optogenetic manipulation of estrogen receptor signaling to improve estrogen deficiency.
Liu J, Xie L, Wang J, Chen Q, Zhu M, Zhang L, Xie S, Lu B, Chen X, Xu Y
iScience 2026 Mar 20;29(3):115105
iScience 2026 Mar 20;29(3):115105
PCSK9 Inhibitor Alirocumab Improves Diabetic Cardiomyopathy Through the ERK/p38 MAPK Signaling Pathway.
Lin S, Wu B, Sun S, Sun T
International journal of molecular sciences 2026 Mar 2;27(5)
International journal of molecular sciences 2026 Mar 2;27(5)
Heme enhances B-cell proliferation and plasma cell formation through reduced p21 and Rb expression.
Padilla-Quirarte HO, Kania AK, Janto NV, Akdogan-Ozdilek B, Hicks SL, Roman CJ, Gupta M, Boss JM, Scharer CD
Journal of immunology (Baltimore, Md. : 1950) 2026 Mar 17;215(3)
Journal of immunology (Baltimore, Md. : 1950) 2026 Mar 17;215(3)
A novel dual-effect bimodal chip cancer research platform: Chips system interconnected vascularized tumor organoids culture with real-time exploration and detection from bench to bedside.
Ruan J, Gao C, Wang R, Hu B, Long R, Hacimuftuoglu A, Liao B, Chen L, Ma D, Xi L, Li L, Liao S
Cancer letters 2026 Mar 1;640:218110
Cancer letters 2026 Mar 1;640:218110
Targeting NAT10 alleviates colonic senescence and elderly-onset colitis by disrupting N4-acetylation of DYRK1A.
Chen J, Xue M, Mi S, Fu A, Chen W, Sun Y, Xia S, Ge Q, Luo J, Yu Q, Wang L, Chen S
Nature communications 2026 Mar 1;17(1)
Nature communications 2026 Mar 1;17(1)
Haizao Yuhu Decoction Inhibits Goiter via p53 Pathway-Induced Apoptosis: Metabolomic and Cellular Assay Analysis.
Liu X, Liao W, Xu X, Wu M, Zhang J, Wu Y, Chen S, Liu H, Zhang S, Xiu L, Zhong G
Biomedical chromatography : BMC 2026 Jun;40(6):e70452
Biomedical chromatography : BMC 2026 Jun;40(6):e70452
Exploring the potential of heterocyclic-containing tail approach in the development of novel covalent inhibitors dual-targeting EGFR and HER-2: design, synthesis and biological evaluation.
Hao S, Yan JH, Wang R, Ge GH, Si MC, Niu YF, Cai ZH, Zheng WX, Zhao CG, Li X, Cai S, Zhang TJ, Meng FH
Bioorganic & medicinal chemistry 2026 Jun;137:118637
Bioorganic & medicinal chemistry 2026 Jun;137:118637
Design and synthesis of novel 1,2,4-triazolobenzene sulfonamide derivatives as selective CDK1 inhibitors with potent in vivo anticancer efficacy.
Wu L, Wang N, Lu Y, Wang Y, Ma L, Lou G, Wang N, Jiang A, Ding L, He S, Zhang B
European journal of medicinal chemistry 2026 Jun 5;310:118799
European journal of medicinal chemistry 2026 Jun 5;310:118799
Transdermal delivery of salvianolic acid B using thermosensitive hydrogel for the treatment of skin photoaging.
Wu L, Tao Y, Xu Y, Liang Z, Zhao Y
Naunyn-Schmiedeberg's archives of pharmacology 2026 Jan;399(1):113-127
Naunyn-Schmiedeberg's archives of pharmacology 2026 Jan;399(1):113-127
Metformin alleviates presbycusis by activating the SIRT1/PINK1/GPX4 pathway in vitro and in vivo.
Zeng C, Lin W, Gu X, Chen X, Lin Y, Chen Y, Chen Z, Lin C
Inflammopharmacology 2026 Jan;34(1):729-741
Inflammopharmacology 2026 Jan;34(1):729-741
Neuroprotective effects of SRS11-92 against oxidative stress-induced senescence via Nrf2/HO-1/NF-κB in Alzheimer's disease models.
Guo Y, Cao H, Zuo C, Huang Y, Gu Z, Song Y, Chen X, Jiang Q, Wang F
Inflammopharmacology 2026 Jan;34(1):495-507
Inflammopharmacology 2026 Jan;34(1):495-507
TMEM165 promotes glioblastoma progression through epithelial-mesenchymal transition-mediated invasion and temozolomide chemoresistance.
Cheng H, Ding Y, Shen X, Wang Q, Zhang Z, Wang Y, Chen S, Zhuo S, Wang K, Yang L, Ji F, Fu Z, Lan Q, Yang K
International journal of biological macromolecules 2026 Jan;335(Pt 1):149216
International journal of biological macromolecules 2026 Jan;335(Pt 1):149216
Fe-Mn-IGF-AMD nanoparticles in accurate detection and treatment of liver cirrhosis via regulating relaxation coefficients and attenuating hepatocyte senescence.
Wang B, Ji T, Zhang Z, Duan Y, Xing Z, Duan J, Zhao S, Jia Y, Wang Q
Colloids and surfaces. B, Biointerfaces 2026 Jan;257:115182
Colloids and surfaces. B, Biointerfaces 2026 Jan;257:115182
A transcriptome-based tool for assessing skin aging reveals the ameliorative effect of stem cell-derived extracellular vesicles on UVB-induced aging.
Xie J, Wang L, Zhao S, Wang J, Cheng Y, Xu L, Kou T, Chen Y, Ying Y, Xin X, Zhang T, Xu X, Lu D, Hu X, Zhang Y, Qiu C, Wang J, Cheng G, Zhou J, Lei S, Lyu Q, Li J, Pan Y, Cao T
BMC genomics 2026 Jan 8;27(1):146
BMC genomics 2026 Jan 8;27(1):146
Time-resolved multiomics profiling reveals chromatin O-GlcNAc modification promotes senescence-associated transcriptional program.
Zhang N, Zhao R, Zhong X, Dong Q, Liu Y, Yu K, Han L, Meng F, Wu J, Chen Q, Li X, Chen Q, Zhang K, Huang H, Zhang J, Wu S, Ren Y, Wang W, Liu Y
Nature communications 2026 Jan 8;17(1):1406
Nature communications 2026 Jan 8;17(1):1406
Hypoxia promotes progression of cervical cancer by modulating the ATXN3-enhanced P53 stability or STAT5 phosphorylation.
Zhang R, Chai S, Zhang F, Lai J, Wang R, Xu G, Fan X, Li B, Cai C
Cell death discovery 2026 Jan 8;12(1):4
Cell death discovery 2026 Jan 8;12(1):4
Spil-mediated sEH overexpression contributes to the senescence of alveolar epithelial cells during pulmonary fibrosis in mice.
Zhang CY, Zhong WJ, Yang JT, Qiu YL, Sha HX, Ou AJ, Liu YB, Huang XT, Zhou Y, Duan JX, Guan CX
Journal of molecular medicine (Berlin, Germany) 2026 Jan 7;104(1):25
Journal of molecular medicine (Berlin, Germany) 2026 Jan 7;104(1):25
Simiao Decoction alleviates hyperuricemia-induced renal injury through regulating gut dysbiosis and decreasing gut-derived uremic toxins.
Zhou X, Liu X, Peng B, Yang Y, Lu H, Li D, Deng Y, Jiang Z, Wu C, Fang W, You Y, Kwan HY, Zhao X, Liu Y
NPJ biofilms and microbiomes 2026 Jan 31;12(1)
NPJ biofilms and microbiomes 2026 Jan 31;12(1)
Elucidation of the potential molecular mechanisms of Buyang Huanwu Decoction in delaying cardiac aging: Based on network pharmacology, bioinformatics, and in vivo/in vitro experimental validation.
Duan X, Deng Y, Feng M, Chen C, Yang S, Zeng S, Chen X, Xiao N, Chen X, Li J, Huang Y, Yang Y, Yu M, Wang G, Yu W, Zhang L, Wang Y, Shu Z
Journal of ethnopharmacology 2026 Jan 30;355(Pt A):120624
Journal of ethnopharmacology 2026 Jan 30;355(Pt A):120624
The p53 R181C mutation accumulates through impaired deacetylation by Sirt1 and facilitates tumor development.
Wang E, Cao L, Guo W, Dong X, Zhang W, Zhang X, Wang Z, Chen X, Li A, Zou Y, Li S, Chen K, Su H, Cao S, Du N, Wang P, Hwang PM, Liu X, Song X, Xu H, Liu J, Cao L
Communications biology 2026 Jan 3;9(1):188
Communications biology 2026 Jan 3;9(1):188
SCHEMBL4796824: a multifaceted antitumor agent targeting microtubule dynamics, DNA damage, and Wnt/β-catenin signaling in ovarian cancer cells.
Ma C, Ding X, Wang B, Zhu X, Zhang Y, Ding M, Ding X, Zhou J, Zuo D, Huang Y, Ma Y, Chen G
Journal of ovarian research 2026 Jan 3;19(1):42
Journal of ovarian research 2026 Jan 3;19(1):42
Ad-VT oncolytic adenovirus suppresses bladder cancer via cAMP-dependent AMPK-Raptor activation and G2/M arrest.
Li D, Lu J, Zhu R, Sun X, Zhang C, Sun M, Ma C, Shang C, Li X
Tumour virus research 2026 Jan 29;21:200337
Tumour virus research 2026 Jan 29;21:200337
Plasma-activated solutions reverse chronic deltamethrin exposure induced intestinal injury via rebalancing redox homeostasis and counteracting cellular senescence.
Deng X, Sun T, Wang S, Ren K, Min T, Ma Y, Peng Y, Wang X, Zhang B, Nan Y, Tong S, Liu Y, Wang W, Zhang Y, Yang Y, Li K, Dang C, Zhang H, Zhu K
Scientific reports 2026 Jan 21;16(1):2667
Scientific reports 2026 Jan 21;16(1):2667
GMCL1 controls 53BP1 stability and modulates taxane sensitivity.
Kito Y, González-Robles TJ, Kaisari S, Pae J, Garcia SF, Ortiz-Pacheco J, Ueberheide B, Marzio A, Róna G, Pagano M
eLife 2026 Jan 19;14
eLife 2026 Jan 19;14
Fullerenol Eye Drops Mitigate UVB-Induced Cataract Progression by Inhibiting Oxidative Stress and Cellular Senescence.
Zhang L, Chen S, Yu Z, Su Y, Zhao J, Hu L, Tang J, Zhang M
Antioxidants (Basel, Switzerland) 2026 Jan 16;15(1)
Antioxidants (Basel, Switzerland) 2026 Jan 16;15(1)
Bioswitchable intracellular delivery of small activating RNA by tetrahedral framework nucleic acid: Application to p21-mediated anti-tumor therapy.
Liu Y, Lin S, Liang L, Cai Z, Zhuang W, Chen X, Gao L, Li S, Lin Y
Journal of controlled release : official journal of the Controlled Release Society 2026 Jan 10;389:114488
Journal of controlled release : official journal of the Controlled Release Society 2026 Jan 10;389:114488
Inhibition of the PI3K/AKT signaling pathway blocks the oncogenic activity of TRIM26 in prostate cancer cells.
Zhong YY, Zhang LH, Zhou XY, Zhou XM, He YM, Mao XL, Xu XF
Asian journal of andrology 2026 Jan 1;28(1):89-95
Asian journal of andrology 2026 Jan 1;28(1):89-95
Catalpol attenuates postmenopausal osteoporosis by activating SIRT1-mediated P53 deacetylation and inhibiting CASPASE-3-driven osteoblast apoptosis.
Bian Y, Wang Q, Liang Q, Zhu Y, Wu C, Ruan H, Hu X
International immunopharmacology 2026 Jan 1;168(Pt 1):115820
International immunopharmacology 2026 Jan 1;168(Pt 1):115820
FBXO5 alleviates apical periodontitis by facilitating TP53 protein degradation.
Zhang R, Xiong M, Li B, Sheng L, Zhang B, Wang M, Liu J
International dental journal 2026 Feb;76(1):103948
International dental journal 2026 Feb;76(1):103948
Hsa-miR-526b-5p Regulates the Sensitivity of Colorectal Cancer to 5-Fluorouracil by Targeting TP53 in Organoid Models.
Huang L, Liao C, Xiong Z, Chen Z, Zhang S
Biochemical genetics 2026 Feb;64(1):660-683
Biochemical genetics 2026 Feb;64(1):660-683
Porphyromonas gingivalis Outer Membrane Vesicles Promote Gingival Fibroblasts Senescence via IL21R-AS1.
Li Z, Xiao Y, Ma J, Chen X, Zhou Y, Gou H, Xu Y
Journal of periodontal research 2026 Feb;61(2):203-215
Journal of periodontal research 2026 Feb;61(2):203-215
Integrating TWAS, chemical-genomic networks, and experimental models: melatonin as a ferroptosis inhibitor in osteoarthritis therapy.
Feng R, Aihaiti Y, Yu H, Xu K, Lu C, Xu P
Clinical rheumatology 2026 Feb;45(2):1559-1572
Clinical rheumatology 2026 Feb;45(2):1559-1572
A Human Kidney Tubuloid Model of Repeated Cisplatin-Induced Cellular Senescence and Fibrosis for Drug Screening.
Nakao Y, Mori M, Sekiguchi Y, Morita I, Shindoh R, Mandai S, Fujiki T, Kikuchi H, Ando F, Susa K, Mori T, Suzuki A, Nashimoto Y, Kaji H, Waseda Y, Yoshida S, Fujii Y, Sohara E, Uchida S, Miyake K, Mori Y
Advanced healthcare materials 2026 Feb;15(7):e01795
Advanced healthcare materials 2026 Feb;15(7):e01795
Remodeling Cellular Uptake via Inducing Clustering of Urokinase Receptors in Hydrogel Microspheres for Alleviating Cartilage Senescence.
Lin Z, Wu C, Du Y, Zhao D, Li Y, Wang L, Kang Y, Li Z, Zuo R, Cui W, Zhao J
Advanced healthcare materials 2026 Feb;15(5):e04034
Advanced healthcare materials 2026 Feb;15(5):e04034
WTAP Contributes to Periodontitis Pathogenesis by Promoting PDLSC Senescence and Impairing Osteogenic Differentiation via m6A-Dependent Regulation of TP53BP1.
Xiong M, Wang T, Liu Y
Immunity, inflammation and disease 2026 Feb;14(2):e70335
Immunity, inflammation and disease 2026 Feb;14(2):e70335
A Unique Chimeric RNA: ERCC1-iASPP Drives Benzo[a]pyrene-Induced Lung Carcinogenesis via Dual Coding and Non-Coding Mechanisms.
Shan M, Xiao M, Zhang L, Wang S, Wu J, Cao K, Li Y, Zhang G, Xie J, Lu X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(8):e07217
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(8):e07217
Removing therapy-induced senescent cancer cells targets and potentiates the response of pancreatic cancer cells toward PARP inhibitors as maintenance therapy.
Li Y, Jia Z, Liu X, Xia X, Zhang L, Dai H, Li S, Zhou Y, Ma L, Bai Z
Apoptosis : an international journal on programmed cell death 2026 Feb 9;31(2):71
Apoptosis : an international journal on programmed cell death 2026 Feb 9;31(2):71
UBA5 deficiency disrupts mitochondrial autophagy via the PINK1-parkin pathway and impairs myoblast proliferation.
Shi H, Cai Y, Liu Y
Biological research 2026 Feb 5;59(1)
Biological research 2026 Feb 5;59(1)
Characterization of Novel Decenoic Acid Derivatives Exhibiting Cytotoxic Activity Against T98G Glioma Cells Under a Serum- and Glucose-deprived Condition.
Ito Y, Tada N, Muraki C, Kubota Y, Kandeel M, Kitade Y, Itoh A, Oh-Hashi K
Cell biochemistry and biophysics 2026 Feb 3;
Cell biochemistry and biophysics 2026 Feb 3;
Cardiospermum halicacabum Extract Attenuates UVB-Induced Photoaging in Human Skin Fibroblasts via Inhibition of the PI3K/Akt/mTOR Signaling Pathway.
Zhao K, Zhang C, Deng C, Zhu W
International journal of molecular sciences 2026 Feb 28;27(5)
International journal of molecular sciences 2026 Feb 28;27(5)
Mechanistic Insights into Active Components of Rosa Roxburghii Juice Against Fluoride-Induced Osteoarthritis.
Du Y, Du Y, Liu S, Li J, Tian L, Yao L, Liao J, Fu L, Chen Y, Luo P, Shen X
Antioxidants (Basel, Switzerland) 2026 Feb 28;15(3)
Antioxidants (Basel, Switzerland) 2026 Feb 28;15(3)
Pramipexole alleviates ferroptosis in HT22 cells induced by oxygen-glucose deprivation/reoxygenation via the Nrf2/SLC7A11/GPX4 pathway.
Zhang L, Kang X, Wang Q, Cao Z, Gao R, Yu Y, Li T, Liu L
Scientific reports 2026 Feb 26;16(1)
Scientific reports 2026 Feb 26;16(1)
The SIRT1-Mediated p53 Deacetylation Pathway Modulates Apoptosis and Promotes Viral Replication in MVC-Infected Cells.
Yan Y, Ren X, Xiao Y, Li F, Guo J, Ji K, Hei Z, Zhang Z, Sun Y
Pathogens (Basel, Switzerland) 2026 Feb 25;15(3)
Pathogens (Basel, Switzerland) 2026 Feb 25;15(3)
Preparation of Artemisia argyi-Derived Extracellular Nanovesicles and Their Protective Effects Against Oxidative Stress-Induced Senescence in Endometrial Stromal Cells.
Zheng X, Huang R, Liu Z, Liu T, Lin H, Yin L, Wu Q, Zhao M
Bioengineering (Basel, Switzerland) 2026 Feb 24;13(3)
Bioengineering (Basel, Switzerland) 2026 Feb 24;13(3)
Curcumin-loaded silk fibroin scaffold promotes cartilage regeneration by inhibiting angiogenesis via Drp1/ROS-mediated mitochondrial regulation.
Zhao Z, Fu J, Han J, Pan Y, Xue B, Sun X, Ma Y, Li B, Chen K, Li Z, Liang Z, Zhou X, Guo Y, Tu P
Journal of biological engineering 2026 Feb 2;20(1)
Journal of biological engineering 2026 Feb 2;20(1)
Synergistic microenvironment therapy: a dual-function nanogel of supramolecular collagen ll-mimetic matrix and antioxidant MXene for attenuating intervertebral disc degeneration.
Lyu G, Gao Z, Cao Z, Zhou Q, Chen Y, Yang S, Liang H, Lu X, Li S, Wang X, Sun S, Gao X, Zhou Y, Wu A, Zhou X, Wang X
Journal of nanobiotechnology 2026 Feb 19;24(1)
Journal of nanobiotechnology 2026 Feb 19;24(1)
p53 regulates early mucosal immunity via antigen presentation in zebrafish intestine post-SVCV vaccination.
Zhao Z, Wei XF, Zhao L, Xia JY, Li YY, Jia YJ, Zhu B
Cell communication and signaling : CCS 2026 Feb 17;24(1)
Cell communication and signaling : CCS 2026 Feb 17;24(1)
T-cell apoptosis is more susceptible to overactivated neutrophils delivered-NETs-MPO/NE complex.
Lu C, Shao L, Li H, Gao X, Mei Y, Sun B
International immunopharmacology 2026 Feb 1;170:116100
International immunopharmacology 2026 Feb 1;170:116100
Pregnane X receptor mitigates aristolochic acid-induced acute kidney injury via p53 ubiquitination.
Liu Q, Deng F, Chen A, Liu Y
Renal failure 2026 Dec;48(1):2630492
Renal failure 2026 Dec;48(1):2630492
Identification of mitochondrial permeability transition-related gene signatures to predict lung adenocarcinoma survival and drug response.
Liu L, Gao M, He W, Wang M, Zhou S, Wang X, Shu Y
Cell cycle (Georgetown, Tex.) 2026 Dec;25(1):1-35
Cell cycle (Georgetown, Tex.) 2026 Dec;25(1):1-35
Engineered extracellular vesicles from human placental mesenchymal stem cells attenuate abdominal aortic aneurysm formation by inhibiting Nat10-mediated vascular smooth muscle cell senescence.
Jia X, Hu X, Fu Z, Zhang L, Luo X, Huang W, Hua Y, Fang Q, Zeng J, Huang F, Wei G, Bin J, Zheng H, Chen G, Huang S
Biomaterials 2026 Aug;331:124109
Biomaterials 2026 Aug;331:124109
RFRP-3 suppresses ovarian granulosa cell function in Tan sheep via dual signaling pathways: PI3K/AKT/mTOR and MAPK/ERK1/2.
Wei S, Dai T, Song W, Ma Y, Dan X
Theriogenology 2026 Aug;260:117909
Theriogenology 2026 Aug;260:117909
TP53 links mitochondria-endoplasmic reticulum crosstalk and ferroptosis in septic cardiomyopathy: Protective modulation by nicorandil.
Lu J, Tao Y, Li J, Wubuliaila M, Wang J, Li N
Cellular signalling 2026 Aug;144:112537
Cellular signalling 2026 Aug;144:112537
Kaempferol Mitigates Liver Injury Induced by Copper Toxicity Through the Activation of the Sirt1/Nrf2/FOXO3 Signaling Pathway.
Xu J, Wan W, Mu H, Gong S, Liu Y, Deng T
Journal of biochemical and molecular toxicology 2026 Apr;40(4):e70813
Journal of biochemical and molecular toxicology 2026 Apr;40(4):e70813
PLLP inhibits the progression of WT p53 gastric cancer by reducing p53 protein ubiquitination by binding to TRIM59.
Quan Z, Lin L, Xu F, Zhou C, Huang R, Sun K, Jiang H
The Journal of biological chemistry 2026 Apr;302(4):111341
The Journal of biological chemistry 2026 Apr;302(4):111341
SLC2A3-Mediated Lactate Metabolism Promotes Lung Cancer Bone Metastasis by Modulating P53 Lactylation and Immune Evasion.
Ding Y, Tian Y, Ren W, Hu X, Li M, Liu B, Chen C, Lu Y, Li L, Yan W, Li K
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(22):e16622
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(22):e16622
KRAB Zinc-Finger Protein ZNF205 Promotes Hepatocellular Carcinoma via p53 Pathway Repression.
Huang X, Yang Y, Ma Y, Hao W, Jin J, Ding Y, Zhang Y, Zhang X, Li X, Song Q, Liu J, Liu B, Zhai Y, Zhao C, Wu J, Tian C
Cancer science 2026 Apr;117(4):1057-1071
Cancer science 2026 Apr;117(4):1057-1071
GL-V9 disrupts the mitochondrial homeostasis and triggers the integrated stress response by promoting the binding of cytosolic MDM2 with NDUFS1 in colorectal cancer.
Zhang Y, Xun C, Shi C, Wang R, Gao Y, Pan D, Guo Y, Wei L
Journal of advanced research 2026 Apr 7;
Journal of advanced research 2026 Apr 7;
Triple-Targeted Peptide-Photosensitizer-Drug Conjugate Enables NIR-II Imaging-Guided Multimodal Therapy Against Osteosarcoma.
He X, Liang X, Yu J, Rong J, Hu J, Xu C, Cai Z, Chen J, Zhang Y, Pu X, Sun P, Wu H, Sun B
ACS nano 2026 Apr 28;20(16):12577-12595
ACS nano 2026 Apr 28;20(16):12577-12595
Multiomics profiling and experiments in preclinical models revealed RAD51-IN-1 as a synergistic potentiator of anlotinib sensitivity.
Meng H, Chang Q, Zhang Y, Ren J, Guo H, Yu L, Qian C, Jiang Y, Zhang L, Cheng W
Science advances 2026 Apr 17;12(16):eaeb0855
Science advances 2026 Apr 17;12(16):eaeb0855
KLOTHO Deficiency Drives Ovarian Aging by Inducing Granulosa Cell Senescence and Dysfunction.
Du W, Liu A, Li H, Ma X, Yang Y
Reproductive sciences (Thousand Oaks, Calif.) 2026 Apr 17;
Reproductive sciences (Thousand Oaks, Calif.) 2026 Apr 17;
Peroxisome-derived and liver-specific hydroxyacid oxidase 1-mediated hydrogen peroxide promotes ferroptosis by augmenting peroxisomal ROS.
Peng X, Zhou Y, Chen J, Wang Z, Peng X, Wang H, Shu L, Liu N, Long Y, Linghu L, Zhang Z, Peng Y, Zhao Y, Xiao D, Shi Y, Liu S, Tao Y
Journal of advanced research 2026 Apr 15;
Journal of advanced research 2026 Apr 15;
FBXO39 promotes LDHA-mediated aerobic glycolysis and colorectal cancer progression by p53 degradation.
Liu J, Xiao T, Huang J
Journal of translational medicine 2026 Apr 1;24(1)
Journal of translational medicine 2026 Apr 1;24(1)
Youthful Brain-Derived Extracellular Vesicle-Loaded GelMA Hydrogel Promotes Scarless Wound Healing in Aged Skin by Modulating Senescence and Mitochondrial Function.
Wu Y, Mao J, Zhou Y, Hong G, Wu H, Hu Z, Huang X, Shi J, Xie Z, Lan Y
Research (Washington, D.C.) 2025;8:0644
Research (Washington, D.C.) 2025;8:0644
Quercetin, a Natural Dietary Flavonoid, Emerges a Novel USP7 Inhibitor with Anti-colorectal Cancer Effects.
Li X, Li Q, Huang Y, Zhou H, Yang Q, Kong L
Biological & pharmaceutical bulletin 2025;48(10):1485-1492
Biological & pharmaceutical bulletin 2025;48(10):1485-1492
DARS2 Promotes Bladder Cancer Progression by Enhancing PINK1-Mediated Mitophagy.
Li D, Su H, Deng X, Huang Y, Wang Z, Zhang J, Chen C, Zheng Z, Wang Q, Zhao S, Chen ZS, Chen H, Hou L, Tan W, Li F
International journal of biological sciences 2025;21(4):1530-1544
International journal of biological sciences 2025;21(4):1530-1544
Exendin-4 Reduces Senescence of Inflammation-Induced Periodontal Ligament Stem Cells Through SIRT1/Notch1 Signaling.
Xu Y, Zheng J, Liu M, Fu Z, Wang P
Stem cells international 2025;2025:7639451
Stem cells international 2025;2025:7639451
Bionic Power Play: Dual-Targeting MDMX/MDM2 to Reboot p53 to Beat Lung Adenocarcinoma's Immune Tricks.
Wong S, Xu L, You W, He W, Zheng X, Qi Z
International journal of nanomedicine 2025;20:9885-9897
International journal of nanomedicine 2025;20:9885-9897
Tetrahedral Framework Nucleic Acids Inhibit Oxidative Stress and Cardiomyocyte Apoptosis in Doxorubicin-Induced Cardiotoxicity.
Pan H, Ye Q, Li Y, Ma L, Ni Y
International journal of nanomedicine 2025;20:9275-9289
International journal of nanomedicine 2025;20:9275-9289
Boron Phenylalanine-Modified Polydopamine Nanoparticles for Targeted Delivery of Danusertib in Non-Small Cell Lung Cancer.
Xu Y, Chen X, Zhang L, Li P, He J, Zhu M, Makvandi P, Jin X
International journal of nanomedicine 2025;20:8415-8432
International journal of nanomedicine 2025;20:8415-8432
MAP17 is a Novel NASH Progression Biomarker Associated with Macrophage Infiltration, Immunotherapy Response, and Oxidative Stress.
Huang Z, Chen J, Liu S, Xiang X, Long Y, Tan P, Fu W
Journal of inflammation research 2025;18:601-619
Journal of inflammation research 2025;18:601-619
TRIM6 Promotes Cell Cycle and Growth by Modulating p53 Signaling Pathway in Lung Adenocarcinoma.
Lu X, Wang H, Yu T
International journal of general medicine 2025;18:2107-2117
International journal of general medicine 2025;18:2107-2117
Acupotomy Ameliorates KOA Related Chondrocyte Premature Senescence Through YAP/FOXD1 Pathway.
Ma Y, Hu T, Liu N, Guo C, Xing L, Ma W, Cui Y, Chen X
Journal of pain research 2025;18:2011-2023
Journal of pain research 2025;18:2011-2023
Astragaloside IV Alleviates Osteoarthritis by Inhibiting Chondrocyte Ferroptosis via the p53/SLC7A11/GPX4 Axis.
Tang Z, Cheng L, Li M, Chen J, Huang C
Journal of inflammation research 2025;18:16169-16186
Journal of inflammation research 2025;18:16169-16186
Fatty Acid Transporter CD36 Promotes Ox-LDL-Induced Senescence of Vascular Endothelial Cells in Preeclampsia.
Xiao Y, Tao M, Yu Y, Bai R, Zhuang Y, Huang Q, He J, Lin Z, Gao M, Li J, Wang Y, Xu Y, Shen X, Huang Z, Yao Y, Chen Z, Chen Q, Wang Z
Journal of inflammation research 2025;18:12801-12816
Journal of inflammation research 2025;18:12801-12816
Ginsenoside Rg3 exerts anticancer effects in lung cancer through metabolite Histon H3.
Xiao H, Zhang Y, Zhang B, Wu J, Li X
American journal of translational research 2025;17(5):3994-4007
American journal of translational research 2025;17(5):3994-4007
Carnosic acid attenuates diabetic retinopathy via the SIRT1 signaling pathway: neuroprotection and endothelial cell preservation.
Mai H, Liu C, Fu B, Ji X, Chen M, Zhang Y, Lin Y, Chen J, Song Y, Gu S
American journal of translational research 2025;17(3):2293-2310
American journal of translational research 2025;17(3):2293-2310
GDF15 is associated with thyroid cancer progression and may modulate thyroid cancer cell senescence in a p53-dependent manner.
Ma J, Liu Z, Hua R, Ding C, Yang Z, Liang W, Lv B
Frontiers in endocrinology 2025;16:1675245
Frontiers in endocrinology 2025;16:1675245
Identification of an Ara-C resistance-related gene risk score and the role of S100A4 in AML via NR6A1-dependent activation and p53 regulation.
Wang L, Huang A, Cheng B, Hu X, Wang J
Frontiers in pharmacology 2025;16:1574759
Frontiers in pharmacology 2025;16:1574759
Synergistic effects of retinol and retinyl palmitate in alleviating UVB-induced DNA damage and promoting the homologous recombination repair in keratinocytes.
Zhong J, Liang L, Zhao N, Wang J, Shu P
Frontiers in pharmacology 2025;16:1562244
Frontiers in pharmacology 2025;16:1562244
Dehydrodiisoeugenol targets the PLK1-p53 axis to inhibit breast cancer cell cycle.
Li L, Zheng Y, Yang Y, Shi S, Liu S, Huang K, Qiu L, Zhang R, Huang W, Leng Y
Frontiers in pharmacology 2025;16:1545498
Frontiers in pharmacology 2025;16:1545498
Saikosaponin A induces cellular senescence in triple-negative breast cancer by inhibiting the PI3K/Akt signalling pathway.
Wu Y, Chen L, Pi D, Cui J, Liang Y, Wu P, Ouyang M, Zuo Q
Frontiers in pharmacology 2025;16:1532579
Frontiers in pharmacology 2025;16:1532579
Gallic acid protects intervertebral disc cells from ferroptosis and alleviates intervertebral disc degeneration by regulating key factors of oxidative stress.
Zhu Z, Huang Z, Zhang C, Xu B, Chen H, Pei S, Zhang B, Jie L, Shi X, Liu Y, Li Y, Shen X
Frontiers in pharmacology 2025;16:1501725
Frontiers in pharmacology 2025;16:1501725
Targeting the N-cadherin/β-catenin axis with MSAB reverses malignant phenotypes in blast crisis of CML.
Zhou Y, Jian S, Lu L, Li X, Qiu R
Frontiers in oncology 2025;15:1657508
Frontiers in oncology 2025;15:1657508
Repurposing riluzole as an anti-osteosarcoma agent.
Jung O, Rajasekhar VK, Azeem SM, ChandThakuri S, Norton B, Healey JH, Mahajan S
Frontiers in oncology 2025;15:1508819
Frontiers in oncology 2025;15:1508819
IL-6/GATA2/SERPINE1 pathway is implicated in regulating cellular senescence after acute kidney injury.
Su H, Lin X, Paredong A, Yao C, Zhang Y, Geng M, Guan Y, Gong L, Jiang F, Lv Q, Shou S, Jin H
Frontiers in molecular biosciences 2025;12:1538526
Frontiers in molecular biosciences 2025;12:1538526
Impaired stemness in aging periodontal ligament stem cells is mediated by the progerin/endoplasmic reticulum stress/p53 axis.
Zhang X, Wang Y, Wang J, Zhang Y, Li R, Wang X, Ge X, Ye Q, Ji J, Fei D, Wang Q
Journal of advanced research 2025 Sep;75:377-388
Journal of advanced research 2025 Sep;75:377-388
3-Indolepropionic acid confers PXR-p53 binding to mitigate deoxynivalenol-induced hepatocyte apoptosis.
Feng Y, Lin Z, Wang H, Men Z, Shen J, Ma X
Science China. Life sciences 2025 Sep;68(9):2707-2722
Science China. Life sciences 2025 Sep;68(9):2707-2722
Phytosphingosine Alleviates Cigarette Smoke-Induced Bronchial Epithelial Cell Senescence in Chronic Obstructive Pulmonary Disease by Targeting the Free Fatty Acid Receptor 4.
Zhan Y, Deng Z, Yang R, Chen S, Zhang J, Zhang Y, Fu H, Huang Q, Gu Y, Zeng Z, Chen J, Zhang J, Wu J, Xie J
MedComm 2025 Sep;6(9):e70345
MedComm 2025 Sep;6(9):e70345
Notoginsenoside R2 attenuates hepatic fibrosis via STAT3-dependent hepatic stellate cells senescence induction and inflammatory microenvironment suppression.
Deng K, Li M, Li Y, Xiang L, Wang Y, Shi H, Cheng J, Huang S, Lv Z
Journal of ginseng research 2025 Sep;49(5):574-584
Journal of ginseng research 2025 Sep;49(5):574-584
ACSL5 regulated acetyl-CoA to promote bladder cancer cellular senescence via 53BP1 acetylation.
Luo Y, Zeng Y, Liu Y, Liu S, Dai Y, Pan W, Zhang L, Zhu R, Feng D, Du K, Zhang X, Jia B, Tian F, Zhou L, Gu C
Oncogene 2025 Sep;44(34):3096-3112
Oncogene 2025 Sep;44(34):3096-3112
Exploring the potential mechanism of atorvastatin in regulating ferroptosis as a treatment for heart failure based on network pharmacology.
Bai YT, Wang YQ, Liu YM, Gong ZX, Wugeng S, Guo WL, Shi MZ, Liu XQ, Su XL
Naunyn-Schmiedeberg's archives of pharmacology 2025 Sep;398(9):12227-12239
Naunyn-Schmiedeberg's archives of pharmacology 2025 Sep;398(9):12227-12239
Ubiquitin-specific protease 7-mediated stabilization of discoidin domain receptor 1 drives progression of TP53-Mutant cancers.
Xue Y, Xiu B, Yang M, Zhang Y, Yang C, Zhang L, Yan Y, Luo X, Huang Y, Mei H, Li G, Zhou L, Chen Y, Zhang W, Qian C, Zhang P, Liu J, Liang A, Zeng Y, Yang J
The Journal of biological chemistry 2025 Sep;301(9):110515
The Journal of biological chemistry 2025 Sep;301(9):110515
Comprehensive Pan-Cancer Analysis of TRNT1 as a Potential Biomarker for Breast Cancer.
Li X, Meng Y, Gu B
Journal of cellular and molecular medicine 2025 Sep;29(18):e70853
Journal of cellular and molecular medicine 2025 Sep;29(18):e70853
Glutaredoxin 1 enhances endothelial cell angiogenesis by reducing VEGFA S-glutathionylation and delays vascular endothelial cell senescence.
Li F, Cui X, Yan Y, Jing X, Bai C, He D, Wang L, Gao C, Li M, Feng R
Free radical biology & medicine 2025 Sep;237:515-529
Free radical biology & medicine 2025 Sep;237:515-529
A genome-wide analysis of YY1 and TFAP2 competition on overlapping motifs reveals their roles in HPV-induced carcinogenesis.
Liu Y, Ding S, Liu H
PLoS pathogens 2025 Sep;21(9):e1013524
PLoS pathogens 2025 Sep;21(9):e1013524
Energy metabolism disturbance induced by atorvastatin exposure on yellowstripe goby (Mugilogobius chulae) larvae based on transcriptome and metabolome analysis.
Zhao Y, Wang Y, Gong W, Duan C, Ren J, Zhang H, Nie X
Journal of environmental sciences (China) 2025 Sep;155:475-487
Journal of environmental sciences (China) 2025 Sep;155:475-487
Suppressed autophagy of thymic cells promotes apoptosis and thymic atrophy in COPD.
He S, Yang Z, Xie L
Heart & lung : the journal of critical care 2025 Sep-Oct;73:180-189
Heart & lung : the journal of critical care 2025 Sep-Oct;73:180-189
MKRN2 attenuates LPS-induced apoptosis in lung epithelial cells via ubiquitination-mediated p53 degradation.
Ma R, Su H, Liu J
Biochemical and biophysical research communications 2025 Sep 25;781:152476
Biochemical and biophysical research communications 2025 Sep 25;781:152476
Nuclear FGF2 orchestrates phase separation-mediated rDNA chromatin architecture to control BMSCs cell fate.
Zhang H, Wang Z, Liu Z, Li X, Sun W, Zhen W, Xu F, Wang R, Yin Q, Cao S, Wu M, He J, Xu J, Li Y, Yuan Q
Bone research 2025 Sep 24;13(1):80
Bone research 2025 Sep 24;13(1):80
NGAL knockdown alleviated CSE-induced cellular senescence and reduced MMP2 and MMP9 expression in alveolar macrophages through the PI3K/Akt pathway.
Wang Y, Jin C, Zheng Y, Wang J
European journal of medical research 2025 Sep 23;30(1):850
European journal of medical research 2025 Sep 23;30(1):850
Melatonin attenuates ischemia-reperfusion-induced acute kidney injury by regulating abnormal autophagy and pyroptosis through SIRT1-mediated p53 deacetylation.
Sun C, Liu J, Li H, Yan Y
International immunopharmacology 2025 Sep 23;162:115092
International immunopharmacology 2025 Sep 23;162:115092
Colla Corii Asini regulate collagen regeneration in UV exposure-induced skin photoaging in mice.
Ma Y, Huang J, Gong J, Li L, Zhao Y, Jin Y, Gu J, Liu H, Wang Y, Sun Y
Chinese medicine 2025 Sep 22;20(1):146
Chinese medicine 2025 Sep 22;20(1):146
Arylsulfatase K attenuates airway epithelial cell senescence in COPD by regulating parkin-mediated mitophagy.
Yang R, Zhan Y, Deng Z, Zhang J, Chen S, Zhang Y, Fu H, Meng X, Wu J, Gu Y, Huang Q, Wang C, Xie J
Redox biology 2025 Oct;86:103793
Redox biology 2025 Oct;86:103793
cZFP609 Tethering BiP Alleviates Cartilage Degradation in Osteoarthritis via Remedying Aberrant ER-Mitochondrial Contacts.
Song Y, Luo JL, Zhang F, Shi J, Du S, Jiang HB, Zhang WD, Chen SY, Zhang DD, Kong P, Gao Y, Han M, Li H
MedComm 2025 Oct;6(10):e70405
MedComm 2025 Oct;6(10):e70405
WTAP Silencing protects human aortic smooth muscle cells from angiotensin II-induced senescence, apoptosis, ferroptosis, and inflammation by regulating PCSK9.
Pang H, Fu B, Wang P, Meng Y, Xie P, Hu X, Ma Q
Journal of bioenergetics and biomembranes 2025 Oct;57(4-5):231-244
Journal of bioenergetics and biomembranes 2025 Oct;57(4-5):231-244
Canagliflozin improves high-salt-induced aortic arteriosclerosis and premature aging in dahl salt-sensitive rats through the SIRT6/HIF-1 α signaling pathway.
Wang Q, Liang Y, Zuo Q, He L, Zhang T, Wang Z, Zhai J, Cao B, Ma S, Zhang G, Lu F, He K, Wang Y, Guo Y
Molecular and cellular biochemistry 2025 Oct;480(10):5369-5385
Molecular and cellular biochemistry 2025 Oct;480(10):5369-5385
Hydrogen Sulfide Ameliorates Heart Aging by Downregulating Matrix Metalloproteinase-9.
He K, Zhang H, Tan B, Song C, Liang Z, Zhang L, Tian D, Xiao L, Xue H, Guo Q, Teng X, Jin S, An C, Wu Y
Cardiovascular drugs and therapy 2025 Oct;39(5):967-981
Cardiovascular drugs and therapy 2025 Oct;39(5):967-981
Centipede Polypeptide Affects the Inflammatory Reaction and Ferroptosis of Liver Cancer Cells Through the p53/TRAIL Pathway.
Xing X, Lu L, Huang Z, Wang J, Wang L, Hu Y, Yin S, Tian S
Journal of cellular and molecular medicine 2025 Oct;29(19):e70844
Journal of cellular and molecular medicine 2025 Oct;29(19):e70844
cTAGE5/MEA6 Regulates LBR Localization to Maintain Nuclear Envelope Integrity and Safeguard Against Aging.
Wang Y, Sun P, Yang F, Ma T, Fan J, Shi L, Li N, Gao F, He K, Xu Z
Aging cell 2025 Oct;24(10):e70185
Aging cell 2025 Oct;24(10):e70185
Arginyl-fructosyl-glucose (AFG), a major Maillard reaction product of red ginseng, improved kidney and pancreatic injury in vitro and in vivo in type 2 diabetes mellitus.
Tsopmejio ISN, Tang S, Gao XF, Liu Z, Li XD, Qi MH, Zhu HY, Wang Z, Li W
International immunopharmacology 2025 Oct 30;164:115378
International immunopharmacology 2025 Oct 30;164:115378
Neuronal pentraxin 1 accelerates post-stroke atherosclerosis by inducing endothelial cell senescence.
Wu Y, Luo R, Guan H, Zhang X, Yang X, Wang W, Li Q
International immunopharmacology 2025 Oct 30;164:115363
International immunopharmacology 2025 Oct 30;164:115363
α-hederin inhibits cervical cancer progression by inducing DNA damage-dependent cell cycle blockade and apoptosis.
Song Y, Qin H, Huang S, Wang J, Huang Y, Lin Z, Yang F, Zhang X, Wang R, Wang J
BMC cancer 2025 Oct 3;25(1):1503
BMC cancer 2025 Oct 3;25(1):1503
Luteoloside alleviates bleomycin-induced pulmonary fibrosis in mice via SIRT1-mediated protective effect against alveolar epithelial cell senescence.
Deng L, Sun B, Xia J, Zhuo W, Jiang M, Yin S, Yang F
Scientific reports 2025 Oct 29;15(1):37837
Scientific reports 2025 Oct 29;15(1):37837
Novel E-F ring derivatives of aconitine scaffold as potent Hsp90 inhibitors for the treatment of colorectal cancer.
Zhang Y, Wang YP, Guo S, Li TT, Wang QY, Zhang X, Zheng YM, Wen YQ, Meng FH, Zhang TJ
European journal of medicinal chemistry 2025 Oct 15;296:117895
European journal of medicinal chemistry 2025 Oct 15;296:117895
PARP1 promoter hypermethylation promotes arsenic-induced skin damage by driving telomere dysfunction-mediated keratinocyte senescence.
Yang L, Wang W, Zhang A
Ecotoxicology and environmental safety 2025 Oct 1;304:119108
Ecotoxicology and environmental safety 2025 Oct 1;304:119108
Transcriptomic Analysis of the Effects of Hydroxysafflor Yellow A on hUC-MSC Senescence via the ECM-Receptor Interaction Pathway.
Wang S, Zhu Q, Feng X, Chou X, Lu T
International journal of molecular sciences 2025 Oct 1;26(19)
International journal of molecular sciences 2025 Oct 1;26(19)
Harnessing TP73‑targeted nintedanib: A novel strategy to halt triple‑negative breast cancer via p53‑PPARα/PI3K‑Akt pathway suppression.
Zou X, Li S, Huang S, Niu R, Liu G, Wang Z
International journal of oncology 2025 Nov;67(5)
International journal of oncology 2025 Nov;67(5)
RIPK4-p53 interaction drives aflatoxin B1-induced renal mitochondrial apoptosis via Ser15 phosphorylation: A CRISPR-Cas9 mechanistic study.
Ma Y, Zhao Q, Yuan J, Wang D, Chen X, Yu Y, Li J, Yu M, Yuan J, Lou J, Du S, Wen Y, Wang Y, Wu R, Yan QG, Huang X, Zheng Y, Zhao F, Cao SJ
International journal of biological macromolecules 2025 Nov;330(Pt 3):148130
International journal of biological macromolecules 2025 Nov;330(Pt 3):148130
Structural characterization and functional role of SLC7A6 in GSSG transport and Ferroptosis regulation.
Yan G, Chen M, Lu Z, Huang H, Wang X, Qin W, Mo S, Zhong P, Han C, Ye X
International journal of biological macromolecules 2025 Nov;330(Pt 3):148008
International journal of biological macromolecules 2025 Nov;330(Pt 3):148008
Autophagic damage in senescent bone marrow mesenchymal stromal cells: Impact on Piezo1 expression during osteoporosis progression.
Huang C, Chen X, Wu D, Chen J, Wang J, Li S, Hu J, Yan Z, Zhu Y, Zhang Y
International journal of biological macromolecules 2025 Nov;330(Pt 1):147928
International journal of biological macromolecules 2025 Nov;330(Pt 1):147928
Targeting LARP1 to mitigate aging in lens epithelial cells: mechanistic insights into mitochondrial dysfunction.
Qi H, Sun L, Chai J, Ma J, Yu H, Xia M, Hu X
Experimental eye research 2025 Nov;260:110582
Experimental eye research 2025 Nov;260:110582
NSUN6 Promotes Gastric Cancer Progression by Stabilizing CEBPZ mRNA in a m(5)C-Dependent Manner.
Guo J, Wu B, Wang S, Huang D, Hu Y
Applied biochemistry and biotechnology 2025 Nov;197(11):7296-7313
Applied biochemistry and biotechnology 2025 Nov;197(11):7296-7313
Establishment and characterization of canine mammary tumors 622: A novel luminal B CMT cell line exhibiting partial epithelial-mesenchymal transition and intermediate drug sensitivity.
Peng Q, Ma S, Lu Z, Shi J, Zheng Q, Zhang T
Veterinary world 2025 Nov;18(11):3306-3321
Veterinary world 2025 Nov;18(11):3306-3321
Biotransformation of steroid hormones by intestinal fungi and their special cytotoxicity on HeLa cancer cells.
Tian M, Han C, Hu Y, Luan S, Tian X, Guo P, Li X, Sui L, Wang C, Ma X, Li D
Bioorganic chemistry 2025 Nov;166:109102
Bioorganic chemistry 2025 Nov;166:109102
Organoid-based two-step drug screening for rapid identification of chemotherapy-resistant oesophageal squamous cell carcinoma and alternative therapies.
Shao CY, Ju S, Tong X, Hu K, Li Y, Zhu YX, Yang J, Li C, Xie YF, Cui Y, Deng WJ, Ding C, Qin SB, Zhao J
Clinical and translational medicine 2025 Nov;15(11):e70534
Clinical and translational medicine 2025 Nov;15(11):e70534
Dendrobin A inhibits gastric cancer: Mechanistic insights supported by integrated evidence.
Fan Y, Chen Y, Lu W, Shi K, Zhao Y, Zhang C, Shen Z, Zheng S, Jie W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov;147:157215
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov;147:157215
Hydrogen sulfide alleviates vascular smooth muscle cell senescence by inhibiting endoplasmic reticulum stress.
Jiao L, Yan Q, Yang J, Wu R, Wei Z, Ruan J, Yan G, Chen X, Li H
Cellular signalling 2025 Nov;135:112075
Cellular signalling 2025 Nov;135:112075
CX-5461 inhibits cell proliferation and induces ferroptosis of colorectal cancer cells by inactivating Nrf2 pathway.
Chang X, Zhang Y, Wang Q, Yang W, Zhang R, Cong X, Xiao W, Piao J, Lin Z, Jin A
Cellular signalling 2025 Nov;135:111998
Cellular signalling 2025 Nov;135:111998
TP53-dependent antitumor effects of DHODH Inhibition in nasopharyngeal carcinoma.
Dong X, Zhang Y, Zhang Z, Liu T, Gu D
Discover oncology 2025 Nov 30;17(1):14
Discover oncology 2025 Nov 30;17(1):14
Melatonin Rescues Triclosan-Disrupted Porcine Oocyte Meiosis via Suppression of p53-Mediated Apoptosis.
Duan J, Zhao N, Wang S, Li X, Li B, Cao G
Animals : an open access journal from MDPI 2025 Nov 3;15(21)
Animals : an open access journal from MDPI 2025 Nov 3;15(21)
Helicobacter pylori Lipopolysaccharide Upregulates MDM2 via the TLR4/MAPK/AP-1 Pathway to Promote Gastric Cancer Progression.
Li Y, Xu L, Lu X, Fu B, Jiang Q, Xiong W, Tang W, Wu D
Digestive diseases and sciences 2025 Nov 29;
Digestive diseases and sciences 2025 Nov 29;
A serum-free adipose-conditioned medium delays stem cell senescence and maintains tissue homeostasis via IL-6/STAT3 axis suppression.
Li J, Song L, Song D, Su Z, Bi J, Huo R
Stem cell research & therapy 2025 Nov 28;16(1):668
Stem cell research & therapy 2025 Nov 28;16(1):668
p53-mediated regulation of electron transport chain and nucleotide synthesis during Newcastle disease virus infection.
Zhao C, Tang N, Wang J, Qu Y, Tan L, Song C, Qiu X, Liao Y, Luo T, Ding C, Sun Y
Journal of virology 2025 Nov 25;99(11):e0157625
Journal of virology 2025 Nov 25;99(11):e0157625
Multi-Target Botanical Complex Attenuates Cellular Senescence via Bidirectional P21/P53/SIRT1 Regulation: Dual Model Validation.
Wu J, Dongzhu N, Zhao C, Liang J, Wang N, Suonan D, Sun S
International journal of molecular sciences 2025 Nov 25;26(23)
International journal of molecular sciences 2025 Nov 25;26(23)
Microenvironment-responsive multifunctional enzyme-linked hydrogel for diabetic bone defect regeneration.
Fu X, Luo Z, Guo Y, Meng W, Jin S, Chen J, Cai Y, Luo Z, Huang C, Chen A, Guo S, Chen M, Zhou Z, Zeng W
Nature communications 2025 Nov 21;16(1):10275
Nature communications 2025 Nov 21;16(1):10275
FTO Suppresses Dental Pulp Stem Cell Senescence by Destabilizing NOLC1 mRNA.
Li B, Xu M, Huang J, Jia R
Biomolecules 2025 Nov 19;15(11)
Biomolecules 2025 Nov 19;15(11)
Integrative Transcriptomic and Metabolomic Analysis Reveals That Acanthopanax senticosus Fruit Ameliorates Cisplatin-Induced Acute Kidney Injury by Suppressing the NF-κB/PI3K-AKT Pathway via UGT1A1 Regulation.
Han L, Tang Z, Ma X, Zhang Q, Han Y, Wang Q, Liu J, Bian X, Gao L, Xu M, Sun X
International journal of molecular sciences 2025 Nov 18;26(22)
International journal of molecular sciences 2025 Nov 18;26(22)
CDC26 facilitates ferroptosis through SLC7A11 degradation and cell cycle arrest.
Lin J, Chen F, Tang H, Cai X, Huang M, Liang R, Kang R, Tang D, Liu J
Clinical and experimental medicine 2025 Nov 18;26(1):11
Clinical and experimental medicine 2025 Nov 18;26(1):11
Mesoporous Silica Nanoparticles for Quercetin-Controlled Delivery to Protect Cisplatin-Induced Ototoxicity.
Shen M, Wang H, Liu J, Zhou Z, Wu X, Fan H, Du H, Qiu Y, Liu D, Ma D, Wang Y, Tang Z, Yang S, Zhang Y, Zhang T, Gao X
ACS applied bio materials 2025 Nov 17;8(11):10419-10435
ACS applied bio materials 2025 Nov 17;8(11):10419-10435
Epigenetic silencing of MSTN via m6A modification underlies the renoprotective effects of engineered MSC exosomes with RBM15 depletion in diabetic nephropathy.
Dong Q, Dong L, Zhu Y, Wang X, Yan X
Functional & integrative genomics 2025 Nov 17;25(1):244
Functional & integrative genomics 2025 Nov 17;25(1):244
Distinct functional heterogeneity of TP53 R175 mutations in platinum-resistant ovarian cancer: unveiling molecular mechanisms and therapeutic targets.
Liu Y, Zheng Z, Ni M, Mao S, Xiao Y, Zhao Y, Tian B, Wang L, Xu H, Hua Y
Cell death & disease 2025 Nov 17;16(1):837
Cell death & disease 2025 Nov 17;16(1):837
Leucokinin VIII acetate mitigates asthma severity by targeting ADCK5-induced cellular senescence.
Feng L, Zhong Y, Li L, Zhang M, Zhu M, Wang J, Huang M, Ji N, Ma Y
International immunopharmacology 2025 Nov 14;165:115426
International immunopharmacology 2025 Nov 14;165:115426
Downregulating FGGY carbohydrate kinase domain containing promotes cell senescence by activating the p53/p21 signaling pathway in colorectal cancer.
Liu L, Wu M, Chen Y, Cheng Y, Liu S, Zhang X, Xie Q, Cao L, Wei L, Fang Y, Jafri A, Sferra TJ, Shen A, Li L
International journal of molecular medicine 2025 May;55(5)
International journal of molecular medicine 2025 May;55(5)
mRNA metabolism regulator human antigen R (HuR) regulates age-related hearing loss in aged mice.
Guo S, Cao J, Hong G, Song Y, Xia M, Li P, Yuan W, Xiao Y, Sun G, Liu S, Cao S, Qi J, Bi X, Liu Z, Wu Y, Li W, Zhao X, Gao J, Chai R, Fu X
Nature aging 2025 May;5(5):848-867
Nature aging 2025 May;5(5):848-867
Effects of p53 on the Regulation of Carbonic Anhydrase 8 in Human Colorectal Cancer Cells: Interaction Between p53 and Sp1.
Yu JY, Hsieh BY, Tsai SF, Hsieh M
Cell biochemistry and function 2025 May;43(5):e70081
Cell biochemistry and function 2025 May;43(5):e70081
Design and Synthesis of O-Dialkylaminoalkyl Substituted Urolithin Derivatives: DNA Topoisomerase IIα Inhibition With Promising Antiproliferative Activity.
Li X, Zhang X, Yin C, Lu C, Shen Y
Archiv der Pharmazie 2025 May;358(5):e70009
Archiv der Pharmazie 2025 May;358(5):e70009
METTL3-mediated m6A modification of PAK6 drives cervical cancer progression through activating MAPK14.
Zhu ZM, Huo FC, Shi C, Li MT, Zhou Y, Zhang LS, Pei DS
International journal of biological macromolecules 2025 May;309(Pt 2):142880
International journal of biological macromolecules 2025 May;309(Pt 2):142880
An injectable multimodal thiolated carboxymethyl cellulose hydrogel for advanced gastric cancer treatment.
Wu T, Zhou J, He W, Jin L, Li T, Gong T, Liu X
International journal of biological macromolecules 2025 May;306(Pt 2):141546
International journal of biological macromolecules 2025 May;306(Pt 2):141546
Praja2 controls P-body assembly and translation in glioblastoma by non-proteolytic ubiquitylation of DDX6.
Senatore E, Avolio R, Rinaldi L, Chiuso F, Oliva MA, D'Ambrosio C, Bianco AG, Dalla E, Pagnotta SM, Flammia R, Ambrosino C, Memoli D, Turacchio G, Mimoune SI, Toiron Y, Audebert S, Camoin L, Lignitto L, Scaloni A, Arcella A, Feliciello A
EMBO reports 2025 May;26(9):2347-2377
EMBO reports 2025 May;26(9):2347-2377
Astragalin actives autophagy and inhibits apoptosis of astrocytes in AD mice via down-regulating Fas/Fasl-VDAC1 pathway.
Wang S, Yang Y, Lin J, Zhang W, Yang C, Zhang R, Zhou C, Zhang L, Wang X, Liu J, Jin X, Ma Y
Free radical biology & medicine 2025 May;232:72-85
Free radical biology & medicine 2025 May;232:72-85
Nicotine Ameliorates α-Synuclein Preformed Fibril-Induced Behavioral Deficits and Pathological Features in Mice.
Huang Z, Pan Y, Ma K, Luo H, Zong Q, Wu Z, Zhu Z, Guan Y
Applied biochemistry and biotechnology 2025 May;197(5):3026-3047
Applied biochemistry and biotechnology 2025 May;197(5):3026-3047
Toosendanin-induced liver damage through irreparable DNA damage and autophagy flow blockade.
Lin Y, Zhang J, Gao X, Wu Z, Yang L, Tian K, Lv X, Li J, Chen K, Zhang Y, Hu H, Zhu A
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156586
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156586
Lycium ruthenicum Murray Anthocyanins Alleviate Aging Through SIRT1/P53 Signaling Pathway.
Liang J, Ga Z, Wu J, Wang Y, Dongzhu N, Qieyang R, Li P, Huaqian S
International journal of molecular sciences 2025 May 9;26(10)
International journal of molecular sciences 2025 May 9;26(10)
Lithium with environmentally relevant concentrations interferes with mitochondrial function, antioxidant response, and autophagy processes in Daphnia magna, leading to changes in life-history traits and behavior.
Duan C, Zhao Y, Xiao Y, Hou Y, Gong W, Zhang H, Wang Y, Nie X
Journal of hazardous materials 2025 May 5;488:137420
Journal of hazardous materials 2025 May 5;488:137420
The mechanism of telomerase Cajal body protein 1 regulating senescence of mouse bone marrow mesenchymal stem cells.
Lin SQ, Tian N, Yao X, Pan XH, Li ZA, Wang Q, Gao J, Zhao XL, Ruan GP
Stem cell research & therapy 2025 May 30;16(1):267
Stem cell research & therapy 2025 May 30;16(1):267
SIRT2 inhibition enhances mitochondrial apoptosis in Brucella-infected bovine placental trophoblast cells.
Zhang M, Qi L, Li J, Yuan N, Zhai Y, Hao M, Zhou D, Liu W, Jin Y, Wang A
Veterinary research 2025 May 2;56(1):97
Veterinary research 2025 May 2;56(1):97
Therapeutic potential of Sweroside in postmenopausal osteoporosis: Inhibition of osteoclast differentiation and promotion of osteoclast apoptosis via NF-κB and MAPK pathways.
Wu Z, Wang J, Chen K, Yu Q, Zhou X, Wu L, Sun C
International immunopharmacology 2025 May 16;155:114630
International immunopharmacology 2025 May 16;155:114630
Bufei Yishen formula alleviates airway epithelial cell senescence in COPD by activating AMPK-Sirt1-FoxO3a pathway and promoting autophagy.
Cheng M, Yang M, Tian Y, Liu X, Li J, Zhao P
Scientific reports 2025 May 13;15(1):16584
Scientific reports 2025 May 13;15(1):16584
Targeting ADAR1 with a small molecule for the treatment of prostate cancer.
Wang X, Li J, Zhu Y, Shen H, Ding J, Zeng T, Min W, Liang SQ, Huang L, Shi Z, Shen H, Huang F, Yuan K, Kuang W, Ji M, Sun C, Hou Y, Wang L, Chen W, Jiang Y, Hao H, Xiao Y, Yang P
Nature cancer 2025 Mar;6(3):474-492
Nature cancer 2025 Mar;6(3):474-492
Liraglutide improves senescence and ameliorating diabetic sarcopenia via the YAP-TAZ pathway.
Xu Q, Qiu X, Di H, Li Z, Liu Z, Liu K
Journal of diabetes and its complications 2025 Mar;39(3):108975
Journal of diabetes and its complications 2025 Mar;39(3):108975
Investigating the role of IL-6 in the pathogenesis of systemic lupus erythematosus: Insights from bone marrow mesenchymal stem cells.
Zhang Z, Zhu S, Li Q, Wei S, Yin L, Zhu J, Yang S, Zhang W, Lai K
Lupus 2025 Mar;34(3):225-233
Lupus 2025 Mar;34(3):225-233
Overexpression of miR‑424‑5p reduces cisplatin resistance by downregulating SMURF1 in gastric cancer.
Wang D, Cui H, Yan Y, Fu W, Lu L
Oncology letters 2025 Mar;29(3):143
Oncology letters 2025 Mar;29(3):143
Anti-colorectal cancer actions of Glycyrrhiza uralensis Fisch. and its underlying mechanism via HPLC integration and network pharmacological approaches.
Duan H, Wang W, Shi Y, Wang L, Khan GJ, Luo M, Zhou J, Yang J, He C, Li F, Hu H, Zhai K
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Mar;138:156370
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Mar;138:156370
AP2A1 modulates cell states between senescence and rejuvenation.
Chantachotikul P, Liu S, Furukawa K, Deguchi S
Cellular signalling 2025 Mar;127:111616
Cellular signalling 2025 Mar;127:111616
Deficiency of ATF2 retards senescence induced by replication stress and pamidronate in mouse jaw bone marrow stem cells.
Li Y, Lin Y, Chen Z, Ji W, Liu H
Cellular signalling 2025 Mar;127:111579
Cellular signalling 2025 Mar;127:111579
α-Lipoic Acid Ameliorates Arsenic-Induced Lipid Disorders by Promoting Peroxisomal β-Oxidation and Reducing Lipophagy in Chicken Hepatocyte.
Zhao Y, Guo M, Pei T, Shang C, Chen Y, Zhao L, Lu Y, Liang C, Wang J, Zhang J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(11):e2413255
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(11):e2413255
Autologous platelet delivery of siRNAs by autologous plasma protein self-assembled nanoparticles for the treatment of acute kidney injury.
Wang J, Huang H, Jia M, Chen S, Wang F, He G, Wu C, Lou K, Zheng X, Zhang H, Qin C, Yuan Y, Zen K, Liang H
Journal of nanobiotechnology 2025 Mar 29;23(1):256
Journal of nanobiotechnology 2025 Mar 29;23(1):256
Characterization of Protein Expression and Signaling Pathway Activation That May Contribute to Differential Biological Functions in Porcine Arterial and Venous Smooth Muscle Cells.
Arteaga EC, Wai C, Uriyanghai U, Rudraraju M, Su H, Sudarsanam VA, Haddad SO, Poulton JS, Roy-Chaudhury P, Xi G
International journal of molecular sciences 2025 Mar 28;26(7)
International journal of molecular sciences 2025 Mar 28;26(7)
Increasing cisplatin exposure promotes small-cell lung cancer transformation after a shift from glucose metabolism to fatty acid metabolism.
Zhao QY, Liu WJ, Wang JG, Li H, Lv JL, Wang Y, Wang C
Journal of cancer research and clinical oncology 2025 Mar 28;151(3):126
Journal of cancer research and clinical oncology 2025 Mar 28;151(3):126
Systematically investigate the mechanism underlying the therapeutic effect of emodin in treatment of prostate cancer.
Yuan G, Mao J, Li Z
Discover oncology 2025 Mar 27;16(1):413
Discover oncology 2025 Mar 27;16(1):413
High-content screening identifies ganoderic acid A as a senotherapeutic to prevent cellular senescence and extend healthspan in preclinical models.
Chen L, Wu B, Mo L, Chen H, Yin X, Zhao Y, Cui Z, Cui F, Chen L, Deng Q, Gao C, Yao P, Li Y, Tang Y
Nature communications 2025 Mar 24;16(1):2878
Nature communications 2025 Mar 24;16(1):2878
GMCL1 Controls 53BP1 Stability and Modulates Paclitaxel Sensitivity in Cancer.
Kito Y, Gonza Lez-Robles TJ, Kaisari S, Pae J, Garcia SF, Ortiz-Pacheco J, Ueberheide B, Lehmann R, Marzio A, Rona G, Pagano M
bioRxiv : the preprint server for biology 2025 Mar 19;
bioRxiv : the preprint server for biology 2025 Mar 19;
MT1H inhibits the growth of gastric cancer by regulating SLC6A19/TTC39B/ADM2 and activating p53-dependent autophagy.
Xing Y, Li G, Li G, Xu J, Zhang T, Li M, Gao C, Fu M, Zheng P, Chu X
Scientific reports 2025 Mar 18;15(1):9339
Scientific reports 2025 Mar 18;15(1):9339
ACSS3 promotes the tumorigenesis of non-small cell lung cancer via suppressing p53-mediated ferroptosis.
Zhang J, Wang X, Wang J, Wen X, Chen S, Wang T, Wang B, Hu W
Experimental cell research 2025 Mar 15;446(2):114438
Experimental cell research 2025 Mar 15;446(2):114438
Lycopene inhibits doxorubicin-induced heart failure by inhibiting ferroptosis through the Nrf2 signaling pathway.
Huang R, Zhou C, Wang T, Chen Y, Xie Z, Wei L, Duan Y, Liao C, Ma C, Yang X
Life sciences 2025 Mar 15;365:123452
Life sciences 2025 Mar 15;365:123452
To investigate the effect and mechanism of tetrahydrocurcumin on hepatocellular carcinoma based on phosphoinositide 3-kinases/AKT signaling pathway.
Bao ZC, Liu ZD, Zhang Y, Dai HJ, Jia H, Ren F, Li N, Zhao L, Wang YW, Lv SY, Zhang Y
World journal of gastrointestinal oncology 2025 Mar 15;17(3):102187
World journal of gastrointestinal oncology 2025 Mar 15;17(3):102187
Discovery of Novel Oxazolo[4,3-f]purine Derivatives as Antitumor Agents through PPIA Interaction.
Li XJ, Zhang MC, Li X, Guan LL, Liang YR, Hao EJ, Wang Y, Guo HM
Journal of medicinal chemistry 2025 Mar 13;68(5):5573-5596
Journal of medicinal chemistry 2025 Mar 13;68(5):5573-5596
Baicalin reduced vandetanib induced myocardial injury by regulating redox balance and NLRP3 inflammasome pathway.
Wang F, Li J, Zhang Z, Huang G, Zhang X, Liu Q, Xiao W, Liu F, Sun J, Liu Y, Ma Y, Zhuang R, Du Y, Wang X, Gao C, Gu X
Tissue & cell 2025 Jun;94:102795
Tissue & cell 2025 Jun;94:102795
Aberrant activation of p53-TRIB3 axis contributes to diabetic myocardial insulin resistance and sulforaphane protection.
Lu G, Tang Y, Chen O, Guo Y, Xiao M, Wang J, Liu Q, Li J, Gao T, Zhang X, Zhang J, Cheng Q, Kuang R, Gu J
Journal of advanced research 2025 Jun;72:467-484
Journal of advanced research 2025 Jun;72:467-484
Elevation of p53 sensitizes obese kidney to adriamycin-induced aberrant lipid homeostasis via repressing HNF4α-mediated FGF21 sensitivity.
Li J, Tang Y, Lu G, Liu Q, Guo Y, Wang J, Xiao M, Gao T, Zhang X, Gu J
Journal of advanced research 2025 Jun;72:165-180
Journal of advanced research 2025 Jun;72:165-180
Natural compound PEITC inhibits gain of function of p53 mutants in cancer cells by switching YAP-binding partners between p53 and p73.
Wang YX, Wang LW, Huang Y, Zhou L, Li GY, Yang JW, Wu XF, Cheng JC, Xu Q, Shen Y
Acta pharmacologica Sinica 2025 Jun;46(6):1722-1732
Acta pharmacologica Sinica 2025 Jun;46(6):1722-1732
HNMT Promotes the Occurrence and Progression of Nasopharyngeal Carcinoma by Inhibiting the IFN/TXNIP/p53 Axis.
Cheng S, Wu XF, Sun WD, Zhai H, Liu X, Jiang CW, Ruan B
Current medical science 2025 Jun;45(3):661-670
Current medical science 2025 Jun;45(3):661-670
A novel piperine derivative HJ-23 exhibits anti-colorectal cancer effects by activating the p53 pathway.
Zhang M, Liu R, Jiang W, Li H, Zhang S, Cheng W, Ye X, He J, Liu Y, Jing A, Song Y, Wang D, Liu X, Zhang B, Wang X, Ji J
Naunyn-Schmiedeberg's archives of pharmacology 2025 Jun;398(6):7121-7131
Naunyn-Schmiedeberg's archives of pharmacology 2025 Jun;398(6):7121-7131
Fe-curcumin nanozymes-mediated reactive oxygen species scavenging and anti-apoptotic effects on age-related cataracts.
Gao X, Li K, Huang Y, Long Z, Xiang Y, Zheng W, Cheng H, Cao H, Wan W, Zheng S, Wang X, Hu K
Materials today. Bio 2025 Jun;32:101850
Materials today. Bio 2025 Jun;32:101850
Ionized Angelica polysaccharides derivatives slow tumor growth in vivo and induce the apoptosis of HepG2 cells via mitochondria death receptor-mediated pathways in vitro.
Yang Y, Wang J, Zhang Y, Xue W, Chen Y, Yue J, Wen Y, Feng R, Tan C
International journal of biological macromolecules 2025 Jun;315(Pt 1):144297
International journal of biological macromolecules 2025 Jun;315(Pt 1):144297
Qishiwei Zhenzhu Pills Protect Against Cerebral Ischemia via the P53/Cytochrome C/Apoptotic Protease Activating Factor 1-Mediated Mitochondrial Apoptosis Pathway.
Song Y, Song G, Lizhen L, Liang Y, Han M, Yang Y, Feng Q, Li Y, Zhang J, Xu M, Zeweng Y, Jiang M, Wang Z
CNS neuroscience & therapeutics 2025 Jun;31(6):e70476
CNS neuroscience & therapeutics 2025 Jun;31(6):e70476
5-HT(7)R Deficiency Alleviates ADP-Heptose-Induced Cognitive Impairment via Inhibiting Ferroptosis and Neuroinflammation in Mice.
Zou X, Yang YX, Yue BJ, Yang HY, Yang YR, Li MY, Du O, Qiao G, Wu YJ, Du JR, Long FY
CNS neuroscience & therapeutics 2025 Jun;31(6):e70455
CNS neuroscience & therapeutics 2025 Jun;31(6):e70455
Tripterygium wilfordii polyglycoside tablets attenuated the progression of hepatocellular carcinoma by targeting IL-6 and downstream signaling pathways in a multi-target manner.
Ren PY, Zhang JY, Zhao L, Sun XJ
Journal of Asian natural products research 2025 Jun;27(6):929-949
Journal of Asian natural products research 2025 Jun;27(6):929-949
Hydrogen sulfide preserves the function of senescent endothelium through SIRT2 mediated inflammatory inhibition.
Qin X, Lu F, Wan J, Teng X, Jin S, Xiao L, Xue H, Guo Q, Tian D, Wu Y
Journal of molecular and cellular cardiology 2025 Jun;203:10-21
Journal of molecular and cellular cardiology 2025 Jun;203:10-21
Taurine Alleviates Pancreatic β-Cell Senescence by Inhibition of p53 Pathway.
Wang B, Wang Z, Yang Y, Ho MYM, Yang R, Yang H, Liu S, Lin H, Cheng KKY, Li X
Journal of diabetes 2025 Jun;17(6):e70100
Journal of diabetes 2025 Jun;17(6):e70100
Antitumor/anti-inflammatory effects/tissue healing as an all-in-one therapeutic strategy for nasopharyngeal carcinoma.
Ni F, Lv H, Lin L, Zhang Y, Qiao Y, Zhang X, Li Z, Wang X, Dai X, Dong J
Journal of nanobiotechnology 2025 Jun 9;23(1):431
Journal of nanobiotechnology 2025 Jun 9;23(1):431
Polypyrrole-ferric phosphate-methotrexate nanoparticles enhance apoptosis/ferroptosis of M1 macrophages via autophagy blockage for rheumatoid arthritis treatment.
Liu H, Wan H, Zhang A, Ouyang Y, Lu X, Wu M, Hu N, Pan J, Guo D, Li ZA, Xie D
Journal of nanobiotechnology 2025 Jun 7;23(1):428
Journal of nanobiotechnology 2025 Jun 7;23(1):428
HIV Vpr activates a nucleolar-specific ATR pathway to degrade the nucleolar stress sensor CCDC137.
Nisson KA, Patel RS, Delgado Y, Bouhaddou M, Etienne L, Fregoso OI
Nucleic acids research 2025 Jun 6;53(11)
Nucleic acids research 2025 Jun 6;53(11)
The long noncoding RNA RMRP-miR-3135a-SV2A axis promotes the development of hepatocellular carcinoma.
Wang Y, Chen C, Huang H, Xu L, Tustumi F, Liu J, Li W
Journal of gastrointestinal oncology 2025 Jun 30;16(3):1060-1077
Journal of gastrointestinal oncology 2025 Jun 30;16(3):1060-1077
VIRMA-mediated m(6)A modification regulates forebrain formation through modulating ribosome biogenesis.
Wu M, Wu X, Sun H, Wang W, Zhang L, Liu X, Zhang Y, Zhang X, Liu J, Shen B, Zhou T
Science advances 2025 Jun 27;11(26):eadq9643
Science advances 2025 Jun 27;11(26):eadq9643
Ginsenoside Rh1 attenuates chondrocyte senescence and osteoarthritis via AMPK/PINK1/Parkin-mediated mitophagy.
Chen H, Zhao D, Liu S, Zhong Y, Wen Y, Chen L
International immunopharmacology 2025 Jun 26;159:114911
International immunopharmacology 2025 Jun 26;159:114911
Corneal Sensory Denervation Causes Epithelial Ferroptosis and Delayed Healing in Mice.
Wang N, Li Y, Wang X, Yang L, Zhang J, Cheng J, Jiang X, Qi X, Wei C, Zhou Q, Li Y, Li S
Investigative ophthalmology & visual science 2025 Jun 2;66(6):28
Investigative ophthalmology & visual science 2025 Jun 2;66(6):28
Charting the regulatory landscape of TP53 on transposable elements in cancer.
Qu X, Liang Y, McCornack C, Xing X, Schmidt H, Tomlinson C, Fronick C, Belter EA Jr, Macias-Velasco JF, Wang T
Genome research 2025 Jun 2;35(6):1456-1471
Genome research 2025 Jun 2;35(6):1456-1471
Chaperone-mediated autophagy directs a dual mechanism to balance premature senescence and senolysis to prevent intervertebral disc degeneration.
Cheng Z, Gao H, Shi P, Zhang A, Chen X, Chen Y, Gan W, Zhao K, Li S, Yang C, Zhang Y
Bone research 2025 Jun 12;13(1):62
Bone research 2025 Jun 12;13(1):62
Multi-omics analysis of canine aging markers and evaluation of stem cell intervention.
Li B, Ding Y, Han M, Zhang Z, Ling Z, Zhu W, Zhao X, Zhang Y, Lv C, Li N, Liao M, Hua J
Communications biology 2025 Jun 10;8(1):905
Communications biology 2025 Jun 10;8(1):905
Fate reversal: Exosome-driven macrophage rejuvenation and bacterial-responsive drug release for infection immunotherapy in diabetes.
Zou J, Cui W, Deng N, Li C, Yang W, Ye X, Yao F, Zhang T, Xiao J, Ma C, Wu L, Dong D, Chen J, Guo C, Liu A, Wu H
Journal of controlled release : official journal of the Controlled Release Society 2025 Jun 10;382:113730
Journal of controlled release : official journal of the Controlled Release Society 2025 Jun 10;382:113730
RIOK1 phase separation restricts PTEN translation via stress granules activating tumor growth in hepatocellular carcinoma.
Meng F, Li H, Huang Y, Wang C, Liu Y, Zhang C, Chen D, Zeng T, Zhang S, Li Y, Zhang B, Lang C, Xia J, Xiong W, Pan S, Sun X, Thorne RF, Liu Y, Wang J, Zhang S, Song R, Wang J, Liu L
Nature cancer 2025 Jul;6(7):1223-1241
Nature cancer 2025 Jul;6(7):1223-1241
Single-Cell and Spatial Transcriptomics Identified Fatty Acid-Binding Proteins Controlling Endothelial Glycolytic and Arterial Programming in Pulmonary Hypertension.
Liu B, Yi D, Li S, Ramirez K, Xia X, Cao Y, Zhao H, Tripathi A, Qiu S, Kala M, Rafikov R, Gu H, de Jesus Perez V, Lemay SE, Glembotski CC, Knox KS, Bonnet S, Kalinichenko VV, Zhao YY, Fallon MB, Boucherat O, Dai Z
Arteriosclerosis, thrombosis, and vascular biology 2025 Jul;45(7):1145-1165
Arteriosclerosis, thrombosis, and vascular biology 2025 Jul;45(7):1145-1165
SPATA2/CYLD Pathway-Dependent Deubiquitylation of p53 Promotes Ferroptosis in Rat Heart After Ischaemia/Reperfusion Through Suppression of SLC7A11.
Duan DQ, Li MR, Lu LQ, Yao BF, Huang LL, Luo XJ, Peng J
Heart, lung & circulation 2025 Jul;34(7):719-729
Heart, lung & circulation 2025 Jul;34(7):719-729
ZNF451 collaborates with RNF8 to regulate RNF168 localization and amplify ubiquitination signaling to promote DNA damage repair and regulate radiosensitivity.
Xu F, Xia Q, Chen B, Wang R, Zhang J, Zhao X, Zhang Z, Yao Z, Zhang J, Zhou S, Li X, Chen B, Xu A, Wu L, Zhao G
Cell death and differentiation 2025 Jul;32(7):1303-1316
Cell death and differentiation 2025 Jul;32(7):1303-1316
Mechanistic Insights Into 5'-tiRNA-His-GTG Mediated Activation of the JNK Pathway in Skin Photoaging.
Liu L, Xu Z, Dai X, Zhou X, Chen L, Luan C, Huang D, Chen H, Zhang J, Hu Y, Chen K
Aging cell 2025 Jul;24(7):e70049
Aging cell 2025 Jul;24(7):e70049
Transglutaminase 2 promotes breast cancer cell autophagy by targeting p53/ mTOR axis.
Chen J, Li M, Mao J, Wang X, Guo B, Chen X, Kalvakolanu DV, Hong J, Yang M, Liu J, Luo Q, Yang J, Sun X, Tian Y, Zhang L
Biochemical pharmacology 2025 Jul;237:116926
Biochemical pharmacology 2025 Jul;237:116926
Design, synthesis, and antitumor activity of novel thioheterocyclic nucleoside derivatives by suppressing the c-MYC pathway.
Li XJ, Huang KX, Wang KX, Liu R, Wang DC, Liang YR, Hao EJ, Wang Y, Guo HM
Acta pharmaceutica Sinica. B 2025 Jul;15(7):3685-3707
Acta pharmaceutica Sinica. B 2025 Jul;15(7):3685-3707
Synergic effect of the combination of isoliquiritigenin and arsenic trioxide in HepG2 liver cancer cells.
Li J, Gu J, Pan S, Deng N, Khan M, Li L, Wu X, Li Y
Cellular signalling 2025 Jul;131:111752
Cellular signalling 2025 Jul;131:111752
p38γ modulates ferroptosis in brain injury caused by ethanol and cerebral ischemia/reperfusion by regulating the p53/SLC7A11 signaling pathway.
Zhu X, Zhao Z, Zhang Y, Li H, Zhou X, Zhu Y, Chen Q, Kan S, Zhou L, Zhao G
Cellular signalling 2025 Jul;131:111728
Cellular signalling 2025 Jul;131:111728
Role and Mechanism of Astragalus Monomer Quercetin in Modulating Akt/Bcl-2 Pathway to Improve Ventricular Remodeling in Chronic Heart Failure.
Hu S, Lv L, Hu W
International journal of applied & basic medical research 2025 Jul-Sep;15(3):184-196
International journal of applied & basic medical research 2025 Jul-Sep;15(3):184-196
Early-life exercise extends healthspan but not lifespan in mice.
Feng M, Li M, Lou J, Wu G, Gao T, Wu F, Tan Y, Zhang N, Zhao Y, Zhao L, Li J, Shi C, Zhang X, Liu J, Gao F
Nature communications 2025 Jul 9;16(1):6328
Nature communications 2025 Jul 9;16(1):6328
A cancer persistent DNA repair circuit driven by MDM2, MDM4 (MDMX), and mutant p53 for recruitment of MDC1 and 53BP1 on chromatin.
Ellison V, Polotskaia A, Xiao G, Leybengrub P, Lee R, Qiu W, Hendrickson RC, Hu W, Bargonetti J
Nucleic acids research 2025 Jul 8;53(13)
Nucleic acids research 2025 Jul 8;53(13)
An Integrated Analysis of Transcriptomics and Metabolomics Elucidates the Role and Mechanism of TRPV4 in Blunt Cardiac Injury.
Gao L, Han L, Ma X, Wang H, Li M, Cai J
Metabolites 2025 Jul 31;15(8)
Metabolites 2025 Jul 31;15(8)
IRF2-driven upregulation of OAS3 promotes AML cell proliferation by modulating the JAK-STAT signaling pathway.
Zhang X, Zhong L, Zhai L, Li H, Liu B
Biochemical and biophysical research communications 2025 Jul 30;772:152064
Biochemical and biophysical research communications 2025 Jul 30;772:152064
Bovine lactoferrin drives cell cycle arrest and alters the transcriptomic profile of NSCLC cells.
Su J, Zhao Y, Li M, Chen G, Liu C, Idris A, Ma Z, Zhang H
Scientific reports 2025 Jul 30;15(1):27850
Scientific reports 2025 Jul 30;15(1):27850
TC2N promotes the proliferation and invasion of head and neck cancer cells with the p53-R175H.
Zhang Q, Zhou X, Hao X, Sun Q, Zhang G, Xu S
Translational cancer research 2025 Jul 30;14(7):3905-3919
Translational cancer research 2025 Jul 30;14(7):3905-3919
Terrestrosin D promotes autophagy and apoptosis of breast cancer cells through PSMD1-dependent activation of P53 pathway.
Jia LL, Wu CJ, Ye PW, Zhang Q, Liu H, Li TP, Hu XL
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156883
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156883
Curzerene suppresses epithelial-mesenchymal transition in gastric precancerous lesion cells through targeted regulation of YAP via the long non-coding RNA AFAP1-AS1.
Zhou X, Zhang C, Shen W, Zhuang R, Liu S, Liu J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156879
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156879
Molecular subtyping of endometrial carcinoma cell lines uncovers subtype-specific targetable vulnerabilities.
Li ES, Ho R, Tao R, Choi YWY, Shin CY, Chen SY, Gokbayrak B, Senz J, Yao B, Johnston L, Martin SD, Yang E, Carey MS, Hennessy BT, Huntsman DG, Klein Geltink RI, Hoang L, Wang Y
NPJ precision oncology 2025 Jul 24;9(1):254
NPJ precision oncology 2025 Jul 24;9(1):254
Design, Synthesis, and Activity Evaluation of Novel Nucleosides as ADAR1 Inhibitor for the Treatment of Prostate Cancer.
Zhu Y, Shen H, Ding J, Wang M, Ji J, Hou Y, Cai Z, Li J, Chen W, Kuang W, Wang L, Min W, Yang P, Wang X
Journal of medicinal chemistry 2025 Jul 24;68(14):14495-14513
Journal of medicinal chemistry 2025 Jul 24;68(14):14495-14513
Systematic pharmacology and experimental validation revealed the mechanism of Bupleurum chinense DC -mediated autophagy in alleviating osteoarthritis.
Wang Y, Wang C, Zhu Y, Chen K, Yu Y, Li R, Huang S, Tao T, Jiang Y
Journal of ethnopharmacology 2025 Jul 24;351:120042
Journal of ethnopharmacology 2025 Jul 24;351:120042
FGA, a new target of histone acetylation, inhibits apoptosis of granulosa cells in follicles.
Chen Y, Fang M, Duan W, Yang T, Fan H, Lv M, Zhang L, Jiang Y, Li S, Li N, Li J, Yuan X
Biological research 2025 Jul 2;58(1):43
Biological research 2025 Jul 2;58(1):43
LncRNA TMPO-AS1 facilitates cervical cancer cell tumorigenesis and ferroptosis resistance via interaction with LCN2.
Ju Y, Liu X, Na J, He J, Wu L, Wang Z, Peng C, Liao Y, Zhang Z
Scientific reports 2025 Jul 2;15(1):22604
Scientific reports 2025 Jul 2;15(1):22604
Integration of scRNA-seq and bulk tissue RNA-seq data to identify cancer-associated fibroblast-related gene RGMA as a potential treatment target for esophageal cancer.
Gao Y, Bao S, Wen B, Li H, Guo Q, Li A, Bao L, Li M, Han B
Functional & integrative genomics 2025 Jul 11;25(1):154
Functional & integrative genomics 2025 Jul 11;25(1):154
Trim65 mitigates doxorubicin-induced myocardial injury by reducing ferroptosis.
Ma X, Chen W, Hu Z, Xie L, Li Z, Liu H, Li Z, Jiang Z, Huang J, Jiang C, Huang K, Xiao S
Experimental cell research 2025 Jul 1;450(1):114613
Experimental cell research 2025 Jul 1;450(1):114613
YTHDF1 promotes p53 translation and induces ferroptosis during acute cerebral ischemia/reperfusion through m(6)A-dependent binding.
Chang X, Li B, Huang W, Chen A, Zhu S, Liu Y, Liu X, Yang J, Wang DO
Cell biology and toxicology 2025 Jul 1;41(1):112
Cell biology and toxicology 2025 Jul 1;41(1):112
A new specific GluN2B partial antagonist ameliorates brain injury caused by ischemic stroke in rats.
Fan Y, Wu H, Yin D, Liu Q, Yuan C, Zhong T, Xia B, Xiong L, Li Y, Zeng L, Li Y, Li Y, Tang L
Bioorganic chemistry 2025 Jul 1;161:108547
Bioorganic chemistry 2025 Jul 1;161:108547
The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI.
Bourgeois B, Spreitzer E, Platero-Rochart D, Paar M, Zhou Q, Usluer S, de Keizer PLJ, Burgering BMT, Sánchez-Murcia PA, Madl T
Nature communications 2025 Jul 1;16(1):5672
Nature communications 2025 Jul 1;16(1):5672
CFAP100 couples microtubule glutamylation to spindle pole integrity in keratinocytes to promote epidermal development.
Sun S, Wang Z, Xu Z, Wang Z, Sun J, Li K, Liu M, Zhao H, Liu P, Zhou J
Nature communications 2025 Jul 1;16(1):5591
Nature communications 2025 Jul 1;16(1):5591
Extracellular vesicle-derived lncRNA VIM-AS1 promotes diabetic wound healing by promoting glycolysis and alleviating cellular senescence.
Liang F, Huang N, Tian Y, Fang Y, Huang C, Qiu B, Lu T, Zheng L, Cheng J, Zhu B, Zhao J
Stem cell research & therapy 2025 Jul 1;16(1):341
Stem cell research & therapy 2025 Jul 1;16(1):341
Effects of Paeoniae Radix Rubra on lowering lipid via bioinformatics and gut microbiome.
Lin Z, Luo H, Pan S, Li Y, Zhou X, Zhao J, Xu X, Li X, Wang Y, Lv G, Lin Z, Lin H, Qi W
Scientific reports 2025 Jul 1;15(1):21117
Scientific reports 2025 Jul 1;15(1):21117
Dopamine receptor agonist pramipexole exerts neuroprotection on global cerebral ischemia/reperfusion injury by inhibiting ferroptosis.
Kang X, Wang W, Zuo Y, Wang Y, Zhang L, Liu L
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2025 Jan;34(1):108101
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2025 Jan;34(1):108101
Dynamic O-GlcNAcylation coordinates etoposide-triggered tumor cell pyroptosis by regulating p53 stability.
Wang J, Wang Y, Xiao H, Yang W, Zuo W, You Z, Wu C, Bao J
The Journal of biological chemistry 2025 Jan;301(1):108050
The Journal of biological chemistry 2025 Jan;301(1):108050
Unlocking the potential of LHPP: Inhibiting glioma growth and cell cycle via the MDM2/p53 pathway.
Guo L, Chen W, Yue J, Gao M, Zhang J, Huang Y, Xiong H, Li X, Wang Y, Yuan Y, Chen L, Fei F, Xu R
Biochimica et biophysica acta. Molecular basis of disease 2025 Jan;1871(1):167509
Biochimica et biophysica acta. Molecular basis of disease 2025 Jan;1871(1):167509
Taraxasterol regulates p53 transcriptional activity to inhibit pancreatic cancer by inducing MDM2 ubiquitination degradation.
Han A, Liu J, Du P, Li W, Quan H, Lin Z, Chen L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156298
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156298
Exosomes From Human Umbilical Cord Mesenchymal Stem Cells Alleviate Oxidative Stress-Induced POI by Regulating Autophagic Homeostasis Through the AMPK Pathway.
Chen W, Feng Q, Zhang C, Yang L, Qi J
Reproductive medicine and biology 2025 Jan-Dec;24(1):e12658
Reproductive medicine and biology 2025 Jan-Dec;24(1):e12658
USP38 exacerbates myocardial injury and malignant ventricular arrhythmias after ischemia/reperfusion by promoting ferroptosis through the P53/SLC7A11 pathway.
Gong Y, Yang H, Chen T, Zhang J, Kong B, Shuai W, Huang H
International immunopharmacology 2025 Jan 3;145:113727
International immunopharmacology 2025 Jan 3;145:113727
Discovery of Novel Small-Molecule Inhibitors Disrupting the MTDH-SND1 Protein-Protein Interaction.
Shen H, Ding J, Ji J, Hu L, Min W, Hou Y, Wang D, Chen Y, Wang L, Zhu Y, Wang X, Yang P
Journal of medicinal chemistry 2025 Jan 23;68(2):1844-1862
Journal of medicinal chemistry 2025 Jan 23;68(2):1844-1862
Comprehensive Pan-Cancer Analysis and Functional Studies Reveal SLC2A6 as a Ferroptosis Modulator in Hepatocellular carcinoma.
Yan G, Huang H, Lu Z, Chen M, Wang X, Zhong P, Qin C, Mo S, Han C, Luo X, Ye X
Scientific reports 2025 Jan 20;15(1):2545
Scientific reports 2025 Jan 20;15(1):2545
FN1 shapes the behavior of papillary thyroid carcinoma through alternative splicing of EDB region.
Liu M, Chen P, Wei B, Tan HL, Zhao YX, Ai L, Li N, Jiang YK, Lin J, Li SJ, Chang S
Scientific reports 2025 Jan 2;15(1):327
Scientific reports 2025 Jan 2;15(1):327
Revealing the role of cancer-associated fibroblast senescence in prognosis and immune landscape in pancreatic cancer.
Liu L, Huang H, Cheng B, Xie H, Peng W, Cui H, Liang J, Cao M, Yang Y, Chen W, Wang R, Zhao Y
iScience 2025 Jan 17;28(1):111612
iScience 2025 Jan 17;28(1):111612
Aberrant STING activation promotes macrophage senescence by suppressing autophagy in vascular aging from diabetes.
Ding H, Zhang Q, Yang R, Fu L, Jiang H, Zhu Q, Tai S
iScience 2025 Jan 17;28(1):111594
iScience 2025 Jan 17;28(1):111594
Interaction of STIL with FOXM1 regulates SF3A3 transcription in the hepatocellular carcinoma development.
Zhang H, Zhang L, Wu Z
Cell division 2025 Jan 17;20(1):1
Cell division 2025 Jan 17;20(1):1
RFWD2 increases proliferation and CDDP resistance of osteosarcoma cells.
Liu P, Xie N
Gene 2025 Jan 15;933:148973
Gene 2025 Jan 15;933:148973
Unc5b prevents macrophage-derived foam cell migration and promotes atherosclerotic development via the P53-cuproptosis signaling pathway.
Wang X, Geng S, Dai L, Niu Y, Chen J, Dong C, Liu R, Shi Y, Zhang J, Zhao N, Gao Z, Gao S, Yang X
Life sciences 2025 Jan 15;361:123334
Life sciences 2025 Jan 15;361:123334
Maternal exposure to deltamethrin during pregnancy and lactation impairs hippocampal learning and memory function of male offspring by ferroptosis.
Huang S, Li W, Wang D, Feng H, Wang B, Dong X, Zhao W, Liu D, Wang Y
Ecotoxicology and environmental safety 2025 Jan 15;290:117729
Ecotoxicology and environmental safety 2025 Jan 15;290:117729
Diisooctyl phthalate (DIOP) exposure leads to cell apoptosis to HUVEC cells and toxicity to Caenorhabditis elegans through increasing the oxidative stress.
Luo S, Li J, Zhou Y, Zhai Z, Li Q, Huang Z, He W, Zhong K, Kong B, Xia Z, Kwok HF, Zhu L
Ecotoxicology and environmental safety 2025 Jan 15;290:117594
Ecotoxicology and environmental safety 2025 Jan 15;290:117594
Long-chain chlorinated paraffins (LCCPs) exposure induces apoptosis in primary chicken embryo hepatocytes through oxidative stress.
Deng H, Taishi Y, Wang G, Kong Y, Zhang R, Zheng X
Ecotoxicology and environmental safety 2025 Jan 15;290:117566
Ecotoxicology and environmental safety 2025 Jan 15;290:117566
Investigation into the influence of mild hypothermia on regulating ferroptosis through the P53-SLC7A11/GPX4 signaling pathway in sepsis-induced acute lung injury.
Tao L, Xu J, Jiang L, Hu J, Tang Z
Intensive care medicine experimental 2025 Jan 15;13(1):4
Intensive care medicine experimental 2025 Jan 15;13(1):4
Gualou Xiebai Banxia Decoction suppresses cardiomyocyte apoptosis in mice after myocardial infarction through activation of acetaldehyde dehydrogenase 2.
Deng B, Zhang G, Zeng Y, Li N, Hu C, Pang M, Lu S, Gu Y, Chen G, Zhou Y, Liu Y, Hua Y
Journal of ethnopharmacology 2025 Jan 13;339:119143
Journal of ethnopharmacology 2025 Jan 13;339:119143
Naoxintong capsule accelerates mitophagy in cerebral ischemia-reperfusion injury via TP53/PINK1/PRKN pathway based on network pharmacology analysis and experimental validation.
Shang J, Wen Y, Zhang X, Huang G, Chen W, Wang B, Wu K, Xiang Q, Liu X
Journal of ethnopharmacology 2025 Jan 10;336:118721
Journal of ethnopharmacology 2025 Jan 10;336:118721
Synergistic effects of combined lead and iprodione exposure on P53 signaling-mediated hepatotoxicity, enterotoxicity and transgenerational toxicity in zebrafish.
Wang R, Deng L, Wang Y, Liu N, Yang M, Qiu J, Chen C
The Science of the total environment 2025 Jan 1;958:178127
The Science of the total environment 2025 Jan 1;958:178127
NEK2 Promotes ESCC Malignant Progression by Inhibiting Cellular Senescence via the FOXM1/c-Myc/p27 Signaling Pathway.
Li J, Wang Y, Wei S, Xu S, Dai S, Zhang L, Tian Z, Zhao L, Lv H
Molecular carcinogenesis 2025 Feb;64(2):244-259
Molecular carcinogenesis 2025 Feb;64(2):244-259
The H5N1-NS1 protein affects the host cell cycle and apoptosis through interaction with the host lncRNA PIK3CD-AS2.
Zhang M, Zeng Y, Liu Q, Li F, Zhao J, Liu Z, Liu H, Feng H
Virus genes 2025 Feb;61(1):38-53
Virus genes 2025 Feb;61(1):38-53
Antiviral mechanism of Fuzhengjiedu San against porcine reproductive and respiratory syndrome virus.
Song XQ, Zhao XY, Chen WS, Yang L, Liu DY, Chen YP
Virology 2025 Feb;603:110382
Virology 2025 Feb;603:110382
Thiostrepton suppresses colorectal cancer progression through reactive oxygen species related endoplasmic reticulum stress.
Li Z, Nie J, Zhou R, Huang H, Li X, Wang L, Lv L, Ren S, Zhao M
Toxicology and applied pharmacology 2025 Feb;495:117221
Toxicology and applied pharmacology 2025 Feb;495:117221
NUC7738 Induces Apoptosis Through Modulating Stability of P53 in Esophageal Cancer Cells.
Wu LF, Ren CH, Xu JC, Zhang YF, Liu YB, Zhou PH, Zhang YQ
Journal of biochemical and molecular toxicology 2025 Feb;39(2):e70175
Journal of biochemical and molecular toxicology 2025 Feb;39(2):e70175
Multi-omics analysis explore the mechanism of deoxynivalenol inhibiting rabbit appetite through microbial-gut-brain axis.
Yuan X, Chen W, Li R, Guo H, Wang C
Ecotoxicology and environmental safety 2025 Feb;291:117849
Ecotoxicology and environmental safety 2025 Feb;291:117849
Impaired degradation of PLCG1 by chaperone-mediated autophagy promotes cellular senescence and intervertebral disc degeneration.
Cheng Z, Gan W, Xiang Q, Zhao K, Gao H, Chen Y, Shi P, Zhang A, Li G, Song Y, Feng X, Yang C, Zhang Y
Autophagy 2025 Feb;21(2):352-373
Autophagy 2025 Feb;21(2):352-373
Integrated multiomics approach and pathological analyses provide new insights into hepatic injury and metabolic alterations in Saanen goats after dietary exposure to aflatoxin B(1).
Su D, Peng J, Hao J, Wang X, Yu P, Li S, Shi H
Journal of dairy science 2025 Feb;108(2):1431-1450
Journal of dairy science 2025 Feb;108(2):1431-1450
CB-MNCs@ CS/HEC/GP promote wound healing in aged murine pressure ulcer model.
Yang ZC, Lin H, Liu GJ, Pan H, Zhu JL, Zhang XH, Gao F, Wang Z, Wang ZH
Stem cell research & therapy 2025 Feb 7;16(1):52
Stem cell research & therapy 2025 Feb 7;16(1):52
Microbiota governs host chenodeoxycholic acid glucuronidation to ameliorate bile acid disorder induced diarrhea.
Lin Z, Feng Y, Wang J, Men Z, Ma X
Microbiome 2025 Feb 4;13(1):36
Microbiome 2025 Feb 4;13(1):36
Hsa_circ_0125356 promotes gemcitabine resistance by modulating WNT canonical and non-canonical pathways via miR-582-5p/FGF9 axis in non-small cell lung cancer.
Du X, Luo W, Li H, Gu Q, Huang P, Wang C, Li N, Liu F, Xia C
Molecular cancer 2025 Feb 27;24(1):59
Molecular cancer 2025 Feb 27;24(1):59
The inhibition of ZC3H13 attenuates G2/M arrest and apoptosis by alleviating NABP1 m6A modification in cisplatin-induced acute kidney injury.
Sheng Q, Yu Q, Lu S, Yang M, Fan X, Su H, Kong Z, Gao Y, Wang R, Lv Z
Cellular and molecular life sciences : CMLS 2025 Feb 22;82(1):86
Cellular and molecular life sciences : CMLS 2025 Feb 22;82(1):86
Exploring potential targets and mechanisms of renal tissue damage caused by N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone (6-PPDQ) through network toxicology and animal experiments: A case of chronic kidney disease.
Pei J, Peng J, Wu M, Zhan X, Wang D, Zhu G, Wang W, An N, Pan X
The Science of the total environment 2025 Feb 10;964:178626
The Science of the total environment 2025 Feb 10;964:178626
SIRT3 alleviates mitochondrial dysfunction and senescence in diabetes-associated periodontitis by deacetylating LRPPRC.
Tang H, Zhou Y, Ma L, Ye Y, Xiao QX, Tang JQ, Xu Y
Free radical biology & medicine 2025 Feb 1;227:407-419
Free radical biology & medicine 2025 Feb 1;227:407-419
Effect of the Deubiquitinating Peptidase 7 (USP7) on Hepatitis B Virus (HBV) Replication and the Antiviral Efficacy of Entecavir (ETV).
Liu Y, Pei S, Wang X, Li X, Long Y, Sun S, Meng C, Feng F
Molecular biotechnology 2025 Dec;67(12):4598-4608
Molecular biotechnology 2025 Dec;67(12):4598-4608
Propofol inhibits glioma growth by blocking the formation of the NF-κB/LGI4 feedback loop to activate TP53 self-transcription.
Wang Z, Zhang LN, Wu T, Pan X, Li L
Translational oncology 2025 Dec;62:102578
Translational oncology 2025 Dec;62:102578
Thermoradiotherapy reverses proliferation, metastasis, and anoikis resistance in glioblastoma through ITGA5-PI3K/AKT axis.
Shi Y, An H, Wang W, Nan D, Cui Y, He M, Lian J, Zhang X, Peng J, Yang X, Liu P
Translational oncology 2025 Dec;62:102552
Translational oncology 2025 Dec;62:102552
Fluorescence lifetime clocks quantify senescence and aging.
Yan C, Liu C, Liu B, Zheng Q, Zhao X, Lu S, Fu X, Li W, Li J, Li D, Yao Y, Zhang Y, Zhu H, Shi P, Zhu WH, Guo Z
Nature aging 2025 Dec;5(12):2532-2545
Nature aging 2025 Dec;5(12):2532-2545
Canagliflozin ameliorates high-salt-induced renal injury and premature aging in male Dahl salt-sensitive rats, with associated changes in SIRT6/HIF-1α signaling.
Wang Q, Liang Y, Zuo Q, He L, Zhang T, Wang Z, Zhai J, Cao B, Ma S, Zhang G, Lu F, Guo Y
Renal failure 2025 Dec;47(1):2546624
Renal failure 2025 Dec;47(1):2546624
Inhibition of matrix metalloproteinase-9 attenuates kidney fibrosis and cellular senescence in the transition from acute kidney injury to chronic kidney disease.
Shen D, Lin L, Su Y, Xu J, Jiang W, Zhang Z, Fang Y, Ding X, Xu X
Renal failure 2025 Dec;47(1):2499897
Renal failure 2025 Dec;47(1):2499897
ABI3BP deficiency alleviates Ang II-induced VSMC senescence through the Nrf2 signalling pathway.
Mao A, Tu Q, Xie H, Wang X, Liu Y, Ding Y, Cao Z
Mechanisms of ageing and development 2025 Dec;228:112104
Mechanisms of ageing and development 2025 Dec;228:112104
ALFA nanobody-guided endogenous labeling.
Wang Z, Hu F, Xue F, He W, Yuan L, Xu P
Nature chemical biology 2025 Dec;21(12):1992-2001
Nature chemical biology 2025 Dec;21(12):1992-2001
Nanovaccine loaded with seno-antigen target senescent cells to improve metabolic disorders of adipose tissue and cardiac dysfunction.
Zhang K, Yin Q, Ma Y, Cao M, Li L, Jin X, Leng J
Human vaccines & immunotherapeutics 2025 Dec;21(1):2479229
Human vaccines & immunotherapeutics 2025 Dec;21(1):2479229
Evaluation of anti-tumor activity of borated camptothecin derivatives targeting topoisomerase 1 against hepatocellular carcinoma and intrahepatic cholangiocarcinoma.
Zhang M, Xiang Y, Li C, Xu C, Chen G, Long R, Chen C, Liu Y, Ye F
Bioorganic chemistry 2025 Dec;167:109186
Bioorganic chemistry 2025 Dec;167:109186
5'tiRNA-Glu-TTC targets TRPV3 and activates the PI3K/AKT signaling pathway to modulate skin photoaging.
Xu Z, Liu L, Dai X, Zhou X, Chen L, Chen H, Luan C, Huang D, Zhang J, Hu Y, Chen K, Gu H
Non-coding RNA research 2025 Dec;15:29-43
Non-coding RNA research 2025 Dec;15:29-43
Association of TP53 and EZH2 with salivary adenoid cystic carcinoma.
Di Y, Zhang H, Zhang B, Li D
Journal of stomatology, oral and maxillofacial surgery 2025 Dec;126(6S):102526
Journal of stomatology, oral and maxillofacial surgery 2025 Dec;126(6S):102526
Lactylation-driven KRT19 promotes non-small cell lung cancer progression by suppressing cellular senescence.
Zhang C, Du Y, Ji Y, Ye X, Lian J, Zhou H, Gao Z, Xu H, Tang Y, Fan Y, Zheng L
Journal of experimental & clinical cancer research : CR 2025 Dec 4;45(1):13
Journal of experimental & clinical cancer research : CR 2025 Dec 4;45(1):13
Echinacoside as a Novel Ferroptosis Inducer in Hepatocellular Carcinoma: Mechanistic Insights from TP53/SLC7A11/GPX4 Pathway Modulation.
Wang P, Lin J, Su D
International journal of molecular sciences 2025 Dec 30;27(1)
International journal of molecular sciences 2025 Dec 30;27(1)
Identification and functional characterization of genes associated with lipopolysaccharide in lung adenocarcinoma.
Zhou S, Gao M, Dong S, Wang M, Xiao H, Shu Y, Wang X
BMC cancer 2025 Dec 3;26(1):54
BMC cancer 2025 Dec 3;26(1):54
Kaempferol inhibits atherosclerotic plaque development via dual-targeting of p53-p21-p16 senescence pathway and Nrf2/HO-1/NQO1 antioxidant mechanism: Insights from combined in vivo and in vitro research.
Cai X, Zhang Y, Zhu W, Gu N
International immunopharmacology 2025 Dec 3;166:115587
International immunopharmacology 2025 Dec 3;166:115587
TRIM47-facilitated PLK1 stabilization promotes the proliferation of liver cancer cells.
Xie T, Fan X, Yu T, Zhu Q, Zhang Q, Li N, Wang T, Qian Y, Deng K, Xin H, Li Y, Huang X
Cellular oncology (Dordrecht, Netherlands) 2025 Dec 29;49(1):7
Cellular oncology (Dordrecht, Netherlands) 2025 Dec 29;49(1):7
EXOSC3 knockdown induces G1/S phase arrest to suppress hepatocellular carcinoma cell proliferation.
Chen YM, Huo YX, Wei WS, Liu YX, Wang SH, Jiang L, Rong-He, Zhang HL, Jiang LH
Scientific reports 2025 Dec 29;15(1):44684
Scientific reports 2025 Dec 29;15(1):44684
The Ku80-p53-SIRT1 axis in DNA damage response contributes to sporadic and familial ALS and FTD.
Jun YW, Lee S, Almeida S, Freude KK, Ichida JK, Gao FB
Nature communications 2025 Dec 20;17(1):1007
Nature communications 2025 Dec 20;17(1):1007
Nicotinamide riboside alleviates sepsis-induced acute kidney injury by suppressing ferroptosis.
Fan S, Ma X, Ren T, Guo M, Wang X, Si M
Journal of molecular medicine (Berlin, Germany) 2025 Dec 20;104(1):10
Journal of molecular medicine (Berlin, Germany) 2025 Dec 20;104(1):10
Protocol for developing a mouse model of gastric cancer following Helicobacter pylori eradication and chronic ethanol feeding.
Aziz F, Dong Z
STAR protocols 2025 Dec 19;6(4):104210
STAR protocols 2025 Dec 19;6(4):104210
The SARS-CoV-2 nucleocapsid protein induces microglia senescence-mediated cognitive impairment via Glycolysis.
Yang NS, Sha HX, Zhang CY, Chen H, Liu YB, Xiong JB, Duan JX, Zhang J, Guan CX, Zhou Y, Su F, Zhong WJ
Molecular medicine (Cambridge, Mass.) 2025 Dec 12;32(1):7
Molecular medicine (Cambridge, Mass.) 2025 Dec 12;32(1):7
LAX1 as a core biomarker in Alzheimer's disease and periodontitis via the STAT signaling pathway.
Guo H, Guo T, Wang X, Bao Y, Zhang Z, Xue F, Cheng D
BMC geriatrics 2025 Dec 12;26(1):69
BMC geriatrics 2025 Dec 12;26(1):69
NSUN2 Negatively Regulates TP53 mRNA Stability to Promote the Malignant Progression of Nasopharyngeal Carcinoma.
Zheng L, Wei J, Li X, Li M, Xue C, Chen S, Wei Q, Fan S, Xiong W, Zhou M, Deng H
Cancers 2025 Dec 10;17(24)
Cancers 2025 Dec 10;17(24)
Biodentine Counteracts the Aging Process of Human Dental Pulp Stem Cells Through Wnt/β-Catenin Pathway.
Zhang Q, Cao S, Zhang M, Wu D, Zhang C, Li J
International dental journal 2025 Aug;75(4):100819
International dental journal 2025 Aug;75(4):100819
Extracellular vesicle-mediated delivery of circp53 suppresses the progression of multiple cancers by activating the CypD/TRAP/HSP90 pathway.
Yu X, Ding P, Guo M, Tang X, Wang Z, Zhang Y, Zhou L, Lv X, Shi H, Huang H, Mao J, Gu Z, Gu C, Yang Y
Experimental & molecular medicine 2025 Aug;57(8):1711-1726
Experimental & molecular medicine 2025 Aug;57(8):1711-1726
Benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide (BPDE) Induces Ferroptosis in Rat Cortical Neurons via p53-SLC7A11-ALOX12/p53-SAT1-ALOX15 Pathways.
Zhou C, Xu Z, Ding S, Li X, Wang H, He H, Sun H, Tong X, Ji T, Lyu Y, Zheng J
Journal of applied toxicology : JAT 2025 Aug;45(8):1637-1648
Journal of applied toxicology : JAT 2025 Aug;45(8):1637-1648
Synergistic effects of the curcumin analog HO-3867 and olaparib in transforming fallopian tube epithelial cells.
Tseng CC, Ku MH, Wu WM, Mendez A, Christner T, Wu YC, Huang WL, Chen YH, Huang CW, Barefoot J, Chen CW
Investigational new drugs 2025 Aug;43(4):857-873
Investigational new drugs 2025 Aug;43(4):857-873
IFI16 Induced by p53 Activates the NF-κB Pathway to Counteract Cisplatin-Induced Apoptosis in Cervical Cancer Cells.
Zhong L, Li J, Zhong J, Zhang Y, Qi H, Yu H, Li X
Journal of cellular and molecular medicine 2025 Aug;29(15):e70728
Journal of cellular and molecular medicine 2025 Aug;29(15):e70728
Role of UVA-driven cellular senescence via mTOR activation in dihydrotestosterone-induced hair loss in androgenetic alopecia mouse model.
Wei D, Zhang H, Xu W, Zhang B, Zhang L, Lan L, Li Y, Shi Y, Song X
Journal of photochemistry and photobiology. B, Biology 2025 Aug;269:113200
Journal of photochemistry and photobiology. B, Biology 2025 Aug;269:113200
Single-Cell RNA-Seq Reveals Aging-Related Impairment of Microglial Efferocytosis Contributing to Apoptotic Cells Accumulation After Retinal Injury.
Liu P, Wang Q, Wang S, Liu Y, Chen Q, Qin W, Liu X, Ye X, Jiao Y, Yuan H, Shao Z
Aging cell 2025 Aug;24(8):e70097
Aging cell 2025 Aug;24(8):e70097
Mechanism of sulforaphane in treatment of pancreatic cancer cell based on network pharmacology and in vitro experiments.
Ren Z, Feng J, Yang M, Feng D, Wang X, Liu W
Bioorganic chemistry 2025 Aug;163:108754
Bioorganic chemistry 2025 Aug;163:108754
The n-butanol extract of Polygonatum sibiricum improves spleen aging via p53 pathway.
Chao J, Wang Y, Huang Q, Zhang H, Chen Y, Cheng X, Mao J, Yu J, Yan M, Chen S, Lv G, Su J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Aug;144:156888
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Aug;144:156888
Targeting to Intensify M2 Macrophage Polarization Ameliorate Podocyte Lipid Accumulation and Damage by Tea Polyphenols via Activating SIRT1 in the Aged Model Rats With DKD.
Chen S, Wang X, Li C, Cheng L, Lv C, Xue L, Zhang C, Li X, Li M, Guo Q, Zhao Y, Zhao H
Food science & nutrition 2025 Aug;13(8):e70736
Food science & nutrition 2025 Aug;13(8):e70736
Lobaric Acid Exhibits Anticancer Potential by Modulating the Wnt/β-Catenin Signaling Pathway in MCF-7 Cells.
Kalın ŞN, Bayındırlı KN, Toraman E, Günaydın Ş, Keleş F, Altay A, Budak H
Pharmacology research & perspectives 2025 Aug;13(4):e70142
Pharmacology research & perspectives 2025 Aug;13(4):e70142
LIMK1 as a Novel Kinase of β-Catenin Promotes Esophageal Cancer Metastasis by Cooperating With CDK5.
Li SJ, Liang ZR, Liu ZC, Luo XP, Li JY, Yu XM, Huang XZ, He Y, Xu TY, Xu JJ, Peng SC, Song YX, He Y, Zhuang XW, Zheng CC, Zhang F, Lam AK, Dai W, He ML, Liu B, Zhao Q, Lu GL, Liu JB, Wang ZN, Li ZG, Liu ZX, Xu WW, Li B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(29):e03223
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(29):e03223
E2F1-autophagy-ALDH1A1 axis enhances self-renewal and drug resistance of lung cancer stem-like cells in a p53-dependent manner.
Li J, Chen Y, Wang J, Liu L, Qadir J, Xie D, Wan X, Luo Y, Xian J, Ye T
Journal of experimental & clinical cancer research : CR 2025 Aug 30;44(1):261
Journal of experimental & clinical cancer research : CR 2025 Aug 30;44(1):261
Erchen decoction alleviates silicosis by attenuating ferroptosis and fibrosis in alveolar macrophages via modulating the P53/HMOX1 pathway.
Wang Z, Lu J, Liu C, Liang X, Zeng P, Lu F
Journal of ethnopharmacology 2025 Aug 29;352:120227
Journal of ethnopharmacology 2025 Aug 29;352:120227
The long noncoding RNA lnc-FANCI-2 intrinsically restricts RAS signaling in human papillomavirus type 16-infected cervical cancer cells.
Liu H, Yu L, Majerciak V, Meyer TJ, Yi M, Johnson PF, Cam M, Lowy DR, Zheng ZM
eLife 2025 Aug 29;13
eLife 2025 Aug 29;13
Reduction of lymphotoxin beta receptor induces cellular senescence via the MDMX-p53 pathway.
Kim SY, Lee B, Lee JJ, Kwak MS, Rhee WJ, Park IH, Shin JS
Cell death discovery 2025 Aug 29;11(1):416
Cell death discovery 2025 Aug 29;11(1):416
Senescent fibroblasts secrete CTHRC1 to promote cancer stemness in hepatocellular carcinoma.
Huang H, Peng W, Zhou Q, Zhao Y, Liu L, Cui H, Liang J, Cao M, Chen W, Wang R, Chen S, Xiong S, Cheng B, Bai S
Cell communication and signaling : CCS 2025 Aug 25;23(1):379
Cell communication and signaling : CCS 2025 Aug 25;23(1):379
Advanced glycation end products induce inflammaging in periodontal ligament fibroblasts through RAGE/AKT/mTOR/glycolysis pathway.
Xiong L, Shu J, Gao H, Qin Y, Zhang Y, Chang X, Dong Q, Chen H
Acta odontologica Scandinavica 2025 Aug 21;84:479-490
Acta odontologica Scandinavica 2025 Aug 21;84:479-490
m6A-modified circZNF548 regulates exosomal miR-7108-3p to activate CD3(+)CD8(+) T cells and suppress NSCLC growth by JMY.
Zhao YL, Li YJ, Wu CX, Xie N, Li XY, Cao DC, Guo Y, Liang Y, Li YM, Xue JN, Sun HF, Wang Q, Li XH, Wang PY, Xie SY
BMC biology 2025 Aug 15;23(1):257
BMC biology 2025 Aug 15;23(1):257
Synthesis of USP5-IN-1 derivatives as novel USP5 inhibitors with potent activity against cholangiocarcinoma cells.
Hu X, Yu Z, Zhu H, Cui H, Ning F, Dai J, Zhang J, Li Y, Zhang X
Bioorganic & medicinal chemistry 2025 Aug 15;126:118213
Bioorganic & medicinal chemistry 2025 Aug 15;126:118213
MLCK inhibition induces synthetic lethality in MYC-driven cancer.
Sun Z, Wu R, Liang X, Shi T, Zhang Y, Pan Z, Zhang W, Luan X
Cancer letters 2025 Aug 10;625:217803
Cancer letters 2025 Aug 10;625:217803
Fut8 regulated Unc5b hyperfucosylation reduces macrophage emigration and accelerates atherosclerosis development via the ferroptosis pathway.
Liu R, Dai L, Jia S, Geng S, Niu Y, Chen J, Dong C, Li C, Shi Y, Wang X, Zhang J, Zhao N, Gao Z, Yang X, Gao S
Free radical biology & medicine 2025 Aug 1;235:1-14
Free radical biology & medicine 2025 Aug 1;235:1-14
Hepatocyte-Enriched miRNA-193b-3p Promotes Hepatitis B Virus Replication by Dual Activation of Viral Core Promoter Activity and Autophagy Induction by Targeting IGF-1R.
Deng Y, Zheng J, Li F, Zou H, Tian S, Zhao Z, Zeng H, Zhai Y, Deng W, Zhang J, Lu M, Jia B, Lin Y
Journal of medical virology 2025 Apr;97(4):e70330
Journal of medical virology 2025 Apr;97(4):e70330
The role of HM13 expression and its relationship to PI3K/Akt and p53 signaling pathways in colorectal cancer.
Jin X, Wang H, Wang Y
Tissue & cell 2025 Apr;93:102702
Tissue & cell 2025 Apr;93:102702
MIER2/PGC1A elicits sunitinib resistance via lipid metabolism in renal cell carcinoma.
Wei Z, Ye Y, Liu C, Wang Q, Zhang Y, Chen K, Cheng G, Zhang X
Journal of advanced research 2025 Apr;70:287-305
Journal of advanced research 2025 Apr;70:287-305
Integrative analysis of genetic variability and functional traits in lung adenocarcinoma epithelial cells via single-cell RNA sequencing, GWAS, bayesian deconvolution, and machine learning.
Gao C, Wu J, Zhong F, Yang X, Liu H, Lai J, Cai J, Mao W, Xu H
Genes & genomics 2025 Apr;47(4):435-468
Genes & genomics 2025 Apr;47(4):435-468
Elevated CD47 Expression Impairs Elimination of Photoaged Fibroblasts by Macrophages and Serves as a Potential Biomarker for Photoaging.
Xu X, Lu X, Chen X, Yao A, Lai W
Journal of cosmetic dermatology 2025 Apr;24(4):e70098
Journal of cosmetic dermatology 2025 Apr;24(4):e70098
MDM1 overexpression promotes p53 expression and cell apoptosis to enhance therapeutic sensitivity to chemoradiotherapy in patients with colorectal cancer.
Ren N, Chen H, Huang Y, Jin J, Zhang S, Yan R, Li M, Zheng L, Zou S, Li Y, Tan W, Lin D
Cancer biology & medicine 2025 Apr 8;22(3):266-83
Cancer biology & medicine 2025 Apr 8;22(3):266-83
Investigation of c-Fos/c-Jun Signaling Pathways in Periostracum Cicadae's Inhibition of EMT in Gastric Tissue.
Liang H, Jin X, He T, Zhou X, Liu Z, Gao W
Pharmaceuticals (Basel, Switzerland) 2025 Apr 7;18(4)
Pharmaceuticals (Basel, Switzerland) 2025 Apr 7;18(4)
Surfactant protein D alleviates chondrocytes senescence by upregulating SIRT3/SOD2 pathway in osteoarthritis.
Jiang H, Zhang Y, Ji P, Ming J, Li Y, Zhou Y
Molecular medicine (Cambridge, Mass.) 2025 Apr 30;31(1):161
Molecular medicine (Cambridge, Mass.) 2025 Apr 30;31(1):161
Thesium chinense Turcz. and its compound astragalin alleviate lipopolysaccharide-induced acute lung injury via the PI3K/AKT/p53 signaling pathway.
Xu H, Zhang F, Che Y, Sun T, Che K, Cui Y, Zhou N, Wan J, Chang W, Guan Y, Huang Y, Chen H
Journal of ethnopharmacology 2025 Apr 25;346:119691
Journal of ethnopharmacology 2025 Apr 25;346:119691
Development of Novel PRMT7 Inhibitors for the Treatment of Prostate Cancer.
Li J, Sun C, Zhang Y, Ding J, Yao P, Shen H, Shi Z, Wang W, Zhu Y, Kuang W, Tavus A, Wang L, Yuan K, Wang X, Yang P
Journal of medicinal chemistry 2025 Apr 24;68(8):8244-8268
Journal of medicinal chemistry 2025 Apr 24;68(8):8244-8268
Lactate shuttling links histone lactylation to adult hippocampal neurogenesis in mice.
Li Z, Liang Z, Qi H, Luo X, Wang M, Du Z, Guo W
Developmental cell 2025 Apr 21;60(8):1182-1198.e8
Developmental cell 2025 Apr 21;60(8):1182-1198.e8
Emodin alleviates the damage to lens epithelial cells in diabetic cataract by repressing the p53-mediated ferroptosis pathway.
Zuo X, Wang X, Xie J, Jia Y
International ophthalmology 2025 Apr 2;45(1):141
International ophthalmology 2025 Apr 2;45(1):141
GAMT facilitates tumor progression via inhibiting p53 in clear cell renal cell carcinoma.
Zheng B, Liu K, Feng J, Ouyang Q, Jia T, Wang Y, Tian S, Chen X, Cai T, Wen L, Zhang X, Li X, Ma X
Biology direct 2025 Apr 2;20(1):43
Biology direct 2025 Apr 2;20(1):43
Blocking triggering receptors expressed on myeloid cell-1 alleviates alveolar epithelial cell senescence by inhibiting oxidative stress in pulmonary fibrosis.
Zhong WJ, Xiong JB, Zhang CY, Jin L, Yang NS, Sha HX, Liu YB, Duan JX, Guan CX, Zhou Y, Su F
Histochemistry and cell biology 2025 Apr 16;163(1):45
Histochemistry and cell biology 2025 Apr 16;163(1):45
Artemisinin regulates cell proliferation, apoptosis, and the inflammatory response of human dental pulp stem cells through the p53 signaling pathway under LPS-induced inflammation.
Sui Y, Dong X, Tong E, Zhao C, Nie R, Meng X
International immunopharmacology 2025 Apr 16;152:114396
International immunopharmacology 2025 Apr 16;152:114396
Aging and autophagic phenotypic changes in bone marrow mesenchymal stem cells in glucocorticoid-induced osteonecrosis.
Cao R, Li H, Liu G, Yan P, Zhang J, Chen Y, Duan X, Zhao Y, Lei Y, Liu C, Guan H, Xing F, Li Y, Wang K, Kong N, Tian R, Yang P
International immunopharmacology 2025 Apr 16;152:114389
International immunopharmacology 2025 Apr 16;152:114389
Cold atmospheric plasma drives USP49/HDAC3 axis mediated ferroptosis as a novel therapeutic strategy in endometrial cancer via reinforcing lactylation dependent p53 expression.
Liu J, Li Y, Ma R, Chen Y, Wang J, Zhang L, Wang B, Zhang Z, Huang L, Zhang H, Wan J, Liu H
Journal of translational medicine 2025 Apr 15;23(1):442
Journal of translational medicine 2025 Apr 15;23(1):442
Dehydrocorydaline attenuates bleomycin-induced pulmonary fibrosis by inhibiting fibroblast activation.
He J, Yue H, Zhang S, Dong R, Zhang F, Wang X, Wang K, Zhang H, Yang D, Dong Z, Liu H
Respiratory research 2025 Apr 12;26(1):136
Respiratory research 2025 Apr 12;26(1):136
Therapeutic Targets and Natural Product Screening for Cognitive Impairments Associated with Ferroptosis in Wilson's Disease.
Wang X, Chen H, Zhang X, Shao N, Chang Z, Xie D, Zhang J
The American journal of Chinese medicine 2024;52(8):2423-2452
The American journal of Chinese medicine 2024;52(8):2423-2452
Ginsenoside Rg2 Attenuates Aging-Induced Liver Injury via Inhibiting Caspase 8-Mediated Pyroptosis, Apoptosis and Modulating Gut Microbiota.
Gao XF, Ji BY, Zhang JJ, Wang Z, Jiang S, Hu JN, Gong XJ, Zhang JT, Tsopmejio ISN, Li W
The American journal of Chinese medicine 2024;52(5):1427-1449
The American journal of Chinese medicine 2024;52(5):1427-1449
Cadmium-induced annulus fibrosus cell senescence contributes to intervertebral disc degeneration via the JNK/p53 signaling pathway.
Liu X, Zhao W, Hu M, Zhang Y, Wang J, Zhang L
Iranian journal of basic medical sciences 2024;27(5):588-595
Iranian journal of basic medical sciences 2024;27(5):588-595
Comprehensive analysis and validation reveal DEPDC1 as a potential diagnostic biomarker associated with tumor immunity in non-small-cell lung cancer.
Lv M, Li X, Yin Z, Yang H, Zhou B
PloS one 2024;19(4):e0294227
PloS one 2024;19(4):e0294227
Significant role and the underly mechanism of cullin-1 in chronic obstructive pulmonary disease.
Hao W, Lin F, Kong W, Shi H, Dong H, Guan Z, Liu G, Wang X, Wang L, Liu M, Jiang Y
Open medicine (Warsaw, Poland) 2024;19(1):20241070
Open medicine (Warsaw, Poland) 2024;19(1):20241070
Integrated Network Pharmacology and in vivo Experimental Validation Approach to Explore the Potential Antioxidant Effects of Annao Pingchong Decoction in Intracerebral Hemorrhage Rats.
Zhou X, Wang X, Li J, Zhang M, Yang Y, Lei S, He Y, Yang H, Zhou D, Guo C
Drug design, development and therapy 2024;18:699-717
Drug design, development and therapy 2024;18:699-717
Oncoproteins E6 and E7 upregulate topoisomerase I to activate the cGAS-PD-L1 pathway in cervical cancer development.
Luo Y, Niu M, Liu Y, Zhang M, Deng Y, Mu D, Xu J, Hong S
Frontiers in pharmacology 2024;15:1450875
Frontiers in pharmacology 2024;15:1450875
IDO1-mediated kynurenine production inhibits IGFBP5 signaling to promote 5-fluorouracil-induced senescence escape and chemoresistance in colorectal cancer.
Li Y, Li C, Yao X, Lv J, Li W, Fu R, Chen M, Yang P, Dai Q, Wei W, Li Z
American journal of cancer research 2024;14(9):4551-4566
American journal of cancer research 2024;14(9):4551-4566
The mitochondria‒paraspeckle axis regulates the survival of transplanted stem cells under oxidative stress conditions.
Zhao M, Liu S, Wang Y, Lv K, Lou P, Zhou P, Zhu J, Li L, Cheng J, Lu Y, Liu J
Theranostics 2024;14(4):1517-1533
Theranostics 2024;14(4):1517-1533
EMF treatment delays mesenchymal stem cells senescence during long-term in vitro expansion by modulating autophagy.
Cai W, Xiao Y, Yan J, Peng H, Tu C
Frontiers in cell and developmental biology 2024;12:1489774
Frontiers in cell and developmental biology 2024;12:1489774
Urolithin A alleviates cell senescence by inhibiting ferroptosis and enhances corneal epithelial wound healing.
Guo XX, Chang XJ, Pu Q, Li AL, Li J, Li XY
Frontiers in medicine 2024;11:1441196
Frontiers in medicine 2024;11:1441196
Reduced dynamicity and increased high-order protein assemblies in dense fibrillar component of the nucleolus under cellular senescence.
Jo M, Kim S, Park J, Chang YT, Gwon Y
Redox biology 2024 Sep;75:103279
Redox biology 2024 Sep;75:103279
Ubiquitination of p21 by E3 ligase RNF135 promotes the proliferation of human glioblastoma cells.
Gu W, Wang M, Wu Z, Cai Y
Oncology letters 2024 Sep;28(3):406
Oncology letters 2024 Sep;28(3):406
Beyond ribosomal function: RPS6 deficiency suppresses cholangiocarcinoma cell growth by disrupting alternative splicing.
Fu W, Lin Y, Bai M, Yao J, Huang C, Gao L, Mi N, Ma H, Tian L, Yue P, Zhang Y, Zhang J, Ren Y, Ding L, Dai L, Leung JW, Yuan J, Zhang W, Meng W
Acta pharmaceutica Sinica. B 2024 Sep;14(9):3931-3948
Acta pharmaceutica Sinica. B 2024 Sep;14(9):3931-3948
Daphnetin induces ferroptosis in ovarian cancer by inhibiting NAD(P)H:Quinone oxidoreductase 1 (NQO1).
Ma N, Zhang M, Hu J, Wei Z, Zhang S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155876
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155876
Catalpol alleviates heat stroke-induced liver injury in mice by downregulating the JAK/STAT signaling pathway.
Ji XY, Feng JT, Zhou ZY, Zhang YY, Ma SZ, Wang XQ, Zhang B
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155853
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155853
Integrative analysis of the transcriptome and metabolome reveals the importance of hepatokine FGF21 in liver aging.
Wang W, Qian J, Shang M, Qiao Y, Huang J, Gao X, Ye Z, Tong X, Xu K, Li X, Liu Z, Zhou L, Zheng S
Genes & diseases 2024 Sep;11(5):101161
Genes & diseases 2024 Sep;11(5):101161
Aspirin exposure coupled with hypoxia interferes energy metabolism, antioxidant and autophagic processes and causes liver injury in estuarine goby Mugilogobius chulae.
Wang Y, Zhao Y, Gong W, Hou Y, Ren J, Duan C, Zhang H, Nie X, Li J
Journal of hazardous materials 2024 Sep 5;476:135071
Journal of hazardous materials 2024 Sep 5;476:135071
YIPF2 regulates genome integrity.
Zhang X, Wang T
Cell & bioscience 2024 Sep 5;14(1):114
Cell & bioscience 2024 Sep 5;14(1):114
Deferoxamine alleviates chondrocyte senescence and osteoarthritis progression by maintaining iron homeostasis.
Guo Z, Lin Y, Liu H, Guo J, Hou L, Zhang X, Xu J, Ruan Z, Li M, Sun K, Guo F
International immunopharmacology 2024 Sep 30;139:112619
International immunopharmacology 2024 Sep 30;139:112619
Gliomedin drives gastric cancer cell proliferation and migration, correlating with a poor prognosis.
You X, Wang M, Wang X, Wang X, Cheng Y, Zhang C, Miao Q, Feng Y
Heliyon 2024 Sep 30;10(18):e38153
Heliyon 2024 Sep 30;10(18):e38153
Deletion of ASPP1 in myofibroblasts alleviates myocardial fibrosis by reducing p53 degradation.
Li S, Yang M, Zhao Y, Zhai Y, Sun C, Guo Y, Zhang X, Zhang L, Tian T, Yang Y, Pei Y, Li J, Li C, Xuan L, Li X, Zhao D, Yang H, Zhang Y, Yang B, Zhang Z, Pan Z, Lu Y
Nature communications 2024 Sep 28;15(1):8425
Nature communications 2024 Sep 28;15(1):8425
Baicalin Ameliorates Depression-like Behaviors via Inhibiting Neuroinflammation and Apoptosis in Mice.
Yi Y, Liu G, Li Y, Wang C, Zhang B, Lou H, Yu S
International journal of molecular sciences 2024 Sep 24;25(19)
International journal of molecular sciences 2024 Sep 24;25(19)
Porphyromonas gingivalis virulence factors induce toxic effects in SH-SY5Y neuroblastoma cells: GRK5 modulation as a protective strategy.
Liccardo D, Valletta A, Spagnuolo G, Vinciguerra C, Lauria MR, Perrotta A, Del Giudice C, De Luca F, Rengo G, Rengo S, Rengo C, Cannavo A
Journal of biotechnology 2024 Sep 20;393:7-16
Journal of biotechnology 2024 Sep 20;393:7-16
Novel potent molecular glue degraders against broad range of hematological cancer cell lines via multiple neosubstrates degradation.
Li P, Hu X, Fan Z, Sun S, Ran Q, Wei T, Wei P, Jiang Q, Yan J, Yang N, Jia C, Yang T, Mao Y, Cai X, Xu T, Zhao Z, Qian X, Qin W, Zhuang X, Fan F, Xiao J, Zheng Z, Li S
Journal of hematology & oncology 2024 Sep 2;17(1):77
Journal of hematology & oncology 2024 Sep 2;17(1):77
TRIM16 mitigates impaired osteogenic differentiation and antioxidant response in D-galactose-induced senescent osteoblasts.
Li K, Huang K, Lu Q, Geng W, Jiang D, Guo A
European journal of pharmacology 2024 Sep 15;979:176849
European journal of pharmacology 2024 Sep 15;979:176849
Promotion of endoplasmic reticulum retrotranslocation by overexpression of E3 ubiquitin-protein ligase synoviolin 1 reduces endoplasmic reticulum stress and preserves cone photoreceptors in cyclic nucleotide-gated channel deficiency.
Yang F, Ma H, Boye SL, Boye SE, Ding XQ
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Sep 15;38(17):e70021
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Sep 15;38(17):e70021
Da-Chai-Hu-Tang Formula inhibits the progression and metastasis in HepG2 cells through modulation of the PI3K/AKT/STAT3-induced cell cycle arrest and apoptosis.
Duan ZW, Liu Y, Zhang PP, Hu JY, Mo ZX, Liu WQ, Ma X, Zhou XH, Wang XH, Hu XH, Wei SL
Journal of ethnopharmacology 2024 Sep 15;331:118293
Journal of ethnopharmacology 2024 Sep 15;331:118293
Chitosan-Modified AgNPs Efficiently Inhibit Swine Coronavirus-Induced Host Cell Infections via Targeting the Spike Protein.
Wang D, Yin C, Bai Y, Zhou M, Wang N, Tong C, Yang Y, Liu B
Biomolecules 2024 Sep 13;14(9)
Biomolecules 2024 Sep 13;14(9)
Design and Synthesis of 7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylic Acid Derivatives as PP5 Inhibitors To Reverse Temozolomide Resistance in Glioblastoma Multiforme.
Li Z, Guo M, Gu M, Cai Z, Wu Q, Yu J, Tang M, He C, Wang Y, Sun P, You Q, Wang L
Journal of medicinal chemistry 2024 Sep 12;67(17):15691-15710
Journal of medicinal chemistry 2024 Sep 12;67(17):15691-15710
Gastrodin Alleviates Angiotensin II-Induced Hypertension and Myocardial Apoptosis via Inhibition of the PRDX2/p53 Pathway In Vivo and In Vitro.
Xu N, Xie Q, Chen Y, Li J, Zhang X, Zheng H, Cheng Y, Wu M, Shen A, Wei L, Yao M, Yang Y, Sferra TJ, Jafri A, Fang Y, Peng J
Pharmaceuticals (Basel, Switzerland) 2024 Sep 12;17(9)
Pharmaceuticals (Basel, Switzerland) 2024 Sep 12;17(9)
Krüppel-like transcription factor 14 alleviates alveolar epithelial cell senescence by inhibiting endoplasmic reticulum stress in pulmonaryfibrosis.
Zhong WJ, Zhang CY, Duan JX, Chen MR, Ping-Deng, Zhang BL, Yang NS, Sha HX, Zhang J, Xiong JB, Guan CX, Zhou Y
International journal of biological macromolecules 2024 Sep 11;280(Pt 1):135351
International journal of biological macromolecules 2024 Sep 11;280(Pt 1):135351
FABP4 deficiency ameliorates alcoholic steatohepatitis in mice via inhibition of p53 signaling pathway.
Xing H, Wu Z, Jiang K, Yuan G, Guo Z, Yu S, He S, Zhong F
Scientific reports 2024 Sep 10;14(1):21135
Scientific reports 2024 Sep 10;14(1):21135
The Long Non-Coding RNA NR3C2-8:1 Promotes p53-Mediated Apoptosis through the miR-129-5p/USP10 Axis in Amyotrophic Lateral Sclerosis.
Pang D, Yu Y, Zhao B, Huang J, Cui Y, Li T, Li C, Shang H
Molecular neurobiology 2024 Oct;61(10):7466-7480
Molecular neurobiology 2024 Oct;61(10):7466-7480
Dual targeting of wild-type p53 and gut microbiota by Magnolol represses key metabolic process and kills CRC cells.
Ji H, Qiao O, Zhang Y, Wang W, Han X, Zhang X, Liu C, Gao W
Phytotherapy research : PTR 2024 Oct;38(10):4982-4998
Phytotherapy research : PTR 2024 Oct;38(10):4982-4998
EtROP38 suppresses apoptosis of host cells infected with Eimeria tenella by inhibition of the p38MAPK pathway.
Duan BT, Zhang HY, Song ZH, Han XY, Cui KL, Xu T, Zhang Y, Zhao YJ, Lei X, Tan F, Guo LL, Yang HL, Zhang L, Bai R, Lv XL, Zheng MX
Veterinary parasitology 2024 Oct;331:110296
Veterinary parasitology 2024 Oct;331:110296
The lncRNA TPTEP1 suppresses PI3K/AKT signalling and inhibits ovarian cancer progression by interacting with PTBP1.
Feng Y, Zhang Z, Yang H, Miao F, Li Y, Zhang M, Cao Y, Li M
Journal of cellular and molecular medicine 2024 Oct;28(20):e70106
Journal of cellular and molecular medicine 2024 Oct;28(20):e70106
LTF ameliorates cartilage endplate degeneration by suppressing calcification, senescence and matrix degradation through the JAK2/STAT3 pathway.
Li T, Liu Y, Cao J, Pan C, Ding R, Zhao J, Liu J, He D, Jia J, Cheng X
Journal of cellular and molecular medicine 2024 Oct;28(19):e18267
Journal of cellular and molecular medicine 2024 Oct;28(19):e18267
Plasma-derived exosome miR-10a-5p promotes premature ovarian failure by target BDNF via the TrkB/Akt/mTOR signaling pathway.
Bao Z, Li J, Cai J, Yao S, Yang N, Yang J, Zhao B, Chen Y, Wu X
International journal of biological macromolecules 2024 Oct;277(Pt 1):134195
International journal of biological macromolecules 2024 Oct;277(Pt 1):134195
Exosomes Derived from Rejuvenated Stem Cells Inactivate NLRP3 Inflammasome and Pyroptosis of Nucleus Pulposus Cells via the Transfer of Antioxidants.
Peng S, Liu X, Chang L, Liu B, Zhang M, Mao Y, Shen X
Tissue engineering and regenerative medicine 2024 Oct;21(7):1061-1077
Tissue engineering and regenerative medicine 2024 Oct;21(7):1061-1077
Seno-antigen-pulsed dendritic cell vaccine induce anti-aging immunity to improve adipose tissue senescence and metabolic abnormalities.
Cao Y, Du X, Yu J, Wang Y, Jin X, Gu B, Yin Q
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Oct;179:117433
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Oct;179:117433
NAT10 inhibition promotes ac4C-dependent ferroptosis to counteract sorafenib resistance in nasopharyngeal carcinoma.
Xue Z, Xie H, Shan Y, Zhang L, Cheng L, Chen W, Zhu R, Zhang K, Ni H, Zhang Z, You Y, You B
Cancer science 2024 Oct;115(10):3256-3272
Cancer science 2024 Oct;115(10):3256-3272
Siwu decoction exerts a phytoestrogenic osteoprotective effect on postmenopausal osteoporosis via the estrogen receptor/phosphatidylinositol 3-kinase/serine/threonine protein kinase pathway.
Yang J, Cong N, Shi D, Chen S, Zhang Z, Zhao P
Journal of ethnopharmacology 2024 Oct 5;332:118366
Journal of ethnopharmacology 2024 Oct 5;332:118366
Human adipose and umbilical cord mesenchymal stem cell-derived extracellular vesicles mitigate photoaging via TIMP1/Notch1.
Zhang H, Xiao X, Wang L, Shi X, Fu N, Wang S, Zhao RC
Signal transduction and targeted therapy 2024 Oct 30;9(1):294
Signal transduction and targeted therapy 2024 Oct 30;9(1):294
Sensing of endogenous retroviruses-derived RNA by ZBP1 triggers PANoptosis in DNA damage and contributes to toxic side effects of chemotherapy.
Wang F, Li K, Wang W, Jiang H, He J, Cai J, Ren W, Zhao Y, Song Q, He Y, Ma Y, Feng X, Liu Y, Yu J, Jitkaew S, Ma D, Cai Z
Cell death & disease 2024 Oct 27;15(10):779
Cell death & disease 2024 Oct 27;15(10):779
HIV Protein Nef Induces Cardiomyopathy Through Induction of Bcl2 and p21.
Kondrachuk O, Ciccone P, Ford N, Hong K, Kimura Y, Zi J, Yusuf S, Alkousa A, Tailor N, Rajkumar R, Rappaport J, Gupta MK
International journal of molecular sciences 2024 Oct 23;25(21)
International journal of molecular sciences 2024 Oct 23;25(21)
Bifidobacterium lactis-Derived Vesicles Attenuate Hippocampal Neuroinflammation by Targeting IL-33 to Regulate FoxO6/P53 Signaling.
Du X, Zhang M, Wang R, Zeng Z, Zhao W, Fang B, Lan H, Hung W, Gao H
Nutrients 2024 Oct 22;16(21)
Nutrients 2024 Oct 22;16(21)
A TBK1-independent primordial function of STING in lysosomal biogenesis.
Lv B, Dion WA, Yang H, Xun J, Kim DH, Zhu B, Tan JX
Molecular cell 2024 Oct 17;84(20):3979-3996.e9
Molecular cell 2024 Oct 17;84(20):3979-3996.e9
Genome-wide RNA-Seq identifies TP53-mediated embryonic stem cells inhibiting tumor invasion and metastasis.
Li Y, Fan Y, Xie Y, Li L, Li J, Liu J, Jin Z, Xue H, Wang Z
Stem cell research & therapy 2024 Oct 16;15(1):369
Stem cell research & therapy 2024 Oct 16;15(1):369
IFN-γ induces acute graft-versus-host disease by promoting HMGB1-mediated nuclear-to-cytoplasm translocation and autophagic degradation of p53.
Wang S, Cheng T, Chen X, Zeng C, Qin W, Xu Y
Clinical science (London, England : 1979) 2024 Oct 16;138(20):1287-1304
Clinical science (London, England : 1979) 2024 Oct 16;138(20):1287-1304
TDP-43 ameliorates aging-related cartilage degradation through preventing chondrocyte senescence.
Wang L, Zhang J, Liang L, Song Z, Wang P, Ma L, Liao Z, Li N, Yang H, Li S
Experimental gerontology 2024 Oct 1;195:112546
Experimental gerontology 2024 Oct 1;195:112546
Transcriptomics reveals the mechanism of terbuthylazine-induced nephrotoxicity in chickens: Insights from AMPK/p53-mediated apoptosis perspective.
Yang Q, Ao D, Lv Y, Liu X
Pesticide biochemistry and physiology 2024 Nov;205:106171
Pesticide biochemistry and physiology 2024 Nov;205:106171
Buparlisib and ponatinib inhibit aggressiveness of cholangiocarcinoma cells via suppression of IRS1-related pathway by targeting oxidative stress resistance.
Kaewlert W, Sakonsinsiri C, Lert-Itthiporn W, Mahalapbutr P, Ali S, Rungrotmongkol T, Jusakul A, Armartmuntree N, Pairojkul C, Feng G, Ma N, Pinlaor S, Murata M, Thanan R
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Nov;180:117569
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Nov;180:117569
Cannabidiol suppresses proliferation and induces cell death, autophagy and senescence in human cholangiocarcinoma cells via the PI3K/AKT/mTOR pathway.
Pongking T, Intuyod K, Thongpon P, Thanan R, Sitthirach C, Chaidee A, Kongsintaweesuk S, Klungsaeng S, Hongsrichan N, Sakonsinsiri C, Vaeteewoottacharn K, Kanokmedhakul S, Pinlaor S, Pinlaor P
Journal of traditional and complementary medicine 2024 Nov;14(6):622-634
Journal of traditional and complementary medicine 2024 Nov;14(6):622-634
Dual-targeted halofuginone hydrobromide nanocomplexes for promotion of macrophage repolarization and apoptosis of rheumatoid arthritis fibroblast-like synoviocytes in adjuvant-induced arthritis in rats.
Zhu J, Lin Y, Li G, He Y, Su Z, Tang Y, Zhang Y, Xu Q, Yao Z, Zhou H, Liu B, Cai X
Journal of pharmaceutical analysis 2024 Nov;14(11):100981
Journal of pharmaceutical analysis 2024 Nov;14(11):100981
SNPs Give LACTB Oncogene-Like Functions and Prompt Tumor Progression via Dual-Regulating p53.
Huang G, Zhang J, Xu Y, Wu F, Fu Y, Zhang X, Yin H, You Y, Zhao P, Liu W, Shen J, Yin J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(43):e2405907
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(43):e2405907
ZNF652 exerts a tumor suppressor role in lung cancer by transcriptionally downregulating cyclin D3.
Xie C, Zhou X, Wu J, Chen W, Ren D, Zhong C, Meng Z, Shi Y, Zhu J
Cell death & disease 2024 Nov 5;15(11):792
Cell death & disease 2024 Nov 5;15(11):792
Antisenescence Expansion of Mesenchymal Stem Cells Using Piezoelectric β-Poly(vinylidene fluoride) Film-Based Culture.
Xu L, Ren W, Long Y, Yang B, Chen L, Chen W, Chen S, Cao Y, Wu D, Qu J, Li H, Yu Y, Zhang A, Wang S, Wang H, Chen T, Fan G, Li Q, Chen Z
ACS applied materials & interfaces 2024 Nov 20;16(46):63207-63224
ACS applied materials & interfaces 2024 Nov 20;16(46):63207-63224
β-Hydroxybutyrate alleviates brain aging through the MTA1 pathway in D-galactose injured mice.
Wang R, Yang X, Wang L, Wang R, Zhang W, Ji Y, Li Z, Li H, Cui L
European journal of pharmacology 2024 Nov 15;983:176959
European journal of pharmacology 2024 Nov 15;983:176959
Design of Murine Double Minute 2 Proteolysis Targeting Chimera Degraders with a Built-In Tumor-Targeting Ability.
Wang Z, Yue S, Chen X, Li J, Zhu P, Chen H, Qiu F, Xie D, Liang Y, Li D, Lu A, Liang C
Journal of medicinal chemistry 2024 Nov 14;67(21):18865-18882
Journal of medicinal chemistry 2024 Nov 14;67(21):18865-18882
FXR deficiency induced ferroptosis via modulation of the CBP-dependent p53 acetylation to suppress breast cancer growth and metastasis.
Huang P, Zhao H, Dai H, Li J, Pan X, Pan W, Xia C, Liu F
Cell death & disease 2024 Nov 14;15(11):826
Cell death & disease 2024 Nov 14;15(11):826
p53 suppresses the inflammatory response following respiratory syncytial virus infection by inhibiting TLR2.
Liu J, Gao L, Zhou N, Jiang Z, Che S, Deng Y, Zang N, Ren L, Xie X, Xie J, Liu E
Virology 2024 May;593:110018
Virology 2024 May;593:110018
LRP8 promotes tumorigenesis in ovarian cancer through inhibiting p53 signaling.
Xu Y, Zhou Y, Yi X, Nie X
Cell biology international 2024 May;48(5):626-637
Cell biology international 2024 May;48(5):626-637
Melatonin attenuates dental pulp stem cells senescence due to vitro expansion via inhibiting MMP3.
Zhang Z, Bao Y, Wei P, Yan X, Qiu Q, Qiu L
Oral diseases 2024 May;30(4):2410-2424
Oral diseases 2024 May;30(4):2410-2424
Icariin‑curcumol promotes ferroptosis in prostate cancer cells through Nrf2/HO‑1 signaling.
Sheng W, Li B, Sun T, Zhu C, Li Y, Xu W
Experimental and therapeutic medicine 2024 May;27(5):232
Experimental and therapeutic medicine 2024 May;27(5):232
Glucose-modified BSA/procyanidin C1 NPs penetrate the blood-brain barrier and alleviate neuroinflammation in Alzheimer's disease models.
Duan L, Hao Z, Ji R, Li X, Wang H, Su Y, Guan F, Ma S
International journal of biological macromolecules 2024 May;268(Pt 1):131739
International journal of biological macromolecules 2024 May;268(Pt 1):131739
METTL14 affects UVB-induced human dermal fibroblasts photoaging via miR-100-3p biogenesis in an m(6)A-dependent manner.
Chen L, Hu Y, Zhang M, Liu L, Ma J, Xu Z, Zhang J, Gu H, Chen K
Aging cell 2024 May;23(5):e14123
Aging cell 2024 May;23(5):e14123
Alkenyl oxindole is a novel PROTAC moiety that recruits the CRL4DCAF11 E3 ubiquitin ligase complex for targeted protein degradation.
Wang Y, Wei T, Zhao M, Huang A, Sun F, Chen L, Lin R, Xie Y, Zhang M, Xu S, Sun Z, Hong L, Wang R, Tian R, Li G
PLoS biology 2024 May;22(5):e3002550
PLoS biology 2024 May;22(5):e3002550
Aspirin-Mediated Acetylation of SIRT1 Maintains Intestinal Immune Homeostasis.
Xie L, Li C, Wang C, Wu Z, Wang C, Chen C, Chen X, Zhou D, Zhou Q, Lu P, Ding C, Liu CY, Lin J, Zhang X, Yu X, Yu W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 May;11(19):e2306378
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 May;11(19):e2306378
HPV oncogenes expressed from only one of multiple integrated HPV DNA copies drive clonal cell expansion in cervical cancer.
Yu L, Majerciak V, Lobanov A, Mirza S, Band V, Liu H, Cam M, Hughes SH, Lowy DR, Zheng Z-M
mBio 2024 May 8;15(5):e0072924
mBio 2024 May 8;15(5):e0072924
ABI3BP promotes renal aging through Klotho-mediated ferroptosis.
Ji R, Wei L, Zan Y, Li X, Ma S, Ma L, He X, Wang L, Ding Y
Journal of translational medicine 2024 May 29;22(1):514
Journal of translational medicine 2024 May 29;22(1):514
Salvianolic acid A alleviates H(2)O(2)-induced endothelial oxidative injury via miR-204-5p.
Qiao X, Cao S, Chen S, Guo Y, Chen N, Zheng Y, Jin B
Scientific reports 2024 May 24;14(1):11931
Scientific reports 2024 May 24;14(1):11931
Matrix stiffening promotes chondrocyte senescence and the osteoarthritis development through downregulating HDAC3.
Fu B, Shen J, Zou X, Sun N, Zhang Z, Liu Z, Zeng C, Liu H, Huang W
Bone research 2024 May 24;12(1):32
Bone research 2024 May 24;12(1):32
The activation of LBH-CRYAB signaling promotes cardiac protection against I/R injury by inhibiting apoptosis and ferroptosis.
Wu A, Zhong C, Song X, Yuan W, Tang M, Shu T, Huang H, Yang P, Liu Q
iScience 2024 May 17;27(5):109510
iScience 2024 May 17;27(5):109510
Puerarin Delays Mammary Gland Aging by Regulating Gut Microbiota and Inhibiting the p38MAPK Signaling Pathway.
Liu S, Hu H, Zhang M, Zhang Y, Geng R, Jin Y, Cao Y, Guo W, Liu J, Fu S
Journal of agricultural and food chemistry 2024 May 15;72(19):10879-10896
Journal of agricultural and food chemistry 2024 May 15;72(19):10879-10896
The Hippo pathway terminal effector TAZ/WWTR1 mediates oxaliplatin sensitivity in p53 proficient colon cancer cells.
Slaninová V, Heron-Milhavet L, Robin M, Jeanson L, Aissanou A, Kantar D, Tosi D, Bréhélin L, Gongora C, Djiane A
BMC cancer 2024 May 14;24(1):587
BMC cancer 2024 May 14;24(1):587
An Ex Vivo Aorta Culture Model to Study Vascular Cellular Senescence.
Yu Y, Bian S, Jiang Y, Li B, Cui X, Ding S, Dai Z, Chen R, Zhong W, Yuan W
Advanced biology 2024 Mar;8(3):e2300140
Advanced biology 2024 Mar;8(3):e2300140
T-2 toxin induces mitochondrial dysfunction in chondrocytes via the p53-cyclophilin D pathway.
Yu FF, Yu SY, Sun L, Zuo J, Luo KT, Wang M, Fu XL, Zhang F, Huang H, Zhou GY, Wang YJ, Ba Y
Journal of hazardous materials 2024 Mar 5;465:133090
Journal of hazardous materials 2024 Mar 5;465:133090
Metformin alleviates junctional epithelium senescence via the AMPK/SIRT1/autophagy pathway in periodontitis induced by hyperglycemia.
Ye X, Wang Y, Tian Y, Bi R, Li M, Yang C, Zhang L, Gao Y
Heliyon 2024 Mar 30;10(6):e27478
Heliyon 2024 Mar 30;10(6):e27478
Curculigoside Attenuates Endoplasmic Reticulum Stress-Induced Epithelial Cell and Fibroblast Senescence by Regulating the SIRT1-P300 Signaling Pathway.
Xie W, Deng L, Qian R, Huang X, Liu W, Tang S
Antioxidants (Basel, Switzerland) 2024 Mar 29;13(4)
Antioxidants (Basel, Switzerland) 2024 Mar 29;13(4)
Urocortin-1 promotes colorectal cancer cell migration and proliferation and inhibits apoptosis via inhibition of the p53 signaling pathway.
Guo X, Li Y, Chen X, Sun B, Guo X
Journal of cancer research and clinical oncology 2024 Mar 28;150(3):163
Journal of cancer research and clinical oncology 2024 Mar 28;150(3):163
PELI1: key players in the oncogenic characteristics of pancreatic Cancer.
Fei X, Zhu C, Liu P, Liu S, Ren L, Lu R, Hou J, Gao Y, Wang X, Pan Y
Journal of experimental & clinical cancer research : CR 2024 Mar 25;43(1):91
Journal of experimental & clinical cancer research : CR 2024 Mar 25;43(1):91
Enhancing precision medicine: a nomogram for predicting platinum resistance in epithelial ovarian cancer.
Li R, Xiong Z, Ma Y, Li Y, Yang Y, Ma S, Ha C
World journal of surgical oncology 2024 Mar 21;22(1):81
World journal of surgical oncology 2024 Mar 21;22(1):81
CircFOXO3 mediates hypoxia-induced autophagy of endometrial stromal cells in endometriosis.
Zhang L, Liu H, Xiong W, He H, Fu T, Long X, Li X, Liang J, Ding H, Xu Y, Liu Y, Dai X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Mar 15;38(5):e23515
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Mar 15;38(5):e23515
The mitochondrial UPR induced by ATF5 attenuates intervertebral disc degeneration via cooperating with mitophagy.
Xu WN, Zheng HL, Yang RZ, Sun YF, Peng BR, Liu C, Song J, Jiang SD, Zhu LX
Cell biology and toxicology 2024 Mar 13;40(1):16
Cell biology and toxicology 2024 Mar 13;40(1):16
p53-dependent HIF-1α /autophagy mediated glycolysis to support Cr(VI)-induced cell growth and cell migration.
Yang Y, Song B, Guo M, Gao J, Jiang L, Li Q, Liu Y, Cao J
Ecotoxicology and environmental safety 2024 Mar 1;272:116076
Ecotoxicology and environmental safety 2024 Mar 1;272:116076
VD(3)/VDR attenuates bisphenol A-induced impairment in mouse Leydig cells via regulation of autophagy.
Wang L, Zhuang J, Xue Z, Lu H, Zeng W, Zhang T
Journal of food science 2024 Jun;89(6):3858-3870
Journal of food science 2024 Jun;89(6):3858-3870
Photodynamic therapy inhibits cancer progression and induces ferroptosis and apoptosis by targeting P53/GPX4/SLC7A11 signaling pathways in cholangiocarcinoma.
Yan X, Li Z, Chen H, Yang F, Tian Q, Zhang Y
Photodiagnosis and photodynamic therapy 2024 Jun;47:104104
Photodiagnosis and photodynamic therapy 2024 Jun;47:104104
Gut microbiota regulates the ALK5/NOX1 axis by altering glutamine metabolism to inhibit ferroptosis of intrahepatic cholangiocarcinoma cells.
Zhang Q, Zhou J, Zhai D, Jiang Q, Yang M, Zhou M
Biochimica et biophysica acta. Molecular basis of disease 2024 Jun;1870(5):167152
Biochimica et biophysica acta. Molecular basis of disease 2024 Jun;1870(5):167152
LC-MS based metabonomics study on protective mechanism of ESWW in cerebral ischemia via CYTC/Apaf-1/NDRG4 pathway.
Liang Y, Wang F, Song Y, Tang C, Wu R, Feng Q, Han M, Li Y, Chen W, Zhang J, Jiang M, Wang Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155543
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155543
Periplcymarin targets glycolysis and mitochondrial oxidative phosphorylation of esophageal squamous cell carcinoma: Implication in anti-cancer therapy.
Han L, Xiang X, Fu Y, Wei S, Zhang C, Li L, Liu Y, Lv H, Shan B, Zhao L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155539
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155539
MaiJiTong granule attenuates atherosclerosis by reducing ferroptosis via activating STAT6-mediated inhibition of DMT1 and SOCS1/p53 pathways in LDLR(-/-) mice.
Shi J, Yang MM, Yang S, Fan F, Zheng G, Miao Y, Hua Y, Zhang J, Cheng Y, Liu S, Guo Y, Guo L, Yang X, Fan G, Ma C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155489
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jun;128:155489
Chlormequat Chloride Inhibits TM3 Leydig Cell Growth via Ferroptosis-Initiated Inflammation.
Wang X, Kang C, Guo W, Zhang H, Xiao Q, Hao W
Cells 2024 Jun 5;13(11)
Cells 2024 Jun 5;13(11)
Oncogenic HPV-induced high expression of ESM1 predicts poor prognosis and regulates aerobic glycolysis in cervical cancer.
Yuan L, Wang Y, Yu M, Feng Z, Ci M, Wang C, Chen H
iScience 2024 Jun 21;27(6):110112
iScience 2024 Jun 21;27(6):110112
Loss of the lysosomal protein CLN3 modifies the lipid content of the nuclear envelope leading to DNA damage and activation of YAP1 pro-apoptotic signaling.
Domingues N, Calcagni' A, Pires J, Freire SR, Herz NJ, Huynh T, Wieciorek K, Moreno MJ, Outeiro TF, Girão H, Milosevic I, Ballabio A, Raimundo N
bioRxiv : the preprint server for biology 2024 Jun 2;
bioRxiv : the preprint server for biology 2024 Jun 2;
Potential Molecular Mechanism of Illicium simonsii Maxim Petroleum Ether Fraction in the Treatment of Hepatocellular Carcinoma.
Zou S, Wu Y, Wen M, Liu J, Chen M, Yuan J, Zhou B
Pharmaceuticals (Basel, Switzerland) 2024 Jun 19;17(6)
Pharmaceuticals (Basel, Switzerland) 2024 Jun 19;17(6)
Integrative single-cell and bulk transcriptomes analyses reveals heterogeneity of serine-glycine-one-carbon metabolism with distinct prognoses and therapeutic vulnerabilities in HNSCC.
Wang L, Yang R, Kong Y, Zhou J, Chen Y, Li R, Chen C, Tang X, Chen X, Xia J, Chen X, Cheng B, Ren X
International journal of oral science 2024 Jun 17;16(1):44
International journal of oral science 2024 Jun 17;16(1):44
Design, synthesis and biological evaluation of indoline-maleimide conjugates as potential antitumor agents for the treatment of colorectal cancer.
Tang J, Zhang Y, Zhou L, Song X, Wei Y, Qi J, Wu J, Song Z, Zhan L
Bioorganic & medicinal chemistry 2024 Jun 15;108:117786
Bioorganic & medicinal chemistry 2024 Jun 15;108:117786
CSPG4P12 polymorphism served as a susceptibility marker for esophageal cancer in Chinese population.
Xu H, Yang Z, Hu W, Zhou X, Zhang Z, Zhang X
BMC cancer 2024 Jun 14;24(1):729
BMC cancer 2024 Jun 14;24(1):729
Hyperactivation of SREBP induces pannexin-1-dependent lytic cell death.
Xiong Y, Luo J, Hong ZY, Zhu WZ, Hu A, Song BL
Journal of lipid research 2024 Jul;65(7):100579
Journal of lipid research 2024 Jul;65(7):100579
TBK1 pharmacological inhibition mitigates osteoarthritis through attenuating inflammation and cellular senescence in chondrocytes.
Lu R, Qu Y, Wang Z, He Z, Xu S, Cheng P, Lv Z, You H, Guo F, Chen A, Zhang J, Liang S
Journal of orthopaedic translation 2024 Jul;47:207-222
Journal of orthopaedic translation 2024 Jul;47:207-222
Distinguishing high-metastasis-potential circulating tumor cells through fluidic shear stress in a bloodstream-like microfluidic circulatory system.
Li W, Guo Z, Zhou Z, Zhou Z, He H, Sun J, Zhou X, Chin YR, Zhang L, Yang M
Oncogene 2024 Jul;43(30):2295-2306
Oncogene 2024 Jul;43(30):2295-2306
RNF31 alleviates liver steatosis by promoting p53/BNIP3-related mitophagy in hepatocytes.
Chen Y, Yang F, Shi Y, Sheng J, Wang Y, Zhang L, Zhou J, Jin Y, Yan Y
Free radical biology & medicine 2024 Jul;219:163-179
Free radical biology & medicine 2024 Jul;219:163-179
MCM8 promotes gastric cancer progression through RPS15A and predicts poor prognosis.
Ding L, Sun M, Sun Y, Li J, Zhang Z, Dang S, Zhang J, Yang B, Dai Y, Zhou Q, Zhou D, Li E, Peng S, Li G
Cancer medicine 2024 Jul;13(13):e7424
Cancer medicine 2024 Jul;13(13):e7424
Formosanin C inhibits pulmonary metastasis by targeting stearyl CoA desaturase-1.
Man S, Cui Y, Shi D, Lv P, Ma L, Gao W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155689
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155689
Celastrol mediates CAV1 to attenuate pro-tumorigenic effects of senescent cells.
Zhang S, Zhu N, Shi YN, Zeng Q, Zhang CJ, Li HF, Qin L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155614
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155614
Peptide PDRPS6 attenuates myocardial ischemia injury by improving mitochondrial function.
Feng M, Zhang L, Yin A, Zhang H, Wu X, Qian L
European journal of pharmacology 2024 Jul 5;974:176570
European journal of pharmacology 2024 Jul 5;974:176570
Intragland Expression of the Shh Gene Alleviates Irradiation-Induced Salivary Gland Injury through Microvessel Protection and the Regulation of Oxidative Stress.
Hu M, Hu L, Yang T, Zhou B, Feng X, Fan Z, Shan Z
Antioxidants (Basel, Switzerland) 2024 Jul 26;13(8)
Antioxidants (Basel, Switzerland) 2024 Jul 26;13(8)
Overexpression of transcription factor TBX5 inhibits the activation of YAP1-TEAD1 pathway to promote ferroptosis in lung cancer cells.
Ma R, Hu K, Dai S, Wang Y
Biochemical and biophysical research communications 2024 Jul 23;718:150037
Biochemical and biophysical research communications 2024 Jul 23;718:150037
Flexible Sono-Piezo Patch for Functional Sweat Gland Repair through Endogenous Microenvironmental Remodeling.
Pi W, Chen H, Liu Y, Xiang J, Zhang H, Yang X, Zhang M, Cao J, Chang T, Zheng Y, Liu S, Zhang H, Han Q, Liu K, Fu X, Shao Y, Sun X
ACS nano 2024 Jul 22;
ACS nano 2024 Jul 22;
m6A-Mediated IRS1 Regulates the Development of Oral Squamous Cell Carcinoma through p53/Line-1 Signaling.
Xiao Y, Zhu X, Li Q, Wang Z, Zuo Q, Liu X, Tan J
Frontiers in bioscience (Landmark edition) 2024 Jul 19;29(7):257
Frontiers in bioscience (Landmark edition) 2024 Jul 19;29(7):257
Alphaherpesvirus manipulates retinoic acid metabolism for optimal replication.
Ming S, Zhang S, Xing J, Yang G, Zeng L, Wang J, Chu B
iScience 2024 Jul 19;27(7):110144
iScience 2024 Jul 19;27(7):110144
Circular RNA CircVmn2r1 Acts as a miR-223-3p Sponge to Promote Kidney Aging by Regulating NLRP3 Expression in Mice.
Gao F, Wei L, Li J, Zeng L, Wang M, Lan P, Liang S, Huang X, Chen L, Jiang H
The journals of gerontology. Series A, Biological sciences and medical sciences 2024 Jul 1;79(7)
The journals of gerontology. Series A, Biological sciences and medical sciences 2024 Jul 1;79(7)
Graphene oxide quantum dots-loaded sinomenine hydrochloride nanocomplexes for effective treatment of rheumatoid arthritis via inducing macrophage repolarization and arresting abnormal proliferation of fibroblast-like synoviocytes.
Lin Y, Tang Y, Yi O, Zhu J, Su Z, Li G, Zhou H, Liu L, Liu B, Cai X
Journal of nanobiotechnology 2024 Jul 1;22(1):383
Journal of nanobiotechnology 2024 Jul 1;22(1):383
TCF12 regulates the TGF-β/Smad2/3 signaling pathway to accelerate the progression of osteoarthritis by targeting CXCR4.
Zheng H, Fang J, Lu W, Liu Y, Chen S, Huang G, Zou Y, Hu S, Zheng Y, Fang H, Zhang R
Journal of orthopaedic translation 2024 Jan;44:35-46
Journal of orthopaedic translation 2024 Jan;44:35-46
Regulated secretion of mutant p53 negatively affects T lymphocytes in the tumor microenvironment.
Dong X, Li C, Deng C, Liu J, Li D, Zhou T, Yang X, Liu Y, Guo Q, Feng Y, Yu Y, Wang Z, Guo W, Zhang S, Cui H, Jiang C, Wang X, Song X, Sun X, Cao L
Oncogene 2024 Jan;43(2):92-105
Oncogene 2024 Jan;43(2):92-105
MicroRNA-10a-5p-mediated downregulation of GATA6 inhibits tumor progression in ovarian cancer.
Gao F, Wu Q, Lu D
Human cell 2024 Jan;37(1):271-284
Human cell 2024 Jan;37(1):271-284
FAXDC2 inhibits the proliferation and invasion of human liver cancer HepG2 cells.
Peng Z, Xu S, Zhang Q, Yang X, Yuan W, Wang Y, Li Y, Zhu P, Wu X, Jiang Z, Li F, Fan X
Experimental and therapeutic medicine 2024 Jan;27(1):27
Experimental and therapeutic medicine 2024 Jan;27(1):27
pH-driven preparation of pea protein isolate-curcumin nanoparticles effectively enhances antitumor activity.
Ren J, Wu H, Lu Z, Qin Q, Jiao X, Meng G, Liu W, Li G
International journal of biological macromolecules 2024 Jan;256(Pt 1):128383
International journal of biological macromolecules 2024 Jan;256(Pt 1):128383
Hydrogen sulfide inhibits alveolar type II cell senescence and limits pulmonary fibrosis via promoting MDM2-mediated p53 degradation.
Wang XL, Xu YT, Zhang SL, Zhu XY, Zhang HX, Liu YJ
Acta physiologica (Oxford, England) 2024 Jan;240(1):e14059
Acta physiologica (Oxford, England) 2024 Jan;240(1):e14059
Carfilzomib suppressed LDHA-mediated metabolic reprogramming by targeting ATF3 in esophageal squamous cell carcinoma.
Chen L, Shi H, Zhang W, Zhu Y, Chen H, Wu Z, Qi H, Liu J, Zhong M, Shi X, Wang T, Li Q
Biochemical pharmacology 2024 Jan;219:115939
Biochemical pharmacology 2024 Jan;219:115939
PKD knockdown mitigates Ang II-induced cardiac hypertrophy and ferroptosis via the JNK/P53 signaling pathway.
Lv C, Zhou L, Meng Y, Yuan H, Geng J
Cellular signalling 2024 Jan;113:110974
Cellular signalling 2024 Jan;113:110974
Rapamycin protects mouse skin from ultraviolet B-induced photodamage by modulating Hspb2-mediated autophagy and apoptosis.
Li A, Chen AJ, Xu J, Wen ZY, Bai GL, Wang ZY, Jiang YX, Wang P
Molecular biology reports 2024 Jan 6;51(1):80
Molecular biology reports 2024 Jan 6;51(1):80
A CANCER PERSISTENT DNA REPAIR CIRCUIT DRIVEN BY MDM2, MDM4 (MDMX), AND MUTANT P53 FOR RECRUITMENT OF MDC1 AND 53BP1 TO CHROMATIN.
Ellison V, Polotskaia A, Xiao G, Leybengrub P, Qiu W, Lee R, Hendrickson R, Hu W, Bargonetti J
bioRxiv : the preprint server for biology 2024 Jan 23;
bioRxiv : the preprint server for biology 2024 Jan 23;
Resveratrol protected against the development of endometriosis by promoting ferroptosis through miR-21-3p/p53/SLC7A11 signaling pathway.
Zou W, Wang X, Xia X, Zhang T, Nie M, Xiong J, Fang X
Biochemical and biophysical research communications 2024 Jan 15;692:149338
Biochemical and biophysical research communications 2024 Jan 15;692:149338
17β-Estradiol inhibits hydrogen peroxide-induced senescence and apoptosis in human umbilical vein endothelial cells by regulating the THBS1/TGF-β/Smad axis.
Lv Y, Huang Y, Fan H, Zhao Y, Ma L, Lan Y, Li C, Chen P, Lou Z, Zhou J
Molecular and cellular endocrinology 2024 Jan 15;580:112111
Molecular and cellular endocrinology 2024 Jan 15;580:112111
Traditional Chinese Medicine formula Wubi Shanyao Pills protects against reproductive aging by activating SIRT1/3 to reduce apoptosis.
Xiaohu J, Su G, Yuying Z, Simin C, Wenyan W, Jingjing Y, Meiqiu Y, Jing L, Jie S, Suhong C, Guiyuan L
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):116976
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):116976
MitomiR-1736-3p regulates copper-induced mitochondrial pathway apoptosis by inhibiting AATF in chicken hepatocytes.
Li Y, Zhong G, Li L, Li T, Li H, Li Y, Zhang H, Pan J, Hu L, Liao J, Yu W, Tang Z
The Science of the total environment 2024 Jan 1;906:167825
The Science of the total environment 2024 Jan 1;906:167825
DEPDC1B enhances malignant phenotypes of multiple myeloma through upregulating CCNB1 and inhibiting p53 signaling pathway.
Fei H, Shi X, Li S, Li Y, Yin X, Wu Z, Wang W, Shi H, Li R
Tissue & cell 2024 Feb;86:102263
Tissue & cell 2024 Feb;86:102263
USP14 promotes the proliferation of cervical cancer via upregulating β-catenin.
Song H, Qiu J, Hua K
Environmental toxicology 2024 Feb;39(2):1031-1043
Environmental toxicology 2024 Feb;39(2):1031-1043
The dual role of the DREAM/G2M pathway in non-tumorigenic immortalization of senescent cells.
Tian J, Jiang L, Li H, Dan J, Luo Y
FEBS open bio 2024 Feb;14(2):331-343
FEBS open bio 2024 Feb;14(2):331-343
Ginsenoside Rg5 inhibits lipid accumulation and hepatocyte apoptosis via the Notch1 signaling pathway in NASH mice.
Li N, Zhu C, Fu R, Ma X, Duan Z, Fan D
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155287
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Feb;124:155287
Inhibition of miR-143-3p Restores Blood-Testis Barrier Function and Ameliorates Sertoli Cell Senescence.
Xiao Z, Liang J, Huang R, Chen D, Mei J, Deng J, Wang Z, Li L, Li Z, Xia H, Yang Y, Huang Y
Cells 2024 Feb 8;13(4)
Cells 2024 Feb 8;13(4)
Discovery of Novel Antitumor Small-Molecule Agent with Dual Action of CDK2/p-RB and MDM2/p53.
Liu Z, Yang Y, Sun X, Ma R, Zhang W, Wang W, Yang G, Wang H, Zhang J, Wang Y, Tian J
Molecules (Basel, Switzerland) 2024 Feb 4;29(3)
Molecules (Basel, Switzerland) 2024 Feb 4;29(3)
Resveratrol-laden mesoporous silica nanoparticles regulate the autophagy and apoptosis via ROS-mediated p38-MAPK/HIF-1a /p53 signaling in hypertrophic scar fibroblasts.
Zuo J, Ma S
Heliyon 2024 Feb 29;10(4):e24985
Heliyon 2024 Feb 29;10(4):e24985
Integrin α(4) Positive Subpopulation in Adipose Derived Stem Cells Effectively Reduces Infarct Size through Enhanced Engraftment into Myocardial Infarction.
Yuan Z, Tan J, Wang J
International journal of stem cells 2024 Feb 28;17(1):70-79
International journal of stem cells 2024 Feb 28;17(1):70-79
SYNJ2BP ameliorates intervertebral disc degeneration by facilitating mitochondria-associated endoplasmic reticulum membrane formation and mitochondrial Zn(2+) homeostasis.
Song Y, Geng W, Zhu D, Liang H, Du Z, Tong B, Wang K, Li S, Gao Y, Feng X, Liao Z, Mei R, Yang C
Free radical biology & medicine 2024 Feb 20;212:220-233
Free radical biology & medicine 2024 Feb 20;212:220-233
Discovery of potent thiazolidin-4-one sulfone derivatives for inhibition of proliferation of osteosarcoma in vitro and in vivo.
Chen X, Luo Z, Hu Z, Sun D, He Y, Lu J, Chen L, Liu S
European journal of medicinal chemistry 2024 Feb 15;266:116082
European journal of medicinal chemistry 2024 Feb 15;266:116082
Hyperactivation of p53 contributes to mitotic catastrophe in podocytes through regulation of the Wee1/CDK1/cyclin B1 axis.
Feng J, Xie L, Lu W, Yu X, Dong H, Ma Y, Kong R
Renal failure 2024 Dec;46(2):2365408
Renal failure 2024 Dec;46(2):2365408
Macrophage polarization and macrophage-related factor expression in hypertrophy of the ligamentum flavum.
Jiang C, Wang W, Chen YL, Chen JH, Zhang ZW, Li J, Yang ZC, Li XC
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2024 Dec;33(12):4476-4487
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2024 Dec;33(12):4476-4487
Self-healing hydrogels loaded with Spatholobi Caulis alleviate disc degeneration by promoting autophagy in nucelus pulposus.
Cai S, Ding R, Zhang H, Chen Q, Yu F, Xia Y, Chen Q, Miao X, Zhou B, Chen J, Liao L, Cheng X, Fu X
Materials today. Bio 2024 Dec;29:101323
Materials today. Bio 2024 Dec;29:101323
The anti-tumor efficacy of a recombinant oncolytic herpes simplex virus mediated CRISPR/Cas9 delivery targeting in HPV16-positive cervical cancer.
Hu Z, Liu W, Liu J, Zhou H, Sun C, ChaoTian, Guo X, Zhu C, Shao M, Wang S, Wei L, Liu M, Li S, Wang J, Xu H, Zhu W, Li X, Li J
Antiviral research 2024 Dec;232:106035
Antiviral research 2024 Dec;232:106035
To explore the protective mechanism of promethazine against hippocampal neuron injury based on network pharmacology and experimental verification.
Bai L, Li F
Medicine 2024 Dec 6;103(49):e40550
Medicine 2024 Dec 6;103(49):e40550
Cyberpharmacology uncover the mechanism of the total Rhizoma Coptidis extracts ameliorate chronic atrophic gastritis.
Ma Z, Chen X, Xiong M, Wang H, Sun C, Tang W, Li J, Li X, Ma H, Ye X
Journal of ethnopharmacology 2024 Dec 5;335:118644
Journal of ethnopharmacology 2024 Dec 5;335:118644
The RIG-I-like receptor signaling pathway triggered by Staphylococcus aureus promotes breast cancer metastasis.
Zhao H, Zhang L, Du D, Mai L, Liu Y, Morigen M, Fan L
International immunopharmacology 2024 Dec 5;142(Pt B):113195
International immunopharmacology 2024 Dec 5;142(Pt B):113195
Inhibition of miR-9-3p facilitates ferroptosis by activating SAT1/p53 pathway in lung adenocarcinoma.
Wu A, Zhang A, Wang T, Chen J, Shi J
Translational lung cancer research 2024 Dec 31;13(12):3426-3442
Translational lung cancer research 2024 Dec 31;13(12):3426-3442
Synthesis, anticancer and antibacterial evaluation of novel spiramycin-acylated derivatives.
Wang Z, Cheng J, Wen H, Hou T, Luo F, Wang Y, Xu X, Liu Y, Zhao Y, Liang X
RSC advances 2024 Dec 3;14(52):38898-38907
RSC advances 2024 Dec 3;14(52):38898-38907
Ku70 silencing aggravates oxygen-glucose deprivation/reperfusion-induced injury by activation of the p53 apoptotic pathway in rat cortical astrocytes.
Xie X, Liu J
Histochemistry and cell biology 2024 Dec 23;163(1):20
Histochemistry and cell biology 2024 Dec 23;163(1):20
Taurine rescues intervertebral disc degeneration by activating mitophagy through the PINK1/Parkin pathway.
Lin S, Li T, Zhang B, Wang P
Biochemical and biophysical research communications 2024 Dec 20;739:150587
Biochemical and biophysical research communications 2024 Dec 20;739:150587
Machine learning-based prognostic model of lactylation-related genes for predicting prognosis and immune infiltration in patients with lung adenocarcinoma.
Gao M, Wang M, Zhou S, Hou J, He W, Shu Y, Wang X
Cancer cell international 2024 Dec 18;24(1):400
Cancer cell international 2024 Dec 18;24(1):400
The vitamin D receptor is essential for the replication of pseudorabies virus.
Zeng L, Wang S-Y, Du M-H, Chu B-B, Ming S-L
mBio 2024 Dec 11;15(12):e0213724
mBio 2024 Dec 11;15(12):e0213724
Novel lncRNA 803 related to Marek's disease inhibits apoptosis of DF-1 cells.
Han S, Zhao S, Ren H, Jiao Q, Wu X, Hao X, Liu M, Han L, Han L
Avian pathology : journal of the W.V.P.A 2024 Aug;53(4):229-241
Avian pathology : journal of the W.V.P.A 2024 Aug;53(4):229-241
Can thymosin beta 10 function both as a non-invasive biomarker and chemotherapeutic target in human colorectal cancer?
Yang J, Yang X, Guo T, Wang L, Zhao Z, Hu Z, Li Y
Translational oncology 2024 Aug;46:102026
Translational oncology 2024 Aug;46:102026
Baicalin protects against hepatocyte injury caused by aflatoxin B(1) via the TP53-related ferroptosis Pathway.
Zhang HJ, Luo JZ, Lan CL, Teng X, Ge B, Liu JQ, Xie HX, Yang KJ, Qin CJ, Zhou X, Peng T
Ecotoxicology and environmental safety 2024 Aug;281:116661
Ecotoxicology and environmental safety 2024 Aug;281:116661
PLCγ1 deficiency in chondrocytes accelerates the age-related changes in articular cartilage and subchondral bone.
Zhao Q, Chen X, Qu N, Qiu J, Zhang B, Xia C
Journal of cellular and molecular medicine 2024 Aug;28(16):e70027
Journal of cellular and molecular medicine 2024 Aug;28(16):e70027
Tetrastigma hemsleyanum polysaccharide combined with doxorubicin promote ferroptosis and immune function in triple-negative breast cancer.
Shang Y, Zhao M, Chen S, Chen Y, Liu X, Zhou F, Li Y, Long M, Xu K, Ding Z, Wang L
International journal of biological macromolecules 2024 Aug;275(Pt 1):133424
International journal of biological macromolecules 2024 Aug;275(Pt 1):133424
Zwitterion-Lubricated Hydrogel Microspheres Encapsulated with Metformin Ameliorate Age-Associated Osteoarthritis.
Hou J, Lin Y, Zhu C, Chen Y, Lin R, Lin H, Liu D, Guan D, Yu B, Wang J, Wu H, Cui Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(30):e2402477
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(30):e2402477
The Loss of an Orphan Nuclear Receptor NR2E3 Augments Wnt/β-catenin Signaling via Epigenetic Dysregulation that Enhances Sp1-β catenin-p300 Interactions in Hepatocellular Carcinoma.
Leung YK, Lee SG, Wang J, Guruvaiah P, Rusch NJ, Ho SM, Park C, Kim K
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(29):e2308539
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Aug;11(29):e2308539
Antitumorigenic potential of Lactobacillus-derived extracellular vesicles: p53 succinylation and glycolytic reprogramming in intestinal epithelial cells via SIRT5 modulation.
Zhang J, Huang X, Zhang T, Gu C, Zuo W, Fu L, Dong Y, Liu H
Cell biology and toxicology 2024 Aug 7;40(1):66
Cell biology and toxicology 2024 Aug 7;40(1):66
Electroacupuncture facilitates vascular normalization by inhibiting Glyoxalase1 in endothelial cells to attenuate glycolysis and angiogenesis in triple-negative breast cancer.
Wan YX, Qi XW, Lian YY, Liu ZY, Wang H, Qiu YQ, Zhang CG, Li WN, Jiang HL, Yang DH, Zhao W, Chen ZS, Huang JC
Cancer letters 2024 Aug 28;598:217094
Cancer letters 2024 Aug 28;598:217094
Annexin A1 binds PDZ and LIM domain 7 to inhibit adipogenesis and prevent obesity.
Fang L, Liu C, Jiang ZZ, Wang M, Geng K, Xu Y, Zhu Y, Fu Y, Xue J, Shan W, Zhang Q, Chen J, Chen J, Zhao M, Guo Y, Siu KWM, Chen YE, Xu Y, Liu D, Zheng L
Signal transduction and targeted therapy 2024 Aug 23;9(1):218
Signal transduction and targeted therapy 2024 Aug 23;9(1):218
Design, Synthesis, and Evaluation of p53Y220C Acetylation Targeting Chimeras (AceTACs).
Hu X, Kabir M, Lin Y, Xiong Y, Parsons RE, Gu W, Jin J
Journal of medicinal chemistry 2024 Aug 22;67(16):14633-14648
Journal of medicinal chemistry 2024 Aug 22;67(16):14633-14648
Agroprospecting of Biowastes: Globe Artichoke (Cynara scolymus L. Cultivar Tema, Asteraceae) as Potential Source of Bioactive Compounds.
Alves-Silva JM, Zuzarte M, Salgueiro L, Cocco E, Ghiani V, Falconieri D, Maccioni D, Maxia A
Molecules (Basel, Switzerland) 2024 Aug 22;29(16)
Molecules (Basel, Switzerland) 2024 Aug 22;29(16)
Two-polarized roles of transcription factor FOSB in lung cancer progression and prognosis: dependent on p53 status.
Zhang H, Zhang G, Xiao M, Cui S, Jin C, Yang J, Wu S, Lu X
Journal of experimental & clinical cancer research : CR 2024 Aug 21;43(1):237
Journal of experimental & clinical cancer research : CR 2024 Aug 21;43(1):237
METTL3 Promotes Nucleus Pulposus Cell Senescence in Intervertebral Disc Degeneration by Regulating TLR2 m6A Methylation and Gut Microbiota.
Ni S, Huang X, Li X, Shi C, Fan M, Zhao L, Rong Z, Zhang H
The journals of gerontology. Series A, Biological sciences and medical sciences 2024 Aug 1;79(8)
The journals of gerontology. Series A, Biological sciences and medical sciences 2024 Aug 1;79(8)
Pt(iv) derivatives of cisplatin and oxaliplatin bearing an EMT-related TMEM16A/COX-2-selective dual inhibitor against colorectal cancer cells HCT116.
Ma ZY, Ding XJ, Zhu ZZ, Chen Q, Wang DB, Qiao X, Xu JY
RSC medicinal chemistry 2024 Aug 1;15(9):3239-47
RSC medicinal chemistry 2024 Aug 1;15(9):3239-47
Liraglutide Protects Pancreatic Islet From Ischemic Injury by Reducing Oxidative Stress and Activating Akt Signaling During Cold Preservation to Improve Islet Transplantation Outcomes.
Cai X, Cao J, Wang L, Zou J, Li R, Sun P, Ding X, Zhang B, Liu Z, Pei X, Yang J, Zhan Y, Liu N, Liu T, Liang R, Gao J, Wang S
Transplantation 2024 Aug 1;108(8):e156-e169
Transplantation 2024 Aug 1;108(8):e156-e169
FTO ameliorates doxorubicin-induced cardiotoxicity by inhibiting ferroptosis via P53-P21/Nrf2 activation in a HuR-dependent m6A manner.
Yang Y, Ren J, Zhang J, Shi H, Wang J, Yan Y
Redox biology 2024 Apr;70:103067
Redox biology 2024 Apr;70:103067
Breast cancer cells have an increased ferroptosis risk induced by system x(c)(-) blockade after deliberately downregulating CYTL1 to mediate malignancy.
Xue W, Yu Y, Yao Y, Zhou L, Huang Y, Wang Y, Chen Z, Wang L, Li X, Wang X, Du R, Shen Y, Xu Q
Redox biology 2024 Apr;70:103034
Redox biology 2024 Apr;70:103034
Pyrogallol promotes growth arrest by activating the p53-mediated up-regulation of p21 and p62/SQSTM1-dependent degradation of β-catenin in nonsmall cell lung cancer cells.
Zhou B, Wang L, Ren Z, Liang Y, Yang S, Zhang Y, Che S, Fang W
Environmental toxicology 2024 Apr;39(4):2150-2165
Environmental toxicology 2024 Apr;39(4):2150-2165
Fusobacterium nucleatum triggers senescence phenotype in gingival epithelial cells.
Albuquerque-Souza E, Shelling B, Jiang M, Xia XJ, Rattanaprukskul K, Sahingur SE
Molecular oral microbiology 2024 Apr;39(2):29-39
Molecular oral microbiology 2024 Apr;39(2):29-39
Excess iron accumulation mediated senescence in diabetic kidney injury.
Cheng X, Li Y, Chen L, Jiang C, Peng S, Yao P, Tang Y
Journal of biochemical and molecular toxicology 2024 Apr;38(4):e23683
Journal of biochemical and molecular toxicology 2024 Apr;38(4):e23683
Integrating Network Pharmacology and Experimental Validation to Reveal the Mechanism of Vine Grape Tea Polyphenols on Hyperuricemia-Induced Renal Injury in Mice.
Li X, Li B, Meng X, Yu F, Yu X, Zhao W, Wang Y, Gao H, Cheng M, Zhong L
Journal of medicinal food 2024 Apr;27(4):312-329
Journal of medicinal food 2024 Apr;27(4):312-329
Excessive processing and acetylation of OPA1 aggravate age-related hearing loss via the dysregulation of mitochondrial dynamics.
Zhang A, Pan Y, Wang H, Ding R, Zou T, Guo D, Shen Y, Ji P, Huang W, Wen Q, Wang Q, Hu H, Wu J, Xiang M, Ye B
Aging cell 2024 Apr;23(4):e14091
Aging cell 2024 Apr;23(4):e14091
p53 accelerates endothelial cell senescence in diabetic retinopathy by enhancing FoxO3a ubiquitylation and degradation via UBE2L6.
Cheng Y, Zhang M, Xu R, Fu L, Xue M, Xu C, Tang C, Fang T, Liu X, Sun B, Chen L
Experimental gerontology 2024 Apr;188:112391
Experimental gerontology 2024 Apr;188:112391
The function of Bazhen decoction in rescuing progeroid cell senescence via facilitating G-quadruplex resolving and telomere elongation.
Li C, Yang J, Chu L, Tian J, Xiao J, Huang Y, Wang Q, Guo B, Huang L, Hu Y, Luo Y
Journal of ethnopharmacology 2024 Apr 6;323:117694
Journal of ethnopharmacology 2024 Apr 6;323:117694
Expression of Multicopy Tandem Recombinant Ginseng Hexapeptide in Bacillus subtilis and the Evaluation of Antiaging Activity.
Xiang Q, Qu L, Lei H, Duan Z, Zhu C, Yuwen W, Ma X, Fan D
Journal of agricultural and food chemistry 2024 Apr 3;72(13):7266-7278
Journal of agricultural and food chemistry 2024 Apr 3;72(13):7266-7278
DEC1 is involved in circadian rhythm disruption-exacerbated pulmonary fibrosis.
Chen SJ, Yu F, Feng X, Li Q, Jiang YH, Zhao LQ, Cheng PP, Wang M, Song LJ, Liang LM, He XL, Xiong L, Xiang F, Wang X, Ye H, Ma WL
Cell communication and signaling : CCS 2024 Apr 26;22(1):245
Cell communication and signaling : CCS 2024 Apr 26;22(1):245
Diphthamide deficiency promotes association of eEF2 with p53 to induce p21 expression and neural crest defects.
Shi Y, Huang D, Song C, Cao R, Wang Z, Wang D, Zhao L, Xu X, Lu C, Xiong F, Zhao H, Li S, Zhou Q, Luo S, Hu D, Zhang Y, Wang C, Shen Y, Su W, Wu Y, Schmitz K, Wei S, Song W
Nature communications 2024 Apr 26;15(1):3301
Nature communications 2024 Apr 26;15(1):3301
A programmable targeted protein-degradation platform for versatile applications in mammalian cells and mice.
Ma X, Yin J, Qiao L, Wan H, Liu X, Zhou Y, Wu J, Niu L, Wu M, Wang X, Ye H
Molecular cell 2024 Apr 18;84(8):1585-1600.e7
Molecular cell 2024 Apr 18;84(8):1585-1600.e7
Discovery of ganoderic acid A (GAA) PROTACs as MDM2 protein degraders for the treatment of breast cancer.
Li Y, Li G, Zuo C, Wang X, Han F, Jia Y, Shang H, Tian Y
European journal of medicinal chemistry 2024 Apr 15;270:116367
European journal of medicinal chemistry 2024 Apr 15;270:116367
Single-cell and Spatial Transcriptomics Identified Fatty Acid-binding Proteins Controlling Endothelial Glycolytic and Arterial Programming in Pulmonary Hypertension.
Liu B, Yi D, Li S, Ramirez K, Xia X, Cao Y, Zhao H, Tripathi A, Qiu S, Kala M, Rafikov R, Gu H, de Jesus Perez V, Lemay SE, Glembotski CC, Knox KS, Bonnet S, Kalinichenko VV, Zhao YY, Fallon MB, Boucherat O, Dai Z
bioRxiv : the preprint server for biology 2024 Apr 15;
bioRxiv : the preprint server for biology 2024 Apr 15;
GRAS1 non-coding RNA protects against DNA damage and cell death by binding and stabilizing NKAP.
Su T, Trang N, Zhu J, Kong L, Cheung D, Chou V, Ellis L, Huang C, Camden N, McHugh CA
bioRxiv : the preprint server for biology 2024 Apr 11;
bioRxiv : the preprint server for biology 2024 Apr 11;
A chemo/chemodynamic nanoparticle based on hyaluronic acid induces ferroptosis and apoptosis for triple-negative breast cancer therapy.
Wang N, Zhang Q, Wang Z, Liu Y, Yang S, Zhao X, Peng J
Carbohydrate polymers 2024 Apr 1;329:121795
Carbohydrate polymers 2024 Apr 1;329:121795
A Novel Myricetin Derivative with Anti-cancer Properties Induces Cell Cycle Arrest and Apoptosis in A549 Cells.
Zhou H, Xu L, Shi Y, Gu S, Wu N, Liu F, Huang Y, Qian Z, Xue W, Wang X, Chen F
Biological & pharmaceutical bulletin 2023;46(1):42-51
Biological & pharmaceutical bulletin 2023;46(1):42-51
Hypoxia-induced long non-coding RNA LINC00460 promotes p53 mediated proliferation and metastasis of pancreatic cancer by regulating the miR-4689/UBE2V1 axis and sequestering USP10.
Zhang R, Wang X, Ying X, Huang Y, Zhai S, Shi M, Tang X, Liu J, Shi Y, Li F, Wang W, Deng X
International journal of medical sciences 2023;20(10):1339-1357
International journal of medical sciences 2023;20(10):1339-1357
Crosstalk between PML and p53 in response to TGF-β1: A new mechanism of cardiac fibroblast activation.
Huang D, Zhao D, Li M, Chang SY, Xue YD, Xu N, Li SJ, Tang NN, Gong LL, Liu YN, Yu H, Li QS, Li PY, Liu JL, Chen HX, Liu MB, Zhang WY, Zhao XM, Lang XZ, Li ZD, Liu Y, Ma ZY, Li JM, Wang N, Tian H, Cai BZ
International journal of biological sciences 2023;19(3):994-1006
International journal of biological sciences 2023;19(3):994-1006
Direct targeting of sEH with alisol B alleviated the apoptosis, inflammation, and oxidative stress in cisplatin-induced acute kidney injury.
Zhang J, Luan ZL, Huo XK, Zhang M, Morisseau C, Sun CP, Hammock BD, Ma XC
International journal of biological sciences 2023;19(1):294-310
International journal of biological sciences 2023;19(1):294-310
Differential effects of WRAP53 transcript variants on non-small cell lung cancer cell behaviors.
Zhu Y, Sun W, Jiang X, Bai R, Luo Y, Gao Y, Li S, Huang Z, Gong Y, Xie C
PloS one 2023;18(1):e0281132
PloS one 2023;18(1):e0281132
Sarcoma protein kinase inhibition alleviates liver fibrosis by promoting hepatic stellate cells ferroptosis.
Cheng Z, Zhang X, Chen P, Wang H, Wang K, Shen Y
Open life sciences 2023;18(1):20220781
Open life sciences 2023;18(1):20220781
Integrating Network Pharmacology and Experimental Validation to Explore the Pharmacological Mechanism of Astragaloside IV in Treating Bleomycin-Induced Pulmonary Fibrosis.
Yuan S, Zuo B, Zhou SC, Wang M, Tan KY, Chen ZW, Cao WF
Drug design, development and therapy 2023;17:1289-1302
Drug design, development and therapy 2023;17:1289-1302
Esomeprazole Alleviates Cisplatin Resistance by Inhibiting the AKT/mTOR Pathway in Ovarian Cancer Cells.
Duan J, Zhang Z, Du J, Zhang J, Li M, Li C
OncoTargets and therapy 2023;16:425-440
OncoTargets and therapy 2023;16:425-440
DNAJC8: a prognostic marker and potential therapeutic target for hepatocellular carcinoma.
Zhang Z, Ju M, Tang Z, He Z, Hua S
Frontiers in immunology 2023;14:1289548
Frontiers in immunology 2023;14:1289548
Simultaneous suppression of PKM2 and PHGDH elicits synergistic anti-cancer effect in NSCLC.
Wang K, Lu H, Wang X, Liu Q, Hu J, Liu Y, Jin M, Kong D
Frontiers in pharmacology 2023;14:1200538
Frontiers in pharmacology 2023;14:1200538
Reactivation of mutant p53 in esophageal squamous cell carcinoma by isothiocyanate inhibits tumor growth.
Guan L, Yang Y, Lu Y, Chen Y, Luo X, Xin D, Meng X, Shan Z, Jiang G, Wang F
Frontiers in pharmacology 2023;14:1141420
Frontiers in pharmacology 2023;14:1141420
NPM1 promotes nasopharyngeal carcinoma metastasis and stemness by recruiting Mdm2 to induce the ubiquitination-mediated degradation of p53.
Hu L, Gong P, Zhou N, Wang S, He C, Zhou Y, Li Q, Zhao X, Peng H
American journal of cancer research 2023;13(5):1766-1785
American journal of cancer research 2023;13(5):1766-1785
miR-186-ANXA9 signaling inhibits tumorigenesis in breast cancer.
Wang Z, Zhou X, Deng X, Ye D, Liu D, Zhou B, Zheng W, Wang X, Wang Y, Borkhuu O, Fang L
Frontiers in oncology 2023;13:1166666
Frontiers in oncology 2023;13:1166666
ZNF655 promotes the progression of hepatocellular carcinoma through PSMB8.
Fan S, Liu Y, Lin Z, Zhang Y, Zhang N, Zhao Y, Zhou J, Mao A, Wang L, Feng Y, He X, Wang L, Pan Q
Cell biology international 2023 Sep;47(9):1535-1546
Cell biology international 2023 Sep;47(9):1535-1546
Bazi Bushen alleviates skin senescence by orchestrating skin homeostasis in SAMP6 mice.
Xu Z, Gong B, Li Z, Wang Y, Zhao Z, Xie L, Peng Y, Zhao S, Zhou H, Bian Y
Journal of cellular and molecular medicine 2023 Sep;27(18):2651-2660
Journal of cellular and molecular medicine 2023 Sep;27(18):2651-2660
Aerobic exercise enhances mitochondrial homeostasis to counteract D-galactose-induced sarcopenia in zebrafish.
Chen ZL, Guo C, Zou YY, Feng C, Yang DX, Sun CC, Wen W, Jian ZJ, Zhao Z, Xiao Q, Zheng L, Peng XY, Zhou ZQ, Tang CF
Experimental gerontology 2023 Sep;180:112265
Experimental gerontology 2023 Sep;180:112265
miR-656-3p inhibits melanomas in vitro and in vivo by inducing senescence via inhibiting LMNB2.
Sun J, Lui K, Pang Q, Xu M, Zhao H, Shao J, Yu Y, Chu X, Liang Y, Xu J, Shen Z
Journal of cancer research and clinical oncology 2023 Sep;149(12):10781-10796
Journal of cancer research and clinical oncology 2023 Sep;149(12):10781-10796
Apatinib combined with olaparib induces ferroptosis via a p53-dependent manner in ovarian cancer.
Yue W, Yupeng G, Jun C, Kui J
Journal of cancer research and clinical oncology 2023 Sep;149(11):8681-8689
Journal of cancer research and clinical oncology 2023 Sep;149(11):8681-8689
Novel flavonoid 1,3,4-oxadiazole derivatives ameliorate MPTP-induced Parkinson's disease via Nrf2/NF-κB signaling pathway.
Meng HW, Shen ZB, Meng XS, Leng-Wei, Yin ZQ, Wang XR, Zou TF, Liu ZG, Wang TX, Zhang S, Chen YL, Yang XX, Li QS, Duan YJ
Bioorganic chemistry 2023 Sep;138:106654
Bioorganic chemistry 2023 Sep;138:106654
Characterization of a Human Gastrointestinal Stromal Tumor Cell Line Established by SV40LT-Mediated Immortalization.
Hu X, Su P, Liu B, Guo J, Wang Z, He C, Wang Z, Kou Y
International journal of molecular sciences 2023 Sep 4;24(17)
International journal of molecular sciences 2023 Sep 4;24(17)
miR-491-5p regulates the susceptibility of glioblastoma to ferroptosis through TP53.
Jie XF, Li YP, Liu S, Fu Y, Xiong YY
Biochemical and biophysical research communications 2023 Sep 3;671:309-317
Biochemical and biophysical research communications 2023 Sep 3;671:309-317
Nephroprotective Effects of Cardamonin on Renal Ischemia Reperfusion Injury/UUO-Induced Renal Fibrosis.
Zhang B, Chen ZY, Jiang Z, Huang S, Liu XH, Wang L
Journal of agricultural and food chemistry 2023 Sep 13;71(36):13284-13303
Journal of agricultural and food chemistry 2023 Sep 13;71(36):13284-13303
Serum response factor activates peroxidasin transcription to block senescence of hepatic stellate cells.
Guo Y, Zhou A, Zhang Y, Chen Y, Chen Y, Gao Y, Miao X
Life sciences 2023 Sep 1;328:121824
Life sciences 2023 Sep 1;328:121824
Pregnane X receptor activation alleviates renal fibrosis in mice via interacting with p53 and inhibiting the Wnt7a/β-catenin signaling.
Ming WH, Luan ZL, Yao Y, Liu HC, Hu SY, Du CX, Zhang C, Zhao YH, Huang YZ, Sun XW, Qiao RF, Xu H, Guan YF, Zhang XY
Acta pharmacologica Sinica 2023 Oct;44(10):2075-2090
Acta pharmacologica Sinica 2023 Oct;44(10):2075-2090
Electroacupuncture inhibits hippocampal neuronal apoptosis and improves cognitive dysfunction in mice with vascular dementia via the JNK signaling pathway.
Liu Y, Yan Z, Ren Y, Wang W, Ke Y, Wang Y, Qi R
Acupuncture in medicine : journal of the British Medical Acupuncture Society 2023 Oct;41(5):284-296
Acupuncture in medicine : journal of the British Medical Acupuncture Society 2023 Oct;41(5):284-296
Polystyrene nanoplastics induce haematotoxicity with cell oxeiptosis and senescence involved in C57BL/6J mice.
Guo X, Cheng C, Wang L, Li D, Fan R, Wei X
Environmental toxicology 2023 Oct;38(10):2487-2498
Environmental toxicology 2023 Oct;38(10):2487-2498
Improved anti-tumor activity of fluorinated camptothecin derivatives 9-fluorocamptothecin and 7-ethyl-9-fluorocamptothecin on hepatocellular carcinoma by targeting topoisomerase I.
Zhang M, Zhu LZ, Yang CJ, Yan JX, Wang ZP, Bai YP, Peng LZ, Luo HB, Zhang ZJ, Li L, Xu CR, Liu YQ
Bioorganic chemistry 2023 Oct;139:106652
Bioorganic chemistry 2023 Oct;139:106652
Acid-base homeostasis orchestrated by NHE1 defines the pancreatic stellate cell phenotype in pancreatic cancer.
Pethő Z, Najder K, Beel S, Fels B, Neumann I, Schimmelpfennig S, Sargin S, Wolters M, Grantins K, Wardelmann E, Mitkovski M, Oeckinghaus A, Schwab A
JCI insight 2023 Oct 9;8(19)
JCI insight 2023 Oct 9;8(19)
URI alleviates tyrosine kinase inhibitors-induced ferroptosis by reprogramming lipid metabolism in p53 wild-type liver cancers.
Ding Z, Pan Y, Shang T, Jiang T, Lin Y, Yang C, Pang S, Cui X, Wang Y, Feng XF, Xu M, Pei M, Chen Y, Li X, Ding J, Tan Y, Wang H, Dong L, Wang L
Nature communications 2023 Oct 7;14(1):6269
Nature communications 2023 Oct 7;14(1):6269
Tong Sai granule improves AECOPD via regulation of MAPK-SIRT1-NF-κB pathway and cellular senescence alleviation.
Tao L, Lu X, Fu Z, Tian Y, Liu X, Li J, Zhao P
Journal of ethnopharmacology 2023 Oct 5;314:116622
Journal of ethnopharmacology 2023 Oct 5;314:116622
Effect of Ferulago lutea (Poir.) Grande Essential Oil on Molecular Hallmarks of Skin Aging.
Alves-Silva JM, Moreira P, Cavaleiro C, Pereira C, Cruz MT, Salgueiro L
Plants (Basel, Switzerland) 2023 Oct 31;12(21)
Plants (Basel, Switzerland) 2023 Oct 31;12(21)
Depletion of PIEZO1 expression is accompanied by upregulating p53 signaling in mice with perioperative neurocognitive disorder.
Bai F, Huang L, Long Z, Zhang M, Deng Q, Huang J, Bao X, Hao X, Li H
Functional & integrative genomics 2023 Oct 27;23(4):327
Functional & integrative genomics 2023 Oct 27;23(4):327
Precise genome editing of the Kozak sequence enables bidirectional and quantitative modulation of protein translation to anticipated levels without affecting transcription.
Xie J, Zhuang Z, Gou S, Zhang Q, Wang X, Lan T, Lian M, Li N, Liang Y, Ouyang Z, Ye Y, Wu H, Lai L, Wang K
Nucleic acids research 2023 Oct 13;51(18):10075-10093
Nucleic acids research 2023 Oct 13;51(18):10075-10093
Clearance of Stress-Induced Premature Senescent Cells Alleviates the Formation of Abdominal Aortic Aneurysms.
Xie J, Tang Z, Chen Q, Jia X, Li C, Jin M, Wei G, Zheng H, Li X, Chen Y, Liao W, Liao Y, Bin J, Huang S
Aging and disease 2023 Oct 1;14(5):1778-1798
Aging and disease 2023 Oct 1;14(5):1778-1798
Melatonin alleviates oxidative stress-induced injury to nucleus pulposus-derived mesenchymal stem cells through activating PI3K/Akt pathway.
Huang ZN, Wang ZY, Cheng XF, Huang ZZ, Han YL, Cui YZ, Liu B, Tian W
Journal of orthopaedic translation 2023 Nov;43:66-84
Journal of orthopaedic translation 2023 Nov;43:66-84
USP51 facilitates colorectal cancer stemness and chemoresistance by forming a positive feed-forward loop with HIF1A.
Mu M, Zhang Q, Li J, Zhao C, Li X, Chen Z, Sun X, Yu J
Cell death and differentiation 2023 Nov;30(11):2393-2407
Cell death and differentiation 2023 Nov;30(11):2393-2407
RBM25 regulates hypoxic cardiomyocyte apoptosis through CHOP-associated endoplasmic reticulum stress.
Zhu Z, Pu J, Li Y, Chen J, Ding H, Zhou A, Zhang X
Cell stress & chaperones 2023 Nov;28(6):861-876
Cell stress & chaperones 2023 Nov;28(6):861-876
A Responsive Nanorobot Modulates Intracellular Zinc Homeostasis to Amplify Mitochondria-Targeted Phototherapy.
Zhou X, Zhou A, Tian Z, Chen W, Xu Y, Ning X, Chen K
Small (Weinheim an der Bergstrasse, Germany) 2023 Nov;19(45):e2302952
Small (Weinheim an der Bergstrasse, Germany) 2023 Nov;19(45):e2302952
Hydrogen sulfide inhibits the rupture of fetal membranes throngh anti-aging pathways.
Wang J, Xu J, Chao B, Liu H, Xie L, Qi H, Luo X
Placenta 2023 Nov;143:22-33
Placenta 2023 Nov;143:22-33
Cmpk2 regulates mitochondrial function in glucocorticoid-induced osteoblast senescence and affects glucocorticoid-inhibited osteoblast differentiation.
Cao N, Wang Z, Huang C, Chen B, Zhao P, Xu Y, Tian Y
Archives of gerontology and geriatrics 2023 Nov;114:105080
Archives of gerontology and geriatrics 2023 Nov;114:105080
Bazi Bushen maintains intestinal homeostasis through inhibiting TLR4/NFκB signaling pathway and regulating gut microbiota in SAMP6 mice.
Xu Z, Man SS, Gong BY, Li ZD, Zhou HF, Peng YF, Zhao SW, Hou YL, Wang L, Bian YH
Journal of the science of food and agriculture 2023 Nov;103(14):7273-7283
Journal of the science of food and agriculture 2023 Nov;103(14):7273-7283
Activation of the p53 signaling pathway by piRNA-MW557525 overexpression induces a G0/G1 phase arrest thus inhibiting neuroblastoma growth.
Mi T, Tan X, Wang Z, Zhang Z, Jin L, Wang J, Li M, Wu X, He D
European journal of medical research 2023 Nov 8;28(1):503
European journal of medical research 2023 Nov 8;28(1):503
Extracellular vesicle-derived silk fibroin nanoparticles loaded with MFGE8 accelerate skin ulcer healing by targeting the vascular endothelial cells.
Luo L, Zhang H, Zhang S, Luo C, Kan X, Lv J, Zhao P, Tian Z, Li C
Journal of nanobiotechnology 2023 Nov 29;21(1):455
Journal of nanobiotechnology 2023 Nov 29;21(1):455
IGF2 deficiency promotes liver aging through mitochondrial dysfunction and upregulated CEBPB signaling in D-galactose-induced aging mice.
Zhou X, Tan B, Gui W, Zhou C, Zhao H, Lin X, Li H
Molecular medicine (Cambridge, Mass.) 2023 Nov 28;29(1):161
Molecular medicine (Cambridge, Mass.) 2023 Nov 28;29(1):161
PDK4 rescues high-glucose-induced senescent fibroblasts and promotes diabetic wound healing through enhancing glycolysis and regulating YAP and JNK pathway.
Ma Z, Ding Y, Ding X, Mou H, Mo R, Tan Q
Cell death discovery 2023 Nov 25;9(1):424
Cell death discovery 2023 Nov 25;9(1):424
Role of DCLK1/Hippo pathway in type II alveolar epithelial cells differentiation in acute respiratory distress syndrome.
Chen XY, Kao C, Peng SW, Chang JH, Lee YL, Laiman V, Chung KF, Bhavsar PK, Heriyanto DS, Chuang KJ, Chuang HC
Molecular medicine (Cambridge, Mass.) 2023 Nov 23;29(1):159
Molecular medicine (Cambridge, Mass.) 2023 Nov 23;29(1):159
BSHXF-medicated serum combined with ADSCs regulates the TGF-β1/Smad pathway to repair oxidatively damaged NPCs and its component analysis.
Duan J, Li Z, Liu E, Long H, Chen L, Yang S
Journal of ethnopharmacology 2023 Nov 15;316:116692
Journal of ethnopharmacology 2023 Nov 15;316:116692
Biallelic Dicer1 Mutations in the Gynecologic Tract of Mice Drive Lineage-Specific Development of DICER1 Syndrome-Associated Cancer.
Wang Y, Chen SY, Ta M, Senz J, Tao LV, Thornton S, Tamvada N, Yang W, Moscovitz Y, Li E, Guo J, Shen C, Douglas JM, Ei-Naggar AM, Kommoss FKF, Underhill TM, Singh N, Gilks CB, Morin GB, Huntsman DG
Cancer research 2023 Nov 1;83(21):3517-3528
Cancer research 2023 Nov 1;83(21):3517-3528
Hydrogen sulfide ameliorates endothelial dysfunction in aging arteries by regulating ferroptosis.
Miao Y, Zhang S, Liang Z, Wang Y, Tian D, Jin S, Guo Q, Xue H, Teng X, Xiao L, Wu Y
Nitric oxide : biology and chemistry 2023 Nov 1;140-141:77-90
Nitric oxide : biology and chemistry 2023 Nov 1;140-141:77-90
Naringin against doxorubicin-induced hepatotoxicity in mice through reducing oxidative stress, inflammation, and apoptosis via the up-regulation of SIRT1.
Xi Y, Chi Z, Tao X, Zhai X, Zhao Z, Ren J, Yang S, Dong D
Environmental toxicology 2023 May;38(5):1153-1161
Environmental toxicology 2023 May;38(5):1153-1161
Klotho protects against aged myocardial cells by attenuating ferroptosis.
Xiong X, Wang G, Wang Y, Zhang T, Bao Y, Wang K, Ainiwaer D, Sun Z
Experimental gerontology 2023 May;175:112157
Experimental gerontology 2023 May;175:112157
LncRNA H19 mediates BMP9-induced angiogenesis in mesenchymal stem cells by promoting the p53-Notch1 angiogenic signaling axis.
Du C, Cheng Q, Zhao P, Wang C, Zhu Z, Wu X, Gao S, Chen B, Zou J, Huang W, Liao J
Genes & diseases 2023 May;10(3):1040-1054
Genes & diseases 2023 May;10(3):1040-1054
Anticancer efficacy of hirsuteine against colorectal cancer by opposite modulation of wild-type and mutant p53.
Zhang Y, Guo T, Li S, Ren Z, Gao S, Lu H, Ma X, Liu D, Liu Y, Kong D, Qiu Y
Discover oncology 2023 May 31;14(1):84
Discover oncology 2023 May 31;14(1):84
CX3CR1(hi) macrophages sustain metabolic adaptation by relieving adipose-derived stem cell senescence in visceral adipose tissue.
Zhou Z, Zhang H, Tao Y, Jie H, Zhao J, Zang J, Li H, Wang Y, Wang T, Zhao H, Li Y, Guo C, Zhu F, Mao H, Zhang L, Liu F, Wang Q
Cell reports 2023 May 30;42(5):112424
Cell reports 2023 May 30;42(5):112424
Impairment of rigidity sensing caused by mutant TP53 gain of function in osteosarcoma.
Luo M, Huang M, Yang N, Zhu Y, Huang P, Xu Z, Wang W, Cai L
Bone research 2023 May 29;11(1):28
Bone research 2023 May 29;11(1):28
RSL1D1 knockdown induces ferroptosis and mediates ferrous iron accumulation in senescent cells by inhibiting FTH1 mRNA stability.
Jin Y, Zhao L, Wang S, Zhang X, Quan J, Lin Z, Piao J
Carcinogenesis 2023 May 26;44(2):129-142
Carcinogenesis 2023 May 26;44(2):129-142
Adiponectin Attenuates Splenectomy-Induced Cognitive Deficits by Neuroinflammation and Oxidative Stress via TLR4/MyD88/NF-κb Signaling Pathway in Aged Rats.
Zhang Z, Guo L, Yang F, Peng S, Wang D, Lai X, Su B, Xie H
ACS chemical neuroscience 2023 May 17;14(10):1799-1809
ACS chemical neuroscience 2023 May 17;14(10):1799-1809
LMNB1 deletion in ovarian cancer inhibits the proliferation and metastasis of tumor cells through PI3K/Akt pathway.
Dong J, Ru Y, Zhai L, Gao Y, Guo X, Chen B, Lv X
Experimental cell research 2023 May 15;426(2):113573
Experimental cell research 2023 May 15;426(2):113573
Sulfated fuco-manno-glucuronogalactan alleviates pancreatic beta cell senescence via PI3K/AKT/FoxO1 pathway.
Zhang W, Wu N, Wang H, Mao G, Yan X, Zhang F, Linhardt RJ, Jin W, Zhou J
International journal of biological macromolecules 2023 May 1;236:123846
International journal of biological macromolecules 2023 May 1;236:123846
Alphaherpesvirus upregulates NDRG1 expression to facilitate the nuclear import of viral UL31 and UL34 proteins.
Zhang S, Ming SL, Zeng L, Wang LF, Zhang C, Zhu HS, Yang GY, Zhang GP, Chu BB, Wang J
Journal of medical virology 2023 Mar;95(3):e28591
Journal of medical virology 2023 Mar;95(3):e28591
p52-ZER6: a determinant of tumor cell sensitivity to MDM2-p53 binding inhibitors.
Li WF, Alfason L, Huang C, Tang Y, Qiu L, Miyagishi M, Wu SR, Kasim V
Acta pharmacologica Sinica 2023 Mar;44(3):647-660
Acta pharmacologica Sinica 2023 Mar;44(3):647-660
Adipose tissue-derived Muse cells promote autophagy and oxidative stress tolerance in human epidermal melanocytes.
Wang S, Wang P, Zhang R
Cell and tissue banking 2023 Mar;24(1):253-264
Cell and tissue banking 2023 Mar;24(1):253-264
One Stone, Two Birds: A Peptide-Au(I) Infinite Coordination Supermolecule for the Confederate Physical and Biological Radiosensitization in Cancer Radiation Therapy.
Wang J, Zhao J, Ma F, Gong L, Lu Y, Xiao W, Tang H, Gao C, Chen Y, Ma J, Gao Z, Yan J, Han S
Small (Weinheim an der Bergstrasse, Germany) 2023 Mar;19(11):e2204238
Small (Weinheim an der Bergstrasse, Germany) 2023 Mar;19(11):e2204238
HSPA5 Promotes the Proliferation, Metastasis and Regulates Ferroptosis of Bladder Cancer.
Wang Q, Ke S, Liu Z, Shao H, He M, Guo J
International journal of molecular sciences 2023 Mar 7;24(6)
International journal of molecular sciences 2023 Mar 7;24(6)
Ganoderic Acid A and Its Amide Derivatives as Potential Anti-Cancer Agents by Regulating the p53-MDM2 Pathway: Synthesis and Biological Evaluation.
Jia Y, Li Y, Shang H, Luo Y, Tian Y
Molecules (Basel, Switzerland) 2023 Mar 4;28(5)
Molecules (Basel, Switzerland) 2023 Mar 4;28(5)
Ginsenoside Rg2 Promotes the Proliferation and Stemness Maintenance of Porcine Mesenchymal Stem Cells through Autophagy Induction.
Che L, Zhu C, Huang L, Xu H, Ma X, Luo X, He H, Zhang T, Wang N
Foods (Basel, Switzerland) 2023 Mar 2;12(5)
Foods (Basel, Switzerland) 2023 Mar 2;12(5)
Mitochondrial citrate accumulation triggers senescence of alveolar epithelial cells contributing to pulmonary fibrosis in mice.
Hong JR, Jin L, Zhang CY, Zhong WJ, Yang HH, Wang GM, Ma SC, Guan CX, Li Q, Zhou Y
Heliyon 2023 Jun;9(6):e17361
Heliyon 2023 Jun;9(6):e17361
Peripheral Klotho protects the kidney and brain by regulating M2a/M2c macrophage polarization in d-gal-treated aged mice.
Wang Y, Xiong X, Wang K, Bao Y, Zhang T, Ainiwaer D, Wang G, Li H, Sun Z
Tissue & cell 2023 Jun;82:102049
Tissue & cell 2023 Jun;82:102049
Exercise protects aged mice against coronary endothelial senescence via FUNDC1-dependent mitophagy.
Ma L, Li K, Wei W, Zhou J, Li Z, Zhang T, Wangsun Y, Tian F, Dong Q, Zhang H, Xing W
Redox biology 2023 Jun;62:102693
Redox biology 2023 Jun;62:102693
Senomorphic effect of diphenyleneiodonium through AMPK/MFF/DRP1 mediated mitochondrial fission.
Liao KM, Chen CJ, Luo WJ, Hsu CW, Yu SL, Yang PC, Su KY
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jun;162:114616
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jun;162:114616
Characterizing the specific mechanism of series processed Coptidis Rhizoma by multi-organ metabolomics combined with network pharmacology and molecular docking.
Zhou N, Wang Y, Zhang Z, Feng W, Liu T, Cao Y, Zhang J, Zhang B, Zheng X, Li K
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154804
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154804
EIF4A3-induced Circ_0001187 facilitates AML suppression through promoting ubiquitin-proteasomal degradation of METTL3 and decreasing m6A modification level mediated by miR-499a-5p/RNF113A pathway.
Yang X, Han F, Hu X, Li G, Wu H, Can C, Wei Y, Liu J, Wang R, Jia W, Ji C, Ma D
Biomarker research 2023 Jun 6;11(1):59
Biomarker research 2023 Jun 6;11(1):59
Morusin shows potent antitumor activity for melanoma through apoptosis induction and proliferation inhibition.
Liu W, Ji Y, Wang F, Li C, Shi S, Liu R, Li Q, Guo L, Liu Y, Cui H
BMC cancer 2023 Jun 29;23(1):602
BMC cancer 2023 Jun 29;23(1):602
METTL3-mediated m6A modification of SIRT1 mRNA inhibits progression of endometriosis by cellular senescence enhancing.
Wang X, Wang J, Zhao X, Wu H, Li J, Cheng Y, Guo Q, Cao X, Liang T, Sun L, Zhang G
Journal of translational medicine 2023 Jun 23;21(1):407
Journal of translational medicine 2023 Jun 23;21(1):407
Transgelin promotes ferroptosis to inhibit the malignant progression of esophageal squamous cell carcinoma.
Chen Q, Zhang L, Wan C, Yang B, Kong X, Xu X, Gu Y, Wang C, Liu X, Ding Q, Zhu L, Li Y, Wang B, Zhong W
International journal of oncology 2023 Jul;63(1)
International journal of oncology 2023 Jul;63(1)
EETs alleviate alveolar epithelial cell senescence by inhibiting endoplasmic reticulum stress through the Trim25/Keap1/Nrf2 axis.
Zhang CY, Zhong WJ, Liu YB, Duan JX, Jiang N, Yang HH, Ma SC, Jin L, Hong JR, Zhou Y, Guan CX
Redox biology 2023 Jul;63:102765
Redox biology 2023 Jul;63:102765
Quercetin attenuates angiotensin II-induced proliferation of vascular smooth muscle cells and p53 pathway activation in vitro and in vivo.
Ali F, Wang D, Cheng Y, Wu M, Saleem MZ, Wei L, Xie Y, Yan M, Chu J, Yang Y, Shen A, Peng J
BioFactors (Oxford, England) 2023 Jul-Aug;49(4):956-970
BioFactors (Oxford, England) 2023 Jul-Aug;49(4):956-970
Design, synthesis, and SAR study of novel flavone 1,2,4-oxadiazole derivatives with anti-inflammatory activities for the treatment of Parkinson's disease.
Shen ZB, Meng HW, Meng XS, Lv ZK, Fang MY, Zhang LL, Lv ZL, Li MS, Liu AK, Han JH, Li QS, Duan YJ
European journal of medicinal chemistry 2023 Jul 5;255:115417
European journal of medicinal chemistry 2023 Jul 5;255:115417
Exosomes from tannic acid-stimulated macrophages accelerate wound healing through miR-221-3p mediated fibroblasts migration by targeting CDKN1b.
Song X, Chen Y, Chen X, Zhao X, Zou Y, Li L, Zhou X, Li M, Zhang D, Ye G, Jia R, Yin Z
International journal of biological macromolecules 2023 Jul 31;244:125088
International journal of biological macromolecules 2023 Jul 31;244:125088
Artesunate alleviates 5-fluorouracil-induced intestinal damage by suppressing cellular senescence and enhances its antitumor activity.
Xia J, Dai QL, He S, Jia HJ, Liu XG, Hua H, Zhou M, Wang X
Discover oncology 2023 Jul 27;14(1):139
Discover oncology 2023 Jul 27;14(1):139
Lysine butyrylation of HSP90 regulated by KAT8 and HDAC11 confers chemoresistance.
He Y, Zheng CC, Yang J, Li SJ, Xu TY, Wei X, Chen WY, Jiang ZL, Xu JJ, Zhang GG, Cheng C, Chen KS, Shi XY, Qin DJ, Liu JB, Li B
Cell discovery 2023 Jul 18;9(1):74
Cell discovery 2023 Jul 18;9(1):74
Cold exposure protects against medial arterial calcification development via autophagy.
Li FX, Liu JJ, Xu F, Shan SK, Zheng MH, Lei LM, Lin X, Guo B, Li CC, Wu F, Tang KX, Cao YC, Wu YY, Duan JY, Wu YL, He SY, Chen X, Yuan LQ
Journal of nanobiotechnology 2023 Jul 17;21(1):226
Journal of nanobiotechnology 2023 Jul 17;21(1):226
Long noncoding RNA LINC01594 inhibits the CELF6-mediated splicing of oncogenic CD44 variants to promote colorectal cancer metastasis.
Liu B, Song A, Gui P, Wang J, Pan Y, Li C, Li S, Zhang Y, Jiang T, Xu Y, Pei D, Song J
Cell death & disease 2023 Jul 14;14(7):427
Cell death & disease 2023 Jul 14;14(7):427
Acetylation Targeting Chimera Enables Acetylation of the Tumor Suppressor p53.
Kabir M, Sun N, Hu X, Martin TC, Yi J, Zhong Y, Xiong Y, Kaniskan HÜ, Gu W, Parsons R, Jin J
Journal of the American Chemical Society 2023 Jul 12;145(27):14932-14944
Journal of the American Chemical Society 2023 Jul 12;145(27):14932-14944
HPV-CCDC106 integration promotes cervical cancer progression by facilitating the high expression of CCDC106 after HPV E6 splicing.
Zhi W, Wei Y, Lazare C, Meng Y, Wu P, Gao P, Lin S, Peng T, Chu T, Liu B, Ding W, Cao C, Wu P
Journal of medical virology 2023 Jan;95(1):e28009
Journal of medical virology 2023 Jan;95(1):e28009
RNA-sequencing analysis reveals the potential molecular mechanism of RAD54B in the proliferation of inflamed human dental pulp cells.
Huang P, Wang F, Wang X, Meng X, Qiao W, Meng L
International endodontic journal 2023 Jan;56(1):39-52
International endodontic journal 2023 Jan;56(1):39-52
Verniciflavanol A, a profisetinidin-type-4-arylflavan-3-ol from toxicodendron vernicifluum protects SH-SY5Y cells against H2O2-Induced oxidative stress.
Li M, Zhang Y, Han T, Guan L, Fan D, Wu Q, Liu J, Xu Y, Fan Y
Phytochemistry 2023 Jan;205:113487
Phytochemistry 2023 Jan;205:113487
Dietary selenium excess affected spermatogenesis via DNA damage and telomere-related cell senescence and apoptosis in mice.
Zhang Y, Liu J, Li X, Zhou G, Sang Y, Zhang M, Gao L, Xue J, Zhao M, Yu H, Zhou X
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jan;171:113556
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Jan;171:113556
The CDK inhibitor AT7519 inhibits human glioblastoma cell growth by inducing apoptosis, pyroptosis and cell cycle arrest.
Zhao W, Zhang L, Zhang Y, Jiang Z, Lu H, Xie Y, Han W, Zhao W, He J, Shi Z, Yang H, Chen J, Chen S, Li Z, Mao J, Zhou L, Gao X, Li W, Tan G, Zhang B, Wang Z
Cell death & disease 2023 Jan 9;14(1):11
Cell death & disease 2023 Jan 9;14(1):11
Pold4 is dispensable for mouse development, DNA replication and DNA repair.
Gu X, Dai Q, Du P, Li N, Li J, Zeng S, Peng S, Tang S, Wang L, Zhou Z
Gene 2023 Jan 30;851:147029
Gene 2023 Jan 30;851:147029
Involvement of JNK signaling in Aspergillus fumigatus-induced inflammatory factors release in bronchial epithelial cells.
Cui X, Chen F, Zhao J, Li D, Hu M, Chen X, Zhang Y, Han L
Scientific reports 2023 Jan 23;13(1):1293
Scientific reports 2023 Jan 23;13(1):1293
PKR deficiency delays vascular aging via inhibiting GSDMD-mediated endothelial cell hyperactivation.
Peng Z, Tan X, Xie L, Li Z, Zhou S, Li Y
iScience 2023 Jan 20;26(1):105909
iScience 2023 Jan 20;26(1):105909
Structural basis of bacterial effector protein azurin targeting tumor suppressor p53 and inhibiting its ubiquitination.
Hu J, Jiang W, Zuo J, Shi D, Chen X, Yang X, Zhang W, Ma L, Liu Z, Xing Q
Communications biology 2023 Jan 17;6(1):59
Communications biology 2023 Jan 17;6(1):59
Evaluation of toxicological effects of bisphenol S with an in vitro human bone marrow mesenchymal stem cell: Implications for bone health.
Li M, Li T, Yin J, Xie C, Zhu J
Toxicology 2023 Jan 15;484:153408
Toxicology 2023 Jan 15;484:153408
Molecular mechanism of the miR-7/BCL2L1/P53 signaling axis regulating the progression of hepatocellular carcinoma.
Zhang N, Wang F, Zhu L, Chang R, Mok SRS, Peixoto RD, Tang W, Chen Z
Annals of translational medicine 2023 Jan 15;11(1):12
Annals of translational medicine 2023 Jan 15;11(1):12
Staphylococcal enterotoxin A induces DNA damage in hepatocytes and liver tissues.
Chi K, Zou Y, Liu C, Dong Z, Liu Y, Guo N
Toxicon : official journal of the International Society on Toxinology 2023 Jan 1;221:106980
Toxicon : official journal of the International Society on Toxinology 2023 Jan 1;221:106980
SPY1 inhibits neuronal ferroptosis in amyotrophic lateral sclerosis by reducing lipid peroxidation through regulation of GCH1 and TFR1.
Wang D, Liang W, Huo D, Wang H, Wang Y, Cong C, Zhang C, Yan S, Gao M, Su X, Tan X, Zhang W, Han L, Zhang D, Feng H
Cell death and differentiation 2023 Feb;30(2):369-382
Cell death and differentiation 2023 Feb;30(2):369-382
Navitoclax (ABT-263) Rejuvenates Human Skin by Eliminating Senescent Dermal Fibroblasts in a Mouse/Human Chimeric Model.
Takaya K, Ishii T, Asou T, Kishi K
Rejuvenation research 2023 Feb;26(1):9-20
Rejuvenation research 2023 Feb;26(1):9-20
Hypoxia aggravates the burden of yellowstripe goby (Mugilogobius chulae) under atorvastatin exposure.
Wang Y, Tang T, Ren J, Zhao Y, Hou Y, Nie X
Aquatic toxicology (Amsterdam, Netherlands) 2023 Feb;255:106381
Aquatic toxicology (Amsterdam, Netherlands) 2023 Feb;255:106381
Exploration the role of INHBA in Hu sheep granulosa cells using RNA-Seq.
Bao Y, Li X, El-Samahy MA, Yang H, Wang Z, Yang F, Yao X, Wang F
Theriogenology 2023 Feb;197:198-208
Theriogenology 2023 Feb;197:198-208
Minnelide combined with Angptl3 knockout completely protects mice with adriamycin nephropathy via suppression of TGF-β1-Smad2 and p53 pathways.
Ji B, Liu J, Ma Y, Yin Y, Xu H, Shen Q, Yu J
International immunopharmacology 2023 Feb;115:109656
International immunopharmacology 2023 Feb;115:109656
Revealing active components and action mechanism of Fritillariae Bulbus against non-small cell lung cancer through spectrum-effect relationship and proteomics.
Liu FJ, Chen XY, Yang J, Zhao Z, Wang QL, Li P, Jiang Y, Li HJ
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Feb;110:154635
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Feb;110:154635
Combination of DNA Damage, Autophagy, and ERK Inhibition: Novel Evodiamine-Inspired Multi-Action Pt(IV) Prodrugs with High-Efficiency and Low-Toxicity Antitumor Activity.
Liu XM, Li Z, Xie XR, Wang JQ, Qiao X, Qiao X, Xie CZ, Xu JY
Journal of medicinal chemistry 2023 Feb 9;66(3):1852-1872
Journal of medicinal chemistry 2023 Feb 9;66(3):1852-1872
Dual regulation of Akt and glutathione caused by isoalantolactone effectively triggers human ovarian cancer cell apoptosis.
Xie Z, Xu J, Xiao D, Lei J, Yu J
Acta biochimica et biophysica Sinica 2023 Feb 25;55(1):62-71
Acta biochimica et biophysica Sinica 2023 Feb 25;55(1):62-71
BMAL1/p53 mediating bronchial epithelial cell autophagy contributes to PM2.5-aggravated asthma.
Chen SJ, Huang Y, Yu F, Feng X, Zheng YY, Li Q, Niu Q, Jiang YH, Zhao LQ, Wang M, Cheng PP, Song LJ, Liang LM, He XL, Xiong L, Xiang F, Wang X, Ma WL, Ye H
Cell communication and signaling : CCS 2023 Feb 20;21(1):39
Cell communication and signaling : CCS 2023 Feb 20;21(1):39
Pyrrolyldihydropyrazino[1,2-a]indoletrione Analogue Microtubule Inhibitor Induces Cell-Cycle Arrest and Apoptosis in Colorectal Cancer Cells.
Yang DL, Qin HX, Zhang NN, Zhang YJ, Huang JH, Hu CS, Zhang XX, Li Y, He LJ
Molecules (Basel, Switzerland) 2023 Feb 17;28(4)
Molecules (Basel, Switzerland) 2023 Feb 17;28(4)
N(6)-methyladenosine modification in 18S rRNA promotes tumorigenesis and chemoresistance via HSF4b/HSP90B1/mutant p53 axis.
Chen B, Huang Y, He S, Yu P, Wu L, Peng H
Cell chemical biology 2023 Feb 16;30(2):144-158.e10
Cell chemical biology 2023 Feb 16;30(2):144-158.e10
Porphyromonas gingivalis Outer Membrane Vesicles Promote Apoptosis via msRNA-Regulated DNA Methylation in Periodontitis.
Fan R, Zhou Y, Chen X, Zhong X, He F, Peng W, Li L, Wang X, Xu Y
Microbiology spectrum 2023 Feb 14;11(1):e0328822
Microbiology spectrum 2023 Feb 14;11(1):e0328822
PI3K δ inhibitor PI-3065 induces apoptosis in hepatocellular carcinoma cells by targeting survivin.
Wei Y, Ke W, Lu Z, Ren Y
Chemico-biological interactions 2023 Feb 1;371:110343
Chemico-biological interactions 2023 Feb 1;371:110343
Core-shell SERS nanotags-based western blot.
Liu B, Tang H, Liu Q, Wang W, Li H, Zheng S, Sun F, Zhao X
Talanta 2023 Feb 1;253:123888
Talanta 2023 Feb 1;253:123888
Long noncoding RNA RMRP ameliorates doxorubicin-induced apoptosis by interacting with PFN1 in a P53-Dependent manner.
Li J, Zhou L, Jiang Y, Gao H, Maierhaba T, Gong H
Molecular and cellular probes 2023 Dec;72:101937
Molecular and cellular probes 2023 Dec;72:101937
Ferritinophagy-mediated apoptosis and paraptosis induction involved MAPK and PI3K/AKT pathway in mechanism of an iron chelator.
Wang R, Li J, Fu Y, Li Y, Qi Y, Li C, Gao F, Li C
Biochemical pharmacology 2023 Dec;218:115874
Biochemical pharmacology 2023 Dec;218:115874
Epoxyeicosatrienoic acids alleviate alveolar epithelial cell senescence by inhibiting mitophagy through NOX4/Nrf2 pathway.
Hong JR, Zhang CY, Zhong WJ, Yang HH, Xiong JB, Deng P, Yang NS, Chen H, Jin L, Guan CX, Duan JX, Zhou Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec 31;169:115937
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec 31;169:115937
7-Ketocholesterol accelerates pancreatic β-cell senescence by inhibiting the SIRT1/CDK4-Rb-E2F1 signaling pathway.
Zhu Q, Wang W, Wu N, He S, Lin X, Zhang W, Zhou J
Islets 2023 Dec 31;15(1):2219105
Islets 2023 Dec 31;15(1):2219105
A protocol to investigate the effects of lncRNAs on in vivo protein-protein interactions using proximity ligation assay.
Zhang L, He M, Wang P, Yu J, Li D
STAR protocols 2023 Dec 15;4(4):102757
STAR protocols 2023 Dec 15;4(4):102757
Dapagliflozin impedes endothelial cell senescence by activating the SIRT1 signaling pathway in type 2 diabetes.
Tai S, Zhou Y, Fu L, Ding H, Zhou Y, Yin Z, Yang R, Liu Z, Zhou S
Heliyon 2023 Aug;9(8):e19152
Heliyon 2023 Aug;9(8):e19152
Effect of evernic acid on human breast cancer MCF-7 and MDA-MB-453 cell lines via thioredoxin reductase 1: A molecular approach.
Kalın ŞN, Altay A, Budak H
Journal of applied toxicology : JAT 2023 Aug;43(8):1148-1158
Journal of applied toxicology : JAT 2023 Aug;43(8):1148-1158
Ginkgolide A targets forkhead box O1 to protect against lipopolysaccharide-induced septic cardiomyopathy.
Wang L, Zhao Y, Su Z, Zhao K, Li P, Xu T
Phytotherapy research : PTR 2023 Aug;37(8):3309-3322
Phytotherapy research : PTR 2023 Aug;37(8):3309-3322
N-Acetylserotonin Protects Rat Nucleus Pulposus Cells Against Oxidative Stress Injury by Activating the PI3K/AKT Signaling Pathway.
Yidian W, Jihe K, Xudong G, Daxue Z, Mingqiang L, Xuewen K
World neurosurgery 2023 Aug;176:e109-e124
World neurosurgery 2023 Aug;176:e109-e124
LIM domain-containing protein Ajuba inhibits chemotherapy-induced apoptosis by negatively regulating p53 stability in colorectal cancer cells.
Xu B, Li Q, Zhang J, Chen F
Molecular oncology 2023 Aug;17(8):1678-1691
Molecular oncology 2023 Aug;17(8):1678-1691
CACYBP knockdown inhibits progression of prostate cancer via p53.
Li Q, Liu Z, Ma L, Yin W, Zhang K
Journal of cancer research and clinical oncology 2023 Aug;149(9):5761-5772
Journal of cancer research and clinical oncology 2023 Aug;149(9):5761-5772
HPV18 E6 inhibits α-ketoglutarate-induced pyroptosis of esophageal squamous cell carcinoma cells via the P53/MDH1/ROS/GSDMC pathway.
Tang D, Zheng Y, Wang G, Sheng C, Liu Z, Wang B, Zong Q, Zhang Y, Hou X, Yao M, Zhou Z
FEBS open bio 2023 Aug;13(8):1522-1535
FEBS open bio 2023 Aug;13(8):1522-1535
MicroRNA‑30a‑5p regulates cypermethrin-induced apoptosis of Sertoli cells by targeting KLF9 in vitro.
Wang Q, Xie JF, Yao TT, Wang XX, Guo QW, Wang LS, Yu Y, Xu LC
Reproductive toxicology (Elmsford, N.Y.) 2023 Aug;119:108414
Reproductive toxicology (Elmsford, N.Y.) 2023 Aug;119:108414
A New Type of Endometrial Cancer Models in Mice Revealing the Functional Roles of Genetic Drivers and Exploring their Susceptibilities.
Chen J, Dai S, Zhao L, Peng Y, Sun C, Peng H, Zhong Q, Quan Y, Li Y, Chen X, Pan X, Zhong A, Wang M, Zhang M, Yang S, Lu Y, Lian Z, Liu Y, Zhou S, Li Z, Na F, Chen C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Aug;10(24):e2300383
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Aug;10(24):e2300383
The cellular uptake of Cordyceps sinensis exopolysaccharide‑selenium nanoparticles and their induced apoptosis of HepG2 cells via mitochondria- and death receptor-mediated pathways.
Zhang X, Xiao Y, Huang Q
International journal of biological macromolecules 2023 Aug 30;247:125747
International journal of biological macromolecules 2023 Aug 30;247:125747
A p53/LINC00324 positive feedback loop suppresses tumor growth by counteracting SET-mediated transcriptional repression.
Zhang L, Zhang J, Xuan X, Wu D, Yu J, Wang P, Yang X, Zhang J, Gan W, He M, Liu XM, Zhou J, Wang D, Gu W, Li D
Cell reports 2023 Aug 29;42(8):112833
Cell reports 2023 Aug 29;42(8):112833
Quercetin ameliorates oxidative stress-induced senescence in rat nucleus pulposus-derived mesenchymal stem cells via the miR-34a-5p/SIRT1 axis.
Zhao WJ, Liu X, Hu M, Zhang Y, Shi PZ, Wang JW, Lu XH, Cheng XF, Tao YP, Feng XM, Wang YX, Zhang L
World journal of stem cells 2023 Aug 26;15(8):842-865
World journal of stem cells 2023 Aug 26;15(8):842-865
Network pharmacology prediction and experimental verification of Rhubarb-Peach Kernel promoting apoptosis in endometriosis.
Liao Z, Lei Y, Peng L, Fu X, Wang W, Yang D
BMC complementary medicine and therapies 2023 Aug 19;23(1):291
BMC complementary medicine and therapies 2023 Aug 19;23(1):291
Exploring the regulatory mechanism of tRNA-derived fragments 36 in acute pancreatitis based on small RNA sequencing and experiments.
Fan XR, Huang Y, Su Y, Chen SJ, Zhang YL, Huang WK, Wang H
World journal of gastroenterology 2023 Aug 14;29(30):4642-4656
World journal of gastroenterology 2023 Aug 14;29(30):4642-4656
The Active Fraction of Polyrhachis vicina Roger (AFPR) activates ERK to cause necroptosis in colorectal cancer.
Li DM, Zhu FC, Wei J, Xie JX, He JH, Wei DM, Li Y, Lai KD, Liu LM, Su QB, Wei GN, Wang B, Liu YC
Journal of ethnopharmacology 2023 Aug 10;312:116454
Journal of ethnopharmacology 2023 Aug 10;312:116454
p53 inhibits the Urea cycle and represses polyamine biosynthesis in glioma cell lines.
Zhao Y, Chen Y, Wei L, Ran J, Wang K, Zhu S, Liu Q
Metabolic brain disease 2023 Apr;38(4):1143-1153
Metabolic brain disease 2023 Apr;38(4):1143-1153
Acceleration of melanocyte senescence by the proinflammatory cytokines IFNγ and TNFα impairs the repigmentation response of vitiligo patients to narrowband ultraviolet B (NBUVB) phototherapy.
Dong BQ, Liao ZK, Le Y, Jiang S, Luo LF, Miao F, Le Poole IC, Lei TC
Mechanisms of ageing and development 2023 Apr;211:111779
Mechanisms of ageing and development 2023 Apr;211:111779
Cardamonin alleviates chondrocytes inflammation and cartilage degradation of osteoarthritis by inhibiting ferroptosis via p53 pathway.
Gong Z, Wang Y, Li L, Li X, Qiu B, Hu Y
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Apr;174:113644
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Apr;174:113644
Circular RNA circ0104103 inhibits colorectal cancer progression through interactions with HuR and miR-373-5p.
Tan P, Sun H, Xu M, Liu X, Qin J, Nie J, Qin X, Wang S, Pan Y
Cancer science 2023 Apr;114(4):1396-1409
Cancer science 2023 Apr;114(4):1396-1409
p53 protects against alcoholic fatty liver disease via ALDH2 inhibition.
Yao P, Zhang Z, Liu H, Jiang P, Li W, Du W
The EMBO journal 2023 Apr 17;42(8):e112304
The EMBO journal 2023 Apr 17;42(8):e112304
Chito-oligosaccharides and macrophages have synergistic effects on improving ovarian stem cells function by regulating inflammatory factors.
Zheng K, Hong W, Ye H, Zhou Z, Ling S, Li Y, Dai Y, Zhong Z, Yang Z, Zheng Y
Journal of ovarian research 2023 Apr 14;16(1):76
Journal of ovarian research 2023 Apr 14;16(1):76
AKR1B1 Represses Glioma Cell Proliferation through p38 MAPK-Mediated Bcl-2/BAX/Caspase-3 Apoptotic Signaling Pathways.
Huang YK, Chang KC, Li CY, Lieu AS, Lin CL
Current issues in molecular biology 2023 Apr 13;45(4):3391-3405
Current issues in molecular biology 2023 Apr 13;45(4):3391-3405
Upregulation of TMEM40 is associated with the malignant behavior and promotes tumor progression in cervical cancer.
Zhang ZF, Liu F, Zhang HR, Liu B, Zheng SQ, Ye WQ, Ding JN, Zhou ZJ, Luo HX, Wu F, Guo XM, Zhou JY, Guo YH
Discover oncology 2023 Apr 13;14(1):43
Discover oncology 2023 Apr 13;14(1):43
Excessive serine from the bone marrow microenvironment impairs megakaryopoiesis and thrombopoiesis in Multiple Myeloma.
Kuang C, Xia M, An G, Liu C, Hu C, Zhang J, Liu Z, Meng B, Su P, Xia J, Guo J, Zhu Y, Liu X, Wu X, Shen Y, Feng X, He Y, Li J, Qiu L, Zhou J, Zhou W
Nature communications 2023 Apr 13;14(1):2093
Nature communications 2023 Apr 13;14(1):2093
MiR-122-5p regulates the mevalonate pathway by targeting p53 in non-small cell lung cancer.
Zheng YK, Zhou ZS, Wang GZ, Tu JY, Cheng HB, Ma SZ, Ke C, Wang Y, Jian QP, Shu YH, Wu XW
Cell death & disease 2023 Apr 1;14(4):234
Cell death & disease 2023 Apr 1;14(4):234
Hydrogen Sulfide Inhibits Ferroptosis in Cardiomyocytes to Protect Cardiac Function in Aging Rats.
Liang Z, Miao Y, Teng X, Xiao L, Guo Q, Xue H, Tian D, Jin S, Wu Y
Frontiers in molecular biosciences 2022;9:947778
Frontiers in molecular biosciences 2022;9:947778
6-Shogaol Inhibits Oxidative Stress-Induced Rat Vascular Smooth Muscle Cell Apoptosis by Regulating OXR1-p53 Axis.
Liu J, Li B, Li W, Pan T, Diao Y, Wang F
Frontiers in molecular biosciences 2022;9:808162
Frontiers in molecular biosciences 2022;9:808162
Hydrogen sulfide against preeclampsia exposure-induced oxidative mitochondrial damage in HTR-8/SVneo cells.
Wang X, Yu S, Jian Y, Pan H, Guo J, Wu J, Guo W
Frontiers in cardiovascular medicine 2022;9:1023982
Frontiers in cardiovascular medicine 2022;9:1023982
Proanthocyanidin oligomers extract from hawthorn mediates cell cycle arrest, apoptosis, and lysosome vacuolation on HCT116 cells.
Sun YS, Wang ZW, Gao Z, Zhao W, Thakur K, Zhong Q, Wei ZJ
Current research in food science 2022;5:904-917
Current research in food science 2022;5:904-917
Bovine milk exosomes affected proliferation of macrophages under hypoxia.
Matic S, Dia VP
Current research in food science 2022;5:2108-2113
Current research in food science 2022;5:2108-2113
Jatrorrhizine reduces myocardial infarction-induced apoptosis and fibrosis through inhibiting p53 and TGF-β1/Smad2/3 pathways in mice.
Hao M, Jiao K
Acta cirurgica brasileira 2022;37(7):e370705
Acta cirurgica brasileira 2022;37(7):e370705
Small Nucleolar RNA and C/D Box 15B Regulate the TRIM25/P53 Complex to Promote the Development of Endometrial Cancer.
Wen JT, Chen X, Liu X, Xie BM, Chen JW, Qin HL, Zhao Y
Journal of oncology 2022;2022:7762708
Journal of oncology 2022;2022:7762708
Pygo1 Regulates the Behavior of Human Non-Small-Cell Lung Cancer via the Wnt/β-Catenin Pathway.
Wen Y, Li Y, Yang B, Guo X, Lin L, Liang J, Zhang K, Li X, Jiang Z, Wang Y, Li Y, Wu X, Fan X, Li F, Yuan W
Disease markers 2022;2022:6993994
Disease markers 2022;2022:6993994
Overcoming Basal Autophagy, Kangai Injection Enhances Cisplatin Cytotoxicity by Regulating FOXO3a-Dependent Autophagic Cell Death and Apoptosis in Human Lung Adenocarcinoma A549/DDP Cells.
Zhou H, Pan P, Zhao Q, Liu W, Sun Y, Wang J, Liu C, Wang C
BioMed research international 2022;2022:6022981
BioMed research international 2022;2022:6022981
Using Network Pharmacology and Animal Experiment to Investigate the Therapeutic Mechanisms of Polydatin against Vincristine-Induced Neuropathic Pain.
Xi P, Mao R, Wu S, Liu L, Cai C, Lu L, Zhang C, Li Y
Mediators of inflammation 2022;2022:6010952
Mediators of inflammation 2022;2022:6010952
Cigarette Smoke Exposure Increases Glucose-6-phosphate Dehydrogenase, Autophagy, Fibrosis, and Senescence in Kidney Cells In Vitro and In Vivo.
Liu WC, Chuang HC, Chou CL, Lee YH, Chiu YJ, Wang YL, Chiu HW
Oxidative medicine and cellular longevity 2022;2022:5696686
Oxidative medicine and cellular longevity 2022;2022:5696686
Schwann Cells Accelerate Osteogenesis via the Mif/CD74/FOXO1 Signaling Pathway In Vitro.
Li JQ, Jiang HJ, Su XY, Feng L, Zhan NZ, Li SS, Chen ZJ, Chang BH, Cheng PZ, Yang L, Pei GX
Stem cells international 2022;2022:4363632
Stem cells international 2022;2022:4363632
Rg1 Protects Hematopoietic Stem Cells from LiCl-Induced Oxidative Stress via Wnt Signaling Pathway.
Wang Z, Xia J, Li J, Chen L, Chen X, Zhang Y, Wang L, Wang Y
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2875583
Evidence-based complementary and alternative medicine : eCAM 2022;2022:2875583
Tanshinone IIA Accomplished Protection against Radiation-Induced Cardiomyocyte Injury by Regulating the p38/p53 Pathway.
Wang G, Ma L, Wang B, Gao F, Li J, Cai H, Wang J, Zhang T, Guo H, Xie P, Li Y
Mediators of inflammation 2022;2022:1478181
Mediators of inflammation 2022;2022:1478181
1,25(OH)(2)D(3) Mitigates Oxidative Stress-Induced Damage to Nucleus Pulposus-Derived Mesenchymal Stem Cells through PI3K/Akt Pathway.
Wang JW, Zhu L, Shi PZ, Wang PC, Dai Y, Wang YX, Lu XH, Cheng XF, Feng XM, Zhang L
Oxidative medicine and cellular longevity 2022;2022:1427110
Oxidative medicine and cellular longevity 2022;2022:1427110
Disturbance of Fatty Acid Metabolism Promoted Vascular Endothelial Cell Senescence via Acetyl-CoA-Induced Protein Acetylation Modification.
Lin T, Yang WQ, Luo WW, Zhang LL, Mai YQ, Li ZQ, Liu ST, Jiang LJ, Liu PQ, Li ZM
Oxidative medicine and cellular longevity 2022;2022:1198607
Oxidative medicine and cellular longevity 2022;2022:1198607
Mutant p53 achieved Gain-of-Function by promoting tumor growth and immune escape through PHLPP2/AKT/PD-L1 pathway.
Liu N, Jiang X, Guo L, Zhang C, Jiang M, Sun Z, Zhang Y, Mi W, Li J, Fu Y, Wang F, Zhang L, Zhang Y
International journal of biological sciences 2022;18(6):2419-2438
International journal of biological sciences 2022;18(6):2419-2438
Flap endonuclease 1 Facilitated Hepatocellular Carcinoma Progression by Enhancing USP7/MDM2-mediated P53 Inactivation.
Bian S, Ni W, Zhu M, Zhang X, Qiang Y, Zhang J, Ni Z, Shen Y, Qiu S, Song Q, Xiao M, Zheng W
International journal of biological sciences 2022;18(3):1022-1038
International journal of biological sciences 2022;18(3):1022-1038
DNA Polymerase Gamma Recovers Mitochondrial Function and Inhibits Vascular Calcification by Interacted with p53.
Wang P, Wu B, You S, Lu S, Xiong S, Zou Y, Jia P, Guo X, Zhang Y, Cao L, Sun Y, Zhang N
International journal of biological sciences 2022;18(1):409-425
International journal of biological sciences 2022;18(1):409-425
Rab31 promotes the invasion and metastasis of cervical cancer cells by inhibiting MAPK6 degradation.
Huang Y, Liu R, Han X, Hou X, Tian Y, Zhang W
International journal of biological sciences 2022;18(1):112-123
International journal of biological sciences 2022;18(1):112-123
TEAD1 Silencing Regulates Cell Proliferation and Resistance to 5-Fluorouracil in Cutaneous Squamous Cell Carcinoma.
Wang Z, Liu M, Lei H, Xiao S, Zheng Y
Clinical, cosmetic and investigational dermatology 2022;15:2685-2692
Clinical, cosmetic and investigational dermatology 2022;15:2685-2692
LncRNA LINC00460 facilitates the proliferation and metastasis of renal cell carcinoma via PI3K/AKT signaling pathway.
Zhou FJ, Meng S, Wu XF, Hou PF, Li ML, Chu SF, Bai J, Zheng JN
Journal of Cancer 2022;13(9):2844-2854
Journal of Cancer 2022;13(9):2844-2854
Exploring the pharmacological mechanisms of icaritin against nasopharyngeal carcinoma via network pharmacology and experimental validation.
Liu M, Hu T, Gou W, Chang H, Li Y, Li Y, Zuo D, Hou W, Jiao S
Frontiers in pharmacology 2022;13:993022
Frontiers in pharmacology 2022;13:993022
QishenYiqi dripping pill protects against myocardial ischemia/reperfusion injury via suppressing excessive autophagy and NLRP3 inflammasome based on network pharmacology and experimental pharmacology.
Li M, Wang Y, Qi Z, Yuan Z, Lv S, Zheng Y, Yan Z, Wang M, Fu H, Fan X, Ji N, Liu M, Fang Z
Frontiers in pharmacology 2022;13:981206
Frontiers in pharmacology 2022;13:981206
Antisense Oligonucleotide-Based Therapy on miR-181a-5p Alleviates Cartilage Degradation of Temporomandibular Joint Osteoarthritis via Promoting SIRT1.
Qi H, Zhao Z, Xu L, Zhang Y, Li Y, Xiao L, Li Y, Zhao Z, Fang J
Frontiers in pharmacology 2022;13:898334
Frontiers in pharmacology 2022;13:898334
Phyllanthus Niruri L. Exerts Protective Effects Against the Calcium Oxalate-Induced Renal Injury via Ellgic Acid.
Li MT, Liu LL, Zhou Q, Huang LX, Shi YX, Hou JB, Lu HT, Yu B, Chen W, Guo ZY
Frontiers in pharmacology 2022;13:891788
Frontiers in pharmacology 2022;13:891788
Oridonin Delays Aging Through the AKT Signaling Pathway.
An Y, Zhu J, Wang X, Sun X, Luo C, Zhang Y, Ye Y, Li X, Abulizi A, Huang Z, Zhang H, Yang B, Xie Z
Frontiers in pharmacology 2022;13:888247
Frontiers in pharmacology 2022;13:888247
Gallic acid suppresses the progression of triple-negative breast cancer HCC1806 cells via modulating PI3K/AKT/EGFR and MAPK signaling pathways.
Lin S, Qin HZ, Li ZY, Zhu H, Long L, Xu LB
Frontiers in pharmacology 2022;13:1049117
Frontiers in pharmacology 2022;13:1049117
HPV16 E6-Activated OCT4 Promotes Cervical Cancer Progression by Suppressing p53 Expression via Co-Repressor NCOR1.
Shu S, Li Z, Liu L, Ying X, Zhang Y, Wang T, Zhou X, Jiang P, Lv W
Frontiers in oncology 2022;12:900856
Frontiers in oncology 2022;12:900856
Molecular Classification in Patients With Endometrial Cancer After Fertility-Preserving Treatment: Application of ProMisE Classifier and Combination of Prognostic Evidence.
Ran X, Hu T, Li Z
Frontiers in oncology 2022;12:810631
Frontiers in oncology 2022;12:810631
Loss of CMTM6 promotes DNA damage-induced cellular senescence and antitumor immunity.
Wang H, Fan Y, Chen W, Lv Z, Wu S, Xuan Y, Wang C, Lu Y, Guo T, Shen D, Zhang F, Huang Q, Gao Y, Li H, Ma X, Wang B, Huang Y, Zhang X
Oncoimmunology 2022;11(1):2011673
Oncoimmunology 2022;11(1):2011673
Inflammation and fibrosis in the coal dust-exposed lung described by confocal Raman spectroscopy.
Wang W, Mu M, Zou Y, Li B, Cao H, Hu D, Tao X
PeerJ 2022;10:e13632
PeerJ 2022;10:e13632
Characterization of transcriptional landscape in bone marrow-derived mesenchymal stromal cells treated with aspirin by RNA-seq.
Liu X, Zhan Y, Xu W, Liu L, Liu X, Da J, Zhang K, Zhang X, Wang J, Liu Z, Jin H, Zhang B, Li Y
PeerJ 2022;10:e12819
PeerJ 2022;10:e12819
PLK1 Mitigates Intervertebral Disc Degeneration by Delaying Senescence of Nucleus Pulposus Cells.
Zhang Z, Huang Y, Xu N, Wang J, Yao T, Xu Y, Qiao D, Gao J, Shen S, Ma J
Frontiers in cell and developmental biology 2022;10:819262
Frontiers in cell and developmental biology 2022;10:819262
Harpagoside Protects Against Doxorubicin-Induced Cardiotoxicity via P53-Parkin-Mediated Mitophagy.
Li W, Wang X, Liu T, Zhang Q, Cao J, Jiang Y, Sun Q, Li C, Wang W, Wang Y
Frontiers in cell and developmental biology 2022;10:813370
Frontiers in cell and developmental biology 2022;10:813370
TP53 loss-of-function causes vulnerability to autophagy inhibition in aggressive prostate cancer.
Zhang Y, Song XL, Yu B, Foong LC, Shu Y, Mai CW, Hu J, Dong B, Xue W, Chua CW
International journal of urology : official journal of the Japanese Urological Association 2022 Sep;29(9):1085-1094
International journal of urology : official journal of the Japanese Urological Association 2022 Sep;29(9):1085-1094
UFL1 alleviates ER stress and apoptosis stimulated by LPS via blocking the ferroptosis pathway in human granulosa-like cells.
Li J, Tang X, Tu X, Jin Z, Dong H, Yang Q, Yao T, Pan Z
Cell stress & chaperones 2022 Sep;27(5):485-497
Cell stress & chaperones 2022 Sep;27(5):485-497
Transmembrane protein 121 as a novel inhibitor of cervical cancer metastasis.
Yang B, Cai Y, Zhu P, Jiang Z, Ao J, Zhang Q, Yuan W, Peng Z, Chen J, Wen Y, Chen Y, Wang Y, Shi Y, Zhu X, Ye X, Li F, Zhuang J, Wu X, Li Y, Fan X
Experimental and therapeutic medicine 2022 Sep;24(3):572
Experimental and therapeutic medicine 2022 Sep;24(3):572
Chronic restraint stress promotes gastric epithelial malignant transformation by activating the Akt/p53 signaling pathway via ADRB2.
Zong C, Yang M, Guo X, Ji W
Oncology letters 2022 Sep;24(3):300
Oncology letters 2022 Sep;24(3):300
Elevation of effective p53 expression sensitizes wild-type p53 breast cancer cells to CDK7 inhibitor THZ1.
Wang Y, Zhang Z, Mi X, Li M, Huang D, Song T, Qi X, Yang M
Cell communication and signaling : CCS 2022 Sep 5;20(1):96
Cell communication and signaling : CCS 2022 Sep 5;20(1):96
5-Methoxyflavone-induced AMPKα activation inhibits NF-κB and P38 MAPK signaling to attenuate influenza A virus-mediated inflammation and lung injury in vitro and in vivo.
Yang S, Wang L, Pan X, Liang Y, Zhang Y, Li J, Zhou B
Cellular & molecular biology letters 2022 Sep 30;27(1):82
Cellular & molecular biology letters 2022 Sep 30;27(1):82
HOXA5 inhibits the proliferation of extrahepatic cholangiocarcinoma cells by enhancing MXD1 expression and activating the p53 pathway.
Xiong F, Liu W, Wang X, Wu G, Wang Q, Guo T, Huang W, Wang B, Chen Y
Cell death & disease 2022 Sep 27;13(9):829
Cell death & disease 2022 Sep 27;13(9):829
The therapeutic effect of KSP inhibitors in preclinical models of cholangiocarcinoma.
Shi Y, Cui X, Jiang T, Pan Y, Lin Y, Feng X, Ding Z, Yang C, Tan Y, Wang H, Dong L
Cell death & disease 2022 Sep 19;13(9):799
Cell death & disease 2022 Sep 19;13(9):799
Neuropeptide-Functionalized Gold Nanorod Enhanced Cellular Uptake and Improved In Vitro Photothermal Killing in LRP1-Positive Glioma Cells.
Sivasoorian SS, Urade R, Chiu CC, Wang LF
Pharmaceutics 2022 Sep 13;14(9)
Pharmaceutics 2022 Sep 13;14(9)
Senescent Phenotype of Astrocytes Leads to Activation of BV2 Microglia and N2a Neuronal Cells Death.
Zhang W, Yang X, Liu J, Pan Y, Zhang M, Chen L
Molecules (Basel, Switzerland) 2022 Sep 12;27(18)
Molecules (Basel, Switzerland) 2022 Sep 12;27(18)
P53 regulates mitochondrial biogenesis via transcriptionally induction of mitochondrial ribosomal protein L12.
Han Y, Liu Y, Zhen J, Hou S, Zhang B, Cui Z, Wan Q, Feng H
Experimental cell research 2022 Sep 1;418(1):113249
Experimental cell research 2022 Sep 1;418(1):113249
Functional Phosphoproteomics in Cancer Chemoresistance Using CRISPR-Mediated Base Editors.
Li J, Lin J, Huang S, Li M, Yu W, Zhao Y, Guo J, Zhang P, Huang X, Qiao Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Oct;9(30):e2200717
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Oct;9(30):e2200717
Metabolism-Based Molecular Subtyping Endows Effective Ketogenic Therapy in p53-Mutant Colon Cancer.
Tang M, Xu H, Huang H, Kuang H, Wang C, Li Q, Zhang X, Ge Y, Song M, Zhang X, Wang Z, Ma C, Kang J, Zhang W, Wang Y, Zhang B, Zhang X, Chen Y, Cong M, Melino G, Wang X, Zhou F, Sun Q, Shi H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Oct;9(29):e2201992
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Oct;9(29):e2201992
p53 gene delivery via a recombinant Salmonella enterica Typhimurium leads to human bladder carcinoma cell death in vitro.
Pérez Jorge G, Módolo DG, Jaimes-Florez YP, Fávaro WJ, de Jesus MB, Brocchi M
Letters in applied microbiology 2022 Oct;75(4):1010-1020
Letters in applied microbiology 2022 Oct;75(4):1010-1020
In vitro and in vivo effects of hyperglycemia and diabetes mellitus on nucleus pulposus cell senescence.
Jiang Z, Jiang C, Jin L, Chen Z, Feng Z, Jiang X, Cao Y
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2022 Oct;40(10):2350-2361
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2022 Oct;40(10):2350-2361
Transcription factor YY1 contributes to human melanoma cell growth through modulating the p53 signalling pathway.
Zhou S, Li P, Qin L, Huang S, Dang N
Experimental dermatology 2022 Oct;31(10):1563-1578
Experimental dermatology 2022 Oct;31(10):1563-1578
Protective Effect of Manganese on Apoptosis and Mitochondrial Function of Heat-Stressed Primary Chick Embryonic Myocardial Cells.
Wang R, Shi Z, Li J, Tang D, Qin S, Guo Y
Biological trace element research 2022 Oct;200(10):4419-4429
Biological trace element research 2022 Oct;200(10):4419-4429
The exon 12-containing LHX6 isoforms promote cervical cancer cell proliferation by regulating the MAPK signaling pathway.
Wang L, Zhou Y, Cao C, Lin S, Zhi W, Zhang D, Li J, Wei R, Jiang G, Xu H, Wang X, Xi L, Wu P
Cancer medicine 2022 Oct;11(19):3657-3673
Cancer medicine 2022 Oct;11(19):3657-3673
NOP53 undergoes liquid-liquid phase separation and promotes tumor radio-resistance.
Shi J, Chen SY, Shen XT, Yin XK, Zhao WW, Bai SM, Feng WX, Feng LL, Qin C, Zheng J, Wang YL, Fan XJ
Cell death discovery 2022 Oct 31;8(1):436
Cell death discovery 2022 Oct 31;8(1):436
SF3B4 Depletion Retards the Growth of A549 Non-Small Cell Lung Cancer Cells via UBE4B-Mediated Regulation of p53/p21 and p27 Expression.
Kim H, Lee J, Jung SY, Yun HH, Ko JH, Lee JH
Molecules and cells 2022 Oct 31;45(10):718-728
Molecules and cells 2022 Oct 31;45(10):718-728
Relationship between Neuroglial Apoptosis and Neuroinflammation in the Epileptic Focus of the Brain and in the Blood of Patients with Drug-Resistant Epilepsy.
Sokolova TV, Zabrodskaya YM, Litovchenko AV, Paramonova NM, Kasumov VR, Kravtsova SV, Skiteva EN, Sitovskaya DA, Bazhanova ED
International journal of molecular sciences 2022 Oct 19;23(20)
International journal of molecular sciences 2022 Oct 19;23(20)
Sphingosine-1-Phosphate Alleviates Irradiation Induced Salivary Gland Hypofunction through Preserving Endothelial Cells and Resident Macrophages.
Yang T, Zhao Q, Hu M, Pan S, Zhang L, Zhu R, Zhou B, Feng X, Gao Z, Zhu Z, Zhang Y, Hu L, Liu F, Shan Z
Antioxidants (Basel, Switzerland) 2022 Oct 18;11(10)
Antioxidants (Basel, Switzerland) 2022 Oct 18;11(10)
Design, Synthesis and Evaluation of Novel 1,4-Disubstituted Piperazine-2,5-dione Derivatives as Antioxidants against H(2)O(2)-Induced Oxidative Injury via the IL-6/Nrf2 Loop Pathway.
Xiong L, Wu H, Zhong T, Luo F, Li Q, Li M, Fan Y
Antioxidants (Basel, Switzerland) 2022 Oct 12;11(10)
Antioxidants (Basel, Switzerland) 2022 Oct 12;11(10)
Astaxanthin attenuates osteoarthritis progression via inhibiting ferroptosis and regulating mitochondrial function in chondrocytes.
Wang X, Liu Z, Peng P, Gong Z, Huang J, Peng H
Chemico-biological interactions 2022 Oct 1;366:110148
Chemico-biological interactions 2022 Oct 1;366:110148
Tumor suppressor LHPP suppresses cell proliferation and epithelial-mesenchymal transition in hepatocellular carcinoma cell lines.
Ma L, Sun H, Xu X, Chen Y, Zhang L, Li S, Tang L
Journal of physiology and biochemistry 2022 Nov;78(4):807-817
Journal of physiology and biochemistry 2022 Nov;78(4):807-817
Metformin suppresses vascular smooth muscle cell senescence by promoting autophagic flux.
Tai S, Sun J, Zhou Y, Zhu Z, He Y, Chen M, Yang H, Xiao Y, Tu T, Tang L, Li X, Zeng J, Zheng X, Zhou S
Journal of advanced research 2022 Nov;41:205-218
Journal of advanced research 2022 Nov;41:205-218
Matrix stiffness exacerbates the proinflammatory responses of vascular smooth muscle cell through the DDR1-DNMT1 mechanotransduction axis.
Wang J, Xie SA, Li N, Zhang T, Yao W, Zhao H, Pang W, Han L, Liu J, Zhou J
Bioactive materials 2022 Nov;17:406-424
Bioactive materials 2022 Nov;17:406-424
Maizediterpene D from the roots of Zea mays L. alleviates hydrogen peroxide induced oxidative stress and improves cell survival by activation of TrkB/IGF-1R crosstalk pathways.
Fan Y, Wu H, Xiong L, Luo F, Li Q, Wang D, Zhong T
Fitoterapia 2022 Nov;163:105314
Fitoterapia 2022 Nov;163:105314
Andrographolide elevates tumor necrosis factor-related apoptosis-inducing ligand lethality through reactive oxygen species accumulation and gasdermin E cleavage in breast cancer cells.
Wang Y, Huang D, Song T, Qi X, Li M, Zhang H, Liu Y, Yang M
Medical oncology (Northwood, London, England) 2022 Nov 9;40(1):11
Medical oncology (Northwood, London, England) 2022 Nov 9;40(1):11
Derepression of the USP22-FASN axis by p53 loss under oxidative stress drives lipogenesis and tumorigenesis.
Han Z, Liu M, Xie Y, Zeng K, Zhan Z, Chen Y, Wang L, Chen X, Luo Y, Zeng Y, Zhan H, Lin Y, Zhang K, Zhu X, Liu S, Luo X, Zhou A
Cell death discovery 2022 Nov 4;8(1):445
Cell death discovery 2022 Nov 4;8(1):445
Identification of 3-Phenylquinoline Derivative PQ1 as an Antagonist of p53 Transcriptional Activity.
Wu X, Wang L, Li Z
ACS omega 2022 Nov 29;7(47):43180-43189
ACS omega 2022 Nov 29;7(47):43180-43189
Porcine Circovirus 2 Activates the PERK-Reactive Oxygen Species Axis To Induce p53 Phosphorylation with Subsequent Cell Cycle Arrest at S Phase in Favor of Its Replication.
Deng Z, Sun R, Han X, Zhang Y, Zhou Y, Shan Y, Xu J, Li X, He F, Fang W
Journal of virology 2022 Nov 23;96(22):e0127422
Journal of virology 2022 Nov 23;96(22):e0127422
miR-3168 promotes hepatocellular carcinoma progression via downregulating p53.
Lu T, Han T, Zhao M
Carcinogenesis 2022 Nov 23;43(10):956-968
Carcinogenesis 2022 Nov 23;43(10):956-968
Potential mechanisms underlying the promoting effects of 3D collagen scaffold culture on stemness and drug resistance of glioma cells.
Jia W, Zhu H, Zhao M, Zhou Q, Yin W, Liu W, Wang L, Xiao Z, Jiang X, Dai J, Ren C
Biochimica et biophysica acta. Molecular basis of disease 2022 Nov 1;1868(11):166522
Biochimica et biophysica acta. Molecular basis of disease 2022 Nov 1;1868(11):166522
Effects of thymoquinone against angiotensin II‑induced cardiac damage in apolipoprotein E‑deficient mice.
Zhang L, Zhang H, Ma J, Wang Y, Pei Z, Ding H
International journal of molecular medicine 2022 May;49(5)
International journal of molecular medicine 2022 May;49(5)
Urea transporter B downregulates polyamines levels in melanoma B16 cells via p53 activation.
Li J, Sun Y, Yan R, Wu X, Zou H, Meng Y
Biochimica et biophysica acta. Molecular cell research 2022 May;1869(5):119236
Biochimica et biophysica acta. Molecular cell research 2022 May;1869(5):119236
MDM2 E3 ligase activity is essential for p53 regulation and cell cycle integrity.
Chinnam M, Xu C, Lama R, Zhang X, Cedeno CD, Wang Y, Stablewski AB, Goodrich DW, Wang X
PLoS genetics 2022 May;18(5):e1010171
PLoS genetics 2022 May;18(5):e1010171
Rho family GTPase 1 (RND1), a novel regulator of p53, enhances ferroptosis in glioblastoma.
Sun Q, Xu Y, Yuan F, Qi Y, Wang Y, Chen Q, Liu B
Cell & bioscience 2022 May 3;12(1):53
Cell & bioscience 2022 May 3;12(1):53
A novel 3'tRNA-derived fragment tRF-Val promotes proliferation and inhibits apoptosis by targeting EEF1A1 in gastric cancer.
Cui H, Li H, Wu H, Du F, Xie X, Zeng S, Zhang Z, Dong K, Shang L, Jing C, Li L
Cell death & disease 2022 May 18;13(5):471
Cell death & disease 2022 May 18;13(5):471
Genetic Aberrations and Interaction of NEK2 and TP53 Accelerate Aggressiveness of Multiple Myeloma.
Feng X, Guo J, An G, Wu Y, Liu Z, Meng B, He N, Zhao X, Chen S, Zhu Y, Xia J, Li X, Yu Z, Li R, Ren G, Chen J, Wu M, He Y, Qiu L, Zhou J, Zhou W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Mar;9(9):e2104491
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Mar;9(9):e2104491
USP22-mediated deubiquitination of PTEN inhibits pancreatic cancer progression by inducing p21 expression.
Ren D, Sun Y, Li D, Wu H, Jin X
Molecular oncology 2022 Mar;16(5):1200-1217
Molecular oncology 2022 Mar;16(5):1200-1217
Hepatoprotective mechanism of Silybum marianum on nonalcoholic fatty liver disease based on network pharmacology and experimental verification.
Jiang G, Sun C, Wang X, Mei J, Li C, Zhan H, Liao Y, Zhu Y, Mao J
Bioengineered 2022 Mar;13(3):5216-5235
Bioengineered 2022 Mar;13(3):5216-5235
Novel insights into the mechanisms by which lncRNA HOTAIR regulates migration and invasion in HeLa cells.
Zheng P, Wu Y, Chen Y, Chen Z, Zhang T
Cell cycle (Georgetown, Tex.) 2022 Mar-Mar;21(6):602-617
Cell cycle (Georgetown, Tex.) 2022 Mar-Mar;21(6):602-617
Multifunctional photodynamic/photothermal nano-agents for the treatment of oral leukoplakia.
Lin L, Song C, Wei Z, Zou H, Han S, Cao Z, Zhang X, Zhang G, Ran J, Cai Y, Han W
Journal of nanobiotechnology 2022 Mar 4;20(1):106
Journal of nanobiotechnology 2022 Mar 4;20(1):106
p62 Promotes the Mitochondrial Localization of p53 through Its UBA Domain and Participates in Regulating the Sensitivity of Ovarian Cancer Cells to Cisplatin.
Kong Q, Yan X, Cheng M, Jiang X, Xu L, Shen L, Yu H, Sun L
International journal of molecular sciences 2022 Mar 18;23(6)
International journal of molecular sciences 2022 Mar 18;23(6)
USP49-Mediated Histone H2B Deubiquitination Regulates HCT116 Cell Proliferation through MDM2-p53 Axis.
Shi L, Shen X, Shen Y
Molecular and cellular biology 2022 Mar 17;42(3):e0043421
Molecular and cellular biology 2022 Mar 17;42(3):e0043421
Combined Inactivation of CTPS1 and ATR Is Synthetically Lethal to MYC-Overexpressing Cancer Cells.
Sun Z, Zhang Z, Wang QQ, Liu JL
Cancer research 2022 Mar 15;82(6):1013-1024
Cancer research 2022 Mar 15;82(6):1013-1024
Inhibition of STAT3(Y705) phosphorylation by Stattic suppresses proliferation and induces mitochondrial-dependent apoptosis in pancreatic cancer cells.
Guo H, Xiao Y, Yuan Z, Yang X, Chen J, Chen C, Wang M, Xie L, Chen Q, Tong Y, Zhang Q, Bai Y
Cell death discovery 2022 Mar 14;8(1):116
Cell death discovery 2022 Mar 14;8(1):116
SRSF1 governs progenitor-specific alternative splicing to maintain adult epithelial tissue homeostasis and renewal.
Yu T, Cazares O, Tang AD, Kim HY, Wald T, Verma A, Liu Q, Barcellos-Hoff MH, Floor SN, Jung HS, Brooks AN, Klein OD
Developmental cell 2022 Mar 14;57(5):624-637.e4
Developmental cell 2022 Mar 14;57(5):624-637.e4
Exercise suppresses mouse systemic AApoAII amyloidosis through enhancement of the p38 MAPK signaling pathway.
Cui X, Sawashita J, Dai J, Liu C, Igarashi Y, Mori M, Miyahara H, Higuchi K
Disease models & mechanisms 2022 Mar 1;15(3)
Disease models & mechanisms 2022 Mar 1;15(3)
The serum soluble Klotho alleviates cardiac aging and regulates M2a/M2c macrophage polarization via inhibiting TLR4/Myd88/NF-κB pathway.
Wang Y, Wang K, Bao Y, Zhang T, Ainiwaer D, Xiong X, Wang G, Sun Z
Tissue & cell 2022 Jun;76:101812
Tissue & cell 2022 Jun;76:101812
Pyrimethamine inhibits cell growth by inducing cell senescence and boosting CD8(+) T-cell mediated cytotoxicity in colorectal cancer.
Dong H, Hu L, Li W, Shi M, He L, Wang C, Hu Y, Wang H, Wen C, Liu H, Yang X
Molecular biology reports 2022 Jun;49(6):4281-4292
Molecular biology reports 2022 Jun;49(6):4281-4292
p53 m(6)A modulation sensitizes hepatocellular carcinoma to apatinib through apoptosis.
Ke W, Zhang L, Zhao X, Lu Z
Apoptosis : an international journal on programmed cell death 2022 Jun;27(5-6):426-440
Apoptosis : an international journal on programmed cell death 2022 Jun;27(5-6):426-440
The role of ALOX15B in heat stress-induced apoptosis of porcine sertoli cells.
Xue H, Huo Y, Hu Y, Zhang J, Deng C, Zhang J, Wang X
Theriogenology 2022 Jun;185:6-15
Theriogenology 2022 Jun;185:6-15
DEHP induces ferroptosis in testes via p38α-lipid ROS circulation and destroys the BTB integrity.
Yang L, Jiang L, Sun X, Li J, Wang N, Liu X, Yao X, Zhang C, Deng H, Wang S, Yang G
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Jun;164:113046
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 Jun;164:113046
Novel Flavan-3,4-diol vernicidin B from Toxicodendron Vernicifluum (Anacardiaceae) as potent antioxidant via IL-6/Nrf2 cross-talks pathways.
Zhong T, Li M, Wu H, Wang D, Liu J, Xu Y, Fan Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154041
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154041
Stress-induced epinephrine promotes epithelial-to-mesenchymal transition and stemness of CRC through the CEBPB/TRIM2/P53 axis.
Zhou Z, Shu Y, Bao H, Han S, Liu Z, Zhao N, Yuan W, Jian C, Shu X
Journal of translational medicine 2022 Jun 7;20(1):262
Journal of translational medicine 2022 Jun 7;20(1):262
p53-Dependent Mitochondrial Compensation in Heart Failure With Preserved Ejection Fraction.
Chen X, Lin H, Xiong W, Pan J, Huang S, Xu S, He S, Lei M, Chang ACY, Zhang H
Journal of the American Heart Association 2022 Jun 7;11(11):e024582
Journal of the American Heart Association 2022 Jun 7;11(11):e024582
Synthesis and structure-activity relationship study of a potent MHO7 analogue as potential anti-triple negative breast cancer agent.
Liang JJ, Yu WL, Yang L, Qin KM, Yin YP, Li D, Ni YH, Yan JJ, Zhong YX, Deng ZX, Hong K
European journal of medicinal chemistry 2022 Jun 5;236:114313
European journal of medicinal chemistry 2022 Jun 5;236:114313
Interleukin-13 promotes cellular senescence through inducing mitochondrial dysfunction in IgG4-related sialadenitis.
Zhu M, Min S, Mao X, Zhou Y, Zhang Y, Li W, Li L, Wu L, Cong X, Yu G
International journal of oral science 2022 Jun 20;14(1):29
International journal of oral science 2022 Jun 20;14(1):29
Analysis by transcriptomics and metabolomics for the proliferation inhibition and dysfunction through redox imbalance-mediated DNA damage response and ferroptosis in male reproduction of mice and TM4 Sertoli cells exposed to PM(2.5).
Shi F, Zhang Z, Cui H, Wang J, Wang Y, Tang Y, Yang W, Zou P, Ling X, Han F, Liu J, Chen Q, Liu C, Cao J, Ao L
Ecotoxicology and environmental safety 2022 Jun 15;238:113569
Ecotoxicology and environmental safety 2022 Jun 15;238:113569
Inhibition of the lncRNA MIAT prevents podocyte injury and mitotic catastrophe in diabetic nephropathy.
Wang Z, Chang Y, Liu Y, Liu B, Zhen J, Li X, Lin J, Yu Q, Lv Z, Wang R
Molecular therapy. Nucleic acids 2022 Jun 14;28:136-153
Molecular therapy. Nucleic acids 2022 Jun 14;28:136-153
Inhibiting the IRE1α Axis of the Unfolded Protein Response Enhances the Antitumor Effect of AZD1775 in TP53 Mutant Ovarian Cancer.
Xiao R, You L, Zhang L, Guo X, Guo E, Zhao F, Yang B, Li X, Fu Y, Lu F, Wang Z, Liu C, Peng W, Li W, Yang X, Dou Y, Liu J, Wang W, Qin T, Cui Y, Zhang X, Li F, Jin Y, Zeng Q, Wang B, Mills GB, Chen G, Sheng X, Sun C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Jul;9(21):e2105469
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Jul;9(21):e2105469
MG53 protein rejuvenates hUC-MSCs and facilitates their therapeutic effects in AD mice by activating Nrf2 signaling pathway.
Ma S, Zhou X, Wang Y, Li Z, Wang Y, Shi J, Guan F
Redox biology 2022 Jul;53:102325
Redox biology 2022 Jul;53:102325
Low doses of niclosamide and quinacrine combination yields synergistic effect in melanoma via activating autophagy-mediated p53-dependent apoptosis.
Zheng X, Zhang J, Li S, Gao X, Zhang Y, Wang M, Dong L, Sun L, Zhao N, Ma Z, Ding C, Wang Y
Translational oncology 2022 Jul;21:101425
Translational oncology 2022 Jul;21:101425
Effect of alfalfa substituted with ramie on the expression of apoptotic genes in the gastrointestinal tracts of goats.
Liu Q, Fu C, Yang H, Zhou C, Kang J, Chen L, Kong Z, Tan Z, Tang S
Food science & nutrition 2022 Jul;10(7):2400-2407
Food science & nutrition 2022 Jul;10(7):2400-2407
The Role of Ferroptosis in the Damage of Human Proximal Tubule Epithelial Cells Caused by Perfluorooctane Sulfonate.
Wang P, Liu D, Yan S, Liang Y, Cui J, Guo L, Ren S, Chen P
Toxics 2022 Jul 29;10(8)
Toxics 2022 Jul 29;10(8)
COX-2/sEH Dual Inhibitor Alleviates Hepatocyte Senescence in NAFLD Mice by Restoring Autophagy through Sirt1/PI3K/AKT/mTOR.
Zhang CY, Tan XH, Yang HH, Jin L, Hong JR, Zhou Y, Huang XT
International journal of molecular sciences 2022 Jul 27;23(15)
International journal of molecular sciences 2022 Jul 27;23(15)
Targeted demethylation of the SLC5A7 promotor inhibits colorectal cancer progression.
Li Y, Liu B, Yin X, Jiang Z, Fang C, Chen N, Zhang B, Dai L, Yin Y
Clinical epigenetics 2022 Jul 20;14(1):92
Clinical epigenetics 2022 Jul 20;14(1):92
Cancer cells corrupt normal epithelial cells through miR-let-7c-rich small extracellular vesicle-mediated downregulation of p53/PTEN.
Liang W, Chen Y, Liu H, Zhao H, Luo T, Tang H, Zhou X, Jiang E, Shao Z, Liu K, Shang Z
International journal of oral science 2022 Jul 19;14(1):36
International journal of oral science 2022 Jul 19;14(1):36
Diffractaic acid, a novel TrxR1 inhibitor, induces cytotoxicity, apoptosis, and antimigration in human breast cancer cells.
Kalın ŞN, Altay A, Budak H
Chemico-biological interactions 2022 Jul 1;361:109984
Chemico-biological interactions 2022 Jul 1;361:109984
Identification of a novel native peptide derived from 60S ribosomal protein L23a that translationally regulates p53 to reduce myocardial ischemia-reperfusion.
Yin A, Feng M, Zhang L, Cheng Z, Li Y, Qian L
Pharmacological research 2022 Jan;175:105988
Pharmacological research 2022 Jan;175:105988
Integrating network pharmacology deciphers the action mechanism of Zuojin capsule in suppressing colorectal cancer.
Fan JH, Xu MM, Zhou LM, Gui ZW, Huang L, Li XG, Ye XL
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Feb;96:153881
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Feb;96:153881
A new FGF1 variant protects against adriamycin-induced cardiotoxicity via modulating p53 activity.
Xiao M, Tang Y, Wang J (a), Lu G, Niu J, Wang J (b), Li J, Liu Q, Wang Z, Huang Z, Guo Y, Gao T, Zhang X, Yue S, Gu J
Redox biology 2022 Feb;49:102219
Redox biology 2022 Feb;49:102219
m6A demethylation of cytidine deaminase APOBEC3B mRNA orchestrates arsenic-induced mutagenesis.
Gao M, Qi Z, Feng W, Huang H, Xu Z, Dong Z, Xu M, Han J, Kloeber JA, Huang J, Lou Z, Liu S
The Journal of biological chemistry 2022 Feb;298(2):101563
The Journal of biological chemistry 2022 Feb;298(2):101563
Survivin suppression heightens BZML-induced mitotic catastrophe to overcome multidrug resistance by removing therapy-induced senescent A549/Taxol cells.
Bai Z, Zhou Y, Ye X, Li Y, Peng Y, Guan Q, Zhang W, Ma L
Biochimica et biophysica acta. Molecular cell research 2022 Feb;1869(2):119174
Biochimica et biophysica acta. Molecular cell research 2022 Feb;1869(2):119174
Persistent high glucose induced EPB41L4A-AS1 inhibits glucose uptake via GCN5 mediating crotonylation and acetylation of histones and non-histones.
Liao W, Xu N, Zhang H, Liao W, Wang Y, Wang S, Zhang S, Jiang Y, Xie W, Zhang Y
Clinical and translational medicine 2022 Feb;12(2):e699
Clinical and translational medicine 2022 Feb;12(2):e699
Integrative investigation of the TF-miRNA coregulatory network involved in the inhibition of breast cancer cell proliferation by resveratrol.
Zhou Y, Zhang J, Li W, Zhang D, Wang Z, Zhai Y, Yu H, Li Z
FEBS open bio 2022 Feb;12(2):379-393
FEBS open bio 2022 Feb;12(2):379-393
MiR-187 regulates the proliferation, migration and invasion of human trophoblast cells by repressing BCL6-mediated activation of PI3K/AKT signaling.
Chen X, Song QL, Ji R, Wang JY, Li ZH, Guo D, Yin TL, Wang SJ, Yang J
Placenta 2022 Feb;118:20-31
Placenta 2022 Feb;118:20-31
Berberine ameliorates erectile dysfunction in rats with streptozotocin-induced diabetes mellitus through the attenuation of apoptosis by inhibiting the SPHK1/S1P/S1PR2 and MAPK pathways.
Liu K, Sun T, Luan Y, Chen Y, Song J, Ling L, Yuan P, Li R, Cui K, Ruan Y, Lan R, Wang T, Wang S, Liu J, Rao K
Andrology 2022 Feb;10(2):404-418
Andrology 2022 Feb;10(2):404-418
Anticancer effects of myricetin derivatives in non-small cell lung cancer in vitro and in vivo.
Li M, Zha G, Chen R, Chen X, Sun Q, Jiang H
Pharmacology research & perspectives 2022 Feb;10(1):e00905
Pharmacology research & perspectives 2022 Feb;10(1):e00905
Hepatocyte nuclear factor 4 gamma (HNF4G) is correlated with poor prognosis and promotes tumor cell growth by inhibiting caspase-dependent intrinsic apoptosis in colorectal cancer.
Chen L, Shi H, Wang X, Wang T, Wang Y, Wu Z, Zhang W, Chen H, Zhong M, Mao X, Shi X, Li Q
European journal of pharmacology 2022 Feb 5;916:174727
European journal of pharmacology 2022 Feb 5;916:174727
Design and synthesis of marine sesterterpene analogues as novel estrogen receptor α degraders for breast cancer treatment.
Liang JJ, Yu WL, Yang L, Xie BH, Qin KM, Yin YP, Yan JJ, Gong S, Liu TY, Zhou HB, Hong K
European journal of medicinal chemistry 2022 Feb 5;229:114081
European journal of medicinal chemistry 2022 Feb 5;229:114081
Targeting and neutralizing human epididymis protein 4 by novel nanobodies to suppress ovarian cancer cells and attenuate cisplatin resistance.
Yu J, Guo Y, Gu Y, Li F, Song H, Nian R, Fan X, Liu W
International journal of biological macromolecules 2022 Feb 28;199:298-306
International journal of biological macromolecules 2022 Feb 28;199:298-306
Pan-cancer analysis of oncogenic role of Programmed Cell Death 2 Like (PDCD2L) and validation in colorectal cancer.
Gao H, Xu C, Liang J, Ge S, Zhang F, Tuo Y, Shi H, Han A
Cancer cell international 2022 Feb 25;22(1):100
Cancer cell international 2022 Feb 25;22(1):100
The dual role of p62 in ferroptosis of glioblastoma according to p53 status.
Yuan F, Sun Q, Zhang S, Ye L, Xu Y, Deng G, Xu Z, Zhang S, Liu B, Chen Q
Cell & bioscience 2022 Feb 25;12(1):20
Cell & bioscience 2022 Feb 25;12(1):20
Blocking iASPP/Nrf2/M-CSF axis improves anti-cancer effect of chemotherapy-induced senescence by attenuating M2 polarization.
Liu H, Zhao D, Li H, Zhang W, Lin Q, Wang X, Zheng S, Zhang L, Li L, Hu S, Hu Y
Cell death & disease 2022 Feb 21;13(2):166
Cell death & disease 2022 Feb 21;13(2):166
Ginsenoside Rh4 Suppressed Metastasis of Lung Adenocarcinoma via Inhibiting JAK2/STAT3 Signaling.
Zhang Y, Ma P, Duan Z, Liu Y, Mi Y, Fan D
International journal of molecular sciences 2022 Feb 11;23(4)
International journal of molecular sciences 2022 Feb 11;23(4)
Fulminant lung fibrosis in non-resolvable COVID-19 requiring transplantation.
Jyothula SSK, Peters A, Liang Y, Bi W, Shivshankar P, Yau S, Garcha PS, Yuan X, Akkanti B, Collum S, Wareing N, Thandavarayan RA, Poli de Frias F, Rosas IO, Zhao B, Buja LM, Eltzschig HK, Huang HJ, Karmouty-Quintana H
EBioMedicine 2022 Dec;86:104351
EBioMedicine 2022 Dec;86:104351
Resveratrol inhibits the progression of premature senescence partially by regulating v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA) and sirtuin 1 (SIRT1).
He S, Zhou M, Zheng H, Wang Y, Wu S, Gao Y, Chen J
Renal failure 2022 Dec;44(1):171-183
Renal failure 2022 Dec;44(1):171-183
Pseudogene CSPG4P12 affects the biological behavior of non‑small cell lung cancer by Bcl‑2/Bax mitochondrial apoptosis pathway.
Hu W, Wu H, Li A, Zheng X, Zhang W, Tian Q, Zhang X
Experimental and therapeutic medicine 2022 Dec;24(6):734
Experimental and therapeutic medicine 2022 Dec;24(6):734
Polysaccharide ORP-1 isolated from Oudemansiella raphanipes ameliorates age-associated intestinal epithelial barrier dysfunction in Caco-2 cells monolayer.
Pan WJ, Shi LL, Ren YR, Yao CY, Lu YM, Chen Y
Food research international (Ottawa, Ont.) 2022 Dec;162(Pt A):112038
Food research international (Ottawa, Ont.) 2022 Dec;162(Pt A):112038
VLA-4 suppression by senescence signals regulates meningeal immunity and leptomeningeal metastasis.
Li J, Huang D, Lei B, Huang J, Yang L, Nie M, Su S, Zhao Q, Wang Y
eLife 2022 Dec 9;11
eLife 2022 Dec 9;11
The C-terminus of Gain-of-Function Mutant p53 R273H Is Required for Association with PARP1 and Poly-ADP-Ribose.
Lundine D, Annor GK, Chavez V, Maimos S, Syed Z, Jiang S, Ellison V, Bargonetti J
Molecular cancer research : MCR 2022 Dec 2;20(12):1799-1810
Molecular cancer research : MCR 2022 Dec 2;20(12):1799-1810
Inhibition of TIGAR Increases Exogenous p53 and Cisplatin Combination Sensitivity in Lung Cancer Cells by Regulating Glycolytic Flux.
Fu J, Yu S, Zhao X, Zhang C, Shen L, Liu Y, Yu H
International journal of molecular sciences 2022 Dec 16;23(24)
International journal of molecular sciences 2022 Dec 16;23(24)
FUT2 Facilitates Autophagy and Suppresses Apoptosis via p53 and JNK Signaling in Lung Adenocarcinoma Cells.
Zhang Y, Yao E, Liu Y, Zhang Y, Ding M, Liu J, Chen X, Fan S
Cells 2022 Dec 13;11(24)
Cells 2022 Dec 13;11(24)
Inhibition of thioredoxin reductase 1 by vulpinic acid suppresses the proliferation and migration of human breast carcinoma.
Kalın ŞN, Altay A, Budak H
Life sciences 2022 Dec 1;310:121093
Life sciences 2022 Dec 1;310:121093
Chitosan-Gelatin-EGCG Nanoparticle-Meditated LncRNA TMEM44-AS1 Silencing to Activate the P53 Signaling Pathway for the Synergistic Reversal of 5-FU Resistance in Gastric Cancer.
Zhou M, Dong J, Huang J, Ye W, Zheng Z, Huang K, Pan Y, Cen J, Liang Y, Shu G, Ye S, Lu X, Zhang J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Aug;9(22):e2105077
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Aug;9(22):e2105077
PM2.5-Induced Programmed Myocardial Cell Death via mPTP Opening Results in Deteriorated Cardiac Function in HFpEF Mice.
Wu T, Tong M, Chu A, Wu K, Niu X, Zhang Z
Cardiovascular toxicology 2022 Aug;22(8):746-762
Cardiovascular toxicology 2022 Aug;22(8):746-762
LncRNA SNHG11 promotes the malignant transformation of human bronchial epithelial cells induced by beryllium sulfate.
Deng W, Sun Z, Chen S, Li G, Liu X, Huang L, Zhang Z
Toxicology research 2022 Aug;11(4):605-615
Toxicology research 2022 Aug;11(4):605-615
Long noncoding RNA CERS6-AS1 modulates glucose metabolism and tumor progression in hepatocellular carcinoma by promoting the MDM2/p53 signaling pathway.
Xu B, Wei Y, Liu F, Li L, Zhou S, Peng Y, Li B
Cell death discovery 2022 Aug 4;8(1):348
Cell death discovery 2022 Aug 4;8(1):348
p53 Binding Sites in Long Terminal Repeat 5Hs (LTR5Hs) of Human Endogenous Retrovirus K Family (HML-2 Subgroup) Play Important Roles in the Regulation of LTR5Hs Transcriptional Activity.
Liu M, Jia L, Li H, Liu Y, Han J, Wang X, Li T, Li J, Zhang B, Zhai X, Yu C, Li L
Microbiology spectrum 2022 Aug 31;10(4):e0048522
Microbiology spectrum 2022 Aug 31;10(4):e0048522
BCAS3 accelerates glioblastoma tumorigenesis by restraining the P53/GADD45α signaling pathway.
Wang Y, Li Y, Sun Q, Yuan F, Xu Y, Tong S, Li Y, Yi S, Yan T, Chen Q, Liu B
Experimental cell research 2022 Aug 15;417(2):113231
Experimental cell research 2022 Aug 15;417(2):113231
TDP-43 upregulates lipid metabolism modulator ABHD2 to suppress apoptosis in hepatocellular carcinoma.
Liu BW, Wang XY, Cao JL, Chen LL, Wang YL, Zhao BQ, Zhou J, Shen ZF
Communications biology 2022 Aug 13;5(1):816
Communications biology 2022 Aug 13;5(1):816
Knockdown of RRM1 in tumor cells promotes radio-/chemotherapy induced ferroptosis by regulating p53 ubiquitination and p21-GPX4 signaling axis.
Gao Y, Chen B, Wang R, Xu A, Wu L, Lu H, Zhao G
Cell death discovery 2022 Aug 1;8(1):343
Cell death discovery 2022 Aug 1;8(1):343
Downregulation of CPT2 promotes proliferation and inhibits apoptosis through p53 pathway in colorectal cancer.
Liu F, Li X, Yan H, Wu J, Yang Y, He J, Chen J, Jiang Z, Wu F, Jiang Z
Cellular signalling 2022 Apr;92:110267
Cellular signalling 2022 Apr;92:110267
Genetic Catalytic Inactivation of GRK5 Impairs Cardiac Function in Mice Via Dysregulated P53 Levels.
Marzano F, Liccardo D, Elia A, Mucio I, de Lucia C, Lucchese AM, Gao E, Ferrara N, Rapacciuolo A, Paolocci N, Rengo G, Koch WJ, Cannavo A
JACC. Basic to translational science 2022 Apr;7(4):366-380
JACC. Basic to translational science 2022 Apr;7(4):366-380
Silence of MLK3 alleviates lipopolysaccharide-induced lung epithelial cell injury via inhibiting p53-mediated ferroptosis.
Chen X, Qi G, Fang F, Miao Y, Wang L
Journal of molecular histology 2022 Apr;53(2):503-510
Journal of molecular histology 2022 Apr;53(2):503-510
Novel CDK9 inhibitor oroxylin A promotes wild-type P53 stability and prevents hepatocellular carcinoma progression by disrupting both MDM2 and SIRT1 signaling.
Yao JY, Xu S, Sun YN, Xu Y, Guo QL, Wei LB
Acta pharmacologica Sinica 2022 Apr;43(4):1033-1045
Acta pharmacologica Sinica 2022 Apr;43(4):1033-1045
TIM-1 promotes proliferation and metastasis, and inhibits apoptosis, in cervical cancer through the PI3K/AKT/p53 pathway.
Chen L, Qing J, Xiao Y, Huang X, Chi Y, Chen Z
BMC cancer 2022 Apr 7;22(1):370
BMC cancer 2022 Apr 7;22(1):370
Ginsenoside Rk1 regulates glutamine metabolism in hepatocellular carcinoma through inhibition of the ERK/c-Myc pathway.
Lu H, Yin H, Qu L, Ma X, Fu R, Fan D
Food & function 2022 Apr 4;13(7):3793-3811
Food & function 2022 Apr 4;13(7):3793-3811
CYLD deficiency enhances metabolic reprogramming and tumor progression in nasopharyngeal carcinoma via PFKFB3.
Wang L, Lin Y, Zhou X, Chen Y, Li X, Luo W, Zhou Y, Cai L
Cancer letters 2022 Apr 28;532:215586
Cancer letters 2022 Apr 28;532:215586
Activation of Esterase D by FPD5 Inhibits Growth of A549 Lung Cancer Cells via JAB1/p53 Pathway.
Yao W, Yang Y, Chen X, Cui X, Zhou B, Zhao B, Lin Z, Miao J
Genes 2022 Apr 28;13(5)
Genes 2022 Apr 28;13(5)
Mandarin Fish (Siniperca chuatsi) p53 Regulates Glutaminolysis Induced by Virus via the p53/miR145-5p/c-Myc Pathway in Chinese Perch Brain Cells.
Ye C, Liu S, Li N, Zuo S, Niu Y, Lin Q, Liang H, Luo X, Fu X
Microbiology spectrum 2022 Apr 27;10(2):e0272721
Microbiology spectrum 2022 Apr 27;10(2):e0272721
RETREG1-mediated ER-phagy activation induced by glucose deprivation alleviates nucleus pulposus cell damage via ER stress pathway.
Luo R, Liang H, Zhang W, Li G, Zhao K, Hua W, Song Y, Yang C
Acta biochimica et biophysica Sinica 2022 Apr 25;54(4):524-536
Acta biochimica et biophysica Sinica 2022 Apr 25;54(4):524-536
LncRNA LYPLAL1-AS1 rejuvenates human adipose-derived mesenchymal stem cell senescence via transcriptional MIRLET7B inactivation.
Yang Y, Liu S, He C, Lv T, Zeng L, Zhang F, Chen H, Zhao RC
Cell & bioscience 2022 Apr 21;12(1):45
Cell & bioscience 2022 Apr 21;12(1):45
Predict the role of lncRNA in kidney aging based on RNA sequencing.
Li J, Gao F, Wei L, Chen L, Qu N, Zeng L, Luo Y, Huang X, Jiang H
BMC genomics 2022 Apr 2;23(1):254
BMC genomics 2022 Apr 2;23(1):254
The E3 Ligase RNF157 Inhibits Lens Epithelial Cell Apoptosis by Negatively Regulating p53 in Age-Related Cataracts.
Qi T, Jing R, Ma B, Hu C, Wen C, Shao Y, Pei C
Investigative ophthalmology & visual science 2022 Apr 1;63(4):11
Investigative ophthalmology & visual science 2022 Apr 1;63(4):11
CircSCAP interacts with SF3A3 to inhibit the malignance of non-small cell lung cancer by activating p53 signaling.
Chen D, Zhou H, Cai Z, Cai K, Liu J, Wang W, Miao H, Li H, Li R, Li X, Chen Y, Wang HY, Wen Z
Journal of experimental & clinical cancer research : CR 2022 Apr 1;41(1):120
Journal of experimental & clinical cancer research : CR 2022 Apr 1;41(1):120
Chaperone-mediated autophagy plays an important role in regulating retinal progenitor cell homeostasis.
Jin C, Ou Q, Chen J, Wang T, Zhang J, Wang Z, Wang Y, Tian H, Xu JY, Gao F, Wang J, Li J, Lu L, Xu GT
Stem cell research & therapy 2022 Apr 1;13(1):136
Stem cell research & therapy 2022 Apr 1;13(1):136
Utilizing network pharmacology and molecular docking to explore the underlying mechanism of Guizhi Fuling Wan in treating endometriosis.
Wang H, Zhou G, Zhuang M, Wang W, Fu X
PeerJ 2021;9:e11087
PeerJ 2021;9:e11087
Construction of a Novel Ferroptosis-Related Gene Signature of Atherosclerosis.
Huang T, Wang K, Li Y, Ye Y, Chen Y, Wang J, Yao C
Frontiers in cell and developmental biology 2021;9:800833
Frontiers in cell and developmental biology 2021;9:800833
Single-Cell Analysis Identify Transcription Factor BACH1 as a Master Regulator Gene in Vascular Cells During Aging.
Ge F, Pan Q, Qin Y, Jia M, Ruan C, Wei X, Jing Q, Zhi X, Wang X, Jiang L, Osto E, Guo J, Meng D
Frontiers in cell and developmental biology 2021;9:786496
Frontiers in cell and developmental biology 2021;9:786496
p53-GSDME Elevation: A Path for CDK7 Inhibition to Suppress Breast Cancer Cell Survival.
Wang Y, Peng J, Mi X, Yang M
Frontiers in molecular biosciences 2021;8:697457
Frontiers in molecular biosciences 2021;8:697457
Hengshun Aromatic Vinegar Ameliorates Vascular Endothelial Injury via Regulating PKCζ-Mediated Oxidative Stress and Apoptosis.
Li X, Gao M, Zhu S, Yin L, Zhang B, Qi Y, Zhao Y, Yu Y, Xu L
Frontiers in nutrition 2021;8:635232
Frontiers in nutrition 2021;8:635232
Gentiopicroside Inhibits Cell Growth and Migration on Cervical Cancer via the Reciprocal MAPK/Akt Signaling Pathways.
Hu Z, Wang H, Fu Y, Ma K, Ma X, Wang J
Nutrition and cancer 2021;73(8):1459-1470
Nutrition and cancer 2021;73(8):1459-1470
Huxie Huaji Ointment Induced Apoptosis of Liver Cancer Cells In Vivo and In Vitro by Activating the Mitochondrial Pathway.
Cai Y, Du Q, Deng TH, Shen BB, Peng YM, Zeng PH, Yu SR
Evidence-based complementary and alternative medicine : eCAM 2021;2021:9922059
Evidence-based complementary and alternative medicine : eCAM 2021;2021:9922059
Escin Sodium Improves the Prognosis of Acute Pancreatitis via Promoting Cell Apoptosis by Suppression of the ERK/STAT3 Signaling Pathway.
Zhang Q, Zhao C, Zhang L, Sun K, Yu L, Wang X, Ren L, Zhang N, Chen C, Liu J, Wang H, Tian H
Oxidative medicine and cellular longevity 2021;2021:9921839
Oxidative medicine and cellular longevity 2021;2021:9921839
Metformin-Induced MicroRNA-34a-3p Downregulation Alleviates Senescence in Human Dental Pulp Stem Cells by Targeting CAB39 through the AMPK/mTOR Signaling Pathway.
Zhang S, Zhang R, Qiao P, Ma X, Lu R, Wang F, Li C, E L, Liu H
Stem cells international 2021;2021:6616240
Stem cells international 2021;2021:6616240
Design, Synthesis, and Biological Evaluation of a Novel Aminothiol Compound as Potential Radioprotector.
Li X, Wang X, Miao L, Guo Y, Yuan R, Ren J, Huang Y, Tian H
Oxidative medicine and cellular longevity 2021;2021:4714649
Oxidative medicine and cellular longevity 2021;2021:4714649
Oridonin Promotes Apoptosis and Restrains the Viability and Migration of Bladder Cancer by Impeding TRPM7 Expression via the ERK and AKT Signaling Pathways.
Che X, Zhan J, Zhao F, Zhong Z, Chen M, Han R, Wang Y
BioMed research international 2021;2021:4340950
BioMed research international 2021;2021:4340950
FAM134B-Mediated ER-phagy Upregulation Attenuates AGEs-Induced Apoptosis and Senescence in Human Nucleus Pulposus Cells.
Luo R, Li S, Li G, Lu S, Zhang W, Liu H, Lei J, Ma L, Ke W, Liao Z, Wang B, Song Y, Wang K, Zhang Y, Yang C
Oxidative medicine and cellular longevity 2021;2021:3843145
Oxidative medicine and cellular longevity 2021;2021:3843145
Novel biomarkers for post-contrast acute kidney injury identified from long non-coding RNA expression profiles.
Chen G, Liu B, Chen S, Li H, Liu J, Mai Z, Chen E, Zhou C, Sun G, Guo Z, Lei L, Huang S, Zhang L, Li M, Tan N, Li H, Liao Y, Liu J, Chen J, Liu Y
International journal of biological sciences 2021;17(3):882-896
International journal of biological sciences 2021;17(3):882-896
CDC20 regulates the cell proliferation and radiosensitivity of P53 mutant HCC cells through the Bcl-2/Bax pathway.
Zhao S, Zhang Y, Lu X, Ding H, Han B, Song X, Miao H, Cui X, Wei S, Liu W, Chen S, Wang J
International journal of biological sciences 2021;17(13):3608-3621
International journal of biological sciences 2021;17(13):3608-3621
p53 Promoted Ferroptosis in Ovarian Cancer Cells Treated with Human Serum Incubated-Superparamagnetic Iron Oxides.
Zhang Y, Xia M, Zhou Z, Hu X, Wang J, Zhang M, Li Y, Sun L, Chen F, Yu H
International journal of nanomedicine 2021;16:283-296
International journal of nanomedicine 2021;16:283-296
Delivery of Rapamycin by Liposomes Synergistically Enhances the Chemotherapy Effect of 5-Fluorouracil on Colorectal Cancer.
Chen YQ, Zhu WT, Lin CY, Yuan ZW, Li ZH, Yan PK
International journal of nanomedicine 2021;16:269-281
International journal of nanomedicine 2021;16:269-281
Computational Systems Pharmacology, Molecular Docking and Experiments Reveal the Protective Mechanism of Li-Da-Qian Mixture in the Treatment of Glomerulonephritis.
Zhou W, Sha Y, Zeng J, Zhang X, Zhang A, Ge X
Journal of inflammation research 2021;14:6939-6958
Journal of inflammation research 2021;14:6939-6958
RNA-binding Protein MBNL2 regulates Cancer Cell Metastasis through MiR-182-MBNL2-AKT Pathway.
Lin G, Li J, Cai J, Zhang H, Xin Q, Wang N, Xie W, Zhang Y, Xu N
Journal of Cancer 2021;12(22):6715-6726
Journal of Cancer 2021;12(22):6715-6726
Myricanol Inhibits Platelet Derived Growth Factor-BB-Induced Vascular Smooth Muscle Cells Proliferation and Migration in vitro and Intimal Hyperplasia in vivo by Targeting the Platelet-Derived Growth Factor Receptor-β and NF-κB Signaling.
Fan S, Wang C, Huang K, Liang M
Frontiers in physiology 2021;12:790345
Frontiers in physiology 2021;12:790345
Qingda Granule Attenuates Angiotensin II-Induced Renal Apoptosis and Activation of the p53 Pathway.
Long L, Zhang X, Wen Y, Li J, Wei L, Cheng Y, Liu H, Chu J, Fang Y, Xie Q, Shen A, Peng J
Frontiers in pharmacology 2021;12:770863
Frontiers in pharmacology 2021;12:770863
Decipering the Molecular Mechanism of ACE2 Regulating A549 Cells.
Xiao K, Song L, Bai Y, Liu P, Liu Y, Xie F, Xie L
Frontiers in genetics 2021;12:653725
Frontiers in genetics 2021;12:653725
A New Chalcone Derivative C49 Reverses Doxorubicin Resistance in MCF-7/DOX Cells by Inhibiting P-Glycoprotein Expression.
Wang T, Dong J, Yuan X, Wen H, Wu L, Liu J, Sui H, Deng W
Frontiers in pharmacology 2021;12:653306
Frontiers in pharmacology 2021;12:653306
Astragalin Inhibits the Proliferation and Migration of Human Colon Cancer HCT116 Cells by Regulating the NF-κB Signaling Pathway.
Yang M, Li WY, Xie J, Wang ZL, Wen YL, Zhao CC, Tao L, Li LF, Tian Y, Sheng J
Frontiers in pharmacology 2021;12:639256
Frontiers in pharmacology 2021;12:639256
A novel role of kallikrein-related peptidase 8 in the pathogenesis of diabetic cardiac fibrosis.
Du JK, Yu Q, Liu YJ, Du SF, Huang LY, Xu DH, Ni X, Zhu XY
Theranostics 2021;11(9):4207-4231
Theranostics 2021;11(9):4207-4231
Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance.
Zhao M, Wang Y, Li L, Liu S, Wang C, Yuan Y, Yang G, Chen Y, Cheng J, Lu Y, Liu J
Theranostics 2021;11(4):1845-1863
Theranostics 2021;11(4):1845-1863
Human umbilical cord-derived mesenchymal stem cell therapy ameliorates lupus through increasing CD4+ T cell senescence via MiR-199a-5p/Sirt1/p53 axis.
Cheng T, Ding S, Liu S, Li Y, Sun L
Theranostics 2021;11(2):893-905
Theranostics 2021;11(2):893-905
Elevated Sodium Pump α3 Subunit Expression Promotes Colorectal Liver Metastasis via the p53-PTEN/IGFBP3-AKT-mTOR Axis.
Wu D, Yu HQ, Xiong HJ, Zhang YJ, Lin XT, Zhang J, Wu W, Wang T, Liu XY, Xie CM
Frontiers in oncology 2021;11:743824
Frontiers in oncology 2021;11:743824
Targeting Mutated p53 Dependency in Triple-Negative Breast Cancer Cells Through CDK7 Inhibition.
Peng J, Yang M, Bi R, Wang Y, Wang C, Wei X, Zhang Z, Xie X, Wei W
Frontiers in oncology 2021;11:664848
Frontiers in oncology 2021;11:664848
Pterostilbene and its nicotinate derivative ameliorated vascular endothelial senescence and elicited endothelium-dependent relaxations via activation of sirtuin 1.
Zhang L, Zheng J, Tie X, Lin T, Yang W, Li Z, Zou Y, Guan G, Liu P, Luo W, Li Z
Canadian journal of physiology and pharmacology 2021 Sep;99(9):900-909
Canadian journal of physiology and pharmacology 2021 Sep;99(9):900-909
Iron deficiency exacerbates cisplatin- or rhabdomyolysis-induced acute kidney injury through promoting iron-catalyzed oxidative damage.
Zhao S, Wang X, Zheng X, Liang X, Wang Z, Zhang J, Zhao X, Zhuang S, Pan Q, Sun F, Shang W, Barasch J, Qiu A
Free radical biology & medicine 2021 Sep;173:81-96
Free radical biology & medicine 2021 Sep;173:81-96
A self-amplified nanocatalytic system for achieving "1 + 1 + 1 > 3" chemodynamic therapy on triple negative breast cancer.
Zhou L, Chen J, Sun Y, Chai K, Zhu Z, Wang C, Chen M, Han W, Hu X, Li R, Yao T, Li H, Dong C, Shi S
Journal of nanobiotechnology 2021 Sep 4;19(1):261
Journal of nanobiotechnology 2021 Sep 4;19(1):261
Treatment of early brain injury after subarachnoid hemorrhage in the rat model by inhibiting p53-induced ferroptosis.
Kuang H, Wang T, Liu L, Tang C, Li T, Liu M, Wang T, Zhong W, Wang Y
Neuroscience letters 2021 Sep 25;762:136134
Neuroscience letters 2021 Sep 25;762:136134
Increased tissue stiffness triggers contractile dysfunction and telomere shortening in dystrophic cardiomyocytes.
Chang ACY, Pardon G, Chang ACH, Wu H, Ong SG, Eguchi A, Ancel S, Holbrook C, Ramunas J, Ribeiro AJS, LaGory EL, Wang H, Koleckar K, Giaccia A, Mack DL, Childers MK, Denning C, Day JW, Wu JC, Pruitt BL, Blau HM
Stem cell reports 2021 Sep 14;16(9):2169-2181
Stem cell reports 2021 Sep 14;16(9):2169-2181
Effect of different exercise training intensities on age-related cardiac damage in male mice.
Pei Z, Yang C, Guo Y, Dong M, Wang F
Aging 2021 Sep 14;13(17):21700-21711
Aging 2021 Sep 14;13(17):21700-21711
Avicularin suppresses cartilage extracellular matrix degradation and inflammation via TRAF6/MAPK activation.
Zou ZL, Sun MH, Yin WF, Yang L, Kong LY
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Oct;91:153657
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Oct;91:153657
The protective effects of resveratrol pretreatment in cyclophosphamide-induced rat ovarian injury: an vivo study.
Nie Z, Zhang L, Chen W, Zhang Y, Wang W, Hua R, Zhang T, Zhao C, Gong M, Wu H
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2021 Oct;37(10):914-919
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2021 Oct;37(10):914-919
Advanced Maternal Age-associated SIRT1 Deficiency Compromises Trophoblast Epithelial-Mesenchymal Transition through an Increase in Vimentin Acetylation.
Xiong L, Ye X, Chen Z, Fu H, Li S, Xu P, Yu J, Wen L, Gao R, Fu Y, Qi H, Kilby MD, Saffery R, Baker PN, Tong C
Aging cell 2021 Oct;20(10):e13491
Aging cell 2021 Oct;20(10):e13491
Design, synthesis and antitumor evaluation of novel chiral diaryl substituted azetidin-2-one derivatives as tubulin polymerization inhibitors.
Liang Y, Zhang M, Zhou P, Liu M, Li J, Wang Y
Bioorganic chemistry 2021 Oct;115:105239
Bioorganic chemistry 2021 Oct;115:105239
The biological effect of cobalt chloride mimetic-hypoxia on nucleus pulposus cells and the comparability with physical hypoxia in vitro.
Gao XX, Liu CH, Hu ZL, Li HY, Chang X, Li YY, Zhang YY, Zhai Y, Li CQ
Frontiers in bioscience (Landmark edition) 2021 Oct 30;26(10):799-812
Frontiers in bioscience (Landmark edition) 2021 Oct 30;26(10):799-812
Chitosan oligosaccharides packaged into rat adipose mesenchymal stem cells-derived extracellular vesicles facilitating cartilage injury repair and alleviating osteoarthritis.
Li S, Liu J, Liu S, Jiao W, Wang X
Journal of nanobiotechnology 2021 Oct 26;19(1):343
Journal of nanobiotechnology 2021 Oct 26;19(1):343
The FOXM1/RNF26/p57 axis regulates the cell cycle to promote the aggressiveness of bladder cancer.
Yi L, Wang H, Li W, Ye K, Xiong W, Yu H, Jin X
Cell death & disease 2021 Oct 14;12(10):944
Cell death & disease 2021 Oct 14;12(10):944
Reactive Oxygen Species Mediate 6c-Induced Mitochondrial and Lysosomal Dysfunction, Autophagic Cell Death, and DNA Damage in Hepatocellular Carcinoma.
Wang S, Xu X, Che D, Fan R, Gao M, Cao Y, Ge C, Feng Y, Li J, Xie S, Wang C, Dai F, Gao L, Wang Y
International journal of molecular sciences 2021 Oct 12;22(20)
International journal of molecular sciences 2021 Oct 12;22(20)
GRIM-19 inhibits proliferation and induces apoptosis in a p53-dependent manner in colorectal cancer cells through the SIRT7/PCAF/MDM2 axis.
Wang D, Wei X, Chen X, Wang Q, Zhang J, Kalvakolanu DV, Guo B, Zhang L
Experimental cell research 2021 Oct 1;407(1):112799
Experimental cell research 2021 Oct 1;407(1):112799
A-24, a steroidal saponin from Allium chinense, induced apoptosis, autophagy and migration inhibition in p53 wild-type and p53-deficient gastric cancer cells.
Xu J, Wang Y, Wang Y, Wang Z, He X
Chemico-biological interactions 2021 Oct 1;348:109648
Chemico-biological interactions 2021 Oct 1;348:109648
Effects and Mechanisms of Synaptotagmin-7 in the Hippocampus on Cognitive Impairment in Aging Mice.
Xie Y, Zhi K, Meng X
Molecular neurobiology 2021 Nov;58(11):5756-5771
Molecular neurobiology 2021 Nov;58(11):5756-5771
Low-dose exposure to black carbon significantly increase lung injury of cadmium by promoting cellular apoptosis.
Wang L, Bao S, Liu X, Wang F, Zhang J, Dang P, Wang F, Li B, Lin Y
Ecotoxicology and environmental safety 2021 Nov;224:112703
Ecotoxicology and environmental safety 2021 Nov;224:112703
Betaine alleviates right ventricular failure via regulation of Rho A/ROCK signaling pathway in rats with pulmonary arterial hypertension.
Lv Y, Ma P, Wang J, Xu Q, Fan J, Yan L, Ma P, Zhou R
European journal of pharmacology 2021 Nov 5;910:174311
European journal of pharmacology 2021 Nov 5;910:174311
Protective Effects of L-Theanine on IPEC-J2 Cells Growth Inhibition Induced by Dextran Sulfate Sodium via p53 Signaling Pathway.
Zhang L, Ma M, Li Z, Zhang H, He X, Song Z
Molecules (Basel, Switzerland) 2021 Nov 19;26(22)
Molecules (Basel, Switzerland) 2021 Nov 19;26(22)
The Y14-p53 regulatory circuit in megakaryocyte differentiation and thrombocytopenia.
Su CH, Liao WJ, Ke WC, Yang RB, Tarn WY
iScience 2021 Nov 19;24(11):103368
iScience 2021 Nov 19;24(11):103368
miR-6745-TIMP1 axis inhibits cell growth and metastasis in gastric cancer.
Liu H, Xiang Y, Zong QB, Zhang XY, Wang ZW, Fang SQ, Zhang TC, Liao XH
Aging 2021 Nov 14;13(21):24402-24416
Aging 2021 Nov 14;13(21):24402-24416
Protection of the enhanced Nrf2 deacetylation and its downstream transcriptional activity by SIRT1 in myocardial ischemia/reperfusion injury.
Xu JJ, Cui J, Lin Q, Chen XY, Zhang J, Gao EH, Wei B, Zhao W
International journal of cardiology 2021 Nov 1;342:82-93
International journal of cardiology 2021 Nov 1;342:82-93
Nicotinamide Supplementation Attenuates Renal Interstitial Fibrosis via Boosting the Activity of Sirtuins.
Zhen X, Zhang S, Xie F, Zhou M, Hu Z, Zhu F, Nie J
Kidney diseases (Basel, Switzerland) 2021 May;7(3):186-199
Kidney diseases (Basel, Switzerland) 2021 May;7(3):186-199
MFG-E8 regulated by miR-99b-5p protects against osteoarthritis by targeting chondrocyte senescence and macrophage reprogramming via the NF-κB pathway.
Lu Y, Liu L, Pan J, Luo B, Zeng H, Shao Y, Zhang H, Guan H, Guo D, Zeng C, Zhang R, Bai X, Zhang H, Cai D
Cell death & disease 2021 May 25;12(6):533
Cell death & disease 2021 May 25;12(6):533
LncRNA CD27-AS1 promotes acute myeloid leukemia progression through the miR-224-5p/PBX3 signaling circuit.
Tao Y, Zhang J, Chen L, Liu X, Yao M, Zhang H
Cell death & disease 2021 May 18;12(6):510
Cell death & disease 2021 May 18;12(6):510
AIMP3 inhibits cell growth and metastasis of lung adenocarcinoma through activating a miR-96-5p-AIMP3-p53 axis.
Ding L, Fang Y, Li Y, Hu Q, Ai M, Deng K, Huang X, Xin H
Journal of cellular and molecular medicine 2021 Mar;25(6):3019-3030
Journal of cellular and molecular medicine 2021 Mar;25(6):3019-3030
Melatonin inhibits proliferation and viability and promotes apoptosis in colorectal cancer cells via upregulation of the microRNA-34a/449a cluster.
Ji G, Zhou W, Li X, Du J, Li X, Hao H
Molecular medicine reports 2021 Mar;23(3)
Molecular medicine reports 2021 Mar;23(3)
Sodium hydrosulfide alleviates dexamethasone-induced cell senescence and dysfunction through targeting the miR-22/sirt1 pathway in osteoblastic MC3T3-E1 cells.
Li P, Mao WW, Zhang S, Zhang L, Chen ZR, Lu ZD
Experimental and therapeutic medicine 2021 Mar;21(3):238
Experimental and therapeutic medicine 2021 Mar;21(3):238
Metformin attenuates hyperlipidaemia-associated vascular calcification through anti-ferroptotic effects.
Ma WQ, Sun XJ, Zhu Y, Liu NF
Free radical biology & medicine 2021 Mar;165:229-242
Free radical biology & medicine 2021 Mar;165:229-242
Aberrant elevation of GDF8 impairs granulosa cell glucose metabolism via upregulating SERPINE1 expression in patients with PCOS.
Bai L, Wang W, Xiang Y, Wang S, Wan S, Zhu Y
Molecular therapy. Nucleic acids 2021 Mar 5;23:294-309
Molecular therapy. Nucleic acids 2021 Mar 5;23:294-309
BMP5 silencing inhibits chondrocyte senescence and apoptosis as well as osteoarthritis progression in mice.
Shao Y, Zhao C, Pan J, Zeng C, Zhang H, Liu L, Fan K, Liu X, Luo B, Fang H, Bai X, Zhang H, Cai D
Aging 2021 Mar 19;13(7):9646-9664
Aging 2021 Mar 19;13(7):9646-9664
Pregnane X receptor (PXR) protects against cisplatin-induced acute kidney injury in mice.
Luan Z, Wei Y, Huo X, Sun X, Zhang C, Ming W, Luo Z, Du C, Li Y, Xu H, Lu H, Zheng F, Guan Y, Zhang X
Biochimica et biophysica acta. Molecular basis of disease 2021 Mar 1;1867(3):165996
Biochimica et biophysica acta. Molecular basis of disease 2021 Mar 1;1867(3):165996
Key proteins of proteome underlying sperm malformation of rats exposed to low fenvalerate doses are highly related to P53.
Huang S, Lu Y, Li S, Zhou T, Wang J, Xia J, Zhang X, Zhou Z
Environmental toxicology 2021 Jun;36(6):1181-1194
Environmental toxicology 2021 Jun;36(6):1181-1194
The p53/NF-kappaB-dependent induction of sestrin2 by amyloid-beta peptides exerts antioxidative actions in neurons.
Hsieh YH, Chao AC, Lin YC, Chen SD, Yang DI
Free radical biology & medicine 2021 Jun;169:36-61
Free radical biology & medicine 2021 Jun;169:36-61
Paricalcitol inhibits oxidative stress-induced cell senescence of the bile duct epithelium dependent on modulating Sirt1 pathway in cholestatic mice.
Jia R, Yang F, Yan P, Ma L, Yang L, Li L
Free radical biology & medicine 2021 Jun;169:158-168
Free radical biology & medicine 2021 Jun;169:158-168
Frame-shift mediated reduction of gain-of-function p53 R273H and deletion of the R273H C-terminus in breast cancer cells result in replication-stress sensitivity.
Ellison V, Annor GK, Freedman C, Xiao G, Lundine D, Freulich E, Prives C, Bargonetti J
Oncotarget 2021 Jun 8;12(12):1128-1146
Oncotarget 2021 Jun 8;12(12):1128-1146
PRDX2 promotes the proliferation of colorectal cancer cells by increasing the ubiquitinated degradation of p53.
Wang W, Wei J, Zhang H, Zheng X, Zhou H, Luo Y, Yang J, Deng Q, Huang S, Fu Z
Cell death & disease 2021 Jun 11;12(6):605
Cell death & disease 2021 Jun 11;12(6):605
ND‑09 inhibits chronic myeloid leukemia K562 cell growth by regulating BCR‑ABL signaling.
Liu YH, Zhu M, Lei PP, Pan XY, Ma WN
Oncology reports 2021 Jul;46(1)
Oncology reports 2021 Jul;46(1)
Electroacupuncture at GV20‑GB7 regulates mitophagy to protect against neurological deficits following intracerebral hemorrhage via inhibition of apoptosis.
Guan R, Li Z, Dai X, Zou W, Yu X, Liu H, Chen Q, Teng W, Liu P, Liu X, Dong S
Molecular medicine reports 2021 Jul;24(1)
Molecular medicine reports 2021 Jul;24(1)
The Protective Effects of Parathyroid Hormone (1-34) on Cartilage and Subchondral Bone Through Down-Regulating JAK2/STAT3 and WNT5A/ROR2 in a Collagenase-Induced Osteoarthritis Mouse Model.
Shao LT, Gou Y, Fang JK, Hu YP, Lian QQ, Yang Z, Zhang YY, Wang YD, Tian FM, Zhang L
Orthopaedic surgery 2021 Jul;13(5):1662-1672
Orthopaedic surgery 2021 Jul;13(5):1662-1672
Phosphorylation of RCC1 on Serine 11 Facilitates G1/S Transition in HPV E7-Expressing Cells.
Hou X, Qiao L, Liu R, Han X, Zhang W
Biomolecules 2021 Jul 6;11(7)
Biomolecules 2021 Jul 6;11(7)
HO-1 nuclear accumulation and interaction with NPM1 protect against stress-induced endothelial senescence independent of its enzymatic activity.
Luo W, Li J, Li Z, Lin T, Zhang L, Yang W, Mai Y, Liu R, Chen M, Dai C, Yang H, Lu J, Li H, Guan G, Huang M, Liu P, Li Z
Cell death & disease 2021 Jul 26;12(8):738
Cell death & disease 2021 Jul 26;12(8):738
Hypoxic preconditioning rejuvenates mesenchymal stem cells and enhances neuroprotection following intracerebral hemorrhage via the miR-326-mediated autophagy.
Liu J, He J, Ge L, Xiao H, Huang Y, Zeng L, Jiang Z, Lu M, Hu Z
Stem cell research & therapy 2021 Jul 22;12(1):413
Stem cell research & therapy 2021 Jul 22;12(1):413
Telomere dysfunction instigates inflammation in inflammatory bowel disease.
Chakravarti D, Lee R, Multani AS, Santoni A, Keith Z, Hsu WH, Chang K, Reyes L, Rashid A, Wu CJ, Li J, Zhang J, Shim HS, Chandra K, Deng P, Spring DJ, Nielsen OH, Riis LB, Mayigegowda KK, Blutt SE, Zhang J, Younes M, DuPont A, Thirumurthi S, Vilar E, Estes MK, Colla S, Shroyer NF, DePinho RA
Proceedings of the National Academy of Sciences of the United States of America 2021 Jul 20;118(29)
Proceedings of the National Academy of Sciences of the United States of America 2021 Jul 20;118(29)
Role of ferroptosis induced by a high concentration of calcium oxalate in the formation and development of urolithiasis.
He Z, Liao W, Song Q, Li B, Liu J, Xiong Y, Song C, Yang S
International journal of molecular medicine 2021 Jan;47(1):289-301
International journal of molecular medicine 2021 Jan;47(1):289-301
Avasimibe exerts anticancer effects on human glioblastoma cells via inducing cell apoptosis and cell cycle arrest.
Liu JY, Fu WQ, Zheng XJ, Li W, Ren LW, Wang JH, Yang C, Du GH
Acta pharmacologica Sinica 2021 Jan;42(1):97-107
Acta pharmacologica Sinica 2021 Jan;42(1):97-107
Antitumor effects of dioscin in A431 cells via adjusting ATM/p53-mediated cell apoptosis, DNA damage and migration.
Wang P, Wang C, Liu C
Oncology letters 2021 Jan;21(1):59
Oncology letters 2021 Jan;21(1):59
Ubiquitin-specific protease 7 promotes ferroptosis via activation of the p53/TfR1 pathway in the rat hearts after ischemia/reperfusion.
Tang LJ, Zhou YJ, Xiong XM, Li NS, Zhang JJ, Luo XJ, Peng J
Free radical biology & medicine 2021 Jan;162:339-352
Free radical biology & medicine 2021 Jan;162:339-352
miRNA-146a-5p mitigates stress-induced premature senescence of D-galactose-induced primary thymic stromal cells.
Du H, Wang Y, Liu X, Wang S, Wu S, Yuan Z, Zhu X
Cytokine 2021 Jan;137:155314
Cytokine 2021 Jan;137:155314
Huaier Inhibits Proliferation, Migration, and Invasion of Cutaneous Squamous Cell Carcinoma Cells by Inhibiting the Methylation Levels of CDKN2A and TP53.
Wang L, Xu L, Wang Y
Integrative cancer therapies 2021 Jan-Dec;20:15347354211031646
Integrative cancer therapies 2021 Jan-Dec;20:15347354211031646
Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuate Mitochondrial Damage and Inflammation by Stabilizing Mitochondrial DNA.
Zhao M, Liu S, Wang C, Wang Y, Wan M, Liu F, Gong M, Yuan Y, Chen Y, Cheng J, Lu Y, Liu J
ACS nano 2021 Jan 26;15(1):1519-1538
ACS nano 2021 Jan 26;15(1):1519-1538
Autophagy augments the self-renewal of lung cancer stem cells by the degradation of ubiquitinated p53.
Wang J, Liu D, Sun Z, Ye T, Li J, Zeng B, Zhao Q, Rosie Xing H
Cell death & disease 2021 Jan 19;12(1):98
Cell death & disease 2021 Jan 19;12(1):98
Protective effect of thioredoxin reductase 1 in Parkinson's disease.
Liu Z, Ye Q, Wang F, Guo Y, Cui R, Wang J, Wang D
Neuroscience letters 2021 Jan 10;741:135457
Neuroscience letters 2021 Jan 10;741:135457
Death by histone deacetylase inhibitor quisinostat in tongue squamous cell carcinoma via apoptosis, pyroptosis, and ferroptosis.
Wang X, Liu K, Gong H, Li D, Chu W, Zhao D, Wang X, Xu D
Toxicology and applied pharmacology 2021 Jan 1;410:115363
Toxicology and applied pharmacology 2021 Jan 1;410:115363
Effects of redox interference on the pancreatic mitochondria and the abnormal blood glucose.
Xie F, Wu M, Lai B, Halim M, Liu S, Shi D
Free radical research 2021 Feb;55(2):119-130
Free radical research 2021 Feb;55(2):119-130
The distinct roles of myosin IIA and IIB under compression stress in nucleus pulposus cells.
Ke W, Wang B, Hua W, Song Y, Lu S, Luo R, Li G, Wang K, Liao Z, Xiang Q, Li S, Wu X, Zhang Y, Yang C
Cell proliferation 2021 Feb;54(2):e12987
Cell proliferation 2021 Feb;54(2):e12987
Piezo type mechanosensitive ion channel component 1 facilitates gastric cancer omentum metastasis.
Wang X, Cheng G, Miao Y, Qiu F, Bai L, Gao Z, Huang Y, Dong L, Niu X, Wang X, Li Y, Tang H, Xu Y, Song X
Journal of cellular and molecular medicine 2021 Feb;25(4):2238-2253
Journal of cellular and molecular medicine 2021 Feb;25(4):2238-2253
RabGEF1 functions as an oncogene in U251 glioblastoma cells and is involved in regulating AKT and Erk pathways.
Fan H, Xin T, Dong X, Yang F, Zhang R, Feng S, He D, Guo H, Pang Q
Experimental and molecular pathology 2021 Feb;118:104571
Experimental and molecular pathology 2021 Feb;118:104571
TRPV1 Activation Promotes β-arrestin2 Interaction with the Ribosomal Biogenesis Machinery in the Nucleolus:Implications for p53 Regulation and Neurite Outgrowth.
Hassan A, Iftinca M, Young D, Flynn R, Agosti F, Abdullah N, Defaye M, Scott MGH, Dufour A, Altier C
International journal of molecular sciences 2021 Feb 25;22(5)
International journal of molecular sciences 2021 Feb 25;22(5)
Red ginseng has stronger anti-aging effects compared to ginseng possibly due to its regulation of oxidative stress and the gut microbiota.
Peng X, Hao M, Zhao Y, Cai Y, Chen X, Chen H, Zhang Y, Dong L, Liu X, Ding C, Liu W, Yang M, Luo Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Dec;93:153772
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Dec;93:153772
Exercise downregulates HIPK2 and HIPK2 inhibition protects against myocardial infarction.
Zhou Q, Deng J, Yao J, Song J, Meng D, Zhu Y, Xu M, Liang Y, Xu J, Sluijter JP, Xiao J
EBioMedicine 2021 Dec;74:103713
EBioMedicine 2021 Dec;74:103713
Simiao Qingwen Baidu decoction inhibits Epstein-Barr virus-induced B lymphoproliferative disease and lytic viral replication.
Yang X, Liu L, Zhang H, Sun X, Yan Y, Ran R
Pharmaceutical biology 2021 Dec;59(1):741-747
Pharmaceutical biology 2021 Dec;59(1):741-747
Non-Structural Protein 5 of Zika Virus Interacts with p53 in Human Neural Progenitor Cells and Induces p53-Mediated Apoptosis.
Li P, Jiang H, Peng H, Zeng W, Zhong Y, He M, Xie L, Chen J, Guo D, Wu J, Li CM
Virologica Sinica 2021 Dec;36(6):1411-1420
Virologica Sinica 2021 Dec;36(6):1411-1420
Effects and mechanisms of probucol on aging-related hippocampus-dependent cognitive impairment.
Xie Y, Song A, Zhu Y, Jiang A, Peng W, Zhang C, Meng X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Dec;144:112266
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Dec;144:112266
Deficiency of β-arrestin2 alleviates apoptosis through GRP78-ATF6-CHOP signaling pathway in primary Sjögren's syndrome.
Huang L, Liu Q, Zhou T, Zhang J, Tian Q, Zhang Q, Wei W, Wu H
International immunopharmacology 2021 Dec;101(Pt A):108281
International immunopharmacology 2021 Dec;101(Pt A):108281
CCT8 recovers WTp53-suppressed cell cycle evolution and EMT to promote colorectal cancer progression.
Liao Q, Ren Y, Yang Y, Zhu X, Zhi Y, Zhang Y, Chen Y, Ding Y, Zhao L
Oncogenesis 2021 Dec 3;10(12):84
Oncogenesis 2021 Dec 3;10(12):84
IGFBP7-AS1 is a p53-responsive long noncoding RNA downregulated by Epstein-Barr virus that contributes to viral tumorigenesis.
Dang W, Cao P, Yan Q, Yang L, Wang Y, Yang J, Xin S, Zhang J, Li J, Long S, Zhang W, Zhang S, Lu J
Cancer letters 2021 Dec 28;523:135-147
Cancer letters 2021 Dec 28;523:135-147
The degradation of Rap1GAP via E6AP-mediated ubiquitin-proteasome pathway is associated with HPV16/18-infection in cervical cancer cells.
Wang Y, Xie Y, Sun B, Guo Y, Song L, Mohammednur DE, Zhao C
Infectious agents and cancer 2021 Dec 24;16(1):71
Infectious agents and cancer 2021 Dec 24;16(1):71
Endoderm development requires centrioles to restrain p53-mediated apoptosis in the absence of ERK activity.
Xie C, Abrams SR, Herranz-Pérez V, García-Verdugo JM, Reiter JF
Developmental cell 2021 Dec 20;56(24):3334-3348.e6
Developmental cell 2021 Dec 20;56(24):3334-3348.e6
Oxygen nanocarrier broke the hypoxia trap of solid tumors and rescued transfection efficiency for gene therapy.
Qin B, Jiang M, Li X, Shi Y, Zhang J, Luo Z, Luo L, Lu Y, Liu X, Wang S, Du Y, Qiu Y, Lou Y, You J
Journal of nanobiotechnology 2021 Dec 18;19(1):427
Journal of nanobiotechnology 2021 Dec 18;19(1):427
Protective Effect of l-Theanine against DSS-Induced Colitis by Regulating the Lipid Metabolism and Reducing Inflammation via the NF-κB Signaling Pathway.
Zhang L, Yao X, Ma M, Ding Y, Zhang H, He X, Song Z
Journal of agricultural and food chemistry 2021 Dec 1;69(47):14192-14203
Journal of agricultural and food chemistry 2021 Dec 1;69(47):14192-14203
Genomic gain of RRS1 promotes hepatocellular carcinoma through reducing the RPL11-MDM2-p53 signaling.
Cao P, Yang A, Li P, Xia X, Han Y, Zhou G, Wang R, Yang F, Li Y, Zhang Y, Cui Y, Ji H, Lu L, He F, Zhou G
Science advances 2021 Aug;7(35)
Science advances 2021 Aug;7(35)
P53 inhibitor pifithrin-α inhibits ropivacaine-induced neuronal apoptosis via the mitochondrial apoptosis pathway.
Zeng L, Zhang F, Zhang Z, Xu M, Xu Y, Liu Y, Xu H, Sun X, Sang M, Luo H
Journal of biochemical and molecular toxicology 2021 Aug;35(8):e22822
Journal of biochemical and molecular toxicology 2021 Aug;35(8):e22822
Ring finger protein 19A is overexpressed in non-small cell lung cancer and mediates p53 ubiquitin-degradation to promote cancer growth.
Cheng Y, Hu Y, Wang H, Zhao Z, Jiang X, Zhang Y, Zhang J, Tong Y, Qiu X
Journal of cellular and molecular medicine 2021 Aug;25(16):7796-7808
Journal of cellular and molecular medicine 2021 Aug;25(16):7796-7808
Design, synthesis and biological evaluation of novel 2,4-disubstituted quinazoline derivatives targeting H1975 cells via EGFR-PI3K signaling pathway.
Wang Z, Liu L, Dai H, Si X, Zhang L, Li E, Yang Z, Chao G, Zheng J, Ke Y, Lihong S, Zhang Q, Liu H
Bioorganic & medicinal chemistry 2021 Aug 1;43:116265
Bioorganic & medicinal chemistry 2021 Aug 1;43:116265
MicroRNA-22 contributes to dexamethasone-induced osteoblast differentiation inhibition and dysfunction through targeting caveolin-3 expression in osteoblastic cells.
Li P, Mao W, Zhang S, Zhang L, Chen Z, Lu Z
Experimental and therapeutic medicine 2021 Apr;21(4):336
Experimental and therapeutic medicine 2021 Apr;21(4):336
A novel amphibian-derived peptide alleviated ultraviolet B-induced photodamage in mice.
Zhang X, Feng C, Wang S, Wang Y, Fu Z, Zhang Y, Sun H, Xie C, Fu Y, Tao J, Luo M, Yang X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Apr;136:111258
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Apr;136:111258
Inhibition of the P53/P21 Pathway Attenuates the Effects of Senescent Nucleus Pulposus Cell-Derived Exosomes on the Senescence of Nucleus Pulposus Cells.
Chen CC, Chen J, Wang WL, Xie L, Shao CQ, Zhang YX
Orthopaedic surgery 2021 Apr;13(2):583-591
Orthopaedic surgery 2021 Apr;13(2):583-591
ASIC1 and ASIC3 mediate cellular senescence of human nucleus pulposus mesenchymal stem cells during intervertebral disc degeneration.
Ding J, Zhang R, Li H, Ji Q, Cheng X, Thorne RF, Hondermarck H, Liu X, Shen C
Aging 2021 Apr 6;13(7):10703-10723
Aging 2021 Apr 6;13(7):10703-10723
Knockdown of TRIM32 inhibits tumor growth and increases the therapeutic sensitivity to temozolomide in glioma in a p53-dependent and -independent manner.
Cai Y, Gu WT, Cheng K, Jia PF, Li F, Wang M, Zhang WF, Qiu JT, Wu ZB, Zhao WG
Biochemical and biophysical research communications 2021 Apr 23;550:134-141
Biochemical and biophysical research communications 2021 Apr 23;550:134-141
Withanolides from dietary tomatillo suppress HT1080 cancer cell growth by targeting mutant IDH1.
Yang Y, Xiang K, Sun D, Zheng M, Song Z, Li M, Wang X, Li H, Chen L
Bioorganic & medicinal chemistry 2021 Apr 15;36:116095
Bioorganic & medicinal chemistry 2021 Apr 15;36:116095
p53-targeted lncRNA ST7-AS1 acts as a tumour suppressor by interacting with PTBP1 to suppress the Wnt/β-catenin signalling pathway in glioma.
Sheng J, He X, Yu W, Chen Y, Long Y, Wang K, Zhu S, Liu Q
Cancer letters 2021 Apr 10;503:54-68
Cancer letters 2021 Apr 10;503:54-68
Polychlorinated biphenyl quinone regulates MLKL phosphorylation that stimulates exosome biogenesis and secretion via a short negative feedback loop.
Peng L, Wang Y, Yang B, Qin Q, Song E, Song Y
Environmental pollution (Barking, Essex : 1987) 2021 Apr 1;274:115606
Environmental pollution (Barking, Essex : 1987) 2021 Apr 1;274:115606
PAQR3 Inhibits Non-small Cell Lung Cancer Growth by Regulating the NF-κB/p53/Bax Axis.
Guo Q, Ke XX, Fang SX, Gao WL, Song YX, Chen C, Lu HL, Xu G
Frontiers in cell and developmental biology 2020;8:581919
Frontiers in cell and developmental biology 2020;8:581919
Piperlongumine Attenuates High Calcium/Phosphate-Induced Arterial Calcification by Preserving P53/PTEN Signaling.
Shi W, Lu J, Li J, Qiu M, Lu Y, Gu J, Kong X, Sun W
Frontiers in cardiovascular medicine 2020;7:625215
Frontiers in cardiovascular medicine 2020;7:625215
Comparison of anticarcinogenic properties of Viburnum opulus and its active compound p-coumaric acid on human colorectal carcinoma.
Karakurt S, AbuŞoĞlu G, Arituluk ZC
Turkish journal of biology = Turk biyoloji dergisi 2020;44(5):252-263
Turkish journal of biology = Turk biyoloji dergisi 2020;44(5):252-263
AURKA Increase the Chemosensitivity of Colon Cancer Cells to Oxaliplatin by Inhibiting the TP53-Mediated DNA Damage Response Genes.
Shan B, Zhao R, Zhou J, Zhang M, Qi X, Wang T, Gong J, Wu Y, Zhu Y, Yang W, Zhang Y, Wang G, Li X
BioMed research international 2020;2020:8916729
BioMed research international 2020;2020:8916729
Aging Induced p53/p21 in Genioglossus Muscle Stem Cells and Enhanced Upper Airway Injury.
Zhu LY, Yu LM, Zhang WH, Deng JJ, Liu SF, Huang W, Zhang MH, Lu YQ, Han XX, Liu YH
Stem cells international 2020;2020:8412598
Stem cells international 2020;2020:8412598
The Establishment of Esophageal Precancerous Lesion Model by Using p53 Conditional Knockout Mouse in Esophageal Epithelium.
Zhu L, Xu Y, Chen X, Qin J, Niu T, Zhu Y, Jiang Y, Zhao S, Liu K, Lu J, Jin G, Ma J, Dong Z, Zhao J
BioMed research international 2020;2020:4534289
BioMed research international 2020;2020:4534289
Protective Effects of Cinnamaldehyde against Mesenteric Ischemia-Reperfusion-Induced Lung and Liver Injuries in Rats.
Almoiliqy M, Wen J, Qaed E, Sun Y, Lian M, Mousa H, Al-Azab M, Zaky MY, Chen D, Wang L, Al-Sharabi A, Liu Z, Sun P, Lin Y
Oxidative medicine and cellular longevity 2020;2020:4196548
Oxidative medicine and cellular longevity 2020;2020:4196548
Silencing of ELK3 Induces S-M Phase Arrest and Apoptosis and Upregulates SERPINE1 Expression Reducing Migration in Prostate Cancer Cells.
Mao Y, Li W, Hua B, Gu X, Pan W, Chen Q, Xu B, Wang Z, Lu C
BioMed research international 2020;2020:2406159
BioMed research international 2020;2020:2406159
MFP-FePt-GO Nanocomposites Promote Radiosensitivity of Non-Small Cell Lung Cancer Via Activating Mitochondrial-Mediated Apoptosis and Impairing DNA Damage Repair.
Peng S, Sun Y, Luo Y, Ma S, Sun W, Tang G, Li S, Zhang N, Ren J, Xiao Y, Liu X, Zhang J, Gong Y, Xie C
International journal of biological sciences 2020;16(12):2145-2158
International journal of biological sciences 2020;16(12):2145-2158
miR-370-3p Alleviates Ulcerative Colitis-Related Colorectal Cancer in Mice Through Inhibiting the Inflammatory Response and Epithelial-Mesenchymal Transition.
Lin L, Wang D, Qu S, Zhao H, Lin Y
Drug design, development and therapy 2020;14:1127-1141
Drug design, development and therapy 2020;14:1127-1141
Kidney and lung tissue modifications after BDL-induced liver injury in mice are associated with increased expression of IGFBPrP1 and activation of the NF-κB inflammation pathway.
Hu ZH, Kong YY, Ren JJ, Huang TJ, Wang YQ, Liu LX
International journal of clinical and experimental pathology 2020;13(2):192-202
International journal of clinical and experimental pathology 2020;13(2):192-202
GCNT4 is Associated with Prognosis and Suppress Cell Proliferation in Gastric Cancer.
Sun H, Chang J, Ye M, Weng W, Zhang M, Ni S, Tan C, Huang D, Wang L, Du X, Xu MD, Sheng W
OncoTargets and therapy 2020;13:8601-8613
OncoTargets and therapy 2020;13:8601-8613
The Acetone Indigo Red Dehydrating Agent IF203 Induces HepG2 Cell Death Through Cell Cycle Arrest, Autophagy and Apoptosis.
Shang Y, Wang Q, Li J, Zhao Q, Huang X, Dong H, Liu H, Zhang Y, Zhang J, Gui R, Nie X
OncoTargets and therapy 2020;13:473-486
OncoTargets and therapy 2020;13:473-486
Fibroblast Activation Protein (FAP) Overexpression Induces Epithelial-Mesenchymal Transition (EMT) in Oral Squamous Cell Carcinoma by Down-Regulating Dipeptidyl Peptidase 9 (DPP9).
Wu QQ, Zhao M, Huang GZ, Zheng ZN, Chen Y, Zeng WS, Lv XZ
OncoTargets and therapy 2020;13:2599-2611
OncoTargets and therapy 2020;13:2599-2611
Overexpression of RNF126 Promotes the Development of Colorectal Cancer via Enhancing p53 Ubiquitination and Degradation.
Wang S, Wang T, Wang L, Zhong L, Li K
OncoTargets and therapy 2020;13:10917-10929
OncoTargets and therapy 2020;13:10917-10929
Down-regulation of USP8 Inhibits Cholangiocarcinoma Cell Proliferation and Invasion.
Jing X, Chen Y, Chen Y, Shi G, Lv S, Cheng N, Feng C, Xin Z, Zhang L, Wu J
Cancer management and research 2020;12:2185-2194
Cancer management and research 2020;12:2185-2194
Chlorogenic Acid Decreases Malignant Characteristics of Hepatocellular Carcinoma Cells by Inhibiting DNMT1 Expression.
Liu Y, Feng Y, Li Y, Hu Y, Zhang Q, Huang Y, Shi K, Ran C, Hou J, Zhou G, Wang X
Frontiers in pharmacology 2020;11:867
Frontiers in pharmacology 2020;11:867
STRAP as a New Therapeutic Target for Poor Prognosis of Pancreatic Ductal Adenocarcinoma Patients Mainly Caused by TP53 Mutation.
Hu S, Chen X, Xu X, Zheng C, Huang W, Zhou Y, Akuetteh PDP, Yang H, Shi K, Chen B, Zhang Q
Frontiers in oncology 2020;10:594224
Frontiers in oncology 2020;10:594224
Transcription Factor EBF1 Over-Expression Suppresses Tumor Growth in vivo and in vitro via Modulation of the PNO1/p53 Pathway in Colorectal Cancer.
Shen Z, Chen Y, Li L, Liu L, Peng M, Chen X, Wu X, Sferra TJ, Wu M, Lin X, Cheng Y, Chu J, Shen A, Peng J
Frontiers in oncology 2020;10:1035
Frontiers in oncology 2020;10:1035
Effect of epiberberine from Coptis chinensis Franch on inhibition of tumor growth in MKN-45 xenograft mice.
Yu M, Ren L, Liang F, Zhang Y, Jiang L, Ma W, Li C, Li X, Ye X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 Sep;76:153216
Phytomedicine : international journal of phytotherapy and phytopharmacology 2020 Sep;76:153216
Cinnamaldehyde protects against rat intestinal ischemia/reperfusion injuries by synergistic inhibition of NF-κB and p53.
Almoiliqy M, Wen J, Xu B, Sun YC, Lian MQ, Li YL, Qaed E, Al-Azab M, Chen DP, Shopit A, Wang L, Sun PY, Lin Y
Acta pharmacologica Sinica 2020 Sep;41(9):1208-1222
Acta pharmacologica Sinica 2020 Sep;41(9):1208-1222
Musashi2 promotes the progression of pancreatic cancer through a novel ISYNA1-p21/ZEB-1 pathway.
Zhou L, Sheng W, Jia C, Shi X, Cao R, Wang G, Lin Y, Zhu F, Dong Q, Dong M
Journal of cellular and molecular medicine 2020 Sep;24(18):10560-10572
Journal of cellular and molecular medicine 2020 Sep;24(18):10560-10572
Antitumor effects of aconitine in A2780 cells via estrogen receptor β‑mediated apoptosis, DNA damage and migration.
Wang X, Lin Y, Zheng Y
Molecular medicine reports 2020 Sep;22(3):2318-2328
Molecular medicine reports 2020 Sep;22(3):2318-2328
A steroidal saponin isolated from Allium chinense simultaneously induces apoptosis and autophagy by modulating the PI3K/Akt/mTOR signaling pathway in human gastric adenocarcinoma.
Xu J, Zhang M, Lin X, Wang Y, He X
Steroids 2020 Sep;161:108672
Steroids 2020 Sep;161:108672
Synthesis, docking studies and antitumor activity of phenanthroimidazole derivatives as promising c-myc G-quadruplex DNA stabilizers.
Wu Q, Song Y, Liu R, Wang R, Mei W, Chen W, Yang H, Wang X
Bioorganic chemistry 2020 Sep;102:104074
Bioorganic chemistry 2020 Sep;102:104074
Abnormal expression of homeobox c6 in the atherosclerotic aorta and its effect on proliferation and migration of rat vascular smooth muscle cells.
Long X, You G, Wu Q, Zhou Y, Yu F, Xiao Y, Deng S, Song F, Huang J, Tian M
Acta biochimica et biophysica Sinica 2020 Sep 8;52(9):935-943
Acta biochimica et biophysica Sinica 2020 Sep 8;52(9):935-943
lncRNA STEAP3-AS1 Modulates Cell Cycle Progression via Affecting CDKN1C Expression through STEAP3 in Colon Cancer.
Na H, Li X, Zhang X, Xu Y, Sun Y, Cui J, Chen Z, Shi X, Ren S, Zuo Y
Molecular therapy. Nucleic acids 2020 Sep 4;21:480-491
Molecular therapy. Nucleic acids 2020 Sep 4;21:480-491
RFX5 promotes the progression of hepatocellular carcinoma through transcriptional activation of KDM4A.
Chen DB, Xie XW, Zhao YJ, Wang XY, Liao WJ, Chen P, Deng KJ, Fei R, Qin WY, Wang JH, Wu X, Shao QX, Wei L, Chen HS
Scientific reports 2020 Sep 3;10(1):14538
Scientific reports 2020 Sep 3;10(1):14538
PTEN status determines chemosensitivity to proteasome inhibition in cholangiocarcinoma.
Jiang TY, Pan YF, Wan ZH, Lin YK, Zhu B, Yuan ZG, Ma YH, Shi YY, Zeng TM, Dong LW, Tan YX, Wang HY
Science translational medicine 2020 Sep 23;12(562)
Science translational medicine 2020 Sep 23;12(562)
Targeting DNA to the endoplasmic reticulum efficiently enhances gene delivery and therapy.
Qin B, Yuan X, Jiang M, Yin H, Luo Z, Zhang J, Zhu C, Li X, Shi Y, Luo L, Du Y, You J
Nanoscale 2020 Sep 21;12(35):18249-18262
Nanoscale 2020 Sep 21;12(35):18249-18262
MicroRNA-128-1-5p attenuates myocardial ischemia/reperfusion injury by suppressing Gadd45g-mediated apoptotic signaling.
Wan X, Yao B, Ma Y, Liu Y, Tang Y, Hu J, Li M, Fu S, Zheng X, Yin D
Biochemical and biophysical research communications 2020 Sep 10;530(1):314-321
Biochemical and biophysical research communications 2020 Sep 10;530(1):314-321
The effect and mechanism of 19S proteasome PSMD11/Rpn6 subunit in D-Galactose induced mimetic aging models.
Wu H, Sun H, He Z, Chen X, Li Y, Zhao X, Kong W, Kong W
Experimental cell research 2020 Sep 1;394(1):112093
Experimental cell research 2020 Sep 1;394(1):112093
The AKT/GSK3-Mediated Slug Expression Contributes to Oxaliplatin Resistance in Colorectal Cancer via Upregulation of ERCC1.
Wei W, Ma XD, Jiang GM, Shi B, Zhong W, Sun CL, Zhao L, Hou YJ, Wang H
Oncology research 2020 Sep 1;28(4):423-438
Oncology research 2020 Sep 1;28(4):423-438
Bovine Milk Exosomes Affect Proliferation and Protect Macrophages against Cisplatin-Induced Cytotoxicity.
Matic S, D'Souza DH, Wu T, Pangloli P, Dia VP
Immunological investigations 2020 Oct;49(7):711-725
Immunological investigations 2020 Oct;49(7):711-725
3-Acetyldeoxynivalenol induces lysosomal membrane permeabilization-mediated apoptosis and inhibits autophagic flux in macrophages.
Liu N, Yang Y, Chen J, Jia H, Zhang Y, Jiang D, Wu G, Wu Z
Environmental pollution (Barking, Essex : 1987) 2020 Oct;265(Pt B):114697
Environmental pollution (Barking, Essex : 1987) 2020 Oct;265(Pt B):114697
mTOR-autophagy promotes pulmonary senescence through IMP1 in chronic toxicity of methamphetamine.
Zhu MJ, Liu BY, Shi L, Wang X, Wang Y
Journal of cellular and molecular medicine 2020 Oct;24(20):12082-12093
Journal of cellular and molecular medicine 2020 Oct;24(20):12082-12093
Involvement of p53 Acetylation in Growth Suppression of Cutaneous T-Cell Lymphomas Induced by HDAC Inhibition.
Yu X, Li H, Zhu M, Hu P, Liu X, Qing Y, Wang X, Wang H, Wang Z, Xu J, Tan R, Guo Q, Hui H
The Journal of investigative dermatology 2020 Oct;140(10):2009-2022.e4
The Journal of investigative dermatology 2020 Oct;140(10):2009-2022.e4
Huoxin pill attenuates myocardial infarction-induced apoptosis and fibrosis via suppression of p53 and TGF-β1/Smad2/3 pathways.
Shen Z, Shen A, Chen X, Wu X, Chu J, Cheng Y, Peng M, Chen Y, Weygant N, Wu M, Lin X, Peng J, Chen K
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Oct;130:110618
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Oct;130:110618
Identification of osalmid metabolic profile and active metabolites with anti-tumor activity in human hepatocellular carcinoma cells.
Wu Z, Zhan Y, Wang L, Tong J, Zhang L, Lin M, Jin X, Jiang L, Lou Y, Qiu Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Oct;130:110556
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Oct;130:110556
Paired like homeodomain 1 and SAM and SH3 domain-containing 1 in the progression and prognosis of head and neck squamous cell carcinoma.
Jin Y, Qin X
The international journal of biochemistry & cell biology 2020 Oct;127:105846
The international journal of biochemistry & cell biology 2020 Oct;127:105846
c-Myc inactivation of p53 through the pan-cancer lncRNA MILIP drives cancer pathogenesis.
Feng YC, Liu XY, Teng L, Ji Q, Wu Y, Li JM, Gao W, Zhang YY, La T, Tabatabaee H, Yan XG, Jamaluddin MFB, Zhang D, Guo ST, Scott RJ, Liu T, Thorne RF, Zhang XD, Jin L
Nature communications 2020 Oct 5;11(1):4980
Nature communications 2020 Oct 5;11(1):4980
A Dedicated Evolutionarily Conserved Molecular Network Licenses Differentiated Cells to Return to the Cell Cycle.
Miao ZF, Lewis MA, Cho CJ, Adkins-Threats M, Park D, Brown JW, Sun JX, Burclaff JR, Kennedy S, Lu J, Mahar M, Vietor I, Huber LA, Davidson NO, Cavalli V, Rubin DC, Wang ZN, Mills JC
Developmental cell 2020 Oct 26;55(2):178-194.e7
Developmental cell 2020 Oct 26;55(2):178-194.e7
Loss of RAD6B induces degeneration of the cochlea in mice.
Ma Y, Song Y, Shen R, Li P, Ding H, Guo Z, Liu X, Wang D
Biochemical and biophysical research communications 2020 Oct 20;531(3):402-408
Biochemical and biophysical research communications 2020 Oct 20;531(3):402-408
NO66 overexpression rescues ethanol-induced cell apoptosis in human AC16 cardiomyocytes by suppressing PTEN and activating the PI3K/Akt signaling.
Deng H, Yu B, Yu Y, Tian G, Yang L
Acta biochimica et biophysica Sinica 2020 Oct 19;52(10):1093-1101
Acta biochimica et biophysica Sinica 2020 Oct 19;52(10):1093-1101
Metformin promotes the osseointegration of titanium implants under osteoporotic conditions by regulating BMSCs autophagy, and osteogenic differentiation.
Lin J, Xu R, Shen X, Jiang H, Du S
Biochemical and biophysical research communications 2020 Oct 15;531(2):228-235
Biochemical and biophysical research communications 2020 Oct 15;531(2):228-235
Lamin B1 deficiency promotes malignancy and predicts poor prognosis in gastric cancer.
Yu ZY, Jiang XY, Zhao RR, Luo CJ, Ren YX, Ma ZJ, Ye HL, Shi WG, Wang C, Jiao ZY
Neoplasma 2020 Nov;67(6):1303-1313
Neoplasma 2020 Nov;67(6):1303-1313
miR-5193, regulated by FUT1, suppresses proliferation and migration of ovarian cancer cells by targeting TRIM11.
Song Z, Guo Q, Wang H, Gao L, Wang S, Liu D, Liu J, Qi Y, Lin B
Pathology, research and practice 2020 Nov;216(11):153148
Pathology, research and practice 2020 Nov;216(11):153148
Functionalized graphene oxide against U251 glioma cells and its molecular mechanism.
Wang P, Wang X, Tang Q, Chen H, Zhang Q, Jiang H, Wang Z
Materials science & engineering. C, Materials for biological applications 2020 Nov;116:111187
Materials science & engineering. C, Materials for biological applications 2020 Nov;116:111187
Comparison of the Effects of Nonprotein and Protein Nitrogen on Apoptosis and Autophagy of Rumen Epithelial Cells in Goats.
Kong Z, Zhou C, Kang J, Tan Z
Animals : an open access journal from MDPI 2020 Nov 9;10(11)
Animals : an open access journal from MDPI 2020 Nov 9;10(11)
Design and synthesis of novel Flavone-based histone deacetylase inhibitors antagonizing activation of STAT3 in breast cancer.
Wei M, Xie M, Zhang Z, Wei Y, Zhang J, Pan H, Li B, Wang J, Song Y, Chong C, Zhao R, Wang J, Yu L, Yang G, Yang C
European journal of medicinal chemistry 2020 Nov 15;206:112677
European journal of medicinal chemistry 2020 Nov 15;206:112677
Upregulation of mitochondrial E3 ubiquitin ligase 1 in rat heart contributes to ischemia/reperfusion injury.
Wang SJ, Chen H, Tang LJ, Tu H, Liu B, Li NS, Luo XJ, Peng J
Canadian journal of physiology and pharmacology 2020 May;98(5):259-266
Canadian journal of physiology and pharmacology 2020 May;98(5):259-266
ADAM12 silencing promotes cellular apoptosis by activating autophagy in choriocarcinoma cells.
Wang L, Tan Z, Zhang Y, Kady Keita N, Liu H, Zhang Y
International journal of oncology 2020 May;56(5):1162-1174
International journal of oncology 2020 May;56(5):1162-1174
Exogenous spermine attenuates rat diabetic cardiomyopathy via suppressing ROS-p53 mediated downregulation of calcium-sensitive receptor.
Wang Y, Chen J, Li S, Zhang X, Guo Z, Hu J, Shao X, Song N, Zhao Y, Li H, Yang G, Xu C, Wei C
Redox biology 2020 May;32:101514
Redox biology 2020 May;32:101514
Palmatine induces G2/M phase arrest and mitochondrial-associated pathway apoptosis in colon cancer cells by targeting AURKA.
Liu X, Zhang Y, Wu S, Xu M, Shen Y, Yu M, Fan J, Wei S, Xu C, Huang L, Zhao H, Li X, Ye X
Biochemical pharmacology 2020 May;175:113933
Biochemical pharmacology 2020 May;175:113933
Naked mole-rat very-high-molecular-mass hyaluronan exhibits superior cytoprotective properties.
Takasugi M, Firsanov D, Tombline G, Ning H, Ablaeva J, Seluanov A, Gorbunova V
Nature communications 2020 May 12;11(1):2376
Nature communications 2020 May 12;11(1):2376
Dietary supplementation of l-arginine and N-carbamylglutamate enhances duodenal barrier and mitochondrial functions and suppresses duodenal inflammation and mitophagy in suckling lambs suffering from intrauterine-growth-restriction.
Zhang H, Ma Y, Wang M, Elsabagh M, Loor JJ, Wang H
Food & function 2020 May 1;11(5):4456-4470
Food & function 2020 May 1;11(5):4456-4470
ROS/p53/miR‑335‑5p/Sp1 axis modulates the migration and epithelial to mesenchymal transition of JEG‑3 cells.
Lu W, Ma YY, Shao QQ, Liang J, Qi TT, Huang Y, Wang QJ
Molecular medicine reports 2020 Mar;21(3):1208-1216
Molecular medicine reports 2020 Mar;21(3):1208-1216
Ubiquitination of P53 by E3 ligase MKRN2 promotes melanoma cell proliferation.
Zhang Y, Cui N, Zheng G
Oncology letters 2020 Mar;19(3):1975-1984
Oncology letters 2020 Mar;19(3):1975-1984
BRD4 inhibition exerts anti-viral activity through DNA damage-dependent innate immune responses.
Wang J, Li GL, Ming SL, Wang CF, Shi LJ, Su BQ, Wu HT, Zeng L, Han YQ, Liu ZH, Jiang DW, Du YK, Li XD, Zhang GP, Yang GY, Chu BB
PLoS pathogens 2020 Mar;16(3):e1008429
PLoS pathogens 2020 Mar;16(3):e1008429
Multiple inflammatory profiles of microglia and altered neuroimages in APP/PS1 transgenic AD mice.
Liu L, Liu Y, Li N, Huang R, Zheng X, Huang L, Hou S, Yuan Q
Brain research bulletin 2020 Mar;156:86-104
Brain research bulletin 2020 Mar;156:86-104
G protein-coupled receptor kinase-2: A potential biomarker for early diabetic cardiomyopathy.
Lai S, Fu X, Yang S, Zhang S, Lin Q, Zhang M, Chen H
Journal of diabetes 2020 Mar;12(3):247-258
Journal of diabetes 2020 Mar;12(3):247-258
Novel HSP90-PI3K Dual Inhibitor Suppresses Melanoma Cell Proliferation by Interfering with HSP90-EGFR Interaction and Downstream Signaling Pathways.
Zhao Q, Zhu HP, Xie X, Mao Q, Liu YQ, He XH, Peng C, Jiang QL, Huang W
International journal of molecular sciences 2020 Mar 7;21(5)
International journal of molecular sciences 2020 Mar 7;21(5)
Association of the Polymorphism rs13259960 in SLEAR With Predisposition to Systemic Lupus Erythematosus.
Fan Z, Chen X, Liu L, Zhu C, Xu J, Yin X, Sheng Y, Zhu Z, Wen L, Zuo X, Zheng X, Zhang Y, Xu J, Huang H, Zhou F, Sun L, Luo J, Zhang D, Chen X, Cui Y, Hao Y, Cui Y, Zhang X, Chen R
Arthritis & rheumatology (Hoboken, N.J.) 2020 Jun;72(6):985-996
Arthritis & rheumatology (Hoboken, N.J.) 2020 Jun;72(6):985-996
Triptolide interrupts rRNA synthesis and induces the RPL23‑MDM2‑p53 pathway to repress lung cancer cells.
Wang J, Zhang ZQ, Li FQ, Chen JN, Gong X, Cao BB, Wang W
Oncology reports 2020 Jun;43(6):1863-1874
Oncology reports 2020 Jun;43(6):1863-1874
All-trans retinoic acid enhances the effect of Fra-1 to inhibit cell proliferation and metabolism in cervical cancer.
Dou Y, Huang D, Zeng X, Zhou Y, Jiang X, Yue C, He J, Xiao S
Biotechnology letters 2020 Jun;42(6):1051-1060
Biotechnology letters 2020 Jun;42(6):1051-1060
In vitro and in vivo growth inhibition of human cervical cancer cells via human papillomavirus E6/E7 mRNAs' cleavage by CRISPR/Cas13a system.
Chen Y, Jiang H, Wang T, He D, Tian R, Cui Z, Tian X, Gao Q, Ma X, Yang J, Wu J, Tan S, Xu H, Tang X, Wang Y, Yu Z, Han H, Das BC, Severinov K, Hitzeroth II, Debata PR, Xu W, Fan W, Jin Z, Cao C, Yu M, Xie W, Huang Z, Hu Z, You Z
Antiviral research 2020 Jun;178:104794
Antiviral research 2020 Jun;178:104794
Oxidative stress induces monocyte-to-myofibroblast transdifferentiation through p38 in pancreatic ductal adenocarcinoma.
Huang X, He C, Hua X, Kan A, Mao Y, Sun S, Duan F, Wang J, Huang P, Li S
Clinical and translational medicine 2020 Jun;10(2):e41
Clinical and translational medicine 2020 Jun;10(2):e41
Radiation-Induced DNMT3B Promotes Radioresistance in Nasopharyngeal Carcinoma through Methylation of p53 and p21.
Wu C, Guo E, Ming J, Sun W, Nie X, Sun L, Peng S, Luo M, Liu D, Zhang L, Mei Q, Long G, Hu G, Hu G
Molecular therapy oncolytics 2020 Jun 26;17:306-319
Molecular therapy oncolytics 2020 Jun 26;17:306-319
Neurotoxicity of aluminum oxide nanoparticles and their mechanistic role in dopaminergic neuron injury involving p53-related pathways.
Liu H, Zhang W, Fang Y, Yang H, Tian L, Li K, Lai W, Bian L, Lin B, Liu X, Xi Z
Journal of hazardous materials 2020 Jun 15;392:122312
Journal of hazardous materials 2020 Jun 15;392:122312
MeCP2 facilitates breast cancer growth via promoting ubiquitination-mediated P53 degradation by inhibiting RPL5/RPL11 transcription.
Tong D, Zhang J, Wang X, Li Q, Liu LY, Yang J, Guo B, Ni L, Zhao L, Huang C
Oncogenesis 2020 Jun 1;9(5):56
Oncogenesis 2020 Jun 1;9(5):56
10-Hydroxydecanoic acid inhibits LPS-induced inflammation by targeting p53 in microglial cells.
You M, Miao Z, Sienkiewicz O, Jiang X, Zhao X, Hu F
International immunopharmacology 2020 Jul;84:106501
International immunopharmacology 2020 Jul;84:106501
Downregulation of circular RNA circPVT1 restricts cell growth of hepatocellular carcinoma through downregulation of Sirtuin 7 via microRNA-3666.
Li Y, Shi H, Yuan J, Qiao L, Dong L, Wang Y
Clinical and experimental pharmacology & physiology 2020 Jul;47(7):1291-1300
Clinical and experimental pharmacology & physiology 2020 Jul;47(7):1291-1300
Transcription factorIRX5 promotes hepatocellular carcinoma proliferation and inhibits apoptosis by regulating the p53 signalling pathway.
Zhu L, Dai L, Yang N, Liu M, Ma S, Li C, Shen J, Lin T, Wang D, Pan W, Li X
Cell biochemistry and function 2020 Jul;38(5):621-629
Cell biochemistry and function 2020 Jul;38(5):621-629
Toosendanin-induced apoptosis in colorectal cancer cells is associated with the κ-opioid receptor/β-catenin signaling axis.
Wang H, Wen C, Chen S, Wang F, He L, Li W, Zhou Q, Yu WK, Huang L, Chen J, Liu R, Li W, Yang X, Liu H
Biochemical pharmacology 2020 Jul;177:114014
Biochemical pharmacology 2020 Jul;177:114014
Mutant p53 Drives Cancer Metastasis via RCP-Mediated Hsp90α Secretion.
Zhang S, Wang C, Ma B, Xu M, Xu S, Liu J, Tian Y, Fu Y, Luo Y
Cell reports 2020 Jul 7;32(1):107879
Cell reports 2020 Jul 7;32(1):107879
Pyroptosis and ferroptosis induced by mixed lineage kinase 3 (MLK3) signaling in cardiomyocytes are essential for myocardial fibrosis in response to pressure overload.
Wang J, Deng B, Liu Q, Huang Y, Chen W, Li J, Zhou Z, Zhang L, Liang B, He J, Chen Z, Yan C, Yang Z, Xian S, Wang L
Cell death & disease 2020 Jul 24;11(7):574
Cell death & disease 2020 Jul 24;11(7):574
Curcumin-enhanced antitumor effects of sorafenib via regulating the metabolism and tumor microenvironment.
Man S, Yao J, Lv P, Liu Y, Yang L, Ma L
Food & function 2020 Jul 22;11(7):6422-6432
Food & function 2020 Jul 22;11(7):6422-6432
The E3 ubiquitin ligase UBR5 interacts with the H/ACA ribonucleoprotein complex and regulates ribosomal RNA biogenesis in embryonic stem cells.
Saez I, Gerbracht JV, Koyuncu S, Lee HJ, Horn M, Kroef V, Denzel MS, Dieterich C, Gehring NH, Vilchez D
FEBS letters 2020 Jan;594(1):175-188
FEBS letters 2020 Jan;594(1):175-188
Pentamidine inhibits prostate cancer progression via selectively inducing mitochondrial DNA depletion and dysfunction.
Liu L, Wang F, Tong Y, Li LF, Liu Y, Gao WQ
Cell proliferation 2020 Jan;53(1):e12718
Cell proliferation 2020 Jan;53(1):e12718
Withaferin A triggers G2/M arrest and intrinsic apoptosis in glioblastoma cells via ATF4-ATF3-CHOP axis.
Tang Q, Ren L, Liu J, Li W, Zheng X, Wang J, Du G
Cell proliferation 2020 Jan;53(1):e12706
Cell proliferation 2020 Jan;53(1):e12706
Disulfiram/Copper Induces Antitumor Activity against Both Nasopharyngeal Cancer Cells and Cancer-Associated Fibroblasts through ROS/MAPK and Ferroptosis Pathways.
Li Y, Chen F, Chen J, Chan S, He Y, Liu W, Zhang G
Cancers 2020 Jan 6;12(1)
Cancers 2020 Jan 6;12(1)
Cooperation of SRPK2, Numb and p53 in the malignant biology and chemosensitivity of colorectal cancer.
Wang G, Sheng W, Tang J, Li X, Zhou J, Dong M
Bioscience reports 2020 Jan 31;40(1)
Bioscience reports 2020 Jan 31;40(1)
Inhibition of long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 attenuates high glucose-induced cardiomyocyte apoptosis via regulation of miR-181a-5p.
Cheng Y, Li J, Wang C, Yang H, Wang Y, Zhan T, Guo S, Liang J, Bai Y, Yu J, Liu G
Experimental animals 2020 Jan 29;69(1):34-44
Experimental animals 2020 Jan 29;69(1):34-44
Apoptotic Effect of 1800 MHz Electromagnetic Radiation on NIH/3T3 Cells.
Li DY, Song JD, Liang ZY, Oskouei K, Xiao XQ, Hou WZ, Li JT, Yang YS, Wang ML, Murbach M
International journal of environmental research and public health 2020 Jan 28;17(3)
International journal of environmental research and public health 2020 Jan 28;17(3)
Liver changes induced by cadmium poisoning distinguished by confocal Raman imaging.
Li Y, Shen R, Wu H, Yu L, Wang Z, Wang D
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 2020 Jan 15;225:117483
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 2020 Jan 15;225:117483
RETRACTED: Endogenous production of C-C motif chemokine ligand 2 by nasopharyngeal carcinoma cells drives radioresistance-associated metastasis.
Guo SS, Liu R, Wen YF, Liu LT, Yuan L, Li YX, Li Y, Hao WW, Peng JY, Chen DN, Tang QN, Sun XS, Guo L, Mo HY, Qian CN, Zeng MS, Bei JX, Sun SY, Chen QY, Tang LQ, Mai HQ
Cancer letters 2020 Jan 1;468:27-40
Cancer letters 2020 Jan 1;468:27-40
Novel, genetically induced mouse model that recapitulates the histological morphology and immunosuppressive tumor microenvironment of metastatic peritoneal carcinomatosis.
Tseng SH, Park ST, Lam B, Tsai YC, Cheng MA, Farmer E, Xing D, Hung CF
Journal for immunotherapy of cancer 2020 Feb;8(1)
Journal for immunotherapy of cancer 2020 Feb;8(1)
NAMPT maintains mitochondria content via NRF2-PPARα/AMPKα pathway to promote cell survival under oxidative stress.
Yu A, Zhou R, Xia B, Dang W, Yang Z, Chen X
Cellular signalling 2020 Feb;66:109496
Cellular signalling 2020 Feb;66:109496
Tumor suppressor LHPP regulates the proliferation of colorectal cancer cells via the PI3K/AKT pathway.
Hou B, Li W, Li J, Ma J, Xia P, Liu Z, Zeng Q, Zhang X, Chang D
Oncology reports 2020 Feb;43(2):536-548
Oncology reports 2020 Feb;43(2):536-548
GRWD1 promotes cell proliferation and migration in non-small cell lung cancer by activating the Notch pathway.
Wang Q, Ren H, Xu Y, Jiang J, Wudu M, Liu Z, Su H, Jiang X, Zhang Y, Zhang B, Qiu X
Experimental cell research 2020 Feb 15;387(2):111806
Experimental cell research 2020 Feb 15;387(2):111806
Disruption of the Keap1/Nrf2-Antioxidant Response System After Chronic Doxorubicin Exposure In Vivo.
Nordgren KKS, Wallace KB
Cardiovascular toxicology 2020 Dec;20(6):557-570
Cardiovascular toxicology 2020 Dec;20(6):557-570
High expression of RRM2 as an independent predictive factor of poor prognosis in patients with lung adenocarcinoma.
Jin CY, Du L, Nuerlan AH, Wang XL, Yang YW, Guo R
Aging 2020 Dec 19;13(3):3518-3535
Aging 2020 Dec 19;13(3):3518-3535
Inhibitor of growth 2 regulates the high glucose-induced cell cycle arrest and epithelial-to-mesenchymal transition in renal proximal tubular cells.
Ma Y, Yan R, Wan Q, Lv B, Yang Y, Lv T, Xin W
Journal of physiology and biochemistry 2020 Aug;76(3):373-382
Journal of physiology and biochemistry 2020 Aug;76(3):373-382
Exopolysaccharide from Cryptococcus heimaeyensis S20 induces autophagic cell death in non-small cell lung cancer cells via ROS/p38 and ROS/ERK signalling.
Hao Y, Huang Y, Chen J, Li J, Yuan Y, Wang M, Han L, Xin X, Wang H, Lin D, Peng F, Yu F, Zheng C, Shen C
Cell proliferation 2020 Aug;53(8):e12869
Cell proliferation 2020 Aug;53(8):e12869
TP53 mutation influences the efficacy of treatment of colorectal cancer cell lines with a combination of sirtuin inhibitors and chemotherapeutic agents.
Yang H, Chen Y, Jiang Y, Wang D, Yan J, Zhou Z
Experimental and therapeutic medicine 2020 Aug;20(2):1415-1422
Experimental and therapeutic medicine 2020 Aug;20(2):1415-1422
miR-106a Regulates Cell Proliferation and Autophagy by Targeting LKB1 in HPV-16-Associated Cervical Cancer.
Cui X, Wang X, Zhou X, Jia J, Chen H, Zhao W
Molecular cancer research : MCR 2020 Aug;18(8):1129-1141
Molecular cancer research : MCR 2020 Aug;18(8):1129-1141
Ginsenoside Rh4 suppresses aerobic glycolysis and the expression of PD-L1 via targeting AKT in esophageal cancer.
Deng X, Zhao J, Qu L, Duan Z, Fu R, Zhu C, Fan D
Biochemical pharmacology 2020 Aug;178:114038
Biochemical pharmacology 2020 Aug;178:114038
BCCIPβ facilitates p53 ubiquitination via binding with E6 protein in high-risk HPV positive head and neck squamous cell carcinoma.
Wang F, Wang J, Wang J, Zhang L, Fu H, Li J, Tian T, Zuo J, Lv W, Ma X
Biochemical and biophysical research communications 2020 Aug 27;529(3):685-691
Biochemical and biophysical research communications 2020 Aug 27;529(3):685-691
Caloric restriction alleviates aging-related fibrosis of kidney through downregulation of miR-21 in extracellular vesicles.
Liu JR, Cai GY, Ning YC, Wang JC, Lv Y, Guo YN, Fu B, Hong Q, Sun XF, Chen XM
Aging 2020 Aug 27;12(18):18052-18072
Aging 2020 Aug 27;12(18):18052-18072
Synergistic effects of tanshinone IIA and andrographolide on the apoptosis of cancer cells via crosstalk between p53 and reactive oxygen species pathways.
Li Y, Jiang B, Wang R, Wang J, Li Y, Bao Y
Pharmacological reports : PR 2020 Apr;72(2):400-417
Pharmacological reports : PR 2020 Apr;72(2):400-417
COX-2/sEH dual inhibitor PTUPB alleviates bleomycin-induced pulmonary fibrosis in mice via inhibiting senescence.
Zhang CY, Duan JX, Yang HH, Sun CC, Zhong WJ, Tao JH, Guan XX, Jiang HL, Hammock BD, Hwang SH, Zhou Y, Guan CX
The FEBS journal 2020 Apr;287(8):1666-1680
The FEBS journal 2020 Apr;287(8):1666-1680
N(6)-methyladenosine mediates arsenite-induced human keratinocyte transformation by suppressing p53 activation.
Zhao T, Sun D, Zhao M, Lai Y, Liu Y, Zhang Z
Environmental pollution (Barking, Essex : 1987) 2020 Apr;259:113908
Environmental pollution (Barking, Essex : 1987) 2020 Apr;259:113908
Effects of selenium on the proliferation and apoptosis of sheep spermatogonial stem cells in vitro.
Shi L, Duan Y, Yao X, Song R, Ren Y
Animal reproduction science 2020 Apr;215:106330
Animal reproduction science 2020 Apr;215:106330
Cyanidin-3-O-glucoside restores spermatogenic dysfunction in cadmium-exposed pubertal mice via histone ubiquitination and mitigating oxidative damage.
Li X, Yao Z, Yang D, Jiang X, Sun J, Tian L, Hu J, Wu B, Bai W
Journal of hazardous materials 2020 Apr 5;387:121706
Journal of hazardous materials 2020 Apr 5;387:121706
A bicyclic pentapeptide-based highly potent and selective pan-SIRT1/2/3 inhibitor harboring N(ε)-thioacetyl-lysine.
Li R, Yan L, Sun X, Zheng W
Bioorganic & medicinal chemistry 2020 Apr 1;28(7):115356
Bioorganic & medicinal chemistry 2020 Apr 1;28(7):115356
MicroRNA-16 participates in the cell cycle alteration of HepG2 cells induced by MC-LR.
Feng Y, Chen X, Ding W, Ma J, Zhang B, Li X
Ecotoxicology and environmental safety 2020 Apr 1;192:110295
Ecotoxicology and environmental safety 2020 Apr 1;192:110295
Genome-scale CRISPR activation screening identifies a role of ELAVL2-CDKN1A axis in paclitaxel resistance in esophageal squamous cell carcinoma.
Zhao WS, Yan WP, Chen DB, Dai L, Yang YB, Kang XZ, Fu H, Chen P, Deng KJ, Wang XY, Xie XW, Chen HS, Chen KN
American journal of cancer research 2019;9(6):1183-1200
American journal of cancer research 2019;9(6):1183-1200
Hypoxia-induced feedback of HIF-1α and lncRNA-CF129 contributes to pancreatic cancer progression through stabilization of p53 protein.
Liu M, Zhong J, Zeng Z, Huang K, Ye Z, Deng S, Chen H, Xu F, Li Q, Zhao G
Theranostics 2019;9(16):4795-4810
Theranostics 2019;9(16):4795-4810
Novel Breast-Specific Long Non-coding RNA LINC00993 Acts as a Tumor Suppressor in Triple-Negative Breast Cancer.
Guo S, Jian L, Tao K, Chen C, Yu H, Liu S
Frontiers in oncology 2019;9:1325
Frontiers in oncology 2019;9:1325
Long Non-coding RNA SNHG12 Functions as a Competing Endogenous RNA to Regulate MDM4 Expression by Sponging miR-129-5p in Clear Cell Renal Cell Carcinoma.
Wu Z, Chen D, Wang K, Cao C, Xu X
Frontiers in oncology 2019;9:1260
Frontiers in oncology 2019;9:1260
miR-4521-FAM129A axial regulation on ccRCC progression through TIMP-1/MMP2/MMP9 and MDM2/p53/Bcl2/Bax pathways.
Feng X, Yan N, Sun W, Zheng S, Jiang S, Wang J, Guo C, Hao L, Tian Y, Liu S, Sun MZ
Cell death discovery 2019;5:89
Cell death discovery 2019;5:89
LncRNA ZFAS1 promotes proliferation and migration and inhibits apoptosis in nasopharyngeal carcinoma via the PI3K/AKT pathway in vitro.
Wang X, Jin Q, Wang X, Chen W, Cai Z
Cancer biomarkers : section A of Disease markers 2019;26(2):171-182
Cancer biomarkers : section A of Disease markers 2019;26(2):171-182
2-Methoxy-5((3,4,5-trimethosyphenyl)seleninyl) phenol reverses EGF-induced cell migration and invasion through down-regulation of MDM2 in breast cancer cell lines.
Zheng D, Chang X, Liu Y, Xu J, Gou W, Li Z, Zuo D, Zhang W, Wu Y
Cancer biology & therapy 2019;20(4):513-523
Cancer biology & therapy 2019;20(4):513-523
MDM2 inhibitor RG7388 potently inhibits tumors by activating p53 pathway in nasopharyngeal carcinoma.
Fan X, Wang Y, Song J, Wu H, Yang M, Lu L, Weng X, Liu L, Nie G
Cancer biology & therapy 2019;20(10):1328-1336
Cancer biology & therapy 2019;20(10):1328-1336
SSRP1 influences colorectal cancer cell growth and apoptosis via the AKT pathway.
Wang Q, Jia S, Jiao Y, Xu L, Wang D, Chen X, Hu X, Liang H, Wen N, Zhang S, Guo B, Zhang L
International journal of medical sciences 2019;16(12):1573-1582
International journal of medical sciences 2019;16(12):1573-1582
The ginsenoside Rk3 exerts anti-esophageal cancer activity in vitro and in vivo by mediating apoptosis and autophagy through regulation of the PI3K/Akt/mTOR pathway.
Liu H, Zhao J, Fu R, Zhu C, Fan D
PloS one 2019;14(5):e0216759
PloS one 2019;14(5):e0216759
Synergism of cisplatin-oleanolic acid co-loaded calcium carbonate nanoparticles on hepatocellular carcinoma cells for enhanced apoptosis and reduced hepatotoxicity.
Khan MW, Zhao P, Khan A, Raza F, Raza SM, Sarfraz M, Chen Y, Li M, Yang T, Ma X, Xiang G
International journal of nanomedicine 2019;14:3753-3771
International journal of nanomedicine 2019;14:3753-3771
RAD6B Plays a Critical Role in Neuronal DNA Damage Response to Resist Neurodegeneration.
Guo Z, Tian Y, Guo Y, Li B, Liu X, Xie K, Song Y, Wang D
Frontiers in cellular neuroscience 2019;13:392
Frontiers in cellular neuroscience 2019;13:392
Hypermethylation Of ADHFE1 Promotes The Proliferation Of Colorectal Cancer Cell Via Modulating Cell Cycle Progression.
Hu YH, Ma S, Zhang XN, Zhang ZY, Zhu HF, Ji YH, Li J, Qian XL, Wang YX
OncoTargets and therapy 2019;12:8105-8115
OncoTargets and therapy 2019;12:8105-8115
SIRT6 promotes the Warburg effect of papillary thyroid cancer cell BCPAP through reactive oxygen species.
Yu W, Yang Z, Huang R, Min Z, Ye M
OncoTargets and therapy 2019;12:2861-2868
OncoTargets and therapy 2019;12:2861-2868
6-Bromoindirubin-3'-Oxime (6BIO) Suppresses the mTOR Pathway, Promotes Autophagy, and Exerts Anti-aging Effects in Rodent Liver.
Guo D, Shen Y, Li W, Li Q, Zhao Y, Pan C, Chen B, Zhong Y, Miao Y
Frontiers in pharmacology 2019;10:320
Frontiers in pharmacology 2019;10:320
Ubiquitination of the HPV Oncoprotein E6 Is Critical for E6/E6AP-Mediated p53 Degradation.
Li S, Hong X, Wei Z, Xie M, Li W, Liu G, Guo H, Yang J, Wei W, Zhang S
Frontiers in microbiology 2019;10:2483
Frontiers in microbiology 2019;10:2483
Protective Effects of Dioscin Against Doxorubicin-Induced Hepatotoxicity Via Regulation of Sirt1/FOXO1/NF-κb Signal.
Song S, Chu L, Liang H, Chen J, Liang J, Huang Z, Zhang B, Chen X
Frontiers in pharmacology 2019;10:1030
Frontiers in pharmacology 2019;10:1030
Hydrogen inhalation protects hypoxic-ischemic brain damage by attenuating inflammation and apoptosis in neonatal rats.
Wu G, Chen Z, Wang P, Zhao M, Fujino M, Zhang C, Zhou W, Hirano SI, Li XK, Zhao L
Experimental biology and medicine (Maywood, N.J.) 2019 Sep;244(12):1017-1027
Experimental biology and medicine (Maywood, N.J.) 2019 Sep;244(12):1017-1027
Functional daidzein enhances the anticancer effect of topotecan and reverses BCRP-mediated drug resistance in breast cancer.
Guo J, Wang Q, Zhang Y, Sun W, Zhang S, Li Y, Wang J, Bao Y
Pharmacological research 2019 Sep;147:104387
Pharmacological research 2019 Sep;147:104387
Parthenolide regulates oxidative stress-induced mitophagy and suppresses apoptosis through p53 signaling pathway in C2C12 myoblasts.
Ren Y, Li Y, Lv J, Guo X, Zhang J, Zhou D, Zhang Z, Xue Z, Yang G, Xi Q, Liu H, Liu Z, Zhang L, Zhang Q, Yao Z, Zhang R, Da Y
Journal of cellular biochemistry 2019 Sep;120(9):15695-15708
Journal of cellular biochemistry 2019 Sep;120(9):15695-15708
XAB2 depletion induces intron retention in POLR2A to impair global transcription and promote cellular senescence.
Hou S, Qu D, Li Y, Zhu B, Liang D, Wei X, Tang W, Zhang Q, Hao J, Guo W, Wang W, Zhao S, Wang Q, Azam S, Khan M, Zhao H, Zhang L, Lei H
Nucleic acids research 2019 Sep 5;47(15):8239-8254
Nucleic acids research 2019 Sep 5;47(15):8239-8254
Partially Hydrolyzed Guar Gum Attenuates d-Galactose-Induced Oxidative Stress and Restores Gut Microbiota in Rats.
Liu X, Wu C, Han D, Liu J, Liu H, Jiang Z
International journal of molecular sciences 2019 Sep 30;20(19)
International journal of molecular sciences 2019 Sep 30;20(19)
Long non-coding RNA HOTAIR modulates intervertebral disc degenerative changes via Wnt/β-catenin pathway.
Zhan S, Wang K, Song Y, Li S, Yin H, Luo R, Liao Z, Wu X, Zhang Y, Yang C
Arthritis research & therapy 2019 Sep 3;21(1):201
Arthritis research & therapy 2019 Sep 3;21(1):201
RNA-binding protein CELF6 is cell cycle regulated and controls cancer cell proliferation by stabilizing p21.
Liu G, Zhang Q, Xia L, Shi M, Cai J, Zhang H, Li J, Lin G, Xie W, Zhang Y, Xu N
Cell death & disease 2019 Sep 18;10(10):688
Cell death & disease 2019 Sep 18;10(10):688
Design, synthesis, antitumor activities and biological studies of novel diaryl substituted fused heterocycles as dual ligands targeting tubulin and katanin.
Gao F, Liang Y, Zhou P, Cheng J, Ding K, Wang Y
European journal of medicinal chemistry 2019 Sep 15;178:177-194
European journal of medicinal chemistry 2019 Sep 15;178:177-194
miR-146a attenuates apoptosis and modulates autophagy by targeting TAF9b/P53 pathway in doxorubicin-induced cardiotoxicity.
Pan JA, Tang Y, Yu JY, Zhang H, Zhang JF, Wang CQ, Gu J
Cell death & disease 2019 Sep 11;10(9):668
Cell death & disease 2019 Sep 11;10(9):668
Dexmedetomidine protects hippocampal neurons against hypoxia/reoxygenation-induced apoptosis through activation HIF-1α/p53 signaling.
Gao Y, Yin H, Zhang Y, Dong Y, Yang F, Wu X, Liu H
Life sciences 2019 Sep 1;232:116611
Life sciences 2019 Sep 1;232:116611
Rice protein reduces DNA damage by activating the p53 pathway and stimulating endogenous antioxidant response in growing and adult rats.
Liang M, Li H, Wang Z, Cai L, Yang L
Journal of the science of food and agriculture 2019 Oct;99(13):6097-6107
Journal of the science of food and agriculture 2019 Oct;99(13):6097-6107
Knockdown of RNF2 enhances the radiosensitivity of squamous cell carcinoma in lung.
Yang J, Yu F, Guan J, Wang T, Liu C, Wang Y, Liu G, Zhu S
Biochemistry and cell biology = Biochimie et biologie cellulaire 2019 Oct;97(5):589-599
Biochemistry and cell biology = Biochimie et biologie cellulaire 2019 Oct;97(5):589-599
Cyclin-dependent kinase 1 disruption inhibits angiogenesis by inducing cell cycle arrest and apoptosis.
Gao X, Zhang Y, Zhang R, Zhao Z, Zhang H, Wu J, Shen W, Zhong M
Experimental and therapeutic medicine 2019 Oct;18(4):3062-3070
Experimental and therapeutic medicine 2019 Oct;18(4):3062-3070
Semaphorin 4C Promotes Macrophage Recruitment and Angiogenesis in Breast Cancer.
Yang J, Zeng Z, Qiao L, Jiang X, Ma J, Wang J, Ye S, Ma Q, Wei J, Wu M, Huang X, Ma D, Gao Q
Molecular cancer research : MCR 2019 Oct;17(10):2015-2028
Molecular cancer research : MCR 2019 Oct;17(10):2015-2028
RNA sequencing analysis of the CAL-27 cell response to over-expressed ZNF750 gene revealed an extensive regulation on cell cycle.
Liu X, Yang Y, Xu C, Yang H, Chen S, Chen H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109377
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109377
Anti-ageing and antioxidant effects of sulfate oligosaccharides from green algae Ulva lactuca and Enteromorpha prolifera in SAMP8 mice.
Liu XY, Liu D, Lin GP, Wu YJ, Gao LY, Ai C, Huang YF, Wang MF, El-Seedi HR, Chen XH, Zhao C
International journal of biological macromolecules 2019 Oct 15;139:342-351
International journal of biological macromolecules 2019 Oct 15;139:342-351
NEDD4 protects vascular endothelial cells against Angiotensin II-induced cell death via enhancement of XPO1-mediated nuclear export.
Xu J, Sheng Z, Li F, Wang S, Yuan Y, Wang M, Yu Z
Experimental cell research 2019 Oct 1;383(1):111505
Experimental cell research 2019 Oct 1;383(1):111505
Dehydrogenase/reductase SDR family member 2 silencing sensitizes an oxaliplatin‑resistant cell line to oxaliplatin by inhibiting excision repair cross‑complementing group 1 protein expression.
Li JM, Jiang GM, Zhao L, Yang F, Yuan WQ, Wang H, Luo YQ
Oncology reports 2019 Nov;42(5):1725-1734
Oncology reports 2019 Nov;42(5):1725-1734
Niban protein regulates apoptosis in HK-2 cells via caspase-dependent pathway.
Tang S, Wang J, Liu J, Huang Y, Zhou Y, Yang S, Zhang W, Yang M, Zhang H
Renal failure 2019 Nov;41(1):455-466
Renal failure 2019 Nov;41(1):455-466
Sulforaphane Mediates Glutathione Depletion via Polymeric Nanoparticles to Restore Cisplatin Chemosensitivity.
Xu Y, Han X, Li Y, Min H, Zhao X, Zhang Y, Qi Y, Shi J, Qi S, Bao Y, Nie G
ACS nano 2019 Nov 26;13(11):13445-13455
ACS nano 2019 Nov 26;13(11):13445-13455
Folic acid delays age-related cognitive decline in senescence-accelerated mouse prone 8: alleviating telomere attrition as a potential mechanism.
Lv X, Wang X, Wang Y, Zhou D, Li W, Wilson JX, Chang H, Huang G
Aging 2019 Nov 22;11(22):10356-10373
Aging 2019 Nov 22;11(22):10356-10373
CD105 Is Expressed in Ovarian Cancer Precursor Lesions and Is Required for Metastasis to the Ovary.
Bai S, Zhu W, Coffman L, Vlad A, Schwartz LE, Elishaev E, Drapkin R, Buckanovich RJ
Cancers 2019 Nov 2;11(11)
Cancers 2019 Nov 2;11(11)
Serine/arginine protein-specific kinase 2 promotes the development and progression of pancreatic cancer by downregulating Numb and p53.
Wang G, Sheng W, Shi X, Li X, Zhou J, Dong M
The FEBS journal 2019 May;286(9):1668-1682
The FEBS journal 2019 May;286(9):1668-1682
Establishment and characterization of a radiation-induced dermatitis rat model.
Sheng X, Zhou Y, Wang H, Shen Y, Liao Q, Rao Z, Deng F, Xie L, Yao C, Mao H, Liu Z, Peng M, Long Y, Zeng Y, Xue L, Gao N, Kong Y, Zhou X
Journal of cellular and molecular medicine 2019 May;23(5):3178-3189
Journal of cellular and molecular medicine 2019 May;23(5):3178-3189
Fuplatin: An Efficient and Low-Toxic Dual-Prodrug.
Zhang R, Song XQ, Liu RP, Ma ZY, Xu JY
Journal of medicinal chemistry 2019 May 9;62(9):4543-4554
Journal of medicinal chemistry 2019 May 9;62(9):4543-4554
miR-340-FHL2 axis inhibits cell growth and metastasis in ovarian cancer.
Huang Z, Li Q, Luo K, Zhang Q, Geng J, Zhou X, Xu Y, Qian M, Zhang JA, Ji L, Wu J
Cell death & disease 2019 May 8;10(5):372
Cell death & disease 2019 May 8;10(5):372
Cloxiquine, a traditional antituberculosis agent, suppresses the growth and metastasis of melanoma cells through activation of PPARγ.
Zhang W, Shao W, Dong Z, Zhang S, Liu C, Chen S
Cell death & disease 2019 May 28;10(6):404
Cell death & disease 2019 May 28;10(6):404
CircRNA_014511 affects the radiosensitivity of bone marrow mesenchymal stem cells by binding to miR-29b-2-5p.
Wang Y, Zhang J, Li J, Gui R, Nie X, Huang R
Bosnian journal of basic medical sciences 2019 May 20;19(2):155-163
Bosnian journal of basic medical sciences 2019 May 20;19(2):155-163
Retinoic Acid-Related Orphan Receptor C Regulates Proliferation, Glycolysis, and Chemoresistance via the PD-L1/ITGB6/STAT3 Signaling Axis in Bladder Cancer.
Cao D, Qi Z, Pang Y, Li H, Xie H, Wu J, Huang Y, Zhu Y, Shen Y, Zhu Y, Dai B, Hu X, Ye D, Wang Z
Cancer research 2019 May 15;79(10):2604-2618
Cancer research 2019 May 15;79(10):2604-2618
Avenanthramide A Induces Cellular Senescence via miR-129-3p/Pirh2/p53 Signaling Pathway To Suppress Colon Cancer Growth.
Fu R, Yang P, Sajid A, Li Z
Journal of agricultural and food chemistry 2019 May 1;67(17):4808-4816
Journal of agricultural and food chemistry 2019 May 1;67(17):4808-4816
Anterior Gradient-2 monoclonal antibody inhibits lung cancer growth and metastasis by upregulating p53 pathway and without exerting any toxicological effects: A preclinical study.
Negi H, Merugu SB, Mangukiya HB, Li Z, Zhou B, Sehar Q, Kamle S, Yunus FU, Mashausi DS, Wu Z, Li D
Cancer letters 2019 May 1;449:125-134
Cancer letters 2019 May 1;449:125-134
p53/Lactate dehydrogenase A axis negatively regulates aerobic glycolysis and tumor progression in breast cancer expressing wild-type p53.
Zhou Y, Niu W, Luo Y, Li H, Xie Y, Wang H, Liu Y, Fan S, Li Z, Xiong W, Li X, Ren C, Tan M, Li G, Zhou M
Cancer science 2019 Mar;110(3):939-949
Cancer science 2019 Mar;110(3):939-949
TZAP plays an inhibitory role in the self-renewal of porcine mesenchymal stromal cells and is implicated the regulation of premature senescence via the p53 pathway.
Bie YN, Gu P, Chen YT, Zhou XX, Tian YG, Yang Q, Li HY, Lin X, Guan YH, Lin TY, Lu X, Shen HF, Fang TX, Liu YM, Xiao D, Gu WW
Journal of translational medicine 2019 Mar 7;17(1):72
Journal of translational medicine 2019 Mar 7;17(1):72
SIRT1 suppresses p53-dependent apoptosis by modulation of p21 in osteoblast-like MC3T3-E1 cells exposed to fluoride.
Gu X, Wang Z, Gao J, Han D, Zhang L, Chen P, Luo G, Han B
Toxicology in vitro : an international journal published in association with BIBRA 2019 Jun;57:28-38
Toxicology in vitro : an international journal published in association with BIBRA 2019 Jun;57:28-38
ERβ modulates genistein's cisplatin-enhancing activities in breast cancer MDA-MB-231 cells via P53-independent pathway.
Liu R, Xu X, Liang C, Chen X, Yu X, Zhong H, Xu W, Cheng Y, Wang W, Wu Y, Yu L, Hu X
Molecular and cellular biochemistry 2019 Jun;456(1-2):205-216
Molecular and cellular biochemistry 2019 Jun;456(1-2):205-216
The p53/miRNAs/Ccna2 pathway serves as a novel regulator of cellular senescence: Complement of the canonical p53/p21 pathway.
Xu S, Wu W, Huang H, Huang R, Xie L, Su A, Liu S, Zheng R, Yuan Y, Zheng HL, Sun X, Xiong XD, Liu X
Aging cell 2019 Jun;18(3):e12918
Aging cell 2019 Jun;18(3):e12918
Insulin-like growth factor-1 attenuates oxidative stress-induced hepatocyte premature senescence in liver fibrogenesis via regulating nuclear p53-progerin interaction.
Luo X, Jiang X, Li J, Bai Y, Li Z, Wei P, Sun S, Liang Y, Han S, Li X, Zhang B
Cell death & disease 2019 Jun 6;10(6):451
Cell death & disease 2019 Jun 6;10(6):451
RNF128 Promotes Invasion and Metastasis Via the EGFR/MAPK/MMP-2 Pathway in Esophageal Squamous Cell Carcinoma.
Gao J, Wang Y, Yang J, Zhang W, Meng K, Sun Y, Li Y, He QY
Cancers 2019 Jun 18;11(6)
Cancers 2019 Jun 18;11(6)
Dihydromyricetin alleviates acetaminophen-induced liver injury via the regulation of transformation, lipid homeostasis, cell death and regeneration.
Dong S, Ji J, Hu L, Wang H
Life sciences 2019 Jun 15;227:20-29
Life sciences 2019 Jun 15;227:20-29
2,4-Disubstituted quinazolines targeting breast cancer cells via EGFR-PI3K.
Li ED, Lin Q, Meng YQ, Zhang LY, Song PP, Li N, Xin JC, Yang P, Bao CN, Zhang DQ, Zhang Y, Wang JK, Zhang QR, Liu HM
European journal of medicinal chemistry 2019 Jun 15;172:36-47
European journal of medicinal chemistry 2019 Jun 15;172:36-47
Effects of palmatine hydrochloride mediated photodynamic therapy on oral squamous cell carcinoma.
Qi F, Sun Y, Lv M, Qin F, Cao W, Bi L
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2019 Jun 12;18(6):1596-1605
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 2019 Jun 12;18(6):1596-1605
Normoxia is not favorable for maintaining stemness of human endothelial progenitor cells.
Lin Y, Liu B, Deng T, Zhong J, Feng Z, Zeng Q, Huang G, Chen Z
Stem cell research 2019 Jul;38:101464
Stem cell research 2019 Jul;38:101464
NR2E3 is a key component in p53 activation by regulating a long noncoding RNA DINO in acute liver injuries.
Khanal T, Leung YK, Jiang W, Timchenko N, Ho SM, Kim K
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jul;33(7):8335-8348
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Jul;33(7):8335-8348
Methionine restriction delays senescence and suppresses the senescence-associated secretory phenotype in the kidney through endogenous hydrogen sulfide.
Wang SY, Wang WJ, Liu JQ, Song YH, Li P, Sun XF, Cai GY, Chen XM
Cell cycle (Georgetown, Tex.) 2019 Jul;18(14):1573-1587
Cell cycle (Georgetown, Tex.) 2019 Jul;18(14):1573-1587
Long non-coding RNA and mRNA profile analysis of metformin to reverse the pulmonary hypertension vascular remodeling induced by monocrotaline.
Sun Z, Liu Y, Yu F, Xu Y, Yanli L, Liu N
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jul;115:108933
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jul;115:108933
Regulatory factor X5 promotes hepatocellular carcinoma progression by transactivating tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta and suppressing apoptosis.
Chen DB, Zhao YJ, Wang XY, Liao WJ, Chen P, Deng KJ, Cong X, Fei R, Wu X, Shao QX, Wei L, Xie XW, Chen HS
Chinese medical journal 2019 Jul 5;132(13):1572-1581
Chinese medical journal 2019 Jul 5;132(13):1572-1581
Melatonin prevents lung injury by regulating apelin 13 to improve mitochondrial dysfunction.
Zhang L, Li F, Su X, Li Y, Wang Y, Fang R, Guo Y, Jin T, Shan H, Zhao X, Yang R, Shan H, Liang H
Experimental & molecular medicine 2019 Jul 4;51(7):1-12
Experimental & molecular medicine 2019 Jul 4;51(7):1-12
Discovery of N-phenyl-(2,4-dihydroxypyrimidine-5-sulfonamido) phenylurea-based thymidylate synthase (TS) inhibitor as a novel multi-effects antitumor drugs with minimal toxicity.
Li XY, Zhang TJ, Kamara MO, Lu GQ, Xu HL, Wang DP, Meng FH
Cell death & disease 2019 Jul 11;10(7):532
Cell death & disease 2019 Jul 11;10(7):532
ERp57‑small interfering RNA silencing can enhance the sensitivity of drug‑resistant human ovarian cancer cells to paclitaxel.
Li S, Zhao X, Chang S, Li Y, Guo M, Guan Y
International journal of oncology 2019 Jan;54(1):249-260
International journal of oncology 2019 Jan;54(1):249-260
Apoptosis induced by ursodeoxycholic acid in human melanoma cells through the mitochondrial pathway.
Yu H, Fu QR, Huang ZJ, Lin JY, Chen QX, Wang Q, Shen DY
Oncology reports 2019 Jan;41(1):213-223
Oncology reports 2019 Jan;41(1):213-223
Heme oxygenase-1 prevents heart against myocardial infarction by attenuating ischemic injury-induced cardiomyocytes senescence.
Shan H, Li T, Zhang L, Yang R, Li Y, Zhang M, Dong Y, Zhou Y, Xu C, Yang B, Liang H, Gao X, Shan H
EBioMedicine 2019 Jan;39:59-68
EBioMedicine 2019 Jan;39:59-68
Estrogen receptor variant ER-α36 promotes tamoxifen agonist activity in glioblastoma cells.
Qu C, Ma J, Zhang Y, Han C, Huang L, Shen L, Li H, Wang X, Liu J, Zou W
Cancer science 2019 Jan;110(1):221-234
Cancer science 2019 Jan;110(1):221-234
Intracellular NO-Generator Based on Enzyme Trigger for Localized Tumor-Cytoplasm Rapid Drug Release and Synergetic Cancer Therapy.
Hou L, Zhang Y, Yang X, Tian C, Yan Y, Zhang H, Shi J, Zhang H, Zhang Z
ACS applied materials & interfaces 2019 Jan 9;11(1):255-268
ACS applied materials & interfaces 2019 Jan 9;11(1):255-268
Genome-Wide Profiling of Cervical RNA-Binding Proteins Identifies Human Papillomavirus Regulation of RNASEH2A Expression by Viral E7 and E2F1.
Xu J, Liu H, Yang Y, Wang X, Liu P, Li Y, Meyers C, Banerjee NS, Wang HK, Cam M, Lu W, Chow LT, Xie X, Zhu J, Zheng ZM
mBio 2019 Jan 29;10(1)
mBio 2019 Jan 29;10(1)
A phenanthroline derivative enhances radiosensitivity of hepatocellular carcinoma cells by inducing mitochondria-dependent apoptosis.
Liu HM, Wu Q, Cao JQ, Wang X, Song Y, Mei WJ, Wang XC
European journal of pharmacology 2019 Jan 15;843:285-291
European journal of pharmacology 2019 Jan 15;843:285-291
The Roles of HK2 on Tumorigenesis of Cervical Cancer.
Liu C, Wang X, Zhang Y
Technology in cancer research & treatment 2019 Jan 1;18:1533033819871306
Technology in cancer research & treatment 2019 Jan 1;18:1533033819871306
Down-regulation of lncRNA OGFRP1 induces autophagy and growth inhibition by AKT/mTOR signaling pathway in HCAECs.
Zhang X, Liu J, Gu Y, Sun C, Qu F
Cell biology international 2019 Feb;43(2):158-166
Cell biology international 2019 Feb;43(2):158-166
Ubiquinol-cytochrome C reductase core protein II promotes tumorigenesis by facilitating p53 degradation.
Han Y, Wu P, Wang Z, Zhang Z, Sun S, Liu J, Gong S, Gao P, Iwakuma T, Molina-Vila MA, Chen BP, Zhang Y, Ji T, Mo Q, Chen P, Hu J, Wang S, Zhou J, Lu H, Gao Q
EBioMedicine 2019 Feb;40:92-105
EBioMedicine 2019 Feb;40:92-105
PPPDE1 promotes hepatocellular carcinoma development by negatively regulate p53 and apoptosis.
Xie X, Wang X, Liao W, Fei R, Wu N, Cong X, Chen Q, Wei L, Wang Y, Chen H
Apoptosis : an international journal on programmed cell death 2019 Feb;24(1-2):135-144
Apoptosis : an international journal on programmed cell death 2019 Feb;24(1-2):135-144
Discovery of a small molecule targeting autophagy via ATG4B inhibition and cell death of colorectal cancer cells in vitro and in vivo.
Fu Y, Hong L, Xu J, Zhong G, Gu Q, Gu Q, Guan Y, Zheng X, Dai Q, Luo X, Liu C, Huang Z, Yin XM, Liu P, Li M
Autophagy 2019 Feb;15(2):295-311
Autophagy 2019 Feb;15(2):295-311
Scutellarin synergistically enhances cisplatin effect against ovarian cancer cells through enhancing the ability of cisplatin binding to DNA.
Xie Z, Guo Z, Lei J, Yu J
European journal of pharmacology 2019 Feb 5;844:9-16
European journal of pharmacology 2019 Feb 5;844:9-16
MiR-223-3p functions as a tumor suppressor in lung squamous cell carcinoma by miR-223-3p-mutant p53 regulatory feedback loop.
Luo P, Wang Q, Ye Y, Zhang J, Lu D, Cheng L, Zhou H, Xie M, Wang B
Journal of experimental & clinical cancer research : CR 2019 Feb 12;38(1):74
Journal of experimental & clinical cancer research : CR 2019 Feb 12;38(1):74
DRAM2 acts as an oncogene in non-small cell lung cancer and suppresses the expression of p53.
Wudu M, Ren H, Hui L, Jiang J, Zhang S, Xu Y, Wang Q, Su H, Jiang X, Dao R, Qiu X
Journal of experimental & clinical cancer research : CR 2019 Feb 12;38(1):72
Journal of experimental & clinical cancer research : CR 2019 Feb 12;38(1):72
P53-induced miR-1249 inhibits tumor growth, metastasis, and angiogenesis by targeting VEGFA and HMGA2.
Chen X, Zeng K, Xu M, Liu X, Hu X, Xu T, He B, Pan Y, Sun H, Wang S
Cell death & disease 2019 Feb 12;10(2):131
Cell death & disease 2019 Feb 12;10(2):131
Dexmedetomidine attenuates lipopolysaccharide-induced liver oxidative stress and cell apoptosis in rats by increasing GSK-3β/MKP-1/Nrf2 pathway activity via the α2 adrenergic receptor.
Sha J, Zhang H, Zhao Y, Feng X, Hu X, Wang C, Song M, Fan H
Toxicology and applied pharmacology 2019 Feb 1;364:144-152
Toxicology and applied pharmacology 2019 Feb 1;364:144-152
Pifithrin-α enhancing anticancer effect of topotecan on p53-expressing cancer cells.
Guo J, Tang Q, Wang Q, Sun W, Pu Z, Wang J, Bao Y
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2019 Feb 1;128:61-72
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2019 Feb 1;128:61-72
Design, synthesis and molecular mechanisms of novel dual inhibitors of heat shock protein 90/phosphoinositide 3-kinase alpha (Hsp90/PI3Kα) against cutaneous melanoma.
Qin F, Wang Y, Jiang X, Wang Y, Zhang N, Wen X, Wang L, Jiang Q, He G
Journal of enzyme inhibition and medicinal chemistry 2019 Dec;34(1):909-926
Journal of enzyme inhibition and medicinal chemistry 2019 Dec;34(1):909-926
Shikonin exerts antitumor activity by causing mitochondrial dysfunction in hepatocellular carcinoma through PKM2-AMPK-PGC1α signaling pathway.
Liu B, Jin J, Zhang Z, Zuo L, Jiang M, Xie C
Biochemistry and cell biology = Biochimie et biologie cellulaire 2019 Aug;97(4):397-405
Biochemistry and cell biology = Biochimie et biologie cellulaire 2019 Aug;97(4):397-405
Visfatin Plays a Significant Role in Alleviating Lipopolysaccharide-Induced Apoptosis and Autophagy Through PI3K/AKT Signaling Pathway During Acute Lung Injury in Mice.
Wu XT, Ansari AR, Pang XX, Li HZ, Zhang ZW, Luo Y, Arshad M, Song H
Archivum immunologiae et therapiae experimentalis 2019 Aug;67(4):249-261
Archivum immunologiae et therapiae experimentalis 2019 Aug;67(4):249-261
Stepwise detection and evaluation reveal miR-10b and miR-222 as a remarkable prognostic pair for glioblastoma.
Sun B, Zhao X, Ming J, Liu X, Liu D, Jiang C
Oncogene 2019 Aug;38(33):6142-6157
Oncogene 2019 Aug;38(33):6142-6157
XRCC4, which is inhibited by PFDA, regulates DNA damage repair and cell chemosensitivity.
Liu F, Fan Z, Song N, Han M, Yan M, Guo LH, Jihui J, Liu S
Journal of cellular biochemistry 2019 Aug;120(8):12665-12676
Journal of cellular biochemistry 2019 Aug;120(8):12665-12676
Sinoporphyrin sodium based sonodynamic therapy induces anti-tumor effects in hepatocellular carcinoma and activates p53/caspase 3 axis.
Li E, Sun Y, Lv G, Li Y, Zhang Z, Hu Z, Cao W
The international journal of biochemistry & cell biology 2019 Aug;113:104-114
The international journal of biochemistry & cell biology 2019 Aug;113:104-114
Jingfukang induces anti-cancer activity through oxidative stress-mediated DNA damage in circulating human lung cancer cells.
Que Z, Zhou Z, Luo B, Dong C, Jiang Y, Li H, Tian J
BMC complementary and alternative medicine 2019 Aug 7;19(1):204
BMC complementary and alternative medicine 2019 Aug 7;19(1):204
Interferon regulatory factor-1 reverses chemoresistance by downregulating the expression of P-glycoprotein in gastric cancer.
Yuan J, Yin Z, Tan L, Zhu W, Tao K, Wang G, Shi W, Gao J
Cancer letters 2019 Aug 10;457:28-39
Cancer letters 2019 Aug 10;457:28-39
Nicotinamide phosphoribosyl transferase regulates cell growth via the Sirt1/P53 signaling pathway and is a prognosis marker in colorectal cancer.
Pan JH, Zhou H, Zhu SB, Huang JL, Zhao XX, Ding H, Qin L, Pan YL
Journal of cellular physiology 2019 Apr;234(4):4385-4395
Journal of cellular physiology 2019 Apr;234(4):4385-4395
Combination of dihydromyricetin and ondansetron strengthens antiproliferative efficiency of adriamycin in K562/ADR through downregulation of SORCIN: A new strategy of inhibiting P-glycoprotein.
Sun Y, Liu W, Wang C, Meng Q, Liu Z, Huo X, Yang X, Sun P, Sun H, Ma X, Peng J, Liu K
Journal of cellular physiology 2019 Apr;234(4):3685-3696
Journal of cellular physiology 2019 Apr;234(4):3685-3696
Potent effects of dioscin against hepatocellular carcinoma through regulating TP53-induced glycolysis and apoptosis regulator (TIGAR)-mediated apoptosis, autophagy, and DNA damage.
Mao Z, Han X, Chen D, Xu Y, Xu L, Yin L, Sun H, Qi Y, Fang L, Liu K, Peng J
British journal of pharmacology 2019 Apr;176(7):919-937
British journal of pharmacology 2019 Apr;176(7):919-937
Citrus alkaline extracts prevent fibroblast senescence to ameliorate pulmonary fibrosis via activation of COX-2.
Feng F, Wang Z, Li R, Wu Q, Gu C, Xu Y, Peng W, Han D, Zhou X, Wu J, He H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Apr;112:108669
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Apr;112:108669
Renoprotective effect of scutellarin on cisplatin-induced renal injury in mice: Impact on inflammation, apoptosis, and autophagy.
Sun CY, Nie J, Zheng ZL, Zhao J, Wu LM, Zhu Y, Su ZQ, Zheng GJ, Feng B
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Apr;112:108647
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Apr;112:108647
GTSE1 is involved in breast cancer progression in p53 mutation-dependent manner.
Lin F, Xie YJ, Zhang XK, Huang TJ, Xu HF, Mei Y, Liang H, Hu H, Lin ST, Luo FF, Lang YH, Peng LX, Qian CN, Huang BJ
Journal of experimental & clinical cancer research : CR 2019 Apr 8;38(1):152
Journal of experimental & clinical cancer research : CR 2019 Apr 8;38(1):152
YAP Aggravates Inflammatory Bowel Disease by Regulating M1/M2 Macrophage Polarization and Gut Microbial Homeostasis.
Zhou X, Li W, Wang S, Zhang P, Wang Q, Xiao J, Zhang C, Zheng X, Xu X, Xue S, Hui L, Ji H, Wei B, Wang H
Cell reports 2019 Apr 23;27(4):1176-1189.e5
Cell reports 2019 Apr 23;27(4):1176-1189.e5
Fangchinoline Ameliorates the Expressions of Angiogenic Molecule in Cerebral Ischemia Induced Neuronal Degeneration in Neonatal Rats.
Daicheng H, Shiwen X, Huaping Z, Yong L, Qianqian Z, Changxia H
Translational neuroscience 2018;9:117-122
Translational neuroscience 2018;9:117-122
N-Cadherin Attenuates High Glucose-Induced Nucleus Pulposus Cell Senescence Through Regulation of the ROS/NF-κB Pathway.
Hou G, Zhao H, Teng H, Li P, Xu W, Zhang J, Lv L, Guo Z, Wei L, Yao H, Xu Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;47(1):257-265
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;47(1):257-265
Long non-coding RNA MT1DP shunts the cellular defense to cytotoxicity through crosstalk with MT1H and RhoC in cadmium stress.
Gao M, Chen M, Li C, Xu M, Liu Y, Cong M, Sang N, Liu S
Cell discovery 2018;4:5
Cell discovery 2018;4:5
SS-31 Provides Neuroprotection by Reversing Mitochondrial Dysfunction after Traumatic Brain Injury.
Zhu Y, Wang H, Fang J, Dai W, Zhou J, Wang X, Zhou M
Oxidative medicine and cellular longevity 2018;2018:4783602
Oxidative medicine and cellular longevity 2018;2018:4783602
Activating the PGC-1α/TERT Pathway by Catalpol Ameliorates Atherosclerosis via Modulating ROS Production, DNA Damage, and Telomere Function: Implications on Mitochondria and Telomere Link.
Zhang Y, Wang C, Jin Y, Yang Q, Meng Q, Liu Q, Dai Y, Cai L, Liu Z, Liu K, Sun H
Oxidative medicine and cellular longevity 2018;2018:2876350
Oxidative medicine and cellular longevity 2018;2018:2876350
Realgar, a traditional Chinese medicine, induces apoptosis of HPV16-positive cervical cells through a HPV16 E7-related pathway.
Ding W, Ji T, Xiong W, Li T, Pu D, Liu R
Drug design, development and therapy 2018;12:3459-3469
Drug design, development and therapy 2018;12:3459-3469
Baicalin Protects Mice Brain From Apoptosis in Traumatic Brain Injury Model Through Activation of Autophagy.
Fang J, Zhu Y, Wang H, Cao B, Fei M, Niu W, Zhou Y, Wang X, Li X, Zhou M
Frontiers in neuroscience 2018;12:1006
Frontiers in neuroscience 2018;12:1006
Inhibition of survivin enhances radiosensitivity of esophageal cancer cells by switching radiation-induced senescence to apoptosis.
Liu X, Zhao Y, Zhang W, Gao Y, Huo M, Liu M, Xiao Z, Liang S, Xu N, Zhu H
OncoTargets and therapy 2018;11:3087-3100
OncoTargets and therapy 2018;11:3087-3100
Aloperine executes antitumor effects through the induction of apoptosis and cell cycle arrest in prostate cancer in vitro and in vivo.
Ling Z, Guan H, You Z, Wang C, Hu L, Zhang L, Wang Y, Chen S, Xu B, Chen M
OncoTargets and therapy 2018;11:2735-2743
OncoTargets and therapy 2018;11:2735-2743
S100B promotes chemoresistance in ovarian cancer stem cells by regulating p53.
Yang T, Cheng J, You J, Yan B, Liu H, Li F
Oncology reports 2018 Sep;40(3):1574-1582
Oncology reports 2018 Sep;40(3):1574-1582
Study on the potential way of hepatic cytotoxicity of N,N-dimethylformamide.
Li S, Wang C
Journal of biochemical and molecular toxicology 2018 Sep;32(9):e22190
Journal of biochemical and molecular toxicology 2018 Sep;32(9):e22190
Protective effect and mechanism of rat recombinant S100 calcium-binding protein A4 on oxidative stress injury of rat vascular endothelial cells.
Meng X, Gao X, Zhang Z, Zhou X, Wu L, Yang M, Wang K, Ren H, Sun B, Wang T
Oncology letters 2018 Sep;16(3):3614-3622
Oncology letters 2018 Sep;16(3):3614-3622
Rapid induction of apoptosis in tumor cells treated with a new platinum(II) complex based on amino-thiazolidinone.
Song XQ, Liu YH, Shao J, Zhang ZL, Xie CZ, Qiao X, Bao WG, Xu JY
European journal of medicinal chemistry 2018 Sep 5;157:188-197
European journal of medicinal chemistry 2018 Sep 5;157:188-197
Nogo-B receptor increases the resistance to tamoxifen in estrogen receptor-positive breast cancer cells.
Gao P, Wang X, Jin Y, Hu W, Duan Y, Shi A, Du Y, Song D, Yang M, Li S, Han B, Zhao G, Zhang H, Fan Z, Miao QR
Breast cancer research : BCR 2018 Sep 12;20(1):112
Breast cancer research : BCR 2018 Sep 12;20(1):112
Novel role of PKR in palmitate-induced Sirt1 inactivation and endothelial cell senescence.
Li Y, Peng Z, Wang C, Li L, Leng Y, Chen R, Yuan H, Zhou S, Zhang Z, Chen AF
American journal of physiology. Heart and circulatory physiology 2018 Sep 1;315(3):H571-H580
American journal of physiology. Heart and circulatory physiology 2018 Sep 1;315(3):H571-H580
UVB-inhibited H19 activates melanogenesis by paracrine effects.
Pei S, Huang J, Chen J, Hu S, Lei L, Fu C, Jiang L, Ding Y, Leng Y, Huang L, Xiang H, Zeng Q
Experimental dermatology 2018 Oct;27(10):1120-1125
Experimental dermatology 2018 Oct;27(10):1120-1125
Dachshund 1 is Differentially Expressed Between Male and Female Breast Cancer: A Matched Case-Control Study of Clinical Characteristics and Prognosis.
Cui Q, Kong D, Li Z, Ahiable P, Wang K, Wu K, Wu G
Clinical breast cancer 2018 Oct;18(5):e875-e882
Clinical breast cancer 2018 Oct;18(5):e875-e882
Effects of zerumbone on proliferation and apoptosis of esophageal cancer cells and on P53 and Bcl-2 expression levels.
Ma S, Lei Y, Zhang L, Wang J
Oncology letters 2018 Oct;16(4):4379-4383
Oncology letters 2018 Oct;16(4):4379-4383
Study on the expression of p53 and MMP-2 in patients with lung cancer after interventional therapy.
Zhang XS, Wang KY, Gao JQ, Li RJ, Guan QB, Song L
Oncology letters 2018 Oct;16(4):4291-4296
Oncology letters 2018 Oct;16(4):4291-4296
The oncoprotein HBXIP promotes human breast cancer growth through down-regulating p53 via miR-18b/MDM2 and pAKT/MDM2 pathways.
Li H, Wang Z, Jiang M, Fang RP, Shi H, Shen Y, Cai XL, Liu Q, Ye K, Fan SJ, Zhang WY, Ye LH
Acta pharmacologica Sinica 2018 Nov;39(11):1787-1796
Acta pharmacologica Sinica 2018 Nov;39(11):1787-1796
Protocatechuic acid inhibits the growth of ovarian cancer cells by inducing apoptosis and autophagy.
Xie Z, Guo Z, Wang Y, Lei J, Yu J
Phytotherapy research : PTR 2018 Nov;32(11):2256-2263
Phytotherapy research : PTR 2018 Nov;32(11):2256-2263
Insight into the negative impact of ionic liquid: A cytotoxicity mechanism of 1-methyl-3-octylimidazolium bromide.
Ma J, Li X
Environmental pollution (Barking, Essex : 1987) 2018 Nov;242(Pt B):1337-1345
Environmental pollution (Barking, Essex : 1987) 2018 Nov;242(Pt B):1337-1345
A biobank of patient-derived pediatric brain tumor models.
Brabetz S, Leary SES, Gröbner SN, Nakamoto MW, Şeker-Cin H, Girard EJ, Cole B, Strand AD, Bloom KL, Hovestadt V, Mack NL, Pakiam F, Schwalm B, Korshunov A, Balasubramanian GP, Northcott PA, Pedro KD, Dey J, Hansen S, Ditzler S, Lichter P, Chavez L, Jones DTW, Koster J, Pfister SM, Kool M, Olson JM
Nature medicine 2018 Nov;24(11):1752-1761
Nature medicine 2018 Nov;24(11):1752-1761
Inhibin B suppresses anoikis resistance and migration through the transforming growth factor-β signaling pathway in nasopharyngeal carcinoma.
Zou G, Ren B, Liu Y, Fu Y, Chen P, Li X, Luo S, He J, Gao G, Zeng Z, Xiong W, Li G, Huang Y, Xu K, Zhang W
Cancer science 2018 Nov;109(11):3416-3427
Cancer science 2018 Nov;109(11):3416-3427
Synergetic and Antagonistic Molecular Effects Mediated by the Feedback Loop of p53 and JNK between Saikosaponin D and SP600125 on Lung Cancer A549 Cells.
Chen X, Liu C, Zhao R, Zhao P, Wu J, Zhou N, Ying M
Molecular pharmaceutics 2018 Nov 5;15(11):4974-4984
Molecular pharmaceutics 2018 Nov 5;15(11):4974-4984
Radiation-induced premature cellular senescence involved in glomerular diseases in rats.
Aratani S, Tagawa M, Nagasaka S, Sakai Y, Shimizu A, Tsuruoka S
Scientific reports 2018 Nov 14;8(1):16812
Scientific reports 2018 Nov 14;8(1):16812
Comparative characterization of SHED and DPSCs during extended cultivation in vitro.
Wang H, Zhong Q, Yang T, Qi Y, Fu M, Yang X, Qiao L, Ling Q, Liu S, Zhao Y
Molecular medicine reports 2018 May;17(5):6551-6559
Molecular medicine reports 2018 May;17(5):6551-6559
Ginsenoside Rg1 ameliorates testicular senescence changes in D‑gal‑induced aging mice via anti‑inflammatory and antioxidative mechanisms.
Wang ZL, Chen LB, Qiu Z, Chen XB, Liu Y, Li J, Wang L, Wang YP
Molecular medicine reports 2018 May;17(5):6269-6276
Molecular medicine reports 2018 May;17(5):6269-6276
Procyanidin from peanut skin induces antiproliferative effect in human prostate carcinoma cells DU145.
Chen L, Yan F, Chen W, Zhao L, Zhang J, Lu Q, Liu R
Chemico-biological interactions 2018 May 25;288:12-23
Chemico-biological interactions 2018 May 25;288:12-23
Metformin-induced activation of AMPK inhibits the proliferation and migration of human aortic smooth muscle cells through upregulation of p53 and IFI16.
Hao B, Xiao Y, Song F, Long X, Huang J, Tian M, Deng S, Wu Q
International journal of molecular medicine 2018 Mar;41(3):1365-1376
International journal of molecular medicine 2018 Mar;41(3):1365-1376
AATF suppresses apoptosis, promotes proliferation and is critical for Kras-driven lung cancer.
Welcker D, Jain M, Khurshid S, Jokić M, Höhne M, Schmitt A, Frommolt P, Niessen CM, Spiro J, Persigehl T, Wittersheim M, Büttner R, Fanciulli M, Schermer B, Reinhardt HC, Benzing T, Höpker K
Oncogene 2018 Mar;37(11):1503-1518
Oncogene 2018 Mar;37(11):1503-1518
Hematopoietic Substrate-1-Associated Protein X-1 Regulates the Proliferation and Apoptosis of Endothelial Progenitor Cells Through Akt Pathway Modulation.
Guo XB, Deng X, Wei Y
Stem cells (Dayton, Ohio) 2018 Mar;36(3):406-419
Stem cells (Dayton, Ohio) 2018 Mar;36(3):406-419
Oxidative stress-mediated p53/p21(WAF1/CIP1) pathway may be involved in microcystin-LR-induced cytotoxicity in HepG2 cells.
Ma J, Li Y, Wu M, Li X
Chemosphere 2018 Mar;194:773-783
Chemosphere 2018 Mar;194:773-783
Potent hydrazone derivatives targeting esophageal cancer cells.
Li LY, Peng JD, Zhou W, Qiao H, Deng X, Li ZH, Li JD, Fu YD, Li S, Sun K, Liu HM, Zhao W
European journal of medicinal chemistry 2018 Mar 25;148:359-371
European journal of medicinal chemistry 2018 Mar 25;148:359-371
Epidermal Growth Factor, through Alleviating Oxidative Stress, Protect IPEC-J2 Cells from Lipopolysaccharides-Induced Apoptosis.
Tang X, Liu B, Wang X, Yu Q, Fang R
International journal of molecular sciences 2018 Mar 14;19(3)
International journal of molecular sciences 2018 Mar 14;19(3)
Effects of three-dimensional collagen scaffolds on the expression profiles and biological functions of glioma cells.
Jia W, Jiang X, Liu W, Wang L, Zhu B, Zhu H, Liu X, Zhong M, Xie D, Huang W, Jia W, Li S, Liu X, Zuo X, Cheng D, Dai J, Ren C
International journal of oncology 2018 Jun;52(6):1787-1800
International journal of oncology 2018 Jun;52(6):1787-1800
Atrazine exposure improves the proliferation of H22 cells in vitro and in vivo.
Tian Y, He J, Liu N, Huang D, Liu Z, Yang Y, Chen J, Zhao B, Zhao S, Liang B
RSC advances 2018 Jun 13;8(39):21759-21767
RSC advances 2018 Jun 13;8(39):21759-21767
3-O-acetyl-11-keto-β-boswellic acid exerts anti-tumor effects in glioblastoma by arresting cell cycle at G2/M phase.
Li W, Liu J, Fu W, Zheng X, Ren L, Liu S, Wang J, Ji T, Du G
Journal of experimental & clinical cancer research : CR 2018 Jul 3;37(1):132
Journal of experimental & clinical cancer research : CR 2018 Jul 3;37(1):132
Heme oxygenase-1 ameliorates oxidative stress-induced endothelial senescence via regulating endothelial nitric oxide synthase activation and coupling.
Luo W, Wang Y, Yang H, Dai C, Hong H, Li J, Liu Z, Guo Z, Chen X, He P, Li Z, Li F, Jiang J, Liu P, Li Z
Aging 2018 Jul 24;10(7):1722-1744
Aging 2018 Jul 24;10(7):1722-1744
Tripartite motif 31 promotes resistance to anoikis of hepatocarcinoma cells through regulation of p53-AMPK axis.
Guo P, Qiu Y, Ma X, Li T, Ma X, Zhu L, Lin Y, Han L
Experimental cell research 2018 Jul 1;368(1):59-66
Experimental cell research 2018 Jul 1;368(1):59-66
Dietary restriction delays the secretion of senescence associated secretory phenotype by reducing DNA damage response in the process of renal aging.
Wang W, Cai G, Chen X
Experimental gerontology 2018 Jul 1;107:4-10
Experimental gerontology 2018 Jul 1;107:4-10
Triggering p53 activation is essential in ziyuglycoside I-induced human retinoblastoma WERI-Rb-1 cell apoptosis.
Zhu X, Wang K, Yao Y, Zhang K, Zhou F, Zhu L
Journal of biochemical and molecular toxicology 2018 Jan;32(1)
Journal of biochemical and molecular toxicology 2018 Jan;32(1)
Downregulation of TRIM28 inhibits growth and increases apoptosis of nude mice with non‑small cell lung cancer xenografts.
Liu L, Zhang L, Wang J, Zhao X, Xu Q, Lu Y, Zuo Y, Chen L, Du J, Lian Y, Zhang Q
Molecular medicine reports 2018 Jan;17(1):835-842
Molecular medicine reports 2018 Jan;17(1):835-842
Atorvastatin exerts inhibitory effect on endothelial senescence in hyperlipidemic rats through a mechanism involving down-regulation of miR-21-5p/203a-3p.
Zhang JJ, Zhang YZ, Peng JJ, Li NS, Xiong XM, Ma QL, Luo XJ, Liu B, Peng J
Mechanisms of ageing and development 2018 Jan;169:10-18
Mechanisms of ageing and development 2018 Jan;169:10-18
Experimental evidence of good efficacy and reduced toxicity with peptide-doxorubicin to treat gastric cancer.
Zhang J, Yuan JP, Wang Q, Shao LH, Liu SP, Firestone RA, Hong YP, Li JG, Xin YC, Li Y
Oncotarget 2018 Jan 5;9(2):1957-1968
Oncotarget 2018 Jan 5;9(2):1957-1968
PLZF inhibits proliferation and metastasis of gallbladder cancer by regulating IFIT2.
Shen H, Zhan M, Zhang Y, Huang S, Xu S, Huang X, He M, Yao Y, Man M, Wang J
Cell death & disease 2018 Jan 22;9(2):71
Cell death & disease 2018 Jan 22;9(2):71
Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral β-lactam bridged combretastatin A-4 analogues as potent antitumor agents.
Zhou P, Liang Y, Zhang H, Jiang H, Feng K, Xu P, Wang J, Wang X, Ding K, Luo C, Liu M, Wang Y
European journal of medicinal chemistry 2018 Jan 20;144:817-842
European journal of medicinal chemistry 2018 Jan 20;144:817-842
The Potential Roles of the Apoptosis-Related Protein PDRG1 in Diapause Embryo Restarting of Artemia sinica.
Zhang W, Yao F, Zhang H, Li N, Zou X, Sui L, Hou L
International journal of molecular sciences 2018 Jan 2;19(1)
International journal of molecular sciences 2018 Jan 2;19(1)
High expression of TMEM40 is associated with the malignant behavior and tumorigenesis in bladder cancer.
Zhang ZF, Zhang HR, Zhang QY, Lai SY, Feng YZ, Zhou Y, Zheng SR, Shi R, Zhou JY
Journal of translational medicine 2018 Jan 19;16(1):9
Journal of translational medicine 2018 Jan 19;16(1):9
Inhibition of neddylation by MLN4924 improves neointimal hyperplasia and promotes apoptosis of vascular smooth muscle cells through p53 and p62.
Ai TJ, Sun JY, Du LJ, Shi C, Li C, Sun XN, Liu Y, Li L, Xia Z, Jia L, Liu J, Duan SZ
Cell death and differentiation 2018 Feb;25(2):319-329
Cell death and differentiation 2018 Feb;25(2):319-329
N‑cadherin attenuates nucleus pulposus cell senescence under high‑magnitude compression.
Niu M, Ma F, Qian J, Li J, Wang T, Gao Y, Jin J
Molecular medicine reports 2018 Feb;17(2):2879-2884
Molecular medicine reports 2018 Feb;17(2):2879-2884
SIRT3 deacetylates and promotes degradation of P53 in PTEN-defective non-small cell lung cancer.
Xiong Y, Wang L, Wang S, Wang M, Zhao J, Zhang Z, Li X, Jia L, Han Y
Journal of cancer research and clinical oncology 2018 Feb;144(2):189-198
Journal of cancer research and clinical oncology 2018 Feb;144(2):189-198
Upregulation of the ALDOA/DNA-PK/p53 pathway by dietary restriction suppresses tumor growth.
Ma D, Chen X, Zhang PY, Zhang H, Wei LJ, Hu S, Tang JZ, Zhou MT, Xie C, Ou R, Xu Y, Tang KF
Oncogene 2018 Feb 22;37(8):1041-1048
Oncogene 2018 Feb 22;37(8):1041-1048
Clinorotation-induced autophagy via HDM2-p53-mTOR pathway enhances cell migration in vascular endothelial cells.
Li CF, Sun JX, Gao Y, Shi F, Pan YK, Wang YC, Sun XQ
Cell death & disease 2018 Feb 2;9(2):147
Cell death & disease 2018 Feb 2;9(2):147
NIT1 suppresses tumour proliferation by activating the TGFβ1-Smad2/3 signalling pathway in colorectal cancer.
Lin C, Zhang J, Lu Y, Li X, Zhang W, Zhang W, Lin W, Zheng L, Li X
Cell death & disease 2018 Feb 15;9(3):263
Cell death & disease 2018 Feb 15;9(3):263
MYL6B, a myosin light chain, promotes MDM2-mediated p53 degradation and drives HCC development.
Xie X, Wang X, Liao W, Fei R, Wu N, Cong X, Chen Q, Wei L, Wang Y, Chen H
Journal of experimental & clinical cancer research : CR 2018 Feb 13;37(1):28
Journal of experimental & clinical cancer research : CR 2018 Feb 13;37(1):28
mTORC2 facilitates endothelial cell senescence by suppressing Nrf2 expression via the Akt/GSK-3β/C/EBPα signaling pathway.
Yang HW, Hong HL, Luo WW, Dai CM, Chen XY, Wang LP, Li Q, Li ZQ, Liu PQ, Li ZM
Acta pharmacologica Sinica 2018 Dec;39(12):1837-1846
Acta pharmacologica Sinica 2018 Dec;39(12):1837-1846
PTBP3 splicing factor promotes hepatocellular carcinoma by destroying the splicing balance of NEAT1 and pre-miR-612.
Yang X, Qu S, Wang L, Zhang H, Yang Z, Wang J, Dai B, Tao K, Shang R, Liu Z, Li X, Zhang Z, Xia C, Ma B, Liu W, Li H, Dou K
Oncogene 2018 Dec;37(50):6399-6413
Oncogene 2018 Dec;37(50):6399-6413
1,3-Dichloro-2-Propanol inhibits autophagy via P53/AMPK/mTOR pathway in HepG2 cells.
Cheng B, Lu J, Li T, Meng Z, Liu M, Sun M, Guan S
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 Dec;122:143-150
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 Dec;122:143-150
Urea transport B gene induces melanoma B16 cell death via activation of p53 and mitochondrial apoptosis.
Liu L, Sun Y, Zhao Y, Wang Q, Guo H, Guo R, Liu Y, Fu S, Zhang L, Li Y, Meng Y
Cancer science 2018 Dec;109(12):3762-3773
Cancer science 2018 Dec;109(12):3762-3773
Xin-Jia-Xiang-Ru-Yin alleviated H1N1-induced acute lung injury and inhibited the IFN-γ-related regulatory pathway in summer flu.
Li Q, Pang P, Zheng K, Sun L, Wang J, Chen X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Dec;108:201-207
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Dec;108:201-207
Long non-coding RNA GClnc1 promotes tumorigenesis in osteosarcoma by inhibiting p53 signaling.
Sui Y, Han Y, Zhao X, Li D, Li G
Biochemical and biophysical research communications 2018 Dec 9;507(1-4):36-42
Biochemical and biophysical research communications 2018 Dec 9;507(1-4):36-42
Activation of p53 by costunolide blocks glutaminolysis and inhibits proliferation in human colorectal cancer cells.
Hu M, Liu L, Yao W
Gene 2018 Dec 15;678:261-269
Gene 2018 Dec 15;678:261-269
Synthesis and Discovery Novel Anti-Cancer Stem Cells Compounds Derived from the Natural Triterpenoic Acids.
Liu X, Li B, Zhang Z, Wei Y, Xu Z, Qin S, Liu N, Zhao R, Peng J, Yang G, Qi M, Liu T, Xie M, Liu S, Gao X, Lu C, Zhu L, Long X, Kang H, Sun T, Zhou H, Wei M, Yang G, Yang C
Journal of medicinal chemistry 2018 Dec 13;61(23):10814-10833
Journal of medicinal chemistry 2018 Dec 13;61(23):10814-10833
Overexpression of FOXQ1 enhances anti-senescence and migration effects of human umbilical cord mesenchymal stem cells in vitro and in vivo.
Zhang T, Wang P, Liu Y, Zhou J, Shi Z, Cheng K, Huang T, Wang X, Yang GL, Yang B, Ma S, Guan F
Cell and tissue research 2018 Aug;373(2):379-393
Cell and tissue research 2018 Aug;373(2):379-393
DNA damage triggers tubular endoplasmic reticulum extension to promote apoptosis by facilitating ER-mitochondria signaling.
Zheng P, Chen Q, Tian X, Qian N, Chai P, Liu B, Hu J, Blackstone C, Zhu D, Teng J, Chen J
Cell research 2018 Aug;28(8):833-854
Cell research 2018 Aug;28(8):833-854
Protective role of fenofibrate in sepsis-induced acute kidney injury in BALB/c mice.
Pei Z, Deng S, Xie D, Lv M, Guo W, Liu D, Zheng Z, Long X
RSC advances 2018 Aug 7;8(50):28510-28517
RSC advances 2018 Aug 7;8(50):28510-28517
A novel Anti-Cancer Stem Cells compound optimized from the natural symplostatin 4 scaffold inhibits Wnt/β-catenin signaling pathway.
Liu S, Gao X, Zhang L, Qin S, Wei M, Liu N, Zhao R, Li B, Meng Y, Lin G, Lu C, Liu X, Xie M, Liu T, Zhou H, Qi M, Yang G, Yang C
European journal of medicinal chemistry 2018 Aug 5;156:21-42
European journal of medicinal chemistry 2018 Aug 5;156:21-42
Nucleus pulposus cell senescence is alleviated by resveratrol through regulating the ROS/NF-κB pathway under high-magnitude compression.
Jiang Y, Dong G, Song Y
Bioscience reports 2018 Aug 31;38(4)
Bioscience reports 2018 Aug 31;38(4)
Fenofibrate Exerts Protective Effects in Diabetic Retinopathy via Inhibition of the ANGPTL3 Pathway.
Wang N, Zou C, Zhao S, Wang Y, Han C, Zheng Z
Investigative ophthalmology & visual science 2018 Aug 1;59(10):4210-4217
Investigative ophthalmology & visual science 2018 Aug 1;59(10):4210-4217
Traditional Chinese Medicine CFF-1 induced cell growth inhibition, autophagy, and apoptosis via inhibiting EGFR-related pathways in prostate cancer.
Wu Z, Zhu Q, Yin Y, Kang D, Cao R, Tian Q, Zhang Y, Lu S, Liu P
Cancer medicine 2018 Apr;7(4):1546-1559
Cancer medicine 2018 Apr;7(4):1546-1559
Anticancer activity and potential mechanisms of 1C, a ginseng saponin derivative, on prostate cancer cells.
Wang X, Su GY, Zhao C, Qu FZ, Wang P, Zhao YQ
Journal of ginseng research 2018 Apr;42(2):133-143
Journal of ginseng research 2018 Apr;42(2):133-143
Targeting P-glycoprotein and SORCIN: Dihydromyricetin strengthens anti-proliferative efficiency of adriamycin via MAPK/ERK and Ca(2+) -mediated apoptosis pathways in MCF-7/ADR and K562/ADR.
Sun Y, Wang C, Meng Q, Liu Z, Huo X, Sun P, Sun H, Ma X, Peng J, Liu K
Journal of cellular physiology 2018 Apr;233(4):3066-3079
Journal of cellular physiology 2018 Apr;233(4):3066-3079
The enhancement of siPLK1 penetration across BBB and its anti glioblastoma activity in vivo by magnet and transferrin co-modified nanoparticle.
Liu DZ, Cheng Y, Cai RQ, Wang Bd WW, Cui H, Liu M, Zhang BL, Mei QB, Zhou SY
Nanomedicine : nanotechnology, biology, and medicine 2018 Apr;14(3):991-1003
Nanomedicine : nanotechnology, biology, and medicine 2018 Apr;14(3):991-1003
Knockdown of long noncoding RNA MEG3 impairs VEGF-stimulated endothelial sprouting angiogenesis via modulating VEGFR2 expression in human umbilical vein endothelial cells.
Ruan W, Zhao F, Zhao S, Zhang L, Shi L, Pang T
Gene 2018 Apr 5;649:32-39
Gene 2018 Apr 5;649:32-39
MicroRNA-326 sensitizes human glioblastoma cells to curcumin via the SHH/GLI1 signaling pathway.
Yin S, Du W, Wang F, Han B, Cui Y, Yang D, Chen H, Liu D, Liu X, Zhai X, Jiang C
Cancer biology & therapy 2018 Apr 3;19(4):260-270
Cancer biology & therapy 2018 Apr 3;19(4):260-270
Thymoquinone protects against cardiac damage from doxorubicin-induced heart failure in Sprague-Dawley rats.
Pei Z, Hu J, Bai Q, Liu B, Cheng D, Liu H, Na R, Yu Q
RSC advances 2018 Apr 17;8(26):14633-14639
RSC advances 2018 Apr 17;8(26):14633-14639
Nogo-B receptor increases the resistance of estrogen receptor positive breast cancer to paclitaxel.
Jin Y, Hu W, Liu T, Rana U, Aguilera-Barrantes I, Kong A, Kumar SN, Wang B, Gao P, Wang X, Duan Y, Shi A, Song D, Yang M, Li S, Han B, Zhao G, Fan Z, Miao QR
Cancer letters 2018 Apr 10;419:233-244
Cancer letters 2018 Apr 10;419:233-244
Berberine Enhances Chemosensitivity and Induces Apoptosis Through Dose-orchestrated AMPK Signaling in Breast Cancer.
Pan Y, Zhang F, Zhao Y, Shao D, Zheng X, Chen Y, He K, Li J, Chen L
Journal of Cancer 2017;8(9):1679-1689
Journal of Cancer 2017;8(9):1679-1689
H(2)S Donor NaHS Changes the Production of Endogenous H(2)S and NO in D-Galactose-Induced Accelerated Ageing.
Wu W, Hou CL, Mu XP, Sun C, Zhu YC, Wang MJ, Lv QZ
Oxidative medicine and cellular longevity 2017;2017:5707830
Oxidative medicine and cellular longevity 2017;2017:5707830
Berberine Reverses Hypoxia-induced Chemoresistance in Breast Cancer through the Inhibition of AMPK- HIF-1α.
Pan Y, Shao D, Zhao Y, Zhang F, Zheng X, Tan Y, He K, Li J, Chen L
International journal of biological sciences 2017;13(6):794-803
International journal of biological sciences 2017;13(6):794-803
Lyophilized Powder of Catalpol and Puerarin Protected Cerebral Vessels from Ischemia by Its Anti-apoptosis on Endothelial Cells.
Liu Y, Tang Q, Shao S, Chen Y, Chen W, Xu X
International journal of biological sciences 2017;13(3):327-338
International journal of biological sciences 2017;13(3):327-338
17beta-estradiol Attenuates TNF-α-Induced Premature Senescence of Nucleus Pulposus Cells through Regulating the ROS/NF-κB Pathway.
Li P, Gan Y, Xu Y, Wang L, Ouyang B, Zhang C, Luo L, Zhao C, Zhou Q
International journal of biological sciences 2017;13(2):145-156
International journal of biological sciences 2017;13(2):145-156
HAX-1 Protects Glioblastoma Cells from Apoptosis through the Akt1 Pathway.
Deng X, Song L, Zhao W, Wei Y, Guo XB
Frontiers in cellular neuroscience 2017;11:420
Frontiers in cellular neuroscience 2017;11:420
Inhibition effect of tacrolimus and platelet-derived growth factor-BB on restenosis after vascular intimal injury.
Ma X, Jiang C, Li Y, Feng L, Liu J, Wang J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Sep;93:180-189
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Sep;93:180-189
High-grade serous carcinomas arise in the mouse oviduct via defects linked to the human disease.
Zhai Y, Wu R, Kuick R, Sessine MS, Schulman S, Green M, Fearon ER, Cho KR
The Journal of pathology 2017 Sep;243(1):16-25
The Journal of pathology 2017 Sep;243(1):16-25
MDM2 Contributes to High Glucose-Induced Glomerular Mesangial Cell Proliferation and Extracellular Matrix Accumulation via Notch1.
Lei CT, Tang H, Ye C, You CQ, Zhang J, Zhang CY, Xiong W, Su H, Zhang C
Scientific reports 2017 Sep 4;7(1):10393
Scientific reports 2017 Sep 4;7(1):10393
2-Acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylcarbonylamino) phenyl carbamoylsulfanyl] propionic acid, a glutathione reductase inhibitor, induces G(2)/M cell cycle arrest through generation of thiol oxidative stress in human esophageal cancer cells.
Li X, Jiang Z, Feng J, Zhang X, Wu J, Chen W
Oncotarget 2017 Sep 22;8(37):61846-61860
Oncotarget 2017 Sep 22;8(37):61846-61860
ATM-deficiency increases genomic instability and metastatic potential in a mouse model of pancreatic cancer.
Drosos Y, Escobar D, Chiang MY, Roys K, Valentine V, Valentine MB, Rehg JE, Sahai V, Begley LA, Ye J, Paul L, McKinnon PJ, Sosa-Pineda B
Scientific reports 2017 Sep 11;7(1):11144
Scientific reports 2017 Sep 11;7(1):11144
Misidentified Human Gene Functions with Mouse Models: The Case of the Retinoblastoma Gene Family in Senescence.
Alessio N, Capasso S, Ferone A, Di Bernardo G, Cipollaro M, Casale F, Peluso G, Giordano A, Galderisi U
Neoplasia (New York, N.Y.) 2017 Oct;19(10):781-790
Neoplasia (New York, N.Y.) 2017 Oct;19(10):781-790
HSF4 regulates lens fiber cell differentiation by activating p53 and its downstream regulators.
Gao M, Huang Y, Wang L, Huang M, Liu F, Liao S, Yu S, Lu Z, Han S, Hu X, Qu Z, Liu X, Assefa Yimer T, Yang L, Tang Z, Li DW, Liu M
Cell death & disease 2017 Oct 5;8(10):e3082
Cell death & disease 2017 Oct 5;8(10):e3082
Florfenicol-induced Mitochondrial Dysfunction Suppresses Cell Proliferation and Autophagy in Fibroblasts.
Hu D, Cao S, Zhang G, Xiao Y, Liu S, Shang Y
Scientific reports 2017 Oct 19;7(1):13554
Scientific reports 2017 Oct 19;7(1):13554
Insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) promotes lung tumorigenesis via attenuating p53 stability.
Zhao W, Lu D, Liu L, Cai J, Zhou Y, Yang Y, Zhang Y, Zhang J
Oncotarget 2017 Nov 7;8(55):93672-93687
Oncotarget 2017 Nov 7;8(55):93672-93687
Core 3 mucin-type O-glycan restoration in colorectal cancer cells promotes MUC1/p53/miR-200c-dependent epithelial identity.
Ye J, Wei X, Shang Y, Pan Q, Yang M, Tian Y, He Y, Peng Z, Chen L, Chen W, Wang R
Oncogene 2017 Nov 16;36(46):6391-6407
Oncogene 2017 Nov 16;36(46):6391-6407
Oridonin induces G2/M cell cycle arrest and apoptosis in human oral squamous cell carcinoma.
Wang H, Zhu L, Feng X, Zhang H, Luo Q, Chen F
European journal of pharmacology 2017 Nov 15;815:282-289
European journal of pharmacology 2017 Nov 15;815:282-289
Quercetin exerts synergetic anti-cancer activity with 10-hydroxy camptothecin.
Tang Q, Ji F, Wang J, Guo L, Li Y, Bao Y
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2017 Nov 15;109:223-232
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2017 Nov 15;109:223-232
Tributylphosphate (TBP) and tris (2-butoxyethyl) phosphate (TBEP) induced apoptosis and cell cycle arrest in HepG2 cells.
Ren G, Hu J, Shang Y, Zhong Y, Yu Z, An J
Toxicology research 2017 Nov 1;6(6):902-911
Toxicology research 2017 Nov 1;6(6):902-911
TRPC5 channel modulates endothelial cells senescence.
Li Z, Guo G, Wang H, Si X, Zhou G, Xiong Y, Li S, Dai R, Yang C
European journal of pharmacology 2017 May 5;802:27-35
European journal of pharmacology 2017 May 5;802:27-35
Vascular endothelial cells senescence is associated with NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation via reactive oxygen species (ROS)/thioredoxin-interacting protein (TXNIP) pathway.
Yin Y, Zhou Z, Liu W, Chang Q, Sun G, Dai Y
The international journal of biochemistry & cell biology 2017 Mar;84:22-34
The international journal of biochemistry & cell biology 2017 Mar;84:22-34
Therapeutic Targeting of RNA Polymerase I With the Small-Molecule CX-5461 for Prevention of Arterial Injury-Induced Neointimal Hyperplasia.
Ye Q, Pang S, Zhang W, Guo X, Wang J, Zhang Y, Liu Y, Wu X, Jiang F
Arteriosclerosis, thrombosis, and vascular biology 2017 Mar;37(3):476-484
Arteriosclerosis, thrombosis, and vascular biology 2017 Mar;37(3):476-484
12-Chloracetyl-PPD, a novel dammarane derivative, shows anti-cancer activity via delay the progression of cell cycle G2/M phase and reactive oxygen species-mediate cell apoptosis.
Wang X, Sun YY, Zhao C, Qu FZ, Zhao YQ
European journal of pharmacology 2017 Mar 5;798:49-56
European journal of pharmacology 2017 Mar 5;798:49-56
Y14 governs p53 expression and modulates DNA damage sensitivity.
Lu CC, Lee CC, Tseng CT, Tarn WY
Scientific reports 2017 Mar 31;7:45558
Scientific reports 2017 Mar 31;7:45558
Cytotoxic effects of docetaxel as a candidate drug of drug-eluting stent on human umbilical vein endothelial cells and the signaling pathway of cell migration inhibition, adhesion delay and shape change.
Hu T, Yang C, Fu M, Yang J, Du R, Ran X, Yin T, Wang G
Regenerative biomaterials 2017 Jun;4(3):167-178
Regenerative biomaterials 2017 Jun;4(3):167-178
miR-21-5p/203a-3p promote ox-LDL-induced endothelial cell senescence through down-regulation of mitochondrial fission protein Drp1.
Zhang JJ, Liu WQ, Peng JJ, Ma QL, Peng J, Luo XJ
Mechanisms of ageing and development 2017 Jun;164:8-19
Mechanisms of ageing and development 2017 Jun;164:8-19
Renal cell carcinoma with synchronous ipsilateral urothelial carcinoma of the renal pelvis.
Lu Q, Zhuang J, Guo H
Oncology letters 2017 Jun;13(6):4521-4525
Oncology letters 2017 Jun;13(6):4521-4525
Adiponectin modulates oxidative stress-induced mitophagy and protects C2C12 myoblasts against apoptosis.
Ren Y, Li Y, Yan J, Ma M, Zhou D, Xue Z, Zhang Z, Liu H, Yang H, Jia L, Zhang L, Zhang Q, Mu S, Zhang R, Da Y
Scientific reports 2017 Jun 9;7(1):3209
Scientific reports 2017 Jun 9;7(1):3209
Arginine deiminase expressed in vivo, driven by human telomerase reverse transcriptase promoter, displays high hepatoma targeting and oncolytic efficiency.
Jiang H, Guo S, Xiao D, Bian X, Wang J, Wang Y, Zhou H, Cai J, Zheng Z
Oncotarget 2017 Jun 6;8(23):37694-37704
Oncotarget 2017 Jun 6;8(23):37694-37704
Homoharringtonine suppresses imatinib resistance via the Bcl-6/p53 pathway in chronic myeloid leukemia cell lines.
Wang Q, Ding W, Ding Y, Ma J, Qian Z, Shao J, Li Y
Oncotarget 2017 Jun 6;8(23):37594-37604
Oncotarget 2017 Jun 6;8(23):37594-37604
Molecular characterization of breast cancer cell lines through multiple omic approaches.
Smith SE, Mellor P, Ward AK, Kendall S, McDonald M, Vizeacoumar FS, Vizeacoumar FJ, Napper S, Anderson DH
Breast cancer research : BCR 2017 Jun 5;19(1):65
Breast cancer research : BCR 2017 Jun 5;19(1):65
0404 inhibits hepatocellular carcinoma through a p53/miR-34a/SIRT1 positive feedback loop.
Xia C, Shui L, Lou G, Ye B, Zhu W, Wang J, Wu S, Xu X, Mao L, Xu W, Chen Z, Liu Y, Zheng M
Scientific reports 2017 Jun 30;7(1):4396
Scientific reports 2017 Jun 30;7(1):4396
Variant 2 of KIAA0101, antagonizing its oncogenic variant 1, might be a potential therapeutic strategy in hepatocellular carcinoma.
Liu L, Liu Y, Chen X, Wang M, Zhou Y, Zhou P, Li W, Zhu F
Oncotarget 2017 Jul 4;8(27):43990-44003
Oncotarget 2017 Jul 4;8(27):43990-44003
Anthocyanins from Black Chokeberry (Aroniamelanocarpa Elliot) Delayed Aging-Related Degenerative Changes of Brain.
Wei J, Zhang G, Zhang X, Xu D, Gao J, Fan J, Zhou Z
Journal of agricultural and food chemistry 2017 Jul 26;65(29):5973-5984
Journal of agricultural and food chemistry 2017 Jul 26;65(29):5973-5984
Mitochondria-Associated Apoptosis in Human Melanoma Cells Induced by Cardanol Monoene from Cashew Nut Shell Liquid.
Su WC, Lin YF, Yu XP, Wang YX, Lin XD, Su QZ, Shen DY, Chen QX
Journal of agricultural and food chemistry 2017 Jul 19;65(28):5620-5631
Journal of agricultural and food chemistry 2017 Jul 19;65(28):5620-5631
The synthetic antihyperlipidemic drug potassium piperate selectively kills breast cancer cells through inhibiting G1-S-phase transition and inducing apoptosis.
Fan L, Cao X, Yan H, Wang Q, Tian X, Zhang L, He X, Borjihan G, Morigen
Oncotarget 2017 Jul 18;8(29):47250-47268
Oncotarget 2017 Jul 18;8(29):47250-47268
Nurr1 promotes intestinal regeneration after ischemia/reperfusion injury by inhibiting the expression of p21 (Waf1/Cip1).
Zu G, Yao J, Ji A, Ning S, Luo F, Li Z, Feng D, Rui Y, Li Y, Wang G, Tian X
Journal of molecular medicine (Berlin, Germany) 2017 Jan;95(1):83-95
Journal of molecular medicine (Berlin, Germany) 2017 Jan;95(1):83-95
Hypoxia-inducible factor-2α promotes hepatocyte apoptosis during cholestasis.
Hua X, Lu T, Zhang J, Miao Q, Bian Z, Zhang H, Huang S, Lin W, Xi Z, Zhang M, Chen Q, Ma X, Zhang J, Xia Q
Hepatology research : the official journal of the Japan Society of Hepatology 2017 Jan;47(1):95-102
Hepatology research : the official journal of the Japan Society of Hepatology 2017 Jan;47(1):95-102
The role of the ATM/Chk/P53 pathway in mediating DNA damage in hand-foot syndrome induced by PLD.
Yang J, Qiao L, Zeng Z, Wang J, Zhu T, Wei J, Wu M, Ye S, Huang X, Ma D, Liu R, Gao Q
Toxicology letters 2017 Jan 4;265:131-139
Toxicology letters 2017 Jan 4;265:131-139
Targeting P-glycoprotein function, p53 and energy metabolism: Combination of metformin and 2-deoxyglucose reverses the multidrug resistance of MCF-7/Dox cells to doxorubicin.
Xue C, Wang C, Sun Y, Meng Q, Liu Z, Huo X, Sun P, Sun H, Ma X, Ma X, Peng J, Liu K
Oncotarget 2017 Jan 31;8(5):8622-8632
Oncotarget 2017 Jan 31;8(5):8622-8632
CRB3 regulates contact inhibition by activating the Hippo pathway in mammary epithelial cells.
Mao X, Li P, Wang Y, Liang Z, Liu J, Li J, Jiang Y, Bao G, Li L, Zhu B, Ren Y, Zhao X, Zhang J, Liu Y, Yang J, Liu P
Cell death & disease 2017 Jan 12;8(1):e2546
Cell death & disease 2017 Jan 12;8(1):e2546
ISG15 inhibits cancer cell growth and promotes apoptosis.
Zhou MJ, Chen FZ, Chen HC, Wan XX, Zhou X, Fang Q, Zhang DZ
International journal of molecular medicine 2017 Feb;39(2):446-452
International journal of molecular medicine 2017 Feb;39(2):446-452
S100B Mediates Stemness of Ovarian Cancer Stem-Like Cells Through Inhibiting p53.
Yang T, Cheng J, Yang Y, Qi W, Zhao Y, Long H, Xie R, Zhu B
Stem cells (Dayton, Ohio) 2017 Feb;35(2):325-336
Stem cells (Dayton, Ohio) 2017 Feb;35(2):325-336
The inflammatory cytokine TNF-α promotes the premature senescence of rat nucleus pulposus cells via the PI3K/Akt signaling pathway.
Li P, Gan Y, Xu Y, Song L, Wang L, Ouyang B, Zhang C, Zhou Q
Scientific reports 2017 Feb 17;7:42938
Scientific reports 2017 Feb 17;7:42938
Anthocyanins Delay Ageing-Related Degenerative Changes in the Liver.
Wei J, Zhang G, Zhang X, Xu D, Gao J, Fan J
Plant foods for human nutrition (Dordrecht, Netherlands) 2017 Dec;72(4):425-431
Plant foods for human nutrition (Dordrecht, Netherlands) 2017 Dec;72(4):425-431
The inflammatory responses in Cu-mediated elemental imbalance is associated with mitochondrial fission and intrinsic apoptosis in Gallus gallus heart.
Li S, Zhao H, Wang Y, Shao Y, Li J, Liu J, Xing M
Chemosphere 2017 Dec;189:489-497
Chemosphere 2017 Dec;189:489-497
Co‑expression of murine double minute 2 siRNA and wild‑type p53 induces G1 cell cycle arrest in H1299 cells.
Liu L, Zhang P, Guo H, Tang X, Liu L, Li J, Guo R, Cai Y, Liu Y, Li Y
Molecular medicine reports 2017 Dec;16(6):9137-9142
Molecular medicine reports 2017 Dec;16(6):9137-9142
Phloretin induces apoptosis of human esophageal cancer via a mitochondria-dependent pathway.
Duan H, Wang R, Yan X, Liu H, Zhang Y, Mu D, Han J, Li X
Oncology letters 2017 Dec;14(6):6763-6768
Oncology letters 2017 Dec;14(6):6763-6768
Bisphenol AF negatively affects oocyte maturation of mouse in vitro through increasing oxidative stress and DNA damage.
Ding ZM, Jiao XF, Wu D, Zhang JY, Chen F, Wang YS, Huang CJ, Zhang SX, Li X, Huo LJ
Chemico-biological interactions 2017 Dec 25;278:222-229
Chemico-biological interactions 2017 Dec 25;278:222-229
Design, synthesis, and biological evaluation of hydantoin bridged analogues of combretastatin A-4 as potential anticancer agents.
Zhang M, Liang YR, Li H, Liu MM, Wang Y
Bioorganic & medicinal chemistry 2017 Dec 15;25(24):6623-6634
Bioorganic & medicinal chemistry 2017 Dec 15;25(24):6623-6634
IGFBP-rP1 acts as a potential tumor suppressor via the suppression of ERK signaling pathway in endometrial cancer cells.
Ma Y, Jiang J, Zhang Y, Ding Y, Xu T, Lu B
Molecular medicine reports 2017 Aug;16(2):1445-1450
Molecular medicine reports 2017 Aug;16(2):1445-1450
Anti-colon cancer effect of caffeic acid p-nitro-phenethyl ester in vitro and in vivo and detection of its metabolites.
Tang H, Yao X, Yao C, Zhao X, Zuo H, Li Z
Scientific reports 2017 Aug 8;7(1):7599
Scientific reports 2017 Aug 8;7(1):7599
Hsa-miR-513b-5p suppresses cell proliferation and promotes P53 expression by targeting IRF2 in testicular embryonal carcinoma cells.
Wang X, Zhang X, Wang G, Wang L, Lin Y, Sun F
Gene 2017 Aug 30;626:344-353
Gene 2017 Aug 30;626:344-353
Inflammatory factor TNF-α promotes the growth of breast cancer via the positive feedback loop of TNFR1/NF-κB (and/or p38)/p-STAT3/HBXIP/TNFR1.
Cai X, Cao C, Li J, Chen F, Zhang S, Liu B, Zhang W, Zhang X, Ye L
Oncotarget 2017 Aug 29;8(35):58338-58352
Oncotarget 2017 Aug 29;8(35):58338-58352
Role of Epithelial Cell Transforming Sequence 2 (ECT2) in Predicting Prognosis of Osteosarcoma.
Chen Z, Liu J, Zhang Y
Medical science monitor : international medical journal of experimental and clinical research 2017 Aug 10;23:3861-3868
Medical science monitor : international medical journal of experimental and clinical research 2017 Aug 10;23:3861-3868
Downregulation of B-myb promotes senescence via the ROS-mediated p53/p21 pathway, in vascular endothelial cells.
Zhou Z, Yin Y, Chang Q, Sun G, Lin J, Dai Y
Cell proliferation 2017 Apr;50(2)
Cell proliferation 2017 Apr;50(2)
Protective effect of naringin against the LPS-induced apoptosis of PC12 cells: Implications for the treatment of neurodegenerative disorders.
Wang H, Xu YS, Wang ML, Cheng C, Bian R, Yuan H, Wang Y, Guo T, Zhu LL, Zhou H
International journal of molecular medicine 2017 Apr;39(4):819-830
International journal of molecular medicine 2017 Apr;39(4):819-830
G protein subunit α q regulates gastric cancer growth via the p53/p21 and MEK/ERK pathways.
Wang Y, Xiao H, Wu H, Yao C, He H, Wang C, Li W
Oncology reports 2017 Apr;37(4):1998-2006
Oncology reports 2017 Apr;37(4):1998-2006
Nuclear retention of the lncRNA SNHG1 by doxorubicin attenuates hnRNPC-p53 protein interactions.
Shen Y, Liu S, Fan J, Jin Y, Tian B, Zheng X, Fu H
EMBO reports 2017 Apr;18(4):536-548
EMBO reports 2017 Apr;18(4):536-548
Boschniakia Rossica Polysaccharide Triggers Laryngeal Carcinoma Cell Apoptosis by Regulating Expression of Bcl-2, Caspase-3, and P53.
Yao C, Cao X, Fu Z, Tian J, Dong W, Xu J, An K, Zhai L, Yu J
Medical science monitor : international medical journal of experimental and clinical research 2017 Apr 29;23:2059-2064
Medical science monitor : international medical journal of experimental and clinical research 2017 Apr 29;23:2059-2064
Effects of selenium on the proliferation, apoptosis and testosterone production of sheep Leydig cells in vitro.
Shi L, Song R, Yao X, Ren Y
Theriogenology 2017 Apr 15;93:24-32
Theriogenology 2017 Apr 15;93:24-32
Identification, expression pattern and functional characterization of As-kip2 in diapause embryo restarting process of Artemia sinica.
Zhang M, Yao F, Qin T, Hou L, Zou X
Gene 2017 Apr 15;608:28-40
Gene 2017 Apr 15;608:28-40
Co-expression of ING4 and P53 enhances hypopharyngeal cancer chemosensitivity to cisplatin in vivo.
Ren X, Liu H, Zhang M, Wang M, Ma S
Molecular medicine reports 2016 Sep;14(3):2431-8
Molecular medicine reports 2016 Sep;14(3):2431-8
The Growth of SGC-7901 Tumor Xenografts Was Suppressed by Chinese Bayberry Anthocyanin Extract through Upregulating KLF6 Gene Expression.
Wang Y, Zhang XN, Xie WH, Zheng YX, Cao JP, Cao PR, Chen QJ, Li X, Sun CD
Nutrients 2016 Sep 27;8(10)
Nutrients 2016 Sep 27;8(10)
Novel Angiogenic Activity and Molecular Mechanisms of ZYZ-803, a Slow-Releasing Hydrogen Sulfide-Nitric Oxide Hybrid Molecule.
Hu Q, Wu D, Ma F, Yang S, Tan B, Xin H, Gu X, Chen X, Chen S, Mao Y, Zhu YZ
Antioxidants & redox signaling 2016 Sep 10;25(8):498-514
Antioxidants & redox signaling 2016 Sep 10;25(8):498-514
Lactobacillus rhamnosus induced epithelial cell apoptosis, ameliorates inflammation and prevents colon cancer development in an animal model.
Gamallat Y, Meyiah A, Kuugbee ED, Hago AM, Chiwala G, Awadasseid A, Bamba D, Zhang X, Shang X, Luo F, Xin Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 Oct;83:536-541
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 Oct;83:536-541
A novel strategy of profiling the mechanism of herbal medicines by combining network pharmacology with plasma concentration determination and affinity constant measurement.
Chen L, Lv D, Wang D, Chen X, Zhu Z, Cao Y, Chai Y
Molecular bioSystems 2016 Oct 18;12(11):3347-3356
Molecular bioSystems 2016 Oct 18;12(11):3347-3356
Age-associated up-regulation of EGR1 promotes granulosa cell apoptosis during follicle atresia in mice through the NF-κB pathway.
Yuan S, Wen J, Cheng J, Shen W, Zhou S, Yan W, Shen L, Luo A, Wang S
Cell cycle (Georgetown, Tex.) 2016 Nov;15(21):2895-2905
Cell cycle (Georgetown, Tex.) 2016 Nov;15(21):2895-2905
Overexpression of PKM2 promotes mitochondrial fusion through attenuated p53 stability.
Wu H, Yang P, Hu W, Wang Y, Lu Y, Zhang L, Fan Y, Xiao H, Li Z
Oncotarget 2016 Nov 22;7(47):78069-78082
Oncotarget 2016 Nov 22;7(47):78069-78082
Ziyuglycoside I Inhibits the Proliferation of MDA-MB-231 Breast Carcinoma Cells through Inducing p53-Mediated G2/M Cell Cycle Arrest and Intrinsic/Extrinsic Apoptosis.
Zhu X, Wang K, Zhang K, Zhang T, Yin Y, Xu F
International journal of molecular sciences 2016 Nov 22;17(11)
International journal of molecular sciences 2016 Nov 22;17(11)
Atrazine promotes RM1 prostate cancer cell proliferation by activating STAT3 signaling.
Hu K, Tian Y, Du Y, Huang L, Chen J, Li N, Liu W, Liang Z, Zhao L
International journal of oncology 2016 May;48(5):2166-74
International journal of oncology 2016 May;48(5):2166-74
Dioscin suppresses human laryngeal cancer cells growth via induction of cell-cycle arrest and MAPK-mediated mitochondrial-derived apoptosis and inhibition of tumor invasion.
Si L, Zheng L, Xu L, Yin L, Han X, Qi Y, Xu Y, Wang C, Peng J
European journal of pharmacology 2016 Mar 5;774:105-17
European journal of pharmacology 2016 Mar 5;774:105-17
Dioscin Induces Apoptosis in Human Cervical Carcinoma HeLa and SiHa Cells through ROS-Mediated DNA Damage and the Mitochondrial Signaling Pathway.
Zhao X, Tao X, Xu L, Yin L, Qi Y, Xu Y, Han X, Peng J
Molecules (Basel, Switzerland) 2016 Jun 4;21(6)
Molecules (Basel, Switzerland) 2016 Jun 4;21(6)
miR-34a-5p Inhibition Alleviates Intestinal Ischemia/Reperfusion-Induced Reactive Oxygen Species Accumulation and Apoptosis via Activation of SIRT1 Signaling.
Wang G, Yao J, Li Z, Zu G, Feng D, Shan W, Li Y, Hu Y, Zhao Y, Tian X
Antioxidants & redox signaling 2016 Jun 10;24(17):961-73
Antioxidants & redox signaling 2016 Jun 10;24(17):961-73
Upregulation of microRNA-22 contributes to myocardial ischemia-reperfusion injury by interfering with the mitochondrial function.
Du JK, Cong BH, Yu Q, Wang H, Wang L, Wang CN, Tang XL, Lu JQ, Zhu XY, Ni X
Free radical biology & medicine 2016 Jul;96:406-17
Free radical biology & medicine 2016 Jul;96:406-17
Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation.
Zhang W, Yin L, Tao X, Xu L, Zheng L, Han X, Xu Y, Wang C, Peng J
Environmental toxicology and pharmacology 2016 Jul;45:193-201
Environmental toxicology and pharmacology 2016 Jul;45:193-201
Expression and prognostic role of ubiquitination factor E4B in primary hepatocellular carcinoma.
Zhang XF, Pan QZ, Pan K, Weng DS, Wang QJ, Zhao JJ, He J, Liu Q, Wang DD, Jiang SS, Zheng HX, Lv L, Chen CL, Zhang HX, Xia JC
Molecular carcinogenesis 2016 Jan;55(1):64-76
Molecular carcinogenesis 2016 Jan;55(1):64-76
Expression of Hedgehog Signals and Growth Inhibition by Itraconazole in Endometrial Cancer.
Inoue K, Tsubamoto H, Sakata K, Sakane R, Hao H, Hirota S, Sonoda T, Shibahara H
Anticancer research 2016 Jan;36(1):149-53
Anticancer research 2016 Jan;36(1):149-53
Nogo-B receptor promotes the chemoresistance of human hepatocellular carcinoma via the ubiquitination of p53 protein.
Dong C, Zhao B, Long F, Liu Y, Liu Z, Li S, Yang X, Sun D, Wang H, Liu Q, Liang R, Li Y, Gao Z, Shao S, Miao QR, Wang L
Oncotarget 2016 Feb 23;7(8):8850-65
Oncotarget 2016 Feb 23;7(8):8850-65
Inhibitory effect of diosgenin on experimentally induced benign prostatic hyperplasia in rats.
Chen J, Zhang HF, Xiong CM, Ruan JL
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2016 Dec;36(6):806-810
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2016 Dec;36(6):806-810
H2O2 treatment or serum deprivation induces autophagy and apoptosis in naked mole-rat skin fibroblasts by inhibiting the PI3K/Akt signaling pathway.
Zhao S, Li L, Wang S, Yu C, Xiao B, Lin L, Cong W, Cheng J, Yang W, Sun W, Cui S
Oncotarget 2016 Dec 20;7(51):84839-84850
Oncotarget 2016 Dec 20;7(51):84839-84850
Unpredicted Downregulation of RAD51 Suggests Genome Instability Induced by Tetrachlorobenzoquinone.
Song X, Shi Q, Liu Z, Wang Y, Wang Y, Song E, Song Y
Chemical research in toxicology 2016 Dec 19;29(12):2184-2193
Chemical research in toxicology 2016 Dec 19;29(12):2184-2193
Combination of baicalein and 10-hydroxy camptothecin exerts remarkable synergetic anti-cancer effects.
Tang Q, Ji F, Sun W, Wang J, Guo J, Guo L, Li Y, Bao Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2016 Dec 15;23(14):1778-1786
Phytomedicine : international journal of phytotherapy and phytopharmacology 2016 Dec 15;23(14):1778-1786
Directional modification of chrysin for exerting apoptosis and enhancing significantly anti-cancer effects of 10-hydroxy camptothecin.
Tang Q, Ji F, Guo J, Wang J, Li Y, Bao Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 Aug;82:693-703
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2016 Aug;82:693-703
VNN1 promotes atherosclerosis progression in apoE-/- mice fed a high-fat/high-cholesterol diet.
Hu YW, Wu SG, Zhao JJ, Ma X, Lu JB, Xiu JC, Zhang Y, Huang C, Qiu YR, Sha YH, Gao JJ, Wang YC, Li SF, Zhao JY, Zheng L, Wang Q
Journal of lipid research 2016 Aug;57(8):1398-411
Journal of lipid research 2016 Aug;57(8):1398-411
Paper-based microreactor array for rapid screening of cell signaling cascades.
Huang CH, Lei KF, Tsang NM
Lab on a chip 2016 Aug 7;16(15):2911-20
Lab on a chip 2016 Aug 7;16(15):2911-20
Modulation of cyclins and p53 in mesangial cell proliferation and apoptosis during Habu nephritis.
Lu Y, Wen J, Chen D, Wu L, Li Q, Xie Y, Wu D, Liu X, Chen X
Clinical and experimental nephrology 2016 Apr;20(2):178-86
Clinical and experimental nephrology 2016 Apr;20(2):178-86
Bioinformatics analysis of proteomics profiles in senescent human primary proximal tubule epithelial cells.
Lu Y, Wang J, Dapeng C, Wu D, Cai G, Chen X
BMC nephrology 2016 Apr 1;17:39
BMC nephrology 2016 Apr 1;17:39
Disruption of human papillomavirus 16 E6 gene by clustered regularly interspaced short palindromic repeat/Cas system in human cervical cancer cells.
Yu L, Wang X, Zhu D, Ding W, Wang L, Zhang C, Jiang X, Shen H, Liao S, Ma D, Hu Z, Wang H
OncoTargets and therapy 2015;8:37-44
OncoTargets and therapy 2015;8:37-44
TRIM59 Promotes the Proliferation and Migration of Non-Small Cell Lung Cancer Cells by Upregulating Cell Cycle Related Proteins.
Zhan W, Han T, Zhang C, Xie C, Gan M, Deng K, Fu M, Wang JB
PloS one 2015;10(11):e0142596
PloS one 2015;10(11):e0142596
Elevated GAPDH expression is associated with the proliferation and invasion of lung and esophageal squamous cell carcinomas.
Hao L, Zhou X, Liu S, Sun M, Song Y, Du S, Sun B, Guo C, Gong L, Hu J, Guan H, Shao S
Proteomics 2015 Sep;15(17):3087-100
Proteomics 2015 Sep;15(17):3087-100
p53 is required for metformin-induced growth inhibition, senescence and apoptosis in breast cancer cells.
Li P, Zhao M, Parris AB, Feng X, Yang X
Biochemical and biophysical research communications 2015 Sep 4;464(4):1267-1274
Biochemical and biophysical research communications 2015 Sep 4;464(4):1267-1274
The oncoprotein HBXIP promotes glucose metabolism reprogramming via downregulating SCO2 and PDHA1 in breast cancer.
Liu F, Zhang W, You X, Liu Y, Li Y, Wang Z, Wang Y, Zhang X, Ye L
Oncotarget 2015 Sep 29;6(29):27199-213
Oncotarget 2015 Sep 29;6(29):27199-213
The oncoprotein HBXIP modulates the feedback loop of MDM2/p53 to enhance the growth of breast cancer.
Li H, Liu Q, Wang Z, Fang R, Shen Y, Cai X, Gao Y, Li Y, Zhang X, Ye L
The Journal of biological chemistry 2015 Sep 11;290(37):22649-61
The Journal of biological chemistry 2015 Sep 11;290(37):22649-61
Down-Regulated NRSN2 Promotes Cell Proliferation and Survival Through PI3K/Akt/mTOR Pathway in Hepatocellular Carcinoma.
Wang X, Han L, Zhang J, Xia Q
Digestive diseases and sciences 2015 Oct;60(10):3011-8
Digestive diseases and sciences 2015 Oct;60(10):3011-8
Protein kinase CK2α catalytic subunit is overexpressed and serves as an unfavorable prognostic marker in primary hepatocellular carcinoma.
Zhang HX, Jiang SS, Zhang XF, Zhou ZQ, Pan QZ, Chen CL, Zhao JJ, Tang Y, Xia JC, Weng DS
Oncotarget 2015 Oct 27;6(33):34800-17
Oncotarget 2015 Oct 27;6(33):34800-17
Olaquindox induces DNA damage via the lysosomal and mitochondrial pathway involving ROS production and p53 activation in HEK293 cells.
Yang Y, Jiang L, She Y, Chen M, Li Q, Yang G, Geng C, Tang L, Zhong L, Jiang L, Liu X
Environmental toxicology and pharmacology 2015 Nov;40(3):792-9
Environmental toxicology and pharmacology 2015 Nov;40(3):792-9
Pseudolaric acid B inhibits proliferation in SW579 human thyroid squamous cell carcinoma.
Yu J, Ren P, Zhong T, Wang Y, Yan M, Xue B, Li R, Dai C, Liu C, Chen G, Yu XF
Molecular medicine reports 2015 Nov;12(5):7195-202
Molecular medicine reports 2015 Nov;12(5):7195-202
Mucin 1 gene silencing inhibits the growth of SMMC-7721 human hepatoma cells through Bax-mediated mitochondrial and caspase-8-mediated death receptor apoptotic pathways.
Yuan H, Wang J, Wang F, Zhang N, Li Q, Xie F, Chen T, Zhai R, Wang F, Guo Y, Ni W, Tai G
Molecular medicine reports 2015 Nov;12(5):6782-8
Molecular medicine reports 2015 Nov;12(5):6782-8
A Critical Role for Cysteine 57 in the Biological Functions of Selenium Binding Protein-1.
Ying Q, Ansong E, Diamond AM, Yang W
International journal of molecular sciences 2015 Nov 18;16(11):27599-608
International journal of molecular sciences 2015 Nov 18;16(11):27599-608
Polychlorinated Biphenyl Quinone Metabolite Promotes p53-Dependent DNA Damage Checkpoint Activation, S-Phase Cycle Arrest and Extrinsic Apoptosis in Human Liver Hepatocellular Carcinoma HepG2 Cells.
Song X, Li L, Shi Q, Lehmler HJ, Fu J, Su C, Xia X, Song E, Song Y
Chemical research in toxicology 2015 Nov 16;28(11):2160-9
Chemical research in toxicology 2015 Nov 16;28(11):2160-9
RASSF10 suppresses hepatocellular carcinoma growth by activating P53 signaling and methylation of RASSF10 is a docetaxel resistant marker.
Jin Y, Cao B, Zhang M, Zhan Q, Herman JG, Yu M, Guo M
Genes & cancer 2015 May;6(5-6):231-40
Genes & cancer 2015 May;6(5-6):231-40
Synergistic anti-tumour effects of tetrandrine and chloroquine combination therapy in human cancer: a potential antagonistic role for p21.
Mei L, Chen Y, Wang Z, Wang J, Wan J, Yu C, Liu X, Li W
British journal of pharmacology 2015 May;172(9):2232-45
British journal of pharmacology 2015 May;172(9):2232-45
Deficiency of monoclonal non-specific suppressor factor beta (MNSFB) promotes pregnancy loss in mice.
Gu Y, He Y, Zhang X, Shi Y, Yang Q, Yu L, Sun Z, Zhang H, Wang J, Gao X, Wang J
Molecular reproduction and development 2015 Jun;82(6):475-88
Molecular reproduction and development 2015 Jun;82(6):475-88
5-Aminolevulinic Acid-Mediated Sonodynamic Therapy Promotes Phenotypic Switching from Dedifferentiated to Differentiated Phenotype via Reactive Oxygen Species and p38 Mitogen-Activated Protein Kinase in Vascular Smooth Muscle Cells.
Dan J, Sun X, Li W, Zhang Y, Li X, Xu H, Li Z, Tian Z, Guo S, Yao J, Gao W, Tian Y
Ultrasound in medicine & biology 2015 Jun;41(6):1681-9
Ultrasound in medicine & biology 2015 Jun;41(6):1681-9
Flotillin-2 promotes metastasis of nasopharyngeal carcinoma by activating NF-κB and PI3K/Akt3 signaling pathways.
Liu J, Huang W, Ren C, Wen Q, Liu W, Yang X, Wang L, Zhu B, Zeng L, Feng X, Zhang C, Chen H, Jia W, Zhang L, Xia X, Chen Y
Scientific reports 2015 Jul 24;5:11614
Scientific reports 2015 Jul 24;5:11614
Polychlorinated biphenyl quinone induces oxidative DNA damage and repair responses: The activations of NHEJ, BER and NER via ATM-p53 signaling axis.
Dong H, Shi Q, Song X, Fu J, Hu L, Xu D, Su C, Xia X, Song E, Song Y
Toxicology and applied pharmacology 2015 Jul 1;286(1):10-6
Toxicology and applied pharmacology 2015 Jul 1;286(1):10-6
Tetrandrine induces G1/S cell cycle arrest through the ROS/Akt pathway in EOMA cells and inhibits angiogenesis in vivo.
Xiao W, Jiang Y, Men Q, Yuan L, Huang Z, Liu T, Li W, Liu X
International journal of oncology 2015 Jan;46(1):360-8
International journal of oncology 2015 Jan;46(1):360-8
TALEN-mediated targeting of HPV oncogenes ameliorates HPV-related cervical malignancy.
Hu Z, Ding W, Zhu D, Yu L, Jiang X, Wang X, Zhang C, Wang L, Ji T, Liu D, He D, Xia X, Zhu T, Wei J, Wu P, Wang C, Xi L, Gao Q, Chen G, Liu R, Li K, Li S, Wang S, Zhou J, Ma D, Wang H
The Journal of clinical investigation 2015 Jan;125(1):425-36
The Journal of clinical investigation 2015 Jan;125(1):425-36
Enhanced anticancer activity of a protein phosphatase 2A inhibitor on chemotherapy and radiation in head and neck squamous cell carcinoma.
Zhu DW, Yuan YX, Qiao JK, Yu C, Yang X, Wang LZ, Zhang ZY, Zhong LP
Cancer letters 2015 Jan 28;356(2 Pt B):773-80
Cancer letters 2015 Jan 28;356(2 Pt B):773-80
Expression profile of apoptotic and proliferative proteins in hypoxic HUVEC treated with statins.
Li X, Liu X, Xu Y, He Y, Liu J, Xie M
International journal of oncology 2015 Feb;46(2):677-84
International journal of oncology 2015 Feb;46(2):677-84
RTEF-1 protects against oxidative damage induced by H2O2 in human umbilical vein endothelial cells through Klotho activation.
Sun S, Cheng B, Sun PG, Wu XH, Wu QQ, He P
Experimental biology and medicine (Maywood, N.J.) 2015 Dec;240(12):1606-13
Experimental biology and medicine (Maywood, N.J.) 2015 Dec;240(12):1606-13
5-Aminolevulinic acid-mediated sonodynamic therapy induces anti-tumor effects in malignant melanoma via p53-miR-34a-Sirt1 axis.
Hu Z, Fan H, Lv G, Zhou Q, Yang B, Zheng J, Cao W
Journal of dermatological science 2015 Aug;79(2):155-62
Journal of dermatological science 2015 Aug;79(2):155-62
HSF4 promotes G1/S arrest in human lens epithelial cells by stabilizing p53.
Huang M, Li D, Huang Y, Cui X, Liao S, Wang J, Liu F, Li C, Gao M, Chen J, Tang Z, Li DW, Liu M
Biochimica et biophysica acta 2015 Aug;1853(8):1808-17
Biochimica et biophysica acta 2015 Aug;1853(8):1808-17
The effect of mesenchymal stem cells on the p53 methylation in irradiation-induced thymoma in C57BL/6 mice.
Zheng HB, Fu YT, Pan ZX, Yang TW, Sun LH, Chen YB, Tong T
Journal of cancer research and therapeutics 2015 Apr-Jun;11(2):403-8
Journal of cancer research and therapeutics 2015 Apr-Jun;11(2):403-8
Identification of nestin as a urinary biomarker for acute kidney injury.
Zhang W, Zhang L, Chen YX, Xie YY, Zou YF, Zhang MJ, Gao YH, Liu Y, Zhao Q, Huang QH, Chen N
American journal of nephrology 2014;39(2):110-21
American journal of nephrology 2014;39(2):110-21
Dioscin attenuates hepatic ischemia-reperfusion injury in rats through inhibition of oxidative-nitrative stress, inflammation and apoptosis.
Tao X, Wan X, Xu Y, Xu L, Qi Y, Yin L, Han X, Lin Y, Peng J
Transplantation 2014 Sep 27;98(6):604-11
Transplantation 2014 Sep 27;98(6):604-11
Elevated p53 expression levels correlate with tumor progression and poor prognosis in patients exhibiting esophageal squamous cell carcinoma.
Huang K, Chen L, Zhang J, Wu Z, Lan L, Wang L, Lu B, Liu Y
Oncology letters 2014 Oct;8(4):1441-1446
Oncology letters 2014 Oct;8(4):1441-1446
Effects of the total saponins from Rosa laevigata Michx fruit against acetaminophen-induced liver damage in mice via induction of autophagy and suppression of inflammation and apoptosis.
Dong D, Xu L, Han X, Qi Y, Xu Y, Yin L, Liu K, Peng J
Molecules (Basel, Switzerland) 2014 May 30;19(6):7189-206
Molecules (Basel, Switzerland) 2014 May 30;19(6):7189-206
Protective effects of dioscin against alcohol-induced liver injury.
Xu T, Zheng L, Xu L, Yin L, Qi Y, Xu Y, Han X, Peng J
Archives of toxicology 2014 Mar;88(3):739-53
Archives of toxicology 2014 Mar;88(3):739-53
Cancer stem-like cell characteristics induced by EB virus-encoded LMP1 contribute to radioresistance in nasopharyngeal carcinoma by suppressing the p53-mediated apoptosis pathway.
Yang CF, Peng LX, Huang TJ, Yang GD, Chu QQ, Liang YY, Cao X, Xie P, Zheng LS, Huang HB, Cai MD, Huang JL, Liu RY, Zhu ZY, Qian CN, Huang BJ
Cancer letters 2014 Mar 28;344(2):260-71
Cancer letters 2014 Mar 28;344(2):260-71
Probing the cell death signaling pathway of HepG2 cell line induced by copper-1,10-phenanthroline complex.
Wu J, Chen W, Yin Y, Zheng Z, Zou G
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2014 Jun;27(3):445-58
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 2014 Jun;27(3):445-58
Downregulated protein O-fucosyl transferase 1 (Pofut1) expression exerts antiproliferative and antiadhesive effects on hepatocytes by inhibiting Notch signalling.
Annani-Akollor ME, Wang S, Fan J, Liu L, Padhiar AA, Zhang J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2014 Jul;68(6):785-90
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2014 Jul;68(6):785-90
DDX3X regulates cell survival and cell cycle during mouse early embryonic development.
Li Q, Zhang P, Zhang C, Wang Y, Wan R, Yang Y, Guo X, Huo R, Lin M, Zhou Z, Sha J
Journal of biomedical research 2014 Jul;28(4):282-91
Journal of biomedical research 2014 Jul;28(4):282-91
MiR-135a functions as a tumor suppressor in epithelial ovarian cancer and regulates HOXA10 expression.
Tang W, Jiang Y, Mu X, Xu L, Cheng W, Wang X
Cellular signalling 2014 Jul;26(7):1420-6
Cellular signalling 2014 Jul;26(7):1420-6
TET1 exerts its tumor suppressor function by interacting with p53-EZH2 pathway in gastric cancer.
Fu HL, Ma Y, Lu LG, Hou P, Li BJ, Jin WL, Cui DX
Journal of biomedical nanotechnology 2014 Jul;10(7):1217-30
Journal of biomedical nanotechnology 2014 Jul;10(7):1217-30
Bisphenol A induces oxidative stress-associated DNA damage in INS-1 cells.
Xin F, Jiang L, Liu X, Geng C, Wang W, Zhong L, Yang G, Chen M
Mutation research. Genetic toxicology and environmental mutagenesis 2014 Jul 15;769:29-33
Mutation research. Genetic toxicology and environmental mutagenesis 2014 Jul 15;769:29-33
Salvianolic acid B protects against acute ethanol-induced liver injury through SIRT1-mediated deacetylation of p53 in rats.
Li M, Lu Y, Hu Y, Zhai X, Xu W, Jing H, Tian X, Lin Y, Gao D, Yao J
Toxicology letters 2014 Jul 15;228(2):67-74
Toxicology letters 2014 Jul 15;228(2):67-74
Interplay between the Notch and PI3K/Akt pathways in high glucose-induced podocyte apoptosis.
Wang XM, Yao M, Liu SX, Hao J, Liu QJ, Gao F
American journal of physiology. Renal physiology 2014 Jan;306(2):F205-13
American journal of physiology. Renal physiology 2014 Jan;306(2):F205-13
Potent effects of flavonoid-rich extract from Rosa laevigata Michx fruit against hydrogen peroxide-induced damage in PC12 cells via attenuation of oxidative stress, inflammation and apoptosis.
Liu M, Xu Y, Han X, Liang C, Yin L, Xu L, Qi Y, Zhao Y, Peng J, Sun C
Molecules (Basel, Switzerland) 2014 Aug 7;19(8):11816-32
Molecules (Basel, Switzerland) 2014 Aug 7;19(8):11816-32
Differential effects of p53 on bystander phenotypes induced by gamma ray and high LET heavy ion radiation.
He M, Dong C, Konishi T, Tu W, Liu W, Shiomi N, Kobayashi A, Uchihori Y, Furusawa Y, Hei TK, Dang B, Shao C
Life sciences in space research 2014 Apr;1:53-9
Life sciences in space research 2014 Apr;1:53-9
Protective effect of SIRT1 on toxicity of microglial-derived factors induced by LPS to PC12 cells via the p53-caspase-3-dependent apoptotic pathway.
Ye J, Liu Z, Wei J, Lu L, Huang Y, Luo L, Xie H
Neuroscience letters 2013 Oct 11;553:72-7
Neuroscience letters 2013 Oct 11;553:72-7
Protective effect of flavonoid-rich extract from Rosa laevigata Michx on cerebral ischemia-reperfusion injury through suppression of apoptosis and inflammation.
Zhang S, Qi Y, Xu Y, Han X, Peng J, Liu K, Sun CK
Neurochemistry international 2013 Nov;63(5):522-32
Neurochemistry international 2013 Nov;63(5):522-32
Notch pathway is involved in high glucose-induced apoptosis in podocytes via Bcl-2 and p53 pathways.
Gao F, Yao M, Shi Y, Hao J, Ren Y, Liu Q, Wang X, Duan H
Journal of cellular biochemistry 2013 May;114(5):1029-38
Journal of cellular biochemistry 2013 May;114(5):1029-38
Loss of microRNA-143/145 disturbs cellular growth and apoptosis of human epithelial cancers by impairing the MDM2-p53 feedback loop.
Zhang J, Sun Q, Zhang Z, Ge S, Han ZG, Chen WT
Oncogene 2013 Jan 3;32(1):61-9
Oncogene 2013 Jan 3;32(1):61-9
Protective effects of the total saponins from Rosa laevigata Michx fruit against carbon tetrachloride-induced acute liver injury in mice.
Dong D, Zhang S, Yin L, Tang X, Xu Y, Han X, Qi Y, Peng J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2013 Dec;62:120-30
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2013 Dec;62:120-30
High level of COP1 expression is associated with poor prognosis in primary gastric cancer.
Li YF, Wang DD, Zhao BW, Wang W, Huang CY, Chen YM, Zheng Y, Keshari RP, Xia JC, Zhou ZW
International journal of biological sciences 2012;8(8):1168-77
International journal of biological sciences 2012;8(8):1168-77
Alantolactone induces activation of apoptosis in human hepatoma cells.
Lei JC, Yu JQ, Yin Y, Liu YW, Zou GL
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2012 Sep;50(9):3313-9
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2012 Sep;50(9):3313-9
Total flavonoids from Rosa Laevigata Michx fruit attenuates hydrogen peroxide induced injury in human umbilical vein endothelial cells.
Jia Y, Ji L, Zhang S, Xu L, Yin L, Li L, Zhao Y, Peng J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2012 Sep;50(9):3133-41
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2012 Sep;50(9):3133-41
Sensitive detection of intracellular sumoylation via SNAP tag-mediated translation and RNA polymerase-based amplification.
Yang Y, Zhang CY
Analytical chemistry 2012 Feb 7;84(3):1229-34
Analytical chemistry 2012 Feb 7;84(3):1229-34
NF-κB, JNK and p53 pathways are involved in tubeimoside-1-induced apoptosis in HepG2 cells with oxidative stress and G₂/M cell cycle arrest.
Yin Y, Chen W, Tang C, Ding H, Jang J, Weng M, Cai Y, Zou G
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2011 Dec;49(12):3046-54
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2011 Dec;49(12):3046-54
Induction of apoptosis in hepatocellular carcinoma Smmc-7721 cells by vitamin K(2) is associated with p53 and independent of the intrinsic apoptotic pathway.
Li L, Qi Z, Qian J, Bi F, Lv J, Xu L, Zhang L, Chen H, Jia R
Molecular and cellular biochemistry 2010 Sep;342(1-2):125-31
Molecular and cellular biochemistry 2010 Sep;342(1-2):125-31
alpha-Bisabolol induces dose- and time-dependent apoptosis in HepG2 cells via a Fas- and mitochondrial-related pathway, involves p53 and NFkappaB.
Chen W, Hou J, Yin Y, Jang J, Zheng Z, Fan H, Zou G
Biochemical pharmacology 2010 Jul 15;80(2):247-54
Biochemical pharmacology 2010 Jul 15;80(2):247-54
MiR-145, a new regulator of the DNA fragmentation factor-45 (DFF45)-mediated apoptotic network.
Zhang J, Guo H, Qian G, Ge S, Ji H, Hu X, Chen W
Molecular cancer 2010 Aug 6;9:211
Molecular cancer 2010 Aug 6;9:211
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- MCF7 cells were subjected to SDS PAGE followed by western blot with 10442-1-AP(P53 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-P53 (IP:10442-1-AP, 4ug; Detection:10442-1-AP 1:1000) with A431 cells lysate 3000ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human endometrial cancer using 10442-1-AP(P53 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The P53 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human P53. This antibody recognizes human, rat, mouse antigen. The P53 antibody has been validated for the following applications: ELISA, IHC, IP, WB analysis.
