ABIN2452068

antibody from antibodies-online

Targeting: TP53 LFS1, p53

Western blot (Data presented on provider website)

ELISA (Recommended by provider)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

ABIN2452068

Provider

antibodies-online

Product name

anti-Tumor Protein P53 (TP53) (pSer46) antibody

Antibody type

Monoclonal

Antigen

Synthetic peptide containing pSer46 of p53

Description

Purified from serum-free culture medium of hybridoma (#36) by proprietary chromatography procedures under mild conditions.

Reactivity

Human

Host

Mouse

Epitope

pSer46

Isotype

IgG

Antibody clone number

#36

Vial size

50 μg

Storage

Upon arrival centrifuge briefly and store at -20 C.

References

Submitted references

ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage.

Taira N, Yamamoto H, Yamaguchi T, Miki Y, Yoshida K
The Journal of biological chemistry 2010 Feb 12;285(7):4909-19

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Requirement of ATM for rapid p53 phosphorylation at Ser46 without Ser/Thr-Gln sequences.

Kodama M, Otsubo C, Hirota T, Yokota J, Enari M, Taya Y
Molecular and cellular biology 2010 Apr;30(7):1620-33

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DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage.

Taira N, Nihira K, Yamaguchi T, Miki Y, Yoshida K
Molecular cell 2007 Mar 9;25(5):725-38