Antibody data
- Antibody Data
- Antigen structure
- References [5]
- Comments [0]
- Validations [0]
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- Product number
- ABIN196789 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Tumor Protein P53 (TP53) (pSer315) antibody
- Antibody type
- Polyclonal
- Description
- Affinity Chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
- Reactivity
- Human
- Host
- Rabbit
- Epitope
- pSer315
- Vial size
- 50 μL
- Storage
- Store the antibody (in aliquots) at -20°C.
- Handling
- Avoid repeated freezing and thawing.
Submitted references Activation of the DNA-binding ability of latent p53 protein by protein kinase C is abolished by protein kinase CK2.
Site-specific phosphorylation of human p53 protein determined by mass spectrometry.
The CDK7-cycH-p36 complex of transcription factor IIH phosphorylates p53, enhancing its sequence-specific DNA binding activity in vitro.
Differential effects of phosphorylation of rat p53 on transactivation of promoters derived from different p53 responsive genes.
Phosphorylation at Ser-15 and Ser-392 in mutant p53 molecules from human tumors is altered compared to wild-type p53.
Pospísilová S, Brázda V, Kucharíková K, Luciani MG, Hupp TR, Skládal P, Palecek E, Vojtesek B
The Biochemical journal 2004 Mar 15;378(Pt 3):939-47
The Biochemical journal 2004 Mar 15;378(Pt 3):939-47
Site-specific phosphorylation of human p53 protein determined by mass spectrometry.
Merrick BA, Zhou W, Martin KJ, Jeyarajah S, Parker CE, Selkirk JK, Tomer KB, Borchers CH
Biochemistry 2001 Apr 3;40(13):4053-66
Biochemistry 2001 Apr 3;40(13):4053-66
The CDK7-cycH-p36 complex of transcription factor IIH phosphorylates p53, enhancing its sequence-specific DNA binding activity in vitro.
Lu H, Fisher RP, Bailey P, Levine AJ
Molecular and cellular biology 1997 Oct;17(10):5923-34
Molecular and cellular biology 1997 Oct;17(10):5923-34
Differential effects of phosphorylation of rat p53 on transactivation of promoters derived from different p53 responsive genes.
Lohrum M, Scheidtmann KH
Oncogene 1996 Dec 19;13(12):2527-39
Oncogene 1996 Dec 19;13(12):2527-39
Phosphorylation at Ser-15 and Ser-392 in mutant p53 molecules from human tumors is altered compared to wild-type p53.
Ullrich SJ, Sakaguchi K, Lees-Miller SP, Fiscella M, Mercer WE, Anderson CW, Appella E
Proceedings of the National Academy of Sciences of the United States of America 1993 Jul 1;90(13):5954-8
Proceedings of the National Academy of Sciences of the United States of America 1993 Jul 1;90(13):5954-8
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