ABIN196787

antibody from antibodies-online

Targeting: TP53 LFS1, p53

Western blot (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Antibody Data

Product number

ABIN196787

Provider

antibodies-online

Product name

anti-Tumor Protein P53 (TP53) (pSer46) antibody

Antibody type

Polyclonal

Description

Affinity Chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.

Reactivity

Human

Host

Rabbit

Epitope

pSer46

Vial size

50 μL

Storage

Store the antibody (in aliquots) at -20°C.

Handling

Avoid repeated freezing and thawing.

References

Submitted references

Phosphorylation of human p53 at serine 46 determines promoter selection and whether apoptosis is attenuated or amplified.

Mayo LD, Seo YR, Jackson MW, Smith ML, Rivera Guzman J, Korgaonkar CK, Donner DB
The Journal of biological chemistry 2005 Jul 15;280(28):25953-9

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HIPK2 contributes to PCAF-mediated p53 acetylation and selective transactivation of p21Waf1 after nonapoptotic DNA damage.

Di Stefano V, Soddu S, Sacchi A, D'Orazi G
Oncogene 2005 Aug 18;24(35):5431-42

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A decade of CDK5.

Dhavan R, Tsai LH
Nature reviews. Molecular cell biology 2001 Oct;2(10):749-59

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p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway.

Patrick GN, Zhou P, Kwon YT, Howley PM, Tsai LH
The Journal of biological chemistry 1998 Sep 11;273(37):24057-64