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- Antibody Data
- Antigen structure
- References [81]
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- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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- Product number
- 21891-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#21891-1-AP, RRID:AB_10896826
- Product name
- P53 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated P53 antibody (Cat. #21891-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Deciphering functional intra-tumoral heterogeneity in BRAF(V600E)-driven mouse thyroid cancer reveals EMT trajectory and metabolic remodeling.
Inflammation Affects the Osteogenic Differentiation of Aged Periodontal Ligament Cells via NF-κB/FOXO3a/c-JUN Signalling.
cGAS-STING/HMGB1-mediated senescence induced by LRRK2 accelerates cartilage degeneration in osteoarthritis.
APR-246 drives ROS-dependent ferroptosis and apoptosis and enhances anti-PD-1 efficacy in bladder cancer.
Zuogui pill ameliorates DNA damage and the senescence-associated secretory phenotype in ovarian stem cells to delay ovarian ageing through activation of SIRT1.
Discovery of frailty-linked proteins through multi-omics integration of brain and plasma proteomes with GWAS datasets.
Ubiquitin ligase Nedd4 regulates the abundance and toxicity of mutant huntingtin.
Danshensu Ethyl Ester Induces Ferroptosis Through Targeted Inhibition of SLC7A11 Transport Function in NSCLC.
Uncovering the mechanism of resveratrol in the treatment of asthma: a network pharmacology approach with molecular docking and experimental validation.
Roxadustat regulates the cell cycle and inhibits proliferation of mesangial cells via the hypoxia-inducible factor-1α/P53/P21 pathway.
The PIWI-interacting RNA CRAPIR alleviates myocardial ischemia‒reperfusion injury by reducing p53-mediated apoptosis via binding to SRSF1.
Pharmacological role of MLN4924 in cisplatin-induced acute kidney injury.
Hypoxic Natural Killer Cells-Derived HIF-1α-Containing Exosomes Inhibit Cellular Senescence and Apoptosis in Neurocytes to Ameliorate Alzheimer's Disease by Eliminating Oxidative Damages.
Fluoride-induced vascular endothelial injury and the protective mechanism of blueberry anthocyanins.
Glycyrrhetinic acid functionalized polyamidoamine dendrimers for targeted gene delivery in liver cancer.
LINC01140/miR-200c-3p and LINC01550/miR-363-3p networks play pivotal role in orchestrating progression of endometriosis†.
ISRIB facilitates post-spinal cord injury recovery through attenuation of neuronal apoptosis and modulation of neuroinflammation.
HIV Vpr activates a nucleolar-specific ATR pathway to degrade the nucleolar stress sensor CCDC137.
Role of the SPI1/CDKN2A/p53 signaling pathway in cuproptosis of lung adenocarcinoma cells.
Xiyangshen Sanqi Danshen granules attenuated D-gal-induced C57BL/6J mouse aging through the AMPK/SIRT1 signaling pathway.
GNF-5837 alleviates intervertebral disc ageing by upregulating glutathione peroxidase 7.
Annona muricata Graviola Induces Apoptosis in Two Osteosarcoma Cell Lines and Downregulates the Cytokines IL-6 and TGFβ1 Which Are Implicated in Tumour Growth and Metastasis.
Lactamase β reprograms lipid metabolism to inhibit the progression of endometrial cancer through attenuating MDM2-mediated p53 ubiquitination and degradation.
Quercetin alleviates ethanol-induced hepatocyte senescence by interacting with glycinamide ribonucleotide transformylase.
Targeting and Suppression of Survivin in Cancer Cells Based on the Interaction of Cell Surface Vimentin with N‑Acetylglucosamine-Bearing Polymers.
USP15 Facilitates Colorectal Cancer Immune Evasion through SMYD3/CCL2-Dependent Myeloid-Derived Suppressor Cell Recruitment.
DNA methyltransferase DNMT3A inhibits TP53AIP1 expression and promotes cervical cancer development and metastasis.
Dasatinib demonstrates efficacy in organoid derived paclitaxel-resistant Trp53/Cdh1-deficient mouse gastric adenocarcinoma with peritoneal metastasis.
Novel mechanism of fluoride induced cardiovascular system injury by regulating p53/miR200c-3p during endothelial dysfunction.
Mechanism of baicalein in treatment of castration-resistant prostate cancer based on network pharmacology and cell experiments.
Harmine inhibits pulmonary fibrosis through regulating DNA damage repair-related genes and activation of TP53-Gadd45α pathway.
Trimethylamine-N-oxide aggravated the sympathetic excitation in D-galactose induced aging rats by down-regulating P2Y12 receptor in microglia.
Cryptochrome 1 regulates ovarian granulosa cell senescence through NCOA4-mediated ferritinophagy.
Novel insights into gut health: Cilostazol strengthens gut integrity by adjusting TLR-2/NF-κB/IL-23 and CD44/AKT/GSK-3β/cyclin-D1 trajectories in methotrexate-induced mucositis model.
Lipid-like gemcitabine diester-loaded liposomes for improved chemotherapy of pancreatic cancer.
Shenqu xiaoshi oral solution enhances digestive function and stabilizes the gastrointestinal microbiota of juvenile rats with infantile anorexia.
RNA-binding protein HNRNPD promotes chondrocyte senescence and osteoarthritis progression through upregulating FOXM1.
Curcumin suppresses colorectal cancer by induction of ferroptosis via regulation of p53 and solute carrier family 7 member 11/glutathione/glutathione peroxidase 4 signaling axis.
Polystyrene nanoplastics induce cardiotoxicity by upregulating HIPK2 and activating the P53 and TGF-β1/Smad3 pathways.
In vitro study of HPV18-positive cervical cancer HeLa cells based on CRISPR/Cas13a system.
Targeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome.
PM2.5 exposure-induced senescence-associated secretory phenotype in airway smooth muscle cells contributes to airway remodeling.
The zinc figure protein ZNF575 impairs colorectal cancer growth via promoting p53 transcription.
Mechanism of the HIF-1α/VEGF/VEGFR-2 pathway in the proliferation and apoptosis of human haemangioma endothelial cells.
The significance of CDT1 expression in non-cancerous and cancerous liver in cases with hepatocellular carcinoma.
One Stone, Two Birds: A Peptide-Au(I) Infinite Coordination Supermolecule for the Confederate Physical and Biological Radiosensitization in Cancer Radiation Therapy.
Changes in calpain-2 expression during glioblastoma progression predisposes tumor cells to temozolomide resistance by minimizing DNA damage and p53-dependent apoptosis.
UBE2T promotes glioblastoma malignancy through ubiquitination-mediated degradation of RPL6.
A p53-TLR3 axis ameliorates pulmonary hypertension by inducing BMPR2 via IRF3.
Hydrogen Sulfide Inhibited Sympathetic Activation in D-Galactose-Induced Aging Rats by Upregulating Klotho and Inhibiting Inflammation in the Paraventricular Nucleus.
Baicalein attenuates bleomycin-induced lung fibroblast senescence and lung fibrosis through restoration of Sirt3 expression.
Dimethyl Bisphenolate Ameliorates Carbon Tetrachloride-Induced Liver Injury by Regulating Oxidative Stress-Related Genes.
Aquaporin 1 Facilitates Ferroptosis, M1 Polarization, Mitochondrial Dysfunction, and Autophagy Damage on Lipopolysaccharide-Induced Macrophage Through Down-Regulation of P53 Signaling Pathway.
Recombinant human p53 adenovirus injection combined with Bortezomib inhibits proliferation and promotes apoptosis in multiple myeloma.
Peritoneal M2 macrophage-derived extracellular vesicles as natural multitarget nanotherapeutics to attenuate cytokine storms after severe infections.
Circadian clock gene BMAL1 inhibits the proliferation and tumor-formation ability of nasopharyngeal carcinoma cells and increases the sensitivity of radiotherapy.
Ginseng under forest exerts stronger anti-aging effects compared to garden ginseng probably via regulating PI3K/AKT/mTOR pathway, SIRT1/NF-κB pathway and intestinal flora.
The miRNA-34a/Sirt1/p53 pathway in a rat model of lens regeneration.
COVID-19 lung disease shares driver AT2 cytopathic features with Idiopathic pulmonary fibrosis.
Choline-induced SLC5A7 impairs colorectal cancer growth by stabilizing p53 protein.
The Role of RAD6B and PEDF in Retinal Degeneration.
MiR-4521 plays a tumor repressive role in growth and metastasis of hepatocarcinoma cells by suppressing phosphorylation of FAK/AKT pathway via targeting FAM129A.
Interfering with mitochondrial dynamics sensitizes glioblastoma multiforme to temozolomide chemotherapy.
Tryptophan-sorbitol based carbon quantum dots for theranostics against hepatocellular carcinoma.
Efficient reprogramming of human fibroblasts using RNA reprogramming with DAPT and iDOT1L under normoxia conditions.
Critical Role of Cathepsin L/V in Regulating Endothelial Cell Senescence.
Aerobic glycolysis and tumor progression of hepatocellular carcinoma are mediated by ubiquitin of P53 K48-linked regulated by TRIM37.
COVID-19 lung disease shares driver AT2 cytopathic features with Idiopathic pulmonary fibrosis.
Identification of distinct genomic features reveals frequent somatic AHNAK and PTEN mutations predominantly in primary malignant melanoma presenting in the ureter.
PIN1 Protects Hair Cells and Auditory HEI-OC1 Cells against Senescence by Inhibiting the PI3K/Akt/mTOR Pathway.
Pathologic role of peptidyl-prolyl isomerase Pin1 in pulmonary artery remodeling.
Arsenic sulfide reverses cisplatin resistance in non-small cell lung cancer in vitro and in vivo through targeting PD-L1.
Th17/IL-17 induces endothelial cell senescence via activation of NF-κB/p53/Rb signaling pathway.
Extracellular vesicles derived from hypoxia-preconditioned olfactory mucosa mesenchymal stem cells enhance angiogenesis via miR-612.
The intracellular domain of UNC5B facilities proliferation and metastasis of bladder cancer cells.
P53 Activated by ER Stress Aggravates Caerulein-Induced Acute Pancreatitis Progression by Inducing Acinar Cell Apoptosis.
UNC5B mediates G2/M phase arrest of bladder cancer cells by binding to CDC14A and P53.
LINC00460-miR-149-5p/miR-150-5p-Mutant p53 Feedback Loop Promotes Oxaliplatin Resistance in Colorectal Cancer.
A pilot study comparing the genetic molecular biology of gestational and non-gestational choriocarcinoma.
p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors.
NKD1 correlates with a poor prognosis and inhibits cell proliferation by inducing p53 expression in hepatocellular carcinoma.
Yu J, Shen S, Luo R, Qiu T, Chen J, Kong W, Ma R, Yan Y, Niu Z, Ma M, Li Z, Wu Y, Li Y, Zhang L, Ying H
Oncogene 2026 May;45(18):1660-1674
Oncogene 2026 May;45(18):1660-1674
Inflammation Affects the Osteogenic Differentiation of Aged Periodontal Ligament Cells via NF-κB/FOXO3a/c-JUN Signalling.
Zhu L, Tang Z, Hu R, Li Y, Li X, Gu M, Yang Y
Journal of periodontal research 2026 Mar;61(3):292-308
Journal of periodontal research 2026 Mar;61(3):292-308
cGAS-STING/HMGB1-mediated senescence induced by LRRK2 accelerates cartilage degeneration in osteoarthritis.
Zhang Y, Zhu Z, Ji P, Ming J, Zhou Y
Cell death & disease 2026 Mar 25;17(1)
Cell death & disease 2026 Mar 25;17(1)
APR-246 drives ROS-dependent ferroptosis and apoptosis and enhances anti-PD-1 efficacy in bladder cancer.
Zhang C, Cao S, Zeng G, Dong Y, Li H, Ma X, Zhang X, Li Z, Huang Y
Scientific reports 2026 Mar 15;16(1)
Scientific reports 2026 Mar 15;16(1)
Zuogui pill ameliorates DNA damage and the senescence-associated secretory phenotype in ovarian stem cells to delay ovarian ageing through activation of SIRT1.
Wang YX, Zhang YS, Liu X, An JY, Li GY, Zou YX, Zheng YL, Fang Y, Li KX, Zhu L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158114
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158114
Discovery of frailty-linked proteins through multi-omics integration of brain and plasma proteomes with GWAS datasets.
Zhong J, Yuan M, Zhou E, Hu S
Experimental gerontology 2026 Jun 1;218:113120
Experimental gerontology 2026 Jun 1;218:113120
Ubiquitin ligase Nedd4 regulates the abundance and toxicity of mutant huntingtin.
Jeong H, Qin Y, Xu F, Trajkovic K, Kim MJ, Marotta N, Hamada K, Allada R, Yang S, Krainc D
JCI insight 2026 Feb 23;11(4)
JCI insight 2026 Feb 23;11(4)
Danshensu Ethyl Ester Induces Ferroptosis Through Targeted Inhibition of SLC7A11 Transport Function in NSCLC.
Yan R, Xu S, Yan M, Wu D, Zhang J, Zhang C, Liu J, Li YJ, Feng J, Qu GW, Xie SY
Thoracic cancer 2026 Apr;17(8):e70283
Thoracic cancer 2026 Apr;17(8):e70283
Uncovering the mechanism of resveratrol in the treatment of asthma: a network pharmacology approach with molecular docking and experimental validation.
Chunxiao L, Xin H, Bowen L, Bingqing S, Mengqi Z, Shuwen Z, Jingyuan Z, Jiangtao L
Frontiers in pharmacology 2025;16:1596737
Frontiers in pharmacology 2025;16:1596737
Roxadustat regulates the cell cycle and inhibits proliferation of mesangial cells via the hypoxia-inducible factor-1α/P53/P21 pathway.
Cheng Y, Yang Q, Feng B, Yang X, Jin H
Frontiers in cell and developmental biology 2025;13:1503477
Frontiers in cell and developmental biology 2025;13:1503477
The PIWI-interacting RNA CRAPIR alleviates myocardial ischemia‒reperfusion injury by reducing p53-mediated apoptosis via binding to SRSF1.
Yan H, Li H, Yin DH, Zhang ZZ, Zhang QY, Ren ZY, Hu Y, Zheng GY, Liu Y, Ma WY, Liu YN, Wang XX, Cai BZ, Chen HY
Acta pharmacologica Sinica 2025 Sep;46(9):2393-2406
Acta pharmacologica Sinica 2025 Sep;46(9):2393-2406
Pharmacological role of MLN4924 in cisplatin-induced acute kidney injury.
Chen F, Yusufu A, Li G, Gao X, Lu D, Wu X, Ni L
Biochimica et biophysica acta. General subjects 2025 Sep;1869(10):130842
Biochimica et biophysica acta. General subjects 2025 Sep;1869(10):130842
Hypoxic Natural Killer Cells-Derived HIF-1α-Containing Exosomes Inhibit Cellular Senescence and Apoptosis in Neurocytes to Ameliorate Alzheimer's Disease by Eliminating Oxidative Damages.
Zhou Y, Rong Y
Molecular neurobiology 2025 Oct;62(10):13089-13102
Molecular neurobiology 2025 Oct;62(10):13089-13102
Fluoride-induced vascular endothelial injury and the protective mechanism of blueberry anthocyanins.
Zhang C, Wang Y, Huang F, Zhang Y, Huang M, Liu Y, Angwa L, Gao Y, Sun D, Jiang Y
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Oct;204:115665
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Oct;204:115665
Glycyrrhetinic acid functionalized polyamidoamine dendrimers for targeted gene delivery in liver cancer.
Wang M, Sang Y, Qin X, Ji L, Wang H, Yu R, Jin T, Lu Y, Cong Y, Shi B
Biomaterials science 2025 Oct 7;13(20):5786-5800
Biomaterials science 2025 Oct 7;13(20):5786-5800
LINC01140/miR-200c-3p and LINC01550/miR-363-3p networks play pivotal role in orchestrating progression of endometriosis†.
Huang Y, Zhang D, Zhou Y, Peng C
Biology of reproduction 2025 Nov 14;113(5):1237-1253
Biology of reproduction 2025 Nov 14;113(5):1237-1253
ISRIB facilitates post-spinal cord injury recovery through attenuation of neuronal apoptosis and modulation of neuroinflammation.
Li Q, Zhang C, Qi E, Wu M, Sun H, Zhang T, Jiang Y, Li H, Jiang R, Li C, Zhao H, Zhou H, Feng S
Journal of orthopaedic translation 2025 Mar;51:119-131
Journal of orthopaedic translation 2025 Mar;51:119-131
HIV Vpr activates a nucleolar-specific ATR pathway to degrade the nucleolar stress sensor CCDC137.
Nisson KA, Patel RS, Delgado Y, Bouhaddou M, Etienne L, Fregoso OI
Nucleic acids research 2025 Jun 6;53(11)
Nucleic acids research 2025 Jun 6;53(11)
Role of the SPI1/CDKN2A/p53 signaling pathway in cuproptosis of lung adenocarcinoma cells.
An J, Song W, Wang Q, Tan B, Fei X, Wang R, Li S, Lu X, Li Y, Xie N
Oncology letters 2025 Jul;30(1):353
Oncology letters 2025 Jul;30(1):353
Xiyangshen Sanqi Danshen granules attenuated D-gal-induced C57BL/6J mouse aging through the AMPK/SIRT1 signaling pathway.
Yin Z, Tian L, Kou W, Cao G, Wang L, Xia Y, Lin Y, Tang S, Zhang J, Yang H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156213
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156213
GNF-5837 alleviates intervertebral disc ageing by upregulating glutathione peroxidase 7.
Xu Y, Chen R, Zhuang Y, Xu W
International journal of immunopathology and pharmacology 2025 Jan-Dec;39:3946320251343365
International journal of immunopathology and pharmacology 2025 Jan-Dec;39:3946320251343365
Annona muricata Graviola Induces Apoptosis in Two Osteosarcoma Cell Lines and Downregulates the Cytokines IL-6 and TGFβ1 Which Are Implicated in Tumour Growth and Metastasis.
Yagnik D, Neergheen V, Grant C, Shah AJ
Integrative cancer therapies 2025 Jan-Dec;24:15347354251360338
Integrative cancer therapies 2025 Jan-Dec;24:15347354251360338
Lactamase β reprograms lipid metabolism to inhibit the progression of endometrial cancer through attenuating MDM2-mediated p53 ubiquitination and degradation.
Zhou T, Li X, Zhao F, Zhou J, Sun B
Archives of biochemistry and biophysics 2025 Feb;764:110287
Archives of biochemistry and biophysics 2025 Feb;764:110287
Quercetin alleviates ethanol-induced hepatocyte senescence by interacting with glycinamide ribonucleotide transformylase.
Huimin C, Shufen P, Zhaoyu C, Jiaxin L, Li C, Xingzhu Y, Bangfu W, Ying Z, Yu W, Li M, Chanhua L, Dongyan L, Bichao X, Yanyan L, Ping Y, Chao G, Yuhan T
Food research international (Ottawa, Ont.) 2025 Dec;221(Pt 3):117392
Food research international (Ottawa, Ont.) 2025 Dec;221(Pt 3):117392
Targeting and Suppression of Survivin in Cancer Cells Based on the Interaction of Cell Surface Vimentin with N‑Acetylglucosamine-Bearing Polymers.
Kitagawa K, Kobayashi S, Miura Y, Tanaka M, Ise H
ACS omega 2025 Aug 26;10(33):37162-37175
ACS omega 2025 Aug 26;10(33):37162-37175
USP15 Facilitates Colorectal Cancer Immune Evasion through SMYD3/CCL2-Dependent Myeloid-Derived Suppressor Cell Recruitment.
Han S, Cui L, Wang B, Ruan Y, Shi M, Hong C, Guan X, Chen Z, Li Y, Liao Y, Ma M, Lu X, Wang H, Zhang Y, Liu C
Cancer immunology research 2025 Aug 1;13(8):1226-1245
Cancer immunology research 2025 Aug 1;13(8):1226-1245
DNA methyltransferase DNMT3A inhibits TP53AIP1 expression and promotes cervical cancer development and metastasis.
Pan X, Du X, Jia S
Cytotechnology 2025 Apr;77(2):74
Cytotechnology 2025 Apr;77(2):74
Dasatinib demonstrates efficacy in organoid derived paclitaxel-resistant Trp53/Cdh1-deficient mouse gastric adenocarcinoma with peritoneal metastasis.
Liu W, Li L, Guo L, Li H, Tang Z, Wang X, Huang L, Sun Y
Cell regeneration (London, England) 2025 Apr 29;14(1):16
Cell regeneration (London, England) 2025 Apr 29;14(1):16
Novel mechanism of fluoride induced cardiovascular system injury by regulating p53/miR200c-3p during endothelial dysfunction.
Zhang C, Wang Y, Huang F, Zhang Y, Huang M, Liu H, Liu Y, Wang Q, Liu C, Angwa L, Gao Y, Sun D, Jiang Y
Environmental research 2025 Apr 15;271:121102
Environmental research 2025 Apr 15;271:121102
Mechanism of baicalein in treatment of castration-resistant prostate cancer based on network pharmacology and cell experiments.
Dou B, Cui Y, Zhou Q, Fu J, Zhou Y, Zhang X, Zhang Q, Zhang J
Frontiers in pharmacology 2024;15:1397703
Frontiers in pharmacology 2024;15:1397703
Harmine inhibits pulmonary fibrosis through regulating DNA damage repair-related genes and activation of TP53-Gadd45α pathway.
Gong Y, Wang J, Pan M, Zhao Y, Zhang H, Zhang F, Liu J, Yang J, Hu J
International immunopharmacology 2024 Sep 10;138:112542
International immunopharmacology 2024 Sep 10;138:112542
Trimethylamine-N-oxide aggravated the sympathetic excitation in D-galactose induced aging rats by down-regulating P2Y12 receptor in microglia.
Wang P, Mi Y, Yu H, Teng X, Jin S, Xiao L, Xue H, Tian D, Guo Q, Wu Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116549
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 May;174:116549
Cryptochrome 1 regulates ovarian granulosa cell senescence through NCOA4-mediated ferritinophagy.
Ma J, Chen S, Liu J, Liao Y, Li L, Wang CC, Song S, Feng R, Hu H, Quan S
Free radical biology & medicine 2024 May 1;217:1-14
Free radical biology & medicine 2024 May 1;217:1-14
Novel insights into gut health: Cilostazol strengthens gut integrity by adjusting TLR-2/NF-κB/IL-23 and CD44/AKT/GSK-3β/cyclin-D1 trajectories in methotrexate-induced mucositis model.
Mansour SM, Sabra O, El-Komy F, Ahmed K, El-Abhar H
European journal of pharmacology 2024 Jul 15;975:176669
European journal of pharmacology 2024 Jul 15;975:176669
Lipid-like gemcitabine diester-loaded liposomes for improved chemotherapy of pancreatic cancer.
Wang X, Lu H, Luo F, Wang D, Wang A, Wang X, Feng W, Wang X, Su J, Liu M, Xia G
Journal of controlled release : official journal of the Controlled Release Society 2024 Jan;365:112-131
Journal of controlled release : official journal of the Controlled Release Society 2024 Jan;365:112-131
Shenqu xiaoshi oral solution enhances digestive function and stabilizes the gastrointestinal microbiota of juvenile rats with infantile anorexia.
Zhao M, Xiang T, Dong Z, Liu G, Wang P, Qi X, Hao Q, Han N, Liu Z, Li S, Yin J, Zhai J
Journal of ethnopharmacology 2024 Jan 30;319(Pt 1):117112
Journal of ethnopharmacology 2024 Jan 30;319(Pt 1):117112
RNA-binding protein HNRNPD promotes chondrocyte senescence and osteoarthritis progression through upregulating FOXM1.
Jiang H, Zhang Y, Hu G, Ji P, Ming J, Li Y, Zhou Y
Communications biology 2024 Dec 24;7(1):1695
Communications biology 2024 Dec 24;7(1):1695
Curcumin suppresses colorectal cancer by induction of ferroptosis via regulation of p53 and solute carrier family 7 member 11/glutathione/glutathione peroxidase 4 signaling axis.
Ming T, Lei J, Peng Y, Wang M, Liang Y, Tang S, Tao Q, Wang M, Tang X, He Z, Liu X, Xu H
Phytotherapy research : PTR 2024 Aug;38(8):3954-3972
Phytotherapy research : PTR 2024 Aug;38(8):3954-3972
Polystyrene nanoplastics induce cardiotoxicity by upregulating HIPK2 and activating the P53 and TGF-β1/Smad3 pathways.
Yang JZ, Zhang KK, Hsu C, Miao L, Chen LJ, Liu JL, Li JH, Li XW, Zeng JH, Chen L, Li JH, Xie XL, Wang Q
Journal of hazardous materials 2024 Aug 5;474:134823
Journal of hazardous materials 2024 Aug 5;474:134823
In vitro study of HPV18-positive cervical cancer HeLa cells based on CRISPR/Cas13a system.
Zhang A, Zheng X, Chen S, Duan G
Gene 2024 Aug 30;921:148527
Gene 2024 Aug 30;921:148527
Targeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome.
Wu S, Dai X, Xia Y, Zhao Q, Zhao H, Shi Z, Yin X, Liu X, Zhang A, Yao Z, Zhang H, Li Q, Thorne RF, Zhang S, Sheng W, Hu W, Gu H
Cell reports 2024 Apr 23;43(4):114111
Cell reports 2024 Apr 23;43(4):114111
PM2.5 exposure-induced senescence-associated secretory phenotype in airway smooth muscle cells contributes to airway remodeling.
Cheng PP, Yu F, Chen SJ, Feng X, Jia ZH, Hu SH, Cui XL, Zhou YY, Niu Q, Liang LM, Wang M, Song LJ, He XL, Xiong L, Xiang F, Wang X, Ma WL, Ye H
Environmental pollution (Barking, Essex : 1987) 2024 Apr 15;347:123674
Environmental pollution (Barking, Essex : 1987) 2024 Apr 15;347:123674
The zinc figure protein ZNF575 impairs colorectal cancer growth via promoting p53 transcription.
An N, Peng H, Hou M, Su D, Wang L, Shen X, Zhang M
Oncology research 2023;31(3):307-316
Oncology research 2023;31(3):307-316
Mechanism of the HIF-1α/VEGF/VEGFR-2 pathway in the proliferation and apoptosis of human haemangioma endothelial cells.
Zhang W, Sun L, Gao H, Wang S
International journal of experimental pathology 2023 Oct;104(5):258-268
International journal of experimental pathology 2023 Oct;104(5):258-268
The significance of CDT1 expression in non-cancerous and cancerous liver in cases with hepatocellular carcinoma.
Ogawa M, Moriyama M, Midorikawa Y, Nakamura H, Shibata T, Kuroda K, Nakayama H, Kanemaru K, Miki T, Sugitani M, Takayama T
Journal of clinical biochemistry and nutrition 2023 Nov;73(3):234-248
Journal of clinical biochemistry and nutrition 2023 Nov;73(3):234-248
One Stone, Two Birds: A Peptide-Au(I) Infinite Coordination Supermolecule for the Confederate Physical and Biological Radiosensitization in Cancer Radiation Therapy.
Wang J, Zhao J, Ma F, Gong L, Lu Y, Xiao W, Tang H, Gao C, Chen Y, Ma J, Gao Z, Yan J, Han S
Small (Weinheim an der Bergstrasse, Germany) 2023 Mar;19(11):e2204238
Small (Weinheim an der Bergstrasse, Germany) 2023 Mar;19(11):e2204238
Changes in calpain-2 expression during glioblastoma progression predisposes tumor cells to temozolomide resistance by minimizing DNA damage and p53-dependent apoptosis.
Stillger MN, Chen CY, Lai ZW, Li M, Schäfer A, Pagenstecher A, Nimsky C, Bartsch JW, Schilling O
Cancer cell international 2023 Mar 17;23(1):49
Cancer cell international 2023 Mar 17;23(1):49
UBE2T promotes glioblastoma malignancy through ubiquitination-mediated degradation of RPL6.
Tao X, Wu X, Zhou P, Yu X, Zhao C, Peng X, Zhang K, Shen L, Peng J, Yang L
Cancer science 2023 Feb;114(2):521-532
Cancer science 2023 Feb;114(2):521-532
A p53-TLR3 axis ameliorates pulmonary hypertension by inducing BMPR2 via IRF3.
Bhagwani AR, Ali M, Piper B, Liu M, Hudson J, Kelly N, Bogamuwa S, Yang H, Londino JD, Bednash JS, Farkas D, Mallampalli RK, Nicolls MR, Ryan JJ, Thompson AAR, Chan SY, Gomez D, Goncharova EA, Farkas L
iScience 2023 Feb 17;26(2):105935
iScience 2023 Feb 17;26(2):105935
Hydrogen Sulfide Inhibited Sympathetic Activation in D-Galactose-Induced Aging Rats by Upregulating Klotho and Inhibiting Inflammation in the Paraventricular Nucleus.
Yu H, Yu Q, Mi Y, Wang P, Jin S, Xiao L, Guo Q, Wu Y
Biomedicines 2023 Feb 15;11(2)
Biomedicines 2023 Feb 15;11(2)
Baicalein attenuates bleomycin-induced lung fibroblast senescence and lung fibrosis through restoration of Sirt3 expression.
Ji-Hong Y, Yu M, Ling-Hong Y, Jing-Jing G, Ling-Li X, Lv W, Yong-Mei J
Pharmaceutical biology 2023 Dec;61(1):288-297
Pharmaceutical biology 2023 Dec;61(1):288-297
Dimethyl Bisphenolate Ameliorates Carbon Tetrachloride-Induced Liver Injury by Regulating Oxidative Stress-Related Genes.
Wang R, Shen H, Zhang J, Li X, Guo Y, Zhao Z, Wang P, Xie N, Li Y, Qu G, Xie S
Molecules (Basel, Switzerland) 2023 Dec 7;28(24)
Molecules (Basel, Switzerland) 2023 Dec 7;28(24)
Aquaporin 1 Facilitates Ferroptosis, M1 Polarization, Mitochondrial Dysfunction, and Autophagy Damage on Lipopolysaccharide-Induced Macrophage Through Down-Regulation of P53 Signaling Pathway.
Lv W, Liang L, Liu D, Li C, Jia L, Jin Y
DNA and cell biology 2023 Aug;42(8):456-480
DNA and cell biology 2023 Aug;42(8):456-480
Recombinant human p53 adenovirus injection combined with Bortezomib inhibits proliferation and promotes apoptosis in multiple myeloma.
Wang Q, Shi Q, Chen Y, Wang G, Shen L
Leukemia research 2023 Apr;127:107041
Leukemia research 2023 Apr;127:107041
Peritoneal M2 macrophage-derived extracellular vesicles as natural multitarget nanotherapeutics to attenuate cytokine storms after severe infections.
Wang Y, Liu S, Li L, Li L, Zhou X, Wan M, Lou P, Zhao M, Lv K, Yuan Y, Chen Y, Lu Y, Cheng J, Liu J
Journal of controlled release : official journal of the Controlled Release Society 2022 Sep;349:118-132
Journal of controlled release : official journal of the Controlled Release Society 2022 Sep;349:118-132
Circadian clock gene BMAL1 inhibits the proliferation and tumor-formation ability of nasopharyngeal carcinoma cells and increases the sensitivity of radiotherapy.
Zhao C, Meng X, Li Y, Liu L, He Q, Jiang J, Chen Y, Li X, Li Y, Tang Y, Zhou D, Zhou J, Jin F
Chronobiology international 2022 Oct;39(10):1340-1351
Chronobiology international 2022 Oct;39(10):1340-1351
Ginseng under forest exerts stronger anti-aging effects compared to garden ginseng probably via regulating PI3K/AKT/mTOR pathway, SIRT1/NF-κB pathway and intestinal flora.
Hao M, Ding C, Peng X, Chen H, Dong L, Zhang Y, Chen X, Liu W, Luo Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Oct;105:154365
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Oct;105:154365
The miRNA-34a/Sirt1/p53 pathway in a rat model of lens regeneration.
Bi X, Wang R, Song H, Wang Y, Hao P, Li X
Annals of translational medicine 2022 Jun;10(11):636
Annals of translational medicine 2022 Jun;10(11):636
COVID-19 lung disease shares driver AT2 cytopathic features with Idiopathic pulmonary fibrosis.
Sinha S, Castillo V, Espinoza CR, Tindle C, Fonseca AG, Dan JM, Katkar GD, Das S, Sahoo D, Ghosh P
bioRxiv : the preprint server for biology 2022 Jul 18;
bioRxiv : the preprint server for biology 2022 Jul 18;
Choline-induced SLC5A7 impairs colorectal cancer growth by stabilizing p53 protein.
Yin Y, Jiang Z, Fu J, Li Y, Fang C, Yin X, Chen Y, Chen N, Li J, Ji Y, Su X, Qiu M, Huang W, Zhang B, Deng H, Dai L
Cancer letters 2022 Jan 28;525:55-66
Cancer letters 2022 Jan 28;525:55-66
The Role of RAD6B and PEDF in Retinal Degeneration.
Ye Q, Wang J, Liu X, Liu Z, BaZong L, Ma J, Shen R, Ye W, Zhang W, Wang D
Neuroscience 2022 Jan 1;480:19-31
Neuroscience 2022 Jan 1;480:19-31
MiR-4521 plays a tumor repressive role in growth and metastasis of hepatocarcinoma cells by suppressing phosphorylation of FAK/AKT pathway via targeting FAM129A.
Ayesha M, Majid A, Zhao D, Greenaway FT, Yan N, Liu Q, Liu S, Sun MZ
Journal of advanced research 2022 Feb;36:147-161
Journal of advanced research 2022 Feb;36:147-161
Interfering with mitochondrial dynamics sensitizes glioblastoma multiforme to temozolomide chemotherapy.
Wang N, Huang R, Yang K, He Y, Gao Y, Dong D
Journal of cellular and molecular medicine 2022 Feb;26(3):893-912
Journal of cellular and molecular medicine 2022 Feb;26(3):893-912
Tryptophan-sorbitol based carbon quantum dots for theranostics against hepatocellular carcinoma.
Wang Y, Chen J, Tian J, Wang G, Luo W, Huang Z, Huang Y, Li N, Guo M, Fan X
Journal of nanobiotechnology 2022 Feb 14;20(1):78
Journal of nanobiotechnology 2022 Feb 14;20(1):78
Efficient reprogramming of human fibroblasts using RNA reprogramming with DAPT and iDOT1L under normoxia conditions.
Morita K, Nakamura A, Machida M, Kawasaki T, Nakanishi R, Ichida J, Iwata T, Umezawa A, Akutsu H
Regenerative therapy 2022 Dec;21:389-397
Regenerative therapy 2022 Dec;21:389-397
Critical Role of Cathepsin L/V in Regulating Endothelial Cell Senescence.
Li C, Liu Z, Chen M, Zhang L, Shi R, Zhong H
Biology 2022 Dec 26;12(1)
Biology 2022 Dec 26;12(1)
Aerobic glycolysis and tumor progression of hepatocellular carcinoma are mediated by ubiquitin of P53 K48-linked regulated by TRIM37.
Ge Y, Zhao R, Li B, Xiao B, Zhou L, Zuo S
Experimental cell research 2022 Dec 15;421(2):113377
Experimental cell research 2022 Dec 15;421(2):113377
COVID-19 lung disease shares driver AT2 cytopathic features with Idiopathic pulmonary fibrosis.
Sinha S, Castillo V, Espinoza CR, Tindle C, Fonseca AG, Dan JM, Katkar GD, Das S, Sahoo D, Ghosh P
EBioMedicine 2022 Aug;82:104185
EBioMedicine 2022 Aug;82:104185
Identification of distinct genomic features reveals frequent somatic AHNAK and PTEN mutations predominantly in primary malignant melanoma presenting in the ureter.
Huang Y, Wei L, Huang Y, Wen S, Liu T, Duan X, Wang Y, Zhang H, Fan B, Hu B
Japanese journal of clinical oncology 2022 Aug 5;52(8):930-943
Japanese journal of clinical oncology 2022 Aug 5;52(8):930-943
PIN1 Protects Hair Cells and Auditory HEI-OC1 Cells against Senescence by Inhibiting the PI3K/Akt/mTOR Pathway.
Zhang Y, Lv Z, Liu Y, Cao H, Yang J, Wang B
Oxidative medicine and cellular longevity 2021;2021:9980444
Oxidative medicine and cellular longevity 2021;2021:9980444
Pathologic role of peptidyl-prolyl isomerase Pin1 in pulmonary artery remodeling.
Wu C, Ha Y, Zou Y, Liao X, Zhang S, Zhang X, Li R, Xing J, Jie W, Guo J, Li J, Shen Z
American journal of translational research 2021;13(10):11162-11177
American journal of translational research 2021;13(10):11162-11177
Arsenic sulfide reverses cisplatin resistance in non-small cell lung cancer in vitro and in vivo through targeting PD-L1.
Tian W, Sun Y, Cheng Y, Ma X, Du W, Shi W, Guo Q
Thoracic cancer 2021 Oct;12(19):2551-2563
Thoracic cancer 2021 Oct;12(19):2551-2563
Th17/IL-17 induces endothelial cell senescence via activation of NF-κB/p53/Rb signaling pathway.
Zhang L, Liu M, Liu W, Hu C, Li H, Deng J, Cao Q, Wang Y, Hu W, Li Q
Laboratory investigation; a journal of technical methods and pathology 2021 Nov;101(11):1418-1426
Laboratory investigation; a journal of technical methods and pathology 2021 Nov;101(11):1418-1426
Extracellular vesicles derived from hypoxia-preconditioned olfactory mucosa mesenchymal stem cells enhance angiogenesis via miR-612.
Ge L, Xun C, Li W, Jin S, Liu Z, Zhuo Y, Duan D, Hu Z, Chen P, Lu M
Journal of nanobiotechnology 2021 Nov 21;19(1):380
Journal of nanobiotechnology 2021 Nov 21;19(1):380
The intracellular domain of UNC5B facilities proliferation and metastasis of bladder cancer cells.
Huang Y, Zhang Z, Miao M, Kong C
Journal of cellular and molecular medicine 2021 Feb;25(4):2121-2135
Journal of cellular and molecular medicine 2021 Feb;25(4):2121-2135
P53 Activated by ER Stress Aggravates Caerulein-Induced Acute Pancreatitis Progression by Inducing Acinar Cell Apoptosis.
Zhou L, Tan JH, Zhou WY, Xu J, Ren SJ, Lin ZY, Chen XM, Zhang GW
Digestive diseases and sciences 2020 Nov;65(11):3211-3222
Digestive diseases and sciences 2020 Nov;65(11):3211-3222
UNC5B mediates G2/M phase arrest of bladder cancer cells by binding to CDC14A and P53.
Huang Y, Zhu Y, Zhang Z, Li Z, Kong C
Cancer gene therapy 2020 Dec;27(12):934-947
Cancer gene therapy 2020 Dec;27(12):934-947
LINC00460-miR-149-5p/miR-150-5p-Mutant p53 Feedback Loop Promotes Oxaliplatin Resistance in Colorectal Cancer.
Meng X, Sun W, Yu J, Zhou Y, Gu Y, Han J, Zhou L, Jiang X, Wang C
Molecular therapy. Nucleic acids 2020 Dec 4;22:1004-1015
Molecular therapy. Nucleic acids 2020 Dec 4;22:1004-1015
A pilot study comparing the genetic molecular biology of gestational and non-gestational choriocarcinoma.
Lazare C, Zhi W, Dai J, Cao C, Sookha RR, Wang L, Meng Y, Gao P, Wu P, Wei J, Hu J, Wu P
American journal of translational research 2019;11(11):7049-7062
American journal of translational research 2019;11(11):7049-7062
p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors.
Carugo A, Minelli R, Sapio L, Soeung M, Carbone F, Robinson FS, Tepper J, Chen Z, Lovisa S, Svelto M, Amin S, Srinivasan S, Del Poggetto E, Loponte S, Puca F, Dey P, Malouf GG, Su X, Li L, Lopez-Terrada D, Rakheja D, Lazar AJ, Netto GJ, Rao P, Sgambato A, Maitra A, Tripathi DN, Walker CL, Karam JA, Heffernan TP, Viale A, Roberts CWM, Msaouel P, Tannir NM, Draetta GF, Genovese G
Cancer cell 2019 Feb 11;35(2):204-220.e9
Cancer cell 2019 Feb 11;35(2):204-220.e9
NKD1 correlates with a poor prognosis and inhibits cell proliferation by inducing p53 expression in hepatocellular carcinoma.
Zhang S, Li J, Wang X
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Oct;37(10):14059-14067
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Oct;37(10):14059-14067
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- A431 cells were subjected to SDS PAGE followed by western blot with 21891-1-AP(TP53 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-TP53 (IP:21891-1-AP, 3ug; Detection:21891-1-AP 1:1000) with A431 cells lysate 1650ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The TP53 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human TP53. This antibody recognizes human,mouse,rat antigen. The TP53 antibody has been validated for the following applications: ELISA, IHC, IP, WB analysis.
